The correct dosage of the antihypertensive drug Egilok. Egilok - instructions, application, indications

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Egilok ® (Egilok ®)

Last update of the description by the manufacturer 11.09.2014

Show all release forms (14)

tablets (14)

tablets 25 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166193; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166223; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 60, carton pack 1; EAN code: 5995327166261; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 30, carton pack 1; EAN code: 5995327114620; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

Egilok ®

tablets 50 mg; bottle (bottle) brown glass 30, carton pack 1; EAN code: 5995327114217; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; blister 20, cardboard pack 3; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; blister 15, cardboard pack 4; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 100 mg; plastic bag (bag) 12.8 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 50 mg; plastic bag (bag) 12.8 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; bottle (bottle) brown glass 30, carton pack 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary) Egilok ®

tablets 25 mg; plastic bag (bag) 14.3 kg, polypropylene container 1; No. П N015639/01, 2009-03-17 from EGIS Pharmaceuticals PLC (Hungary)

Egilok

Compound

Tablets of 25, 50, 100, 200 mg.

One tablet of Egilok, Egilok Retard contains 25, 50, 100 mg of the active substance ( metoprolol tartrate ) respectively.

One tablet of Egiloc C, the active substance (metoprolol succinate ) accounts for 23.75, 47.5, 95, 190 mg, respectively .

Excipients for Egilok, Egilok Retard: povidone . sodium carboxymethyl starch . magnesium stearate, microcrystalline cellulose, colloidal anhydrous silica.

Excipients for Egilok C: ethyl cellulose, microcrystalline cellulose, corn starch, metal cellulose, glycerol, magnesium stearate.

Release form

Packed in a cardboard box of 1, 2 and 3 blisters, 10 pcs. in each for 25mg, 50mg, 100mg, 200mg tablets.

Packed in a dark glass bottle: 30 and 60 pcs. for 25 mg, 50 mg and 100 mg tablets.

Round biconvex tablets of white or almost white color. Without smell. Volume: 25 mg, 50 mg, 100 mg.

• On a tablet Egilok 25 mg double beveled cross line on one side, E435 engraved on the other side.
• On a tablet Egilok 50 mg on one side of the risk, on the other side engraved E434.
• On a tablet Egilok 100 mg on one side of the risk, on the other side engraved E432.

Egilok Retard

White biconvex tablets of round shape, scored on both sides. Volume 50 mg and 100 mg.

Biconvex tablets in a white film-coated oval. On both sides of the risk. Volume: 25 mg, 50 mg, 100 mg, 200 mg.

pharmachologic effect

Develops hypotensive, antiarrhythmic, antianginal and beta1-adrenergic blocking stimulation. Causes a rapid decrease in contractions in the heart muscle.

When sinus tachycardia on the background hyperthyroidism and functional problems with the heart, as well as with atrial fibrillation and supraventricular tachycardia the drug can significantly slow down the heart rate up to the restoration of sinus rhythm.

Unlike non-selective beta-blockers, the effect metoprolol on carbohydrate metabolism and insulin production is less significant.

Pharmacodynamics and pharmacokinetics

The drug has a high absorption rate in the gastrointestinal tract. Within 1.5-2 hours after ingestion, Cmax in blood plasma is reached. Under the influence of the active substance, the increased activity of the sympathetic system in relation to the heart is suppressed. From what tablets Egilok with regular use cause lowering cholesterol in blood serum. The bioavailability of the drug increases by 30-40% if taken metoprolol along with food.

The impaired function of the kidneys and liver has practically no effect on the excretion and absorption of the active substance. However, with severe hepatic impairment ( cirrhosis . superimposed porto-caval shunt ) bioavailability increases significantly, and with chronic renal failure increases the risk of unwanted side effects. In old age, the pharmacokinetics of the drug does not change significantly.

After use, the drug passes the full degree of absorbability. Egilok has a weak binding to proteins in the blood plasma (no more than 10%). The drug is excreted from the body mainly in the form of metabolites, only 5% is excreted by the kidneys.

Indications for use Egilok

• prophylactic seizure prevention migraine ;
• high blood pressure;
• impaired functional cardiac activity;
• angina pectoris ;
• disturbed heart rhythm (supraventricular tachycardia and bradycardia with ventricular extrasystoles and atrial fibrillation);
• myocardial infarction .

Indications for the use of tablets also apply to people over 60 years of age.

Contraindications

• SSSU;
• cardiogenic shock ;
• pronounced bradycardia (less than 50 beats per minute);
• lactation period ;
• simultaneous reception of MAO inhibitors;
• age up to 18 years;
• hypersensitivity to the components of the drug in particular, or to beta-blockers in general;
• sinoatrial blockade;
• severely disturbed peripheral circulation;
• bronchial asthma in severe form;
• AV - blockade of 2 or 3 degrees.

Side effects

• In relation to the central nervous system: increased fatigue threshold (very common), headaches and dizziness (often); infrequently - convulsions . decreased attention, depression, increased heart failure . nightmares; rarely - nervous excitability, anxiety state . sexual dysfunction . hallucinations . memory impairment.
• In relation to the senses (rarely): blurred vision .
• In relation to the digestive system (rarely): stomach ache . diarrhea . constipation . dryness in the area of ​​the mucous membrane in the oral cavity.
• In relation to the respiratory system: shortness of breath with physical exertion (often), rhinitis (rarely).
• In relation to the skin (not often): rash . increased sweating .

Instructions for use Egilok

Tablets are taken orally, washed down with a small amount of water. Reception is allowed both during meals (recommended), and on an empty stomach.

Instructions for Egilok Retard and Egilok. The dose is divided into two doses per day, morning and evening.

Instructions for Egilok S. take 1 time per day, in the morning.

How to take (the final dose size and number of doses) the medicine is determined by the doctor individually. The maximum dose is 200 mg. With impaired renal function and with advanced age, redistribution of the volume of the drug consumed is not required.

• Heart failure with compensation: 25 mg per day.
• hyperthyroidism : 50-200 mg per day.
• Arrhythmia : 50-200 mg per day.
• angina pectoris : 50 mg per day.
• migraine attacks (prevention): 100-200 mg per day.
• Tachycardia : 50-200 mg per day.
• myocardial infarction (secondary prevention): 200 mg daily.

Find a doctor for treatment

Overdose

Excessive use of the drug and inconsistent with the doctor leads to an overdose, the most obvious symptom of which is a reaction from the cardiovascular system: slowing of the pulse, heart failure. In some cases, when using the drug by persons under 18 years of age, a negative reaction from the central nervous system is also possible: increased fatigue, seizures, excessive sweating, fatigue.

In case of an overdose, one or more of the above symptoms occur within 20-120 minutes, depending on the characteristics of the organism. High concentration metoprolol in the body, depending on the nature of the symptoms, it is eliminated by gastric lavage, symptomatic therapy, the appointment of adsorbents, atropine sulfate . gluconate . dopamine . norepinephrine .

The use of the drug Egilok with other medications

The list of prohibited drugs for simultaneous use with Egilok is wide. Therefore, it is necessary to combine this drug with third-party medicines with special care.

When mixed with verapamil can cause cardiac arrest.

When mixed with beta-blockers ( estrogens . theophylline . indomethacin ) decreases the hypotensive property of metoprolol.

When mixed with ethanol, the pumping effect on the central nervous system is enhanced.

When mixed with oral hypoglycemic drugs and insulin increased likelihood of hypoglycemia .

When mixed with barbiturates (pentobarbital ) under the influence of enzyme induction, the metabolism of metoprolol is accelerated.

More and more popular among hypertensive patients is egilok, a drug produced in Hungary. Having a pressure-lowering effect, at the same time, Egilok alleviates the condition of the heart affected by complications of hypertension and atherosclerosis. The drug also helps with diseases that are not directly related to high blood pressure. Many patients prefer exactly egilok, ignoring analogues, of which there are many. What motivates them to make a particular choice?

Instructions for use

The name "egilok" is a trademark given to the drug by the manufacturer (Hungary). There is also Indian Egilok.

The INN of egilok is metoprolol. This is the main active ingredient, supplemented by auxiliary: anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch and povidone. Dosage form of release: tablets.

Auxiliary components serve to preserve the base (active substance - metoprolol tartrate) before use. They serve as enterosorbents, emulsifiers, fillers, stabilizers. The components are arranged in such a way that they ensure the stability of the composition and the safety of the drug. Once in the body, they help the main component to fully manifest the desired action.

In Latin, egilok is Egilok, and according to the current beginning it is designated: Metoprolol tartat, if it is a fast-acting form. Prolonged egilok retard contains another metoprolol compound - succinate. Accordingly: Metoprolol succinate.

Tablets are dosed in milligrams of the active substance, three types of dosage: 25, 50, 100 mg. All of them are white or close to white, biconvex. On tablets of a smaller (25 mg) dosage, the surface is marked with a cross-shaped notch. This makes it easier to split (break) the tablet when even smaller doses are needed. Usually - at the beginning of taking the drug, when the optimal dosage is being selected, this is necessary.

Tablets of large dosages have risks that help neat breaking. The tablet preparation has no smell.

Pharmacological group, mechanism of action

Pharmacotherapeutic group of Egilok: beta1-blockers. Egilok refers to cardioselective - drugs of selective action, focused on the myocardium and the coronary vessels that feed it.

Selective beta1-blockers at a reasonable dosage work only with β1-adrenergic receptors, block only them. Another type responsible for respiration, gestation, peripheral vessels - β2-adrenergic receptors - quietly continues to work, egilok is not directed at them. The drug purposefully moves towards the intended target, finds the receptors for which it was created. Contacting them, egilok does not allow catecholamines to produce a strong shake-up of the body with provoking factors:

1. emotional stress;
2. Increased physical activity;
3. A sharp change in the weather (almost 100% of "vascular" patients react to this with a deterioration in their condition).

The sympathetic system under the action of Egilok reduces activity in relation to the myocardium. Egilok, blocking β1-adrenergic receptors, slows down the pulse, reduces four important values ​​​​at once: heart rate, cardiac output, contractility and blood pressure numbers.

Such support to the heart and its vessels improves the quality of life, significantly prolongs it.

When blocking beta1-adrenergic receptors, the heart works calmly. Its blood supply is carried out more fully and without overload, at the moment of relaxation (diastolic phase) of the ventricles. The group's medicines are a lucky find for pharmacists. Egilok () is a typical representative of a number of beta-blockers.

The problem of patients with high blood pressure is left ventricular dysfunction, an increase in the ventricle from excessive load (blood pressure) on it. Regular long-term use of Egilok allows you to reverse this pathology. The ventricle, without experiencing overload, changes its size: it returns closer to normal.

Normalization of the size and functions of the left ventricle, restoration of the time needed for rest (diastole) has a direct impact on the survival of patients. Mortality from vascular accidents, especially in men, is significantly reduced. From what they take Egilok tablets: to prevent such misfortunes as heart attacks, strokes, cases of sudden death. If hypertension is moderate, “mild”, then the therapeutic effect is more pronounced.

The need of the heart muscle for oxygen supply with blood decreases, blood filling increases. The preload on the heart is reduced, it does not need to make as much effort to pump blood as before taking the medicine. Oxygen is absorbed better than it happened at high heart rate and pressure.

The selectivity of Egilok is an advantage over non-selective drugs of the same group. It almost does not show (at adequate doses) a spasmodic effect on the respiratory muscles (bronchi), as well as the smooth muscles of the walls of peripheral vessels. It does not affect the tissues of the muscles that are not included in the myocardial zone. Works only cardiologically, with a positive effect.

Egilok is good for diabetics: without affecting metabolic processes, it does not provoke hypoglycemia. The secretion of insulin does not depend on the presence of metoprolol (egilok) in the blood. Cholesterol levels during long-term therapy with Egilok are significantly reduced.

Pharmacokinetics

The absorption of the active substance after passing through the metabolic barrier of the liver occurs quickly. The process improves with an increase in the percentage of bioavailability, if Egilok tablets, according to the instructions for its use, are consumed with food. The liver controls everything that enters the gastrointestinal tract, so with food it is easier to “slip through” it unchanged to egilok. It becomes more accessible to the body by 40% than taken on an empty stomach. Metabolites lose the therapeutic activity of Egilok.

The percentage of metoprolol binding to blood proteins fluctuates. It is small with a healthy liver, but reaches 10% with its pathology.

The drug is excreted by the kidneys. It can be slowed down in kidney failure, but this does not cause measurable harm.

Indications for use

For egilok, the indications for its use are similar to the use of other beta-blockers. From what these tablets are prescribed, you can understand by examining the mechanism of action of egilok. The drug is used for:

• Hypertensive disease of all stages (arterial hypertension) - monotherapy or as a component in a complex of drugs;
• Tachyarrhythmias (tachycardias) of inorganic origin - functional reversible failures of the myocardium;
• Arrhythmias with organic causes: supraventricular tachycardia, paroxysmal, atrial extrasystole, ventricular, supraventricular;
• Angina pectoris, stable course;
• Prevention of exacerbation of migraine, prevention of pain attacks;
• Hyperthyroidism (removal of symptoms, addition of specific therapeutic methods);
• Angina pectoris complicated by a heart attack - egilok in the complex of basic therapeutic measures. Treatment of a post-infarction condition, simultaneous prevention of recurrence, prevention of a new heart attack.

Instructions for use indicate at what pressure Egilok is effective. It is prescribed for any of the stages of this disease. With a slight excess of the norm of blood pressure, the drug can help alone (monotherapy). Then the instructions for use provide for a minimum - 25 mg of Egilok per reception may already be enough.

Ischemia - narrowing, infringement. In fact, there is no infringement, there is a strong narrowing of the supply arteries. In acute cases, and - blockage of them, closure of the lumen in atherosclerosis (plaques come off), thrombosis (blockage of the vessel by a thrombus). When the lumen of the vessels is narrowed, the nutrition of the myocardium is inevitably disturbed. Egilok relaxes the vessels, facilitates the passage of blood through them to the myocardium. IHD is a form of angina "with experience", its dangerous phase. By improving blood supply, nourishing the heart, egilok helps it survive.

Applied after heart attacks, protects against repeated ones, increases survival

These occur with neurosis, in those suffering from dystonia, other disorders of the nervous system or cardiovascular. Among the whole complex of symptoms, tachycardia often comes out ahead of the rest. It worries more, generates fear, intensifies itself and intensifies the rest of the symptoms. There is no better beta-blocker remedy here. Egilok will take away a frequent pulse and, having some anxiolytic, anti-anxiety effect, will calm a person. At the same time, other unpleasant symptoms will also go away: fear, sweating, tremor. Even a heart that does not have organic changes does not benefit from such an alarming state. The drug will help return everything to normal.

Arrhythmia of organic origin

Complex, severe rhythm disturbances. They are caused by various reasons: atherosclerosis, impaired conduction of myocardial impulses, pathology of the sinus node. Beta-blockers regulate the rhythm during tachycardia (reduce heart rate). Some types of extrasystoles lend themselves to egilok, the rhythm evens out. Or extrasystoles at least become less frequent, acquire a sinus rhythm instead of a chaotic one. The drug egilok is sometimes used even with implicitly expressed bradycardia - for health reasons. Special care is needed here, but it is necessary to save the patient's life. Even Egilok 25 may turn out to be an excess, it is divided, dosed at first with a quarter of such a tablet. And this small dose will still have the desired effect. Almost without slowing down the pulse contractions.

Instructions for use refer bradycardia to the contraindications of egilok, but the reviews of practicing cardiologists indicate: sometimes, in the smallest doses, it is necessary. Grinding (again contrary to the instructions), right under the tongue - for speed of action. This will save a life in an acute situation, and the selection of other drugs - only later.

If the heart rate allows (not too low), beta-blockers help out with this diagnosis. Attacks of angina pectoris, it is not without reason that it is named with the addition of the word "stress", occur during physical or mental overstrain. Egilok, taken constantly, relieves stress. Attacks become rare and manifest weakly.

Migraine, prevention of attacks

The disease is common, but little studied. The culprit of the pain today is considered dilatation (expansion) of the cerebral vessels from overfilling them with blood and high blood pressure.

By lowering blood pressure, egilok warns, blocks dilatation.

Additionally, an anti-anxiety effect works: it has been noticed that migraine attacks are a frequent occurrence in anxious individuals. No anxiety, no migraine.

The disease is not treated with beta-blockers. But with an auxiliary purpose they are used. Egilok will help to calm the frequent pulse characteristic of the disease. Along the way, the intensity of sweating, tremor, and blood pressure decrease. The symptoms of hyperthyroidism are smoothed out, this is important for the patient's well-being.

Prevention of recurrent heart attacks

The drug in combination with others helps protect a person from the risk of a recurrence of a heart attack. The weakened heart may not withstand the second heart attack. Here the role of drugs and the doctor's ability to navigate in their selection, building treatment tactics are vital.

Now you know what egilok helps with. It's time to find out when it's not shown. Contraindications to taking Egilok are:

Use with caution

• Pheochromocytoma - a combination with alpha-blockers is necessary; without them, egilok is not used.
• Diabetes mellitus is a dose-dependent effect; at high doses, stimulation of hypoglycemia is not excluded.
• Metabolic acidosis - there may be an intervention in the failure of the metabolic processes of a beta-blocker with an unpredictable result.
• Bronchial asthma - a small effect on the type 2 receptors that control the respiratory system - β2-adrenergic receptors occasionally in sensitive, asthmatic patients - occurs.
• Obliterating endarteritis, peripheral vascular pathology.
• Insufficiency - renal, hepatic: clearance problems, delayed withdrawal, an increase in the concentration of the drug above the recommended one in the body are possible.
• Depression is a stage of exacerbation or remission.
• Tendency to allergies - if it is necessary to administer anti-shock drugs (adrenaline), the body may not respond to them under the influence of egilok.
• Hyperthyroidism (thyrotoxicosis) - increased hormonal activity of the affected thyroid gland requires careful selection of drugs and doses, even for symptomatic treatment.
• COPD - severe lung disease makes the respiratory system sensitive even to almost neutral selective beta-blockers. The cardioselectivity of Egilok does not exclude micro-influences on other systems. If they are disturbed by the disease, special control is required.

Pregnancy, lactation

If both are at risk: the mother - from the abolition of Egilok, the fetus - from its use, doctors correlate the risks. If possible, a drug that is gentle on the child is selected for the pregnant woman. If such a possibility is excluded, and it is the egilok (according to vital indications) that is needed, they try to save both. The effect of the drug on the developing organism is carefully monitored.

The newborn is immediately examined, checked for possible pathological deviations of systems and organs.

In the presence of such, intensive therapy is carried out, they try to correct the negative effect of the drug obtained in utero.

The child may be under observation for a long time.

Method of application, dosage

Take the drug, not strictly linking the time of admission - with food. Do not wait minutes before or after eating. You can - right along with food, it will even be better absorbed. According to the recommendations of the instructions, the daily dose of Egilok is divided into two doses - morning and evening. The minimum is set based on the condition, concomitant diseases. Start with small doses. By gradual selection reach the optimal. At each such increasing "step" they are delayed up to two weeks - they check the effectiveness.

Daily maximum: 200 mg, no more, the risk of side effects will increase. If the recommended daily dose is exceeded, the selectivity of Egilok is partially lost. The active substance may begin to block both types of adrenergic receptors, which should not be allowed. Doctor's prescriptions should be carried out scrupulously: he knows how much to prescribe, and takes into account all the features of the drug.

The dosage of Egilok according to the type of disease can and should vary. There may be identical doses for some diagnoses.

The dosage of Egilok varies from the initial - 25 mg to the maximum - 200 mg. The selection is individual, stepwise. Reception according to the scheme: morning + evening, the dose is divided in half. Stop at the most comfortable dose that provides the expected effect. Arterial hypertension, detected in time, at the onset stage, can be corrected by Egilok monotherapy. With a persistent course of the disease, high blood pressure, well-combined drugs of other groups that lower blood pressure are added.

Start with 25 or 50 mg, according to the patient's condition and overall drug tolerance. This dosage for IHD is taken twice or thrice a day. The daily dose can be brought up to 200 mg. If such an amount is poorly tolerated, and a smaller amount did not give the desired effect, they are left in a normally tolerated amount. The treatment is corrected by the addition of another drug that complements egilok, which alleviates the patient's condition.

Functional tachyarrhythmia

Appointment: morning and evening - 50 mg. If the effect is insufficient - 100 mg. Usually monotherapy works well.

Extrasystole, tachycardia

Start with 25 or 50 mg. Multiplicity of reception: three times a day. With good tolerance, but low efficiency, the dose is increased. Do not exceed the maximum bar - 200 mg. You can practice the combined treatment of arrhythmias. It is better to start - permanently.

Stable exertional angina

The treatment regimen is similar to the treatment of coronary heart disease, since coronary artery disease is formed during the progression of angina pectoris and is one of its stages.

Prevention of migraine attacks

Dose selection is individual. Usually it is 100 mg divided into two doses. Or - the maximum daily dose of two hundred milligrams. It is also divided in half, taken twice (morning + evening).

If migraine attacks are rare, do not practice continuous use. The approach of an attack is characterized by harbingers (decreased vision, flashing bright spots before the eyes). When such precursors are present, Egilok is immediately taken in a pre-selected dose. Continue for several days.

With often annoying migraine, Egilok is indicated for use - constantly

Up to four doses per day. The maximum daily dose or - close to it (150 - 100 mg).
Prevention of recurrent heart attacks. The maximum or half daily dose of the drug (200 or 100 mg). Divided in two, reception: morning and evening.

Side effects

Egilok has side effects, which is understandable: the drug, even with its selectivity, is in the systemic circulation. Organisms are different, reactivity too. What is useful for most is not suitable for everyone. Undesirable effects from taking Egilok:

• headache, dizziness;
• Inhibition or activation of nervous processes: from excessive excitability to severe fatigue;
• Sexual dysfunction - decreased libido / potency;
• Amnestic-confabulatory syndrome (memory problems);
• Increased unmotivated anxiety;
• Feeling of cold feet;

• Drying of the mucous membranes of the mouth;
• insomnia or drowsiness;
• Symptomatic exacerbation of heart failure;
• orthostatic hypotension;
• hallucinations;
• Painful heartbeat;
• Cardiogenic shock;
• Liver failure;
• Abdominal pain,
• Violation of cardiac conduction;
• Constipation;

• Gangrene (due to aggravation of peripheral circulatory disorders);
• Vomit;
• Tinnitus;
• Conjunctivitis;
• Distortion of taste perception;
• Decreased vision;
• Rhinitis;
• Alopecia;
• Bronchospasm;
• Irritation of the mucous membrane of the eyes;
• photosensitization;
• Shortness of breath on exertion;
• Hives;
• Arthralgia;
• Strong sweating;
• Increased weight gain.

An overdose of the drug Egilok against the background of therapy with blood pressure-lowering drugs, taking barbiurates, in the presence of ethanol taken in the body is more dangerous. Symptoms worsen, prognosis worsens.

Help is needed urgently, hospitalization, a complex of rehabilitation measures are required.

Before the ambulance arrives, if consciousness is preserved, you can give an enterosorbent, try to induce vomiting.

drug interaction

Co-administration with antihypertensive drugs causes an additive effect. Combination therapy is prescribed, started and controlled by a doctor. The total effect is the goal of such treatment, but it should not be excessive. Busting with doses is dangerous with hypotension, which can cause a number of complications. Some of them are more dangerous than pressure rise.

It is risky to combine egilok and other beta-blockers with calcium channel blockers (slow). Especially dangerous is the intravenous use of verapamil, there is a threat of asystole (cardiac arrest).

Antiarrhythmics taken orally (cordarone, quinine) can provoke atrioventricular blockade. Severe bradycardia has not been excluded.

Do not combine egilok with cardiac glycosides: the conductive function of the heart may suffer, severe bradycardia may develop.

Reserpine, some other antihypertensive drugs are not combined with egilok, a representative of beta-blockers. The situation is fraught with hypotension, bradycardia.

If clonidine is still taken with aegiloc, long-term use of clonidine is not currently practiced. It is impossible to cancel drugs at the same time. The sequence is as follows: first stop taking metoprolol (egilok). Clonidine remains "on the drug menu" for several more days. Then it is cancelled. If you do otherwise, remove clonidine first - there is a high probability of two consequences. There is a development of a hypertensive crisis and the formation of drug dependence.

CNS depressants (neuroleptics, tranquilizers, ethanol and other substances of similar action) together with egilok can cause critical hypotension. Urgent recovery measures will be required. And if the user of a beta-blocker is given anesthesia, there is a risk of asystole.

Do not combine alpha- and beta-sympathomimetics with Egilok (sharp hypotension, clinically significant bradycardia, high risk of cardiac arrest).

Ergotamine gives a vasoconstrictor effect, a beta-blocker cannot resist it in this combination.

Egilok has many incompatibilities with drugs. NSAIDs - anti-inflammatory drugs of this type reduce its effectiveness.

Hypoglycemic and insulin activity paired with Egilok - increase (risk of hypoglycemia).

Estrogens "prevent" beta-blockers from lowering blood pressure

Inhibitors of various enzymes, neurotransmitters - the effect of the drug is enhanced by increasing its concentration in the body.

Barbiurates and other enzyme inducers inhibit metoprolol, the effect of egilok weakens.

If substances are used that block the nodes (ganglia) of the sympathetic NS (nervous system), and drugs of the same group with egilok (beta-blockers), even when it is eye drops, special control is needed. The reactions of the body to these combinations are unpredictable.

special instructions

Analogues

Egilok, as the instructions for use reveal, is the same metoprolol (price and place of production differ).

The medicine is effective, common, and necessary for many people. Egilok has many analogues in the country and around the world. Most are given a name that matches the active substance, some - according to the companies that produce them. The price of egilok is not the lowest, nor is it low: for thirty tablets of 100 mg, the patient will pay 130 - 150 rubles. You can buy a cheap analogue of egilok, instructions, composition, properties are the same: metoprolol (after agreeing a replacement with the doctor) is German, the same package is 55 rubles.

The most famous analogues:

• Metoprolol: Russia, Poland;
• Lidaloc: Russia;
• Metoprolol teva: Israel;
• Metolol: Russia;
• Metoprolol ratiopharm: Germany;
• Emsok: Germany;
• Metoprolol organic: Russia;
• Metoprolol zentiva: Slovenia;
• Egilok Retard (prolonged): Switzerland, Hungary;
• Metoprolol-Obl: Russia;
• Metoprolol succinate: India;
• Metozok: Russia;
• Metokor adifarm: Bulgaria;
• Metoprolol tartrate: Ukraine;
• Corvitol 50: Germany;
• Betalok, Betalok ZOK (prolonged): Sweden, France;
• Metocard: Russia, Poland;
• Metoprolol-acry: Russia;
• Vasocardin: Slovenia;
• Betaloc: Sweden;
• Egilok C (prolonged): Hungary;
• Serdol: Romania;
• Egilok: Hungary.

Vacation - prescription.

Pharmachologic effect:
Cardioselective beta blocker without sympathomimetic and membrane stabilizing activity. The main action is hypotensive. Can reduce heart rate. Reduces the severity and frequency of angina attacks, improves the patient's physical well-being, reduces the risk of recurrent myocardial infarction.

It has a certain antiarrhythmic activity. It is most effective for rhythm disturbances with an increase in the number of heart contractions. Egilok slows down the heart rate (HR) by reducing the automatism of the sinus node, slowing down the excitatory impulse, reducing excitability and myocardial contractility.
Prevents a migraine attack.
When taking the product in therapeutic doses, it practically does not affect the smooth muscles of the bronchi and peripheral arteries.

When taken orally, the product has a maximum effect after 1.5 hours after administration. About 5% of the product is excreted unchanged in the urine, the rest is biotransformed in the liver. Therefore, if liver function is impaired, a product accumulation effect may be observed, and dose adjustment may be necessary.

Egilok method of administration and dose:
The dosage is selected by the attending physician in each individual case individually.
With arterial hypertension, the initial average therapeutic dose is 50 mg / day in 1 or 2 doses. If there is no effect or the hypotensive effect is non-cardinal, then it is possible to increase the dosage of the product up to 100-200 mg / day.
With angina pectoris, the product is prescribed at a dosage of 100-200 mg / day in 1 or 2 doses.

With extrasystole and supraventricular arrhythmias, the average therapeutic dose is from 100-200 mg / day in 2 divided doses (morning and evening), if possible evenly distributing the product throughout the day.

For secondary prevention of myocardial infarction, patients are prescribed 200 mg / day in 2 divided doses.
For the prevention of migraine attacks, 100-200 mg / day of the product is prescribed in 2 divided doses (morning and evening).
It should be noted that in patients with severe impairment of kidney and liver function, the product should be dosed with caution, because. cumulation (i.e. accumulation) of the product in the blood is possible.

Egilok contraindications:
- sinus bradycardia with a heart rate of less than 50-60 beats per minute;
- AV - blockade of 2 or 3 degrees;
- sinoatrial blockade;
- syndrome of weakness of the sinus node;
- severe disorders of peripheral circulation;
- arterial hypotension (decrease in blood pressure below 90-100 mm Hg;
- high susceptibility to product components.

Egilok side effects:
From the side of the central nervous system: high fatigue, dizziness, headaches, depression, drowsiness, insomnia, nightmares, decreased ability to concentrate, less often - parasthesia, muscle spasm.

From the senses: rare disorders in the form of visual impairment, conjunctivitis, tinnitus.

From the side of the cardiovascular system: bradycardia (decrease in heart rate), heart failure, less often - conduction disturbance, Raynaud's syndrome.

From the respiratory system: shortness of breath, bronchospasm, rhinitis can rarely be observed.

From the digestive system: nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth, abnormal liver function.

On the part of the skin: photodermatosis, urticaria, erythema, psoriasis-like and degenerative skin changes, alopecia (baldness), increased sweating.

Others: thrombocytopenia, weight gain.

Pregnancy:
The use of the product during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. When using the product during pregnancy, it is necessary to carefully monitor (observe) the state of the fetus in utero, as well as monitor the newborn for several days after childbirth to exclude arterial hypotension, bradycardia (slow heart rate), respiratory depression, hypoglycemia (decrease in blood sugar levels). blood).

Egilok is practically not excreted in breast milk; in the treatment of the mother, constant monitoring of the state of the cardiovascular and respiratory systems of the baby is necessary.

Overdose:
From the side of the cardiovascular system: arterial hypotension, bradycardia, AV blockade, heart failure.
From the digestive system: nausea, vomiting.

Use with other medicinal products:
Simultaneous use of Egilok with digitalis products, nitrates, calcium channel blockers, parasympathomimetics and other hypotensive, antianginal (against angina), antiarrhythmic products increase the risk of arterial hypotension (collapse), bradycardia, AV blockade.

When used with opioid analgesics, there is a mutual enhancement of the action of the products.
Egilok enhances the effect of hypoglycemic (lowering blood sugar) products. When using Egilok in conjunction with alpha and beta adrenomimetics, the risk of arterial hypotension, bradycardia, and sudden cardiac arrest increases.

Estrogens, NSAIDs (non-steroidal anti-inflammatory products), rifampicin, barbiturates can reduce the hypotensive effect of Egilok.
The drug enhances the action of curare-like muscle relaxants.

Release form:
Tablets of 0.025, 0.05 and 0.1 (20,30,60.100 per pack).
Retard tablets of 0.05 and 0.1 (30 each).

Storage conditions:
List B. The product should be stored out of the reach of children at a temperature of 15 to 25 degrees C. Shelf life - 3 years.

Synonyms:
Metoprolol, betalok, vasocardin, corvitol, lopresor, methohexal, metocard, specicor.

Egilok composition:
The active substance is metoprolol tartrate 25 mg, 50 mg.
Auxiliary components: cellulose, sodium starch glycolate, silicon dioxide colloidal anhydrous, magnesium stearate, povidone.

Additionally:
In patients with severe heart failure, the dose should be individually adjusted, starting with the lowest concentration.
Against the background of the use of Egilok, there was an aggravation of peripheral circulatory disorders.

Even in therapeutic doses, Egilok can cause broncho-obstructive complications, especially if the patient has a predisposition in the form of a disease from the broncho-pulmonary system.
In patients with diabetes mellitus and in other patients taking hypoglycemic products, regular monitoring of blood sugar levels is carried out.
When carrying out surgical interventions, etc. , it is necessary to notify the anesthesiologist about taking Egilok.
When prescribing Egilok simultaneously with products that cause depression of the nervous system (hypnotics, tranquilizers, antipsychotics, tranquilizers), the effect may be enhanced, control by a neurologist, psychiatrist is necessary.

In patients whose work and lifestyle require an increased concentration of attention (including driving a car), it is worth deciding on the appointment of the product, only after a thorough examination of the patient. Start driving a car, etc. after evaluating the individual reaction of the patient's body to the product for at least a few days.

Attention!
Before using the medication "Egilok" you need to consult a doctor.
The instructions are provided solely for familiarization with " Egilok».

Beta1 blocker

Release forms

• 30 - dark glass jars (1) - cardboard packs. 60 - dark glass jars (1) - cardboard packs 60 - dark glass jars (1) - cardboard packs. 100 mg tablets - 30 pcs in a pack. tablets 25mg - 30pcs per pack. tablets 50mg - 30pcs per pack. Long-acting, film-coated tablets, white or almost white, oblong, biconvex, scored on both sides. pack of 10 tablets pack of 30 tablets pack of 30 tablets

Description of the dosage form

• 10 - blisters (1) - packs of cardboard. 10 - blisters (2) - packs of cardboard. 10 - blisters (3) - packs of cardboard. tablets tablets Long-acting film-coated tablets Long-acting, film-coated tablets, white, oval, biconvex, scored on both sides. Long-acting tablets, film-coated, white, oval, biconvex, scored on both sides. Long-acting tablets, film-coated tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• Metoprolol succinate 100 mg, which corresponds to the content of metoprolol 95 mg The composition of the film shell: sepifilm LP 770 white - 15 mg (microcrystalline cellulose 5-15%, hypromellose 60-70%, stearic acid 8-12%, titanium dioxide (E171) 10-20%). Metoprolol succinate 25 mg, which corresponds to the content of metoprolol 23.75 mg The composition of the film shell: sepifilm LP 770 white - 3.75 mg (microcrystalline cellulose 5-15%, hypromellose 60-70%, stearic acid 8-12%, titanium dioxide (E171) 10-20%). metoprolol succinate 50 mg, which corresponds to a metoprolol content of 47.5 mg The composition of the film shell: sepifilm LP 770 white - 7.5 mg (microcrystalline cellulose 5-15%, hypromellose 60-70%, stearic acid 8-12%, titanium dioxide (E171) 10-20%). Metoprolol tartrate 100 mg Excipients: anhydrous colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose; in the composition of pellets: macrogol 6000, sugar grains (sucrose, starch syrup), talc; as part of the pellet shell: hyprolose, magnesium stearate, triethyl citrate, ethyl cellulose. The composition of the film shell: hypromellose, macrogol 6000, talc, titanium dioxide (E171). Metoprolol tartrate 100 mg Excipients: anhydrous colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose; in the composition of pellets: macrogol 6000, sugar grains (sucrose, starch syrup), talc; as part of the pellet shell: hyprolose, magnesium stearate, triethyl citrate, ethyl cellulose. The composition of the film shell: hypromellose, macrogol 6000, talc, titanium dioxide (E171). Metoprolol tartrate 100 mg Excipients: microcrystalline cellulose, sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, povidone, magnesium stearate. Metoprolol tartrate 100 mg Excipients: microcrystalline cellulose, sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, povidone, magnesium stearate. Metoprolol tartrate 25 mg Excipients: microcrystalline cellulose, sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, povidone, magnesium stearate. Metoprolol tartrate 50 mg Excipients: anhydrous colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose; in the composition of pellets: macrogol 6000, sugar grains (sucrose, starch syrup), talc; as part of the pellet shell: hyprolose, magnesium stearate, triethyl citrate, ethyl cellulose. The composition of the film shell: hypromellose, macrogol 6000, talc, titanium dioxide (E171). Metoprolol tartrate 50 mg Excipients: microcrystalline cellulose, sodium carboxymethyl starch, anhydrous colloidal silicon dioxide, povidone, magnesium stearate.

Egilok indications for use

• - arterial hypertension (in monotherapy or, if necessary, in combination with other antihypertensive drugs); - chronic heart failure in the stage of compensation (in combination with standard therapy with diuretics, ACE inhibitors, cardiac glycosides); - IHD (secondary prevention of myocardial infarction - as part of complex therapy; prevention of angina attacks); - prevention of cardiac arrhythmias, especially supraventricular tachycardia and ventricular tachycardia caused by adrenergic-dependent prolongation of the QT interval; - hyperkinetic cardiac syndrome; - hyperthyroidism (as part of complex therapy); - prevention of migraine attacks.

Egilok contraindications

• - cardiogenic shock; - AV block II and III degree; - sinoatrial blockade; - SSSU; - Severe bradycardia

Egilok dosage

• 100mg 100mg 25mg 25mg, 50mg, 100mg 50mg 50mg, 100mg

Egilok side effects

• Egilok® is usually well tolerated by patients. Side effects are usually mild and reversible. The side effects listed below have been reported in clinical trials and in the therapeutic use of metoprolol. In some cases, the relationship of an adverse event with the use of the drug has not been reliably established. The following parameters for the frequency of side effects are defined as follows: very often: 10%, often: 1-9.9%, infrequently: 0.1-0.9%, rarely: 0.01-0.09%, very rarely ( including individual messages): 0.01%. From the nervous system: very often - increased fatigue; often - dizziness, headache; rarely - irritability, anxiety, impotence / sexual dysfunction; infrequently - paresthesia, convulsions, depression, decreased concentration, drowsiness, insomnia, "nightmare" dreams; very rarely - amnesia / memory impairment, depression, hallucinations. From the side of the cardiovascular system: often - bradycardia, orthostatic hypotension (in some cases, syncope is possible), coldness of the lower extremities, palpitations; infrequently - a temporary increase in symptoms of heart failure, cardiogenic shock in patients with myocardial infarction, atrioventricular block I degree; rarely - conduction disturbances, arrhythmia; very rarely - gangrene (in patients with peripheral circulatory disorders). From the digestive system: often - nausea, abdominal pain, constipation or diarrhea; infrequently - vomiting; rarely - dryness of the oral mucosa, impaired liver function. On the part of the skin: infrequently - urticaria, increased sweating; rarely - alopecia; very rarely - photosensitivity, exacerbation of the course of psoriasis. From the respiratory system: often - shortness of breath during physical effort; infrequently - bronchospasm in patients with bronchial asthma; rarely - rhinitis. From the sensory organs: rarely - blurred vision, dryness and / or irritation of the eyes, conjunctivitis; very rarely - ringing in the ears, a violation of taste sensations. Other: infrequently - weight gain; very rarely - arthralgia, thrombocytopenia. Egilok® should be discontinued if any of the above effects reaches a clinically significant intensity, and its cause cannot be reliably established.

drug interaction

Overdose

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

Synonyms

• Betaloc, Vasocardin, Corvitol, Metocard, Metolol, Metoprolol, Emzok

For people suffering from high blood pressure, there is usually no question: "Egilok" - what are these pills for? The tool is in the first aid kit of most hypertensive patients, as it is effective, but it is inexpensive (one package is about a hundred rubles, specific figures depend on the characteristics of the release). The drug is made on the basis of metoprolol. "Egilok" is used for pressure in other diseases of the vessels, the heart, helping to alleviate the patient's condition. The drug is available in tablet form and is intended for oral administration. It can only be safe to use in accordance with the instructions for use and in clear agreement of the therapeutic program with the attending physician. The medication is quite strong, so doctors strongly recommend to refrain from self-medication. The instruction to "Egilok" also reminds of this.

Caution is the key to effective therapy

As folk wisdom says, with the right dose, even poison becomes an indispensable medicine, and the most useful and harmless substance in excess threatens a person with death. When it comes to medicines, this wisdom is of particular importance, since excessive (as well as insufficient) intake of a drug into the body may either not improve the patient's condition, or aggravate it. Before use, it will not be superfluous to carefully read the instructions for "Egilok". Even if the attending doctor explained in detail how to use the drug.

"Egilok" is designed for people suffering from high blood pressure, which means that it has a rather strong effect on the functioning of blood vessels, the heart muscle. Not only the state of health of the patient, but also his very life often depends on the correct use of the medication.

How it works?

As can be seen from the instructions, "Egilok" reduces pressure, bringing it to normal levels. The drug fights arrhythmia, normalizes the heart rhythm, normalizes muscle contractions, and also stabilizes the sequence of contractions and excitations. Due to the slowing of the conduction of impulses, the excitability of the heart muscle decreases, which leads to a decrease in the frequency of contractions. Speaking about how much Egilok works, doctors usually mention an hour and a half - it is during this time period that the activity of the drug reaches its peak, after which it remains for some more time.

The predominant part of the substance that enters the body is completely processed in the liver. Here is the accumulation of metabolic products. Five percent leave the body through the urinary system.

What's on sale?

Reviews of "Egilok" contain references to three types of funds. People treat drugs differently. Medicines are on sale under the trade names "Egilok", "Egilok S", "Egilok Retard". A distinctive feature is the composition, although the main active ingredient in all three drugs is the same. "Egilok", "Egilok Retard" are made using metoprolol tartrate, but the third variety is based on a compound of the same metoprolol, but called succinate. In addition, each tablet contains auxiliary components that simplify the absorption of the drug and increase its activity.

In the basic "Egilok" cellulose and silicon dioxide, several other compounds are used as additional compounds. "Egilok Retard" is made with inclusions of magnesium stearate and molasses, talc. Finally, the third option, that is, "Egilok C", contains, among others, stearic acid and several varieties of cellulose, glycerol. When choosing a specific drug, you need to be guided not only by the question "what are these pills from." "Egilok" effectively eliminates pressure, but individual intolerance to any component is possible, prohibiting the use of the agent in question. If, when studying the composition, the patient discovered a substance that his body does not tolerate, it is urgent to notify the doctor about this and select an effective replacement.

When to apply?

Indications "Egilok": arterial hypertension, also known as hypertension. Since the regular use of the drug reduces and normalizes blood pressure, it becomes a permanent inhabitant of the hypertensive first aid kit. The drug can be used as a prophylactic to prevent myocardial infarction. Such use is reasonable if the person belongs to a risk group for pathology.

In some cases, as can be seen from the reviews, "Egilok" is prescribed for migraine, as the remedy prevents headache attacks and reduces their frequency. All of the above indications apply to the three previously mentioned types of medication.

Features of use

"Egilok", "Egilok Retard" are effective in hyperthyroidism, with increased activity of the heart muscle. The tool is used as part of complex therapy to combat the disease. "Egilok", "Egilok S" are effective in supraventricular arrhythmias. Forms of release "C", "Retard" are relevant if there is a failure of the functioning of the heart muscle in a chronic form. The tool is also used as one of the elements in an integrated approach to solving the problem.

Since it is necessary to use the described component together with other drugs to prevent complications, exacerbations, as well as eliminate the symptoms of chronic diseases of the heart and blood vessels, the issue of compatibility is especially acute. "Egilok" enhances the effectiveness of some groups of drugs and is not combined with others. In complex therapy, this group of drugs is usually used together with diuretics, while the pressure drug activates diuretics. PAF inhibitors can be used. A common approach is to combine the drug and glycosides to support the cardiovascular system. But "Egilok" and alcohol categorically do not combine. Therefore, with problems with pressure, it is necessary to refrain from alcoholic beverages, even in small doses. With diagnosed heart failure in an acute form, associated with problems in the functioning of the ventricle on the left, Egilok C gives the greatest efficiency in combination with the above groups of medicines.

Prevention is the best cure

Reviews of "Egilok" demonstrate that the drug is often used as a prophylactic. Known for its effectiveness in the program for the prevention of extrasystoles. In addition, "Egilok C" gives good results in myocardial infarction. The drug can be used even at a late stage, thereby reducing the likelihood of death. With proper use, "Egilok C" allows you to leave tachycardia, problems in the functioning of the heart muscle in the past.

Release Features

The composition of "Egilok" can be found in the instructions for use. This information is always contained on the leaflet in the carton with blisters in which the tablets are packed. The main active components of all three forms of release are indicated earlier, the effectiveness of the agent is due to the presence of metoprolol in it in the form of derivatives.

Reviews of "Egilok" contain a mention that the tool usually has a convex shape on both sides. Only type "C" is usually oblong. The color is always white. One tablet contains the active ingredient in the amount of 25 mg, 50 mg, 100 mg. An indication of this is on the packaging of the drug. Also on sale is "Egilok Retard" with a content of the main active ingredient of 200 mg. The pack contains 30 tablets or twice as many.

When not?

Egilok's contraindications are a rather extensive list, and all of them must be strictly observed, since the drug has a strong effect on the heart muscle. First of all, the ban on the use establishes bradycardia, that is, a slow rhythm of contraction of the heart muscle. If the frequency of contractions decreases to 50-60 per minute, "Egilok" is not applicable.

"Egilok" can not be used with a weak sinus node, sinoatrial blockade. The drug is not applicable for problems with peripheral circulation. The medication should not be used with chronically low blood pressure. The use of Egilok is associated with a certain health hazard if there is a possibility of an allergic reaction. During pregnancy, the use of the described drug must be agreed with the attending physician. There is a possibility of a negative effect on the fetus, so the drug can be used only if the benefit from its use is significantly higher than the risk. If any contraindications are identified, the doctor decides to replace the drug or adjust the dosage of Egilok. You cannot change anything in the program on your own, you must urgently seek advice from a specialist.

How to be treated?

"Egilok" is intended for oral use. The drug is used for violations in the work of the heart and blood vessels on the recommendation of the attending doctor. The dosage, the scheme of application is also determined by the doctor, focusing on the patient's diagnosis, concomitant diseases and other drugs in the therapy program. Below are several options for using Egilok for common diseases. Please note: these are standard programs recommended by the manufacturer, but you cannot prescribe a medication for yourself according to these schemes, you must first undergo a doctor's examination to identify all significant factors.

With arterial hypertension, Egilok is used twice a day, usually in the evening, in the morning. The dosage of the drug is from 25 mg or more. With insufficient effectiveness, the dose is increased to 100 mg per 24 hours. Arrhythmia is treated similarly, the same program is used for angina pectoris. Sometimes the remedy is used three times a day, at a time taking from 25 mg or more. In the absence of a positive effect, the dose is increased to 100 mg, divided into two doses in 24 hours.

Drug programs: what else is there?

When using an agent for the prevention of a heart attack, Egilok is taken every day in an amount of 50 mg (if necessary, the dose is doubled).

If vegetovascular dystonia was detected, if panic attacks were diagnosed that provoked a violation of the rhythm of the heartbeat, Egilok is used in a standard amount, that is, 50 mg. In the absence of a pronounced effect, the amount of the drug is doubled. It is assumed that "Egilok" is drunk twice a day. In the prevention of migraine, the agent is used in the same way.

Overdose: what to do?

When the permissible dose is exceeded, Egilok quite strongly affects the cardiovascular system. Bradycardia develops, dizziness, the patient feels sick. There is a high probability of hypotension, fainting, extrasystole. The rhythm of the heartbeat may be disturbed. In the most severe situations, cardiogenic shock develops, leading to loss of consciousness, up to coma. In rare cases, an overdose provokes cardialgia, atrioventricular blockade. In the absence of help, there is a chance of a complete stop of the heartbeat. Pronounced overdose symptoms appear half an hour or several hours (up to two) after the drug enters the patient's body.

In case of an overdose, it is necessary to urgently wash the stomach, take activated charcoal and conduct symptomatic therapy to eliminate the primary manifestations of the effect of the drug on the body. With a sharp decrease in pressure, the patient is placed in such a way that the level of the head is below the level of the hips. With bradycardia, acute hypotension, with insufficient functioning of the heart muscle, an urgent intake of beta-adrenergic stimulants and a number of specific medications is necessary. In the absence of a quick effect, they resort to drugs containing dopamine, dobutamine. In some cases, the effectiveness shows the use of from a gram to ten grams of glucagon. Depending on the symptoms, diazepam, beta-2-agonists, and an intracardiac electrical stimulator may help. As clinical studies have shown, it is impossible to remove excess drug from the body by hemodialysis.

"Egilok": side effects

And that's not it. Some patients (and this is confirmed by reviews on the World Wide Web) when taking Egilok often feel tired, others complain of increased excitability. Sometimes there is a feeling of anxiety, a depressed state, there are difficulties with concentration. There is a possibility of headaches, the head may be spinning.

"Egilok" in rare cases provokes sleep disorders - nightmares, insomnia or drowsiness. Clinical studies have shown that taking the drug can adversely affect cognitive abilities (first of all, memory suffers), the general condition becomes depressed. With an extremely low probability (and yet it exists), hallucinations, paresthesia, and convulsive states appear. The reviews on the Internet contain references to weight gain with the systematic treatment of Egilok. Laboratory tests may show an increase in the concentration of bilirubin in the blood. There may be problems with the gastrointestinal tract, stool, decreased visual acuity. As it was revealed during the official trials of the drug, side effects accompany the drug intake quite rarely, most patients tolerate the drug well. This is also evidenced by the reviews of doctors and patients.

"Egilok": analogues

If an individual intolerance to the drug is detected, it can be replaced with another, similar medication. Be sure to coordinate the replacement with your doctor. Most often, the reason for adjusting the prescribed drug is an allergic reaction. There are quite a lot of drugs for hypertension in pharmacies, so there is plenty to choose from. Most often prescribed:

• "Metoprolol";
• "Metocard";
• "Metozok".

When studying the analogues of Egilok, it is necessary to be guided, first of all, by efficiency, health benefits, and only then evaluate the cost. The drug is relatively inexpensive (from a hundred rubles per pack), therefore, just for the sake of economy, it is categorically not recommended to replace it with cheaper drugs. Diseases of the heart and vascular system are dangerous not only for everyday activity, but also for life, which requires that the issue be treated very responsibly and coordinate all adjustments to the therapeutic program with the attending physician.

Responsibility as an aspect of successful treatment

High blood pressure is always a danger, even if the disease is not chronic, but only manifests itself from time to time. Often, hypertension is accompanied by other health disorders, which in combination creates a danger to human life. This obliges you to take your health with the utmost responsibility. As a rule, the described drug is chosen by people to whom the attending doctor advised him. If you are going to take the remedy, you need to be prepared for the possible side effects indicated in the instructions (they are listed above). If we systematize the information collected from reviews of the drug, we can see that of the most unpleasant and strong phenomena that occur relatively often, people were worried about problems with the stool.

Feedback on Egilok from experts is mostly positive, since the drug effectively fights the main problem, is inexpensive and accessible to most people. With proper use, interruptions in the work of the heart muscle become a thing of the past, pressure stabilizes. True, Egilok gives a good result only when it really suits the patient. You can’t experiment on yourself, and it won’t work: the drug is dispensed from pharmacies strictly with a prescription from the attending physician.

Hypertension: the first signs

The sooner the treatment of the disease is started, the less blood can be dispensed with, figuratively speaking. When should I go to the doctor, when is it reasonable to start taking Egilok? The first symptoms of hypertension are often ignored - people simply cannot appreciate the full significance of what is happening. As a rule, at the beginning, the disease marks itself with an increase in irritability, frequent dizziness and a state of fatigue. Over time, pressure provokes memory impairment, headaches and weakness.

Noticing such manifestations in oneself, it is necessary to introduce a clear control over the level of blood pressure as a rule. By conducting statistics over a relatively long time period (weeks or even months), you can identify how often the indicators go beyond the norm (120/80), how strong the deviations are. With this information, you can seek help from a doctor.