Afobazole single dose for adults. How to take Afobazol tablets: instructions for use and reviews of people. Influence on the ability to control mechanisms

Afobazole is a sedative that is intended for long-term use. It is used for various nervous disorders and can be bought at a pharmacy without a prescription. Before starting a course of treatment, you should consult a specialist, because human psyche- an extremely delicate mechanism.

The medicine belongs to the group of anxiolytics, i.e. psychotropic drugs with sedative and antipsychotic effect. It is used to reduce anxiety, improve sleep, reduce aggressiveness in mild forms of neuroses.

The principle of action of the drug is the effect on the receptors of γ-aminobutyric acid (GABA). This substance is an inhibitory mediator, and Afobazol enhances the susceptibility of receptors to it. Thus, in the brain are restored normal processes inhibition, which balance excessive excitability.

The receptors affected by the drug are located in the areas of the cortex responsible for fine motor skills, memory and emotions. Due to the neuroprotective action and the normalization of inhibitory processes, Afobazole can also have a slight stimulating effect. It manifests itself with regular intake - after a decrease in the level of anxiety, sleep normalizes, the patient feels rested, working capacity increases, and mood improves.

The drug is not addictive, but shows maximum effectiveness only with regular use.

The duration of the course should be clarified with the doctor. Effectively fights against suspiciousness, anxiety, mood instability, increased vulnerability and sleep disorders.

Description of the dosage form and composition

The main active ingredient of the drug is afobazole. It is an anxiolytic (tranquilizer), belonging to the group of non-benzodiazepine. The classification of anxiolytic drugs is based on the type of receptor they act on. For Afobazole, the main target is GABAergic receptors. The impact on them is milder, which gives fewer side effects than treatment with benzodiazepine drugs.

The drug is available in tablets intended for use during the course. In addition to the main substance, the tablet contains auxiliary components - potato starch, cellulose, magnesium stearate and other agents necessary to ensure that the tablet is convenient to take and easy to digest.

Instructions for use

The drug Afobazole is prescribed for the following disorders:

• anxiety states, including neuroses and obsessive anxiety, as well as those caused by somatic diseases (CHD, dermatitis, etc.);
• sleep disturbances caused by anxiety disorders;
• cardiopsychoneurosis;
• cyclic syndrome in women;
• withdrawal syndrome;
• various dependencies.

The drug can also be used for subjective feeling heightened anxiety, insomnia, suspiciousness and hypochondria. For those who decide to prescribe a medicine for themselves, it is especially important to follow the instructions.

Tablets are taken orally after meals. A single dose is 10 mg (this is 1 tablet of 10 mg or 2 tablets of 5 mg). You need to drink Afobazole three times a day at approximately equal intervals. Strict observance of intervals is not necessary, but desirable. The duration of the course of treatment is from 2 to 4 weeks (about 1 pack of tablets).

The doctor can change the regimen depending on the characteristics of the course of the disease in a particular patient. It is not recommended to extend the course for more than 4 months. If taking Afobazole does not bring relief, the patient should consult a doctor to select another drug.

Contraindications and side effects

Unlike most benzodiazepine anxiolytics, Afobazole has a fairly small amount side effects and contraindications. Nevertheless, there are a number of situations in which you can not drink this drug. These include:

• intolerance to the components of the drug;
• intolerance to sugars - monosaccharides, galactose;
• galactosemia;
• children's and adolescence(up to 18 years old);
• pregnancy and lactation.

The drug is prescribed with caution to patients with diabetes and other pathologies carbohydrate metabolism.

In diseases of the kidneys, which are accompanied by a decrease glomerular filtration dosage needs to be reduced.

Side effects are most often manifested in the form of allergic reactions - skin itching, rashes, rhinitis, vascular pathologies. Short-term digestive disorders are possible - abdominal pain, nausea and vomiting.

An overdose develops with a single dose of 40-50 mg or more. It is manifested by drowsiness, decreased motor activity, apathy, fatigue. Severe cases of poisoning are rarely recorded and are manifested by depression of consciousness, a significant decrease in muscle tone, drop in blood pressure. In such cases, injections of caffeine-sodium benzoate are prescribed, which are carried out in a hospital.

Which is better: Afobazol or ...

In pharmacies you can find a lot sedatives sold without a prescription, from plant extracts(valerian, motherwort, peony) to synthetic drugs, which include Afobazole. How to make a choice?

Tenoten

Tenoten contains purified antibodies to the S-100 protein produced in the brain. The medicine is homeopathic, nevertheless it is quite popular, although its effectiveness is largely debatable. Available in tablets.

It is prescribed for the same diseases as Afobazol, but does not have a sedative effect, only anti-anxiety. Unlike Afobazole, it is available in two dosage forms - for adults (from 18 years old) and for children (from 3 years old, children's Tenoten). It has the same list of contraindications as Afobazole - intolerance and carbohydrate metabolism disorders. Side effects with proper use do not develop.

In mild anxiety disorders, there are no significant differences in effectiveness, they appear with relatively serious illnesses, in this case, Afobazol is more effective than Tenoten.

Persen is a combination of herbal extracts that comes in tablet form. The effect is sedative, anti-anxiety and antispasmodic. Because of the latter, Persen is more effective at vegetative dystonia, violations of vascular tone and migraines.

Unlike Afobazole, it has a longer list of contraindications - allergies to it are more common, it should not be taken by patients with diseases of the liver and kidneys, and used with caution in pathologies of carbohydrate metabolism.

Persen is acceptable for children over 12 years old, but unlike Afobazole, it cannot be used for arterial hypotension (Afobazole does not affect blood pressure).

Phenibut

The active substance of Phenibut is γ-amino-β-phenylbutyric acid, which is converted into GABA in the body. Unlike Afobazole, Phenibut increases the content of GABA in brain cells, but does not affect the sensitivity of receptors to it.

Has more wide range applications than Afobazol: disorders of memory, thinking, emotional sphere, fine motor skills. With anxiety and insomnia, the use of Afobazole and Phenibut gives a comparable result. Phenibut is also used for pain syndromes caused by lesions of the spine - cervical, lumbar osteochondrosis.

Unlike all the drugs listed above, Phenibut does not contain lactose, so it can be taken in case of violations of the digestion and metabolism of carbohydrates. In addition, it is allowed for children from 8 years old. Unlike Afobazol, it requires more caution in diseases of the gastrointestinal tract.

Adaptol

Adaptol is a so-called daytime tranquilizer. Its action is not accompanied by muscle weakness and drowsiness; during the course of treatment, you can not interrupt work. In this case, the drug enhances the effect of drugs used to treat insomnia. This is due to the normalization of the emotional state of the patient.

Like Afobazole, it is used in the treatment of addictions and neuroses. More commonly used to treat pain caused by nervous disorders. Virtually no contraindications, except hypersensitivity. Unlike Afobazole, Adaptol can be used for violations of carbohydrate pressure. Designed for children from 10 years old.

Another representative of the group of daytime anxiolytics. It has the same range of applications as Afobazol. More effective for somatic pain caused by neurosis, premenstrual syndrome and postmenopausal pathologies.

Unlike Afobazole, Grandaxin cannot be used for depression and psychomotor agitation, aggressiveness.

It can be used during pregnancy (except for the 1st trimester), carefully - for violations of carbohydrate metabolism and kidney disease. It is dangerous to use in diseases of the respiratory system, with the syndrome of respiratory arrest during sleep, taking Grandaxin is prohibited.

Glycine

Glycine is an amino acid that has a neuroprotective effect and is one of the neurotransmitters. Glycine enhances the processes of inhibition in the nervous system, due to which its sedative effect is manifested. It is prescribed for stress, syndrome chronic fatigue, neurosis and treatment of withdrawal symptoms. It is acceptable for use in adolescents and children over 3 years of age. It is considered the safest of all drugs of this kind.

Atarax

It is used for the treatment of neurosis, anxiety disorders, skin itching, as well as for premedication (preparation for anesthesia). Hypersensitivity to this remedy, as well as related ones, often occurs, so its administration requires more careful consideration of contraindications. Not intended for children, pregnant or lactating women. The active substance is able to pass through the placental barrier.

Afobazole is a fairly safe and effective drug for neurosis and anxiety. It has a fairly wide range of analogues, so if there are contraindications, you can choose a replacement for it.

Vegetovascular dystonia is a disease of the modern lifestyle. Stressful situations, emotional upheavals, anxiety - all this leads to the failure of internal organs. Eliminate unpleasant symptoms in a medical way with sedatives and sedatives. "Afobazole" is considered effective for VVD.

Release form and composition

The country of origin of Afobazol is Russia. The drug is produced in the form:

• tablets of white or yellowish shade with a risk, with the content of the active substance (fabomotizol) - 5 mg;
• tablets of white or cream color with a risk, with the content of the active substance (fabomotizol) - 10 mg.

Tablets are sold in sealed blisters of 10 pcs. The package comes with 30 to 60 pieces.

Afobazol for VVD is one of the most prescribed drugs, although it has no direct connection with cardiological problems.

Auxiliary components:

• starch;
• lactose;
• magnesium;
• cellulose;
• povidone.

Pharmacological action of the drug "Afobazol" from VVD

According to the instructions, the tool has the following actions:

1. Eliminates feelings of fear and anxiety.
2. Stimulates the functions of the central nervous system.
3. Increases the resistance of nerve cells.
4. Calms the nervous system.
5. Restores psychological well-being.
6. Improves memory, mental and physical performance.
7. Reduces the manifestation of autonomic disorders (vomiting, nausea, sweating, dry mouth, weakness).

"Afobazol" refers to pharmacological group anxiolytic agents. Once in the body, the active ingredients are absorbed into the walls of the stomach and enter the bloodstream. The therapeutic effect occurs 20 minutes after taking the pill. The active ingredients are metabolized in the liver. They are displayed naturally along with urine and feces.

Afobazole helps to quickly calm down in stressful situations, that is, for people with increased nervous excitability, this drug will become an indispensable assistant

Indications for use

Afobazole is often prescribed for VVD and panic attacks, but there are other indications:

• anxiety states: signs of complicated neurasthenia, various psycho-emotional disorders;
• diseases that occur with somatic disorders - headaches, problems with the stomach or intestines, pressure surges;
• oncological neoplasms;
• heart problems;
• insomnia, sleep disturbance due to obsessive thoughts, nightmares;
• alcohol addiction;
• hypertension;
• dermatological diseases;
• premenstrual syndrome;
• alcohol withdrawal syndrome.

"Afobazol" is a tranquilizer, it is forbidden to take it without the knowledge of a doctor. Treatment is prescribed in each case individually, taking into account the type of disease, the severity of symptoms, the age of the patient.

Contraindications

Like all drugs, Afobazole should not be taken if there are contraindications:

• Individual sensitivity to one of the substances. With hypersensitivity of the body, treatment will do more harm than good. To avoid serious complications, you should be tested and undergo an appropriate examination.

Afobazole should not be taken by expectant and nursing mothers

• Lactose intolerance. In this case, you can choose an analogue.
• Age up to 18 years. The central nervous system is not yet fully formed, so the medicine can cause irreparable harm.
• Pregnancy and lactation period. The active ingredients penetrate the placenta and adversely affect the central nervous system of the child, causing the development of defects. However, tranquilizer treatment may be administered in III trimester if the possible benefit to the mother outweighs the risk of complications in the child. Active components also enter breast milk, reducing its quality indicators.

Instructions for use

How to drink pills for VVD and panic attacks? During therapy, you should follow the basic rules:

1. The tablets should only be taken with water. Juices, teas and coffee reduce the effectiveness of the drug.
2. The active ingredients irritate the walls of the stomach, so you need to take the medicine after a meal.
3. The dosage is prescribed by the doctor depending on the type and severity of the disease. On average, 1 tablet (10 mg) is prescribed 3 times a day. An equal interval of time should be observed between doses. With pronounced symptoms, the average daily rate increases to 60 mg per day.
4. The standard course of treatment is 2-4 weeks. If necessary, the course can be repeated after 3 weeks.

Afobazole is drunk after eating

"Afobazole" has a mild effect, so there is no need to gradually reduce the dosage in order to cancel the medication. You can stop taking the tranquilizer at once and this will not affect the patient's well-being. Improvements are observed a week after the start of the course. However, you should not interrupt the course, otherwise the symptoms will worsen again.

Overdose

The drug does not accumulate and is quickly excreted from the body. But at long-term treatment or taking a large dose of a tranquilizer can cause an overdose. In this case, it is possible to develop sedative action and increased drowsiness without muscle relaxation. If these symptoms appear, you should immediately call a doctor for the purpose of subcutaneous administration of caffeine-sodium benzoate 20%.

special instructions

The active substances do not adversely affect the functioning of the central nervous system and do not reduce the speed of psychomotor reactions, therefore, during treatment, a person can drive any vehicle and perform work that requires concentration. "Afobazol", on the contrary, improves memory and attention.

A significant overdose of the drug is also a contraindication. As a result of this phenomenon, a person has drowsiness, apathy, indifference to the events taking place around

"Afobazol", like other tranquilizers, causes a number of side effects:

• diarrhea
• vomiting;
• nausea;
• allergic rashes and itching on the body;
• headache;
• pronounced sexual desire.

If the above symptoms appear, you should stop taking the medicine and consult a doctor to adjust the therapy.

Interaction with other drugs

"Afobazole" is well tolerated by patients, but can it be combined with other drugs? It is forbidden to combine a tranquilizer with:

• "thiopental";
• "Carbamazepine";
• "Diazepam".

"Afobazole" enhances the anticonvulsant, anxiolytic effect of drugs. During treatment, you should also stop drinking alcohol.

All these drugs also have their own characteristics, so you can not independently replace Afobazole with other drugs that belong to anxiolytic drugs

The drug Afobazole belongs to the category of anxiolytics (tranquilizers) of selective action. It has a non-bezodiazepine structure, due to which it has a moderate activating effect in combination with relief of increased anxiety. Afobazole has a very mild effect compared to benzodiazepines. The use of the drug does not cause drug dependence. After the end of the course, the withdrawal of the tranquilizer does not develop withdrawal syndrome. The method of application, the dose is prescribed by the doctor on an individual basis.

Release form

Afobazol - effective popular pharmacological drug, which is prescribed for adults to normalize the psycho-emotional background, relieve anxiety, eliminate the effects of stress, and reduce the frequency of autonomic disorders.

Tranquilizer is available in the form of light cream tablets, white color. Designed for oral administration. Available in pharmacies without a prescription.

Flat-cylindrical tablets are chamfered, packed in aluminum blisters of 10-25 pieces. The blisters are placed in cardboard packaging along with instructions for use. Also, the drug is produced in polymer, glass jars of 30, 50, 100, 120, 150 pieces, which are sealed with self-tight lids.

The main active ingredient on the basis of which Afobazole was created is fabomotizol (morpholinoethylthioethoxybenzimidazole) in an amount of 5 mg or 10 mg in one tablet.

Tablets of 5 mg are usually called "Afobazole 5", and with a dosage of 10 mg - "Afobazole 10".

Excipients:

1. Potato starch;
2. Microcrystalline cellulose;
3. lactose monohydrate;
4. Povidone medium molecular weight (collidon 25);
5. magnesium stearate.

Auxiliary components are included in all dosages of the tablet preparation.

Afoblazol tablets for strict observance dosage does not cause addiction, side effects, complications.

Store the tranquilizer in a dry, cool, dark place at temperatures up to 22-25 degrees in the original packaging. From the date of production, the shelf life is two years. After the expiration of this period, the drug is disposed of.

Pharmacological properties

Main active substance tablets Afobazole has a pronounced anxiolytic effect, relieves feelings of anxiety, excitement. It does not affect benzodiazepine receptors, therefore it does not cause drowsiness, does not relax striated muscles (muscle relaxation), does not impair memory, and does not reduce concentration.

Important! The active component of afobazole is a derivative of 2-mercaptobenzimidazole, which belongs to the group of selective anxiolytics. It is not a benzodiazepine receptor antagonist. Therefore, afobazole does not affect benzodiazepine receptors in the brain.

At correct reception Afobazole does not cause physical and psychological dependence.

The active substance has an activating anxiolytic effect, improves the quality of night sleep, improves mood, reduces feelings of anxiety, excitement, fear, relieves tension, promotes relaxation. Afobazole also relieves somatic, cognitive, vegetative disorders (sensory, gastric, intestinal symptoms, chills, dry mouth), reduces muscle spasms, eliminates other vegetative-somatic disorders.

It should be noted that this tranquilizer does not provoke CNS inhibition. Patients do not feel lethargy, daytime sleepiness, lethargy after taking.

The drug Afobazole reduces muscle spasms, eliminates excessive sweating, dry mouth, and other vegetative-somatic disorders.

Maximum effect after taking the drug, they are noted, as a rule, on the fourth or fifth week from the start of the treatment course. In this case, the result is stored for 14-18 days after cancellation.

To a greater extent, the anxiolytic effect of Afobazole is pronounced after taking it in patients with asthenic character traits (too suspicious, impressionable, anxious people, people with increased emotional lability).

According to the instructions, Afobazole does not belong to the group of toxic drugs. It is rapidly absorbed after ingestion in the gastrointestinal tract, spreads with the bloodstream and is evenly distributed in the tissues. Excreted from the body with stool through the kidneys. The half-life is approximately 40-50 minutes.

Indications for use

Afobazole is prescribed for adults as a sedative, sedative drug. A tranquilizer simultaneously has an anti-anxiety and stimulating effect. Quickly relieves anxiety, reduces stress, normalizes the emotional and psychological state.

Afobazole tablets are prescribed for:

• neurasthenia different nature, etiogenesis;
• sleep disturbances, insomnia caused by anxiety, impaired adaptation;
• vegetovascular dystonia;
• neurocirculatory dystonia;
• generalized anxiety;
• oncology;
• chronic somatic diseases that alternate between a state of rest and excitability ( bronchial asthma, ischemic disease);
• dermatoses that provoke psychosis in a person (psoriasis, eczema);
• premenstrual tension syndrome;
• depression in moderate, severe, mild form;
• alcohol withdrawal syndrome.

The tranquilizer Afobazole is especially effective in relieving anxiety in patients suffering from cardiovascular pathologies and diseases. This is the best drug that will help cope with fears, phobias, tearfulness, tension, insecurity, depression.

Taking Afobazol tablets shows nice results in complex therapy somatic pathologies(bronchial asthma, allergic bronchospasm, coronary heart disease, arrhythmia, tachycardia).

The drug Afobazole relieves the condition of people who have quit smoking. Normalizes blood pressure.

Dosages

Dosage, frequency of taking the drug, the duration of the course depends on age, general condition patient, stage, form, type of disease, individual characteristics organism. The dose is selected individually in each case.

The average recommended therapeutic dose of a tranquilizer is 10 mg three times a day (30 mg). By medical indications the daily dosage is increased to 50-60 mg. Afobazol tablets should be taken after meals. Dragee without chewing, drink a small amount boiled or still water. Between doses, observe approximately the same time intervals.

As a rule, the duration of the treatment course is two to four weeks. If necessary, therapy is extended by the attending physician. The maximum allowable duration of a continuous course is three months. Treatment with afobazole can be continued no earlier than a month later.

You can evaluate whether the drug is suitable for you already on the fifth or sixth day of taking it. If the result is absent or slightly pronounced, you can cancel afobazole and start treatment with another medication.

Before the end of therapy, there is no need to reduce the dose of Afobazole, since the drug is not addictive, there is no withdrawal syndrome. Adverse symptoms also occur in extremely rare cases.

Side effects

Side effects are noted with excessive abuse of the tranquilizer, non-compliance with the instructions indicated in the instructions. therapeutic dosage, as well as in case of increased hypersensitivity to the components of the drug.

Afobazole can provoke skin rash, allergies, urticaria, itching, dry mouth, sneezing. A rather unusual side effect that develops after taking the drug can be called an increase in sexual desire. But in general, these are just consequences of reducing anxiety.

Important! An overdose of afobazole manifests itself in the form of drowsiness, but without muscle relaxation.

The drug Afobazole does not affect the speed of driving cars, does not cause lethargy, does not reduce, does not disperse attention.

Compatibility with other drugs and alcohol

Afobazol instructions for use states that the tranquilizer does not enhance toxic effect alcohol, does not affect the narcotic effect of ethanol, does not increase the hypnotic effect of thiopental when used together.

But still, for the duration of treatment, refuse to take any alcoholic beverages and especially drugs, especially in the presence of cardiovascular pathologies, neurology. Otherwise, the course of somatic pathology worsens.

It should be noted that Afobazol tablets are often used to eliminate the withdrawal syndrome, which in most cases is accompanied by a depressive state, guilt, which can turn into psychosis. A tranquilizer stops the painful psychological symptoms of a hangover syndrome, facilitating the exit from this state, protects the gastrointestinal mucosa from the irritating effects of alcohol, reducing its absorption. In addition, Afobazole accelerates the processes of removing alcohol decay products from the body, eliminates apathy, and increases efficiency after long parties.

Advice! To eliminate a hangover, the drug is taken twice a day, 10-20 mg.

Afobazole enhances the anticonvulsant effect of carbamazepine, the anti-anxiety effect of diazepam.

When switching from Afobazole to others medications with a similar effect on the body, it must be borne in mind that this tranquilizer retains its therapeutic efficacy for up to two weeks. Therefore, it is advisable to wait for this period for an adequate assessment therapeutic action new drugs.

Contraindications for use

Afobazole has a number of contraindications, which are indicated in the instructions for the medication.

Contraindications to taking afobazole:

• individual sensitivity to the components of the drug;
• galactose intolerance;
• deficiency of lactase in the body;
• pregnancy, breastfeeding kids.

Afobazole is not used in medical therapy patients who are under 18 years of age.

Tranquilizer analogs

Similar in severity of therapeutic effect, as well as in active ingredient Afobazol tablets is a drug Fabomotizol.

The following also have the most similar effect to afobazole: Mebix, Tenoten, Mebicar, Divaza, Adaptol, Fezanef, Fezipam (tablets), Noofen, Stresam (capsules), Fenorelaxan, Elzepam (tablets, injections), Selank (nasal drops).

It is difficult to say what is better than Afobazol or its analogues. Efficiency depends not only on the duration of treatment, but also on the individual characteristics of the human body. Some patients are more suitable for one medication, for others other medications are more effective. Therefore, doctors always try to choose the most optimal medication for the treatment of neurological or any other systemic diseases. But self-medication, uncontrolled reception pharmacological agents can cause serious complications and consequences for the body. Therefore, when choosing a sedative, an antidepressant, be sure to consult a doctor.

Before you buy a tranquilizer Afobazol, we recommend that you carefully study the proposed instructions, which describe the dosage, methods of application, and the concomitant effect on the human body of this medication. It must be borne in mind that only a doctor can professionally correlate the patient's problem and the restriction to taking Afobazol, so you should not self-medicate.

The website "Psychology and Psychiatry" offers all important information on the following issues: indications and instructions for the use of Afobazole, recommended dosage, contraindications, popular analogues, reviews of patients and doctors.

Afobazole is a drug from the group of anxiolytics (tranquilizers) of a non-bezodiazepine structure, which has a moderate activating effect in combination with the relief of anxiety. Afobazole has a very mild effect compared to benzodiazepines, does not cause the development of drug dependence and does not provoke withdrawal syndrome after discontinuation. The drug is used to treat anxiety in adults caused by various factors(for example, an upcoming operation, experienced stress, etc.) or mental disorders (for example, generalized, impaired adaptation, etc.).

Afobazole - composition, form of release, packaging

fabomotizole (as dihydrochloride) 5 mg

Excipients: potato starch - 48 mg, microcrystalline cellulose - 40 mg, lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone, collidone 25) - 7 mg, magnesium stearate - 1.5 mg.

Tablets white or white with a creamy tint, flat-cylindrical, with a chamfer.

fabomotizole (as dihydrochloride) 10 mg

Excipients: potato starch - 48 mg, microcrystalline cellulose - 35 mg, lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone, collidone 25) - 7 mg, magnesium stearate - 1.5 mg.

Afobazole - pharmacological action

The pharmacological action of the drug is anxiolytic.

Pharmacodynamics

Afobazole is a selective non-benzodiazepine anxiolytic. Acting on σ1 receptors in nerve cells brain, Afobazole stabilizes GABA / benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators. Afobazole also increases the bioenergetic potential of neurons and has a neuroprotective effect: it restores and protects nerve cells.

The action of the drug is realized mainly in the form of a combination of anxiolytic (anti-anxiety) and light stimulating (activating) effects. Afobazol reduces or eliminates anxiety (concern, bad forebodings, fears), irritability, tension (shyness, tearfulness, anxiety, inability to relax,), depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal symptoms), autonomic disorders(dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory), including those arising from stress disorders (disorders). Especially indicated is the use of the drug in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, propensity for emotional stress reactions.

The effect of the drug develops on the 5-7th day of treatment. The maximum effect is achieved by the end of the 4th week of treatment and persists after the end of treatment for an average of 1-2 weeks.

Afobazole does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and. It does not form addiction when used. drug addiction and the syndrome of "cancellation" does not develop.

Pharmacokinetics

Suction

After oral intake Afobazole is well and rapidly absorbed from the gastrointestinal tract. Cmax in plasma - (0.13±0.073) µg/ml; Tmax - (0.85±0.13) h.

Distribution

Afobazole is intensively distributed over well-vascularized organs, it is characterized by rapid transfer from the central pool (blood plasma) to the peripheral (highly vascularized organs and tissues).

Metabolism

Afobazole undergoes the effect of the first passage through the liver, the main directions of metabolism are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment.

breeding

T1 / 2 of the drug Afobazole when taken orally is (0.82 ± 0.54) hours. Short T1 / 2 is due to the intensive biotransformation of the drug and rapid distribution from blood plasma to organs and tissues. The drug is excreted mainly in the form of metabolites and partly unchanged in the urine and feces.

Afobazole - indications for use

Afobazole is used in adults for anxiety conditions, namely:

- generalized anxiety disorders;

- neurasthenia;

- Adjustment disorders.

In patients with various somatic diseases, namely:

- bronchial asthma;

- irritable bowel syndrome;

- systemic lupus erythematosus;

— hypertonic disease;

- arrhythmias;

- dermatological, oncological and other diseases.

During treatment:

- sleep disturbances associated with anxiety;

- neurocircular dystonia;

- premenstrual syndrome;

- to alleviate the "withdrawal" syndrome when quitting smoking.

Afobazole is most effective in eliminating anxiety in cardiovascular diseases, premenstrual syndrome and neurocirculatory dystonia. According to scientists, this particular drug is the best way to relieve depression, tearfulness and depression inherent in people suffering from heart disease.

Afobazole - dosage

Afobazol tablets can be taken immediately in full dosage, and not increasing it gradually, since they have a mild effect, as a result of which it does not take time for the body to "get used" to the drug.

You can also abruptly, immediately stop taking Afobazol, such as conventional cough, headache, etc. tablets. It is not necessary to gradually reduce the dosage of Afobazole for the purpose of subsequent withdrawal of the drug. The ability to immediately stop taking the drug at any time is due to the fact that it does not cause drug dependence in humans, and, consequently, the withdrawal syndrome, which is very difficult to tolerate and is a real "scourge" of benzodiazepine tranquilizers.

Such an opportunity to start taking the drug immediately in the required full dosage and, if necessary, immediately stop taking it, makes Afobazol very simple and affordable to use. There is no need to first increase the dosage of the drug for 2-3 weeks to the required one, and after the end of the course of therapy, also slowly reduce it with a view to subsequent complete cancellation.

In addition, the ease of use of Afobazole allows you to take it in a trial mode - that is, drink tablets for 4-5 weeks, wait for the full therapeutic effect to develop and evaluate whether this drug is right for you. If suitable, then you can simply continue to take it, and if not, then stop taking it on the same day and switch to other drugs.

When switching from Afobazole to other anti-anxiety drugs, it should be remembered that its effects persist for 1 to 2 weeks. Therefore, in order to avoid unwanted reactions, it is recommended to start taking another drug 2 weeks after the abolition of Afobazole.

Afobazole after completion of therapy with other tranquilizers can be taken after 7 to 10 days.

Afobazol - how to take it correctly

Tablets should be taken after meals, swallowing them whole, not chewing, biting or crushing in any other way. The tablet should be washed down with a small amount of pure non-carbonated water.

It is optimal to take Afobazole 10 mg (1 tablet of 10 mg or 2 tablets of 5 mg) 3 times a day, observing approximately equal intervals between doses. With this mode of administration, a single dosage is 10 mg, and a daily dose is 30 mg.

The duration of standard therapy is usually two to four weeks, after which it is necessary to stop taking the drug. After 4 weeks, it will be possible to undergo treatment with Afobazol again.

If necessary, and only under the supervision of a doctor, you can increase the dosage of Afobazole to 20 mg three times a day, and the duration of continuous therapy - up to three months. However, any increase in dosage of more than 10 mg and the duration of taking the drug for more than 4 weeks should be made only after consulting a doctor.

It should be remembered that Afobazole can be used in repeated courses, observing an interval of at least 4 weeks between them.

Afobazole - contraindications and side effects

Contraindications to taking the drug are as follows:

- Individual intolerance to the drug;

- Galactose intolerance, lactase deficiency or glucose-galactose malabsorption;

- Pregnancy, lactation;

— Children's age up to 18 years;

- The use of the drug Afobazol is contraindicated during pregnancy.

If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

As side effects, Afobazole is able to provoke various allergic reactions and headache, which, as a rule, goes away on its own, without requiring special treatment and drug withdrawal. Some people note the appearance of a pronounced intimate desire a few days after the start of taking Afobazole. Doctors and scientists do not attribute this effect to a side effect, but associate the appearance of libido with relief of tension and anxiety.

What is better than Afobazole - Persen or Novopassit?

Persen and Novopassit are natural vegetable sedatives with an almost identical spectrum of therapeutic effect, designed to relieve anxiety, anxiety and other purely psychological unpleasant symptoms and manifestations associated with increased anxiety.

Afobazole is a drug designed to relieve severe anxiety, as well as associated not only unpleasant psychological symptoms, but also somatic manifestations, such as pressure surges, extrasystoles, palpitations, etc. That is, Persen and Novopassit relieve only psychological discomfort, and Afobazol additionally eliminates the somatic manifestations of increased anxiety. In addition, Afobazole moderately activates the work of the central nervous system, improving memory and attention, and practically without causing drowsiness. Therefore, Persen and Novopassit can be recommended for use solely for the purpose of calming when a person is tormented by fears, anxiety, tension and other psychological symptoms of nervousness that are not associated with somatic manifestations.

Afobazole is recommended for use in the presence of not only psychological symptoms of increased anxiety, but also somatic manifestations of this condition (sweating, palpitations, extrasystoles, pressure surges, etc.). In addition, Afobazole does not cause drowsiness and moderately activates the central nervous system, so the drug can be taken by people who wish to active image life, drive a car, negotiate constructively and solve complex problems, and not “explode” and get annoyed on various occasions. Persen and Novopassit are not suitable for solving such a problem, since they only reassure, not disposing at all to solving any problems, but introducing a person into a state of conditional “indifference”.

In medicine, there is no concept of "best" or "worst" drugs, so doctors prefer to use the term "optimal". The fact is that for each specific person in a specific situation the best way any one, maximum two drugs will do. It is these drugs, which are the most effective in a particular situation, that are considered optimal. It must be understood that the optimal drugs for each individual person will be different drugs. Moreover, even for the same person in different situations, different drugs may be optimal. Thus, it is simply impossible to calculate 1 - 2 "best" drugs that would be universally suitable for all people with any forms and variants of anxiety. Therefore, for someone, Afobazol will be the best drug, and another person will need a different drug that will become “the best” for him.

Afobazol is a mild anxiolytic that works well for many people in relieving anxiety. However, some note that for them its effect is insufficient, since anxiety is not stopped, and the state is not approaching the desired one. This category of people prefers to use anxiolytics with a stronger anti-anxiety effect, which include the following drugs: Phenibut; Phenazepam (one of the most powerful anxiolytics); diazepam; Lorazepam; Alprazolam.

The above tranquilizers are benzodiazepines and have a pronounced anti-anxiety effect, which, however, is combined with drowsiness, lethargy and depression, which are absent from Afobazol. It is about these powerful tranquilizers that people usually say that they enter into a state of "vegetable" when, along with anxiety, any desire to do anything disappears.

An intermediate position between powerful benzodiazepines and Afobazole in terms of the severity of the anti-anxiety effect is occupied by the following drugs: Chlordiazepoxide; Bromazepam; Gidazepam; Clobazam; Oxazepam. Among the listed drugs, Gidazepam is most often used to relieve anxiety, which many people consider to be the best compared to Afobazol. In addition to these, there are a fairly large number of drugs that have anti-anxiety effects, but it is necessary to find the “best” among them individually.

Afobazole - analogues

There are no drugs that are absolutely identical with Afobazol in terms of action and composition, there are some drugs that have similar properties. However, all these medicines have some differences. Before you start taking them, be sure to consult your doctor.

The most commonly used analogues of Afobazol are as follows:

- Adaptol - this drug belongs to the group of anxiolytic agents. This drug has a tranquilizing effect. During the reception, it quickly relieves the feeling of fear, tension, fatigue, stress.

- Divaza is a drug that is part of the group of tranquilizers. During the reception active ingredient normalizes the blood circulation of the brain, relieves stress, fatigue. It is taken during vegetative disorders, with disorders of the brain that are caused by trauma, ischemic diseases, neurodegenerative diseases and others. And also with increased anxiety, insomnia, headache, neuroinfections.

- Tenoten is a drug belonging to the group of tranquilizers. Quickly relieves anxiety, stress, emotional tension, helps relieve headaches and eliminates sleep problems.

— Persen. This remedy has an antispasmodic and sedative effect. It contains herbal ingredients that help relieve tension, feelings of anxiety and irritation. It can be taken during insomnia, because the drug facilitates the process of falling asleep and does not cause drowsiness.

- Phenazepam is a highly active tranquilizer. The drug has an anxiolytic, anticonvulsant, hypnotic and central muscle relaxant effect on the body. It is used during sleep disorders, neurotic and psychopathic conditions.

Novopassit is a sedative-type sedative that consists of herbal ingredients. The medicine has an effect on the nervous system, relieves nervous tension, fatigue, stress. It also helps with headaches, sleep disorders.

- Grandaxin - the drug belongs to the tranquilizers, which belong to the group of benzodiazepines. Quickly relieves tension, fatigue, excitability, helps with headaches and insomnia. It is also taken in premenstrual syndrome, with myopathy, myasthenia gravis, neuroses, with alcohol withdrawal syndrome and so on.

- Phenibut is a nootropic drug that belongs to tranquilizers. Improves brain activity, increases blood circulation. During the reception, the working capacity of the body increases, mental activity, memory improves, stress, neurosis, tension disappear.

- Mebikar is a drug that belongs to tranquilizers for daytime use. This drug reduces anxiety, tension, fatigue, and also has a mild sedative effect.

Fenzitate is a tranquilizer that belongs to the group of benzodiazepine derivatives. It is used for neurosis, severe fatigue, with emotional stress, vegetative disorders, sleep disorders.

The cheap analogues of Afabozol include the following drugs: Phenazepam, its cost is about 120-140 rubles; Persen, the price is 280-300 rubles; Novopassit, the cost is from 150 to 180 rubles; Mebicar, the price per package is about 280-300 rubles; Fenzitat, the cost of packaging is 140-180 rubles.

The following analogues of Afabozol are dispensed without a prescription: Persen; Novopassit; Phenibut; Tenoten; Phenzitate.

Afobazol's analogs Russian production: Divaza; Tenoten; Phenazepam; Mebicar; Phenzitate.

Reviews of doctors about Afobazole

Smirnova E.A., pharmacy pharmacist

Afobazole is a tranquilizer (anxiolytic). Its action is aimed at relieving anxiety, with neurasthenia and adaptation disorders. The drug perfectly combines both anti-anxiety and activating action. Its advantages include the absence of negative effects on memory and attention, it is not addictive in the patient. Afobazole is not a muscle relaxant. The drug helps well in the fight against irritability, tearfulness, inability to relax, fear and insomnia. In a word, Afobazole helps to cope with the consequences of stressful situations that we often have to face in everyday life. It is important for women to know that this drug should not be taken during pregnancy and during breastfeeding. Persons under 18 years of age, the drug is also contraindicated. The drug is available in tablets, which is a certain convenience for patients, it should be taken after meals. The drug is non-toxic. Afobazole is the most optimal for individuals prone to emotional stress reactions and individuals with increased vulnerability and insecurity.

Kiseleva V.E., pharmacist, pharmacy

Afobazole in tablets is used for increased nervous excitability, anxiety, for the treatment of various types of phobias (fears). The drug does not have a hypnotic effect, so it can be used by drivers behind the wheel. Afobazol only for the treatment of adults.

Uchelkina L.A.pharmacist

Afobazole belongs to the pharmacotherapeutic group - to tranquilizers, does not cause addiction, drowsiness, muscle weakness.

Ionova O. pharmacist

Afobazole reduces anxiety (concern, bad forebodings, fears, irritability), tension (shyness, tearfulness, anxiety, fear). Improvement is observed on the 5-7th day of treatment. The maximum effect is achieved by the end of 4 weeks of treatment. The drug has no muscle relaxant properties, Negative influence on memory and attention. When it is used, drug dependence is not formed and withdrawal syndrome does not develop, which means that it can be prescribed to those people who are related to driving. Maximum daily dose 3 tablets.

Platonov D. G. Psychotherapist, candidate of sciences

No anti-anxiety effect has been found in patients with any level of neurotic anxiety. Pro normal studies I am silent. All positive reviews patients on the drug is undoubtedly due to the placebo effect. Well, like any placebo, it does not give side effects. The drug could make sense if it even claimed fast action(as, for example, adaptol), because possible application limited to situational anxiety manifestations: for example, could be used for fears of public speaking.

Pashyan D. A. Dentist

A certain anti-anxiety effect of this drug is present. It is possible that the effect of this drug is not an effect at all, but a “placebo” effect. As in any other case, it is better to consult a doctor before taking the medicine, you may need a much more effective (prescription) drug.

Komissarov V. B. Manual therapist

"Afobazol" is an inexpensive and effective drug. The price is affordable, sold without a prescription. Very effectively removes the feeling of danger, nervousness, anxiety, insomnia. Normalizes sleep well. I recommend taking it periodically to patients, especially with a combination of anxiety and insomnia. The drug is well tolerated and side effects are rare.

Patient reviews about Afobazole

Katia

Helped not to really go crazy on maternity leave. Still, I'm a mother of twins, and this, I'll tell you, is worse than a hurricane or a tsunami. And if you consider that the husband most spends time at work, and there is no one from relatives to help, then you have to drag everything on yourself. Both household and children. In the end, there comes a point when you just want to lie down in silence, close your eyes and never wake up again. Now I remember these thoughts and am horrified that I could even seriously think about such a thing. 3 months of taking afobazole returned me to a human state, refreshed my brain and patched up my nerves. So now with new forces into battle, as they say. The only warning: these pills are contraindicated for gv.

Svetlana Vasilievna

To date, Afobazole is my favorite drug, I take it in connection with menopause: it relieves arrhythmias, tension, improves sleep, a neurologist recommended it to me. I have a basic disease of DEP (dyscirculatory encephalopathy), this drug suited me. I advise women to take in their transitional period.

Elena B.

And I had a strong allergic reaction, up to Quincke's edema. The first time I drank, I didn’t understand that it was from him, but when I drank a week later, everything happened again, only suprastin didn’t help anymore, I had to dig it out. It’s good that I was at work, our doctors helped me, if it happened on the road, I don’t know what would have turned out. I don’t know, they say, I am the first who has such a reaction to Afobazol.

Victoria D.

She moved with her husband to another city (he was sent there for work). Of course, the city is alien, there are no acquaintances, friends and family, no work either. And we live there for about 5 years. Because of all this, I closed myself in, became very irritable, and I was constantly haunted by incomprehensible fears (that I would never be able to settle down here, find a job, that my husband would leave, that something would happen to my parents without me, because I was not nearby, etc.). I had to somehow cope with all this, I didn’t want to go to psychologists, and I don’t know how to choose them - I stumble upon charlatans. I decided to start with sedatives, the pharmacy advised Afobazol, they say, a good anti-anxiety. I will not say that the effect of it came on the same day of admission. I had to wait, after about a week I felt the effect. Drank 2 months. fears and intrusive thoughts they left and never returned (pah-pah), some kind of confidence appeared, they almost stopped being nervous, got ready, found a job and even managed to make friends. I definitely believe that the drug helped.

Nina G.

I needed sedatives, but what exactly to choose for a long time could not decide. I ventured to try "Afobazol" on the advice of friends. Since I often drive, it was important for me that the tablets do not cause drowsiness and do not slow down the reaction. I guessed with the drug. It was also a big plus that the effect of the tablets persisted after the drug was discontinued for quite a long time.

Marika H.

They took "Afobazol" with a spouse for a couple. Since they have been together for a long time, life has stuck and eternal stress at work, they often quarreled over trifles, always walking around dissatisfied with each other. After 1.5 months of joint reception in our family, the idyll is again. I'm glad I finally found a product that was perfect for me. It doesn't have any side effects. And since I'm constantly behind the wheel, for me it's just salvation.

Stanislav L.

"Afobazol" - quite effective remedy, drank it along with Neurofulol as prescribed by a doctor. Nerves in order led, now calm and happy. Although many write that these two drugs are quite similar in effect, it makes no sense to take them at the same time. And, basically, experts make a choice more in the direction of "Neurofulol", as more effective. But my doctor, apparently, decided to play it safe.

Anna L.

I have been taking it for 3 years, always in courses - it helps a lot to cope with psychos, both at work and in family life. I walk calm as three boas. "Novopassit" helps to calm down well, but all the positive effects are offset by the fact that it constantly makes you want to sleep. With "Afobazole" this is not the case, always cheerful, you can safely drive. But at night I sleep like the dead.

Polina E.

I never recommend anything I haven't tried myself. So, afobazole has been personally tested and verified by me, so I can recommend it to those who are experiencing stress or a similar nervous and emotional state. I always argue when they say that it does not instantly help. It's even better, I'm always suspicious of drugs that promise help the very next day. That doesn't happen. So in the case of afobazole: it is a comprehensive, serious approach that is good.

Alena M.

Not the first year I have been taking the drug, in my opinion, one of the best anti-anxiety drugs. With any valerian, of course, it’s not even close. It is strange to read such comparisons. Didn't they ever pass difficult exams with valerian in their youth? I gave up and I don't want a repeat of that experience. It's good that there is modern drugs, which soothe and do not throw you into sleep.

Marina M.

In a certain situation, "Afobazol" turned out to be exactly the drug that coped and helped to get through difficulties. At that time, I took it for the first time and did not know what to expect, I only knew that I should drink the course and wait for the effect not immediately, but after a couple of weeks. So everything turned out. I managed to get my bad emotions under control.

Daria R.

I work in the service industry, so I deal directly with customers. And there are a lot of people who are dissatisfied. At the same time, I need to keep the brand, always remain, let's say, in an emotional form. That is why sometimes you have to resort to the help of afobazole. I like it, its lasting effect - I will drink a course, then I am calm for several months.

Alina A.

The drug is completely ineffective. It has very little active ingredient, so it does not have the desired effect. Well suited for people who like to take pills, for suspicious people, because it does not cause adverse reactions, and even cause poisoning at high doses is not capable. Placebo effect on the face. Well, for people who are under stress, it is also not effective, a waste of money and not small.

Alena A.

The first time I needed a sedative was when my mother became seriously ill. Anyone who cared for a bedridden relative will understand me. On the advice of a doctor, I purchased Afobazol. This drug does not help many at all, but it worked very well and quickly for me. Maybe because I have never taken sedatives before, or maybe I myself am very thick-skinned, but nervousness and irritability disappeared the very next day after I started taking it. I am very pleased that there is no drowsiness and lethargy, and there are no problems with drug withdrawal. Now "Afobazol" is my lifesaver in stressful situations.

Tatyana V.

Honestly, for me the drug was useless. Received it as directed family doctor in complex treatment erosive gastritis. The state at that time was irritable, anxious, and the doctor suggested that this could negatively affect the outcome of treatment. I took it for about a month, they say it has a cumulative effect and you can increase the intake up to 3 months. After the first month, having not seen the effect, I stopped taking it, because I thought that if the drug was effective for me, I could observe certain changes after this period. Maybe it wasn't the right fit for me because I've heard good reviews about it.

Liana K.

The time is now such that I would recommend afobazole to many, obviously it would not be superfluous to drink it to people in the subway and at work. Why do I calmly perceive them all, because I accept it. Otherwise, it would have broken long ago. And with him, even such a thought does not arise: why make a fuss when you can be calm and control emotions.

Catherine K.

At my girlfriend special child, very hard, of course, with him. Although she loves him madly, I see how she suffers, cries, gets angry. You give him a spoonful of porridge, and he laughs on her head and laughs ... So, according to her, afobazole helps her not to become limp in this situation.

Andrew F.

I like that it is not addictive, you can jump off at any time if you feel that you have had enough. Before that, I drank valerian in tablets, slept normally with it, but without it, insomnia immediately began.

Maria P.

Mom works as a teacher, the senior classes bring her terribly. He says that after two weeks of drinking afobazole, he does not perceive it so painfully and somehow manages to cope with them. It's not great, of course, that you have to drink sedatives for this. Well, what to do, age and specialty are not at all the ones to change jobs.

Sergei V.

"Afobazol" helped me get rid of sleep problems. I had a period of shift work at night in my life, and the regime went to hell. It turns out that this has a very strong effect on well-being and, in general, on adequacy. After that, I could not fall asleep at midnight, and only after a week of taking Afobazol did my sleep return to normal.

Elena K.

I tried everything to make my husband quit smoking, and finally, with Afobazol, the two of us managed to achieve a result! Prior to this, my husband became so irritable that I myself could not stand it and bought him a new pack, and then weaning went smoothly.

Larissa M.

I have to sit next to a terrible colleague, he brings me up every day, and while the project is in full swing, there is no way to change the situation. Afobazol helped me grow Zen and treat his sexist antics with healthy indifference.

Anna P.

They suddenly began to creep up on me, suddenly a wild fear begins from somewhere, most often it happened in a dream, I wake up abruptly in wild horror with cold sweat on my forehead and sweaty palms. I did not dare to go to the doctor, I was afraid that they might force me to register with a psychiatrist. In the nearest pharmacy, the pharmacist advised me such pills. To be honest, the price bites. But I bought. I took the inner liner (instructions) for two weeks. And they really made an impact on me. The nightmare that had been haunting me for several months had let go. There are quite a lot of tablets in a pack, 60 pcs. I only drank half, so I decided to stop my treatment for now. If suddenly the attacks resume on a new one, I will continue the treatment and finish the course to the end.

I liked this drug, after taking it for a week, my anxiety decreased, my mood improved significantly, as if I got out of the hole. Even if it was a placebo effect, I am more than satisfied with it.

Ekaterina Sh.

Honestly, I do not understand the general admiration for this drug. The therapist prescribed me "Afobazol" when I was just starting neurotic disorder, as a remedy for panic attacks, anxiety, fear and growing. I remember that the price this drug not small, but bought, in the hope that it will help. From personal experience, I can say that there was not much effect. All problems remained relevant, anxiety did not decrease, panic attacks did not pass though acute situation, at that time was not yet. Maybe it needs to be taken longer, I don't know. Personally, "Afobazol" did not help me.

Yana V.

I took Afobazol for a month on the recommendation of my neurologist. In my situation, the drug worked perfectly. Was lingering against the backdrop of death loved one. As far as I understand, the drug does not help with acute problems. Works well in cases where a person does not need strong drugs and only minor adjustments are required. There were no side effects at all and addiction too.

Elena P.

Good afternoon! After the birth of the child, there were problems with the nerves. She became irritable, tearful, constantly lashed out at her husband, there were even tantrums. I tried many sedatives, but to no avail. The pharmacy advised me to buy Afobazol. Although the drug is not cheap, I decided to try it. I will say right away that there will be no instant relief. I took 2 tablets per day. The mood became more positive after about 2 weeks of taking it, I became more tolerant and calmer. I liked the fact that there is no sedative effect. In general, the drug suited me.

Alenka S.

The doctor prescribed "Afobazole" to calm the nerves and reduce the temperature. Regarding the first - there were no changes. I am quick-tempered, emotional. But "Afobazl" does not relieve these symptoms. I had neurocirculatory dystonia (who knows - the symptoms are terrible), which arose due to stress. Then cheap Alora pills helped me. "Afobazol" is more expensive, but does not give such a result. "Afobazol" was prescribed to me when the temperature was 37.7 (it lasted more than a month). Then the psychotherapist suggested that this was a violation of the thermocenter. Here "Afobazol" coped with the problem.

Julia N.

Before the flight, my mother was advised to drink Afobazol, as she is very afraid of flying, because she was in a situation where the plane committed emergency landing. She drank in the evening and we didn't know what to do with her! Some creatures seemed to her, fears escalated, and instead of a sedative, we observed an absolutely opposite effect. They barely calmed her down before the plane and gave her sleeping pills. So in our case, this medicine played a cruel joke.

Katya M.

Honestly, not my medicine. Of course, sedative effect present, but according to my personal feelings, the same as the usual valerian in tablets. But the plus is that it is not as addictive as valerian, I drank the course and no longer want to. I did not find any side effects, although I have more than one chronic disease. Yes, it still does not interfere with concentration, and I also did not notice drowsiness.

Milan S.

At the moment it is one of the best drugs capable of bringing the human nervous system into a balanced state. My husband regularly takes afobazole due to constant stressful situations at work. The drug is absolutely harmless, and most importantly, does not cause drowsiness, which is very important when driving. Even with long-term use there is no addiction to the drug and there are no side effects.

Olga K.

Since my work is very stressful, my head always hurt before, and I felt disgusting. She was nervous and squeezed like a lemon. After consulting with my doctor, they discovered that I had mental overwork and prescribed me to take Afobazol. The medicine is really good. In any case, it helped me. And now in extreme situations and for prevention mental disorder I always accept only Afobazol. The price is certainly high, but the drug helps me, that's why I buy it.

Inessa K.

For the first time, the desire to drink a sedative arose when, sitting at home all day with a child, I felt that I was going crazy, everything was heating me up (mommies would understand me, endless lack of sleep, monotony). But I was skeptical about such drugs. A good friend - a pharmacist suggested trying Afobazole, because he trusts him. I bought it ... I took it only as indicated in the instructions, after a couple of weeks I realized (I took it for a month in total) that everything was fine, I stopped breaking down on my household, the problems became trifles, because everything is solvable. And my mood improved!

Tatyana S.

Afobazol was prescribed to me by a doctor when I got into a difficult everyday situation and my nerves were at the limit. I was a little afraid to take these pills for fear of addiction, but since my state of mind left much to be desired, I constantly cried, I had no other choice. What can I say? I liked the tablets. I drank them for 2 months, during which time I became calmer, I had a feeling that after using Afobazol I began to look at everything as if through a bus window, a little detached or something, while there was no drowsiness or addiction, I just stopped taking as needed and all.

Helga B.

A good anti-anxiety drug, it relieves excessive tension well and increases stress resistance in the rhythm of a tense labor activity. It does not cause drowsiness and incoordination, which allows you to drive a car while taking it. I am very pleased that the drug is not addictive.

Storage conditions and shelf life

Store below 25°C.

Keep out of the reach of children.

The shelf life of the drug Afobazole is 3 years.

Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies: Without a prescription.

We want to emphasize that the above description of the anti-anxiety drug Afobazol performs an exclusively exploratory function! More precise guidance on the use of the proposed tranquilizer can be obtained by studying the instructions officially approved by the manufacturer. Remember - self-medication is irresponsible and unsafe for health! We strongly recommend that you consult a doctor before starting therapy with Afobazol.

Afobazole is an anxiolytic agent (tranquilizer). Restores psychological well-being, improves the state of various somatic, vegetative and cognitive disorders.

Eliminates muscular, sensory, cardiovascular, respiratory, gastrointestinal symptoms in somatic disorders. Reduces the frequency of manifestation of vegetative disorders, including dry mouth, sweating, dizziness. Increases the ability to concentrate, improves memory.

In this article, we will consider why doctors prescribe Afobazol, including instructions for use, analogues and prices for this drug in pharmacies. REAL REVIEWS people who have already used Afobazol can be read in the comments.

Composition and form of release

Clinico-pharmacological group: tranquilizer (anxiolytic). The composition of Afobazole includes 5 or 10 mg of the substance Afobazole as an active ingredient and auxiliary components:

• potato starch (Amylum solani);
• microcrystalline cellulose (Cellulose microcrystalline);
• milk sugar (Saccharum lactis);
• povidone (Povidonum);
• magnesium stearate (Magnesium stearate).

Afobazole is available in tablet form. Tablets are flat, cylindrical, chamfered, packed in 10 or 25 pieces in blisters. Their color can vary from white to white with a creamy tint.

What is Afobazole used for?

The Afobazol instructions list the cases when it is recommended to take it, these are:

• as a means of facilitating the process of cessation of nicotine;
• dermatological diseases;
• oncological diseases;
• anxiety states caused by neurasthenia and other adaptive disorders;
• somatic diseases (irritable bowel syndrome, systemic lupus erythematosus, hypertension, arrhythmia, bronchial asthma, coronary heart disease);
• sleep disturbances, neurocircular dystonia ("heart neurosis"), PMS (premenstrual syndrome).

Instructions for use positions afobazole as a course preparation. That is, all the above effects occur only with the regular use of tablets. The maximum effect of afobazole is observed on the 5-7th day of admission and persists for 7-14 days after the end of the course.

pharmachologic effect

Afobazole, due to its active ingredient, has an effective anxiolytic effect and a hypnosedative effect. The drug does not have negative impact to the level of concentration of attention or memory.

At long-term use drug dependence does not develop, due to which the withdrawal syndrome is completely absent. Afobazole reduces the psychological discomfort that occurs during the development anxiety states(bad foreboding, insomnia, anxiety, irritability), as well as the consequences of nervous strain (tearfulness, causeless fear, fearfulness, inability to relax and restlessness).

The drug improves mental condition body with a variety of cognitive, somatic or vegetative disorders.

How effective is Afobazole?

It must be understood that the drug belongs to the group of "soft" tranquilizers and for serious disorders of the nervous system, such as real depression, in contrast to transient depressive states, it is unlikely to help. Afobazole is a drug mainly for people with a healthy nervous system who are going through some difficult periods in life and stress - exams, a change of scenery, difficulties in the family, somatic disease, etc.

In such cases, taking the medicine is much more rational than taking "heavy" drugs that have many side effects. In addition, despite the fact that the drug is sold without a prescription, it is highly undesirable to treat it without consulting a doctor. Only a specialist will be able to individually understand the problem and say which remedy is best suited in a particular case. This method allows you to avoid wasted money and start the healing process earlier.

Instructions for use

According to the instructions for use, Afobazole is prescribed immediately in full therapeutic dose(for example, many tranquilizers require a gradual increase in dose). You can also abruptly stop taking Afobazole without fear of the development of a withdrawal syndrome, while most anxiolytics should be discontinued gradually, reducing the dose.

• Afobazol tablets are taken orally, after meals, whole, washed down plain water. The dose for a single dose is 10 mg, the daily dose should not exceed 30 mg, in severe cases the dose is increased to 60 mg / day. The drug is taken 3 times / day.

The duration of therapy is 2-4 weeks, in severe cases - up to 3 months. A second course can be prescribed only after a month break.

Contraindications

You can not use the drug in such cases:

1. Hypersensitivity to Afobazole or its components;
2. Use in pregnant women;
3. Use in nursing mothers;
4. Individual intolerance to Afobazole or its components.
5. Use in patients under 18 years of age /

Side effects

Taking Afobazole sometimes leads to side effects such as:

• work disorders gastrointestinal tract: vomiting, diarrhea, nausea;
• allergic reactions: rash, redness, urticaria, itching on the skin.

Overdose

With a significant overdose and intoxication, the development of a sedative effect and increased sleepiness without signs of muscle relaxation. As an emergency, caffeine 20% solution is used in ampoules of 1.0 ml 2-3 times a day subcutaneously.

Afobazole and alcohol

Afobazole does not enhance the narcotic effect of alcohol, therefore, when taking Afobazole with alcohol, the drug will not cause poisoning. But taking alcohol during treatment is still not worth it, since you can reduce or nullify the effect of treatment with Afobazol.

• The principle of action of alcohol and Afobazole on the central nervous system is different, so taking alcohol and Afobazole at the same time can reduce or completely remove positive effect from taking Afobazole. This is due to the fact that alcohol inhibits the functioning of the nervous system, while Afobazole, on the contrary, activates it.

The combination of alcohol and Afobazole in the treatment hormonal disorders in women also will not lead to a positive result.

Analogues

Like most other popular drugs, Afobazole has analogues, that is, drugs that are similar to it in their own way. pharmacological action but differ in composition.

• Analogues of the drug are: homeopathic remedy Tenoten, Grandaxin, Stresam, Mebicar IC, Adaptol, Tranquilar IC.

The price of Afobazole analogs varies depending on the pharmacy and the manufacturer. Adaptol, for example, is somewhat cheaper than Afobazole, but at the same time it is just as effective, characterized by low toxicity, does not cause drowsiness, addiction and withdrawal syndrome.

Prices

The average price of AFOBAZOL in pharmacies (Moscow) is 346 rubles.

Storage conditions

The drug should be stored in a dark, dry place at an air temperature not exceeding 25 degrees. Shelf life is 2 years, after which the product can not be used.

Terms of dispensing from pharmacies

Without recipe.

1. Margo

   I used to drink different herbs, but they either make you want to sleep or you don’t feel any effect at all. And I need a clear mind to work. At some point, I tried afobazole - there was another nerve at work (I work as a producer and always have to shake for everyone).

   It clears the mind well and periodically (two or three times a year) I repeat the course during deadlines. You stop being an emotional monster and run to cry in the toilet because of a deadline failure))

2. Maria

   My story is banal and as old as the world. At first she was killed at the university to get a red diploma. Constant lack of sleep, cramming, exam stress and more. Then, almost without interruption, a responsible position in a large international law firm. And here everything is the same - stress, lack of sleep. I had to exhaust myself in order to complete and complete all the tasks. To be fair, I have to say that I'm not the only one. Working in large companies is stressful for everyone. On the advice of a more progressive colleague, I bought afobazole at a pharmacy.

   According to her laudatory reviews, it was clear that the medicine helps to calmly experience stress. After drinking the first course of these pills (3 months), I really felt that it became easier to endure workloads, I stopped “killing myself” if I couldn’t do something on the first try. And in general, I can state that the general moral, and then physical state mine has improved.