Paxil appointment. Paxil - instructions for the use of tablets, composition, indications, side effects, analogues and price. Side effects and overdose

Country of origin

Product group

Antidepressant

Release form

• Tablets of 20 mg - 100 pieces per pack. Tablets 20mg - 30pcs per pack.

Description of the dosage form

• White, film-coated, oval, biconvex tablets, debossed with "20" on one side and a break line on the other.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• paroxetine hydrochloride hemihydrate 22.8 mg, which corresponds to the content of paroxetine 20 mg Excipients: calcium dihydrophosphate dihydrate, sodium carboxystarch type A, magnesium stearate. Shell composition: hypromellose, titanium dioxide, macrogol 400, polysorbate 80

Paxil indications for use

• - depression of all types, including reactive depression and severe depression, depression accompanied by anxiety (the results of studies in which patients received the drug for 1 year show that it is effective in preventing relapses of depression); - treatment (including maintenance and preventive therapy) of obsessive-compulsive disorder (OCD). In addition, paroxetine is effective in preventing OCD relapses; - treatment (including supportive and preventive therapy) of panic disorder with and without agoraphobia. In addition, paroxetine is effective in preventing the recurrence of panic disorder; - treatment (including supportive and preventive therapy) of social phobia; - treatment (including maintenance and preventive therapy) of generalized anxiety disorder. In addition, paroxetine is effective in preventing the recurrence of this disorder; - treatment of post-traumatic stress disorder.

Paxil contraindications

• - simultaneous administration of MAO inhibitors and a period of 14 days after their withdrawal (MAO inhibitors cannot be prescribed within 14 days after the end of treatment with paroxetine); - simultaneous reception of thioridazine; - concomitant use of pimozide; - age up to 18 years (controlled clinical studies of paroxetine in the treatment of depression in children and adolescents have not proven its effectiveness, therefore the drug is not indicated for the treatment of this age group). Paroxetine is not prescribed to children under the age of 7 years due to the lack of data on the safety and efficacy of the drug in this category of patients. - hypersensitivity to paroxetine and other components of the drug.

Paxil dosage

• 20 mg 20 mg

Paxil side effects

• The frequency and intensity of some side effects may decrease with continued therapy and usually do not lead to discontinuation of treatment. Determination of the frequency of side effects: very often (> 1/10), often (> 1/100, 1/1000, 1/10 000,

drug interaction

Overdose

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

Paxil analogs are presented, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more identical active substances. When choosing synonyms, consider not only their cost, but also the country of origin and the reputation of the manufacturer.

Description of the drug

In terms of its chemical structure, paroxetine differs from tricyclic, tetracyclic and other well-known antidepressants.

Paroxetine has a weak affinity for muscarinic acetylcholine receptors, and animal studies have shown that it has only weak anticholinergic properties.

In accordance with the selective action of paroxetine, in vitro studies have shown that, unlike tricyclic antidepressants, it has a weak affinity for α 1 -, α 2 - and β-adrenergic receptors, as well as for dopamine (D 2), 5-HT 1 -like, 5HT 2 - and histamine (H 1) receptors. This lack of interaction with postsynaptic receptors in vitro is confirmed by the results of in vivo studies, which demonstrated that paroxetine does not have the ability to depress the central nervous system and cause arterial hypotension.

Pharmacodynamic effects

Paroxetine does not disrupt psychomotor functions and does not enhance the inhibitory effect of ethanol on the central nervous system.

Like other selective serotonin reuptake inhibitors, paroxetine causes symptoms of 5-HT receptor overstimulation when administered to animals that have previously received MAO inhibitors or tryptophan. Behavioral and EEG studies have demonstrated that paroxetine produces weak activating effects at doses in excess of those required to inhibit serotonin reuptake. Its activating properties are not "amphetamine-like" in nature.

Animal studies have shown that paroxetine does not affect the cardiovascular system.

In healthy individuals, paroxetine does not cause clinically significant changes in blood pressure, heart rate and ECG.

Studies have shown that, unlike antidepressants that inhibit norepinephrine reuptake, paroxetine has a much lower ability to inhibit the antihypertensive effects of guanethidine.

List of analogues

Note! The list contains Paxil synonyms that have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

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Official instructions for use

Paxil (PAXIL)

Pharmacological properties

Pharmacokinetics

Indications for use

The drug "Paxil" is currently one of the most popular antidepressant drugs. Our life, filled with all sorts of stressful situations, needs the availability of such medications, sometimes being the only means that can relieve overstrain and put aside our fears, feelings and various phobias. Therefore, now we will analyze such main aspects regarding Paxil tablets: reviews of people, method of use, restrictions, side effects and much more.

Compound

The antidepressant described in this article contains the following elements:

• Main substance: paroxetine hydrochloride hemihydrate in the amount of 22.8 mg.
• Auxiliary components: calcium dihydrogen phosphate dihydrate, magnesium stearate, sodium carboxymethyl starch type A.

The shell of the tablet itself consists of hypromellose, titanium dioxide, macrogol 400 and polysorbate 80.

Implementation form

The tool is available in the form of tablets, which are coated (it comes in various colors). The pills are oval, biconvex, engraved on one side and a break line on the other.

Dragees are produced in blisters, 10 pieces each. Sold in a cardboard box of 10, 30 and 100 tablets.

In what cases should it be applied?

The drug "Paxil" can be prescribed by a doctor for the following problems:

1. Spleen, prostration, depression.
2. Extreme mental disorder.
3. social phobia.
4. post-traumatic disorder.
5. Anxiety of the patient.
6. Panic attacks.

Method of application and dosage

In what quantity and how to drink the drug "Paxil"? Instructions for use of the drug states that it is advisable to take it once a day in the morning, at the time of eating. The pill should be swallowed whole, and there is no need to chew it.

Now consider the dosing regimen of the drug, depending on the mental state of the patient:

Stopping the drug

As with therapy with any other psychotropic drugs, the abolition of Paxil - tablets that are good antidepressants - should be gradual. The scheme for terminating the reception of funds can be as follows:

Dose reduction by 10 mg every 7 days.

After reaching the mark of taking the drug 20 mg per day, the patient should continue to take it in the same volume for 1 week. And only after that the tablets are completely canceled.

However, if symptoms develop at the time of a dose reduction or after the drug has been completely stopped, the doctor may resume taking this medication. In the future, the specialist may continue to reduce the number of pills taken, but more slowly.

To date, there are many similar medicines like Paxil pills. The analogues of this drug are called as follows: tablets "Adepress", "Plezil", "Reksetin", "Sirestill". These drugs have the same composition as the antidepressant described in this article. Currently, there are drugs that are similar in their action to Paxil. Analogues can be easily purchased at any pharmacy, and their composition will be similar. For example, similar drugs for the pharmacological group: Amitriptyline, Oprah, Miracitol, Deprenon, Amiksid, Negrustin, Fluoxetine, Zoloft, Prozac, Cipramil, Stimuloton, Framex, Sedopram, Noxibel, Epivel.

Contraindications

Patients who take MAO inhibitors such as lamizide, thioridazine, tryptophan.

Children under 18 years old.

Women who are breastfeeding their babies.

With increased individual sensitivity to paroxetine and other auxiliary components of the drug.

It is necessary to carefully apply the medication to people who have renal and hepatic insufficiency.

Taking the drug during pregnancy

The drug "Paxil" is prescribed to pregnant women only if the intended benefit to the mother is higher than the risk to the fetus. In any case, the doctor should consider the option of alternative treatment for pregnant women.

Drug use in adolescents

The antidepressant "Paxil" is not prescribed for children, even in the smallest doses. Young people from the age of 18 are prescribed this medication, however, it must be taken into account that at the beginning of such treatment, boys or girls may increase the risk of suicidal tendencies (for example, suicide attempts, thoughts about it). The characteristic hostility of the patient (aggression, anger, irritability, impulsivity) can also be observed. Currently, there is no data on the safety of this antidepressant for adolescents, on its effect on the growth, maturation and behavioral development of boys and girls.

Third Party Effects

None of the similar drugs can not have unwanted reactions, so Paxil is no exception. Side effects when taking this remedy can be as follows:

1. Disorders of the lymphatic system and blood flow:

Hemorrhages in the skin, as well as in the mucous membranes - rarely;

Thrombocytopenia is a pathology associated with a sharp decline in the number of red blood cells (observed sporadically).

2. Metabolic and nutritional problems:

Increased concentration of cholesterol;

Decreased appetite.

3. Mental disorders:

Drowsiness or, conversely, insomnia, nightmares;

Agitation - emotional arousal, accompanied by anxiety, fear, anxiety (a person in this state becomes too fussy, he has a feeling of emptiness, thoughts are confused, the ability to reason is disturbed);

hallucinations;

Thoughts of suicide (such ideas and behaviors may occur early in treatment or after therapy is stopped).

4. Violations of the nervous system:

dizziness, headache, trouble concentrating;

Cramps, restless leg syndrome;

Very rarely - serotonin syndrome, which is characterized by confusion, increased sweating, the appearance of hallucinations, chills and tremors in the body, tachycardia and tremor.

5. Problems with the organs of vision:

Acute glaucoma;

Mydriasis - pupil dilation;

Blurred vision.

6. Violations of the organ of hearing and heart:

The appearance of noise in the ears;

Aggression.

Liver failure (signs of hepatitis and cirrhosis).

Urinary retention.

In case of an overdose, a specialist prescribes the following treatment:

1. Gastric lavage.
2. Taking activated charcoal.
3. Artificial induction of vomiting.

If the case is severe, then the patient can be admitted to a hospital and deal with his further treatment within the walls of the hospital. In a medical institution, he is given various detoxification measures, monitors the work of the heart, and perhaps even connects him to a ventilator (in critical moments).

Medicine Paxil: price in Russia

This drug is manufactured in France, so it is brought to the post-Soviet countries from there, and here its cost depends on the exchange rate, various duties at customs points, delivery and storage costs, and, of course, the mark-up of a particular pharmacy. To date, the average cost of such an antidepressant ranges from 700-730 rubles per package, in which 30 tablets, and 2000-2300 rubles for 100 pills.

Can I drink alcohol during therapy?

From the point of view of therapeutic interaction, Paxil tablets and alcohol are compatible concepts, therefore, purely theoretically, it can be assumed that during treatment you can drink wine, whiskey, etc. However, in practice, doctors do not recommend doing this, since this may lead to are the following adverse effects:

A one-time use of a strong drink on the eve of taking the medicine significantly reduces the effect of the drug.

The systematic intake of alcohol causes an increase in both the positive results of the pills and their side effects.

Influence on the ability to drive a car and other mechanisms

The action of "Paxil" - a new generation antidepressant drug - in no way has a negative effect on the patient's psychomotor functions. However, in the treatment of any other psychotropic drugs, patients should be extremely prudent when driving a car and working with mechanisms.

People evaluation

Unfortunately, there is no unequivocal opinion of patients about the drug Paxil. Reviews are both positive and negative. Good responses were left by those patients who took pills strictly according to the doctor's prescription for the treatment of severe mental disorders. People noted that they gradually managed to achieve results: the state of asthenia disappeared, panic attacks passed, anxiety, fears - all this was eliminated. Patients had faith in the future, as well as the desire to perform some important work. The only thing is that the effect did not appear immediately, you had to wait. And this is a normal phenomenon.

But, of course, there are also negative reviews about the Paxil drug. Reviews of a disapproving nature relate to the allegedly false therapy with this remedy. Many people on the forums write that at the very beginning of taking these pills they really had an excellent effect: a mood appeared, strength and energy increased, depression disappeared, the person felt much better. However, as soon as the drug was stopped, it became even worse, and in addition, various side effects appeared: headaches, nausea, insomnia, etc. It turns out that people developed addiction, a kind of withdrawal, like drug addicts.

Also, the disadvantages of this medication, many people attribute its high cost, because it really is an expensive drug.

Therefore, before thinking about whether it is worth taking these pills at all, maybe it is better to seek help from certified psychiatrists who will help to cope with the problem itself, and not dull its consequences?

Doctors' opinions

Doctors respond positively about the antidepressant Paxil. Reviews of this nature are not accidental: with proper use, this medication is able to cope with its task. Also, unlike many other similar drugs, Paxil is a proprietary drug, so doctors most often prescribe it.

However, experts unanimously warn that this antidepressant must be taken correctly. It is imperative to follow all the prescriptions and prescriptions of the doctor, who sets the individual dosage of the medicine for each individual person. And if the patient turned to a specialist for help and decided to treat his nervous breakdown with this particular medication, then it is necessary, according to the rules, to finish therapy. What is meant? It is necessary to cancel the drug gradually, and not abruptly. And of course, patients should not forget about interactions with other drugs, as well as alcohol. And if the patient complies with all the doctor's prescriptions, then the positive effect of the drug will definitely be.

Terms and conditions of storage

The medicine should be kept out of the reach of children. The storage temperature should not exceed 30 degrees.

The shelf life of the drug is 3 years from the date of manufacture.

Today you have learned enough interesting and necessary information about such a drug as Paxil (price, use, analogues, reviews about it - all this is in the article). We found out that this medicine is a strong antidepressant, so you need to take it only if there are doctor's prescriptions. By the way, only for its intended purpose will a person be sold this remedy in a pharmacy, since such a serious medication is dispensed strictly by prescription.

Release form Paxil

Coated tablets

Packing Paxil

Pharmacological action Paxil

Paxil is an antidepressant. Selectively blocks the reuptake of serotonin, increases its concentration in the synaptic cleft and causes an antidepressant effect. It has a low affinity for muscarinic cholinergic receptors, for alpha-1, alpha-2, beta-adrenergic receptors, as well as 5-HT_1-like, 5-HT_2-like and histamine (H_1) receptors. It does not violate psychomotor functions and does not potentiate the inhibitory effect of ethanol on them. The antidepressant effect appears after 7-14 days of systematic use. Against the background of treatment, there is a decrease in anxiety, depression, normalization of sleep.

Paxil Indications

Depression of all types, including reactive depression, severe endogenous depression and depression accompanied by anxiety (the results of studies in which patients received the drug for 1 year show that it is effective in preventing relapse of depression).
- Treatment (including maintenance and preventive therapy) of obsessive-compulsive disorder (OCD) in adults, as well as in children and adolescents aged 7-17 years (it has been proven that the drug remains effective in the treatment of OCD for at least 1 year and prevention of OCD relapses).
- Treatment (including maintenance and prophylactic therapy) of panic disorder with and without agoraphobia (the effectiveness of the drug is maintained for 1 year, preventing relapse of panic disorder).
- Treatment (including supportive and preventive therapy) of social phobia in adults, as well as in children and adolescents aged 8-17 years (the effectiveness of the drug is maintained with long-term treatment of this disorder).
- Treatment (including maintenance and preventive therapy) of generalized anxiety disorder (the effectiveness of the drug is maintained during long-term treatment of this disorder, preventing relapse of this disorder).
- Treatment of post-traumatic stress disorder.

Contraindications Paxil

Simultaneous administration of MAO inhibitors and a period of 14 days after their withdrawal (MAO inhibitors cannot be prescribed within 14 days after the end of treatment with paroxetine).
- Simultaneous reception of thioridazine.
- Hypersensitivity to paroxetine and other components of the drug.

Use during pregnancy and lactation Paxil

In experimental studies, no teratogenic or embryotoxic effects of paroxetine have been identified. Data from a small number of women who took paroxetine during pregnancy suggest no increased risk of congenital anomalies in newborns. There are reports of premature birth in women who received paroxetine during pregnancy, but a causal relationship with the drug has not been established. Paxil should not be used during pregnancy unless the potential benefit of treatment outweighs the possible risk associated with taking the drug.
It is necessary to monitor the health of newborns whose mothers took paroxetine in late pregnancy, since there are reports of complications in children (however, a causal relationship with the drug has not been established). Respiratory distress syndrome, cyanosis, apnea, convulsive seizures, temperature instability, feeding difficulties, vomiting, hypoglycemia, arterial hyper- or hypotension, hyperreflexia, tremor, irritability, lethargy, constant crying, drowsiness are described. In some reports, the symptoms have been described as neonatal manifestations of the withdrawal syndrome. In most cases, the described complications occurred immediately after childbirth or shortly after them (within 24 hours). Paroxetine is excreted in small amounts in breast milk. Therefore, the drug should not be used during lactation, unless the potential benefit of treatment outweighs the possible risk associated with taking the drug.

Dosage and administration of Paxil

Inside, in the morning - 20 mg. With insufficient effect, it is possible to increase the dose by 10 mg / day with an interval of at least 1 week (maximum dose - 50 mg / day). In elderly, malnourished patients, as well as in violation of the function of the kidneys and liver, the initial dose is 10 mg / day, the maximum is 40 mg / day.

Paxil side effects

Drowsiness or insomnia, tremor, nervousness, increased excitability of the central nervous system, impaired concentration, emotional lability, amnesia, dizziness, accommodation paresis, pupil dilation, eye pain, noise and pain in the ears, increase or decrease in blood pressure, fainting, tachycardia or bradycardia, violation of cardiac conduction and peripheral circulation, cough, rhinitis, dipnea, tachypnea, nausea, loss of appetite, dyspepsia, increased activity of hepatic transaminases, stomatitis, arthralgia, arthritis, dysuria, polyuria, urinary incontinence, urinary retention, amenorrhea, dysmenorrhea, miscarriage, mastitis , violation of ejaculation, decreased libido and potency, peripheral edema, weight loss or increase, anemia, leukopenia, allergic reactions (itching, urticaria, chills). Rarely - thinking disorders, akinesia, ataxia, convulsions, hallucinations, hyperkinesia, manic or paranoid reactions, delirium, euphoria, grand mal seizures, aggressiveness, nystagmus, stupor, autism, decreased visual acuity, cataracts, conjunctivitis, glaucoma, exophthalmos, angina pectoris, myocardial infarction, cerebrovascular accident, heart rhythm disturbances, eosinophilia, leukocytosis, lymphocytosis, monocytosis, hematuria, nephrourolithiasis, impaired renal function, dermatitis, erythema nodosum, depigmentation.

Special instructions Paxil

It should be taken with caution in renal and hepatic insufficiency, angle-closure glaucoma, prostatic hyperplasia, mania, cardiac pathology, epilepsy, convulsive conditions, in combination with electrical impulse therapy, in patients receiving drugs that increase the risk of bleeding, with risk factors for increased bleeding. During treatment, you must refrain from taking alcoholic beverages. Use with caution during work for drivers of vehicles and people whose profession is associated with increased concentration of attention. With abrupt cancellation - dizziness, sensory disturbances, sleep disturbance, agitation, anxiety, nausea, sweating. Care should be taken when prescribing in combination with lithium preparations. At the time of treatment should refrain from drinking ethanol.

Paxil drug interactions

Inducers of microsomal oxidation (phenobarbital, phenytoin) reduce blood concentration and activity, inhibitors (cimetidine) - increase. Increases the level of procyclidine in plasma. Incompatible with MAO inhibitors. Co-administration with indirect anticoagulants can cause increased bleeding with an unchanged prothrombin time. Enhances the effect of alcohol.

Paxil overdose

Available information on paroxetine overdose suggests a wide range of safety.
Symptoms: increased side effects described above, vomiting, dilated pupils, fever, changes in blood pressure, involuntary muscle contractions, agitation, anxiety, tachycardia.
Patients usually do not develop serious complications even with a single dose of up to 2 g of paroxetine. In some cases, coma and changes in the EEG develop, and very rarely, death occurs with the combined use of paroxetine with psychotropic drugs or alcohol.
Treatment: standard measures used for an overdose of antidepressants (gastric lavage through artificial vomiting, the appointment of 20-30 mg of activated charcoal every 4-6 hours during the first day after an overdose). The specific antidote is unknown. Supportive therapy and control of vital body functions are shown.

Paxil storage conditions

Store in a dry place at a temperature not exceeding 30°.

In an online pharmacy Paxil can be purchased with home delivery. The quality of all products in our online pharmacy, including Paxil, undergo quality control of goods by our trusted suppliers. You can buy Paxil on our website by clicking on the "Buy" button. We will be happy to deliver Paxil to you absolutely free of charge to any address within our delivery area.

Paxil is a potent selective serotonin reuptake inhibitor with potent antidepressant activity.

The drug is available in the form of tablets for oral administration. The active substance of the drug Paxil is paroxetine hydrochloride in the amount of 20 mg.

As auxiliary elements, magnesium stearate, calcium hydrogen phosphate, titanium dioxide are used.

The chemical structure of Paxil and other drugs from the group of tetracyclic and tricyclic antidepressants is different.

Pharmacological effect

The action of the drug Paxil is associated with its ability to promote selective blocking of serotonin reuptake and enhance serotonergic effects in the central nervous system, which has an antidepressant effect. The psychotropic activity of the drug is associated with its ability to:

• eliminate depression;
• relieve the patient of anxiety.

No carcinogenic or mutagenic effects of the drug have been identified.

According to research results, the drug may have a moderate activating effect when used at a dosage higher than that required to inhibit serotonin uptake. Paxil does not contribute to the impact on the cardiovascular system, disorders of psychomotor functions, as well as depression of the central nervous system.

In the treatment of depressive conditions, Paxil demonstrates efficacy that can be compared with the effects of drugs from the group of tricyclic antidepressants. The active component of the drug demonstrates the proper therapeutic effect even during the therapy of those patients who did not respond positively to previous treatment with drugs from the antidepressant group.

An improvement in the patient's well-being is observed after 1 week of using the tablets.

If you use Paxil in the morning, the active ingredient of the drug does not adversely affect the duration of sleep. In addition, effective therapy can improve the quality of sleep.

According to the results of studies, in patients who took the drug Paxil for 12 months, the risk of relapse of depressive conditions is significantly reduced.

If the drug is used in the treatment of panic disorders in combination with drugs that improve behavior and cognitive functions, the administration of Paxil has a more pronounced therapeutic effect than mono-treatment with other groups of drugs.

The absorption of the active substance occurs in the liver area, the achievement of a stable concentration in the blood plasma is observed after 1-2 weeks of regular tablet intake. The excretion of the active component is carried out together with excrement.

The elimination half-life for each patient may vary, on average it takes from 15-16 hours to a day.

Indications for admission

Paxil is indicated for use in the treatment of various types of depressive conditions:

• reactive depression;
• severe depression;
• depression accompanied by anxiety.

In addition, tablets can be used to identify the following conditions:

During the first few weeks of using the tablets, there is a decrease in the symptoms of depressive states, suicidal thoughts disappear.

Mode of application

Paxil tablets should be taken once a day, with meals. The drug should not be chewed. The exact dose and course of treatment are selected, taking into account the indications for admission and the patient's complaints.

In the treatment of depression, the effectiveness of the prescribed treatment should be evaluated (a few weeks after the start of treatment) and, if necessary, the dose of the drug should be adjusted. The duration of stopping and maintenance treatment can take up to several months.

Patients with severe liver and kidney dysfunction should take the tablets at the lowest effective dose.

It is worth refraining from abruptly stopping the use of Paxil tablets. . If during the period of a gradual decrease in the dosage of the patient, the withdrawal syndrome is disturbed, then it is recommended to resume taking the previously used dosage. In the future, the dose should be reduced more slowly.

Paxil is not intended for self-medication, you should always consult your doctor before taking the tablets.

Development of an overdose

With an overdose of Paxil, it is possible to increase unwanted side reactions, as well as the development of fever, blood pressure disorders, tachycardia, anxiety, and involuntary muscle contraction. In most cases, the patient's well-being returns to normal without serious complications.

Rarely, there was information about cases of coma and ECG changes, and sporadically about lethal outcomes. In most cases, such conditions were provoked by the combination of Paxil with alcohol or other psychotropic substances.

Overdose therapy can be carried out in accordance with its manifestations, as well as the instructions of the national poison control center. There is no specific antidote. Therapy includes general measures that are required in case of an overdose of an antidepressant. In addition, the main physiological parameters of the body should be monitored and supportive treatment should be carried out.

Contraindications

Paxil is contraindicated for use:

• with intolerance to the active or auxiliary elements;
• simultaneously with MAO inhibitors, thioridazine and pimozide substances;
• Paxil is also not used in the treatment of persons under the age of 18 years.

Use during pregnancy

Before the appointment of Paxil during the treatment of women who are expecting a child, the possibility of using alternative methods of treatment should be considered. There is information about cases of premature birth of children whose mothers use Paxil in late pregnancy. Tablets should not be taken unless the potential risk outweighs the potential benefit.

A certain amount of the active substance of the drug has the ability to penetrate into breast milk. For this reason, the drug is not prescribed if the potential benefit does not outweigh the likely harm to the child.

Despite the fact that the teratogenic effects of Paxil have not been identified, tablets are used during the treatment of pregnant women only in exceptional cases.

The active ingredient of the drug may affect the quality of sperm.

Adverse reactions

Paxil can cause disorders of the immune, endocrine, cardiovascular, digestive, reproductive, respiratory systems, as well as mental disorders, metabolic disorders.

The most commonly reported were blurred vision, headache, yawning, tremors, dizziness, drowsiness, agitation, sleep disturbances, decreased appetite, nausea, stool disorders, dry mouth, sweating, sexual dysfunction, asthenia, and weight gain.

When Paxil treatment was stopped, the most common complaints were dizziness, sensory disturbances, anxiety, headache, and sleep disturbances.

drug interaction

When Paxil is combined with hypnotic drugs with a short period of action, the development of additional adverse reactions is not observed.

Paxil dosage adjustment may be required when combined with drugs from the group of tricyclic antidepressants, as well as medicines based on metoprolol, procyclidine, flecainide, encaidine, propafenone, thioridazine.

The active substance of the tablets may increase the effect of drugs containing alcohol, as well as reduce the effectiveness of medicines, the active substance of which is tamoxifen and digoxin.

Simultaneous use with drugs from the group of indirect anticoagulants and antithrombotic agents may lead to the risk of bleeding.

Paxil should not be used simultaneously with drugs based on methylene blue and medicines from the group of MAO inhibitors, as well as for 14 days after stopping their use. MAO inhibitor drugs should not be taken for 14 days after completion of therapy with Paxil.

In the course of controlled clinical trials, Paxil did not demonstrate adequate efficacy in the treatment of depressive conditions in patients of younger and adolescence (from 7 to 17 years old). For this reason, the drug is not used in the treatment of this age group of patients.

Since the active substance of the drug can contribute to the development of mydriasis, the drug is used with extreme caution in the treatment of patients with angle-closure glaucoma.

Experience with the use of the drug simultaneously with electroconvulsive therapy is limited.

Paxil is used with extreme caution in the treatment of people with a history of epilepsy.

When prescribing the drug, the risk of bone fracture should be taken into account.

When driving vehicles and performing potentially hazardous types of work, special care must be taken.

The drug is used with extreme caution in the treatment of patients with a history of mania.

The combination of the active substance of the drug with alcoholic beverages is not recommended.

Storage of the drug should be carried out in a place inaccessible to children and sunlight. Tablets are stored in compliance with the temperature regime - no more than 30 degrees.

This medication is available in pharmacies as a prescription drug.

Analogues, cost

The cost of the drug Paxil for the period June 2016 is formed as follows:

1. Tablets 30 pcs., 20 mg - 700-730 rubles.
2. Tablets 100 pcs., 20 mg - 2130-2190 rubles.

Analogues of the drug Paxil are: Reksetin, Plizil N, Paroxetine, Adepress, Actaparoxetine.