Cortexin side effects in children. Release form Cortexin. Can I use regular water

Cortexin belongs to the nootropic group and is widely used in the treatment of brain diseases. The medicine is also used to stimulate brain cells in developmentally delayed children.

Cortexin is a complex of water-soluble neuropeptides that penetrate the physiological barrier and exert nootropic, antioxidant, neuroprotective, and tissue-specific effects on nerve cells. The agent is produced in the form of a powder for the preparation of solutions for injections with an active substance obtained from the cerebral cortex of pigs.

The drug is necessary to increase stress resistance, improve concentration and brain function, stimulate the learning process and reduce intoxication from the use of psychotropic drugs. The drug restores brain functions and regulates the ratio of amino acids in the brain, both excitatory and inhibitory.

Use of the drug in pediatric practice

Cortexin is indicated for the treatment of children with CNS lesions from birth, so that the lesions do not pass into or. For older children, it is prescribed as part of complex therapy for the following pathologies:

Cortexin has a beneficial effect on the development of the child and shows a good effect in the treatment of diseases and brain damage in children.

Application features

Cortexin injections are distinguished by their safety and the absence of side effects. The drug is made from natural ingredients, so it does not have a toxic effect.

But there is an individual intolerance to cortexin and an excipient - glycine. Sometimes it causes allergic reactions in the form of itching, rash, swelling. There is also tearfulness or nervousness in the child.

These side effects mainly occur when novocaine powder is used to dilute, which causes such manifestations. For further use, it is necessary to replace it with saline or water.

Injections are painful, which causes additional discomfort and stress to the child, so they are not so painful with novocaine, but in case of bad manifestations, it should be abandoned. With the wrong dosage, the baby may experience convulsions.

It is important to know that the drug for children is available in a small dosage, so you need to buy only it and carry out the treatment recommended by the doctor. In no case should you change the dosage yourself, so as not to harm the health of the baby.

Dosage and course of treatment

The dosage of the drug and the duration of treatment are prescribed by the doctor, based on the age of the child, his disease and the condition of the baby. For babies weighing less than 20 kg, the drug is prescribed at a dosage of 0.5 mg per kilogram of weight. The resulting dose must be administered intramuscularly once a day, the duration of treatment is 10 days.

Children weighing more than 20 kg are taken 10 mg of powder, injections are made once a day for 10 days. If required, the course of treatment can be repeated after 3-6 months. Use the drug until the child is fully recovered.

Injections are given in the morning, because the drug causes excitement, and the child may have difficulty falling asleep.

The solution is injected slowly, then there will be no pain from the injection, this is especially important for people who are allergic to novocaine and for young children.

Cortexin is a drug for intramuscular injection only, for young children such an injection is given in the front of the thigh so as not to damage the sciatic nerve.

It is better to carry out the treatment procedure within the walls of the clinic - in this case, if a side effect occurs, the child will be provided competent, qualified and timely assistance.

For all diseases and disorders of brain activity, the dosage of the drug is prescribed depending on the weight of the baby, age, severity of the pathology and general health.

The appointment is made by the attending physician for each child individually.

Neurologists word

Reviews of doctors on the use of Cortexin in pediatrics for the treatment of children of different ages.

The drug is well tolerated and effective in the treatment of childhood diseases, but it cannot be considered a panacea for all pathologies. The price doesn't match the quality. The injections are painful. The drug improves the higher functions of the brain in children, learning and memory processes, increases concentration. Stress resistance is often observed in children who were injected with Cortexin. I myself prescribe to children, but not often.

Oleg Pedak, neurologist

At 28 weeks, the fetus may experience brain damage, which stops a week after birth. This is called perinatal CNS damage.

Many unfavorable factors fall on the fetus and the newly born child: intoxication, lack of oxygen, infectious diseases of the mother. Childbirth, especially difficult, is also a big stress for the child. All this affects the subsequent development of the baby.

Therefore, the time of the initiated treatment of the newborn with Cortexin plays an important role in the mental development of the child. It is this drug that is used to treat children from the moment of birth, because it has few side effects and is quite effective in restoring brain disorders.

Irina Vlasova, pediatric neurologist

Parents have their own opinion

My daughter was prescribed Cortexin along with Phenibut and massage at 2 months. She also had a small cyst. After the treatment, we went to the neurologist, who said that everything is fine with us. The injections were sick, the daughter cried, but quickly calmed down. The injections were given in the treatment room with insulin syringes.

Olga, Kostroma

My son is 2.5 years old, and he does not speak, so we turned to a neurologist. He prescribed Cortexin, I did not believe in this "miracle", but the result amazed me.

After a week of treatment, the baby began to babble, of course, not in words and phrases, but in his own children's language, but much is already clear. After the push, we will now develop normally. The doctor said, it's good that they didn't delay for a long time, the sooner treatment is started, the better the effect.

Yulia, Zheleznodorozhny

The doctor talks about the features of the drug and how to properly inject and dilute Cortexin injections:

How to replace the medicine

This drug has no analogues. There are drugs that are similar to it in terms of the mechanism of action, but which have in their composition another active substance.

When replacing Cortexin with its analogue, it is necessary to consult a doctor, since analogues can have serious side effects, especially when treating children. Among others, the following drugs should be distinguished:

Cerebrolysin- solution for injection, the active substance is a complex of peptides obtained from the brains of a pig.
Piracetam- solution for injection, the active substance is piracetam.
encephabol- suspension, contains pyritinol dihydrochloride monohydrate.
- syrup, in its composition calcium salt of hopantenic acid.
Actovegin- solution for injection, active substance - deproteinized hemoderivative of calf blood.

Synonyms have a lower price, but more contraindications for use.

Summing up

Nootropics are widely used in pediatrics because they nourish the brain cells and make it function properly.

From the very first days of life, this drug is prescribed for children with brain damage and cerebral palsy, as well as those born prematurely. Premature babies develop faster and catch up with their peers.

Parents of problem babies should not refuse to use Cortexin for the treatment of pathologies. Its analogues may be cheaper in price, but they have many contraindications, including age restrictions. Do not prescribe this medicine on your own, the doctor should examine the child and recommend himself how to treat the baby.

Cortexin belongs to the category of nootropic pharmacological drugs, and is used mainly in therapy for brain ailments. Cortexin contributes to the normalization of metabolic functions in the cerebral cortex, whereby there is a nootropic, anticonvulsant, antioxidant and cerebroprotective effect on the human central nervous system.

The drug is used mainly for craniocerebral injuries, with circulatory failure of the brain, with epilepsy, encephalopathy, vegetative-vascular dystonia.

Impact principle

The main active ingredients of the pharmacological agent are polypeptides obtained from the cerebral cortex of animals (often cattle or pigs). The drug is presented as an injection for intramuscular use. Lyophilizate (powder) is placed in glass vials with a dosage of 5 mg and 10 mg. A dosage of 5 mg is suggested for children.

Polypeptides contribute to the normalization of the level of amino acids, through which the processes of inhibition and excitation of the cerebral cortex are regulated. Cortexin is actively involved in maintaining the balance of the following types of mediators, such as dopamine and serotonin. The nootropic effect that the drug has allows you to normalize memory processes, optimize concentration, as well as increase efficiency and stability in the development of stressful situations. In the course of treatment, an increase in the resistance of brain tissues to a variety of pathogenic effects is observed.

After undergoing a course of therapy with Cortexin, patients experience normalization of memory, the disappearance of headaches, and an increase in interest in learning. In newborns and infants, there are noticeable improvements in development, which are manifested not only by mental, but also by physical activity, for example, babies begin to roll over faster.

The course of treatment with Cortexin improves speech and motor function in children who are diagnosed with cerebral palsy. In people over the age of 50 years after the end of the therapeutic intake of the drug, significant changes are observed, manifested in the form of improved memory, as well as slowing the progression of senile dementia.

After the main active substance enters the body intramuscularly, the breakdown of amino acids and neuropeptides is observed within 3 minutes. It follows from this that it is simply impossible to track the pharmacokinetics. Nothing is known about such properties of the drug as the penetration of active substances into the placenta, liver, as well as the rate of its excretion from the body.

Indications for use

The instructions for use of the drug Cortexin injections indicate that this remedy is indicated in the presence or development of such diseases:

Failures of cerebral circulation.
Present craniocerebral injuries, as well as their consequences.
The epileptic state of the patient.
Asthenia and encephalitis.
Vegetovascular dystonia.
Cognitive impairment through which a person suffers from a disorder of memory, attention and thinking.
Decreased ability to learn and acquire new knowledge.
Problems with the development of speech in childhood.
Cerebral palsy in children.
Perinatal CNS damage in children.

The use of Cortexin has a positive effect on the development of the child, as well as improving the condition of people in old age.

Instructions for use: features of dilution of the drug

It was mentioned above that the remedy is produced in two dosages of 5 mg and 10 mg. Before using the medication intramuscularly, it must be properly diluted. Cortexin is intended for intramuscular use only, both for children and adults. The main types of solvents that are allowed to be used to dilute Cortexin are:

novocaine solution 0.5%;
sterile water for injection;
saline solution is sterile.

Of the above solutions, any can be used to dissolve the lyophilisate, but it is recommended that sterile water or saline be preferred. The use of novocaine is allowed, but not recommended for the simple reason that it increases the risk of developing allergic reactions, and also weakens the therapeutic effect. The advantage of using novocaine is that it has an anesthetic property, that is, it reduces pain when injected. It follows from this that it is necessary to dilute the drug with novocaine in exceptional cases, when a person cannot tolerate the pain of administering the drug. Solvents for diluting Cortexin should be purchased separately, as they are not included in the medicine package.

When buying a pharmacological medication Cortexin, you need to immediately purchase any solvent, and the pharmacist himself will select the necessary dosage of these funds. It is recommended to purchase bottles or ampoules of small volume, which should be opened once for mixing with Cortexin. To dilute the medicine, you will need to apply a solution in an amount of 1-2 ml. To dissolve the lyophilisate, you will need to perform the following steps:

Use a disposable syringe with a 5-dice needle.
Open the solvent ampoule.
Fill the syringe with solvent in the required amount of 1-2 ml.
Remove the aluminum cap from the Cortexin vial.
Punch the rubber stopper with a needle and squeeze the solvent into the vial. Squeeze out the solvent from the syringe slowly to prevent the formation of foam. Foaming will create excess pressure, which can cause the plug to pop out.
When all the solvent has been squeezed out of the syringe, it is necessary to thoroughly stir the medicine until a homogeneous liquid is obtained. The syringe does not need to be removed from the cork. After obtaining a homogeneous consistency of the drug, it is required to fill the syringe in the required dosage.

It is important to know! If, after squeezing the solution into the vial, a syringe with a needle was removed, then this is not scary. Now, a new needle should be used to set the medicine.

After completing the correct preparation of the drug, you can proceed to its introduction. It is forbidden to store the prepared medicine for a long time. After its preparation for 5 minutes, it should be administered intramuscularly. If the prepared injection has stood for more than 20 minutes and has not been introduced, then it is forbidden to use it. Cortexin injections are painful, so during the injection, strong tingling may be felt. Before inserting a needle into the shoulder or gluteal muscle, the skin surface should be treated with medical alcohol. After the injection of the drug, it is necessary to apply a cotton swab with alcohol at the injection site. It is important to note that the injection of Cortexin should be done slowly, despite its pain. Slow administration contributes to the best and fastest absorption of the medication.

About the dosage of the drug

Before using a medication, you should make sure that the correct dosage is known. Often the dosage is prescribed by the attending physician. For adults and children weighing over 20 kg, Cortexin is indicated at a dosage of 10 mg. This dosage is the same for all available indications, except for ischemic stroke. The agent should be used in the indicated dosage once a day, and the course of therapy should continue for 10 days. A second course of treatment is allowed no earlier than after 3-6 months.

With an exacerbation of a stroke, as well as during the rehabilitation period, the medication is administered in an amount of 10 mg 2 times a day. The duration of the therapeutic course is 10 days. After the end of the 10-day course, you should take a break for 10 days, and then repeat the procedure again. A double course of therapy with Cortexin is more than sufficient to cure a stroke, as well as improve well-being during the rehabilitation period. It is recommended to administer the drug in the morning and afternoon. It is not recommended to give an injection in the evening for the simple reason that the medicine can cause insomnia.

If the weight of the child is less than 20 kg, then the dosage of the drug should be calculated individually. For 1 kg of weight, 0.5 mg of the drug is required. The calculated dosage is administered to the child in the amount of 1 time per day for a 10-day course of therapy. Repeat treatment after a 10-day course of therapy is allowed after 0.5 years.

It's important to know! If the procedure for administering the drug was skipped, then its use in a double dose the next day should not be. It is also not necessary to start the course of treatment again. It is necessary to continue using the medicine at the standard dosage, but extending the therapy for one day longer.

Features of use during pregnancy

There is no information on the effect of Cortexin on the fetus during the period of bearing a child, therefore it is forbidden to administer it during pregnancy. When breastfeeding a baby, it is also required to refrain from administering the drug. If it is vital for a nursing mother to undergo a therapeutic course, then the baby needs to be transferred to artificial feeding. It is allowed to resume breastfeeding 1 day after the administration of the drug.

Contraindications

The main contraindications of Cortexin are:

the presence of signs of intolerance;
pregnancy and breastfeeding.

In all other cases, the use of the drug is allowed, but only after the appointment of the attending physician.

It's important to know! It is impossible to mix the medicine with medicines from the peptide family, as this can lead to complications and reduce the effectiveness of the administered drugs.

Terms of purchase and storage

The medicine should be bought only after it is prescribed by a doctor. The drug belongs to class B, so it must be stored under certain temperature conditions: from 2 to 20 degrees. Avoid direct sunlight, which leads to deterioration of the medication.

One of the biggest achievements of domestic medicine is the appearance of the drug "Cortexin", which contributes to the treatment of various pathologies that occur in the brain of the human head. It took almost 30 years to develop the drug. The creation and testing of the drug was carried out by the Military Medical Academy.

Does Cortexin deserve at least one positive review? Practicing clinicians and leading pharmacologists have proven that this drug is the leading drug in the field of brain therapy and most of the concomitant ailments that have a neuronal etiology.

Principle of therapeutic effect

What is Cortexin, and what is its therapeutic effect? The drug is a complex morphological structure with many elements. It consists of the simplest protein components, which are balanced in a certain way from vitamins and other biologically necessary compounds. In combination, all these components of the drug "Cortexin" enable nerve cells to quickly restore their lost functions.

Long-term practice confirms the inefficiency of most rather potent drugs in the treatment of abnormalities in the functioning of the brain of the head. They do not cope with problems due to the inability to overcome this. This is a powerful body defense system that prevents various adverse and aggressive factors from affecting the brain.

Despite the fact that the drug "Cortexin" has a complex structure, it is quite low. This allows the drug to quite easily overcome the described barrier and penetrate into the brain, as a result of which the therapeutic effect is faster and stronger.

The mechanism of action of the drug

The action of the drug "Cortexin" lies in its ability to restore the disturbed balance between amino acids. They affect the activity of important biological processes in the nervous system, memory, intellectual abilities, and also suppress reactions in the form of convulsions, prevent the destruction of neurocytes. Such an effect of "Cortexin" allows its use not only in the field of neurology, but also in the case of mental disorders, in neurosurgery and other therapeutic actions. This versatility of the drug can only cause positive feedback. "Cortexin", in addition to a wide spectrum of action, has one more advantage.

The dose load of the drug on the body is minimal, which contributes to its use, regardless of the age category of patients. Therapy with it can be prescribed to both newborns and people in old age.

Areas of influence of the drug

The positive effect of Cortexin can also be observed in the case Already a few days after the start of taking the drug, the condition of the affected area of \u200b\u200bthe brain and the bed of blood vessels improves, the process of restoring neuropsychic connections that have been broken is accelerated, positive dynamics is observed during the electroencephalogram. In this case, the drug "Cortexin" also acts indirectly, stimulating an increase in blood flow and improving its access to the affected areas of the brain.

The effectiveness of the drug has also been proven in the treatment of symptoms of various neuroinfectious diseases. With it, it is possible to reduce the number of patients suffering from headaches, weakness and dizziness several times over. This fact also causes more than one positive feedback.

"Cortexin" is also used for ophthalmic abnormalities - with damage to the retina or other parts of the optic nerve.

Other areas of influence of the drug

The drug exhibits a rapid rehabilitative effect, which provides a positive effect in the treatment of not only the brain of the head, but also parts of the nervous system remote from it. For example, Cortexin reduces inflammatory reactions in the case of sacral or lumbar sciatica.

Indications for use

The drug "Cortexin" is used for the complex treatment of the following conditions and diseases:

traumatic brain injury;
bacterial and viral neuroinfections;
asthenia;
encephalopathy;
encephalitis;
and memory;
cerebral palsy (its various forms);
reduced ability to learn;
delayed speech and psychomotor development at an early age;
radiculitis;
pathologies of the retina and some others.

Contraindications and side effects of the drug

In some cases, when using Cortexin, allergic reactions occur. Slight redness may appear at the injection site. But pretty soon it disappears, as evidenced by more than one review. "Cortexin" is contraindicated for use in
period of pregnancy and lactation. With individual intolerance to the drug, it is also not recommended for use.

Mode of application

For whatever purpose the drug "Cortexin" is used, its effectiveness depends directly on the stage of the disease, during which treatment was started with it.

The method of introducing the drug into the body is intramuscular injections. The contents of the vials are dissolved either with sodium chloride. The drug is administered daily, once a day. The appropriate dosage for each patient should be prescribed by the doctor.

The recommended amount of Cortexin for newborns and babies weighing less than 20 kg is 0.5 mg per kilogram of the child's weight. The rest is administered 10 mg of the drug daily. The course of treatment is 10 days. It is repeated if necessary. In this case, the break between courses should be at least one month.

Interaction with other drugs

Means "Cortexin" is prohibited to use simultaneously with medical preparations of peptide origin. In the process of its dissolution, Novocain should not be used.

The drug "Cortexin": price

The minimum cost of this drug is 67 rubles per vial (5 mg). At the same time, the lowest price for a package, which includes 10 such bubbles, is 620 rubles. How much does the drug "Cortexin-10" cost? The price of this drug ranges from 100 rubles per bottle to about 1090 rubles per package (meaning 10 vials of 10 mg each).

It happens that during treatment, not only oral medications are required, but injections are also required. Often drugs are available in ready-made liquid form. You just need to draw them into a syringe, and then make an injection. But what if the drug is in the form of a powder? Does it need to be dissolved first? For this, special substances are used: sodium chloride, lidocaine, and so on. Today's article will tell you how to breed Cortexin. You will learn the basic information from the instructions and will be able to familiarize yourself with the method of injection.

"Cortexin": indications for use

Before you dilute "Cortexin", you need to find out important information about this drug. It is known that the drug belongs to the group of nootropics. Therefore, it is unacceptable to use it on its own. This medicine must be prescribed by a doctor. Doctors say that the drug improves cerebral circulation, improves memory, and increases efficiency. It contains an extract of the brain of cattle. According to the instructions, the medicine is prescribed for the following indications:

encephalopathy of various origins (including in newborns);
circulatory disorders in the brain;
encephalomyelitis chronic or acute;
epileptic conditions;
vegetovascular dystonia;
trauma to the brain and its membranes;
neuroinfection caused by viruses or bacteria;
cerebral palsy, delayed development of speech and motor skills in children;
memory impairment, inability to learn.

The drug is not used during pregnancy and breastfeeding, as well as if there is an individual intolerance to its composition. Before using a nootropic, it is important to ask your doctor how to properly dilute Cortexin. If you do not have experience with injections, then it is better to entrust this manipulation to a specialist. Particular care must be taken when it comes to the treatment of young children.

Preparation method

You already know that the medication is available in the form of a powder. The lyophilisate is placed in transparent glass ampoules. On top there is a metal ring that protects the inlet. For convenience, it has a special folding zone. Open it.

Before diluting Cortexin, be sure to wash your hands. The palms must be sterile to prevent infection. Open the syringe and draw the selected solvent into it. You will learn about them further from the article. After that, insert the needle into the rubberized cap and gradually pour in the liquid. Be careful not to create foam. The amount of solvent should be at least 1, but not more than 2 milliliters. Wait for the formation of a homogeneous substance, after which draw the liquid back into the syringe. Consider how to dilute "Cortexin" with water for injection, novocaine and other solvents in more detail.

"Procaine": how to dilute the powder?

So, you have been prescribed Cortexin. How to dilute 5 mg of the active substance? To do this, you can use a solvent with the trade name "Procaine". We note right away that it is rarely recommended. This medicine has a moderate anesthetic effect. The drug after intramuscular injection undergoes systemic absorption in full. The solution "Procaine" is used for the preparation of various agents in anesthesiology. It is not recommended to dilute "Cortexin" with this solvent for persons with cardiac, renal and hepatic insufficiency. Also, the medication is not prescribed for children (it is replaced with another solvent).

Before diluting Cortexin, open the ampoule of procaine. To prepare this medicine, you will need a solvent at a concentration of 5 mg per 1 ml. Mix the ingredients as described above.

Novocaine solution

A more popular analogue of the previous medicine is novocaine solution. This medication also has a mild anesthetic effect. It is used in various fields of medicine, including neurology. Sometimes this solvent is recommended for babies (if there are no contraindications). How to breed "Cortexin" with novocaine? Children are prescribed one milliliter of liquid. Mix the solvent with the powder, then draw the medicine into the syringe.

It is known that novocaine solution accumulates in nerve fibers. Due to this, the pain impulse is reduced. The drug is not used for intramuscular injection for more than 10 days in a row. "Cortexin" is usually prescribed for just such a period. If you are prescribed a nootropic for a longer time, then it is advisable to choose a different solvent for its preparation.

Can Cortexin be diluted with sodium chloride?

One milliliter of this solvent contains 9 milligrams of sodium chloride, and additional substances are also present. The drug is produced in different forms. Often, consumers purchase large volumes of the drug for nasal irrigation or inhalation. In this form, it is better not to use the tool, as there is a possibility of infections getting into it. How to breed "Cortexin" in such a situation?

Purchase ampoules for injection at the pharmacy. Often a solution of sodium chloride is called saline. It is permissible for an adult to use from 5 to 300 milliliters of medication per day. Of course, for the preparation of "Cortexin" so much is not needed. If you are going to inject an adult, then use 2 milliliters of sodium chloride. Can Cortexin be diluted with saline for a child? It is possible, but for babies it is better to use 1 milliliter of sodium chloride. With prolonged use of such a drug, it is necessary to control the amount of electrolytes in the patient's blood and urine.

Water for injection: instruction

Can Cortexin be diluted with water for injection? Yes, this practice also exists. Water for injection is available in separate glass or plastic containers of 1, 2 and 5 milliliters. The drug is intended for subcutaneous, intravenous and intramuscular administration. But from the instructions it is known that Cortexin is injected exclusively into the muscle zone.

The abstract says that it is necessary to dilute "Cortexin" with water for injection under sterile conditions. This solvent has no contraindications for use. It is often prescribed to children and adults. It is forbidden to dilute powders for injection with the described substance only in cases where the instruction provides for the use of another substance.

Can regular water be used?

Consumers often ask questions: "How to dilute Cortexin and is it possible to use ordinary water for this?" After all, the instructions do not say a single word about such restrictions. Does this mean that such actions are allowed? What do doctors think about it?

The medicine "Cortexin" is strictly forbidden to be mixed with ordinary water. Even if you previously filtered and boiled the liquid. Despite all the cleaning procedures carried out at home, you will not be able to get a sterile solution. The bacteria in the water may die, but remain there, which will provoke intoxication. If such a solvent is used to prepare a nootropic drug, then the consequences can be the most unexpected. Remember: it is forbidden to dilute "Cortexin" with drinking water, it is dangerous!

Lidocaine: pros and cons

Can Cortexin be diluted with lidocaine solution? After all, this drug also applies to solvents. In addition, lidocaine is a strong anesthetic. Often it is used for injections for the purpose of pain relief. Let us make a reservation right away that the Cortexin nootropic is not characterized by painful administration. Therefore, there is no urgent need for the use of lidocaine.

If you listen to the doctors, you can find out that they do not recommend mixing Cortexin with Lidocaine. Why? The fact is that the powder contains amino acids. They are under the influence of "Lidocaine" begin to collapse. Such a combination will lead to the fact that the treatment will be ineffective. Do not dilute Cortexin with Lidocaine!

"Cortexin": what is better to breed?

You have learned that there are several solvents for preparing medicines. Which of them should be preferred? After all, you want the treatment to be correct and effective. It is forbidden to use "Lidocaine" and ordinary sterile water for the preparation of injections. Also, the powder is not diluted with oil additives. Doctors do not even consider such a possibility.

If you are assigned "Cortexin", the doctor will tell you the better to breed. For young children, water is usually used (for injection). It is safe and does not cause negative reactions. "Novocaine" and "Procaine" can also be used, but it is worth remembering that these drugs can cause allergies. Reviews say that the use of water for injection makes the injection quite painful. If your child is not allergic to the components of Novocain, then you can safely use it. This solvent is ideal for preparing an injection. When there is an allergy, give preference to a solution of sodium chloride or water for injection. Be sure to discuss this issue with the doctor prescribing the nootropic.

Instructions for use "Cortexin"

The drug is always administered only in a diluted form. Surely you have already chosen the appropriate solvent together with the doctor. Now it is worth paying attention to the dosage. It is selected individually for each patient.

Newborn babies and young children are prescribed one injection per day. An ampoule with a dosage of 5 milligrams must be diluted with one milliliter of a suitable solvent.
For children whose body weight is less than 20 kilograms, the drug is calculated separately. For every kilogram of weight should be 0.5 mg of the active substance. For example, if a child weighs 15 kilograms, then he is prescribed 7.5 milligrams of Cortexin. This amount is present in 1.5 ampoules.
For adult patients and children whose body weight exceeds 20 kilograms, the drug is prescribed 10 milligrams per day. This is the volume of two ampoules. If each is diluted with 2 milliliters of water, you get 4 ml of the drug.

Before making an injection, it is imperative to disinfect the skin. Wipe the injection site with an alcohol wipe. Inject the medicine slowly, after releasing all the air from the syringe. The duration of treatment is usually 10 days. If necessary, it is possible to repeat the course after the same period of time. The specialist may prescribe periodic repetitions for several months. It all depends on the indications and the general condition of the patient.

Summarize

From the article, you learned how to dilute Cortexin with water for injection and other solvents. The instructions are also described in detail for you: indications and contraindications, method of using the drug. Remember that "Cortexin" refers to nootropics. It should only be used as directed by a doctor. Do not forget to check with the doctor how and in what dose to dilute the powder. All the best to you, do not be sick!

To improve brain activity, activate metabolic processes in brain tissues and eliminate various neurological pathologies, children are often prescribed nootropic drugs. One of them is the drug of the domestic pharmaceutical company Geropharm, called Cortexin. When is it prescribed to a child and how to properly treat babies with such a medication?

Release form and composition

Cortexin is presented in pharmacies in only one form - injectable. It is sold in boxes containing 10 glass bottles with a white or yellowish-white powder (lyophilizate). It may also look like a porous homogeneous yellowish or white mass.

The main ingredient of such a powder is polypeptide fractions, the molecular weight of which does not exceed 10 thousand Da. Such protein molecules with a small length and mass are a water-soluble complex and are also called cortexin. Their number in one vial can be 5 mg or 10 mg. These polypeptides are extracted from the brain of pigs or cattle (from the bark).

Glycine is added as a stabilizer to the drug. Its dosage is 6 mg in vials with 5 mg of the active complex (the drug contains 11 mg in total, and the volume of the vial is 3 ml) and 12 mg in the preparation with 10 mg of cortexin (there is a total of 22 mg of powder inside, and the volume of the vial is 5 ml) .

Operating principle

After injection, low molecular weight protein molecules of Cortexin pass through the blood-brain barrier and have the following effect on the brain:

They stimulate both nerve cells and neurotrophic factors, due to which information is better and faster transmitted through the fibers, and the balance of excitatory and inhibitory mediators is normalized.
They protect neurons from various damaging factors, for example, from hypoxia, free radicals or calcium ions. Such a therapeutic effect of the drug is called cerebro- or neuroprotective. It makes nerve cells more resistant to any external influences, including stressful situations and taking various psychotropic drugs.
They activate metabolic processes in the brain tissues and accelerate the recovery of nerve cells, as a result of which the overall tone and functions of the central nervous system improve.
They have a positive effect on the ability to learn new material and work. This is what is called a nootropic. It consists in improving the functions of thinking, among which attention and memory are especially important.
Reduce convulsive activity in lesions of brain tissue. Due to this influence, the use of Cortexin helps prevent the occurrence of seizures.
They slow down oxidative processes in brain cells, that is, they act as an antioxidant.

Indications

Cortexin in childhood is prescribed:

With craniocerebral injuries or to eliminate their consequences.
With encephalitis or encephalomyelitis.
With speech delay.
With epilepsy.
With neuroinfections caused by viruses or bacteria.
With a delay in psychomotor development.
With circulatory disorders in the brain.
With encephalopathy.
With hydrocephalic syndrome.
For problems with memory or attention.
With asthenia.
With cerebral palsy.

What age is allowed?

Cortexin can be administered to children of any age, including infants in the first year of life. Such a remedy is used even in premature babies, if there are serious indications for this, for example, with birth trauma, neuroinfection or hypoxia during childbirth.

Contraindications

The drug is not used in children with intolerance to its components. There are no other contraindications for this medication. However, if the baby gets sick during the course of therapy, you should definitely consult a doctor and discuss the withdrawal of the medication. As a rule, for colds, flu and other acute respiratory viral infections, injections are not given, but the treatment is postponed for the period when the child fully recovers.

Side effects

Sometimes treatment with Cortexin provokes an allergic reaction, such as a rash or itching of the skin. If the injection site turns red, rashes appear, or the child complains of pain and burning, the baby should be shown to the doctor.

Instructions for use

Cortexin is administered only intramuscularly. Before injection, the lyophilisate must be diluted. Dilution of the powder is performed immediately before the injection. For this purpose, sterile water intended for injection is used, as well as sterile saline.

It is possible to dilute the medication with a 0.5% solution of novocaine, however, such a solvent is used much less frequently. Although it reduces the pain of the procedure, when diluted with an anesthetic, the therapeutic effect of Cortexin decreases, and the risk of allergy to the injection increases. For this reason, the use of novocaine is recommended only if the child is difficult to tolerate injections and they are very painful for him, and there is no allergy to novocaine in a small patient.

To dilute Cortexin, you must first draw up a solvent in a volume of 1-2 ml with a sterile syringe, then remove the foil from the vial of lyophilisate and pierce the rubber stopper. Next, the solvent should be carefully released into the vial so that foam does not form (for this, it is advised to direct the jet of liquid to the wall so that the solvent slowly flows onto the powder).

After releasing all the water or saline solution and without removing the needle, you need to gently shake the vial until the powder is completely dissolved. As soon as the solution becomes homogeneous and transparent, it is drawn back with the same syringe, and then an intramuscular injection is performed.

It is important to remember that the entire lyophilisate is diluted for one injection, and then the required amount of medication is collected. It is unacceptable to divide the powder into parts, and then dilute only one of them.

The medication is advised to be injected into the muscles of the shoulder or thigh. To reduce pain, the injection should be performed with a thin needle, and the medicine should be administered very slowly. The next injection is made, departing from the place of the previous at least 1 cm.

Dosage

For babies weighing up to 20 kg, the dose should be calculated by weight. To do this, the number of kilograms is multiplied by 0.5, for example, if a child weighs 8 kg at 10 months, then he needs 8x0.5 = 4 mg of cortexin per day. For such a baby, they take vials with 5 mg of the active ingredient, dilute 2 ml of water for injection and inject 1.6 ml of the finished medicine into the baby (it is from this amount that the baby will receive 4 mg of the active complex). If the medication is diluted with 1 ml of saline or sterile water, then the child needs to inject 0.8 ml. The remainder of the drug is discarded.
For a child weighing more than 20 kg, Cortexin is prescribed 10 mg per day. One vial with this content of the active complex is diluted with 1 ml of water for injection or saline.
The drug is administered daily 1 time for ten days. An injection is recommended to be done in the morning, because the medication has a stimulating effect. After a 10-day course of treatment, a break is made for 3-6 months, after which the therapy can be repeated.
In stroke, 2 injections of 10 mg are performed daily. One of them is done in the morning, and the second - in the daytime, since an injection made in the evening can interfere with falling asleep.
If for some reason the injection was missed, the next day you do not need to administer the drug in a double dose. In such a situation, the course is extended so that a total of 10 injections are obtained.

Overdose

For the entire period of use of the drug in children, there were no cases of overdose.

drug interaction

Cortexin does not have any negative effect on other drugs, so it can be used in conjunction with various medications. In this case, the drug cannot be mixed in one syringe with any other solutions, except for permitted solvents. If several injections are prescribed, they should be administered as separate injections.

Terms of sale and storage

Buying Cortexin in pharmacies is possible only if you have a prescription for such a medication obtained from a pediatrician, neurologist or other specialist. The average price of 10 ampoules, which contain 10 mg of the active compound, is 1200 rubles. Separately, you should purchase a package with 1-2 ml ampoules of saline or water for injection.

It is recommended to keep the box with bottles at home at a temperature below +25 degrees in a place where the product will be hidden from sunlight and inaccessible to children. Shelf life of sealed vials with powder is 3 years from the date of manufacture. Diluted medicine can be stored no longer than 20 minutes. If for any reason more time has passed after mixing with the solvent, the syringe with the drug should be discarded, and then diluted and the lyophilisate taken from a new vial.

Reviews

There are a lot of good reviews about the treatment of children with Cortexin. In them, mothers note that after a course of injections, the child speaks better, memorizes poetry easily, memorizes new information, becomes less nervous, and expands his vocabulary. In the smallest, the medicine accelerates motor development. According to parents, after injections, babies quickly learn to roll over on their tummy, sit, stand up, hold a spoon, learn to crawl, and so on.

When treating schoolchildren, mothers confirm the positive effect of Cortexin on thinking, attention and memory. In children of this age, the drug effectively helps with low learning ability, difficulties in mastering the material, problems with speech. Doctors also emphasize that injections help eliminate the negative effects on the brain of stress, hypoxia, trauma and other factors. However, many doctors, including Komarovsky, classify Cortexin and other nootropics as drugs whose effectiveness has not been proven.

The drug is well tolerated by most young patients. Local reactions to injections occur very rarely and often when the powder is diluted with novocaine. In negative reviews, they complain about the high cost of the course of treatment, the severe pain of injections, and in some children they note the absence of any positive effect on the nervous system. Also, many parents do not like that the drug is released only in injectable form, so they choose analogues in tablets.

Analogues

Instead of Cortexin, children may be prescribed other drugs with a similar therapeutic effect:

Cogitum. This medication in the form of a sweet banana solution in ampoules is in demand for RDD, asthenia, perinatal CNS damage, neuroses and other problems. He is appointed from the age of 7.
Cerebrolysin. The action of this drug in ampoules for intravenous or intramuscular injections is provided by peptides that are obtained from the brain of pigs. The drug is used in children with traumatic brain injuries, organic or metabolic diseases of the brain. It is prescribed to children at any age, if there are indications for this.
Aminalon. These coated tablets work thanks to gamma-aminobutyric acid. They are prescribed for problems with attention, cerebral palsy, mental retardation, depression, drowsiness, motion sickness, appointing children older than a year.