Cheap analogue of klacid. Forms of release of children's medication "Klacid". Side effects that may be caused by the drug "Klacid"

In our time, antibiotics are considered the most effective treatment for diseases that result in the development of drug-resistant bacterial elements. Due to weak immunity, incorrect self-treatment we are sometimes able to bring our body to a very deplorable state - strong inflammatory processes. And only a very effective tool can affect this.

Today, antibiotics can be prescribed for both adults and children. The situation with these drugs worries parents very much, because often the use of such drugs is unreasonable, and children's body tends to get used to certain types of them, which in the end can reduce the physiological protection of the body or become a cause in general total absence immunity. So, in the recipes of many modern doctors very often there is such a medicine as "Klacid". Why is this particular antibiotic so recommended by so many doctors and pediatricians, and how safe is its use? Let's figure it out together.

What is the medicine "Klacid" and what is its cost?

So, as mentioned above, this is which is attributed to both adults and children. When using it, as in cases with other drugs, you need to be extremely careful and take the medicine only as prescribed by your doctor. Self-medication with antibiotics is extremely dangerous. You should always follow the dose of the medicine at the time of administration, indicated in the instructions for the drug.

The antibiotic "Klacid" belongs to the semi-synthetic group of macrolides. It effectively destroys the protein base of bacteria, thus disinfecting the affected inflamed areas. human body. This drug is very effective in the suppression of aerobic and anaerobic microorganisms. Today, this drug is often used by doctors in medical practice, because it is very effective in influencing standard strains of bacteria and their new types that are being identified.

You can buy the medicine "Klacid" in any modern pharmacy retail chain. The average cost of a pack of tablets is six hundred rubles, suspensions - four hundred rubles, vials for the drug - seven hundred rubles.

Here is the price scale for effective antibiotic"Klacid", the price of which varies depending on the content of the active substance in mg. Many patients are not satisfied with the high cost, so they carefully select an analogue of this drug.

You can use analogues cheaper instead of the drug "Klacid", but this does not guarantee such quick effect relief that is observed when taking clarithromycin.

Because this drug works on certain strains of bacteria, it can be used during their direct treatment or in combination with other medicines, often antibiotics, that can affect microorganisms resistant to clarithromycin more effectively.

Doctors often prescribe two antibiotics due to their 100% effect on various bacteria that cause inflammatory processes with complications.

Pharmacological properties of the drug

The active substance clarithromycin, which contains the antibiotic Klacid, is by far the most effective in terms of destroying harmful microorganisms that are resistant to standard types of antibiotics.

The list of bacteria affected by the drug includes the following: staphylococci, streptococci, gonorrhea, Listeria monocytogenes, Legionella pneumophila, Mycobacterium kansasii, Mycobacterium fortuitum, Chlamydia pneumoniae (TWAR). Their large list is always indicated in detail in original instructions to the drug.

When taking this medication, the physiological state of patients often does not worsen, it remains stable even after the prescribed course of treatment for several days, despite the complexity of the course of the disease.

The course of treatment with the antibiotic "Klacid" can last from three to fourteen days. As with other drugs, the doctor weighs the pros and cons of taking a powerful drug, especially when prescribing it to a child.

This medicine is used during the treatment of infections of the lower parts respiratory tract. It is advisable to take the drug in acute cases of bronchitis and pneumonia of the lungs. A very effective remedy in the treatment of infections of the upper respiratory tract and ENT organs, it is often prescribed for pharyngitis, tonsillitis, laryngitis and sinusitis. Skin infections, especially those developing in soft tissues, are also amenable to treatment with this antibiotic. They are treated with folliculitis, leprosy, erysipelas, inflammation subcutaneous tissue.

Effective drug in the treatment of ulcers duodenum, and very often it is prescribed to HIV-infected patients. Indispensable is the medicine "Klacid" in the fight against syphilis.

This remedy is helpful in the destruction of localized, odontogenic and disseminated infections.

The drug "Klacid" for children is often prescribed for acute otitis media, whooping cough, scarlet fever. Complex inflammatory purulent processes in the throat are no exception.

The medicine "Klacid" for angina is prescribed only with confidence in its bacterial origin.

Antibiotic formulations for adults

Klacid tablets are intended for use by adult patients. The manufacturer carefully approached the issue of dosing the drug. You can meet him in pharmacies in the form of tablets of 250 mg, called "Klacid SR" - 500 mg each, a powdered mass for preparing a solution for intravenous administration using a dropper containing 500 mg of clarithromycin in one dose.

So, tablets and a solution for drip administration are forms that are designed for adults to take an antibiotic. In deciding which type of this medicine to prescribe, the doctor is guided primarily by the complexity of the diagnosis made to the patient.

Forms of release of children's medication "Klacid"

Antibiotics prescribed for children are in the form of a dry powder, which is diluted with boiled water. warm water to obtain a suspension. It is taken in the proportions indicated in the instructions. The drug in question is no exception. The drug "Klacid" is prescribed for children in the form of a fruit powder, which is easy to dilute in a few minutes, preparing a suspension with a pleasant aroma and sweet taste.

In pharmacies you can find bottles of 30-60 ml or 100 ml.

The packaging always contains a measuring spoon, cup or syringe. You can buy an antibiotic in the form of a powder with a concentration of the active substance of 125 mg or 250 mg per 5 ml.

Auxiliary components that are included in the composition of the antibiotic for children - Castor oil, hypromellose phthalate, citric acid, fruit flavor, carbomer, povidone K90, sucrose.

The diluted suspension solution is stored for only two weeks. Therefore, you must always write the date of dilution of the powder on the bottle and follow proper storage the resulting medicine.

Before taking the vial with the contents is thoroughly shaken, as the mixture may precipitate.

Despite the fact that the dosage for the Klacid drug is indicated in the instructions, the doctor can adjust it depending on the diagnosis of the patient and the reaction of his body to potent drugs. This medication should only be prescribed by a doctor. No self-activity in the treatment of any drugs ends well.

At what age is the antibiotic "Klacid" attributed to children? Instructions for use states that the drug in the form of a suspension can be given to babies as early as six months of age. But once again we repeat - only with the instructions of a doctor.

The medicine "Klacid 250" (suspension) is prescribed for older children. Also, the concentration of clarithromycin depends on the severity of the course of the disease. And the suspension "Klacid 125" is suitable for the treatment of the smallest patients.

Diluted antibiotic powder is prescribed until the age of three. Tablets "Klacid" can not be cracked, they must be swallowed. But children, due to their small age and inability to take medicines, cannot cope with this task, so the manufacturer focused on the production of the powdered form of the antibiotic, which most young patients like with its pleasant taste and aroma.

Today, doctors' prescriptions may contain the simultaneous administration of two antibiotics - Flemoxin + Klacid. This moment raises many questions from parents. Why take two antibiotics at the same time? And this is done with complications in order to simultaneously affect the bacteria, which can be detrimental to the drug "Klacid", and those that clarithromycin cannot destroy.

The use of the drug "Klacid" is contraindicated along with such drugs as "Astemizol", "Pimozide", "Cytopride", "Terfenadin", "Ergotamine", "Dihydroergotamine", "Midazolam".

It is unacceptable to take this antibiotic in cases of ventricular arrhythmia and tachycardia. The drug is also contraindicated in severe liver failure and against the background of renal failure.

It is also unacceptable to take this medicine in cases of cholestatic jaundice in history, the cause of which is precisely the use of clarithromycin.

Hypersensitivity to the components of this drug is also the basis for refusing to use it during treatment.

It is possible to use this drug, but with great caution and assessing all the risks of side effects, with moderate renal and heart failure.

If this drug is contraindicated, then doctors carefully select a more gentle analogue, "Klacid" in this case not used.

Antibiotics and pregnancy

Women in position should be wary of taking any medication, whether it be potent drugs or ordinary herbal nasal drops. The components contained in the composition of modern drugs can cause unexpected reactions.

Taking an antibiotic, especially during the development of the fetus in the womb, should be indicated by a competent doctor who, depending on the diagnosis, can foresee the development of the situation.

As for the potent antibiotic agent Klacid, it is generally forbidden to use it during " interesting position". This moment should be remembered forever. Antibiotics are no joke!

Side effects that may be caused by the drug "Klacid"

All potent antibiotics and not only should be treated as a one-time remedy for alleviating general physiological state during the flow complex ailments. Despite the high efficiency of the drug, it has and negative side. What kind of medicine "Klacid" can provoke side effects during the treatment of ailments indicated in the instructions for use of the drug?

So, potent substance may cause allergic reactions in the form of rash, dermatitis, urticaria, skin itching. When taking the antibiotic "Klacid", headaches, loss of consciousness, dizziness and insomnia, anxiety and drowsiness, irritability, confusion, disorientation, depression and apathy, hallucinations, paresthesia are possible.

Often, many patients when taking this medicine experience increased sweating, hemorrhages. Many lose their appetite and develop anorexia.

Frequent reactions to the drug are vomiting, nausea, diarrhea, abdominal pain, stomatitis, constipation and bloating, dryness in oral cavity, hepatitis, jaundice. If such signs make themselves felt, you should immediately stop taking the antibiotic and take a course of therapy prescribed by your doctor.

There are also frequent cases of exacerbation of asthma, nosebleeds, pulmonary embolism.

Many who have taken this drug at least once complain about the change taste sensations when eating. Some patients lose their hearing acuity.

The above defects can manifest themselves in a complex variant in HIV-infected people.

That is why this drug should be treated with full understanding, you need to know what it is, especially if it is prescribed to children. A potent antibiotic can replace a less effective analogue. "Klacid" should be used only as directed by a specialist, so as not to harm either one's own physical condition nor the health of their children. This also applies to drugs replacing this drug.

The use in medical practice of the expensive Klacid (analogues are twice cheaper) is fully justified by the fact that standard antibiotics cannot cope with the influx of more and more new bacteria.

What to do in case of drug overdose?

Very often, especially during the treatment of children, parents do not pay due attention to the dosage of the medicine. Yes, and many adults, switching to treatment strong drugs, not using them early, can harm themselves by doubling the dose on their own with the idea that it will help better. But you can’t joke with antibiotics, because an overdose can even lead to death!

This issue is relevant today more than ever. Whether the analog is taken, "Klacid" itself, in many cases their overdose is observed. Especially such situations are frequent at the time of the first appointment of drugs. The causes of overdose are the negligence of patients, non-compliance with the prescriptions of the attending doctor and inattention when reading the instructions for the drug.

Symptoms of an overdose are very similar to such as nausea, vomiting, general weakness, changes in mental state, chills.

The main method of dealing with an overdose of this drug is to clean the gastrointestinal tract from the components of the drug. You can do this at home with the help of absorbent agents - activated carbon and Atoxil powder.

Acceptable analogues of the antibiotic "Klacid"

So, the new kind a drug can affect a large number of bacteria, but its only drawback compared to the benefits it brings is the cost. In pharmacies, the price of a broad-spectrum antibiotic "Klacid" reaches eight hundred rubles. However, a competent treating doctor will never prescribe a drug without being convinced of the diagnosis itself. After all, this medicine acts only on the bacteria of infectious infections indicated in the instructions.

With a correctly diagnosed diagnosis, an analogue can also be used. "Klacid" at bacterial sore throat can be replaced by the antibiotic Penicillin, as well as its improved forms - powder for diluting the Amoxiclav suspension, Amoxicillin capsules, Solutab and Flemoxin tablets, Augmentin syrup. The reception of the described medicine takes place in severe cases of diseases and in cases where the above analogues do not give any effect.

If you are not satisfied with the price of the Klacid antibiotic, it is always possible to pick up analogues. But it will be the same from them positive effect, as from the drug discussed in this article, only a doctor can argue.

An analogue (“Klacid” has several of them) is selected according to pharmacological properties medicines. So, very often, instead of this drug, antibiotics based on clarithromycin are used, such as Klabaks or Klarbakt, Ecositrin, and Clerimed tablets.

There is also an analogue of this medicine on sale in pharmacies, which is called Clarithromycin, that is, the antibiotic Klacid is identical in active ingredient, its cost does not exceed two hundred rubles. Many people have a question about why doctors do not attribute it to him, and the emphasis is on an expensive drug. The answer has one explanation. The antibiotic "Klacid" is a high-quality foreign-made medicine, while the medicine "Clarithromycin" is often a fake, containing less active ingredient than the original. Therefore, in order to achieve a 100% therapeutic effect, doctors focus on the Klacid remedy, although they do not exclude the use of similar, cheaper drugs.

So, having considered all the properties of the new antibiotic, you understand why today it has won the trust of many doctors and is so often found in their prescriptions.

Despite many positive properties, take it strictly as prescribed by the doctor during infectious complications that cannot be treated with standard medicines. Frequent "friendship" with antibiotics can play a cruel joke with the formation of immunity as such. So be careful about the medicines that are prescribed to you and your children, regardless of age. And in no case do not buy them at your own discretion without visiting a doctor.

Thank you

Klacid represents antibiotic from the group macrolides, which has a detrimental effect on a wide range of pathogenic and conditionally pathogenic microorganisms. The drug is used to treat infectious and inflammatory diseases of various organs and systems, provoked by antibiotic-sensitive microbes. Since microorganisms sensitive to the action of an antibiotic, as a rule, provoke infectious and inflammatory diseases certain bodies, then Klacid is used to treat precisely these organ structures. Most often, an antibiotic is used to treat bronchitis, pneumonia, pharyngitis, tonsillitis, sinusitis, folliculitis and erysipelas.

A distinctive feature of Klacid is its activity against a wide range of microbes, including atypical pathogenic bacteria that cause infectious and inflammatory diseases of the respiratory tract. In addition, the antibiotic has high efficiency in the treatment of acute otitis media, acute bronchitis, pneumonia, pharyngitis or tonsillitis in children.

Varieties, names, composition and forms of release

• Klacid;
• Klacid SR.

Klacid SR is available in a single dosage form - these are tablets of prolonged (long-term) action, and Klacid - in three dosage forms, such as:

• Lyophilisate for solution for infusion;
• Powder for suspension for oral administration;
• Pills.

In everyday life, various dosage forms, varieties and dosages of Klacid are called short and capacious names, reflecting their main characteristics. So, tablets are often called Klacid 250 or Klacid 500, where the number next to the name reflects the dosage of the drug. Suspension, taking into account the same principle, is called Klacid 125 or Klacid 250, etc.

Tablets of both dosages Klacid and prolonged action Klacid SR have the same biconvex, oval shape and are covered with a yellow-colored shell. Tablets are available in packs of 7, 10, 14, 21 and 42 pieces.

Powder for suspension for oral administration is a small granules, painted white or almost white in color and having a fruity odor. The powder is available in 42.3 g vials, complete with dosing spoon and syringe. When the powder is dissolved in water, an opaque suspension is formed, colored white and having a fruity aroma.

Lyophilisate for solution for infusion is available in hermetically sealed vials and is a white powder with a slight aroma.

Therapeutic action of Klacid

Klacid has a wide spectrum of action and harmful to the following types of microorganisms:

• Chlamydia pneumoniae (TWAR);
• Chlamydia trachomatis;
• Enterobacteriaceae and Pseudomonas;
• haemophilus influenzae;
• Haemophilus parainfluenzae;
• Helicobacter (Campilobacter) pylori;
• Legionella pneumophila;
• Listeria monocytogenes;
• Moraxella catarrhalis;
• Mycobacterium leprae;
• Mycobacterium kansasii;
• Mycobacterium chelonae;
• Mycobacterium fortuitum;
• Mycobacterium avium complex (MAC) - a complex including: Mycobacterium avium, Mycobacterium intracellulare;
• Mycoplasma pneumoniae;
• Neisseria gonorrheae;
• Staphylococcus aureus;
• Streptococcus pneumoniae;
• Streptococcus pyogenes.

With regard to the following microorganisms, it is detrimental the action of Klacid is shown only during laboratory tests, but not confirmed by clinical practice:

• Bacteroides melaninogenicus;
• Bordetella pertussis;
• Borrelia burgdorferi;
• Campylobacter jejuni;
• Clostridium perfringens;
• Pasteurella multocida;
• Peptococcus niger;
• Propionibacterium acnes;
• Streptococcus agalactiae;
• Streptococci (groups C, F, G);
• Treponema pallidum;
• Viridans group streptococci.

Indications for use

• Lower site infections respiratory system(bronchitis, pneumonia, bronchiolitis, etc.);
• Infections of the upper respiratory system (pharyngitis, tonsillitis, sinusitis, otitis media, etc.);
• Infections of the skin and soft tissues (folliculitis, erysipelas, infectious cellulitis, furunculosis, impetigo, wound infection etc.);
• Infections caused by mycobacteria;
• Prevention of infection caused by the Mycobacterium avium complex (MAC) in HIV-infected people;
• Eradication of H. pylori to cure gastritis and peptic ulcer of the stomach or duodenum;
• Treatment and reduction in the frequency of recurrence of duodenal ulcers;
• Infections of the teeth and oral cavity (tooth granuloma, stomatitis, etc.);
• Infections caused by Chlamydia trachomatis, Ureaplasma urealyticum (urethritis, colpitis, etc.).

Instructions for use

Klacid suspension (Klacid 125, Klacid for children) - instructions for use

From the powder in the vial, a suspension should be prepared immediately at the moment when it is planned to be used. This is because finished suspension can be stored for only 2 weeks, after which the drug should be discarded, even if it was not completely used. If treatment continues for more than two weeks, then every 14 days the remains of the old suspension should be discarded and a new one should be prepared. The suspension should be stored only at room temperature from 15 o to 30 o C, and shake well before each use.

To prepare a suspension the vial must be carefully opened. After that, add pure non-carbonated water to the mark and shake the vial vigorously to form a homogeneous, opaque white solution. If a powder with an active substance concentration of 125 mg / 5 ml was used, then after adding water, 60 ml of suspension will be obtained. If a powder of 250 mg/5 ml was used, then 100 ml of a ready-to-use suspension will be obtained.

Suspension Klacid is recommended for use in children, as it is easy to dose in required quantity. However, if necessary, adults can also take Klacid in the form of a suspension, measuring the appropriate dosage. But for adults it is more expedient to take Klacid tablets, because. the suspension will be used very quickly and several vials will be needed for the course of treatment, which, in the end, will lead to rather high unnecessary costs.

From the age of 12, provided that the body weight of a teenager is 40 kg or more, it is recommended to give Klacid tablets already.

The suspension can be taken regardless of food, at any time. convenient time. The right amount suspensions should be measured with the supplied dosing spoon or syringe. The suspension is given to children in pure form, however, if they do not like the taste, then you can drink it with water, juice, tea, milk or another drink. For infants, the suspension can be mixed into milk, formula or water.

The dosage of Klacid suspension for children depends on the type of microorganism that caused the infectious disease, as well as on body weight. So, for the treatment of infections in children caused by mycobacteria, there are one dosages of Klacid, and for diseases provoked by any other microbes, other doses of the antibiotic are taken.

So, for the treatment of infections caused by non-mycobacteria, a single dosage of Klacid for children is calculated individually, based on the ratio of 7.5 mg per 1 kg of weight. The drug in the calculated dosage is given to the child 2 times a day. It must be remembered that the dosage is individually calculated only for children weighing less than 40 kg. If a child weighs more than 40 kg, then he is given Klacid in dosages for adults.

Consider, for example, the calculation of the dose of the drug for a child weighing 20 kg. A single dosage of Klacid for a child weighing 20 kg is 20 kg * 7.5 mg = 150 mg. This means that the child must be given 150 mg of Klacid 2 times a day. Now it is necessary to calculate how many milliliters of the suspension should be given to the child so that he receives the necessary 150 mg of the active substance. We will calculate for a suspension with a concentration of 125 mg / 5 ml. To do this, we make a proportion as follows:
125 mg - 5 ml
150 mg - X ml,
where the top line indicates the concentration of the suspension (125 mg of the active substance is contained in 5 ml). Further, in the bottom line, under the number indicating the content of the active substance in a certain volume of suspension (in our example, this is 125 mg), we write how much of this substance should be given to the child (in the example, this is 150 mg). And under the indication of the volume in the first line (in the example it is 5 ml), in the second we write X, since we need to calculate how many milliliters of the suspension contains the required 150 mg of the active substance. Next, we write an equation for calculating the value of X, which looks like this:
X = 150 mg * 5 ml / 125 mg = 6 ml.
This means that a child with a body weight of 20 kg should be given 6 ml of suspension at a concentration of 125 mg / 5 ml 2 times a day.

Similarly, the amount of suspension and the required dosage for children with any body weight are calculated. This algorithm can be used as a template by simply substituting your own data into it. In proportion, if we are talking about a suspension with a concentration of 250 mg / 5 ml, in the first line they write not "125 mg - 5 ml", but "250 mg - 5 ml".

In addition, you can not calculate the individual dosage each time, but use the following table, which shows the approximate average doses for children with different body weights.

Dosage of Klacid for children suffering from diseases caused by mycoplasmas, is also calculated individually, based on the ratio of 7.5 - 15 mg per 1 kg of weight, 2 per day. The calculated daily dose is also given 2 times a day. In principle, dosages for the treatment of mycoplasmal diseases can not be calculated, but use the table above, which indicates the amount of suspension, the child needs with one or another body weight, based on the calculation of 7.5 mg per 1 kg of weight. You just need to remember that this table indicates the minimum dosage for the treatment of mycoplasmal infections, and they can be increased by a maximum of two times. For example, a child weighing 20 kg for the treatment of non-mycoplasmal infection should be given 150 ml of a suspension with a concentration of 125 mg / 5 ml 2 times a day. This means that a child weighing also 20 kg, but for the treatment of mycoplasmal infection, you need to give 150-300 ml of a suspension with a concentration of 125 mg / 5 ml 2 times a day.

The maximum allowable daily dosage of Klacid for children weighing less than 40 kg for the treatment of any infections is 500 mg per day.

Taking Klacid with ergotamine or dihydroergotamine can cause the development of toxic effects of the latter, which are expressed in spasm peripheral vessels and hypoxia of various organs and tissues, including the central nervous system.

Taking Klacid with Colchicine enhances the effect of the latter.

Taking Klacid with aminoglycoside antibiotics (for example, Levomycetin, etc.) increases the risk of hearing complications, since both drugs are ototoxic.

Klacid for children

Rules for the use and dosage of the suspension and tablets Klacid for children are given in the relevant subsections of the instructions for use.

Side effects

1. Nervous system:

• Dizziness;
• Drowsiness;
• Dyskinesia (dysmotility of various organs, for example, the gallbladder, etc.);
• Anxiety;
• Excitability;
• psychotic disorders;
• confusion;
• Depersonalization;
• Disorientation;
• Nightmares;
• Paresthesia (feeling of running "goosebumps", numbness of the limbs);
• Mania.

• Rash on the skin;
• Anaphylactic reactions;
• bullous dermatitis;
• itchy skin;
• Angioedema;
• Stevens-Johnson syndrome;
• Toxic epidermal necrolysis;
• DRESS syndrome (skin rash, increased amount eosinophils in the blood).

• Increased sweating;
• Hemorrhages (pinpoint hemorrhages).

• kidney failure;
• Interstitial nephritis.

• Anorexia;
• Hypoglycemia ( low level blood glucose).

• Spasm in the muscles;
• musculoskeletal stiffness;
• Rhabdomyolysis;
• Myopathy.

• Vomit;
• Nausea;

Sometimes, in the treatment of a disease, one or another drug for some reason may not be suitable. In this case, you have to look for a substitute.

What is Klacid

Klacid belongs to a number of macrolides. This series is about safe drugs antibiotic action. Such medicines are prescribed by specialists for the treatment of the following diseases:

• respiratory diseases (bronchitis, pneumonia);
• erysipelas;
• some diseases of the skin of soft tissues;
• mycobacterial infections;
• peptic ulcer of the stomach, gastritis;
• sinusitis;
• pharyngitis.
  This remedy is suitable for the treatment of adults, as well as children over 12 years of age.

The main active ingredient in Klacid is clarithromycin. It disrupts the process of protein synthesis in bacteria, which leads to its destruction.

The drug has a wide range action, it has low toxicity. However, this medicine is made in the USA, so it has a significant drawback - a high price. In addition, it is not always possible to find it in pharmacies. Therefore, you should pay attention to drugs that have a similar effect.

1. Ergot preparations.
2. Any statins.
3. Colchicine.
4. Ranolazine.
5. Ticagrelor.
6. Astemizol.
7. Cisapride.
8. Pimozide.
9. Terfenadine.

The antibiotic Klacid should not be given to children in the form of tablets. If necessary, it can be recommended for use in the form of a suspension.

Patients with ischemic heart disease, with renal and hepatic insufficiency, as well as pregnant women, should take precautions when taking Klacid.

You can not take this drug together with and anticoagulants.

Sometimes the main component in the composition of Klacid can provoke allergic reactions. Therefore, the doctor may prescribe a drug with a similar effect, but from among the cephalosporins. These drugs include Suprax, Cephalexin, Ceftriaxone. If there is intolerance to the individual components of Klacid, then drugs containing amoxicillin may be prescribed for treatment. These are Ospamox, Cobol, Flemoxin, etc.

Any analogue of Klacid should be selected by a doctor, taking into account individual characteristics each individual patient.

Substitutes for Klacid

There are many antibiotics with different spectrums of action. This drug has a number structural analogues for the active substance. The following are the best substitutes Klacida.

Clarithromycin

A much cheaper drug than Klacid, but no less effective. It is based on the same active ingredient. It has the same indications for use.

Be aware that clarithromycin can also be used to treat peptic ulcer stomach, but only as part of complex therapy.

Clarithromycin-Teva

The drug has all the properties of a group of antibiotics in this series. It is prescribed for the treatment of such ailments:

• all types of bronchitis;
• sinusitis;
• pneumonia;
• pharyngitis;
• wound infections;
• furunculosis;
• genital infections (ureaplasmosis, chlamydia);
• peptic ulcer of the stomach.

The list of contraindications is quite voluminous, as with any drug with an antibiotic effect.

Clarithromycin-OBL

It is also intended for the treatment of various inflammatory diseases of the ENT organs, as well as the respiratory organs. Do not use for people with hypersensitivity to clarithromycin or other components of the drug, it is not recommended for use by pregnant women and children under 12 years of age, as well as patients with liver and kidney problems.

Wilprafen

It also belongs to the group of macrolides, however, the main active ingredient in the composition is josamycin. Has a huge spectrum of action.

Vilprafen does not negative influence on the intestinal microflora, which distinguishes it from other antibiotics.

It is often used in the treatment of diseases of the ENT organs, namely:

1. Tonsillitis.
2. Paratonsillitis.
3. Scarlet fever.
4. Diphtheria.
5. sinusitis.
6. Laryngitis.
7. Otitis.
8. Whooping cough.

Often used in dental practice for the treatment of gingivitis, stomatitis, pericoronitis. Also used as part of therapy in the treatment of diseases of the skin, infections urinary tract. Cannot be used in the treatment of premature babies. The duration of treatment with the drug depends on the diagnosis, as well as on the severity of the disease.

Fromilid

This analogue of Klacid is used in the treatment various forms pneumonia, as well as bronchitis, tonsillopharyngitis, otitis media, sinusitis. The instructions for the drug lists a number of contraindications for its use.

The advantage of the drug is the possibility of taking it in granules for children over the age of 6 months.

Fromilid UNO

Prolonged action drug. It is absorbed and absorbed more slowly, however, the effect of the drug lasts much longer.

Klacid SR

It is also a semi-synthetic macrolide antibiotic. It penetrates well into the tissues of the body, providing fast action. It can be used as an analogue of Klacid for the treatment of children under the age of 12, however, the dosage of the drug is prescribed exclusively by a doctor.

Klabaks

It easily penetrates into the tissues of the body, so it acts quickly enough.. The spectrum of action is very similar to Klacid.

The instructions for the product indicate which drugs it should not be taken at the same time, so before purchasing the product, you must carefully study the instructions. The drug has an impressive list of side effects.

drug with good therapeutic effect, is successfully used in the treatment of severe forms of respiratory diseases, with uncomplicated skin inflammations. It is also prescribed for gastric and duodenal ulcers, as well as in the treatment of chlamydia. It is strictly contraindicated in case of hypersensitivity to clarithromycin, porphyria, it is prescribed with caution to pregnant and lactating women. During treatment with Klabaks should be discontinued. breast-feeding baby, if any.

Contraindications for Klabaks are the same as for Clarithromycin.

Binocular

The use of the drug during pregnancy is possible only in case of urgent need. The drug has a large number of side effects, they are indicated in the instructions for this tool. Do not use simultaneously with certain drugs (ergot derivatives, cisapride, terfenadine).

Clarithrosin

This drug is prescribed for the treatment of respiratory infections, as well as various bacterial infections, purulent inflammation skin, gastric ulcer. Like most other antibiotics, it should not be taken by children, pregnant and lactating women, as well as patients with kidney and liver problems, people who are hypersensitive to the components of this medicine.

Clarexide

Included in the group of antibiotics containing clarithromycin.

The main active ingredient easily penetrates not only into all tissues of the body, but also into breast milk, therefore, during the period of treatment with this remedy, it is necessary to stop breastfeeding.

Claromin

The main active ingredient is also clarithromycin. It is prescribed for diseases of the upper and lower respiratory tract. It has the same contraindications as all drugs in this group. Women should only use Claromine during pregnancy if there is no alternative treatment available.

Ecositrin

This analogue of Klacid is produced in Russia, so it costs much less.

The duration of treatment with this remedy is about 2 weeks, if necessary, the drug can be taken for six months.

However, this is done with short interruptions and exclusively as directed by a specialist. It helps in the treatment of pneumonia, tonsillitis, sinusitis.

Deals with skin infections may be given in combination with other antibiotics. Among the standard list of contraindications, there is also porphyria.

Sumamed

This drug also belongs to macrolides and is similar to Klacid in terms of therapeutic effect However, Sumamed has another active ingredient - azithromycin. This remedy is also used to treat genital infections. One tablet per day is taken, which is certainly convenient. However, it should be remembered that the antibiotic should not be washed down with milk. Also, it should not be taken with food. When choosing which is better, Klacid or Sumamed, you should remember that different drugs can provide different action on different people.

The basic rule that you should always remember is that you cannot use any antibiotics without a doctor's prescription.

The antibiotic Klacid contains an active ingredient, as well as additional components: sodium calcium alginate, sodium alginate, lactose, anhydrous hydrogen phosphate citric acid, stearic acid, povidone KZO, magnesium stearate.

Release form

Klacid 500 mg and 250 mg is produced in the form of tablets, which are coated with a yellow shell. The tablets are oval in shape, the presence of two layers is noted along the cut: a yellow film and a whitish core. A blister made of foil can hold 7, 10 or 14 tablets, 1, 2 or 3 such blisters are packed in a cardboard box.

pharmachologic effect

Active substance clarithromycin belongs to the group of macrolides, semi-synthetic. The antibacterial effect is produced by suppressing the bacterial protein synthesis. The consistency of the tablet is such that the active ingredient is released gradually as the drug passes through the gastrointestinal tract. Clarithromycin active against isolated and standard cultures of bacteria. A high effect is noted when using the agent for the treatment of legionnaires' disease, pneumonia of mycoplasmal etiology. Gram-negative bacteria are not sensitive to clarithromycin .

The active substance acts as an antibacterial agent against group A streptococci , pneumococcus , golden staphylococcus , microorganism pathogens hemophilic infection , listeriosis , pneumonia , pneumochlamydiasis , leprosy , , faces , sporotrichosis.

Those pathogens that do not show sensitivity to and Methicillin , are also resistant to clarithromycin .

Also noted positive impact clarithromycin in relation to the following microorganism (efficacy and safety not confirmed in the process clinical research): viridescent streptococcus, peptococcus, group B, C, F, G streptococci; causative agents of pasteurellosis in birds, human toxicoinfections, , borreliosis, enterocolitis.

During the metabolism clarithromycin the body releases active 14-hydroxyclarithromycin, which exhibits microbiological activity. Metabolism occurs in the human liver. If a person took the drug regularly, there was no increase in the activity of its influence.

Pharmacokinetics and pharmacodynamics

Substance clarithromycin binds well to blood proteins. The highest concentration of the drug is determined within 6 hours. The larger the dose of the drug taken by the patient, the longer the period of time it is excreted from the body. The amount of the metabolite (14-hydroxyclarithromycin) does not increase in parallel with an increase in the dose of clarithromycin. The greater the accepted dose of Klacid, the less 14-hydroxyclarithromycin is formed in the body.

The drug is excreted from the body through the kidneys and intestines (respectively, 40% and 30% of the dose). After oral administration, clarithromycin and its metabolite are distributed to tissues and body fluids, tissues typically contain twice as much drug as serum.

Dosage adjustment is not required for liver diseases. With kidney disease, the elimination period clarithromycin from the body increases. Also, the elimination period of the drug increases in the elderly.

Indications for use

The use of the drug Klacid is indicated for the following diseases and conditions:

• infectious diseases of the respiratory tract, lower sections ( pneumonia , and etc.);
• infectious diseases of the respiratory tract, upper divisions(at , etc.);
• infectious lesions of soft tissues, skin ( folliculitis , erysipelas and etc.);
• mycobacterial infections caused by Mycobacterium intracellulare and Mycobacterium avium;
• infections provoked by Mycobacterium fortuitum, Mycobacterium chelonae, Mycobacterium kansasii.

It is also practiced to take the remedy to prevent infection provoked by the Mycobacterium avium complex (MAC). It is prescribed to reduce the frequency of manifestations of recurrences of duodenal ulcers.

Contraindications

Do not take an antibiotic in the following cases:

• with the body to the means of the macrolide group;
• at porphyria ;
• during pregnancy And breastfeeding ;
• children up to 3 years of age.

Carefully, the remedy is prescribed for violations of the kidneys and liver.

Can't be taken at the same time clarithromycin and such medicines: Dihydroergotamine , pimozide , Erhotamine , Astemizol .

Side effects

If Klacid IV is administered or oral intake means, a number of side effects are possible. If such effects occur after intravenous administration or oral administration of tablets, it is necessary to inform the specialist about this. The following manifestations are possible:

• CNS functions : change palatability, .
• Digestive system : nausea , stomach ache, .
• Local reactions with the introduction of the solution : inflammation at the injection site, phlebitis , pain during palpation.
• Laboratory indicators : increased activity of liver enzymes.

In addition to these side effects, side effects that occur less frequently are possible:

• oral cavity;
• thrombocytopenia , leukopenia ;
• hypoglycemia ;
• mental disorders,;
• , convulsions ;
• myalgia ;
• reversible hearing loss;
• ventricular;
• stomatitis , spicy , ;
• liver dysfunction;
• increased levels of creatinine in the blood.

Instructions for use Klacid (Method and dosage)

Instructions for the use of Klacid for children and adults provide for oral administration, regardless of the meal.

Adult patients are shown taking 250 mg of clarithromycin twice a day. If severe diseases, mycobacterial infections are being treated, the dose may be increased to 500 mg twice a day. In most cases, treatment lasts from 5 to 14 days.

If prescribed for treatment suspension Klacid instructions for use must be followed exactly. The suspension is prescribed for the treatment of children, it can be taken regardless of food intake, it can be taken with milk. To prepare the suspension for use, you need to gradually add water to the vial to the mark, then shake. 5 ml of a 60 ml suspension contains 125 mg of clarithromycin; 5 ml of a 100 ml suspension contains 250 mg of clarithromycin. The suspension can be stored for two weeks at room temperature.

Before giving the antibiotic Klacid to children, you need to shake the suspension thoroughly. A day is recommended for children to use a dose of 7.5 mg per 1 kg of body weight twice a day. The highest allowable dose is 500 mg twice a day. Therapy can last from 5 to 10 days.

Overdose

When taken very large doses of this drug, patients may show signs of impaired functioning of the digestive system. It is important to remove the remnants of the drug from the gastrointestinal tract as soon as possible, after which symptomatic treatment is carried out.

Interaction

Combination is strictly not allowed. clarithromycin and drugs Astemizol , pimozide , Terfenadine , Cisapride , as in this case, the development of serious side effects is likely. In particular, the manifestation of cardiac arrhythmias, including ventricular fibrillation, ventricular tachycardia, is possible.

Concomitant use of clarithromycin and Ergotamine or probably acute poisoning with ergotamines. In particular, ischemia of the extremities, vascular spasm, etc. may occur. Simultaneous administration of clarithromycin and ergot alkaloids is not allowed.

CYP3A inducers induce the metabolism of clarithromycin. As a result, the concentration of clarithromycin and its effectiveness decreases. If clarithromycin is used concomitantly, the plasma concentration increases Rifabutina and the concentration of clarithromycin decreases.

Preparations Nevirapine , Efavirenz , Rifabutin , Rifapentine able to accelerate the metabolism of clarithromycin, thereby reducing its plasma concentration and increasing the concentration of its metabolite - 14-OH-clarithromycin. As a consequence, therapeutic efficacy may decrease.

Decreased concentration clarithromycin observed when taken together with etravirine .

It is necessary to adjust the dose of drugs when co-administered clarithromycin and ritonavir .

With simultaneous treatment with Klacid and oral hypoglycemic drugs or insulin, severe hypoglycemia may occur. Glucose levels should be constantly monitored.

When taking antibiotics concomitantly with quinidine , disopyramide possible ventricular tachycardia.

With caution, clarithromycin should be taken by those who receive drugs - substrates of the CYP3A isoenzyme, as well as in combination with statins.

Concomitant treatment with clarithromycin and is contraindicated.

It is important to monitor the patient's condition during joint treatment and clarithromycin due to the risk of bleeding.

When taking clarithromycin and , there is a need to reduce the dosage of the latter drugs.

Simultaneous treatment with antibiotics and or carbamazepine leads to an increase in the concentration of these drugs in the bloodstream.

When using clarithromycin and triazolam likely to affect the central nervous system, as a result, drowsiness and confusion develop.

People who have impaired liver or kidney function should not take clarithromycin and colchicine at the same time.

With simultaneous treatment with clarithromycin, the effect of the latter is enhanced. Required constant control serum digoxin levels.

There is a bidirectional effect of drugs while taking clarithromycin and atazanavir , as well as clarithromycin and itraconazole, clarithromycin and saquinavir .

When treated simultaneously with an antibiotic and, diltiazem increases the likelihood of developing arterial hypotension.

Terms of sale

In pharmacies, the antibiotic is sold by prescription.

Storage conditions

It is necessary to protect the antibiotic from the access of children, it should be stored at a temperature not exceeding 30 ° C.

Best before date

The shelf life of the antibiotic is 3 years.

special instructions

In people with liver disease, there may be a change in the levels of serum enzymes, from which tablets should be prescribed carefully.

Caution is given to people taking other drugs that are metabolized by the liver in parallel.

Prolonged antibiotic treatment may lead to the formation of colonies with big amount insensitive fungi and bacteria.

In chronic liver diseases, serum enzymes should be regularly monitored.

Possible manifestation pseudomembranous colitis during antibiotic treatment. It is also possible to change the normal intestinal microflora.

Caution should be given to people with severe heart failure, bradycardia, hypomagnesaemia. It is necessary to constantly monitor the ECG, determining the increase in the QT interval.

May increase symptoms in people who take clarithromycin.

The powder for the preparation of a suspension of Klacid contains sucrose, which should be taken into account by people suffering.

During treatment with clarithromycin, care must be taken to drive vehicles and perform activities that require high concentration attention.

Synonyms

Clarithromycin

Klacid's analogs

Coincidence in the ATX code of the 4th level:

Klacid's analogues are agents that belong to the same group and have an active substance similar to Klacid. These are medicines Clarexide , Binocular , Claricite , Clarithrosin , Clarithromycin , Claromin etc. You can replace the drug only after the approval of the doctor, since each of these drugs has certain features of use and side effects.

The price of analogues can be either higher or lower. Differences Klacid And Klacid SR in that the latter drug is a prolonged-release drug, that is, the active substance is released more slowly.

With alcohol

According to the instructions, Klacid and alcohol are incompatible. If the patient consumes alcohol during treatment with this antibiotic, the risk of side effects increases dramatically, since the toxicity of the drug greatly increases.

Klacid for children

Klacid for children can be used from the age of three. In most cases, children are prescribed Klacid suspension. Reviews for children indicate that this drug is quite effective. At the same time, the price of the suspension is quite high. The dosage for children is as follows: 7.5 mg of the drug per 1 kg of the child's weight twice a day. The largest daily dose- 500 mg.

Children who are already 12 years old are prescribed 250 mg (tablets) twice a day. There is evidence that children tolerate Klacid more easily than other antibiotics. Therefore, the drug is often prescribed for , bronchitis , pneumonia etc. However, we should not forget that side effects still occur.

During pregnancy and lactation

There is no precise information on the safety of using Klacid for treatment. and nursing mothers. Therefore, the use during the period of gestation is not practiced.

Description of the drug

List of analogues

Note! The list contains synonyms Klacid, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

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Official instructions for use

Klacid ®

INN:

Registration number:

Indications for use:

Contraindications:

Carefully:

Use during pregnancy and during breastfeeding:

Dosage and administration:

Side effect:

Overdose:

Interaction with other drugs:

Special instructions:

Influence on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions:

Leave conditions:

The information on the page was verified by the therapist Vasilyeva E.I.