Antigrippin effervescent tablets for adults. Antigrippin powder. International non-proprietary name or grouping name

Antigrippin is a drug for the symptomatic treatment of acute respiratory diseases.

Release form and composition

The active ingredients of Antigrippin are paracetamol, ascorbic acid and chlorphenamine. The combination of auxiliary components depends on the form of release of the drug. As a rule, these are citric acid, sucrose, sodium bicarbonate, aspartame, povidone, sorbitol, sodium saccharinate, macrogol, sodium carbonate, various flavors and taste correctors, etc.

Antigrippin is sold in the following dosage forms:

• Powder for solution for oral administration honey-lemon or chamomile. Consists of particles from pure white to light brown or beige. Inclusions of brown or dark brown color are allowed. Has a specific smell;
• Effervescent tablets with raspberry or grapefruit flavor. They have a round flat shape, as well as a beveled edge and a dividing risk on one side. The color of the tablets depends on the flavor used: with raspberry flavor - pink or pinkish-lilac, with grapefruit flavor - white or creamy white. They have a specific fruity or citrus smell;
• The tablets are effervescent. They have a flat round shape and a beveled edge. On one side of the tablet there is a separating line. Color - white or almost white, slightly marbled. Smell - light fruity;
• Effervescent tablets for children. They have a flat round shape, standard for all Antigrippin tablets, a beveled edge and a dividing risk. The color is pink, with randomly arranged darker or lighter blotches. They have a fruity scent.

Indications for use Antigrippin

According to the instructions, Antigrippin is prescribed for infectious and inflammatory diseases (flu and SARS), which are accompanied by chills, headache, fever, nasal congestion, pain in the muscles and joints, as well as in the sinuses and throat.

Contraindications

General contraindications to the use of Antigrippin (for all dosage forms) are:

• Hypersensitivity to ascorbic acid, paracetamol, chlorphenamine or any other components of the drug;
• Angle-closure glaucoma;
• Exacerbations of erosive and ulcerative lesions of the gastrointestinal tract;
• Severe liver or kidney failure.

Additional contraindications for all forms of release, except for effervescent tablets for children, are:

• Phenylketonuria;
• Alcoholism;
• Hyperplasia of the prostate;
• Pregnancy and the period of breastfeeding;
• Children's age up to 15 years.

Effervescent tablets for children should not be given to babies under three years of age.

According to the instructions, Antigrippin is prescribed with caution for congenital hyperbilirubinemia, viral hepatitis and deficiency of the enzyme glucose-6-phosphate dehydrogenase.

All drugs, except for effervescent tablets for children, require careful use in the elderly, with alcoholic hepatitis, hyperoxalaturia and progressive malignant diseases.

Method of application and dosage of Antigrippin

All dosage forms are taken orally.

The recommended dosage for adults and children over 15 years of age, indicated in the instructions for Antigrippin (powders and effervescent tablets): one tablet or one sachet of the drug 2-3 times a day. The maximum daily dose of Antigrippin is 3 tablets or 3 sachets.

For children under 15 years of age, the drug is prescribed in the following dosages:

• 3-5 years - half a tablet twice a day;
• 5-10 years - one tablet twice a day;
• 10-15 years - one effervescent tablet 2-3 times a day.

The duration of taking Antigrippin without consulting a specialist is not more than 3 days in case of use as an antipyretic and not more than 5 days - as an anesthetic.

Side effects of Antigrippin

The drug is well tolerated if the recommended doses are not exceeded.

In isolated cases, when using Antigrippin, side effects such as:

• Feeling tired, headache;
• Drowsiness;
• hypoglycemia;
• Pain in the epigastric region;
• Nausea;
• dry mouth;
• Anemia;
• Thrombocytopenia (extremely rare);
• Urticaria, itching;
• Skin rash;
• Quincke's edema;
• feeling of heat;
• Urinary retention;
• hypervitaminosis;
• Paresis of accommodation;
• Metabolic disease.

Any adverse reactions that occur should be reported to the doctor immediately.

special instructions

With prolonged use of Antigrippin in doses that significantly exceed those recommended, the risk of developing impaired renal and hepatic function increases, and it is necessary to control the peripheral blood picture.

Ascorbic acid and paracetamol, which are part of Antigrippin, can distort the real indicators of laboratory tests.

When prescribing ascorbic acid to patients with intensively metastasizing and rapidly proliferating tumors, the course of the process may be aggravated. Patients with high iron content are recommended minimum doses of ascorbic acid.

When using Antigrippin, you should refrain from taking alcoholic beverages, since when used together, the risk of toxic liver damage increases.

Antigrippin's analogs

There are a lot of drugs similar to Antigrippin in terms of their action and active ingredients. These drugs include: Anticatarrhal, Aurora hotsip, Astracitron, Glycodin, Vicks active symptomatic, Gripex, Gripomed, Gripflu, Coldrex, Coldrin, Lekadol, Maxicold, Milistan, Padeviks, Rinza hotsip, Stopgripan, Theraflu, Pharmacitron, Fervex, Efferalgan, etc. .

Terms and conditions of storage

Antigrippin should be stored at a temperature of 10 to 30 ° C in a dry place out of the reach of children. The shelf life of the drug is three years.

Colds are accompanied by various negative symptoms. Children are especially sensitive to discomfort and fever. In order to speed up the healing process, many experts prescribe Antigrippin to babies. However, some parents doubt its effectiveness and safety. Below is a detailed instruction for use and description of the drug.

Composition, form of release and mechanism of action of Antigrippin

Antigrippin is classified as a complex drug. It has anti-inflammatory, antipyretic, analgesic and immunostimulatory effects. The main components of the drug: ascorbic acid, paracetamol and chlorphenamine. Thanks to this combination, Antigrippin fights several symptoms of colds at once:

• paracetamol lowers body temperature, reduces pain and stops the inflammatory process;
• ascorbic acid improves the body's resistance to infections;
• chlorphenamine has an antihistamine effect: relieves swelling of the nasopharynx, tearing, redness of the eyes, eliminates sneezing and itching.

Excipients of the drug are aimed at maintaining the shape and giving taste. Additional substances include: citric acid, soda, sorbitol, povidone, sodium saccharinate, silicon dioxide, various flavors, macrogol. Antigrippin is produced in the form of tablets and powder. For children, there is a special form of the drug - effervescent tablets.

Indications for use for children

Dear reader!

This article talks about typical ways to solve your questions, but each case is unique! If you want to know how to solve your particular problem - ask your question. It's fast and free!

The medicine is intended to combat the manifestations of influenza and SARS. Due to the complex action, Antigrippin is able to replace several drugs. Thus, children do not need to be given several different types of pills, but taking one medication is enough.

When the first signs of SARS appear, the use of Antigrippin is very popular.

The main indications for the use of the drug:

• high body temperature;
• chills;
• discomfort in the joints and muscles;
• swelling of the nasopharyngeal mucosa;
• headache;
• itchy nose and sneezing;
• sore throat;
• convulsions due to intense heat;
• bacterial diseases of the upper respiratory system;
• prevention of seasonal colds.

Contraindications

Like any drug, Antigrippin for children has a number of contraindications. Instructions for use states that the drug should not be taken by babies under 3 years old. This is due to the fact that complex drugs have a more powerful effect on the body than its individual components.

Any treatment of a child must be agreed with the pediatrician: since Antigrippin has its own contraindications, the doctor may prohibit the use of this drug

Contraindications also include the following conditions:

• hypersensitivity to one of the components of the drug;
• ulcerative lesions of the stomach and intestines;
• diseases of the liver and kidneys;
• angle-closure glaucoma;
• viral hepatitis;
• anemia;
• violation of hematopoietic processes;
• phenylketonuria.

Side effects

The drug is usually well tolerated by patients. To minimize the risk of complications, it is necessary to strictly adhere to the age dosages of the drug. It is unacceptable to give babies the adult form of the drug.

Among the possible side effects of Antigrippin are:

• feeling tired;
• fast fatiguability;
• insomnia, irritability;
• increased sweating;
• headache;
• pain and spasms in the epigastric region;
• nausea and vomiting;
• the appearance of allergies (itching, various rashes, Quincke's edema);
• anemia;
• decrease in blood glucose;
• violation of visual function;
• urination problems;
• dryness of the oral mucosa;
• metabolic deterioration.

Instructions for use and dosage

The children's form of the drug is represented by effervescent tablets. According to the instructions for children's Antigrippin, before taking it, it is dissolved in 200 ml of warm water without gas. Drink the medicine between meals with an interval of more than 4 hours. To eliminate the heat, it is recommended to take it up to 3 days, as an analgesic - no longer than 5 days.

It is necessary to use the drug strictly according to the instructions.

The dosage of Antigrippin for children by age is described in the table:

Antigrippin powder is allowed for children from 15 years of age. The powder must be diluted in warm water and drunk immediately. Single dose - 1 sachet. No more than 3 sachets are allowed per day. The duration of taking Antigrippin powder is similar to the medicine in the form of tablets.

Interaction with other drugs

Various drugs are advised to drink at intervals of 30 minutes. However, taking some drugs together with Antigrippin is not recommended, as this can lead to adverse reactions.

It is impossible to use medicines that contain paracetamol at the same time as this medication, as this will cause an overdose of the active substance.

The use of antidepressants and phenothiazine derivatives leads to constipation, dry mouth and problems of the genitourinary system. Medications with glucocorticosteroids affect the development of vision problems. The combined use of drugs with Antigrippin that correct the work of the central nervous system (barbiturates, phenytoin, antidepressants) leads to severe intoxication of the body.

Barbiturates also reduce the effect of paracetamol and ascorbic acid. Antigrippin reduces the effectiveness of antipsychotics and drugs that promote the excretion of uric acid by the kidneys. When prescribing a medicine for a cold to a child, it is necessary to inform the doctor about the medicines that the patient is currently taking.

Price and similar means

Antigrippin for children is an over-the-counter drug. It can be found in many pharmacy chains. The price of a package of a medicinal product depends on the number of tablets. The cost of 10 effervescent tablets is 200 - 300 rubles, 30 tablets - about 500 rubles. There are no absolute analogues of the drug, but there are drugs that have a similar therapeutic effect.

Coldrex Junior - a drug with a similar therapeutic effect

Analogues are presented in the table:

Name of the drug	Active substances	Release form	Age restrictions
Fervex for children	paracetamol, ascorbic acid, pheniramine	powder for oral administration	from 6 years old
Maxicold	ibuprofen	suspension	from 3 months
Coldrex Junior	phenylephrine	hot drink powder	from 6 years old
Antiflu Kids	ascorbic acid, paracetamol, chlorphenamine maleate	instant powder	from 2 years old
Agri children's	homeopathic ingredients	tablets, granules	from 1 year
Efferalgan with Vitamin C	paracetamol, ascorbic acid	effervescent tablets	from 8 years old
Gripgo	paracetamol, caffeine, phenylephrine hydrochloride, chlorpheniramine maleate	tablets	after 12 years

Antigrippin has proven itself well as a children's remedy for colds. Some parents use it for a child's toothache (see also:). It has a pleasant taste and kids love it. However, like any drug, the drug should not be used without consulting a specialist.

REGISTRATION NUMBER: LSR-005321/08 dated 25.05.2009

TRADE NAME: Antigrippin

INTERNATIONAL NON-PROPRIETARY NAME OR GROUP NAME:
Paracetamol + Chlorphenamine + Ascorbic Acid

PHARMACEUTICAL FORM:
effervescent tablets with raspberry flavor, grapefruit flavor

Active substances:
paracetamol - 500 mg
chlorphenamine maleate - 10 mg
ascorbic acid - 200 mg

Excipients:

sodium bicarbonate, citric acid, sorbitol, povidone, sodium saccharinate, aspartame, sodium carbonate, macrogol, sodium lauryl sulfate, sodium riboflavin-5-phosphate, raspberry flavor (raspberry aromatic fruit additive), taste corrector, red beet juice powder.

sodium bicarbonate, citric acid, sorbitol, povidone, aspartame, sodium carbonate, macrogol, sodium lauryl sulfate, sodium riboflavin-5-phosphate, lemon flavor (aromatic fruit additive "Lemon"), grapefruit flavor (aromatic fruit additive "Grapefruit"), corrector taste.

DESCRIPTION:

Effervescent tablets with raspberry flavor: tablets are round, flat, with a bevelled edge and a dividing risk on one side, pink, pinkish-lilac or lilac in color, with lighter and darker patches, with a specific fruity odor.

Grapefruit flavored effervescent tablets: tablets are round, flat, with a bevelled edge and a separating risk on one side, white, almost white or creamy white in color, with a barely noticeable marbling, with a specific citrus odor.

PHARMACOTHERAPEUTIC GROUP:

Means for eliminating the symptoms of acute respiratory infections and "colds" (an analgesic non-narcotic drug + vitamin + H1-histamine receptor blocker)

ATX code

PHARMACOLOGICAL PROPERTIES:

Combined drug. Paracetamol has analgesic and antipyretic action; eliminates headache and other types of pain, reduces fever. Ascorbic acid (vitamin C) participates in the regulation of redox processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine- blocker H 1 -histamine receptors, has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

class="itoc_n" id="pok1">INDICATIONS FOR USE:

Infectious and inflammatory diseases (SARS, influenza), accompanied by fever, chills, headache, pain in the joints and muscles, nasal congestion and pain in the throat and sinuses.

class="itoc_n" id="protiv1">CONTRAINDICATIONS:

Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug. Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase). Severe renal and / or liver failure. Alcoholism. Angle-closure glaucoma. Phenylketonuria. Hyperplasia of the prostate. Children's age (up to 15 years). Pregnancy (I and III trimester) and lactation.

With caution - renal and / or liver failure, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), hyperoxalaturia, progressive malignant diseases, viral hepatitis, alcoholic hepatitis, old age.

class="itoc_n" id="doza1">DOSE AND ADMINISTRATION:

inside. Adults and children over 15 years old: 1 tablet 2-3 times a day. The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution should be drunk immediately. It is better to take the drug between meals. The maximum daily dose is 3 tablets. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

The duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

SIDE EFFECTS:

The drug is well tolerated at recommended doses.
In isolated cases, there are:
from the CNS: headache, feeling tired;
from the gastrointestinal tract: nausea, pain in the epigastric region;
from the endocrine system: hypoglycemia (up to the development of coma);
from the hematopoietic organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rarely - thrombocytopenia;

allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactoid reactions (including anaphylactic shock), erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome);
others: hypervitaminosis, metabolic disorders, sensation of heat, dry mouth, paresis of accommodation, urinary retention, drowsiness.

All side effects of the drug should be reported to the doctor.

OVERDOSE:

Symptoms of an overdose of the drug are due to its constituent substances. The clinical picture of an acute overdose of paracetamol develops within 6-14 hours after taking it. Symptoms of chronic overdose appear 2-4 days after increasing the dose of the drug. Symptoms of acute paracetamol overdose: diarrhea, loss of appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Symptoms of an overdose of chlorphenamine: dizziness, agitation, sleep disturbances, depression, convulsions.
Treatment: symptomatic.

class="itoc_n" id="vzaimo1">INTERACTIONS WITH OTHER DRUGS:

Increases the concentration of benzylpenicillin and tetracyclines in the blood.

Improves absorption in the intestines of iron preparations (converts ferric iron to ferrous); May increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol.

Ethanol enhances the sedative effect of antihistamines.

Antidepressants, antiparkinsonian drugs, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids - increase the risk of developing glaucoma.

With simultaneous use reduces the chronotropic effect of isoprenaline.

It can either increase or decrease the effect of anticoagulant drugs.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses. Ethanol contributes to the development of acute pancreatitis.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxicity. Simultaneous administration of the drug and diflunisal increases the concentration of paracetamol in the blood plasma by 50%, and increases hepatotoxicity. Simultaneous reception of barbiturates reduces the effectiveness of paracetamol, increases the excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.
Enhances the effect of sleeping pills.

SPECIAL INSTRUCTIONS:

If you are taking metoclopramide, domperidone or cholestyramine, you should also consult your doctor.

With prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases, and monitoring of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid can distort laboratory tests (quantification of glucose and uric acid in blood plasma, bilirubin, activity of "liver" transaminases, LDH).

To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages, and should not be taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis.

The appointment of ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the course of the process. In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

RELEASE FORM:

Effervescent tablets with raspberry flavor, grapefruit flavor.
10 tablets in a plastic case or in a PVC/Al blister; 2, 4 or 6 tablets per Al/Al strip.
1, 2, 3, 4, 5 blisters or 5, 10, 15, 20 strips in a cardboard box along with instructions for use.

1 pencil case in a cardboard pack or in an envelope pack with a hanging device along with instructions for use.

STORAGE CONDITIONS:
At a temperature of 10-30°C, in a dry, dark place.
Keep out of the reach of children!

EXPIRY DATE: 3 years.
Do not use after the expiration date.

TERMS OF DELIVERY FROM PHARMACIES:
Without recipe.

MANUFACTURER:
Natur Produkt Pharma Sp.z o.o., Natur Produkt Pharma Sp. s o. o., st. Podstoczysko, 30, 07-300 Ostrow Mazowiecka, Poland.

By order and under control:
Natur Produkt Europe B.V.,
Natur Product Europe B.V., Tveiberg 17, 5246 XL, Rosemalen, The Netherlands.

REPRESENTATIVE OFFICE IN RUSSIA / ADDRESS OF THE ORGANIZATION RECEIVING CLAIMS:
CJSC "Natur Product International"
St. Petersburg, 197022, st. Etc. Popova, 37, letter A

According to the accepted medical classification, Antigrippin is a drug intended for the symptomatic treatment of acute respiratory diseases and the common cold. The Antigrippin medication is produced by Polish and Dutch pharmaceutical factories, and includes ascorbic acid, chlorphenamine and paracetamol as active substances. Check out its instructions for use.

Composition of Antigrippin

The analgesic drug is available in two forms: effervescent tablets and powder for oral solution. Their composition:

Pharmacodynamics and pharmacokinetics

The properties of the combined preparation depend on the ingredients included in it. The instruction points to the properties of the components:

1. Paracetamol - exhibits antipyretic, analgesic properties, relieves pain, fever.
2. Vitamin C - ascorbic acid regulates the processes of oxidation-reduction, carbohydrate metabolism, increases the body's resistance.
3. Chlorphenamine is a blocker of histamine receptors, an anti-allergic component facilitates nasal breathing, reduces the feeling of nasal congestion, eliminates itching, sneezing, tearing, and redness of the eyes.

Antigrippin - antibiotic or not

Patients taking Antigrippin often worry about whether it is an antibiotic. According to the instructions, the drug does not contain antibacterial components, therefore, it cannot belong to this group of drugs. The drug does not kill the infection and the viruses that caused the disease, but only corrects the symptoms of its manifestation. The drug is relatively safe to use.

Indications for use

According to the instructions, Antigrippin can be used to treat influenza, acute respiratory and viral infectious diseases in adults and children. The drug well eliminates the symptoms that accompany these diseases:

• elevated temperature;
• chills;
• headache;
• pain in the joints and muscles;
• nasal congestion;
• pain in the throat, sinuses.

Method of application and dosage

Instructions for the use of Antigrippin are different for each of the release formats, but all types of medication are taken orally, inside. The duration of use should not be more than three days when using the drug as an antipyretic, and more than five days as an anesthetic. With pathologies of the kidneys, liver, in old age, the interval between doses increases (up to 8 hours).

Antigrippin powder

Patients over 15 years of age are recommended to take antigrippin in powder, one sachet 2-3 times a day. The contents of the sachet are dissolved in a glass of warm water, the solution is drunk immediately. It is optimal to take the remedy between meals. No more than three sachets are allowed per day with intervals between doses of 4 hours. For older people, you can take the solution every 8 hours.

Tablets Antigrippin

Antigrippin effervescent tablets are allowed to be taken by patients over 15 years of age. For a day it is supposed to take 2-3 times one tablet dissolved in a glass of warm water (50-60 degrees). A maximum of three tablets can be taken per day. A minimum of 4 hours should elapse between doses of the dissolved agent. With pathologies of the liver and kidneys, it is necessary to increase the interval between doses to eight hours.

Children's Antigrippin

Effervescent tablets Antigrippin in children's dosage can be taken by patients older than three years. Up to five years, the dose will be half a tablet twice a day. Children 5-10 years old need to drink one tablet twice a day, adolescents 10-15 years old - one tablet 2-3 times a day. The dose is dissolved in a glass of warm water, the solution is drunk immediately, the interval between doses should be at least 4 hours.

special instructions

In the instructions for the use of Antigrippin there is a section of special instructions. It contains the following information:

1. When combined therapy with Metoclopramide, Colestyramine, Domperidone, you need to get a doctor's consultation.
2. With prolonged use of doses of the drug that exceed those recommended by the instructions, there is a possibility of disruption of the liver and kidneys. It is required to control the state of the blood.
3. Paracetamol and vitamin C can distort laboratory tests to determine the level of glucose, uric acid, bilirubin, liver enzyme activity.
4. If the drug is prescribed to patients with rapidly developing, metastasizing and proliferating tumors, then ascorbic acid can aggravate the process.
5. With an increased iron content in the body, it is recommended to reduce the intake of vitamin C to a minimum.

During pregnancy

The use of tablets and powder Antigrippin during pregnancy is contraindicated, because the active ingredients penetrate the placental barrier and can cause damage to the fetus. When breastfeeding (lactation), drugs based on paracetamol and chlorphenamine should also not be taken, because they are found in breast milk.

drug interaction

Drug interactions of Antigrippin with other medicines should be studied in order to be aware of possible dangers. Instructions for use contains this section:

1. The combination of the drug with antidepressants, antipsychotics, antiparkinsonian drugs, phenothiazine derivatives leads to an increased risk of side effects.
2. The combination of the drug with glucocorticoids increases the likelihood of developing glaucoma.
3. Simultaneous reception of Antigrippin with Isoprenaline reduces the chronotropic effect of the latter.
4. The drug reduces the effect of neuroleptics, tricyclic antidepressants, tubular reabsorption of amphetamine, alkaloids, anticoagulants, salicylates, sulfonamides, antibiotics of the Tetracycline group.
5. The combination of the drug with Phenytoin tablets, Rifampicin, barbiturates, Phenylbutazone leads to the development of severe intoxication, an increase in the excretion of Antigrippin.
6. Cimetidine reduces the risk of drug hepatotoxicity.
7. Diflunisal increases the concentration of paracetamol in the blood plasma and leads to manifestations of hepatotoxicity. Barbiturates reduce the effectiveness of paracetamol and increase the rate of excretion of ascorbic acid.
8. Paracetamol reduces the effect of uricosuric drugs, benzylpenicillins.

Antigrippin and alcohol

The simultaneous use of Antigrippin with alcohol is strictly prohibited in order to avoid liver damage and intoxication. During therapy, you can not drink ethanol-based drinks, prescribe medication to patients prone to alcoholism. If a patient has alcoholic hepatosis, the risk of acute pancreatitis increases. Ethanol enhances the effect of the antihistamine substance of the composition.

Side effects and overdose

According to studies, the drug is well tolerated in the recommended doses. Rare side effects are:

• fatigue, headache, overexcitation;
• nausea, epigastric pain;
• hypoglycemia, development of coma;
• anemia, hemolytic anemia (with deficiency of glucose-6-phosphate dehydrogenase), thrombocytopenia;
• anaphylactic shock, angioedema, itching, skin rash, urticaria;
• hypervitaminosis;
• hyperhidrosis;
• metabolic disorders;
• constipation;
• dry mouth;
• accommodation paresis;
• urinary retention, hyperoxalaturia, crystalluria;
• drowsiness.

Overdose may occur due to an excess dose of paracetamol or chlorphenamine. Signs of paracetamol poisoning include diarrhea, increased sweating, decreased appetite, abdominal pain, nausea, stomach discomfort, and vomiting. Symptoms of an overdose of chlorphenamine are manifested by convulsions, dizziness, depression, agitation, drowsiness. Symptomatic treatment is carried out.

Contraindications

The drug is prescribed with caution in case of renal, hepatic insufficiency, congenital hyperbilirubinemia, viral hepatitis. The instruction highlights contraindications to the use of Antigrippin:

• hypersensitivity to the components of the composition;
• prostatic hyperplasia;
• malignant neoplasms;
• phenylketonuria;
• exacerbation of erosions, ulcers of the gastrointestinal tract;
• angle-closure glaucoma;
• children's age up to three years for effervescent tablets.

Terms of sale and storage

All forms of release of Antigrippin are dispensed without a prescription, stored at a temperature of 10-30 degrees in a dark place, out of reach of children, for three years.

Analogues

Drugs with the same active composition or similar therapeutic effect can replace the medication. These include:

• Antiflu - powder, tablets containing phenylephrine, paracetamol, chlorphenamine;
• Grippostad - analgesic granules for the preparation of a solution based on paracetamol, vitamin C;
• Coldrex - tablets, syrup, powder containing caffeine, ascorbic acid, phenylephrine, terpinhydrate, paracetamol;
• Coldact Flu - capsules and suspensions based on paracetamol, phenylephrine, chlorphenamine;
• Panadol - antipyretic tablets containing paracetamol;
• Solpadeine - antipyretic tablets, capsules based on paracetamol, codeine, caffeine;
• TeraFlu - flu powder containing paracetamol, phenylephrine, pheniramine;
• Fervex - powder based on paracetamol, vitamin C, pheniramine;
• Efferalgan - effervescent tablets, suppositories and syrup containing paracetamol.

310

Effervescent tablets for adults 30 pcs.