Aspirin with effervescent. Instructions and recommendations for the use of aspirin effervescent tablets

Surely each of us at least once in our lives took the drug "Aspirin C". If you do not know what it is for, then we will tell you about it in the presented article. In addition, we will tell you about side effects and has contraindications this drug how it should be taken and in what quantity.

Release form of the drug, composition

In what form does Aspirin C go on sale? This medication can be found in pharmacies in the form effervescent tablets. They contain acetylsalicylic and ascorbic acid. This drug is sold in blisters, which are packed in a cardboard box.

Pharmacological characteristics

When do doctors prescribe Aspirin C (effervescent tablets) to their patients? Instruction this tool contains full information on this account. According to her, the presented medication is a non-steroidal anti-inflammatory drug, as well as non-narcotic analgesic and antiplatelet drugs.

Due to its composition, the mentioned medication is able to have anti-inflammatory, analgesic and antipyretic effects. In addition, it significantly reduces platelet aggregation.

The principle of action of the drug

How does the drug "Aspirin C" work? Instructions for use states that the main mechanism of action of it active component(that is, acetylsalicylic acid) is the inactivation (irreversible) of the cyclooxygenase enzyme, which contributes to the disruption of the synthesis of prostacyclins, prostaglandins and thromboxane.

By the way, it is precisely due to a decrease in the production of prostaglandins that their pyrogenic effect on the centers of thermoregulation and the sensitizing effect on sensitive nerve endings. As a result, this leads to the elimination of pain syndromes.

It should also be noted that acetylsalicylic acid is also capable of blocking endothelial cell cyclooxygenases, where prostacyclin, which has antiplatelet activity, is synthesized. However, one cannot help saying that the cyclooxygenase complex of endothelial cells is less sensitive to the effects of acetylsalicylic acid. Therefore, unlike platelets, this blockage is reversible.

Properties of the medicinal product

Now you know exactly how the drug "Aspirin C" works. Instructions for use of this medication states that, in addition to acetylsalicylic acid, it contains and a large number of vitamin C. This component makes the drug immunostimulating. Due to the presence of ascorbic acid, the drug is able to increase resistance human body and reduce vascular permeability.

It should also be noted that the composition of effervescent tablets also includes a substance such as sodium bicarbonate. Its presence neutralizes free hydrochloric acid in the main digestive organ up to pH 6.0-7.0. Due to this, the irritating effect of acetylsalicylic acid on the mucous membranes of the digestive tract is noticeably reduced.

Indications for the use of the medicinal product

At what deviations is the drug "Aspirin C" (effervescent tablets) prescribed? The instruction attached to this drug contains a list of the following indications:

• prevention (secondary) myocardial infarction;
• relief of a migraine attack (acute);
• rheumatic diseases;
• prevention of myocardial infarction in patients with unstable angina;
• treatment and prevention of ischemic transient disorders cerebral circulation;
• pain syndromes of medium and low intensity of various origins (including inflammatory);
• prevention of embolism and thrombosis;
• fever in infectious and inflammatory diseases.

Contraindications to the use of a medicinal product

In what cases can not use the drug "Aspirin C"? Instructions for using this medicinal product contains a list of the following contraindications:

It should also be noted that the drug "Aspirin C" should not be taken by children under 15 years of age who have acute respiratory diseases caused by viral infections. Otherwise, there is big risk development of Reye's syndrome (that is, acute fatty degeneration and liver encephalopathy with the development liver failure).

Take with extreme caution!

The drug "Aspirin C" is prescribed with extreme caution for gout and hyperuricemia, as well as for patients who have ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, impaired liver and kidney function, bronchial asthma, chronic diseases respiratory organs, hay fever and polyposis of the nasal mucosa.

It should also be noted that the drug should be taken under the strict supervision of a physician in case of allergic reactions to medical supplies(including NSAIDs) and in the 2nd trimester of pregnancy.

Instructions for taking the medication

How should you take the drug "Aspirin C", the composition of which was presented above? This medication is intended for oral administration. For the relief of pain (including those of inflammatory origin), as well as in febrile conditions, a single dosage for adults should be 1-2 tablets. In this case, the daily volume should not exceed eight pieces.

For children over four years of age, single dose for them is 0.5-1 tablets, and daily - 1-4 pieces.

If necessary, a single dose of the drug can be taken three times a day with an interval of 5-8 hours.

In patients with comorbidities work of the kidneys or liver, the dose should be less, and the interval between doses increased.

It should also be noted that before taking effervescent tablets must be dissolved in ordinary water(in ½ cup). It is advisable to do this immediately before using the product.

Side effects

Now you know how to take the drug "Aspirin C". Reviews about him are exclusively positive character. However, it should be noted that this drug can cause many side effects. As a rule, they manifest themselves in the form of nausea, anorexia and epigastric pain. AT rare cases(especially with frequent and long-term use of the drug), patients experience ulcerative erosive lesions of the gastrointestinal tract, signs of intestinal bleeding (tarry stools are observed), as well as hidden blood loss from the gastrointestinal tract.

On the part of the hematopoietic system, patients may develop thrombocytopenia and anemia (due to hidden bleeding from the digestive tract).

Also, patients rarely experience allergic reactions in the form of bronchospasm and skin rash. As a rule, such side effects occur in patients with bronchial asthma.

Special instructions for the use of the drug

A large number of people take the drug "Aspirin" with a hangover. And there is nothing surprising in this. After all, it eliminates headaches very quickly.

It should be especially noted that for adolescents and children with diseases that are accompanied by hyperthermia, it is better to prescribe this drug only if other medicines are not effective.

If, after applying the above medicinal product the patient had incessant vomiting, this indicates the development of Reye's syndrome.

In people with allergic diseases, including bronchial asthma, hay and allergic rhinitis, skin itching, urticaria, swelling of the nasal mucosa, chronic infections respiratory organs, as well as in patients with hypersensitivity to antirheumatic drugs and analgesics, severe attacks bronchial asthma.

It is impossible not to mention that during the period of application of the presented remedy, one should refrain from drinking alcoholic beverages.

The drug "Aspirin C": analogues of the drug

The pharmaceutical market has great amount analogues of the drug "Aspirin C". The most common among them are the following medicines: "Acetylsalicylic acid", "Nextrim Fast", "Atsbirin", "Taspir", "Fluspirin", "Upsarin Upsa" and so on.

With analgesic property. Available in effervescent tablets, soluble in water. The agent is able to have an inhibitory effect on platelet aggregation. "Acetylsalicylic acid" (aspirin) contains ascorbic acid, which stimulates the redox processes of carbohydrate metabolism. In addition, the drug reduces blood clotting, promotes tissue regeneration, and increases the body's resistance.

Indications for the use of the drug "Aspirin C"

The main indications for the use of the drug are:

• Mild to moderate pain syndromes various etiologies (toothache, headache, neuralgia, muscular and menstrual pains).
• Infectious and inflammatory diseases, accompanied by an increase in body temperature.

"Aspirin". Description of the dosage regimen

In the event of mild to moderate pain, as well as febrile conditions, a single dose is one or two effervescent tablets. Maximum dose in one dose - two tablets. During the day, it is recommended to take no more than 6 tablets with an interval of at least 4 hours. The drug should not be taken alone without medical supervision for more than 7 days, as analgesic and no more than 3 days as an antipyretic.

Side effects

Taking Aspirin C may cause side effects: nausea, vomiting, stomach pain, erosive and ulcerative lesions of the gastrointestinal tract, liver dysfunction, tinnitus, dizziness, hemorrhagic symptom, thrombocytopenia, stone formation, kidney dysfunction, skin rash, bronchospasm.

Contraindications to taking the drug "Aspirin C"

• Exacerbation of erosive and ulcerative lesions of the gastrointestinal tract, bleeding;
• Asthmatic manifestations caused by the intake of salicylates;
• Severe violations the work of the liver and kidneys;
• Hemophilia;
• Hemorrhagic diathesis;
• Thrombocytopenia;
• Pregnancy (first and third trimesters);
• Breast-feeding;
• Age up to 15 years;
• Special sensitivity to aspirin.

Particular caution is required in the use of the drug when simultaneous treatment anticoagulants. reduces excretion, which causes an attack of gout.

Long-term use of the drug "Aspirin C" requires blood and feces tests, monitoring of liver function. Acetylsalicylic acid slows down the process of blood clotting. Patients who are prescribed abdominal operation, it is necessary to warn the doctor about taking the medicine. During the period of treatment with the drug, you should stop taking ethanol in order to avoid provoking

In case of an overdose of Aspirin, negative manifestations in the form of dizziness, excitation of the central nervous system, severe headache, hearing loss and vision loss, nausea, vomiting. In addition, in case of an overdose, convulsions, depression of consciousness, coma, drowsiness, difficulty breathing, and a violation of metabolic processes in the body are observed. elimination adverse symptoms required to be carried out in medical institution under the supervision of a physician. With signs of poisoning, gastric lavage is done, "Activated charcoal", laxatives are prescribed.

Interaction with other drugs

"Aspirin C" helps to increase the toxicity of methotrexate, analgesics containing opium, oral hypoglycemic drugs, indirect anticoagulants, heparin, reserpine, sulfonamides, thrombolytics. The drug reduces the effect of uricosuric diuretics. Increases the concentration of digoxin, barbiturates. promotes the absorption of iron-containing drugs.

(500 mg); excipients: sodium carbonate anhydrous, lemon acid anhydrous, sodium citrate anhydrous, sodium bicarbonate, crospovidone, aspartame, natural orange flavor, povidone.

With vitamin C: acetylsalicylic acid(330 mg), ascorbic acid (200 mg). Excipients: glycine, sodium benzoate, anhydrous citric acid, monosodium carbonate, polyvinylpyrrolidone.

Package

4 effervescent tablets in an aluminum foil strip coated with inside polyethylene. 4 or 25 strips with instructions for use in a carton pack.

With vitamin C: 10 tablets in a tube. One or two tubes in a carton

Manufacturer

UPSA Laboratories (France).

Pharmacological group

Non-narcotic analgesics / antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid derivatives + vitamin.

pharmachologic effect

It has anti-inflammatory, analgesic and antipyretic effects associated with the suppression of cyclooxygenase 1 and 2, which regulate the synthesis of prostaglandins. Reduces aggregation, platelet adhesion and thrombus formation by suppressing the synthesis of thromboxane A2 in platelets, while the antiplatelet effect persists for a week after a single dose.

advantage soluble form drug in comparison with the traditional is more complete and rapid absorption of the active substance and its better tolerability.

Pharmacokinetics

Aspirin UPSA is absorbed faster than regular aspirin. The maximum concentration of acetylsalicylic acid is reached in 20 minutes. The plasma half-life is 15 to 30 minutes. Acetylsalicylic acid undergoes hydrolysis in plasma to form salicylic acid. Salicylate is largely associated with plasma proteins. Urinary excretion increases with urine pH. The half-life of salicylic acid is from 3 to 9 hours and increases with the dose taken.

Indications

• Moderate or mild pain syndrome in adults of various origins: headache (including alcohol-related withdrawal syndrome), toothache, migraine, neuralgia, chest radicular syndrome, muscle and joint pain pain during menstruation.
• Increased body temperature with colds and other infectious and inflammatory diseases (in adults and children over 15 years old).

Contraindications

• Erosive and ulcerative lesions gastrointestinal tract in the acute phase, gastrointestinal bleeding;
• portal hypertension;
• "Aspirin" asthma;
• Dissecting aortic aneurysm;
• Phenylketonuria;
• Hemorrhagic diathesis, including hemophilia, telangiectasia, von Willebrand disease, thrombocytopenia, hypoprothrombinemia, thrombocytopenic purpura;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Hypersensitivity to the components of Aspirin UPSA or other non-steroidal anti-inflammatory drugs;
• Severe violations of the liver and kidneys;
• Vitamin K deficiency.

The drug is allowed to be taken only in the II trimester of pregnancy, when taken during lactation breast-feeding it is recommended to stop. Aspirin UPSA is not used in children under 15 years of age due to the risk of developing Reye's syndrome.

carefully with urate nephrolithiasis, hyperuricemia, decompensated heart failure and peptic ulcer stomach and duodenum in history. When using aspirin, be aware that it can cause acute attack gout with existing predisposition.

Dosage and administration

The dosage and schedule of admission is determined by the attending physician, since everything here depends on the age and condition of the patient.

Effervescent tablets must first be dissolved in 100-200 mg boiled water room temperature. The drug is preferably taken after meals.

At severe pain you can take 400-800 mg of acetylsalicylic acid 2-3 times a day (but not more than 6 g per day). As an antiplatelet agent, small doses are used - 50, 75, 100, 300 or 325 mg of the active substance. With fever, it is recommended to take 0.5-1 g of acetylsalicylic acid per day (if necessary, the dose can be increased to 3 g).

The duration of treatment should not exceed 14 days.

Side effect

• Skin rash, "aspirin triad", bronchospasm and Quincke's edema;
• Impaired kidney function;
• Epistaxis, increased blood clotting time, bleeding gums;
• Nausea, loss of appetite, vomiting, gastrointestinal bleeding, pain in epigastric region, diarrhea;
• Thrombocytopenia, leukopenia, anemia, hyperbilirubinemia.

When unwanted effects Aspirin UPSA should be discontinued.

Overdose

Intoxication should be feared in the elderly and especially in children younger age(medical overdose or accidental intoxication, common in very young children), which can be fatal.

Clinical symptoms- with moderate intoxication, tinnitus is possible, hearing loss, headaches, dizziness, nausea are a sign of an overdose. These phenomena are eliminated by lowering the dose. In severe intoxication - hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiovascular collapse, respiratory failure, high hypoglycemia.

Treatment — quick removal drug by gastric lavage. immediate hospitalization in a specialized institution. Control acid-base balance. Forced alkaline diuresis, hemodialysis or peritoneal dialysis if necessary.

drug interaction

Combinations with methotrexate are contraindicated, especially at high doses (this increases toxicity); with oral anticoagulants at high doses, the risk of bleeding increases.

Undesirable combinations - with oral anticoagulants (at low doses, the risk of bleeding increases), with ticlopidine (the risk of bleeding increases), with uricosuric agents (a decrease in the uricosuric effect is possible), with other anti-inflammatory drugs.

Combinations requiring precautions: with antidiabetic agents (in particular, hypoglycemic sulfonamides) - the hypoglycemic effect increases; with antacids - you should observe the intervals between taking antacids and salicylic drugs (2 hours); with diuretics - at high doses of salicylic drugs, it is necessary to maintain an adequate supply of water, monitor kidney function at the beginning of treatment due to possible acute kidney failure in a dehydrated patient; with corticoids (glucocorticoids) - there may be a decrease in salicylaemia during treatment with corticoids and there is a risk of overdose of salicyl after its termination.

Pregnancy and lactation

The drug is contraindicated in pregnancy in the I and III trimester. In the second trimester of pregnancy, a single dose of the drug at recommended doses is possible only if the expected benefit to the mother exceeds potential risk for the fetus. If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

special instructions

The drug can promote bleeding, as well as increase the duration of menstruation. Aspirin increases the risk of bleeding in case of surgical intervention.

In children, when prescribing the drug, age and body weight must be taken into account.

With a sodium-free diet when compiling daily diet Keep in mind that each tablet of Aspirin UPSA with Vitamin C contains approximately 485 mg of sodium.

In animals, the teratogenic effect of the drug is noted.

Storage conditions

In a dry place, out of reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

Pharmachologic effect:
Combined product. Acetylsalicylic acid has an analgesic (pain reliever), antipyretic, large doses ah - anti-inflammatory action. It has antiaggregant (preventing the formation of a blood clot) activity. Vitamin C contained in the product replenishes the body's need for ascorbic acid.
The main mechanism of action of acetylsalicylic acid is the irreversible inactivation (suppression of activity) of the cyclooxygenase enzyme (an enzyme involved in the synthesis of prostaglandins in the body), as a result of which the synthesis of prostaglandins is disrupted. (Prostaglandins - biologically active substances produced in the body. Their role in the body is extremely multifaceted, in particular, they are responsible for the appearance of pain and swelling at the site of inflammation).
The addition of vitamin C increases the body's resistance, reduces vascular permeability.

Aspirin with method of administration and dose:
The drug is prescribed inside. For the treatment of pain syndrome, febrile conditions one-time dose of aspirin-C for adults is 1-2 tablets; daily - up to 8 tablets. For babies over 4 years old, a single dose is 0.5-1 tablet; daily - 1-4 tablets. A single dose, if necessary, can be taken 3-4 times a day with an interval of 4-8 hours.
The soluble form of aspirin C is Aspirin Upsa. The tablet is dissolved in a glass of water. Adults as an analgesic and antipyretic are prescribed 0.25-1 g 3-4 times a day. The maximum daily dose is 4 g (up to 12 tablets). As an anti-inflammatory agent - 0.5-2 g 3-4 times a day. The maximum daily dose is 6 g (up to 18 tablets).
In children, the usual dose is 25 to 50 mg/kg per day, given in 4 to 5 doses at least 4 hours apart. The maximum daily dose is 100 mg/kg per day. At the age of 10 to 15 years (with a baby weighing from 30 to 50 kg), a single dose is 375-625 mg (1-2 tablets); daily dose - 1500-2500 mg (4.5-7.5 tablets). At the age of 4 to 10 years (with a baby weighing from 16 to 30 kg), a single dose is 200-375 mg (0.5-1 tablet); daily dose -800-1500 mg (2-4.5 tablets).
For children and adolescents (under 14 years of age) with diseases accompanied by hyperthermia (increased body temperature), it is advisable to prescribe aspirin-C only if other substances are ineffective.
For the prevention and treatment of cerebral circulation disorders, the dose of the product is 0.125-0.3 g per day. At unstable angina and for secondary prevention myocardial infarction, the average daily dose of acetylsalicylic acid is 0.3-0.325 mg. The daily dose of the product is recommended to be divided into 3 doses.
In patients with concomitant impaired liver or kidney function, it is necessary to reduce the dose or increase the interval between doses.
When taking the tablet, dissolve in water and drink.

Aspirin with contraindications:
Not to be used in pathological bleeding tendencies. It is undesirable to use the product with simultaneous therapy with anticoagulants (for example, coumarin derivatives, heparin), with a lack of glucose-6-phosphate dehydrogenase; with asthma, hypersensitivity to salicylates and other anti-inflammatory and antirheumatic drugs or other allergens; with chronic or recurrent diseases of the stomach and duodenum, with impaired renal function; during pregnancy, especially
in the later trimester.
During breastfeeding, when taking aspirin-C at normal doses, interruption of breastfeeding is usually not required. With regular intake of large doses of the product, it is necessary to resolve the issue of stopping breastfeeding.
Without medical supervision, the product should only be taken in normal doses and only for a few days.
In case of overdose with mild intoxication(poisoning) possible nausea, vomiting, pain in the epigastrium (the area of ​​the abdomen located directly under the convergence of the costal arches and the sternum), also (especially in infants and elderly patients) tinnitus, dizziness, headaches, decreased vision and hearing. With a significant overdose, incoherent thinking, confusion, drowsiness, collapse appear ( sharp drop blood pressure), tremor (trembling of the limbs), shortness of breath, suffocation, dehydration, hyperthermia ( heat body), coma (unconsciousness), alkaline reaction urine, metabolic acidosis (acidification in metabolic disorders), respiratory (gas) alkalosis (slagging), carbohydrate metabolism disorders.
The lethal (capable of death) dose of acetylsalicylic acid for adults is more than 10 g, for babies - more than 3 g.

Aspirin with side effects:
In patients suffering from allergic diseases, including bronchial asthma, allergic and hay rhinitis (runny nose), urticaria, skin itching, swelling of the mucous membrane and nasal polyps, also in combination with chronic infections respiratory tract, in patients with increased susceptibility to analgesic and antirheumatic products of any type, it is possible to develop "aspirin" asthma (acute asthma attacks caused by taking acetylsalicylic acid).
In rare cases, hyperergic reactions (eg, skin, shortness of breath); in very rare cases - complaints from the gastrointestinal tract, gastrointestinal bleeding, thrombocytopenia.

Release form:
Soluble tablets containing acetylsalicylic acid 0.4 g and ascorbic acid (vit. C) 0.24 g, in a pack of 10 pcs. Effervescent tablets containing acetylsalicylic acid 0.33 g and ascorbic acid (vit. C) 0*2 g, pack of 10 pcs.

Synonyms:
Ask-S, Aspirin Upsa, Aspro-S, Plidol-S, Solucetil, Fortalgin S.

Storage conditions:
List B. In a dry place.

Attention!
Before using the medication "Aspirin with" you need to consult a doctor.
The instructions are provided solely for familiarization with " Aspirin with».

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

Active substance:

Dosage form:

Compound:

1 tablet contains

Active ingredients: acetylsalicylic acid 400 mg, ascorbic acid (vitamin C) 240 mg.

Excipients: sodium citrate dihydrate 1206 mg, sodium bicarbonate 914 mg, anhydrous citric acid 240 mg, anhydrous sodium carbonate 200 mg.

Description:

Pharmacotherapeutic group:

Pharmacodynamics:

Acetylsalicylic acid for oral intake in dosages from 0.3 g to 1 g is used to relieve pain and conditions accompanied by fever mild degree, such as colds and flu, to reduce fever and relieve joint and muscle pain.

Acetylsalicylic acid is also used in acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A2. Therefore, it is used in many vascular diseases at a dosage of 75-300 mg per day.

Water soluble vitamin
ascorbic acid is part of the body's defense system against oxygen radicals and other oxidants of endogenous and exogenous origin, which also play important role in inflammatory process and function of leukocytes.

Research results in vitro and ex vivo showed that
ascorbic acid has positive action on the leukocyte immune response in humans.

Ascorbic acid makes a significant contribution to the synthesis of intracellular substances (mucopolysaccharides), which, together with collagen fibers, are responsible for the integrity of the capillary walls.

The addition of ascorbic acid to acetylsalicylic acid reduces gastrointestinal disorders and oxidative stress. These benefits may lead to better tolerability of acetylsalicylic acid with ascorbic acid compared to acetylsalicylic acid alone.

Pharmacokinetics:

Acetylsalicylic and salicylic acids are completely bound to plasma proteins and are rapidly distributed in the body.
Salicylic acid penetrates breast milk and crosses the placenta.

Salicylic acid is metabolized mainly in the liver. The metabolites of salicylic acid are salicyl uric acid, salicylphenol glucuronide, salicylacyl glucuronide, gentisic acid, and gentisin uric acid.

The kinetics of excretion of salicylic acid is dose-dependent, since metabolism is limited by the activity of liver enzymes. The elimination half-life depends on the dose and ranges from 2-3 hours with low doses to 15 hours with high doses.
Salicylic acid and its metabolites are excreted from the body mainly by the kidneys.

After oral administration
ascorbic acid is absorbed in the intestine by Na + -dependent active transport system, most actively in the proximal intestine. Absorption is disproportionate to dosage: with an increase in the daily oral dose of ascorbic acid, its concentration in blood plasma and other body fluids does not increase proportionally, but tends to approach the upper limit.

Ascorbic acid is filtered through the glomeruli and reabsorbed by the proximal tubules under the influence of Na + -dependent process. The main metabolites are excreted in the urine as oxalates and diketogulonic acid.

Indications for use

Contraindications

Hypersensitivity to acetylsalicylic acid, other NSAIDs or any other components of the drug;

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding;

Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nasal mucosa and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, including a history;

Combined use of methotrexate at a dose of 15 mg per week or more;

Severe violations of the liver, kidneys (creatinine clearance less than 30 ml / min);

Severe dysfunction of the heart (chronic heart failure III-IV functional class according to NYHA);

Hemorrhagic diathesis; hemophilia, thrombocytopenia;

Deficiency of glucose-6-phosphate dehydrogenase;

Vitamin K deficiency;

Cerebrovascular or other bleeding;

Inflammatory diseases intestines in the acute stage;

Simultaneous intake of oral anticoagulants and acetylsalicylic acid at a dose exceeding 3 g per day;

Pregnancy (I and III trimesters), breastfeeding period,

Childhood(up to 15 years).

Carefully:

Pregnancy and lactation:

In the II trimester of pregnancy, acetylsalicylic acid can be prescribed sporadically. As a long-term therapy, it is recommended not to use.

breastfeeding period

Salicylates and their metabolites in small quantities pass into breast milk.

When breastfeeding a child, the use of drugs containing acetylsalicylic acid is contraindicated.

Dosage and administration

inside. Dissolve the effervescent tablet in a glass of water and drink after meals.

At pain syndrome weak and moderate intensity and febrile conditions, a single dose is 1-2 effervescent tablets, the maximum single dose is 2 effervescent tablets, the maximum daily dose should not exceed 6 tablets. The intervals between doses of the drug should be at least 4 hours.

The duration of treatment (without consulting a doctor) should not exceed 3-5 days.

In order to reduce the risk of developing adverse reactions from the gastrointestinal tract, the minimum effective dose drug in the shortest course of treatment.

Side effect

Gastrointestinal disorders: often - loss of appetite; rarely - diarrhea; frequency unknown - dyspepsia, abdominal pain, nausea, vomiting, obvious (black stools, bloody vomiting) or hidden signs gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions(including with perforation) of the gastrointestinal tract.

Violations by nervous system: infrequently - headache; the frequency is unknown - dizziness, tinnitus (usually are signs of an overdose).

Blood disorders and lymphatic system: frequency unknown - hemorrhagic syndrome, thrombocytopenia. Bleeding can lead to acute or chronic anemia, iron deficiency anemia with appropriate laboratory and clinical manifestations(asthenia, pallor, hypoperfusion). Patients with glucose-6-phosphate dehydrogenase deficiency may experience hemolysis and hemolytic anemia.

Renal disorders and urinary tract: the frequency is unknown - when used in high doses - hyperoxaluria and the formation urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.

Violations by immune system: frequency unknown - skin rash, rhinitis, anaphylactic reactions, bronchospasm, Quincke's edema, the formation of the "aspirin triad" (bronchial asthma, polyposis rhinosinusitis and intolerance to acetylsalicylic acid and pyrazolone drugs).

Liver and biliary tract disorders: very rarely - Reye's syndrome (acute fatty degeneration liver with developed acute liver failure and encephalopathy); rarely - liver dysfunction (increased hepatic transaminases).

Overdose:

Treatment: with signs of poisoning, induce vomiting or do a gastric lavage, prescribe
Activated carbon and laxative and consult a doctor. Treatment should be carried out in a specialized hospital department under close supervision, if necessary, correction of acid-base balance, electrolyte balance, alkalization of urine, hemodialysis, mechanical ventilation.

Interaction

Glucocorticosteroids, alcohol and alcohol-containing drugs increase the damaging effect on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding.

Increases the concentration of digoxin, barbiturates and lithium preparations in blood plasma. Antacids containing magnesium and / or aluminum hydroxide slow down and impair the absorption of acetylsalicylic acid.

Ascorbic acid improves intestinal absorption of iron preparations. Selective serotonin reuptake inhibitors increase the risk of bleeding in upper divisions GIT.

It enhances the hypoglycemic effect due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from complexes with blood proteins.

Reduces the effect of diuretics by reducing glomerular filtration against the background of inhibition of the production of prostaglandins by the kidneys.

Systemic glucocorticoids, except for hydrocortisone, increase the excretion of salicylates, which can lead to an overdose of salicylates after discontinuation of glucocorticoid therapy.

Increases the toxicity of valproic acid due to its displacement from complexes with blood proteins.

The simultaneous use of deferoxamine with ascorbic acid can increase iron toxicity, especially in the heart, leading to cardiac decompensation.

Special instructions:

Acetylsalicylic acid reduces excretion uric acid from the body, which can cause an acute attack of gout in predisposed patients.

At long-term use the drug should be taken periodically general analysis blood and fecal analysis occult blood, to control functional state liver. Because the
acetylsalicylic acid slows down blood clotting, then the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.

During treatment, the use of ethanol should be abandoned (increased risk of gastrointestinal bleeding).

In the second trimester of pregnancy, a single dose of the drug at recommended doses is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

One dose of the drug contains 933 mg of sodium, which should be considered in patients receiving a salt-free diet.

If necessary, the use of the drug during lactation, breastfeeding should be discontinued.

In order to reduce the risk of developing increased bleeding, the drug should be discontinued 4-8 days before a planned surgical intervention and the doctor should be informed.

Influence on the ability to drive a vehicle:

Does not affect.

Release form:

Package:
2 tablets in a strip of laminated paper aluminum foil; 5 strips with instructions for use in a cardboard pack.

Storage conditions:

Keep out of the reach of children.

Best before date:

Conditions for dispensing from pharmacies:

Registration certificate holder: