Tocopherol: instructions for use, price. Tocopherol acetate: description. Average prices for tocopherol in pharmacies. Contraindications for use

Compound:

Active substance: retinol palmitate (vitamin A)

(in terms of 100%) - 55.1 g.

Excipients: butylhydroxytoluene, butylhydroxyanisole, rapeseed oil up to 1 liter.

1 ml of solution contains 100,000 IU (1 drop of solution from a dropper or eye dropper contains 3,300 IU). 1 mg of retinol palmitate corresponds to 1817 IU.

Description: transparent oily liquid from light yellow to yellow color without rancid odor.

Pharmacotherapeutic group: Vitamin.

ATX code (A11CA01).

pharmachologic effect

Vitamin A has a general strengthening effect, normalizes tissue metabolism, participates in redox processes (due to the large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and in the processes of cholesterol formation. It enhances the production of lipase and trypsin, enhances myelopoiesis, cell division processes. It has a positive effect on the function of the lacrimal, sebaceous and sweat glands; increases resistance to diseases of the mucous membranes, respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cell population, inhibits keratinization processes, enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and epidermal cells. Stimulates cell regeneration. Participates in the processes of photoreception (contributes to human adaptation to the dark). Local action is due to the presence of specific retinol-binding receptors on the surface of epithelial cells.

Indications for use

Hypovitaminosis, beriberi A. In complex therapy:

– infectious and inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.),

- skin lesions and diseases (fissures, ichthyosiform erythroderma, acne, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis),

– eye diseases (retinitis pigmentosa, hemeralopia, xerophthalmia, keratomalacia, eczematous lesions of the eyelids),

- gastrointestinal diseases (erosive gastroduodenitis, peptic ulcer of the stomach and duodenum),

- cirrhosis of the liver.

Assign to prevent the formation of stones in the biliary and urinary tract.

Contraindications

Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases.

Carefully apply for nephritis, heart failure II-III stage, alcoholism, viral hepatitis, renal failure, old age, childhood.

Pregnancy and lactation

Dosage and administration

The use of the drug should be carried out under the supervision of a physician. The drug is taken orally after meals early in the morning or late in the evening.

Therapeutic doses for adults with mild to moderate beriberi are up to 33,000 IU / day, for children - 1000 - 5000 IU / day, depending on age.

For eye diseases, adults are prescribed 50,000-100,000 IU per day and at the same time 0.02 g of riboflavin.

In dermatology in the treatment of acne and ichthyosiform erythroderma in adults, 100,000-300,000 IU / day, children, 5,000-10,000 IU / kg per day. For skin diseases, adults are prescribed 50,000-100,000 IU of retinol palmitate per day.

In gastroenterology - 50,000 IU per day.

Single doses of retinol palmitate should not exceed 50,000 IU for adults and 5,000 IU for children. Daily doses for adults are 100,000 IU and 20,000 IU for children. For the treatment of acne and ichthyosiform erythroderma in adults, 100,000-300,000 IU.

Side effects

In some patients, with prolonged use, dry skin and mucous membranes, increased sensitivity of the skin of the face, seizures are observed. These phenomena disappear on their own when the dose is reduced or the drug is temporarily discontinued.

In the treatment of acne, after 7-10 days of administration, an exacerbation of the local inflammatory reaction is observed, which does not require additional treatment and subsequently stops. In some cases, there is intolerance to the drug, which requires its abolition.

Overdose

Long-term daily intake of vitamin A (100,000 IU - children, 200,000 IU - adults) can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, lethargy, flushing of the face, nausea, vomiting, pain in the bones of the lower extremities, gait disturbance . Children may experience: fever, drowsiness, sweating, vomiting, skin rashes. If symptoms of an overdose appear, the drug should be discontinued. Excess retinol palmitate is excreted from the body by ingestion of alcohol. With pronounced symptoms of intoxication, glucocorticosteroids should be administered orally.

Interaction with other drugs

At the beginning of the 20th century, the Polish scientist Funk first discovered specific substances, without which the human body cannot grow and develop properly. These compounds were called vitamins and are divided into 2 groups: water-soluble and fat-soluble. There are only four main fat-soluble vitamins known today: A, D, E, E, or as it is called in another way, tocopherol, is the most powerful antioxidant among all vitamins. Modern medical research points to significant promise of this vitamin in the treatment of various serious diseases and even cancer. In specialized online pharmacies, you can roughly find out the correct dosage description of the drug. Instructions for use provides more complete information about the drug.

The effect of tocopherol on the body

Vitamin E is one of the most powerful antioxidants. This determines the breadth of its application for both preventive and therapeutic purposes. The very concept of "antioxidant" stands for a substance that prevents the oxidation of other compounds with corresponding changes in their characteristics.

The human body is a fairly dynamic chemical laboratory, where various reactions take place, with oxidation being the most common. A specific subspecies is distinguished - lipid peroxidation (LPO), which consists in the attachment of peroxides to various components of the cell wall or organelles with a change in their functions. LPO develops especially intensively during inflammation, trauma, dystrophic processes and irradiation of the body. A feature of the effect of tocopherol is the binding of a certain mass of peroxide radicals, due to which the damaging effect of the latter is reduced. Thus, vitamin E acts as a protector of cells and some chemical compounds of endogenous metabolism. Fat-soluble vitamin is actively involved in tissue respiration, metabolism of fats and carbohydrates, protein synthesis and the main component of hemoglobin - heme.

Tocopherol acetate will help to effectively protect and restore both men and women. Instructions for use in surgery speak of more effective healing of wounds, burns and injuries during treatment with vitamin E. Tocopherol, together with vitamin A, increases the resistance of mucous membranes to viruses and bacteria, and is a prophylactic against Alzheimer's disease. Vitamin E is one of the factors in the restoration of peripheral circulation and the formation of red blood cells.

Release form

All fat-soluble vitamins for preservation of properties and better absorption are produced in the form of oil, available as a 5%, 10% or 30% solution for oral administration or as tablets coated with a gelatin capsule. An alternative form is intramuscular injections, which are used for debilitated patients and young children.

Indications for the use of vitamin E

The first and most relevant indication for the use of tocopherol is hypovitaminosis, which most often occurs in the spring. A powerful fat-soluble antioxidant is included in the therapy of dermatomyositis, Dupuytren's contracture, amyotrophic sclerosis. In dermatology, with various dermatoses and psoriasis, scleroderma, tocopherol is prescribed. Instructions for the use of the vitamin indicate the effectiveness of the treatment of menstrual irregularities and infertility in men. With the threat of miscarriage in pregnant women, tocopherol is almost always prescribed. Instructions for use of the antioxidant describe its action as an antispasmodic in constriction of peripheral vessels and atherosclerosis.

It performs a cardioprotective effect in various forms of cardiac muscle dystrophy. Peripheral neuropathies and degenerative processes in the liver are also considered pathologies in which tocopherol is recommended. E indicates that it minimizes the side effects of chemotherapy drugs and promotes tissue repair after a short radiation exposure.

How to use tocopherol acetate

The dose and frequency of administration is determined by the doctor. Immediately after buying the drug, you should correctly calculate the dose of the vitamin. Since solutions are 5, 10 and 30%, the amount of tocopherol in 1 milliliter should be determined in grams. For a 5% solution - this is 0.05 g, for 10% - 0.1 g and for 30% - 0.3 g. For the treatment of muscular dystrophies and amyotrophic sclerosis, the daily rate should be from 0.05 to 0.1 g. The course lasts at least 1 month with a repeat in 60-90 days. For violations of spermatogenesis and infertility in men, the dose is from 0.1 to 0.3 g per day. The approximate duration of the course is 1 month. With the threat of abortion, the drug is used for 7-14 days at a daily dose of 0.1-0.15 g per day. Vascular pathology and myocardial dystrophy are treated with acetate tocopherol at a dose of 0.1 g per day. The duration of treatment is up to 45 days with a possible repetition in six months.

As for capsules, the average dose is 2-3 per day. At the same time, 1 capsule contains 5 mg of alpha-tocopherol. Instructions for the use of vitamin E to combat hypovitaminosis recommends coordinating the dose with the doctor, due to its variability (from 10 to 30 mg / day).

Possible side effect

The instructions for the drug indicate only the possibility of developing allergic reactions after taking vitamin E. It should be remembered that allergies can manifest themselves as a slight rash or runny nose, as well as shortness of breath and even anaphylactic shock. With severe side effects, tocopherol should be immediately canceled. Instructions for use of the drug warns of the possibility of infiltrates after injections of vitamin E. This symptom occurs relatively rarely and does not require specific treatment. You just need to frequently change injection sites and carry out a light massage of the infiltrate by the time it disappears.

Is it possible to overdose on vitamin E?

Cases of overdose are rare, but its symptoms are quite non-specific. Patients report nausea, visual disturbances, headache. Often against this background, thrombophlebitis and even hemorrhagic stroke can develop. If you have noted the indicated symptoms, you should urgently consult a doctor and cancel tocopherol. Instructions for use of the drug indicates the symptomatic treatment of overdose in a hospital setting.

Contraindications

Hypersensitivity is a contraindication to taking the drug, so it is advisable to immediately forget about what tocopherol acetate is. Instructions for use describe such body reactions as photodermatitis, lacrimation, rhinorrhea, or any variant of an allergic reaction.

Interactions of vitamin E with other drugs

A fat-soluble antioxidant should not be used in combination with drugs that have an alkaline pH, as well as compounds based on iron and silver. These funds significantly weaken the absorption of the vitamin, as a result of which the treatment is not entirely effective.

Average prices for tocopherol in pharmacies

The approximate price for 5 mg is 35-45 rubles. for 10 capsules.

Alpha-tocopherol 30% solution (in a 50 ml bottle) can be purchased for 67-120 rubles.

Vitamin E for athletes

Tocopherol is increasingly used as part of a special diet for athletes and bodybuilders. Its use is associated with the ability of the vitamin to improve peripheral circulation, which is very important for muscle growth, as well as recovery from minor injuries. Inhibition of peroxidation enhances metabolic processes and better absorption of proteins, which every experienced professional athlete takes. In addition, alpha-tocopherol improves the metabolism of the heart muscle, which is one of the conditions for significant physical endurance.

In most cases, the diet of a professional athlete cannot provide a sufficient supply of this vitamin to the body. Therefore, you should replenish its supply with tablet forms of the antioxidant. The dosage is quite individual and specific for different types of sports, which is taken into account by a sports doctor when prescribing tocopherol. Instructions for use, price and natural sources of vitamin E, which are given in the article, will help athletes choose for themselves the best way to replenish the body with this antioxidant.

natural sources

To replace tablets or injections of tocopherol, you can use products that contain the most of it. This applies in particular to cereal germs, nuts and unrefined oils. Sufficient amounts of vitamin E can be found in egg yolks, liver, butter, and cheese. By including these foods in your diet, you prevent vitamin E deficiency and improve the condition of the nervous system, skin and hair.

Producer: JSC "Marbiopharm" Russia

ATS code: A11HA03

Farm group:

Release form: Liquid dosage forms. Oil solution.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

There is a saying “vitamins are life”. Modern medicine does not deny this, because the lack of any substance can cause serious disruptions in the body. In this article, we will analyze what alpha-tocopherol acetate is, how its intake affects human health and the features of its use.

Alpha-Tocopherol acetate in its composition has:

• active substance - vitamin E;
• auxiliary component - refined sunflower oil.

Literally, "tocopherol" can be translated as "bearing offspring." In 1920, its reproductive role was first discovered. The experiment was carried out on rats: they were fed only skim milk, which contained a small amount of tocopherol compounds. Soon the rats stopped breeding. Also, scientists have noticed the death of the fetus in pregnant rats and a decrease in the amount of seminal epithelium in males.

Vitamin E has one feature: the body is not able to produce it on its own.. It can only be obtained with food and taking vitamin complexes. It was first synthesized from cereal oils in 1938.

In addition to the effect on the reproductive function of tocopherol acetate has other important functions for the human body. No wonder it is considered the main representative in the group of antioxidants.

Release form

Alpha Tocopherol Acetate is available as softgels, chewable lozenges, and oily solutions. There are also solutions for intramuscular injection. They are produced on the basis of peach and olive oils. Among the most common forms of release are:

• dragee 100 mg;
• oil solution in the form of capsules of 100, 200 and 400 mg;
• 50% solution for external use, produced in a glass jar;
• 5% and 10% solution for intramuscular injections.

Instructions for use are mandatory attached to all drugs.

The cost of the drug depends on its form of release. The price of capsules is about 20-30 rubles. The cost of a 30% solution is approximately 70 rubles.

Indications for use

Alpha-Tocopherol acetate is prescribed in the following cases:

1. Irritability and neurasthenia.
2. Violations of the function of the gonads in men.
3. Menstrual disorders.
4. Increased physical activity.
5. Fibrotic diseases of the breast in women.
6. Arthritis.
7. Psoriasis.
8. Seizures.
9. In case of living in special climatic conditions (highlands).
10. During puberty and during intensive growth.
11. Skin diseases (ulcer, eczema, dermatitis).
12. Vegetative disorders.
13. Eye diseases.
14. While taking hormonal drugs.
15. Hypervitaminosis of vitamins D and A.
16. During pregnancy, to reduce the risk of miscarriage and prevent abnormal fetal development.
17. lactation period.

The effect of the drug on the body

As noted above, vitamin E is one of the most powerful antioxidants. It is able to increase the resistance of cells to those substances that paralyze their work. Together with its "partner" vitamin C, tocopherol prevents the development of the peroxidation reaction and reduces the risk of cancer cells.

The effect of the drug is not limited to this. Vitamin E is needed by the circulatory system and all tissues of the human body. Alpha-Tocopherol acetate improves blood circulation and its clotting, saturates tissues with oxygen, restores the central nervous system, prevents blood clots and slows down fat oxidation.

This medication is used to normalize the reproductive system of men and women. It eliminates menstrual irregularities, restores sperm production and enhances sexual desire. In addition, Alpha-Tocopherol acetate has a beneficial effect on the growth of the fetus in the mother's womb, and also contributes to a surge of vitality in a pregnant woman.

The drug is also popular in cosmetology. It helps to cope with problems such as brittle hair and nails, dry skin.

Method of application and dosage

Many are interested in how to take the drug, because it is available in various forms. The method of application, dosage and course of taking Alpha-Tocopherol acetate depends on the disease and is determined strictly by the doctor.

The drug should be taken with food, drinking plenty of water. The usual daily dosage is 100-300 mg. As prescribed by the doctor, it can be increased to 1 g.

The instructions for use say that the duration of the course and the exact doses depend on the purpose of the reception:

1. For the prevention of hypovitaminosis, 100 mg twice a day is prescribed. The course is 1-3 weeks.
2. In the case of spermatogenesis, take 100-300 mg. The course is a month.
3. In case of violation of the menstrual cycle, 300-400 mg are prescribed. It is necessary to start taking from the 17th day of the cycle and so on for 5 cycles.
4. During pregnancy - 100 mg daily in the first trimester.
5. In diseases of the neuromuscular system, 100 mg is prescribed every day. The course lasts 1-2 months.
6. With neurasthenia, 100 mg should be taken every day. The course is 1-2 months.
7. For diseases of the skin, 100 mg daily is prescribed. The course is 20-40 days.

Side effects and contraindications

After taking Alpha-Tocopherol Acetate, some side effects may occur. These include:

• pain in the abdomen, which is accompanied by diarrhea and nausea;
• allergic reactions (itching, rash, urticaria, angioedema);
• soreness and infiltration at the injection site.

Among the contraindications, individual intolerance is distinguished. Caution should be taken in the presence of the following diseases:

• severe cardiosclerosis;
• myocardial infarction;
• vitamin K deficiency;
• thromboembolism.

Medication analogues

Among the analogues of Alpha-Tocopherol acetate, the following can be distinguished:

1. Alpha-Tocopherol-UVB.
2. Biovital vitamin E.
3. Vitamin E-Slovakofarm.
4. Vitamin E Zentiva.
5. Vitrum vitamin E.
6. Doppelgerz Vitamin E forte.
7. Evion.

Vitamin E is a strong antioxidant that plays an important role in human health. It can only be obtained from the outside, that is, from products or multivitamins. An excellent way to replenish your vitamin E supply is to take Alpha-Tocopherol Acetate. Before use, be sure to read the instructions and consult with your doctor.

Compound

Alpha-tocopherol acetate - 300 g sunflower oil (refined deodorized sunflower oil) - up to 1 liter.

Dosage form

Oil solution for oral administration.

Description

Transparent oily liquid from light yellow to dark yellow without rancid odor.

A greenish tint is allowed.

Action

A fat-soluble vitamin whose function remains unclear. As an antioxidant, it inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. Together with selenium, it inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transport system), and prevents erythrocyte hemolysis. It is a cofactor of some enzyme systems.

Pharmacodynamics

Pharmacokinetics

Absorption from the duodenum (requires the presence of bile salts, fats, normal pancreatic function) -50-80%. It binds to blood beta-lipoproteins. If protein metabolism is disturbed, transport is hindered. The time required to reach the maximum concentration (TCmax) is 4 hours. It is deposited in all organs and tissues, especially in adipose tissue. Penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the mother's blood penetrates into the blood of the fetus. Penetrates into breast milk. Metabolized in the liver to derivatives with a quinone structure (some of them have vitamin activity). It is excreted in the bile - more than 90% (a certain amount is reabsorbed and subjected to enterohepatic circulation), by the kidneys - 6% (in the form of tocoferonic acid glucuronides and its gamma-lactone). It is excreted slowly, especially in premature and newborns, in whom its accumulation is possible.

Indications for use

Hypovitaminosis E and increased need of the body for vitamin E (including in newborns, premature or low birth weight, in young children with insufficient intake of vitamin E from food, with peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia, gastrectomy, chronic cholestasis , cirrhosis of the liver, atresia of the biliary tract, obstructive jaundice, celiac disease, tropical sprue, Crohn's disease, malabsorption, with parenteral nutrition, pregnancy (especially with multiple pregnancies), nicotine addiction, drug addiction, during lactation, when taking cholestyramine, colestipol, mineral oils and iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids).

Contraindications

Hypersensitivity.

Use in children

Newborns with low body weight: to prevent the development of hemolytic anemia,

  bronchopulmonary dysplasia, complications of retrolental fibroplasia.

Side effects

Allergic reactions.

Interaction

When used together, it facilitates absorption, deposition in the liver, assimilation and reduces the toxicity of vitamin A. The appointment of vitamin E in high doses can cause vitamin A deficiency in the body. Reduces the toxicity of vitamin D. The simultaneous use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding. Colestyramine, colestipol, mineral oils reduce the absorption of vitamin E. High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Dosage and administration

Prevention of hypovitaminosis E. Adults and children over 10 years old: men - 10 mg / day (10 drops of a 50 mg / ml solution, 5 drops of a 100 mg / ml solution or 2 drops of a 300 mg / ml solution), women - 8 mg / day ( 8 drops of a 50 mg / ml solution, 4 drops of a 100 mg / ml solution or 1 drop of a 300 mg / ml solution), pregnant women - 10 mg / day (10 drops of a 50 mg / ml solution, 5 drops of a 100 mg / ml solution or 2 drops solution 300 mg / ml), nursing mothers - 11-12 mg / day (11-12 drops of a solution of 50 mg / ml, 5-6 drops of a solution of 100 mg / ml or 2 drops of a solution of 300 mg / ml) for children under 3 years old - 3-6 mg / day (3-6 drops of a 50 mg / ml solution, 2-3 drops of a 100 mg / ml solution or 1 drop of a 300 mg / ml solution), 3-10 years - 7 mg / day (7 drops of a solution of 50 mg/ml, 3 drops of a 100 mg/ml solution or 1 drop of a 300 mg/ml solution respectively

Doses and duration of treatment for hypovitaminosis E are individual and depend on the severity of the condition.

 With caution Hypoprothrombinemia (against the background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 IU).

Overdose

Symptoms: when taken for a long period at doses of 400 - 800 IU / day (1 mg = 1.21 IU) - blurred visual perception, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia when taking more than 800 IU / day for a long period - an increase in the risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, sexual dysfunction, thrombophlebitis, thromboembolism.

Treatment is symptomatic, drug withdrawal, administration of glucocorticosteroids.

special instructions

According to the approved norms of physiological requirements for energy and nutrients for various groups of the population of the Russian Federation from 2008, the need for vitamin E for children: up to 6 months - 3 mg, from 6 months to 3 years - 4 mg, from 3 to 7 years - 7 mg, from 7 to 11 years old - 10 mg, from 11 to 14 years old - 12 mg, from 14 to 18 years old - 15 mg. Adults - 15 mg / kg, pregnant women - 17 mg / day, nursing mothers - 19 mg / day. The maximum daily intake is 300 mg / day.

 Tocopherols are found in the green parts of plants, especially in young cereal sprouts, large amounts of tocopherols are found in vegetable oils (sunflower, cottonseed, corn, peanut, soybean, sea buckthorn). Some of them are found in meat, fat, eggs, milk. It should be borne in mind that in newborns with low body weight, hypovitaminosis E may occur due to the low permeability of the placenta (the blood of the fetus contains only 20-30% of vitamin E from its concentration in the mother's blood). A diet with a high content of selenium and sulfur-containing amino acids reduces the need for vitamin E. With the routine administration of vitamin E to newborns, the benefit should be weighed against the potential risk of necrotizing enterocolitis. Currently, the effectiveness of vitamin E is considered unreasonable in the treatment and prevention of the following diseases: beta-thalassemia, cancer, fibrocystic breast dysplasia, inflammatory skin diseases, hair loss, recurrent miscarriage, heart disease, "intermittent" claudication, postmenopausal syndrome , infertility, peptic ulcer, sickle cell anemia, burns, porphyria, neuromuscular conduction disorders, thrombophlebitis, impotence, bee stings, senile lentigo, bursitis, diaper dermatitis, pulmonary intoxication due to air pollution, atherosclerosis, aging. The use of vitamin E to increase sexual activity is considered unproven.

Release form

Oral solution oily 300 mg / ml.  50 ml in vials.

A dropper bottle or a bottle, together with instructions for use, is placed in a pack of cardboard for consumer packaging.

Terms of dispensing from pharmacies

Released without a prescription.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C

Best before date

Shelf life: 2 years. Do not use after the expiration date

Manufacturer and organization accepting consumer claims

Manufacturer and enterprise for accepting claims Marbiopharm OJSC, 424006,