What helps Ciprofloxacin: instructions for use. Ciprofloxacin - instructions for use, active ingredient, contraindications and reviews

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• 500 mg No. 10 - 79 r;
• 250 mg No. 10 - 49 p.

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Instructions for use

Antibiotic from the group of fluoroquinolones of the 2nd generation. Effective against Gram-negative, Gram-positive aerobic bacteria.

The drug is low toxic, well tolerated, but can only be used as prescribed by the attending physician and only after the final diagnosis and type determination. pathogenic microflora.

Indications

Own wide application Ciprofloxacin found in the treatment the following diseases:

1. Diseases respiratory system occurring in acute or chronic form: bronchitis, pneumonia, pleurisy.
2. Otolaryngological diseases (ENT organs): otitis media, sinusitis, sinusitis, tonsillitis.
3. Diseases of the pelvic organs: cystitis, pyelonephritis, adnexitis, oophoritis, prostatitis.

In addition to the main areas of application, Ciprofloxacin is used for diarrhea infectious origin, dysentery and salmonellosis.

In the surgical practice of doctors this drug applied in postoperative period to reduce risks surgical complications.

Due to the bactericidal effect of the drug, it is often used to stop soft tissue infections, as well as in diseases of the musculoskeletal system. locomotive system, peritonitis and other conditions caused by pathogenic bacteria.

Dosage and administration

In practice, the dose of Ciprofloxacin is determined individually for each patient and directly depends on the severity. clinical signs, types of infection, resistance of the virus, as well as the age of the patient, the characteristics of his body. The instructions for the drug contain only standard doses of the drug.

1. For organ diseases genitourinary system appoint 500 mg of the drug twice a day.
2. Diseases of the upper respiratory tract and pathologies of ENT organs require 500 - 750 mg of the drug 2 times a day.
3. With gonorrhea, take 250 - 500 mg once;
4. With Pseudomonas aeruginosa 500 mg 2 times a day.

The treatment course is from 5 to 14 days.

With caution take the drug of a person in whose anamnesis there are severe pathologies liver, kidneys. In such cases, the dose is reduced by half and is determined by the doctor individually for each patient.

Before meals or after?

Tablets should be taken on an empty stomach, before meals, with a small amount of water.

Contraindications

Stop taking ciprofloxacin if you following states and diseases:

• hypersensitivity to the composition of the drug;
• pregnancy;
• breast-feeding;
• childhood up to 18 years;
• lactose intolerance;
• epilepsy.

Pregnancy and lactation

Ciprofloxacin is contraindicated in pregnancy and lactation.

If there is a need to take the drug during breastfeeding, then for the period of treatment of the child you need to transfer to artificial feeding.

Alcohol compatibility

There are no data on the direct interaction of ciprofloxacin with ethanol. But we must remember that drinking alcohol aggravates any infection and creates additional load on the liver.

Overdose

There is no specific antidote for overdose, therefore, if the condition worsens, the patient is shown a general detoxification treatment in a hospital.

Side effects

In some cases, after taking the antibiotic Ciprofloxacin, there may be adverse reactions body:

• nausea, diarrhea;
• vomiting, abdominal pain;
• loss of appetite;
• dizziness, headache;
• violation heart rate.

The appearance of such symptoms is a reason to consult a doctor who can adjust the dose of the drug or prescribe another medicine with similar action, but with a different composition.

Compound

Ciprofloxacin is available in the form of tablets for oral administration of 250 or 500 mg. The active ingredient of the drug is ciprofloxacin hydrochloride, the drug also contains excipients: hypromellose, silicon dioxide, croscarmellose sodium, magnesium stearate, macrogol, white opadry, povidone, titanium dioxide, microcrystalline cellulose.

Produced in a carton box of 10 tablets.

Pharmacology and pharmacokinetics

Ciprofloxacin is an antibiotic with a pronounced antimicrobial effect from the group of fluoroquinolones.

The active component of the drug has the ability to inhibit the enzyme DNA gyrase of bacteria, which allows disrupting DNA replication, as well as cellular proteins of bacteria.

The drug has the ability to affect reproduction pathogenic bacteria.

oral intake drug allows active ingredient drugs penetrate deep into tissues. A high concentration of the active substance is observed in the tissues of the lungs, also the liver, gallbladder, tonsils and other organs where infectious agents may be present.

The maximum concentration of ciprofloxacin hydrochloride in the blood is observed after 30-90 minutes. Tissue concentration internal organs much higher than in plasma.

Storage conditions

Store Ciprofloxacin tablets at a temperature not exceeding 20 degrees. The expiration date of the drug is indicated on the packaging and blister, next to the drug series.

Latin name: Ciprofloxacinum
ATX code: G01AX13
Active substance:
hydrochloride
Manufacturer: Rompharm, Romania/
Balkanpharma, Bulgaria, etc.
Pharmacy leave condition: On prescription
Price: from 15 to 60 rubles.

"Ciprofloxacin" - an antibiotic a wide range actions. The drug has bactericidal properties. It acts on bacteria by disrupting DNA replication and the synthesis of bacterial cell proteins.

Indications for use

As systemic treatment"Ciprofloxacin" is used orally or intravenously in the following cases:

Against venereal infections:

• soft chancre
• Chlamydia
• Gonorrhea

For skin diseases:

• Abscess
• Wounds
• Phlegmon
• burns
• ulcers

Against lung infections:

• Bronchitis
• bronchoectatic
• cystic fibrosis
• pneumonia

Against a group of organ diseases abdominal cavity:

• shigellosis
• campylobacteriosis
• salmonellosis
• Intra-abdominal abscesses
• Infections of the stomach and intestines
• Cholera, typhoid
• yersiniosis
• peritonitis
• Diseases of the gallbladder and ducts

For joint diseases:

• Septic arthritis
• Osteomyelitis

Against diseases of the pelvic organs:

• tubular abscess
• Oophoritis
• Cystitis and pyelonephritis
• Adnexitis
• Pelvioperitonitis
• endometritis
• Salpingitis
• Prostatitis

Against infections of the upper respiratory tract:

• Tonsillitis
• sinusitis
• Sinusitis and pharyngitis
• mastoiditis
• Angina
• Frontita
• Otitis media.

Also "Ciprofloxacin" is used against eye and ear infections and as postoperative therapy.

Compound

One tablet consists of 250 or 500 mg of the main active agent and additional components that make up the antibiotic: titanium dioxide (E 171), silicon dioxide, croscarmellose sodium, hypromellose, potato and corn starch, polysorbate 80, polyethylene glycol 6000, magnesium stearate, hypromellose and microcrystalline cellulose.

The dropper solution includes 200 mg of ciprofloxacin.

Medicinal properties

The drug has a pronounced antimicrobial action(even better than norfloxacin). "Ciprofloxacin" is absorbed in the intestine for a short time especially if taken on an empty stomach. The highest concentration of the drug in the blood is reached one or two hours after ingestion or 30 minutes after injection.

The half-life of the antibiotic is approximately four hours. The drug easily penetrates into all cells and tissues of the body, including the brain. During the day, 40% of the antibiotic is excreted in the urine almost unchanged.

The average price is from 20 to 45 rubles.

Eye and ear drops "Ciprofloxacin"

The solution of drops has a concentration of 0.3%, is bottled in 10 ml or 5 ml in convenient dropper bottles.

The ophthalmic solution has a yellow or yellowish-green tint.

Mode of application

Eye solutions are instilled into the conjunctival sac of the diseased eye, one or two drops with an interval of four hours. If the disease is very difficult, you need to drip two drops into the eye with an interval of an hour. The dosage is reduced after the symptoms become less pronounced.

"Ciprofloxacin", ear drops are instilled 5 drops three times a day. Antibiotic treatment should be continued for another two days after the patient's condition returns to normal.

The average price is from 20 to 40 rubles.

Solution for infusions "Ciprofloxacin"

Solutions for intravenous injections, 1 ml of which contains 2 mg of ciprofloxacin hydrochloride. Poured into jars of 100 ml.

Mode of application

If a sore throat or other illness is severe or the patient is unable to take the medicine orally, it is used intravenously. Why is the infusion agent used at 200 mg for half an hour (if the infection is severe, then 400 mg per hour) twice a day.

The average price is from 15 to 60 rubles.

Tablets "Ciprofloxacin"

Tablets, acting prolonged (for a long time), enclosed in a film shell. Each of them contains 500 or 1000 mg of the substance ciprofloxacin. They are packaged in packs of five or seven.

And tablets containing 250 or 500 mg of the main agent are packed in packs of 10 pieces. Tablets "Ciprofloxacin" are white, coated, convex on both sides.

Mode of application

Tablets are swallowed while drinking right amount water, 250 mg (if a sore throat or other infection is severe, then 500-750 mg) twice or thrice a day.

Long-acting tablets are taken once a day. If the patient has an infection Bladder and ureters, a dose of 250 mg twice a day is required. In the acute form of gonorrheal urethritis, 500 mg is taken as a single dose.

For treatment acute form gonorrhea and cystitis, which do not have complications, the course of antibiotic is one day. With angina and infections of the bladder, ureter, kidneys and abdominal organs, the course lasts a week. Patients with low immune protection organisms should take "Ciprofloxacin" as much as necessary to end the neutropenic phase. It is necessary to take an antibiotic no longer than two months for osteomyelitis, and one to two weeks for tonsillitis and in other cases. If the patient has chlamydia or streptococcal infection, he is prescribed a course lasting ten days.

In the presence of severe kidney damage medicinal dose are reduced by half, and for the elderly - by 30%. It is advisable to continue taking the drug for at least three more days after the body temperature returns to normal and other symptoms disappear.

Contraindications

"Ciprofloxacin" is used for adults, is contraindicated in the presence of intolerance to its components, during pregnancy and breastfeeding, with a lack of glucose-phosphate dehydrogenase, children and adolescents under eighteen years of age. Do not use intravenous infusion for the entire period active growth organism.

Eye drops are forbidden to be instilled in children under one year old and with viral keratitis.

During pregnancy and breastfeeding

Since the drug freely crosses the placenta and into breast milk, it is prohibited to use it during pregnancy and lactation.

Precautionary measures

The medicine should be used with caution in the following diseases:

• Epilepsy
• Atherosclerosis of cerebral vessels
• Severe liver and kidney damage
• Mental illnesses
• During pregnancy and lactation.

It is unacceptable to use ciprofloxacin and alcohol at the same time, since the antibiotic will increase the effect of alcohol and increase the toxic effect on the liver. In addition, it will increase the likelihood of side effects.

Interaction with other drugs

"Ciprofloxacin" is absorbed worse in the intestine and, accordingly, its effectiveness decreases when it is used simultaneously with:

• Antacids
• Didanosine
• Preparations containing iron, aluminum, magnesium and zinc ions.

As a result, they should be taken with Ciprofloxacin at intervals of four hours. Also, the simultaneous use of the drug lengthens the elimination period and, therefore, enhances the toxic effect of the following drugs:

• Cyclosporine
• Theophylline.

Side effects

Swallowing tablets and giving intravenous infusion may interfere with normal functioning various systems organism.

Musculoskeletal: Myalgia, tendovaginitis, or arthralgia may occur

Circulatory: the occurrence of thrombocytosis, anemia, tachycardia, arrhythmia, cardiovascular collapse, as well as a decrease in blood pressure

Gastrointestinal: possible nausea, vomiting, diarrhea, constipation, dry mouth, abdominal pain, hepatitis

Genitourinary: vaginitis, hemorrhagic cystitis acidosis, frequent or difficult urination

Respiratory: bronchospasm, dyspnea, pulmonary embolism

Allergies are sometimes manifested: urticaria, swelling of the lips, neck, face, arms and legs, skin rashes, itching, anaphylactic shock.

Possible consequences of using eye drops and ear solutions: infiltration of the cornea of ​​​​the eyes, blurred vision, unpleasant taste sensations, swelling of the eyelids, lacrimation, itching, burning in the eyes.

Overdose

The consequences of an overdose of "Ciprofloxacin" are similar to the manifestations side effects: pain in the head, fatigue, dizziness, convulsions, confusion. specific symptom is intoxication of the renal parenchyma. Taking the drug in an amount of 16 g causes severe kidney damage. Therefore, in addition to gastric lavage, antacids containing magnesium and calcium are prescribed, which reduces the absorption of the antibiotic in the body.

Terms and conditions of storage

"Ciprofloxacin" is stored in a dark place with low humidity, inaccessible to children, at an air temperature not exceeding 25 ° C. The eye solution is valid for two years from the date of manufacture. Tablets and solution for intravenous infusion- within three years.

Analogues

Ranbaxy Laboratories Limited, India
Price from 44 to 360 rubles.

As part of one tablet of "Cifran" (250 mg), there are 297.07 mg of the main substance - ciprofloxacin hydrochloride. "Cifran" is available: in tablets (250 or 500 mg) and as a solution for intravenous administration. "Cifran" is issued upon presentation of a prescription.

pros

• Effective against infectious and inflammatory diseases
• "Cifran" is approved for use in children over five years of age suffering from cystic fibrosis of the lungs and anthrax

Minuses

• Bumpy tasting and large tablets
• Possible consequences of the use of "Cifran" in the form of nausea, vomiting and diarrhea, etc.

North Star, Russia/Natur Product Europe, Netherlands, etc.
Price from 84 to 500 rubles.

Main active agent- amoxicillin, amoxicillin trihydrate. "Amoxicillin" is sold in the form of tablets, granules for making syrup, solutions for injections that are done intramuscularly.

pros

• It has an antibacterial effect, is used against tonsillitis, bronchitis and other infections.
• Acid resistant

Minuses

• Must be taken every 8 hours - inconvenient
• Negatively affects the gastrointestinal tract.

Krka, Slovenia
Price from 144 to 307 rubles.

The main active agent of "Nolicin" is norfloxacin (500 mg). "Nolicin" is available in tablets of 10 pcs. packaged. Packed 2 packs in a pack.

pros

• "Nolicin" is effective against infections and inflammation of the genitourinary system
• 80% of the drug is excreted from the body by the kidneys unchanged

Minuses

• Tablets are large - difficult to swallow
• "Nolicin" is not recommended during pregnancy and lactation.

Nycomed, Denmark, etc.
Price from 13 to 129 rubles.

Each tablet contains 500 mg of metronidazole. Metronidazole is available in various forms(tablets, cream, etc.).

pros

• Helps kill tumors during radiation therapy
• Used for adults, in the treatment bacterial infections and alcoholism

Minuses

• "Metronidazole" is contraindicated in pregnancy, disorders of the central motor system epilepsy, liver failure
• Tablets have a bitter taste
• Candles leak onto underwear.

Many infectious diseases cannot be cured without the use of antibacterial drugs. In this case, it is necessary to find out what pathogens caused the disease. Only after a series of tests can a specialist make the right appointment. A number of diseases today are treated with the help of medicines from the group of fluoroquinolines. The antibiotic "Ciprofloxacin" is popular among specialists. Instructions for use describes the cases in which the drug can be used.

pharmachologic effect

In medicine, the drug "Ciprofloxacin" is widely used today. Is it an antibiotic or not, and we will find out further. The drug, which is available in the form of tablets, as well as a solution for injection, belongs to the group of a wide spectrum of action. The main active ingredient inhibits protein synthesis of pathogens. As a result, bacteria stop multiplying. They soon die. In many cases, the drug "Ciprofloxacin" can be used. A group of antibiotics from this series has a high activity against almost all gram-positive bacteria, as well as microorganisms that produce beta-lactamase.

Tablets are rapidly absorbed from gastrointestinal tract. When applied antibacterial drug inside its bioavailability is 75%. Medication intake may be affected by food intake. Therefore, experts recommend using the tablets on an empty stomach or an hour after a meal. The main active ingredient is distributed in body fluids and tissues. highest concentration ciprofloxacin is observed in bile. The drug is excreted in the urine.

Indications

When can Ciprofloxacin be used? Is it an antibiotic or not? All these questions will be answered by a specialist. Doctors confidently claim that the drug belongs to the group of antibacterial. Therefore, it can be used for various infectious diseases caused by sensitive to the main active component microorganisms. An antibacterial agent is prescribed as the main element complex therapy ailments of the respiratory tract, pelvic organs, bones, joints, skin, ENT organs. In addition, in patients with reduced immunity, tablets can be used for prophylaxis.

For local application broad-spectrum antibiotics are also suitable. "Ciprofloxacin" is used for infectious conjunctivitis, blepharitis, corneal ulcers, as prophylactic the medicine is used after operations on the eyes or after a foreign body has entered them.

A medication cannot be prescribed during pregnancy and lactation. Experts say that an antibacterial agent can cause serious harm an unborn child. The use of Ciprofloxacin tablets is recommended after reaching the age of 15.

AT rare cases Patients may experience hypersensitivity to the elements of the drug. If any allergic reactions occur, the patient should consult a doctor. It may be necessary to cancel the antibacterial agent or adjust the daily dosage.

For patients over 65 years of age, the medication is prescribed with caution. Under supervision, an antibiotic is taken by people who have impaired kidney function. Tablets are contraindicated in renal failure.

special instructions

Strictly under the supervision of a physician, it is necessary to take Ciprofloxacin tablets for people with diseases such as cerebral atherosclerosis, epilepsy, impaired cerebral circulation, convulsive syndrome obscure origin. During therapy, patients should use a large number of liquids. Thus, it will be possible to avoid the development of many side effects associated with the high toxicity of the antibacterial agent.

Almost all antibiotics affect the functioning of the gastrointestinal tract. This is due to the fact that medicines affect not only pathogens, but also those that support normal microflora. As a result, patients may experience symptoms such as indigestion, diarrhea. The specialist is obliged to prescribe drugs that restore normal work intestines. If the diarrhea does not stop, the prescribed antibiotics are canceled to avoid. Each specialist can say whether the drug "Ciprofloxacin" is an antibiotic or not. Therefore, a qualified doctor will not use the drug as monotherapy. Medicines based on bifidobacteria help to protect the patient from many side effects.

During the treatment of infectious diseases with Ciprofloxacin, it is necessary to control the concentration of urea, creatinine, and hepatic transaminases in the patient's blood. Increased content these substances may indicate the development of hepatotoxicity. In addition, the doctor monitors the patient's heart rate, and also periodically measures arterial pressure. Therapy in most cases is carried out in a hospital setting.

Dosage

Strictly on the recommendation of a doctor, you should take Ciprofloxacin tablets. A group of antibiotics can only be used as directed. qualified specialist. The daily rate is determined individually in accordance with the form of the patient's disease, as well as the characteristics of his body. The minimum dosage for patients over 15 years of age when administered orally may be 250 mg, the maximum - 750 mg. All daily rate is divided into two steps. The interval between the use of tablets should not exceed 12 hours. The course of treatment can be long (up to 4 weeks).

The drug can also be administered intravenously. A single dose in this case is 200-400 mg (also divided into two doses). Usually a two-week course is enough to completely overcome the disease. The decision to continue is made by the doctor based on overall picture disease dynamics. Intravenously, the drug is administered using a dropper for 30 minutes. With jet administration, the bioavailability of the antibacterial agent is significantly reduced.

Local treatment may be prescribed for various infections eye. The patient is injected with 1-2 drops of the solution into each conjunctival sac 5-7 times a day. As soon as the doctor notices the positive dynamics of the disease, the interval between drug injections increases. Maximum daily dosage for adult patients should not exceed 1.5 g.

Overdose

It is worth using the antibiotic "Ciprofloxacin" with caution. Instructions for use states that the reception medicinal product in an increased dosage can lead to the development of side effects. First of all, the patient may feel the symptoms of poisoning. Signs of an overdose are dizziness and nausea. This condition is treated in a hospital setting. The patient's stomach is washed and his well-being is observed. If necessary, symptomatic therapy is carried out.

A large amount of liquid helps to remove toxins from the body in case of an overdose. The patient should take a lot mineral water or unsweetened tea. A small amount of ciprofloxacin can be eliminated by peritoneal dialysis.

Side effects

Do not take the drug "Ciprofloxacin" without consulting a doctor. An antibiotic of which series is suitable in a particular case can only be determined by a specialist after a series of tests. Misuse antibacterial agents may lead to the development of side effects. Most often they appear on the side digestive system. Patients may complain of stomach pain, nausea, or diarrhea. Less common are symptoms such as pseudomembranous colitis, flatulence, cholestatic jaundice. Some patients refuse to eat at all. As a result, anorexia may develop.

From the side of the central nervous system such side effects like dizziness, migraine, increased pressure, feelings of anxiety and fear. In some cases, patients develop depression. In severe psychotic reactions such as nightmares, confusion and hallucinations, the antibacterial agent should be discontinued. Mental disorders can progress. As a result, the patient may unknowingly harm himself.

Side effects sometimes develop from the sense organs. This is a violation of smell and taste, tinnitus, a significant hearing loss. All these symptoms are reversible and completely disappear after discontinuation of the drug.

From the side of cardio-vascular system phenomena such as heart rhythm disturbances, hot flashes, arterial hypotension. On the part of the hematopoietic system, symptoms such as hemolytic anemia, granulocytopenia, thrombocytosis. Most often such side effects develop with intravenous administration drug "Ciprofloxacin". It is difficult to answer which group of antibiotics does not lead to the appearance of such symptoms. It all depends on individual features the patient's body.

drug interaction

The way the drug "Ciprofloxacin" reacts with other medicines proves once again that it belongs to the group of antibacterial agents. It is not recommended to use tablets together with didanosine. "Ciprofloxacin" forms complexes together with aluminum and magnesium salts, which are contained in didanosine. As a result, the bioavailability of the antibiotic is significantly reduced.

It is not recommended to use (NVPS) together with the drug "Ciprofloxacin". Whether it's an antibiotic or not, every specialist knows. Qualified doctors are confident that NSAIDs can provoke the development of seizures in patients who are undergoing antibiotic therapy. The only exception is acetylsalicylic acid. This substance does not harm the patient.

Medicines that contain zinc, iron, magnesium and aluminum ions significantly reduce the bioavailability of the drug. Therefore, the interval between taking medications should not be less than 4 hours. The antibiotic for prostatitis "Ciprofloxacin" is used only in extreme cases. This is due to the need to take medications based on iron and zinc ions.

Analogues

Is "Ciprofloxacin" an antibiotic? This question is asked by many patients who are faced with a particular infectious disease. Doctors unequivocally state that this drug belongs to the group of antibacterial agents. But you can use it only after setting accurate diagnosis. There are many other drugs based on ciprofloxacin in pharmacies. Popular with specialists, for example, are tablets "Tsiprobay". As excipients, they use corn starch, silicon dioxide, magnesium stearate, macrogol, titanium dioxide, and hypromellose. Tablets can be used for various infections of the eyes, kidneys, genitals, respiratory tract and skin. The specialist will make an appointment only when he specifies which microorganisms caused the infection.

Tablets "Tsiprobay" can be prescribed to children older than 5 years. Pregnant and lactating women are not prescribed an antibacterial agent. This is due to the possibility of violation of the integrity cartilage tissue fetus under the influence of ciprofloxacin.

The drug "Ciprofloxacin-Teva" is also common. Antibiotic or not this medicine? If you cannot do without antimicrobial therapy, the medicine "Ciprofloxacin-Teva" can have effective help. It can be confidently asserted that it belongs to the group of antibacterial agents. Tablets quickly cope with infections of the upper respiratory tract, skin, and pelvic organs. As a prophylaxis, the drug is used before operations in ophthalmology. The drug is contraindicated in women during pregnancy and lactation, as well as in patients under 15 years of age.

| Ciprofloxacin

Analogues (generics, synonyms)

Quintor, Cipro, Tsiprobay, Arfloks, Tsiploks, Tsiprinol, Tsiprobid, Tsiproran, Tsiproksin, Tsiprov, Tsiprolak, Tsiprolet, Tsipromide, Tsipropan, Tsiprosan, Afenoxim, Medotsiprin, Tsifobak, Tsiprotsinal, Tsiteral, Tsifran

Recipe

Rp: Ciprofloxacini 0.25
D.t.d: N 20 in tab.
S: 2 tablets 2 times a day.

pharmachologic effect

According to the antibacterial spectrum of action, ciprofloxacin is basically similar to other fluoroquinolones, but it has a relatively high activity; about 3-8 times more active than norfloxacin. The drug is effective when administered orally and parenterally (bypassing the digestive tract).

When taken orally, especially on an empty stomach, it is well absorbed.

Peak plasma concentration is observed 1-2 hours after ingestion and 30 minutes after intravenous administration. The half-life (the time during which 1/2 dose of the administered drug is excreted from the body) is about 4 hours. Little is bound by plasma proteins. It penetrates well into organs and tissues, passes through the blood-brain barrier (the barrier between blood and brain tissue). About 40% is excreted in the urine unchanged within 24 hours.

Mode of application

Ciprofloxacin given to adults by mouth for uncomplicated infections urinary tract 0.125-0.5 g 2 times a day, with complicated urinary tract infections and respiratory tract infections - 0.25-0.5 g 2 times a day; in more severe cases- up to 0.75 g 2 times a day (if not carried out parenteral treatment). The course of treatment is usually 5-15 days.

In case of especially severe infectious diseases and the impossibility of taking tablets orally, they begin with intravenous administration of the drug, preferably in the form of a short-term infusion (about 30 minutes). Ready solution(in vials) can be administered without dilution or diluted in isotonic solution sodium chloride or 5% glucose solution. The concentrate of the infusion solution (in ampoules of 10 ml of a 1% solution) must be diluted before administration.

In acute gonorrhea and uncomplicated cystitis (inflammation of the bladder), women are prescribed ciprofloxacin orally at a single dose of 0.25 g and intravenously at a dose of 0.1 g.
Doses for intravenous administration for uncomplicated urinary tract infections, 0.1 g 2 times a day, in other cases, 0.2 g 2 times a day. If the patient's condition improves, they switch to taking the drug inside.

Indications

Infections of the respiratory tract, skin and soft tissues, bones and joints, gastrointestinal tract, including infections caused by salmonella, shigella, campylobacter and other pathogens;
- gonococcal infections, meningitis / inflammation of the meninges /, postoperative infectious complications, sepsis / infection of the blood with microbes from the focus purulent inflammation/ and other purulent-inflammatory processes).
The drug is highly effective in urinary tract infections; when ingested, it quickly penetrates the kidneys, is excreted for a long time, and has a bactericidal (destroying bacteria) effect on Pseudomonasaeruginosa (the dominant pathogen in complicated urinary tract infections).
The drug is indicated in the treatment of infections in cancer patients.

Contraindications

Hypersensitivity to quinolones, epilepsy.
- pregnant, lactating women, children and adolescents with incomplete skeleton formation (up to 15 years).
- in case of impaired renal function, first give usual doses, and then they are reduced taking into account creatinine clearance (the rate of blood purification from the final product nitrogen metabolism- creatinine).
- Ciprofloxacin should not be taken concomitantly with antaioid (reducing stomach acid) agents (including alkaline waters) to avoid loss of efficiency.

Side effects

The drug is usually well tolerated. In some cases, there are allergic reactions (pruritus, rash); possible development of facial edema, vocal cords; anorexia (lack of appetite), abdominal pain, nausea, vomiting, diarrhea; sleep disturbances, headache, anxiety, general depression; changes in the blood picture: leukopenia (decrease in the level of leukocytes in the blood), agranulocytosis ( a sharp decline the number of granulocytes in the blood), thrombocytopenia (a decrease in the number of platelets in the blood).

In rare cases, the perception of smell and taste is disturbed. When using ciprofloxacin, as well as other fluoroquinolones, one should not be exposed to ultraviolet rays due to possible photosensitivity (increased sensitivity to sunlight) skin.

Release form

Coated tablets, 0.25; 0.5 and 0.75 g; 0.2% solution in infusion bottles of 50 and 100 ml (100 or 200 mg); 1% solution in 10 ml ampoules (concentrate to be diluted).

ATTENTION!

The information on the page you are viewing was created for informational purposes only and does not promote self-treatment in any way. The resource is designed to familiarize healthcare professionals with additional information about certain medicines, thereby increasing the level of their professionalism. The use of the drug "" in without fail provides a consultation with a specialist, as well as his recommendations on the method of application and dosage of the medicine you have chosen.

Group: quinolones, fluoroquinolones

Indications:
- diseases of the lower respiratory tract (acute and chronic (in the acute stage) bronchitis, pneumonia, bronchiectasis, infectious complications of cystic fibrosis);
- infections of ENT organs (acute sinusitis);
- kidney infections and urinary tract(cystitis, pyelonephritis);
- complicated intra-abdominal infections (in combination with metronidazole), incl. peritonitis;
- chronic bacterial prostatitis;
- uncomplicated gonorrhea;
- typhoid fever, campylobacteriosis, shigellosis, traveler's diarrhea;
- infections of the skin and soft tissues (infected ulcers, wounds, burns, abscesses, phlegmon);
- bones and joints (osteomyelitis, septic arthritis);
- septicemia;
- infections against the background of immunodeficiency (occurring in the treatment of immunosuppressive drugs or in patients with neutropenia);
- prevention of infections during surgical interventions;
- prevention and treatment of pulmonary anthrax;

Contraindications:
Hypersensitivity to ciprofloxacin and other quinolone drugs, pregnancy and lactation, age up to 15 years, epilepsy, diseases of the central nervous system with a decrease in convulsive threshold.

Side effects:
From the side digestive tract: nausea, vomiting, diarrhea, abdominal pain, flatulence, increased activity of hepatic transaminases, bilirubin;
From the side of the central nervous system: headache, dizziness, sleep disturbance, hallucinations (these reactions require immediate discontinuation of the drug), loss of consciousness, blurred vision (split vision), tinnitus, temporary hearing loss in the high frequency range;
From the urinary system: crystalluria, dysuria, polyuria, albuminuria, hematuria, transient increase in serum creatinine content;
On the part of the blood formation system: eosinophilia, leukopenia, neutropenia, a decrease in the number of platelets, anemia;
From the side of the cardiovascular system: tachycardia, cardiac arrhythmias, arterial hypotension;
Allergic reactions: pruritus, urticaria, angioedema, Stevens-Johnson syndrome, arthralgia, photosensitivity;
Others: with intravenous administration - soreness along the vein, phlebitis, vasculitis, candidiasis;

Pharmacological properties:
A broad-spectrum antimicrobial agent from the group of fluoroquinolones. Has a bactericidal effect. Inhibits bacterial DNA hydrase. It acts on microorganisms during the period of division and dormancy.
Highly active against many gram-negative and gram-positive bacteria (including strains resistant to penicillins, cephalosporins and aminoglycosides): Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, N.gonorrhoeae, many strains of Staphylococcus spp. (producing and not producing penicillinase, methicillin-resistant), some strains of Enterococcus spp., as well as Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp. Ciprofloxacin is active against bacteria that produce beta-lactamase.
Resistant to ciprofloxacin Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Action against Streptococcus faecium and Treponema pallidum insufficiently studied.
Ciprofloxacin is rapidly absorbed from the digestive tract. Bioavailability after oral administration is 70%. Food intake moderately slows down its absorption, but does not change its bioavailability.
Plasma protein binding - 20-40%. It undergoes the effect of primary passage through the liver. Widely distributed in tissues and biological fluids organism, which distinguishes it from aminoglycosides and beta-lactam antibiotics, which have a small volume of distribution.
Creates high concentrations in prostate, lungs, bone tissue, bronchial secretion, bile. Penetrates through the placenta, excreted in breast milk.
It is excreted in the urine and bile, mainly unchanged. The half-life is 3-5 hours.
In patients with impaired renal function, the concentration of the drug in blood plasma and the half-life increase. Significant concentrations of the drug, exceeding the MIC for most sensitive bacteria, persist in the urine and feces for several days after cessation of therapy.

Dosage and administration:
Coated tablets film sheath:
Inside, regardless of the meal. The dose is set individually depending on the severity of the infection, age, body weight and kidney function of the patient.
Recommended doses for adults:
Respiratory tract infections: 500-750 mg. 2 times a day.
Infections of the skin and soft tissues, bones and joints: 500-750 mg. 2 times a day.
Digestive tract infections: 250-500 mg. 2 times a day.
Gonorrhea: 250 mg. inside once.
Non-gonococcal urethritis: 750 mg. 2 times a day.
Chancroid: 500 mg. 2 times a day.
Other infections: 500-750 mg. 2 times a day.
Patients should drink plenty of water during treatment.
The drug is not recommended for children. If expected therapeutic effect exceeds potential risk, the drug can be prescribed at a dose of 5-10 mg / kg. per day in 2 doses.
Duration of treatment acute infections is 5-7 days. Therapy should be continued for another 3 days after the disappearance of symptoms of infection.
Solution for infusion:
Adults and children over 15 years of age are prescribed intravenously by drip without dilution. The dosage is set individually depending on the location and course of the infection, as well as the sensitivity of microorganisms.
A single dose is 100 - 400 mg. 2 times a day. The course of treatment is 7-10 days, with severe and mixed infections the duration of treatment is increased.
For infections of the urinary tract, ENT organs, bones and joints, 200-400 mg are administered. 2 times a day.
With intra-abdominal infections and septicemia, diseases of the skin and soft tissues - 400 mg. 2 times a day.
The duration of the infusion is 30 minutes with the introduction of the drug at a dose of 200 mg. and 60 minutes - when administered at a dose of 400 mg.
In case of impaired renal function, ciprofloxacin is first administered at a dose of 200 mg, and then taking into account creatinine clearance (if the clearance is less than 20 ml / min, a single dose should be 50% of the average dose with a multiplicity of appointments 2 times a day or the usual single dose administered 1 time per day).
For elderly patients, the dose should be reduced (usually by 1/3).

Release form:
Film-coated tablets 250 mg., 500 mg. and 750 mg. 10 pieces in a blister, 1 or 2 blisters in a carton.
Solution for infusion 2 mg/ml. 100 and 200 ml. in glass bottles, 100 and 200 ml. in glass bottles in a pack of cardboard, 100 and 200 ml. in polymer containers.

Interaction with other drugs:
With the simultaneous use of ciprofloxacin with didanosine, the absorption of ciprofloxacin is reduced due to the formation of complexes of ciprofloxacin with the aluminum and magnesium salts contained in didanosine. Simultaneous reception Ciprofloxacin and theophylline can lead to an increase in the concentration of theophylline in blood plasma, due to competitive inhibition in the binding sites of cytochrome P 450, which leads to an increase in the half-life of theophylline and an increase in the risk of developing toxic action associated with theophylline. Simultaneous administration of antacids, as well as preparations containing aluminum, zinc, iron or magnesium ions, can cause a decrease in the absorption of Ciprofloxacin, so the interval between the appointment of these drugs should be at least 4 hours. With the simultaneous use of Ciprofloxacin and anticoagulants, the bleeding time is prolonged. With the simultaneous use of ciprofoxacin and cyclosporine, the nephrotoxic effect of the latter is enhanced.

Attention! Before using the drug CIPROFLOXACIN, you should consult your doctor.
The instructions are provided for informational purposes only.