The drug acetylsalicylic acid instructions for use. The harm and benefits of aspirin - what more? Aspirin for blood thinning - how to take. Effect on blood clotting

The tablet contains 0.1, 0.25 or 0.5 grams of the active substance, as well as lemon acid(as monohydrate) and potato starch.

Release form

• tablets 0.1, 0.25 and 0.5 grams;
• tablets are packaged in blisters or blisters No. 10x1, No. 10x2, No. 10x3.

pharmachologic effect

The drug relieves pain, fever and inflammation , prevents aggregation.

Pharmacological group: NSAIDs.

Pharmacodynamics and pharmacokinetics

Acetylsalicylic acid - what is it?

Acetylsalicylic acid is the salicylic ester of acetic (ethanoic) acid.

The formula of acetylsalicylic acid is (ASA) - C₉H₈O₄.

OKPD code 24.42.13.142 ( acetylsalicylic acid mixed with other drugs).

Getting an ACK

In the production of ASA, the method of esterification with ethanoic acid is used.

Pharmacodynamics

The analgesic effect is due to both central and peripheral action. In febrile conditions, it reduces the temperature by acting on the center of thermoregulation.

Aggregation and platelet adhesiveness , as well as thrombosis decrease due to the ability of ASA to suppress the synthesis of thromboxane A2 (TXA 2) in platelets. Inhibits synthesis prothrombin (coagulation factor II) in the liver and - in a dose exceeding 6 g / day. - increases PTV.

Pharmacokinetics

The absorption of the substance after taking the drug inside is almost complete. The half-life of unchanged ASA is no more than 20 minutes. TCmax ASA in - 10-20 minutes, total salicylate formed due to - from 0.3 to 2.0 hours.

Approximately 80% is in the bound state in plasma. acetylsalicylic and salicylic acids . Biological activity persists even when the substance is in protein-bound form.

Metabolized in the liver. Excreted by the kidneys. The excretion is affected by the pH of the urine: when it is acidified, it decreases, and when it is alkalized, it increases.

Pharmacokinetic parameters depend on the magnitude taken dose. Elimination of a substance is non-linear. Moreover, in children of the 1st year of life, in comparison with adults, it proceeds much more slowly.

Indications for use: what do Acetylsalicylic acid tablets help with?

Indications for the use of Acetylsalicylic acid are:

• febrile conditions in diseases of an infectious and inflammatory nature;
• rheumatoid arthritis ;
• rheumatism ;
• inflammatory lesion myocardium , the cause of which is an immunopathological reaction;
• pain syndrome various origins, including toothache(including headache associated with alcohol withdrawal syndrome), joint and muscle pain, neuralgia, migraine ,algomenorrhea .

Also aspirin (or acetylsalicylic acid) is applied in preventive purposes under threat thrombosis ,thromboembolism , MI (when the drug is prescribed for secondary prevention).

Contraindications

Reception of ASA is contraindicated in:

• "aspirin" asthma ;
• during an exacerbation erosive ulcerative lesions alimentary canal ;
• stomach/intestinal bleeding ;
• avitaminosis K ;
• hemophilia , hypoprothrombinemia , hemorrhagic diathesis ;
• G6PD deficiency;
• portal hypertension ;
• insufficiency of kidney / liver function;
• aortic dissection;
• during treatment (if the weekly dose of the drug exceeds 15/mg);
• gouty arthritis, gout;
• (absolute contraindications are the first three and the last three months);
• hypersensitivity to ASA / salicylates.

Side effects

Side effects of ASA treatment may include:

• nausea;
• gastralgia;
• anorexia;
• thrombocytopenia;
• erosive and ulcerative lesions of the digestive canal;
• and/or liver failure.

At long-term use there is noise in the ears, reduced hearing acuity, impaired vision, dizziness and - when taking high doses - headaches. There may also be bleeding hypocoagulation , vomit, bronchospasm .

Acetylsalicylic acid, instructions for use (Method and dosage)

At active rheumatism adult patients are prescribed from 5 to 8 g of ASA per day. For a child, the dose is calculated depending on the weight. As a rule, it varies from 100 to 125 mg/kg/day. Multiplicity of application - 4-5 rubles / day.

1-2 weeks after the start of the course, the dose for a child is reduced to 60-70 mg / kg / day, for adult patients, the dosage remains the same. Continue treatment should be up to 6 weeks.

According to the instructions for the use of Acetylsalicylic acid, the drug should be discontinued gradually over 1-2 weeks.

Acetylsalicylic acid for headaches and as a remedy for fever is prescribed in lower dosages. Yes, at pain syndrome and feverish conditions dose per 1 dose for an adult - from 0.25 to 1 g with a frequency of applications from 4 to 6 rubles / day.

It should be remembered that ASA is especially effective in headache if the pain is provoked. increased ICP(intracranial pressure).

For kids optimal dose at one time 10-15 mg / kg. Multiplicity of applications - 5 rubles / day.

Treatment should not last more than 2 weeks.

For a warning thrombosis and embolism ASA take 2-3 rubles / day. 0.5 g each. To improve the rheological properties (for liquefaction), the drug is taken for a long time at 0.15-0.25 g / day.

For a child older than five years of age, a single dosage is 0.25 g, four-year-old children are allowed to give 0.2 g of ASA once, two-year-old children - 0.1 g, and one-year-olds - 0.05 g.

It is forbidden to give ASA to children from the temperature that rises against the background viral infection . The drug acts on the same structures of the brain and liver as some viruses, and in combination with viral infection may cause the child to develop Reye's syndrome .

The use of ASA in cosmetology

A face mask with Acetylsalicylic acid allows you to quickly relieve inflammation, reduce tissue swelling, remove redness, remove the surface layer of dead cells and clean clogged pores.

The drug dries the skin well and is perfectly soluble in fats, which makes it advisable to use it as a remedy for acne : tablets, moistened with water, applied to inflamed elements on the face or added to face masks.

Acetylsalicylic acid from acne works well in combination with lemon juice or honey. Effective for skin problems and clay mask.

To prepare a lemon-aspirin mask, tablets (6 pieces) are simply ground with freshly squeezed juice until a homogeneous mass is obtained. The drug is then applied topically to inflamed pimples and leave them to dry.

A mask with honey is prepared as follows: tablets (3 pieces) are moistened with water, and then, when they dissolve, mixed with 0.5-1 teaspoon (tea) of honey.

To prepare a clay mask, mix with warm water 6 crushed ASA tablets and 2 teaspoons (teaspoons) of white/blue clay.

Overdose

An overdose may result in:

• long-term treatment of ASA;
• single injection of too high a dose of the drug.

An indication of an overdose is salicylism syndrome , manifested by general malaise, hyperthermia, tinnitus, nausea, vomiting.

Strong accompanied convulsions , stupor, severe dehydration, non-cardiogenic lung , violations of CBS, shock.

In case of an overdose of ASA, the victim should be immediately hospitalized. They wash his stomach, give him, check the KOS.

Depending on the state of the KOS and the balance of water and electrolytes, the introduction of solutions may be prescribed, sodium citrate and sodium bicarbonate (as an infusion).

If the pH of the urine is 7.5-8.0, and the plasma concentration of salicylates exceeds 300 mg / l (in a child) and 500 mg / l (in an adult), intensive therapy is required alkaline diuretics .

With severe intoxication, they carry out; replenish fluid loss; appoint symptomatic treatment.

Interaction

Enhances toxicity barbituric drugs ,valproic acid , methotrexate , effects of oral hypoglycemic drugs, narcotic , sulfa drugs .

Weakens effects diuretics (potassium-sparing and loop), antihypertensive drugs from the ACE inhibitor group, action uricosuric agents .

When used simultaneously with antithrombotic drugs , thrombolytics ,indirect anticoagulants increases the risk of bleeding.

GCS strengthen toxic effect ASA on the mucosa of the digestive canal, increase its clearance and reduce plasma concentration.

When used simultaneously with Li salts, it increases the plasma concentration of Li + ions.

Enhances the toxic effect of alcohol on the mucosa of the digestive canal.

Terms of sale

Non-prescription drug.

Recipe in Latin (sample):

Rp: Acid acetylsalicylici 0.5
D.t. d. No. 10 in tab.
S. 1 tablet 3 rubles / day after meals with plenty of water.

Storage conditions

Tablets should be stored in a dry place below 25°C.

Best before date

Four years.

special instructions

The drug should be used with caution in people with pathologies of the kidneys and liver , with increased bleeding, decompensated CHF, during treatment with anticoagulants, as well as in people with a history of erosive and ulcerative lesions digestive tract and/or stomach/intestinal bleeding .

Even in small doses, ASA reduces excretion uric acid that in predisposed patients can cause an acute attack gout .

When taking high doses of ASA or the need for long-term treatment with the drug, it is necessary to regularly monitor the level and be observed by a doctor.

As an anti-inflammatory agent, the use of ASA at a dose of 5-8 g / day. limited due to increased risk development adverse reactions from the gastrointestinal tract.

To reduce bleeding during surgery and in postoperative period, taking salicylates is stopped 5-7 days before surgical intervention.

When taking ASA, it should be remembered that this remedy can be taken for no more than 7 days without consulting a doctor for pain relief. As an antipyretic ASA, it is allowed to drink no more than 3 days.

Chemical properties of a substance

Upon crystallization of ASA, colorless needles or monoclinic polyhedrons with a slightly sour taste are formed. The crystals are stable in dry air, however, with increasing humidity, they gradually hydrolyze to salicylic and acetic acids.

Substance in pure form is a crystalline powder white color and virtually odorless. The appearance of an odor acetic acid is evidence that the substance has begun to hydrolyze.

In newborn babies, salicylic acid is able to displace from the connection with albumin bilirubin and contribute to the development encephalopathy .

ASA easily penetrates into all body fluids and tissues, including cerebrospinal, synovial and peritoneal fluid.

In the presence of edema and inflammation, the penetration of salicylate into the articular cavity is accelerated. In the stage of inflammation, on the contrary, it slows down.

Acetylsalicylic acid and alcohol

Alcohol during ASC is contraindicated. This combination can cause stomach and intestinal bleeding, as well as severe reactions hypersensitivity.

Why Acetylsalicylic Acid for a Hangover?

ASA is a very effective remedy for a hangover, due to the antiplatelet effect of the drug.

However, it should be remembered that it is better to take a pill not to drink alcohol, but about 2 hours before the feast. This reduces the risk of developing microthrombi in small vessels brain and - in part - tissue edema.

Use during pregnancy and breastfeeding

Acetylsalicylic acid during pregnancy is contraindicated. Especially in the first and last three months of gestation. On the early dates taking the drug may increase the risk of developing birth defects, in the later stages - prolonged pregnancy and weakening labor activity.

ASA and its metabolites in small quantities pass into milk. After accidental drug ingestion side effects infants were not observed, and therefore interrupt breast-feeding(GV), as a rule, is not necessary.

If a woman is shown long-term treatment high doses of ASA, it is necessary to stop HB.

Acetylsalicylic acid is an agent that has a pronounced anti-inflammatory effect. The medicine eliminates high temperature and pain, reduces platelet aggregation. Learn how to use the drug, in what quantities to use and what helps acetylsalicylic acid - detailed instruction for use contains all necessary information.

pharmachologic effect

The tool prevents the synthesis of prostaglandins, which are involved in inflammatory processes, contribute to the appearance of pain and fever. As a result of a significant decrease in the amount of prostaglandins, the vessels dilate, which contributes to increased sweating. So the drug has an antipyretic effect.

When using the medication, the nerve endings become less sensitive to pain. The medicine is taken orally, the maximum level active substance in the blood is reached in short term- after 10-20 minutes. The level of salicylate, which occurs as a result of the metabolism that has occurred, rises within two hours. The excretion of the components of the drug is carried out by the kidneys. Partial excretion is carried out 20 minutes after taking the drug, salicylate is partially removed from the body after 2 hours.

Release form and composition

Acetylsalicylic acid is available in tablets. Composition presented different amount active substance - 100, 250, 50 mg, supplemented with citric acid and potato starch.

Aspirin and Analgin

Many are interested in whether aspirin is acetylsalicylic acid or not? Is acetylsalicylic acid aspirin or analgin? Aspirin is a derivative of salicylic acid. Acetylsalicylic acid, often referred to as aspirin, was obtained by replacing one hydroxyl group. Therefore, analgin is a completely different drug.

What does acetylsalicylic acid help with?

For decades, aspirin has been the most popular drug in the world.

The medicine is prescribed when:

• fever;
• rheumatoid arthritis;
• rheumatic fever, occurring in an acute form;
• Dressler's syndrome;
• rheumatic chorea;
• a heart attack in which the lungs are affected;
• acute thrombophlebitis;
• headaches, including migraines;
• osteoarthritis;
• neuralgia;
• various pain sensations - with diseases of the teeth, with menstruation, accompanied by discomfort; pain in muscles and joints;
• diseases of the spine, accompanied by syndromes, the list is represented by osteochondrosis, sciatica, lumbago;
• myocardial infarction, ischemic heart disease, atrial fibrillation, thromboembolism (used for prevention).

Contraindications and side effects

Contraindications to the use of the drug are presented by a list that includes:

• portal hypertension;
• bleeding in the digestive tract;
• Reye's syndrome;
• hemorrhagic diathesis;
• aspirin triad;
• insufficient amount of vitamin K in the body and glucose-6-phosphate dehydrogenase;
• the presence of erosive and ulcerative lesions in the gastrointestinal tract in an acute form;
• hemophilia;
• insufficiency of liver and kidney functions;
• the presence of a dissecting aortic aneurysm;
• hypoprothrombinemia;
• periods of pregnancy, lactation;
• excessive sensitivity of the body to the components this tool and other drugs that eliminate inflammatory reactions, which is manifested by the development of rhinitis and the appearance of urticaria.

Possible negative reactions

Some people may develop side effects:

• diarrhea;
• nausea;
• skin rashes;
• the appearance of noise in the ears;
• the occurrence of erosive and ulcerative lesions, bleeding in the digestive tract;
• angioedema;
• development of the aspirin triad;
• the appearance of pain in the abdomen;
• the occurrence of thrombocytopenia, anemia;
• development of anorexia;
• Reye's syndrome;
• bronchospasm;
• the appearance of headaches, dizziness;
• visual impairment;
• hemorrhagic syndrome;
• deterioration in the condition of heart failure occurring in a chronic form;
• disturbances in the functioning of the kidneys and liver.

If the doctor has prescribed acetylsalicylic acid, the instructions for use and contraindications should be carefully studied in order to avoid negative consequences.

The use of large doses of the drug

When using the drug in in large numbers that do not correspond to the recommended doses are possible negative reactions organism. Overdose leads to the following problems:

• violations acid-base balance and electrolyte;
• confusion of consciousness;
• nausea, accompanied by vomiting, the presence of pain in the abdomen;
• dehydration of the body;
• hearing and vision problems;
• tremor;
• sleepy state.

AT rare cases abuse of the drug leads to metabolic acidosis and coma.

How to use

According to the instructions for use of acetylsalicylic acid, the tablets are taken after meals. You can drink the drug not only plain water, but also mineral alkaline, as well as milk.

The dosage is determined by the doctor. If it is not possible to see a doctor and the problem is not significant, you can take aspirin in the amount of 1-2 tablets, which corresponds to 500-1000 mg. The dose indicated is for an adult. 3-4 medications are allowed per day.

Is it possible to use 2 tablets of acetylsalicylic acid 4 times a day? It is forbidden to use the medicine in such an amount. Maximum daily dose corresponds to 6 tablets. You can be treated with the drug for no longer than two weeks.

Effect on blood clotting

Acetylsalicylic acid thins the blood. To learn how to take pills to improve the rheological properties of the blood, you should consult a doctor. The specialist will select an individual dosage. To prevent platelet adhesion, the drug is used in an amount of 0.5 tablets / day. The duration of the course is usually 2-3 months.

myocardial infarction

To prevent myocardial infarction, 250 mg of the drug per day is used. With thromboembolism and disorders cerebral circulation also use 0.5 tab. / day. Gradually, the amount of the drug is increased to 1000 mg (2 tablets / day).

Instructions for use of Acetylsalicylic acid at a temperature in children and adults

Aspirin is usually prescribed for a cold.

Tablets at a temperature are not used on an empty stomach. If you need to bring down the temperature of an adult, the recommended dosage is 250-1000 mg of the drug. You can take the medicine 3 or 4 times a day.

At a temperature, children are given from 100 to 300 mg of the drug. It is advisable that the doctor select the dose of the medication. The size of the dose for children is determined according to age.

1. To kid over two years old give 100 mg of the drug.
2. From the age of three use of 150 mg is allowed.
3. When treating a child over four years old it is necessary to apply 200 mg of the drug, and in the treatment of a child of age over five years old- 250 mg.
4. Acetylsalicylic acid in the recommended amount can be given to a child 3 or 4 times a day.

For headache

Acetylsalicylic acid is an effective remedy for headaches. You can also take paracetamol. The drug is potent, because it can both benefit the body and harm it. When determining the appropriate dose of the drug, you should be as careful as possible. If rest is not planned in the near future, take two tablets. If after taking the drug it will be possible to sleep or relax, the dose of the drug should be reduced to 0.5-1 tablet. To obtain the desired effect, the medication should be taken immediately after the onset of discomfort.

The indicated doses of the drug are intended for use by an adult. For children, this treatment option is not suitable.

Hangover

Regardless of the reasons for the development of a headache, it is possible to effectively solve the problem that has arisen. For example, in everyday life, people often take the drug with a hangover. But we should not forget that the drug eliminates only the pain, but not the hangover itself. To get rid of the problem, use other medicines for a hangover.

How does aspirin affect blood pressure?

Does aspirin raise or lower blood pressure? The drug does not affect the performance in any way blood pressure. The ability of the remedy to eliminate pain for migraine and reduce intracranial pressure due to its ability to thin the blood. It is harmful to use the drug for hypertension due to the risk of bleeding.

Reception during menstruation and toothache

Can I use the product during menstruation? In such cases, you can use the drug, but with caution and prior consultation with a doctor. The recommended dose is 1 tablet 2 times a day, but it is still better to use other painkillers for these purposes - analgin, spasmalgon, no-shpu.

Aspirin also helps with toothache, because it is able to have a pronounced analgesic effect. But you can not use more than 4000 mg of the drug per day. Otherwise, severe brain damage may occur and internal organs. Children under 12 years of age should select other drugs, as well as pregnant women. Paracetamol will also help with the appearance of a toothache.

How to get rid of acne

The drug helps to get rid of acne. It acts quickly and is one of the most effective means. Acetylsalicylic acid, when used on the face, destroys bacteria, which allows you to stop the inflammatory process and dry the skin. For treatment, the tablet must be dissolved in water and the liquid used for wiping. The solution is applied pointwise, directly on the acne.

masks

1. A face mask with honey helps to heal the skin. For 3-4 tablets, honey and water are required in the amount of 1 tsp. and 5 drops respectively. From these components, a slurry is prepared, which is applied for a quarter of an hour. The remains of the product are washed off with warm water.
2. A mask with acetylsalicylic acid for acne may contain other ingredients, such as black clay. The component is prepared in the amount of several tablespoons, diluted with water to obtain a homogeneous mass. Then the last and main ingredient is added - Acetylsalicylic acid in the form of a powder (1 tab. per 1 tbsp. Clay). The prepared slurry covers the skin of the face for 20 minutes, after which it is washed off with cool water.

If you decide to use acetylsalicylic acid to fight acne, do not forget that the courses should be short, otherwise you can dry out the skin. If you have dry skin, be careful when choosing this method acne treatment.

Acetylsalicylic acid is suitable for the face in cases where the skin is oily

Before using masks, make sure that the body's reaction to the effects of the components is normal. Otherwise, there is a risk of irritation. When searching for a remedy with acetylsalicylic acid for acne, reviews will help you make the most correct choice.

Acetylsalicylic acid for hair

Aspirin renders beneficial effect on the hair follicles. A drug:

• restores shine;
• eliminates the consequences of unsuccessful staining;
• brightens uncolored hair in a natural way;
• increases volume;
• accelerates the growth process;
• neutralizes Negative influence chlorine when visiting the pool;
• eliminates electrification and alopecia.

However, not everyone and not always can use aspirin for hair restoration. You can not often do compresses and masks. When used externally, the main component of the product penetrates well through the tissues. Aspirin for hair can be used from the age of 12, because with earlier use there is high risk occurrence of Reye's syndrome. Those who have eczema, psoriasis or dry seborrhea, as well as owners of sensitive skin care based on the use of Acetylsalicylic acid is not suitable.

Easy to use: dissolve 2-3 tablets in warm water and add to any hair masks.

childbearing, lactation

During pregnancy, it is strictly forbidden to use Acetylsalicylic acid. A nursing mother should also not use the medicine. Pregnant women are not prescribed medication because of the content of harmful substances.

Aspirin and alcohol

It is important to know how to take medicine so as not to harm your body.

Are acetylsalicylic acid and alcohol compatible?

With their simultaneous use, the mucous membrane of the digestive tract is irritated, it is possible to provoke the development of allergies, the appearance of ulcers and intragastric bleeding, the occurrence of a stroke, heart attack. Possible death.

It is necessary to take the medicine before drinking alcohol. Using it for a day, it will be possible to reduce the severity of a hangover.

Combination with caffeine

Caffeine can be used with the drug. However, there are contraindications, so you should consult with your doctor.

Best before date

The shelf life of the drug is 2 years. It is necessary to store the product at room temperature in a place where light and moisture do not penetrate, children and animals do not have access.

What is acetylsalicylic acid, what helps and how to take it, is indicated in the instructions for use. It is especially important to consult a doctor when treating children. For young patients, the drug can be very dangerous.

Acetylsalicylic acid is a non-steroidal anti-inflammatory drug that has antipyretic, analgesic and anti-inflammatory effects. Produced in the form of tablets.

Pharmacological action of acetylsalicylic acid

In accordance with the instructions for Acetylsalicylic acid, the active ingredient of the drug is acetylsalicylic acid. Excipients in the composition of the tablets are citric acid and potato starch.

When used, Acetylsalicylic acid has analgesic, analgesic, anti-inflammatory and antipyretic effects on the body.

Acetylsalicylic acid tablets effectively eliminate headaches, feverish conditions, neuralgia, and rheumatism.

The anti-inflammatory property of the drug is due to its influence on the processes that occur directly in the focus of inflammation.

The antipyretic property of Acetylsalicylic acid is associated with the effect of the active substance on the hypothalamic centers of the brain responsible for thermoregulation.

The analgesic property is due to the effect on the centers nervous system which are responsible for pain sensitivity.

The instructions for Acetylsalicylic acid indicate that the drug inhibits the activity of the cyclooxygenase enzyme, which leads to a disruption in the synthesis of prostaglandins. Due to this, there is a dulling of the sensitivity of peripheral nerve endings in relation to various pain mediators, the severity of inflammation decreases, and the effect on the thermoregulation center also decreases.

At oral administration the drug is absorbed from gastrointestinal tract. Absorption stops with the advance of the drug in small intestine and an increase in acidity. Acetylsalicylic acid tablets have high bioavailability. The substance is metabolized in the liver with the formation of several metabolites. The period of complete elimination of the drug from the body depends on the age of the patient and the amount accepted means. In adults, this period is 4-40 hours. When taking Acetylsalicylic acid in children, the elimination time of the drug is reduced. Excreted from the body through the kidneys.

Acetylsalicylic acid freely crosses the blood-brain barrier synovial fluid as well as breast milk.

Indications for the use of Acetylsalicylic acid

Indications for acetylsalicylic acid are:

• Acute rheumatic fever, rheumatic chorea, Dressler's syndrome, rheumatoid arthritis;
• Diseases of the spine, which are accompanied by pain syndromes (lumbago, sciatica, osteochondrosis);
• Migraine, headaches, joint, muscle, menstrual and toothaches, neuralgia, osteoarthritis;
• feverish syndrome;
• Ischemic heart disease, thromboembolism, atrial fibrillation and myocardial infarction (as a prophylactic);
• Acute thrombophlebitis, pulmonary infarction.

Method of application and dosage

Acetylsalicylic acid tablets should be taken orally after meals with enough water or milk.

In accordance with the instructions Acetylsalicylic acid for adults is prescribed 1-2 tablets (500-1000 mg) 3-4 times a day. The daily dose should not exceed 6 tablets. Maximum duration course of therapy - 2 weeks.

For improvement rheological property blood and as an inhibitor of platelet adhesion in myocardial infarction, ½ tablet of the drug is recommended daily. The duration of the use of Acetylsalicylic acid is 2-3 months.

Acetylsalicylic acid for children aged 2-3 years is prescribed at a dosage of 100 mg, children 3-4 years old should take 150 mg, 4-5 years old - 200 mg, over 5 years old, 250 mg of the drug is recommended. The frequency of taking Acetylsalicylic acid by children is 3-4 times a day.

Contraindications for use

Acetylsalicylic acid is not prescribed if the patient has such diseases and conditions as:

• Gastrointestinal bleeding;
• Aspirin triad;
• Exacerbations of erosive and ulcerative lesions of the digestive tract;
• Reactions to the use of acetylsalicylic acid and other anti-inflammatory drugs in the form of urticaria and rhinitis;
• Hemorrhagic diathesis;
• Hemophilia;
• Hypoprothrombinemia;
• portal hypertension;
• Dissecting aortic aneurysm;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Vitamin K deficiency;
• Renal and liver failure;
• Reye's syndrome.

Also, acetylsalicylic acid is contraindicated in pregnant women, during lactation and with hypersensitivity to the components of the drug.

Side effects of acetylsalicylic acid

When using Acetylsalicylic acid, patients may experience such adverse reactions from the body as:

• Nausea;
• Stomach ache;
• Anorexia;
• Diarrhea;
• Bleeding of the gastrointestinal tract;
• Erosive and ulcerative lesions;
• Headaches, dizziness;
• Noise in ears;
• Violations of the functions of the organs of vision;
• Anemia, thrombocytopenia;
• Violations of the liver and kidneys;
• hemorrhagic syndrome;
• Skin rash;
• Bronchospasm;
• Quincke's edema;
• Increased signs of chronic heart failure;
• Reye's syndrome;
• Aspirin triad.

Overdose

When taking Acetylsalicylic acid tablets in quantities significantly higher than recommended, electrolyte and acid-base balance disorders occur.

In accordance with reviews of Acetylsalicylic acid, patients with an overdose experience nausea, abdominal pain, vomiting, visual and hearing impairment, confusion, drowsiness, tremor, dehydration.

In rare cases, during therapy with Acetylsalicylic acid, coma and metabolic acidosis are noted.

Additional Information

Therapy with the drug should be carried out only if there are direct indications for Acetylsalicylic acid and under the supervision of the attending physician.

The instructions for Acetylsalicylic acid indicate that the medicine should be stored in a dark, cool and out of the reach of children.

Shelf life - 48 months.

From pharmacies, Acetylsalicylic acid is dispensed over the counter.

Acetylsalicylic acid, tablets: instructions for use

Compound

pharmachologic effect

Pharmacokinetics

Indications for use

Fever in infectious and inflammatory diseases;

Pain syndrome of low and medium intensity of various origins.

Contraindications

Dosage and administration

Side effect

When assessing the frequency of adverse reactions, the following gradation is used:

Very common: ≥1/10;

Very rarely:

Not known: Frequency cannot be estimated due to lack of data.

From the side digestive system: often - nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely - the occurrence of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, impaired liver function.

From the side of the central nervous system: prolonged use may cause dizziness, headache, reversible visual impairment, tinnitus, aseptic meningitis.

From the hematopoietic system: rarely - thrombocytopenia, anemia.

From the blood coagulation system: rarely - hemorrhagic syndrome, prolongation of bleeding time.

From the urinary system: rarely - impaired renal function; with prolonged use - acute renal failure, nephrotic syndrome. allergic reactions: infrequently - skin rash; rarely - Quincke's edema, bronchospasm, "aspirin triad" (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and pyrazolone drugs).

Others: very rarely - Reye's syndrome; with prolonged use - increased symptoms of chronic heart failure.

Overdose

Overdose is possible with a single administration of excessively high doses of the drug or with prolonged use.

Symptoms: salicylism syndrome (nausea, vomiting, tinnitus, general malaise, fever). More severe poisoning - stupor, convulsions and coma, non-cardiogenic pulmonary edema, severe dehydration, CBS disorders (first - respiratory alkalosis, then metabolic acidosis), renal failure and shock.

Interaction with other drugs

With simultaneous use with acetylsalicylic acid:

Antacids containing magnesium and / or aluminum hydroxide slow down and reduce the absorption of acetylsalicylic acid;

Blockers calcium channels, means that limit the intake of calcium or increase the excretion of calcium from the body - the risk of bleeding increases;

Enhanced action of heparin indirect anticoagulants, methotrexate, phenytoin, valproic acid;

Antidiabetic agents - lowering blood sugar levels;

GCS - increases the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding;

Decreases the effectiveness of diuretics (spirolactone, furosemide);

Other NSAIDs - increased risk of side effects;

Acetylsalicylic acid may reduce plasma concentrations of indomethacin, iroxicam;

The effectiveness of uricosuric agents decreases;

Griseofulvin - possible violation of the absorption of acetylsalicylic acid;

The concentrations of digogsin, barbiturates and lithium salts in blood plasma increase;

Reducing the effectiveness of captopril and enalapril (when using acetylsalicylic acid in high doses);

Caffeine - increases the rate of absorption, plasma concentration and bioavailability of acetylsalicylic acid, the risk of adverse reactions;

Platelet aggregation inhibitors - increased risk bleeding;

Alcohol - increased risk of gastrointestinal ulcers and bleeding;

Serotonin reuptake inhibitors - increases the risk of gastrointestinal bleeding.

Precautionary measures

5-7 days before surgery, it is necessary to cancel the reception (to reduce bleeding during the operation and in the postoperative period). Irritant action on the gastrointestinal tract is reduced when administered after meals. During long-term therapy, it is recommended to regularly perform a blood test and examine the feces for occult blood. Not recommended for the relief of febrile syndrome in children.

ACK even in not large doses ah reduces the excretion of uric acid from the body, which can cause the development acute attack gout in predisposed patients. During the period of treatment should refrain from taking ethanol.

Use during pregnancy and lactation. Contraindicated in I and III trimester pregnancy, during lactation.

Has a teratogenic effect; when used in the first trimester leads to the development of splitting upper sky; in the III trimester causes inhibition of labor activity (inhibition of Pg synthesis), premature closure ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the "small" circle of blood circulation. It is excreted in breast milk, which increases the risk of bleeding in a child due to impaired platelet function. At the time of treatment, breastfeeding should be stopped.

Influence on the ability to drive a car and other potentially dangerous mechanisms. Due to the possibility of developing adverse reactions from the nervous system, it should be taken with caution.

Release form

10 tablets in a blister pack.

10 tablets in a blister pack.

One, two or three blisters or non-cell packs, together with instructions for use, are placed in a pack of box cardboard.

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

Almost everyone in home first aid kit there is acetylsalicylic acid (aspirin) - a drug known to everyone as an assistant with a hangover and colds. Aspirin is included in the list of the most common medicines in the people and belongs to the group of analgesics, has analgesic and antipyretic properties. It is able to reduce body temperature, fight migraines and febrile illnesses, and also resist inflammatory processes occurring in the human body.

The drug is very popular in medicine, as it is universal in its qualities and, in addition to the listed properties, is able to prevent diseases of cardio-vascular system, fight rheumatism and resist diseases of a different nature. In order to find out what other effects aspirin can have on the human body, we will study detailed instructions medicinal product, its properties and instructions for use.

Acetylsalicylic acid. Instructions for use

On the shelves of pharmacies, aspirin can be found in its pure form, as well as in the composition of other medicines. Combined type preparations containing acetylsalicylic acid have special specifics and Available in powder, capsule and other forms. As for pure aspirin, these are usually 250 or 500 mg tablets. For children under the age of twelve, the drug is provided with a lower dosage and is available in the form of 100 mg tablets.

Properties of acetylsalicylic acid

This drug is different a wide range actions: eliminates pain, thins the blood, lowers the temperature, stops inflammatory processes. When it is used, the level of blood density decreases, having blood clots dissolve, which normalizes circulation in large vessels and capillaries. Improved supply of oxygen to the brain quickly and effectively eliminates pain in the head area, reduces internal pressure and reduce tissue inflammation. After ingestion, aspirin begins to act on the body after 5-15 minutes.

Many doctors believe that the use of this drug for a hangover is dangerous, as there is a risk of developing gastritis, cirrhosis, and damage to brain cells.

Dosage and method of application

In order to ensure maximum effectiveness of the drug it is recommended to take acetylsalicylic acid orally one hour after a meal. The maximum single dose of acetylsalicylic acid for a healthy adult is two tablets. In diseases of the gastric mucosa, it is recommended to reduce the dose to half. Children under 12 years of age are prescribed the drug at the rate of 25 mg per kilogram of the child's weight. For people who have had a myocardial infarction, the dose is 1 tablet per day or half a tablet in two divided doses.

It is necessary to take the drug with water or milk. The duration of treatment with acetylsalicylic acid should be no more than 5 days at intervals of 8 hours.

It is forbidden to take the drug at the same time as alcohol. When symptoms are eliminated alcohol syndrome, experts recommend taking the pill six hours after taking the last serving of alcoholic beverages.

For the strongest effectiveness, it is best to take effervescent aspirin hangover. For example, dissolve an Alka-Seltzer tablet in a glass of warm water and drink it on an empty stomach. This method acts on the body faster and does not irritate the gastric mucosa. In its pure form, in this case, aspirin is best combined with Regidron or activated charcoal.

Indications for use

The drug is prescribed to patients:

And also in order to prevent thromboembolism in atrial fibrillation, vasculitis and valvular heart disease and to alleviate the condition in case of poisoning and hangover syndrome.

Side effects and contraindications

When taking acetylsalicylic acid, side effects:

Aspirin is contraindicated in the following cases:

• with increased sensitivity to the drug;
• in case of exacerbated phases of ulcerative lesions and bleeding in the organs of the gastrointestinal tract;
• with "aspirin" asthma, diathesis, portal hypertension, vitamin K deficiency and gouty arthritis;
• with liver and kidney failure;
• in the 1st and 3rd trimester of pregnancy and lactation.

Acetylsalicylic acid for hangover

A hangover in the human body occurs due to excessive consumption of alcohol-containing drinks. The severity of the syndrome is influenced not only by the amount of alcohol consumed, but also by the weight and sex of the person, as well as the quality of alcohol and the body's ability to resist the action of the toxin. From such hangover symptoms how headache and weakness can be eliminated with the help of analgin and other medicines, along with which there is also aspirin.

The action of acetylsalicylic acid after a hangover

It should be noted that alcohol bad influence to all organs of the human body due to its rapid penetration into the blood and, accordingly, its distribution in all systems inherent in human physiology.

Systematic excessive drinking regardless of strength and quality, it can lead to cirrhosis or stroke, since during the connection of ethanol with blood blood cells stick together, which disrupts the movement of oxygen molecules and cellular respiration of tissues, while clots are formed that can block large arteries and small capillaries; and here the consequences are sad - there is a death of many cells, the actions of which are necessary human body. Ethanol is able to briefly influence vasodilation, and after that a strong constriction occurs, which, in an unfavorable combination with thick blood ends with a stroke.

Severe headaches are caused by a spasm of capillaries that occurs in the brain. Severe intoxication is possible with such ensuing consequences as: heaviness in the head, nausea, dehydration and indigestion.

Aspirin is able to quickly and effectively affect the processes associated with the deterioration of health after a hangover and instantly change the situation, since drug has a wide spectrum therapeutic features , among which:

At the same time, aspirin is not able to do the impossible and eliminate toxins from the human body that remain after the breakdown of ethanol, not in its properties. Therefore, in the treatment of a hangover, it is recommended to use combined preparations with the ability to remove alcoholic poisons.

Use of aspirin for a hangover

In order to usefully get rid of a hangover syndrome, it is important to know how much to take acetylsalicylic acid tablets and how not to harm your own health. For this it is necessary to follow the instructions for use and observe the permissible dosage.

Aspirin should be taken with caution, given the state and level of hangover. Before use, dissolve in water, this will avoid dehydration of the body and the drug will act much faster. It is necessary to drink tablets from the established calculation (1000 mg of aspirin per 70 kg of weight) after 6 hours after drinking alcohol-containing drinks.

Many people ask the question: is it possible to use the drug before the use of alcohol in order to avoid severe consequences and not suffer from a hangover.

According to the instructions for the prevention of hangover syndrome it is recommended to take two tablets of the drug for 24 hours in two divided doses (1 tablet every 12 hours), it is allowed to take the drug earlier, but no later than 2 hours before drinking alcohol. Experts do not recommend drinking tablets with drinks incompatible with the drug: juices, carbonated drinks, coffee and tea.

You can drink acetylsalicylic acid with a hangover syndrome or its prevention in any form. Most the best option considered to be effervescent tablets Aspirin Upsa or Upsarin.

To avoid intoxication of the body after a feast, it is recommended to combine the drug with a temporary protein diet, this gives more likely the fact that the state of the body will please the consequences, because the liver is cleansed and, thus, a significant part of the load is removed from it. It is necessary to exclude from the diet: sausage, meat, mushrooms, beans and peas. They can be replaced fermented milk products, salads, various cereals or sauces, vegetables and fruits.

Contraindications to the use of aspirin for a hangover

There are cases when taking aspirin with a hangover syndrome does not help, but becomes dangerous for a person. Particular care in the use of the drug is required from people suffering from diseases of the stomach, intestines, liver and kidneys. Do not take aspirin and pregnant women, as well as asthmatics and children.

The drug will harm if you combine it with glucocorticosteroids; in case of existing diseases of the gastrointestinal tract, acetylsalicylic acid will cause bleeding in the stomach, and chemical reaction, provoked by the ingestion of aspirin in alcohol, will corrode the walls of the stomach.

The threat to the stomach occurs with an alcohol concentration of 20% or more, and aspirin in this case will only increase negative impact. Most dangerous consequences during the combination of alcohol and this drug, they refer to people with the first and second blood groups.

It is necessary to refrain from taking the drug for people who suffer from stomach ulcers.. Escalating it chronic disease will lead to the opening internal bleeding, there will be a severe form of anemia, which will subsequently serve as an iron deficiency in the body; the level of blood thinning will increase, which will cause heavy and prolonged bleeding.

It is also worth considering that overdose acetylsalicylic acid, in addition to the possibility of provoking a stroke and cirrhosis, can cause a heart attack, so it is important to understand the properties and effects of the drug on the human body and drink pills strictly according to the instructions, and for people who are contraindicated in the drug, completely refuse it.

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