Is Reduxin harmful to health? Reduxin. Reviews of doctors. Side effects. Which is better: Reduxin or Orsoten

drug for the treatment of obesity central action

Active ingredients

Sibutramine hydrochloride monohydrate (sibutramine)
- microcrystalline cellulose

Release form, composition and packaging

Capsules No. 2 blue. The contents of the capsules are white or white with a slightly yellowish tint powder.

The composition of the capsule shell: titanium dioxide - 2%, azorubine dye - 0.0041%, brilliant blue dye - 0.0441%, gelatin - up to 100%.

Capsules №2 of blue color. The contents of the capsules are white or white with a slightly yellowish tint powder.

Excipients: calcium stearate - 1.5 mg.

The composition of the capsule shell: titanium dioxide - 2%, patent blue dye - 0.2737%, gelatin - up to 100%.

10 pieces. - blister packs (aluminum/PVC) (3) - cardboard packs.
10 pieces. - cellular contour packings (aluminum/PVC) (6) - packs of cardboard.
10 pieces. - blister packs (aluminum/PVC) (9) - cardboard packs.

pharmachologic effect

Reduxin - combination drug, the action of which is due to its constituent components. Sibutramine is a prodrug and exerts its action in vivo due to metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (, norepinephrine and dopamine). An increase in the content of neurotransmitters in the synapses increases the activity of central serotonin 5HT- and adrenoreceptors, which contributes to an increase in the feeling of fullness and a decrease in the need for food, as well as an increase in thermal production. Indirectly activating β 3 -adrenergic receptors, sibutramine affects brown adipose tissue. Weight loss is accompanied by an increase in the concentration of HDL in the blood serum and a decrease in the amount of triglycerides, total cholesterol, LDL, uric acid.

Sibutramine and its metabolites do not affect the release of monoamines, do not inhibit MAO; have a low affinity for a large number neurotransmitter receptors, including serotonin receptors (5-HT 1 , 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C), adrenoreceptors (β 1 , β 2 , β 3 , α 1 , α 2) , dopamine (D 1 , D 2), muscarinic, histamine (H 1), benzodiazepine and glutamate (NMDA) receptors.

Microcrystalline cellulose is an enterosorbent, has sorption properties and a nonspecific detoxification effect. It binds and removes from the body various microorganisms, their metabolic products, toxins of exogenous and endogenous nature, xenobiotics, as well as an excess of some metabolic products and metabolites responsible for the development of endogenous toxicosis.

Pharmacokinetics

Absorption, distribution, metabolism

After taking the drug inside, sibutramine is rapidly absorbed from the gastrointestinal tract, not less than 77%. During the "primary passage" through the liver, it undergoes biotransformation under the influence of the CYP3A4 isoenzyme with the formation of two active metabolites (monodesmethylsibutramine (M1) and didesmethylsibutramine (M2)). After taking a single dose of 15 mg Cmax in the blood, M1 is 4 ng / ml (3.2-4.8 ng / ml), M2 is 6.4 ng / ml (5.6-7.2 ng / ml). Cmax is achieved after 1.2 hours (sibutramine), 3-4 hours (M1 and M2). Simultaneous food intake lowers Cmax of metabolites by 30% and increases the time to reach it by 3 hours without changing AUC. It is quickly distributed in tissues.

Protein binding is 97% (sibutramine) and 94% (M1 and M2). C ss of active metabolites in plasma is achieved within 4 days after the start of treatment and is approximately 2 times higher than the concentration in blood plasma after taking a single dose.

breeding

T 1/2 sibutramine - 1.1 h, monodesmethylsibutramine - 14 h, didesmethylsibutramine - 16 h. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted mainly by the kidneys.

Pharmacokinetics in special clinical situations

Currently available limited data do not indicate the existence of clinically significant differences in pharmacokinetics in men and women.

Pharmacokinetics in elderly healthy individuals ( average age 70 years) is similar to that of young people.

kidney failure does not affect the AUC of the active metabolites M1 and M2, except for the M2 metabolite in patients with terminal stage kidney failure on dialysis.

Liver failure. In patients with moderate liver failure after a single dose of sibutramine, the AUC of active metabolites M1 and M2 is 24% higher than in healthy individuals.

Indications

For weight loss with following states:

— alimentary obesity with a body mass index (BMI) of 30 kg/m2 or more;

- alimentary obesity with a BMI of 27 kg / m 2 or more in combination with diabetes 2 types and dyslipidemia.

Contraindications

- installed hypersensitivity to sibutramine or to other components of the drug;

- Availability organic causes obesity (eg, hypothyroidism);

— serious violations nutrition - anorexia nervosa or bulimia nervosa;

— mental illness;

- Gilles de la Tourette's syndrome (generalized tics);

- simultaneous administration of MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine,) or their use within 2 weeks before taking the drug Reduxin and 2 weeks after the end of taking other drugs that act on the central nervous system, inhibiting the reuptake of serotonin (for example, antidepressants , neuroleptics); sleeping pills containing tryptophan, as well as other centrally acting drugs for weight loss or for the treatment mental disorders;

— cardiovascular diseases(in history and at present): IHD (myocardial infarction, angina pectoris); chronic insufficiency in the stage of decompensation, occlusive diseases of peripheral arteries, tachycardia, arrhythmia, cerebrovascular diseases (stroke, transient disorders cerebral circulation);

- uncontrolled arterial hypertension (BP above 145/90 mm Hg) (see also section "Special Instructions");

- thyrotoxicosis;

— severe violations liver function;

- severe renal dysfunction;

— benign hyperplasia prostate;

- pheochromocytoma;

- angle-closure glaucoma;

- established pharmacological, narcotic or alcohol addiction;

- pregnancy;

- period breastfeeding;

- children's and adolescence up to 18 years;

— elderly age over 65 years old.

FROM caution the drug should be prescribed under the following conditions: arrhythmias in history, chronic circulatory failure, diseases coronary arteries(including history), except for coronary artery disease (myocardial infarction, angina pectoris); glaucoma, except for angle-closure glaucoma, cholelithiasis, arterial hypertension (controlled and history), neurological disorders, including mental retardation and seizures (including history), epilepsy, impaired liver function and / or kidney light and medium degree severity, history of motor and verbal tics, bleeding tendency, bleeding disorders, taking drugs that affect hemostasis or platelet function.

Dosage

Reduxin is prescribed orally 1 time / day. The dose is set individually, depending on tolerability and clinical efficacy.

Capsules should be taken in the morning without chewing and drinking enough liquids (a glass of water). The drug can be taken on an empty stomach or combined with food intake.

If within 4 weeks from the start of treatment a decrease in body weight of less than 2 kg is not achieved, then the dose is increased to 15 mg / day. Treatment with Reduxin should not be continued for more than 3 months in patients who do not respond well enough to therapy, i.e. who within 3 months of treatment fail to achieve a weight loss of 5% of the baseline. Treatment should not be continued if, during further therapy, after the achieved weight loss, the patient again gains 3 kg or more in body weight. The duration of treatment should not exceed 1 year, since there are no data on efficacy and safety for a longer period of taking sibutramine.

Treatment with Reduxin should be carried out in combination with diet and exercise under the supervision of a physician with practical experience in the treatment of obesity.

Side effects

Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency weaken over time. Side effects are generally mild and reversible.

Side effects, depending on the impact on organs and organ systems, are presented in the following order: very often (> 10%), often (≥ 1%, but ≤ 10%).

From the side of the central nervous system: very often - dry mouth, insomnia; often - headache, dizziness, anxiety, paresthesia, taste changes.

often - tachycardia, palpitations, increased blood pressure, vasodilation.

There is a moderate rise in blood pressure at rest by 1-3 mm Hg. and a moderate increase in heart rate by 3-7 bpm. In some cases, more pronounced increases in blood pressure and heart rate are not excluded. Clinically significant changes in blood pressure and pulse are recorded mainly at the beginning of treatment (in the first 4-8 weeks). The use of the drug Reduxin in patients with elevated blood pressure: see the section "Contraindications" and "Special Instructions".

very often - loss of appetite, constipation; often - nausea, exacerbation of hemorrhoids. With a tendency to constipation in the early days, it is necessary to control the evacuation function of the intestine. If constipation occurs, stop taking the drug and take a laxative.

From the side of the skin: often - increased sweating.

In isolated cases, the following clinically significant adverse events have been described during treatment with sibutramine: dysmenorrhea, edema, flu-like syndrome, skin itching, back pain, abdominal pain, paradoxical increase in appetite, thirst, rhinitis, depression, drowsiness, emotional lability, anxiety, irritability, nervousness, acute interstitial nephritis, bleeding, Shenlein-Genoch purpura, convulsions, thrombocytopenia, transient increase in liver enzymes in the blood.

During post-marketing research additional adverse reactions listed below by organ system.

From the side of cardio-vascular system: flickering arrhythmia.

From the immune system: hypersensitivity reactions (ranging from mild skin rashes and urticaria to angioedema(angioedema) and anaphylaxis).

Mental disorders: psychosis, states of suicidal thinking, suicide and mania. When similar states the drug must be discontinued.

From the nervous system: convulsions, short-term disturbances memory.

From the side of the organ of vision: blurred vision ("veil before the eyes").

From the digestive system: diarrhea, vomiting.

From the skin and subcutaneous tissue: alopecia.

From the urinary system: urinary retention.

From the reproductive system: ejaculation/orgasm disorders, impotence, impaired menstrual cycle, uterine bleeding.

Overdose

There are extremely limited data on overdose of sibutramine. In case of overdose, the patient should consult a doctor.

Symptoms: most often - tachycardia, increased blood pressure, headache, dizziness. You should notify your doctor in case of suspected overdose.

Treatment: special treatment and there are no specific antidotes. Needs to be done general activities: provide, monitor the state of the cardiovascular system, and, if necessary, implement supportive symptomatic therapy. Timely application activated carbon, as well as gastric lavage can reduce the intake of sibutramine in the body. Patients with high blood pressure and tachycardia can be prescribed beta-blockers. The effectiveness of forced diuresis or hemodialysis has not been established.

drug interaction

Inhibitors of microsomal oxidation, incl. inhibitors of the CYP3A4 isoenzyme (ketoconazole, erythromycin, cyclosporine and others) increase plasma concentrations of sibutramine metabolites with an increase in heart rate and a clinically insignificant increase in the QT interval.

Rifampicin, macrolide antibiotics, phenytoin, carbamazepine, phenobarbital and dexamethasone can accelerate the metabolism of sibutramine.

The simultaneous use of several drugs that increase the content of serotonin in the blood can lead to the development of a serious interaction. The so-called serotonin syndrome can develop in rare cases with the simultaneous use of the drug Reduxin with selective serotonin reuptake inhibitors (drugs for the treatment of depression), some drugs for the treatment of migraine (sumatriptan, dihydroergotamine), potent analgesics (pentazocine, pethidine, fentanyl) or antitussive drugs (dextromethorphan).

Sibutramine does not affect the effect of oral contraceptives.

At simultaneous reception sibutramine and ethanol, there was no increase in the negative effect of ethanol. However, the use of alcohol is absolutely not combined with the dietary measures recommended when taking sibutramine.

With simultaneous use with sibutramine of other drugs that affect hemostasis or platelet function, the risk of bleeding increases.

Drug interactions with the simultaneous use of sibutramine with drugs that increase blood pressure and heart rate are currently not fully understood. This group of drugs includes decongestants, antitussives, colds and antiallergic drugs, which include ephedrine or pseudoephedrine. Therefore, in cases of simultaneous administration of these drugs with sibutramine, caution should be exercised.

The concomitant use of sibutramine with CNS-acting weight-loss drugs or psychiatric drugs is contraindicated.

special instructions

Reduxin should be used only in cases where all non-drug measures to reduce body weight are ineffective - if the weight loss for 3 months was less than 5 kg.

Treatment with Reduxin should be carried out within the framework of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity.

Comprehensive therapy for obesity includes both diet and lifestyle changes and increased physical activity. An important component therapy is to create the prerequisites for lasting change eating behavior and lifestyle, which are necessary to maintain the achieved weight loss and after withdrawal drug therapy. As part of Reduxin therapy, patients need to change their lifestyle and habits in such a way that, after completion of treatment, the achieved weight loss is maintained. Patients should clearly understand that failure to comply with these requirements will lead to a repeated increase in body weight and repeated visits to the attending physician.

In patients taking Reduxin, it is necessary to measure blood pressure and heart rate. In the first 3 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. If an increase in resting heart rate ≥10 bpm or systolic/diastolic pressure ≥10 mmHg is detected during two consecutive visits, treatment should be discontinued. In patients with arterial hypertension, which have on the background antihypertensive therapy Blood pressure above 145/90 mm Hg, this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg during repeated measurement. treatment with Reduxin should be discontinued.

In patients with sleep apnea, blood pressure should be carefully monitored.

Particular attention should be paid to the simultaneous administration of drugs that increase the QT interval. These drugs include blockers of histamine H 1 receptors (astemizole, terfenadine); antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol); gastrointestinal motility stimulant (cisapride), pimozide, sertindole and tricyclic antidepressants. This also applies to conditions that can lead to an increase in the QT interval, such as hypokalemia and hypomagnesemia (see also the section "Drug Interactions").

The interval between taking MAO inhibitors (including furazolidone, procarbazine, selegiline) and Reduxin should be at least 2 weeks.

Although a relationship has not been established between taking the drug Reduxin and the development of primary pulmonary hypertension not established, however, given the well-known risk of drugs in this group, with regular medical monitoring, it is necessary Special attention address symptoms such as progressive dyspnea (breathing disorder), pain in chest and swelling in the legs.

If you miss a dose of the drug Reduxin, you should not take a double dose of the drug in the next dose, it is recommended to continue further taking the drug according to the prescribed scheme.

The duration of taking the drug Reduxin should not exceed 1 year.

When sibutramine is co-administered with other serotonin reuptake inhibitors, there is increased risk bleeding development. In patients predisposed to bleeding, as well as taking drugs that affect hemostasis or platelet function, sibutramine should be used with caution.

Although there are no clinical data on addiction to sibutramine, it should be clarified if there were any cases in the patient's history drug addiction and pay attention to possible signs of drug abuse.

Influence on the ability to manage vehicles and mechanisms

Taking the drug Reduxin may limit the ability to drive vehicles and mechanisms. During the period of use of the drug Reduxin, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Pregnancy and lactation

Since there are not enough studies to date regarding the safety of sibutramine exposure to the fetus, this drug contraindicated during pregnancy.

Women who are in reproductive age, while taking the drug Reduxin should use contraceptives.

It is contraindicated to take Reduxin during breastfeeding.

Use in the elderly

Contraindicated in the elderly over 65 years.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 25 ° C. Shelf life - 3 years.

Now many girls are trying to lose weight with the help of not only diets, but also drugs designed to reduce weight. One of these is Reduxin, which promotes rapid fat burning.

Is it possible to lose weight with Reduxin tablets ^

Reduxin is a drug designed specifically for obese people with or without diabetes. It makes it easy to follow any diet, because. has all the necessary functions for this.

The main properties of Reduxin for weight loss are expressed as follows:

• Accelerates and prolongs the feeling of fullness;
• Lets get rid of increased appetite;
• Stimulates metabolism, as a result of which fat cells are broken down more intensively.

Composition and form of release

Reduxin contains sibutramine, which is the main active ingredient. In addition to it, calcium stearate, gelatin and dyes can be found in it. What are the release forms?

• Capsules 10 mg, 30 and 60 pcs.
• Capsules 15 mg, 30 and 60 pcs.

It is enough to take Reduxin capsules, and weight loss will not be long in coming, because the drug acts very quickly, and its effect becomes noticeable in the first week.

Reduksin and Reduksin Light: what is the difference

Do not confuse the usual Reduksin and weight loss on Reduksin Light:

• In the first case, the drug is prescribed by a doctor and should be used with extreme caution;
• And the "lite" version is just biologically active additive, and weight loss is not as effective.

Pros and cons

Reception of Reduksin when losing weight has a number of positive aspects:

• Despite some side effects, severe complications appear extremely rarely. The only thing that may bother you at first is nervousness, dry mouth and insomnia;
• It helps to learn to control your appetite and get rid of overeating;
• For a month on it you can throw off a significant part excess weight.

As for the side effects, there are a lot of them:

• insomnia, dry mouth, headache;
• Dizziness, tachycardia;
• Constipation, exacerbation of hemorrhoids;
• Nausea;
• Complete loss of appetite;
• Increased sweat separation;
• Alopecia;
• Urinary retention.

Instructions for use

• At the very beginning of the reception daily rate Reduxin should not exceed 10 mg.
• With the appearance of mild side effects - 5 mg.
• If in 4 weeks it was possible to throw off less than 2 kg, then the dosage can be increased to 15 mg.

How to take:

• In the morning on an empty stomach or during meals, drink 1 capsule of 200 g of water;
• The minimum duration of treatment is 3 months, however, if during the use of the capsules after the result is achieved, the weight begins to increase, the course should be stopped.

Generally, safe dosage Reduxine for weight loss is 15 mg per day, but the reception this medicine must be combined with a low-calorie diet:

• Refuse sweets, fatty and fried foods.
• You should include more fruits and vegetables in your diet.
• Use sour-milk low-fat drinks, fish, berries and meat in your diet.

Indications for the use of Reduxin

This drug is used exclusively for the treatment of obesity in two cases:

• If the body mass index exceeds 30 kg / m 2;
• With alimentary obesity with a BMI of 27 kg / m 2 and type 2 diabetes mellitus, or dyslipidemia.

Contraindications

The list of diseases in which the drug is contraindicated is quite extensive.:

• Eating disorders (bulimia or anorexia);
• Allergy to the components of the drug;
• Hypothyroidism;
• mental illness;
• Disorders of the kidneys or liver;
• Diseases of the heart and blood vessels;
• thyrotoxicosis;
• Pregnancy and breastfeeding;
• Adolescence or old age after 65 years;
• Hypertension.

Reception of MAO inhibitors must be completed 2 weeks before the start treatment course with Reduksin, and in the future it can be resumed only 14 days after its completion.

Reviews of doctors and those who have lost weight, results ^

According to doctors, any drug negatively affects health, besides, with a large list of side effects, in some cases it is necessary to stop the course, however, the results of losing weight with the help of Reduxin Light enhanced formula still have a positive effect on the figure:

• Weight decreases by an average of 5-8 kg per month;
• Manages to avoid overeating.

Independent use of Reduxin is undesirable, because. it should be taken only on the recommendation of a nutritionist, who calculates the optimal dosage and duration of treatment.

Experience of our readers

Yana, 28 years old:

“I drank these capsules for 4 months, and they really helped - I lost 15 kg. For the first two weeks, I had a terrible dry mouth, especially in the morning, but then everything went away. I combined the treatment with - perhaps that is why the result was quite good "

Margarita, 34 years old:

“To remove 30 kg of excess weight, the doctor prescribed Reduxin for me. There is only one good thing about him - he really helped me lose so many kilograms in six months. There are many minuses: I became irritable, I sleep badly, I sweat a lot. Before drinking it, you should definitely consult a doctor: it may be possible to do without such drastic measures.

Olesya, 43 years old:

“I drank Reduxin for almost a year, and did not notice any negative effect. I felt good all the time, besides, the weight was melting at an enviable rate: during this time I lost about 30 kg, and now I’m slim again!

Eastern horoscope for March 2019

It is known that in recent decades, everything has been suffering from obesity. most of the population of the earth. It's no secret to anyone that it's not even about aesthetic flaws, but rather in potential get very serious illnesses such as hypertension, coronary heart disease, myocardial infarction, type 2 diabetes mellitus, infertility and so on.

Everyone who has ever decided to go to the fight against the notorious kilograms knows how difficult it is: exhausting diets, hard physical exertion, rejection of your favorite food, limiting yourself in almost everything. People are ready to lose weight by any means, just to quickly get rid of fat, which is why many people who want to lose weight are looking for new ways to lose weight. It's about acceptance. medicines. Various drugs are used in the treatment of obesity. But he is best known for his combined action reduxin.

About the drug

Reduksin (REDUKSIN) - domestic drug to reduce body weight, the main active ingredient of which is sibutramine, potent substance complex effect on the body.

Its first and main effect is to provide an anorexigenic effect, which is based on blocking the reuptake of neurotransmitters in the synapses of the brain, resulting in a feeling of fullness much earlier than usual.

The second effect is related to the stimulation of metabolism. In this case, the body begins to experience a greater need for energy, the consumption of which begins to increase. All this leads to the fact that the assimilation of food and the use of nutrients contained in food is performed much more actively.

Reviews of doctors

After examining and monitoring patients who took Reduxin, the doctors' reviews can be reduced to the following data:

• 98.5% of patients showed a marked decrease in appetite;
• the portions eaten and the patient's usual daily calorie intake are significantly reduced. On average, 2 - 2.5 times;
• in the process of taking the drug in losing weight, the correct eating behavior is formed;
• this drug for weight loss gives the most stable results, which patients manage to keep for a long time;
• In general, sibutramine is well tolerated by patients and is not addictive.

Thanks to all this, rapid decline weight. The patient is visibly motivated.

Vladimir Larionov, nutritionist

I know from practice that Reduxin is a great help in the treatment of obesity, when folk remedies for weight loss already bring good effect incapable. At the same time, after reading only the most general feedback, some women, and often men, begin to drink it on their own. After that, they get serious side effects. I can recommend this drug for the fight against obesity. But only on condition that a doctor is constantly involved in this process.
To achieve a lasting effect, taking the drug should last at least three months, and it is advisable to combine its use with moderate physical activity and a balanced diet. diet food.

Positive effects of taking Reduxin

In general, reduxin has established itself as one of the the best drugs for the treatment of obesity and weight loss, and there is a feeling that humanity has invented universal pills for obesity, taking which, you can permanently get rid of terrible problems.

Reviews of doctors allow us to mark it as the best drug, the intake of which does not depend on food intake. This is very convenient when you can take just 1 tablet a day without adjusting to the need to eat something.

What side effects can reduxin cause?

But like any pharmaceutical drug, reduxin has a number of side effects:

• headache;
• appetite changes;
• constipation;
• heartburn;
• dry mouth;
• weakness;
• backache;
• nervousness;
• difficulty falling asleep or not sleeping soundly;
• runny nose;
• flu symptoms.

Some side effects may be serious. The following symptoms are not typical, but if any of them are present, you should immediately consult a doctor: palpitations, chest pain, difficulty breathing, nausea, intense pain in the stomach, vomiting, euphoria, anxiety, anxiety, depression, dizziness, loss of consciousness, confusion, uncoordinated or abnormal movements, muscle rigidity, uncontrollable hand tremors, seizures, tremors, excessive sweating, fever, sore throat, dilated pupils, vision changes, eye pain, rash, skin redness, itching, difficulty speaking , breathing or swallowing, hoarseness, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles.

In addition, reduxin is not compatible with most medicines, He gives increased load on the liver, and can even cause poisoning with conventional flu powders containing paracetamol. Remember that self-administration of strong drugs for weight loss can be hazardous to your health. Therefore, a competent doctor should prescribe reduxin, after carrying out special diagnostic measures.

The choice of weight loss products is constantly growing, while only a few drugs are allowed. According to reviews, if you take Reduxin diet pills, you can effectively fight obesity, while there are many analogues of this medication that greatly outweigh it in price. A sibutramine-based remedy suppresses appetite, but in order to lose weight with it overweight, must be adhered to balanced diet and actively engage in sports.

What is Reduxin

The weight loss drug Reduxin contains sibutramine, an active substance that ensures gradual weight loss. However, the tool can only have a serious effect if combined with other methods of combating obesity. So, taking the drug Reduxin for weight loss, you should reduce the caloric content of the diet, giving preference to healthy food, drink a lot clean water and exercise regularly.

These tablets contain toxic substance, therefore, are dispensed by prescription. It is advisable to use them only with significant weight problems: the medicine is forbidden to be taken if there are only a few extra pounds. An indication for the start of treatment with Reduxin is the presence of excess body weight of 30 kg or more.

Compound

The release form of the product is blue capsules of 10 and 15 mg (the difference is in the content of the active ingredient). The composition of Reduxin includes such substances:

1. Sibutramine. The component suppresses the feeling of hunger, due to which a person reduces the amount of food consumed and gradually loses weight. This substance is the only one that is allowed to be used in the manufacture of anti-obesity drugs, therefore, in many weight loss drugs, sibutramine is used as the basis. It acts on the center of hunger, thereby providing a phantom feeling of satiety.
2. Microcrystalline cellulose. This component also stimulates the feeling of satiety. When it enters the stomach, cellulose swells, absorbing harmful substances and water, fills the volume of the organ, preventing the losing weight from eating a lot.

How Reduxin works

Anti-obesity pills Reduxin have an effect directly on nervous system a person, therefore, the remedy is dispensed solely on the prescription of a doctor. The action of Reduxin is aimed at suppressing the feeling of hunger, reducing appetite. Due to this, losing weight reduces the number of snacks and the total amount of food consumed is reduced. Due to the effect of thermogenesis, energy consumption increases and calories are burned faster. In addition, the metabolism is accelerated, the level of glucose, cholesterol and lipids in the blood is normalized.

The described mechanism of action of Reduxin diet pills allows a person to effectively lose weight, while weight reduction occurs at a safe rate (about 1 kg per week). However, taking anti-obesity medication can cause Negative consequences in the form of side effects, so the treatment should be under the close supervision of a doctor.

Reviews of doctors

The opinion of nutritionists and other doctors regarding the advisability of taking diet pills was divided. At the same time, most doctors are of the opinion that taking the medication should be a necessary measure: the use of the drug is possible only if other methods have not helped to get rid of excess body weight. Losing weight with Reduxin can cause serious harm to human health, causing problems with the heart, blood vessels, digestive system, etc.

Reviews of doctors about Reduxin are contradictory, but all experts agree that treatment with this remedy should be carried out under the supervision of a doctor. In addition, a person who decides to lose weight with this medication should have good health(any pathology is a contraindication for the use of Reduxin). Before you start drinking pills, it is recommended to be examined by a cardiologist.

Reduksin's instruction

The duration of taking diet pills should not exceed two years, as more long-term use products with sibutramine can lead to negative consequences. It is important to avoid overdose, as this will increase the severity of side effects and necessitate gastric lavage and symptomatic treatment. Therapy with Reduxin diet pills, according to the instructions, is carried out under the supervision of the attending physician.

How to take Reduxin 15 mg

If a month has passed since the start of treatment for obesity with pills, and body weight has not decreased even by a couple of kilograms, the initial dosage of 10 mg is increased to 15 mg. The dose should be drunk at a time. Reduxin 15 mg should be taken for at least 3 months or longer, otherwise tangible effect will not. With such daily dosage the maximum course of treatment is a year. Doctors recommend combining diet pills with physical activities and diet.

How to take Reduxin 10 mg

The doctor independently selects the dosage for each patient, but, as a rule, they start taking Reduxin 10 mg. If a person has problems with blood clotting or low compatibility of the drug with individual indicators of the body, then daily dose reduced to 5 mg. Wash down the tablets with a large volume of liquid, since the product has the ability to swell, like fiber. It is advisable to drink the capsules during a meal.

How to take Reduxin Light

This form the drug is prescribed for people who are prone to weight gain, but want to keep it or intend to lose a couple of extra pounds. Reduxin Light should be taken twice a day - before or after meals. You can increase the effectiveness of capsules by performing sports exercises and compliance light diet. If necessary, a monthly course of weight loss with the help of Reduksin is repeated after 2-3 months.

Analogues

Available for sale different drugs with monohydrate hydrochloride in the composition, while each of them uses different dosage substances. Before giving any diet pills your preference, consult your doctor. Demanded analogues of Reduksin are:

• Lindax (has a similar effect to Reduxin on the brain, but can cause anorexia nervosa and have more high cost);
• Goldline (produced in the same dosage as Reduxin, has a relatively low price and is suitable for the treatment of people with severe obesity);
• Meridia (the price of Reduxin is more favorable, in addition, this drug is prohibited for sale in Russia and European countries);
• Slimia (sold exclusively in India, has a composition similar to the tablets described above);
• Reduxin-Met (cheap drug, originally intended for therapy endocrine pathologies, which led to obesity, is also prescribed for people with type 2 diabetes or dyslipidemia).

Contraindications

Reduxin diet pills can be used by people with kidney failure and those on dialysis. It is forbidden to use the product in case of individual intolerance to its active substances. In addition, people whose obesity is due to the presence of hypothyroidism should refrain from taking capsules. Other contraindications of Reduxin:

• mental illness (including bulimia, anorexia);
• early age(up to 18 years old);
• pregnancy, lactation;
• generalized tics;
• taking MAO inhibitors;
• the use of drugs that affect the central nervous system;
• reception sleeping pills based on tryptophan;
• the use of other drugs for weight loss;
• tachycardia;
• thyrotoxicosis;
• heart failure, congenital organ defects;
• arrhythmia;
• pathology of the arteries;
• stroke, circulatory disorders;
• serious disorders in the liver;
• hypertension;
• angle-closure glaucoma;
• benign prostatic hyperplasia;
• age after 65 years;
• pheochromocytoma;
• addiction (drug/alcohol/drug).

Side effects

Negative Effects caused by the start of taking the capsules, as a rule, disappear during the month of treatment or their intensity decreases. Frequent side effects of Reduxin are sleep disturbances (insomnia or drowsiness) and dry mouth. In addition, a person may experience dizziness, develop depression. Other possible negative effects of taking capsules:

• causeless anxiety;
• symptoms of tachycardia;
• increase in blood pressure;
• hormonal disorders;
• dysmenorrhea;
• constipation, diarrhea;
• pruritus;
• paresthesia;
• loss of appetite;
• sweating;
• a decrease in the protective properties of the body and, as a result, more frequent respiratory diseases;
• mental anomalies;
• angioedema.

Price for Reduksin

The only option where to buy high quality Reduxin is in a pharmacy in any major city. It is not worth buying any Chinese or Indian drug substitutes, since these drugs do not have a fixed dosage of sibutramine and their use can end in failure. How much does Reduxin cost? At official points of sale, capsules have a fixed price; there are no promotions or discounts for such medicines. The price of Reduksin varies depending on the city and pricing policy entrepreneur: you can buy a product in Moscow for 1500-2000 rubles.

Video: how Reduxin works on the body

As well as microcrystalline cellulose .

As an additional substance in the composition of the drug contains calcium stearate.

The capsule shell consists of gelatin, azorubine dye, titanium dioxide dye, patented blue dye.

Release form

The drug is available in the form of capsules of 10 mg and 15 mg.

Capsules 10 mg have a blue color, inside contains a white or white-yellow powder. Contained in blister packs, which are packed in cardboard packs. In such a pack there can be 30 or 60 capsules.

Reduxin 15 mg- these are blue capsules, inside the capsules there is a white or white-yellow powder. Contained in blister packs, which are packed in cardboard packs. In such a pack there may be 30 or 60 capsules.

pharmachologic effect

Wikipedia indicates that Reduxin is combined remedy used for the treatment . The way a drug works determines its composition.

Sibutramine is a prodrug that acts in the body at the expense of metabolites (primary and secondary amines). Metabolites inhibit reuptake monoamines (mainly and serotonin ). Due to the increase in the content of neurotransmitters in the synapses, the activity of adrenoreceptors and central serotonin 5-HT receptors increases. As a result, the patient's feeling of fullness increases, the need for food decreases. Also, under the influence of the drug, thermal production increases. There is an effect on brown adipose tissue due to mediated activation of β3-adrenergic receptors.

In parallel with a decrease in a person's weight, an increase in the concentration of HDL in the blood serum is noted. There is also a decline in overall , the amount of triglycerides, uric acid.

Microcrystalline cellulose is an enterosorbent that demonstrates a non-specific detoxification effect and sorption properties. This substance binds microorganisms, xenobiotics , allergens , toxins and removes them from the body.

Pharmacokinetics and pharmacodynamics

After the drug is ingested, sibutramine rapidly absorbed from the gastrointestinal tract. Absorption is at least 77%. Sibutramine is biotransformed, resulting in the formation of two active metabolites (mono- and didesmethylsibutramine). The highest concentration of the substance in the body is observed 1.2 hours after ingestion. The highest concentration of metabolites - after 3-4 hours.

If Reduxin tablets were taken simultaneously with food, then the maximum concentration of metabolites is reduced by 30%, and the period of its achievement is also increased by three hours. Distributes quickly into tissues. Sibutramine binds to blood proteins by 97%, and metabolites - by 94%. It is excreted mainly by the kidneys, the half-life of sibutramine is 1.1 hours, metabolites - 14-16 hours.

Indications for use

The abstract indicates that Reduxin is used to reduce body weight. Like other weight loss products, it is indicated for people who suffer from alimentary obesity and their body mass index is 30 kg/m2 or more. It is also prescribed for people who are diagnosed with alimentary obesity with a BMI of 27 kg / m2 and at the same time there are other risk factors associated with overweight (dyslipoproteinemia , diabetes ).

Contraindications for Reduxin

Before you start taking the remedy, you should definitely take into account contraindications and side effects. Reduxin is contraindicated in the following cases:

• organic causes of obesity (etc.);
• mental illness;
• eating disorders ( bulimia nervosa , anorexia nervosa );
• Tourette's syndrome;
• severe diseases of the heart and blood vessels (heart failure, congenital heart defects, ischemic heart disease, , peripheral arterial disease, etc.);
• cerebrovascular disease (cerebrovascular disease, );
• arterial hypertension uncontrolled;
• severe impairment of kidney and liver function;
• pheochromocytoma ;
• closed-angle ;
• prostate hyperplasia benign;
• alcohol, drug or drug addiction;
• pregnancy and lactation;
• age up to 18 years and after 65 years;
• high sensitivity to the components of the drug;
• simultaneous treatment with MAO inhibitors or the use of such drugs for two weeks before the use of Reduxin;
• the simultaneous use of drugs that have an effect on the central nervous system.

The description of the drug also contains information about the conditions under which Reduxin should be taken with caution. This is circulatory failure chronic form, arrhythmias history of coronary artery disease, cholelithiasis , neurological disorders, arterial hypertension (in history), mild and moderate violations of the functions of the kidneys and liver, motor and verbal tics.

Side effects of Reduxin

When taking capsules 10 mg and 15 mg, the following side effects may occur:

• nervous system: , dry mouth, , headache , paresthesia, anxiety, drowsiness; in rare cases - , nervousness , cramps, back pain, irritability ;
• the cardiovascular system: heartbeat, , increased blood pressure, vasodilation;
• digestive system: , appetite changes , nausea , exacerbation ;
• dermatological manifestations: sweating, itching of the skin, Henoch-Schonlein purpura;
• manifestations of the body as a whole: in rare cases - edema, dysmenorrhea , flu-like syndrome , rhinitis , thirst , nephritis , thrombocytopenia , bleeding.

When canceled, a negative effect on the body is rarely noted. Possible manifestation of increased appetite, headache. There are no data on the manifestations of the withdrawal syndrome.

The manifestation of side effects is most often observed in the first days or weeks of taking the tablets. Negative manifestations are generally weakly expressed, with time they weaken.

Capsules Reduksin, instructions for use (Method and dosage)

Instructions for the use of Reduxin provide that the doctor prescribes the medicine individually, taking into account its composition and the patient's condition. You need to take the tablets once a day. The capsule should not be chewed, it is important to drink it down large quantity water. You can drink drugs before meals or during. As the instructions for Reduxin testify, 10 mg is the initial dose of the drug. If the patient does not tolerate the drug well, the dose can be reduced to 5 mg.

In the event that a patient has reduced body weight by 5% or more within four weeks, then daily dose increase to 15 mg. In those patients who do not respond well to treatment, that is, the weight has not decreased by more than 5%, treatment should not continue for more than three months. Also, treatment should not be continued if the patient has regained more than 3 kg after the achieved weight change.

With normal tolerability, the capsules should not be continued for more than two years. The manufacturer provides instructions describing the drug and how to drink to lose weight.

How to take it correctly in order to lose weight, a specialist can tell in detail. The dosage and duration of treatment is prescribed by a doctor who has experience in the treatment of obesity. The medicine must be combined with diet and exercise.

Overdose

Sufficient data on the overdose of sibutramine are currently not available. In case of an overdose, it is important to immediately contact a specialist. If you take too much of the drug, side effects may increase. No information about specific features overdose.

When you receive excessive doses funds need to be taken, gastric lavage. Held symptomatic treatment. If, after an overdose, the patient's blood pressure rises or tachycardia is noted, it is advisable to prescribe beta-blockers.

Interaction

If Reduxin is combined with inhibitors of microsomal oxidation (including inhibitors of cytochrome P450 isoenzyme 3A4), there is an increase in the concentration of sibutramine metabolites in plasma with an increase in heart rate and an increase in the QT interval, which is clinically insignificant.

A number of drugs can accelerate the metabolism of sibutramine: macrolide antibiotics, , , , .

It should be noted that when taking several drugs that increase blood levels of serotonin at the same time, a serious interaction can develop.

In rare cases, the development of serotonin syndrome is possible if Reduxin and selective reuptake inhibitors are taken simultaneously. , a number of drugs for the treatment of migraine, antitussive drugs, potent analgesics.

No exposure to oral contraceptives does not affect.

Terms of sale

Patients who are interested in whether Reduxin is sold by prescription or not should be aware that drugs can only be bought by prescription. A sample recipe can be found on specialized sites.

Storage conditions

Store the capsules in a dry place, the temperature should not exceed 25°C.

Best before date

Capsules are stored for 3 years.

special instructions

You can take 10 mg or 15 mg Reduxin capsules only if all other methods aimed at weight loss are ineffective, that is, if over 3 months the weight has decreased by less than 5 kg.

Any drugs for weight loss, including Reduxin, should be taken in combination with other measures aimed at reducing body weight. In this case, the supervision of an experienced doctor is important.

As evidenced by the official website of the drug, the composition of complex therapy includes a change in the principles of nutrition and lifestyle, as well as enhanced physical activity. It is important to recognize the need to change habits in order to maintain achieved result. For those who do not follow these rules, the question may subsequently arise why any drug does not help to lose weight.

The doctor should advise the patient not only on how to properly lose weight with Reduxin, but also talk about the need to regularly measure the pulse and arterial pressure. These indicators need to be monitored every two weeks at first. Especially careful should be the control of blood pressure in people with arterial hypertension. It is important to suspend treatment if, during the control process, pressure exceeding 145/90 mm Hg was noted twice in a row. st

Be especially careful when taking medications that increase QT interval . These are drugs against arrhythmias that increase the QT interval, as well as blockers histamine H1 receptors , stimulants of gastrointestinal motility.

To date, there is no accurate data on the relationship of treatment with this agent and the manifestation in the patient primary pulmonary hypertension . But in the process of treatment, it is important to pay special attention to the manifestation of chest pain, swelling in the legs and progressive dyspnea.

It is important to consider that when taking a medicine, a person's ability to drive vehicles and control other mechanisms may be limited.

What is the difference between Reduxin and Reduxin Light?

When choosing a drug, patients often ask the question: which is better - Reduxin or Reduxin Light . You should immediately take into account the differences in the composition of these funds. The instruction indicates that Reduxin Light is an additive that contains conjugated linoleic acid, and additional substances. Active ingredients funds contribute to the normalization of metabolism, activate the processing of fat. However, Reduxin Light is most appropriate to use with an active lifestyle and constant physical activity. The price, in comparison with LS Reduksin, is slightly lower. The drug Reduxin has a different mechanism of action. Therefore, in each individual case, the doctor individually determines what is more effective and what is better to prescribe to the patient. Discussing Reduxin and Reduxin Light, patients leave diverse reviews, from positive to less enthusiastic.

Which is better: Goldline or Reduxin?

When comparing the two drugs, it should be noted that active substance Goldline also contains sibutramine. The product is available in capsules. Which of the drugs is appropriate to use, the doctor must determine.

Which is better: Reduxin or Orsoten?

It is an inhibitor of intestinal enzymes. By reducing the activity of gastric and intestinal lipases, it reduces the intake of calories and thus promotes weight loss. Reduxin acts differently, so the choice of the drug should be carried out only by a doctor, guided by individual characteristics patient.

Which is better: Reduxin or Xenical?

also acts by suppressing gastrointestinal lipases. Active substance of this drug. Since both drugs act differently in the body, the final choice should be made by a specialist.

Lindax or Reduxin - which is better?

As part of the drug Lindax also has the active ingredient sibutramine. Its mechanism of action is similar to Reduxin. However, now the supply of the drug is limited, so it can only be ordered by mail or bought on the “for sale” ad.

Which is better: Reduxin or Turboslim?

As part of the tool contains plant extracts that stimulate the process of losing weight. This tool is active biological additive and is used on the advice of a doctor.

children

The drug is contraindicated in patients under 18 years of age.

Reduxin and alcohol

Discussing Reduxin's compatibility with alcohol, it should be noted that when taking capsules and alcohol together negative impact ethanol on the body is not marked. But since the treatment with this remedy requires a diet, doctors strongly recommend completely eliminating alcohol.

During pregnancy and lactation

Pregnancy and lactation are contraindications for taking the drug.

Reviews about Reduksin

Reviews of those losing weight about Reduxin 15 mg indicate that the drug is effective, primarily in combination with actively life. Patients who write on a forum dedicated to whether this remedy helps to lose weight sometimes even leave reviews with photos as evidence. Often found and positive reviews about Reduksin 10 mg. Those who have lost weight on the drug note that their appetite has decreased, respectively, their body weight has also gradually decreased.

Some women write that in the first weeks of treatment they had increased thirst. Some patients combined these capsules and diet pills from other manufacturers. However, they note that this can only be practiced under medical supervision. There are rare reviews of doctors about side effects in which we are talking that negative actions are mild and, as a rule, pass quickly. Experts note that when taking the medicine, the instructions must be followed exactly. The drug should not be taken in large doses. Sometimes even 20 mg per day can cause an increase in pressure, etc. Doctors do not recommend drinking alcohol during treatment.

Some reviews also mention the transfer of Elena Malysheva, in which the group " Lose weight with Reduksin". Malysheva claims that her participants managed to lose 15-20 kg each. Many women wrote positive reviews about it on the forum.

Reduksin's price, where to buy

The price of Reduxin 15 mg No. 60 in Moscow and St. Petersburg averages 4500 rubles. The price in Moscow pharmacies of a package of 90 capsules is an average of 5800 - 6000 rubles. Where to buy Reduxin 15 mg in Moscow with delivery, you can find out in an online store that specializes in the sale of medicines.

The price of Reduxin 10 mg in Russian pharmacies (in Omsk, Voronezh, Novosibirsk, etc.) is 1700-1800 rubles for 30 capsules. You can buy a package of 60 capsules of Reduxin 10 mg in St. Petersburg, Krasnoyarsk, Yekaterinburg for an average of 2700 rubles. The cost in pharmacies in different cities may fluctuate.