Release form and recommended prices. Pain in diabetic neuropathy

The analogues of the drug carbamazepine are presented, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more identical active substances. When choosing synonyms, consider not only their cost, but also the country of origin and the reputation of the manufacturer.

Description of the drug

It has a moderate anti-manic, antipsychotic effect, as well as an analgesic effect for neurogenic pain. The mechanisms of action may involve GABA receptors, which may be associated with calcium channels; also, apparently, the effect of carbamazepine on neurotransmission modulator systems is important.

The antidiuretic effect of carbamazepine may be due to the hypothalamic effect on osmoreceptors, which is mediated through secretion of ADH, and also due to a direct effect on the renal tubules.

List of analogues

Note! The list contains synonyms for Carbamazepine, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

Reviews

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Official instructions for use

Carbamazepine

International non-proprietary name: Carbamazepine* (Carbamazepine*)

Dosage form: tablets
Compound: one tablet contains as active substance– Carbamazepine 0.2 g; excipients: potato starch, aerosil, magnesium stearate, talc, povidone, tween-80.
Description: tablets of white or white color with a yellowish tint, flat-cylindrical shape with a risk and a chamfer.
Pharmacotherapeutic group: antiepileptic agent.

Pharmacological properties

Indications for use

Contraindications

Dosage and administration

Side effects

Overdose

Interaction with other drugs

special instructions

Release form

Storage conditions

Best before date

Holiday conditions

Manufacturer

The information on the page was verified by the therapist Vasilyeva E.I.

Photo of the drug

Latin name: Carbamazepine

ATX code: N03AF01

Active substance:

Producer: Rozpharm LLC (Russia), ALSI Pharma (Russia)

The description applies to: 25.10.17

Carbamazepine is an anticonvulsant drug with antiepileptic, normothymic and antidepressant properties. Produced in the form of tablets.

Pharmacological action of Carbamazepine

In accordance with the instructions for Carbamazepine, active active component medication is carbamazepine. Auxiliary substances that are part of the drug are potato starch, stearic acid, aerosil.

Carbamazepine has a pronounced neurotropic and psychotropic effect on the body.

When using Carbamazepine, the substances that make up the drug have an antiepileptic effect due to their activity in relation to the causes of partial seizures of simple and complex type with or without secondary generalization. The drug is effective in tonic-clonic convulsions.

The drug contributes to the stabilization of active membranes nerve cells, dulls the occurrence of repeated discharges of neurons, reduces the synaptic propagation of impulses responsible for excitation. The anticonvulsant effect of carbamazepine is due to the prevention of repeated discharges (due to the blockade of sodium channels), as well as the normalization of neuronal membranes and a decrease in the release of glutamate.

The instructions for Carbamazepine noted that the drug helps prevent attacks of trigeminal neuralgia.

The antipsychotic property of the drug is due to the inhibition of the exchange of norepinephrine and dopamine in the brain.

When using Carbamazepine orally, the drug is completely absorbed. The maximum concentration in the blood after a single dose is reached within 24 hours. Eating does not affect the rate and degree of absorption of the drug. Carbamazepine tablets are highly bioavailable. Metabolized medicinal substance in the liver with the formation of several metabolites. The period of complete elimination of the drug from the body with a single use is 72 hours, with repeated use - up to 48 hours. Carbamazepine is excreted by the kidneys.

In reviews of Carbamazepine, there are no changes in metabolism in the elderly.

Indications for the use of Carbamazepine

The drug is prescribed to patients who have:

• Epilepsy, accompanied by partial seizures with simple and complex symptoms, as well as primary and secondary generalized forms of seizures with tonic-clonic convulsions, with the exception of absences, myoclonic and flaccid seizures;
• Idiopathic trigeminal neuralgia, including neuralgia with multiple sclerosis;
• Idiopathic glossopharyngeal neuralgia;
• Pain syndrome in diabetic polyneuropathy;
• Polydipsia and polyuria in diabetes insipidus.

• Psychotic disorders, psychoses, dysfunctions of the limbic system, panic disorders;
• Aggressive behavior caused organic lesions brain, chorea, depression;
• Dysphoria, anxiety, tinnitus, somatization, Klüver-Bucy syndrome, senile dementia;
• Tassel dorsalis, acute idiopathic neuritis, multiple sclerosis, diabetic polyneuropathy, hemifacial spasm, Ekbom's syndrome, postherpetic neuralgia.

In reviews of Carbamazepine there are messages that indicate high efficiency drug in the treatment and prevention of migraine.

Method of application and dosage

Carbamazepine tablets are intended for oral administration during meals.

For the treatment of epilepsy, adults are prescribed the drug at an initial dose of 1 tablet 1-2 times a day. Elderly people are recommended to take ½ tablet 1-2 times a day. Subsequently, the dose should be gradually increased until taking 2 tablets 2-3 times a day. The maximum daily dose of Carbamazepine should not exceed 6 tablets.

The daily dosage of Carbamazepine for children under 1 year is 0.5-1 tablet per day, 1-5 years - 1-2 tablets, 5-10 years - 2-3 tablets, 10-15 years - 3-5 tablets. The daily dose should be divided into 2 doses.

For the treatment of neuralgia and pain syndromes of various genesis, the daily dose is 1-2 tablets of Carbamazepine, divided into 2-3 doses. 2-3 days after the start of the medication, the dose can be increased to 2-3 tablets. The duration of therapy is 7-10 days. After an improvement in the patient's condition is noted, the dose should be gradually reduced to the minimum effective. Maintenance dosage is recommended to be taken for a long time.

With withdrawal syndrome, according to the instructions, Carbamazepine is prescribed to take 1 tablet 3 times a day. In severe cases, during the first three days it is recommended overdose drug - 2 tablets 3 times a day.

For the treatment of polydipsia and polyuria in diabetes insipidus, you should take the medicine 1 tablet 2-3 times a day.

Side effects of Carbamazepine

In accordance with reviews of Carbamazepine, side effects from the body may occur when taking the medicine. Individuals may experience dry mouth, loss of appetite, nausea, headaches, vomiting, dizziness, ataxia, drowsiness, and disturbances of accommodation.

At patients of advanced age excitation and confusion of consciousness are noted.

In rare cases, hyponatremia is noted, which occurs due to the antidiuretic effect of carbamazepine.

May also occur allergic reactions, accompanied skin rashes and dermatitis, as well as agranulocytosis, leukopenia and thrombocytopenia, aplastic anemia, cardiac conduction disorders, proteinuria, edema, cholestatic hepatitis, interstitial nephritis, gynecomastia, lymphadenopathy.

Contraindications to the use of carbamazepine

The drug is not prescribed for people who are hypersensitive to its components.

Contraindications are:

• atrioventricular block;
• glaucoma;
• hematological diseases;
• prostatitis;
• violations of the functions of the liver, cardiac activity, kidneys and sodium metabolism;
• bone marrow diseases.

Overdose

In reviews of Carbamazepine, it is reported that in case of an overdose of the drug, there may be increased arousal, tremor, convulsions, clouding of consciousness, changes in blood pressure, coma.

Additional Information

Therapy with Carbamazepine should begin with small doses, gradually bringing them to the required therapeutic level.

The instructions for Carbamazepine indicate that the medicine must be stored in a dark, cool and out of the reach of children. Shelf life - 36 months.

From drugstores it is released according to the recipe.

• Finlepsin
• Tegretol
• Actinerval
• Zagretol
• Zeptol
• Karbasan retard
• Mazepin
• Stazepin
• Storylat

Price

average price online*, 213 p.

Where could I buy:

Instructions for use

Carbamazepine is an antiepileptic drug with a psychotropic effect. Available in the form of white tablets or white-yellow color, active substance is carbamazepine.

Indications

Indications for the use of Carbamazepine are:

• Epilepsy, simple and complex seizures, seizures of mixed forms.
• Acute manic states and bipolar affective disorders.
• Trigeminal neuralgia.
• Alcohol withdrawal syndrome.
• Pain in diabetic neuropathy.
• Polyuria and polydipsia in diabetes insipidus, only of a neurohormonal nature.

Dosage and administration

Carbamazepine tablets are taken orally, their use does not depend on food intake, washed down with a small amount of water.

Dosage of the drug:

• With epilepsy - adults take 100-200 mg of the drug 1-2 times a day, gradually increasing the dose to 400 mg 2-3 times a day, the daily dose should not exceed 2000 mg. Children under 5 years of age are given the drug, starting with 20-60 mg, every two days the dose is increased by 20-60 mg. The initial volume for children over 5 years old is 100 mg, increased by 10 mg every week.
• With trigeminal neuralgia - start with 200-400 mg per day, then gradually increase the dose by 200 mg, after elimination pain the dose is reduced. For the elderly, the starting dosage is 100 mg twice daily.
• With alcohol withdrawal syndrome– The average dosage is 200 mg three times a day.
• With polyuria and polydipsia - the standard dosage for adults is 200 mg in two to three doses, the children's dose is calculated based on the age and weight of the child.
• For pain of diabetic neuropathy - 200 mg two to four times a day.
• In acute manic states and bipolar affective disorders - from 400 to 1600 mg in two to three doses, the dose is increased gradually, but if necessary, a rapid increase is allowed.

Contraindications

Contraindications to the use of Carbamazepine:

• AV block.
• Inhibition of bone marrow hematopoiesis.
• Simultaneous reception MAO inhibitors, also you can not use carbamazepine within two weeks after the withdrawal of inhibitors.
• Hepatic porphyrias.
• lactation period.
• Hypersensitivity to the components of the remedy.

In addition to critical contraindications, the drug should be used with caution in such conditions:

• Low level platelets or leukocytes.
• Mixed forms of epileptic seizures.
• Elderly age.
• Heart failure.
• Renal and liver failure.
• High intraocular pressure.
• Hypothyroidism.
• Hyperplasia of the prostate.
• Pregnancy.

Pregnancy and lactation

The drug Carbamazepine is not recommended during pregnancy, as the risk of fetal disorders, including malformations, is greatly increased. The lactation period is one of the main contraindications to the use medication.

Overdose

Conditions arising from an overdose of the drug:

• Depression of the central nervous system, ranging from drowsiness and disorientation, and up to coma.
• Pulmonary edema.
• Tachycardia, decrease or increase in pressure.
• Metabolic disorders, bouts of vomiting.
• Urinary retention.
• Hyperglycemia.
• Hyponatremia.

In case of an overdose, urgent gastric lavage is required, the patient is prescribed activated charcoal, hospitalization and therapy aimed at reducing symptomatic picture in a hospital setting.

Side effects

Side effects drug:

• Nervous system reaction - drowsiness, dizziness, headaches, tremors, paresthesias, taste disturbances, asthenia, ataxia, speech disorders, movement disorders eyeballs.
• On the part of the psyche - depression, auditory and visual hallucinations, anorexia, anxiety, enhanced psychosis.
• From the side skin- allergic dermatitis, erythroderma, itching, systemic lupus erythematosus, toxic epidermal necrolysis, acne, skin pigmentation disorders.
• From the side hematopoietic system- eosinophilia, thrombocytopenia, leukocytosis, leukopenia, lack of folic acid, anemia, pancytopenia, porphyria.
• Reaction gastrointestinal tract- attacks of nausea and vomiting, diarrhea, dry mouth, constipation, pancreatitis, stomatitis, glossitis, abdominal pain.
• From the side of the cardiovascular system - a decrease or increase in blood pressure, arrhythmia, bradycardia, collapse, thrombophlebitis, insufficiency.
• The reaction of the endocrine system is fluid retention, unreasonable weight gain, an increase in the concentration of prolactin, an increase in cholesterol levels.
• From the organs of the genitourinary system - hematuria, albuminuria, oliguria, azotemia, frequent urges to the toilet, kidney failure, nephritis, impaired spermatogenesis.

Taste disturbances, increased intraocular pressure, hearing disorders, muscle pain, arthralgia, convulsions, fever, shortness of breath.

Composition and pharmacokinetics

Composition of the drug - 1 tablet of the drug contains 200 mg of carbamazepine.

The composition also includes other substances: potato starch, magnesium stearate, talc, colloidal silicon dioxide, povidone, polysorbate.

The drug is absorbed slowly, but absorption is almost complete. The maximum concentration in blood plasma is observed after 12 hours, after one to two weeks of administration, we can talk about equilibrium concentrations. It is metabolized in the liver, excretion of the drug occurs in the form of inactive metabolites along with urine and feces. In children, it is excreted faster than in adults.

Other

Shelf life: the drug is valid for 3 years.

Storage conditions: must be stored in a dry and dark place out of the reach of children.

Terms of sale: by prescription.

Many people know that finlepsin and carbamazepine - similar preparations with the same active ingredient, but not many can say that finlepsin and carbamazepine are the same. In this article we will try to figure out which drug works better, talk about cheap and expensive analogues Finlepsin (carbamazepine), about its generics (generics).

Finlepsin has international name- carbamazepine.
Carbamazepine is a derivative of carboxamide and belongs to the group medicines used to treat epilepsy. Mainly used as anticonvulsant drug at large seizures(tonic-clonic epileptic seizures) and in focal psychomotor epilepsy. It has a normothymic (stabilizes mood in mentally ill people) action. It was discovered by a Swiss chemist in 1953 and was originally used exclusively for the treatment of trigeminal neuralgia. About antiepileptic properties learned much later.

Carbamazepine (Finlepsin) is included in the list of vital and essential drugs. In the anatomical and therapeutic classification, it is registered under code N03AF01.

What is the difference between Finlepsin and Carbamazepine

The main difference between Finlepsin and Carbamazepine from other manufacturers is that Finlepsin is a quality generic drug with proven bioequivalence to the original drug Tegretol. It is so much better than other generics that many consider Finlepsin original (although this is not true). The first carbamazepine that appeared on the market, in which a lot of studies were carried out to prove the effectiveness and safety - Tegretol. The remaining drugs with the active ingredient carbamazepine are generics (a copy made according to the "prescription" sold by the inventor's company). Generic carbamazepines are cheaper than the original, but, unfortunately, not always cheap means the best. From my experience, the experience of colleagues and the feedback of my patients, I will say that Finlepsin, although it is a copy of the original Tegretol, is much better than any generic carbamazepine. Finlepsin causes more pronounced anticonvulsant and analgesic effects. Significantly "softer" (these words describe his patients) side effects are tolerated.

Single generics, such as Finlepsin and Zeptol, can be equated in effectiveness with Tegretol.

Finlepsin drug - use and contraindications

The drug Finlepsin has found a wide application in modern medicine.
Here is a list of the conditions under which it is shown:

• various forms of epilepsy;
• neuralgia (especially often with trigeminal neuralgia);
• pain syndrome in diabetic neuropathy;
• renders good effect at vegetative crises(panic attacks);
• used in narcology for the treatment of alcohol dependence.

However, Finlepsin also has a large scroll contraindications, such as:

• individual intolerance, allergic reactions to carbamazepine or its derivatives;
• atrioventricular block;
• acute intermittent porphyria;
• bone marrow diseases;
• hypersensitivity to tricyclic antidepressants (Amitriptyline, Rimipramine, Imipramine, Clomipramine, Desipramine, etc.) and MAO inhibitors (Pirlindol, Tetrindol, Iprazide, Azilect, etc.).
• co-administration with voriconazole ( antifungal drug triazole groups).

Relative contraindications. Can be taken if the benefits far outweigh the risk of complications and side effects.

• Maximum caution should be exercised when treating people with finlepsin (carbamazepine) with liver and kidney disease;
• Myotonic dystrophy is not a direct contraindication, but requires great attention when selecting the dose and duration of treatment with carbamazepine;
• Finlepsin (carbamazepine) penetrates well into milk, therefore, if adverse reactions occur in a child, it is necessary to immediately stop breastfeeding;
• Children can be taken from 6 years;
• Pregnant women must take folic acid along with carbamazepine.

Finlepsin analogs of the best quality. Cheap analogues.

Very often, generic (generic) drugs are confused with similar ones, which sometimes causes strong controversy and problems.

Before writing a list of drugs similar to Finlepsin, I would like to clarify the concept of the original, similar and generic drug. This is necessary in order to avoid disputes and problems that arise due to confusion in the concept of generic (generic) and similar drug.

Original drug- this is a drug that did not exist before, it appeared on the market for the first time, has a patent and is presented by the developer. Before entering the pharmacy counters, the original drug goes through a lot of preclinical and clinical research tested for its effectiveness and safety. The original drug has a patent. The research period can take a long time. Therefore, in the end result, the original drug is distinguished not only by high quality and safety, but also by a high price relative to generic drugs.

Generic (generic) drug - a drug that is a reproduction of the original drug, whose patent protection has expired (in different countries the term of patent protection is different). The generic drug is produced under the international generic name(in this case is carbamazepine) or under a different name than the original. The generic drug did not pass all the studies, there were no development costs, so the price is much lower. However, some generic carbamazepines, which include Finlepsin, have proven to be bioequivalent to the original drug.

Wikipedia gives the following definition of bioequivalence:
Bioequivalence - the degree of similarity of a pharmaceutically equivalent drug in relation to the reference drug (usually a generic to the original patented drug).Pharmaceutical bioequivalence is also distinguished, which is considered as a complete reproduction of the composition and dosage form original medicinal product.

Therefore, Finlepsin is in no way inferior to the original drug, some doctors and pharmacists even consider Finlepsin to be an original drug. This is due to the fact that Tegretol is very difficult to get, and it costs very well.

Similar drug- a drug that differs in composition from the original. It has a different active ingredient, but has the same effect or a similar effect.

Tegretol Generics:

• Zeptol 200 and 400 mg tablets
• Carbamazepine Darnitsa, - Health, - Astropharm, - FS;
• Karbapin, tablets 200;
• Mezakar, tablets of 200 and 400 mg;
• Timonil, tablets of 150, 200, 300 and 600 mg;
• Finlepsin tablets 200 and 400 mg;
• Carbalex tablets 200, 300 and 600 mg.

Finlepsin analogs best quality:

Based on oxcarbazepine and eslicarbazepine acetate

• Exalief tablets 800 mg;
• Oksapin tablets 300 mg;
• Trileptal suspension 60 mg/ml, 250 ml vial;
• Trileptal tablets 300 and 600 mg №50.

Finlepsin analogues without a prescription with the active substance pregabalin

• Lyrica capsules of 150 and 300 mg;
• Linbag capsules 25, 50, 75, 150 and 300 mg;
• Zonic capsules 150 mg;
• Algerica capsules 75 and 150 mg;
• Gabalin capsules 75, 150 and 300 mg;
• Maxgalin capsules 75 and 150 mg;
• Neogabin capsules 75 and 150 mg;
• Pregabalin Pfizer capsules 150 mg;
• Pregabio capsules 25, 75, 100, 150, 200, 225, 300 mg;
• Pregadol capsules 150 and 300 mg;
• Pafia capsules 75 and 150 mg.

Finlepsin analogues without a prescription with the active ingredient gabapentin

• Gabagamma, capsules and tablets of 100, 200, 400, 600, 800 mg;
• Gabalept, capsules 300 and 400 mg;
• Gabantin, capsules of 100, 200 and 300 mg;
• Gabapentin 300mg capsules
• Gabastadin 100, 300 and 400 mg capsules;
• Meditan, capsules of 100, 300 and 400 mg;
• Grimodin, capsules of 100, 300 and 400 mg;
• Convalis, 300 mg capsules;
• Neuralgin, capsules of 300 and 400 mg;
• Neuropantin, 300 mg capsules;
• Nupintin 300 and 400 mg capsules;
• Eligan 100, 300 and 400 mg capsules.

Comparing two such well-known and quality drug like Tegretol and Finlepisin, it's very hard to say which is better. The only advantage of Tegretol is that it is original, while Finlepsin is generic. Although a very high-quality generic that has proven its therapeutic and pharmacological bioequivalence to the original drug. Finlepsin proved that in terms of efficiency it is not inferior to Tegretol, but it costs almost half as much. The same feedback from patients. If they do not respond very well to domestic carbamazepines, they say that the duration of action is much shorter, more often adverse reactions and complications. Tegretol and Finlepsin are referred to as two equal drugs.

Unfortunately, not everyone can afford to take original or high-quality generic drugs, far from all public procurement and state support include original preparations, so people sometimes have to be content with what they have ...

Carbamazepine - reviews for neuralgia

Initially, carbamazepine was used exclusively for the treatment of trigeminal neuralgia; antiepileptic and normothymic properties were learned much later. In my practice, I often use carbamazepine in combination to treat not only trigeminal neuralgia, but also to treat any kind of neuralgia and get mostly positive reviews from their patients. However, pharmacology does not stand still, discoveries are made of new, more advanced and modern drugs for the treatment of neuralgia and epilepsy. This and . The minus of new drugs is that they have not passed the test of time, like carbamazepine (it was discovered in 1953).

Carbamazepine and alcohol are not compatible! Carbamazepine enhances the effect of alcohol, so if you take carbamazepine and alcohol, you may experience severe intoxication with alcohol poisoning. The instructions strongly recommend not to drink alcohol during treatment. People who have mistakenly taken alcohol during treatment with carbamazepine say that even one bottle of beer (which equates to 20 to 50 ml of vodka) caused such Negative consequences like great intoxication with vomiting, headaches and dizziness.