Kor testimony. Concor tablets: instructions for use. Negative manifestations of the use of "Concor Cor"

It will be useful for people taking adrenergic blockers to know how Concor differs from Concor Cor. Means can be considered analogues, since they are based on one active substance called.

It is used to treat hypertension, angina pectoris, and congestive heart failure. However, it would be more accurate to call these medicines different pharmaceutical forms of the same product.

The drug is now available in three forms - 2.5 mg, 5 mg and 10 mg. Each of them has its own testimony. To understand the difference between Concor and Concor Cor, and not to get confused when buying a medicine at a pharmacy, you need to study the instructions for use in detail. Remember that you can not prescribe the drug yourself! Only a specialist can choose a safe dose that matches the diagnosis.

What is the difference between Concor and Concor Core?

People with heart pathologies who are prescribed bisoprolol often wonder how Concor differs from Concor Cor, and whether it is possible to replace one drug with another.

The similarity in the name gives rise to misconceptions. Both drugs are based on the same blocker: bisoprolol fumarate. The difference lies in the dose. the composition contains the smallest amount of active ingredient among other forms - 2.5 mg, in - 5 or 10 mg of bisoprolol.

Concor differs from Concor Cor in the appearance of tablets. They are stylized in the form of a heart: Concor-10 is yellow-orange, and the rest of the forms are in a white shell. You can distinguish drugs by the design of the packaging. The colors on the form boxes are different, the dosage is always indicated on the front side.

Concor Cor differs from Concor in the release form:

  • 2.5 mg agent is produced in packs of 10, 5 or 3 blisters of 10 tablets;
  • preparations of 5 and 10 mg can be found in packages of 30, 50 and 90 tablets.

The components of both medicines are identical. The composition of the tablets contains a certain dose of bisoprolol and the necessary excipients.

Tablets differ in cost: a high-dose drug has a higher price tag than similar drugs with a low dose of bisoprolol.

What is the difference in indications?

The difference between Concor and Concor Cor is as follows: a large dosage of the first remedy allows you to treat:

  • hypertension ();
  • angina pectoris (angina pectoris);

Bisoprolol in large quantities effectively relieves the symptoms of cardiac pathologies without harm to health. The dose of the substance in these cases is calculated individually. In the treatment of heart failure, doctors prescribe a low-dose form, since the initial dose of bisoprolol for the treatment of this disease is 1.25 mg. Later, the patient can, on the recommendation of a cardiologist, switch to 5 or 10 mg tablets.

Large doses of bisoprolol are dangerous in heart failure, therefore, in CHF, a low-dose drug is prescribed for use. To eliminate the symptoms of hypertension and ischemia, the drug is prescribed in combination with other cardiac drugs.

Both drugs are contraindicated in the presence of heart failure in the phase of decompensation. In addition, drugs are not allowed for persons under 18 years of age and are used with great care during pregnancy.

During pregnancy, treatment with bisoprolol is allowed only if it is necessary to maintain the health of the mother. have the ability to reduce blood flow in the placenta - and this can have a serious impact on the formation of the fetus and provoke developmental defects. When taking funds of this type during pregnancy or breastfeeding, careful monitoring of the condition of the child and a willingness to take action in case of a threat to life are required.

Effects of beta-blockers on the cardiovascular system

Difference in dosage and application

The difference between Concor cor and Concor is also in the dosage of the drug.

  1. In the treatment of hypertension and stable angina pectoris, the standard initial dosage is 5 mg daily. If the effect of taking the drug is insufficient, the daily amount of the active substance is increased to 10 mg. It must be remembered that taking more than 20 mg per day is prohibited.
  2. Concor Cor differs from Concor in that it is more convenient to take in the treatment of CHF. The initial dosage for this disease is 1.25 mg per day, and a low-dose tablet will be easily divided into two parts.

Before the course of treatment for CHF, the patient goes through the stage of dose selection. Exacerbations in the last 6 months should not be observed.

Increasing the dosage in CHF is carried out no more than 1 time in two weeks. If the patient normally perceives the dose, it is allowed to increase it to 10 mg per day. With a maximum dose increase, the patient can switch to high-dose tablets. This dosage regimen is recommended, with individual selection, the doctor may prescribe the primary dose both in a larger amount and in a smaller one.

Adrenoblockers inhibit cardiac activity, therefore, during the course, specialist supervision is necessary to assess the patient's condition. The doctor monitors changes in blood pressure, pulse, and the severity of CHF symptoms. During treatment, there may be a worsening of the course of the disease, a decrease in the level of pressure or bradycardia. Then it is possible to reduce the dosage or cancel the intake.

Concor does not differ from Concor core in terms of time and method of administration. Bisoprolol is valid for 24 hours, so the tablets are drunk once in the morning. It does not matter how the patient takes the medicine, on an empty stomach or after breakfast, the main thing is to take it at the same time. This applies to both drugs. Dose adjustment can only be carried out by a doctor, the patient should in no case independently increase or decrease the dose and switch to other drugs. The duration of treatment is also determined by the specialist.

Which is better of the two drugs?

Patients suffering from pathologies of the heart and blood vessels often ask - which is better, Concor or Concor Cor? It's impossible to say which is better. Concor differs from Concor Cor in the amount of active active substance, therefore the funds are prescribed on an individual basis. The dose is determined by the doctor and depends on the diagnosis of the patient.

For the treatment of CHF, 2.5 mg tablets are prescribed. A low dosage of bisoprolol is optimal for the treatment of this problem. For drug treatment of problems such as hypertension, the use of a high-dose agent is optimal.

Both drugs work in the same way:

  • lower the pressure level;
  • reduce the heart rate;
  • stabilize the rhythm of the heartbeat;
  • reduce the risk of a heart attack.

Concor differs from Concor Cor in that the former has a lower dosage of bisoprolol and therefore its effect is less pronounced. A low-dose agent is more often prescribed for the treatment of CHF, so as not to harm the patient. When buying a medicine at a pharmacy, you must carefully examine the packaging so as not to confuse the medicines and not accidentally increase the dose.

With a gradual increase in dosage during the treatment of CHF, you can gradually switch to the drug 5 or 10 mg. In this case, the daily intake of the medicine will be more convenient, and the patient will need to drink only one tablet per day.

A 2.5 mg agent can be taken when a dose of 7.5 mg of bisoprolol per day is prescribed by a specialist. Instead of breaking pills in half, it's more convenient to take three low-dose pills. During the period of withdrawal, the doctor may also prescribe a drug with a low dose of the active substance.

In the event that a low-dose form is mistakenly acquired in the treatment of ischemia, hypertension or angina pectoris, the remedy simply will not have the desired effect. A sharp decrease in the dose can also lead to a deterioration in the work of the heart.

Do not prescribe the drug yourself, it can be fraught with dangerous consequences. In the event that the dose seems to the patient to be too high, from which he feels worse, or vice versa - too low, you should consult your doctor.

Useful video

From the following video, you can learn useful information about a person's blood pressure:

Conclusion

  1. A detailed analysis of the instructions for taking medications based on bisoprolol allows you to understand how Concor Cor and Concor differ. The main difference is in the dosage of the active substance. The prefix Cor indicates that the tablet contains a small amount of bisoprolol, only 2.5 mg.
  2. The drug effectively copes with the symptoms of CHF, however, it can be used in complex therapy in the treatment of other cardiac pathologies in combination with other drugs.
  3. Concor differs from Concor cor in that it is more effective in diseases such as hypertension, angina pectoris, ischemia.
  4. A high amount of bisoprolol - 5 and 10 mg - allows you to solve problems such as high blood pressure, unstable heart rate, insufficient blood supply to heart tissues.
  5. Each of the medicines is effective in the case of a specific diagnosis. Therefore, it is important to carefully examine the packaging before buying, so as not to make a mistake with the dosage.

Concor Cor 2.5 mg is an original β 1 -adrenergic blocker intended for the treatment of the chronic type. Its action is aimed at a rapid decrease in the activity of renin in the blood plasma, a reduction in the amount of oxygen necessary for the normal functioning of the myocardium and a decrease in heart rate. The instructions for Concor should be carefully studied by the patient before use, since there are many contraindications in it.

Description

Concor Cor is produced only in the form of tablets. The active ingredient in it is bisoprolol. It has antianginal, antiarrhythmic and hypotensive effects. Prescribe the drug mainly to older people. A single dose of this drug reduces the heart rate and myocardial oxygen demand. The patient has a reduced risk of death due to heart disease.

Important! Concor Cor is excreted through the kidneys. The withdrawal period is more than 12 hours.

You can buy Concor Cor in a pharmacy only with a prescription from a doctor. The price of the drug varies between 170-200 rubles. The country of origin is Germany.

How to take Concor Cor?

Concor Cor tablets should be taken on an empty stomach in the morning with plenty of water. In chronic cases, the cardiologist titrates the dose of the drug and constantly monitors the patient's condition. The dosage in this case can be increased when the previous one was safely tolerated by the patient.

Note! The maximum dose of the drug in chronic heart failure should not exceed 10 mg.

At the beginning of taking the medication, the patient should be under the supervision of a doctor for the first 4 hours, who controls the pulse and conduction indicators. If the maximum recommended dosage is not well tolerated, then the cardiologist gradually reduces it. It is strictly forbidden to abruptly stop treatment or change dosages without the knowledge of the doctor, as this is fraught with a deterioration in well-being.

Contraindications

Concor Cor has a number of contraindications:

  • individual intolerance to the components;
  • arterial hypotension;
  • Short syndrome;
  • bradycardia;
  • sinoauricular blockade;
  • bronchial;
  • cardiogenic shock;
  • pheochromocytoma;
  • metabolic acidosis;
  • age under 18 years old.

Important! You can not combine taking Concor Cora with alcohol, since the drug enhances the negative effect of ethyl alcohol.

The drug during pregnancy is approved for use only if the benefit of treatment for the mother significantly outweighs the potential risk of side effects in the fetus.


Side effects

In rare cases, Concor Cor may cause the following side effects:

  • impotence;
  • fast fatiguability;
  • dizziness;
  • sleep disturbance;
  • depression;
  • hallucinations;
  • hearing impairment;
  • decrease in arterial;
  • bronchospasm;
  • allergic;
  • convulsions;
  • dyspeptic disorders;
  • decreased libido in men;
  • skin rashes;

Analogues

You can replace Concor Cor with such analogues:

  • Biol;
  • Dorez;
  • Bidop Kor;
  • Niperten;
  • Coronal;
  • Bisomore;
  • Tirez;
  • Nebilong;
  • Bisogamma and others.

Biol

It is a β 1 ​​-blocker that has antianginal, antiarrhythmic and hypotensive effects. Release the drug in the form of tablets. The active ingredient in it is bisoprolol.

Biol is prescribed for people with arterial hypertension, with coronary artery disease to prevent attacks and in chronic heart failure in combination with other medicines.

Note! Biol is contraindicated in case of individual intolerance to components, cardiogenic shock, Raynaud's syndrome, severe forms of bronchial asthma, metabolic acidosis and children under 18 years of age.

The price of Biol is 120 - 450 rubles, depending on the dosage of the active substance. Country of origin - Switzerland.


Dorez

The drug is based on bisoprolol. It has proven itself in the fight against the symptoms of arterial hypertension and chronic heart failure with reduced heart contractility.

Important! Dorez is not recommended for use in symptomatic bradycardia, severe bronchial, pheochromocytoma and individual hypersensitivity.

The price of the drug Dorez ranges from 300-350 rubles. Country of origin - Macedonia.

Coronal

Coronal is a selective β-blocker that has antihypertensive and antiarrhythmic effects. It helps to reduce heart rate and myocardial contractility. The active substance in the preparation is bisoprolol fumarate. It reduces the heart's need for oxygen and increases endurance during physical exertion.

The hypotensive effect of the drug is due to the ability to reduce the minute volume of blood and restore the normal sensitivity of baroreceptors located on the aortic arch. A positive result in the treatment of arterial hypertension is observed 2-5 days after the start of taking Coronal. The course of treatment is usually 1-2 months.

Coronal is intended for the treatment of myocardial damage and myocardial prevention. Like Concor Cor, Coronal can only be purchased with a prescription. Also, drugs have similar contraindications and side effects.

The price of Coronal is 150-535 rubles. Country of origin - Czech Republic.


Nebilong

It is a cardioselective β-blocker of the III generation. The active ingredient in it is nevibolol.

Nebilong is prescribed for essential arterial hypertension and chronic heart failure in people over 70 years of age. The drug reduces the heart rate and blood pressure during exercise and at rest. In addition, it improves diastolic function of the heart and has an antianginal effect.

Note! Nebilong is contraindicated in people with severe hepatic impairment and cardiogenic shock. Also, it is not used to treat patients with muscle weakness, myasthenia gravis and depression.

The price of Nebilong is 420-660 rubles. The country of origin is India.


Bisogamma

A drug based on bisoprolol, which has ananginal, hypotensive and antiarrhythmic effects. Bisogamma is used to treat arterial hypertension and prevent angina attacks.

Important! The drug is contraindicated in pulmonary edema, sinoatrial blockade, Raynaud's disease, depression and metabolic acidosis. Caution should be taken by Bisogamma to people with liver failure and.

The price of the drug is 140-200 rubles. The country of origin is Germany.

Merck KGaA Merck KGaA for Nycomed

Country of origin

Austria Germany

Product group

Cardiovascular drugs

Beta1 blocker

Release form

  • 10 - blisters (3) - packs of cardboard.

Description of the dosage form

  • Film-coated tablets

pharmachologic effect

hypotensive, antianginal, antiarrhythmic. Pharmacokinetics Selective beta1-blocker, without its own sympathomimetic activity, does not have a membrane-stabilizing effect. Reduces the activity of blood plasma renin, reduces myocardial oxygen demand, reduces heart rate (at rest and during exercise). It has antihypertensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenergic receptors of the heart in low doses, it reduces the formation of cAMP from ATP stimulated by catecholamines, reduces the intracellular current of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect (inhibits conduction and excitability, slows down AV conduction). With an increase in the dose above the therapeutic one, it has a beta2-adrenergic blocking effect. OPSS at the beginning of the use of the drug, in the first 24 hours, slightly increases (as a result of a reciprocal increase in the activity of alpha-adrenergic receptors), which after 1-3 days returns to the original, and decreases with long-term administration. The hypotensive effect is associated with a decrease in the minute volume of blood, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin system (it is of great importance for patients with initial renin hypersecretion), restoration of sensitivity in response to a decrease in blood pressure and an effect on the central nervous system. With arterial hypertension, the effect occurs after 2-5 days, stable action - after 1-2 months. The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate, a slight decrease in contractility, a prolongation of diastole, and an improvement in myocardial perfusion. The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP content, arterial hypertension), a decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers and a slowdown in AV conduction (mainly in the anterograde and, to a lesser extent, in the retrograde directions through AV node) and along additional paths. When used in medium therapeutic doses, unlike non-selective beta-blockers, it has a less pronounced effect on organs containing beta2-adrenergic receptors (pancreas, skeletal muscles, smooth muscles of peripheral arteries, bronchi and uterus) and on carbohydrate metabolism, does not cause delay sodium ions (Na+) in the body; the severity of the atherogenic action does not differ from the action of propranolol.

Pharmacokinetics

Suction. Bisoprolol is almost completely (> 90%) absorbed from the gastrointestinal tract. Its bioavailability due to insignificant metabolization during the "first pass" through the liver (at the level of approximately 10-15%) is about 85-90% after oral administration. Eating does not affect bioavailability. Bisoprolol exhibits linear kinetics, with plasma concentrations being proportional to the administered dose over the dose range of 5 to 20 mg. Cmax in plasma is reached after 2-3 hours. Distribution. Bisoprolol is distributed quite widely. The volume of distribution is 3.5 l / kg. Plasma protein binding reaches approximately 35%; capture by blood cells is not observed. Metabolism. Metabolized by the oxidative pathway without subsequent conjugation. All metabolites are highly polar and are excreted by the kidneys. The main metabolites found in blood plasma and urine do not show pharmacological activity. Data obtained from experiments with human liver microsomes in vitro show that bisoprolol is metabolized primarily by CYP3A4 (about 95%), and CYP2D6 plays only a small role. Withdrawal. The clearance of bisoprolol is determined by the balance between its excretion through the kidneys in the form of an unchanged substance (about 50%) and oxidation in the liver (about 50%) to metabolites, which are then also excreted by the kidneys. Total Cl - (15.6 ± 3.2) l / h, and renal Cl - (9.6 ± 1.6) l / h. T1 / 2 - 10-12 hours

Special conditions

It is not recommended to interrupt treatment abruptly and change the recommended dosage without first consulting a doctor, because. this can lead to a temporary deterioration in the activity of the heart. Treatment should not be interrupted suddenly, especially in patients with CAD. If discontinuation of treatment is necessary, the dosage should be reduced gradually. Monitoring the condition of patients taking Concor® Cor should include measuring heart rate and blood pressure (at the beginning of treatment - daily, then 1 time in 3–4 months), ECG, blood glucose determination in patients with diabetes mellitus (1 time in 4–5 months). In elderly patients, it is recommended to monitor kidney function (1 time in 4-5 months). The patient should be taught how to calculate heart rate and instruct about the need for medical consultation with heart rate

Compound

  • bisoprolol hemifumarate (bisoprolol fumarate (2:1)) 2.5 mg Excipients: calcium hydrogen phosphate (anhydrous), corn starch, colloidal silicon dioxide, microcrystalline cellulose, crospovidone, magnesium stearate. Shell composition: hypromellose 2910/15, macrogol 400, dimethicone 100, titanium oxide (E171).

Concor Cor indications for use

  • chronic heart failure

Concor Cor contraindications

  • - acute heart failure; - chronic heart failure in the stage of decompensation; - shock caused by impaired cardiac function (cardiogenic shock); - collapse; - AV block II and III degree, without a pacemaker; - SSSU; - sinoatrial blockade; - Severe bradycardia

Concor Cor dosage

  • 2.5 mg 2.5 mg

Concor Cor side effects

  • The frequency of adverse reactions listed below was determined by the following gradations: very often (? 10%); often (>1%, 0.1%, 0.01%,

drug interaction

The effectiveness and tolerability of drugs may be affected by the simultaneous use of other drugs. Such an interaction can also occur in cases where 2 drugs are taken after a short period of time. The doctor must be informed that you are taking other drugs, even if you are taking them without a prescription. Allergens used for immunotherapy or allergen extracts for skin tests increase the risk of severe systemic allergic reactions or anaphylaxis in patients receiving bisoprolol. Iodine-containing radiopaque diagnostic agents for intravenous administration increase the risk of developing anaphylactic reactions. Phenytoin when administered intravenously, drugs for inhalation general anesthesia (hydrocarbon derivatives) increase the severity of the cardiodepressive effect and the likelihood of lowering blood pressure. The effectiveness of insulin and oral hypoglycemic drugs may change during treatment with bisoprolol (masks the symptoms of developing hypoglycemia: tachycardia, increased blood pressure)

Overdose

arrhythmia, ventricular extrasystole, severe bradycardia, AV blockade, marked decrease in blood pressure, acute heart failure, hypoglycemia, acrocyanosis, shortness of breath, bronchospasm, dizziness, fainting, convulsions

Storage conditions

  • keep away from children
Information provided by the State Register of Medicines.

Synonyms

  • Bisogamma, Bisocard, Bisopronkor, Concor Cor, Coronal

Concor Cor, the instructions for use of which states that this is one of the best drugs that is used in the fight against cardiovascular diseases, is famous for its low price and fast action, and helps to reduce blood pressure in a timely manner. The active substance of the drug is a group of beta-blockers that can quickly block beta-adrenergic receptors in the heart. Patients with disorders in the work of the cardiovascular system often prefer the drug Concor Cor.

Instructions for use describe the pharmacokinetics of the drug. According to the instructions, the drug is able to have both antianginal and antiarrhythmic effects. If the drug is taken by a patient suffering from hypertension, the result is noticeable after 4-5 days, a permanent improvement in the condition occurs after 30-60 days.

The main advantage of the mechanism of action of the drug Concor Cor, instructions for use for which comes with the tablets, is its ability to suppress the transmission of a nerve impulse, which is located in adrenoreceptors.

Biosporol, which is one of the main components of the substances contained in the preparation, is able to quickly reduce the minute volume of blood.

With regular use of the drug, significant improvements occur after the first two months of use., and the visible result is noticeable after the first five days of application. Blood pressure decreases steadily, Concor Cor does not cause discomfort in other internal organs.

The second significant advantage of the drug is a decrease in myocardial oxygen demand, due to which a contraction occurs. The period of diastole gradually increases. This effect in medicine is called antianginal.

The electrical conductivity of the myocardium slows down, the electrical impulses, the processes of formation of which occur in the sinus node and the incomplete blocking of the sympathetic division of the nervous system, are factors in the formation of antiarrhythmic effects.

Concor Cor - what helps, release forms

Concor Cor - what the drug helps with and what it is produced in, we'll talk further. Concor Cor is available only in tablets. It is also worth noting the original design - the tablets are shaped like a heart. They are covered with a white shell and on both sides there is a risk with which it is easy to break the tablet into two parts.

The number of pieces in one package can be from 10 to 30, respectively, and the price will vary. According to these data, the cost of the minimum package of the drug is no more than 170 rubles. The tablets are packed in special foil blisters.

Unfortunately, due to the existing contraindications, it is impossible to purchase Concor Cor without a doctor's prescription.

What does the drug help? Patients suffering from various cardiac diseases, including arrhythmia, angina pectoris, arterial hypertension, acute or mild heart failure and other heart diseases, are prescribed Concor. Instructions for use, at what pressure to take and other information should be explained to you in detail by your doctor.

The drug should be taken strictly under the supervision of a doctor, the drug Concor should be taken, the dosage should be carefully observed. Otherwise, self-medication will lead to life-threatening consequences.

The maximum daily dose used should not exceed 10 mg. If the manifestations of heart failure become more frequent, you should urgently reduce the dose and consult a doctor for its subsequent adjustment.

The medication is taken for a long time (from two weeks to several months). Abrupt withdrawal of use can lead to serious problems, so the withdrawal of the drug occurs by gradually reducing the dosage.

note

The list of contraindications to the drug is quite large, which once again emphasizes the need to control its intake with the attending physician. Before starting treatment, tests are required, thanks to which you can assess the general degree of the patient's condition and find out about intolerance to any components of the drug.

Contraindications:

  • Individual intolerance to the components of the drug.
  • Prinzmetal's angina.
  • The drug must not be used by minors under the age of 18.
  • With bronchial asthma and any diseases of the upper and lower respiratory tract, it is extremely forbidden to use the drug.
  • metabolic acidosis.
  • Pheochromocytoma.
  • Bradycardia in any form of manifestation.
  • Shock conditions of any severity.
  • Severe AV block.
  • Cardiac unworthiness in a decompensated form.
  • Some forms of heart failure.
  • Collapse.

Tablets Concor Cor - instructions for use and comparison of drugs Concor and Concor Cor

Concor Cor tablets, instructions for use of which are always in the pharmacy, must be taken orally without chewing. Drink plenty of water.

It is taken once a day, in the morning. Food intake does not depend on application.

The attending physician will prescribe the dosage for each patient individually. In this case, the general condition of the patient and the clinical indications will be taken into account.

For the treatment of angina pectoris or arterial hypertension, the dosage is selected taking into account the indications of the heart rate. The course should start from 4 mg per day. If the need arises, the dosage can be increased to 9 mg, it is better not to exceed more than 15 mg.

It is better then to replace them with Concor tablets, the instructions of which contain all the information about the daily dosage.

However, if necessary, the doctor may prescribe Concor Cor tablets. Instructions for use do not recommend taking this drug by pregnant women, because they have not yet fully studied how it affects the development of the fetus. In addition, there is a decrease in blood flow saturation. All this leads to a lack of blood supply to the placenta. Therefore, the drug is prescribed only, as a last resort, an increase in blood pressure. In addition, a woman must be under the close attention of medical personnel who will assess the general condition and development of the fetus.

Approximately two days before the scheduled date of delivery, the use of the drug should be stopped. The dosage and course of treatment is determined by the doctor who observes the woman during pregnancy.

During breastfeeding, you should stop taking the drug. If there is a need to take the drug during lactation, breastfeeding should be stopped for a while.

Consider how Concor Cor tablets and Concor tablets differ, their instructions are almost the same, but there is still a difference. These two drugs in their composition have the active substance Bisoprolol. They are complete analogs. They differ only in the dosage of the active substance. Release "Concor" in tablets that contain 5 or 10 mg of the active substance, and "Concor Cor" has only 2.5 mg of the substance. They also have external differences. "Concor Cor" is produced in white, and "Concor" is painted in yellow.

Concor - side effects and interactions with other drugs

Concor, the side effects of which occur infrequently, can be manifested by the following symptoms: weak heartbeat, slight drops in blood pressure, nausea, and worsening of the general condition:

  • In the circulatory system, side effects are: bradycardia (decrease in heart rate), numbness of the extremities, hypotension.
  • In the nervous system: dizziness, depression, insomnia, bad dreams, hallucinations.
  • Respiratory system: exacerbation of bronchial asthma.
  • In the musculoskeletal system: convulsions, muscle weakness.
  • Sense organs: hearing impairment, purulent eye diseases.
  • Digestion: nausea, vomiting, diarrhea, increased levels of AST and ALT in the bloodstream, diarrhea.
  • Genitourinary system: violation or lack of potency in men.
  • Skin: alopecia, allergy (appearance of itching, rash, redness of the skin).

In case of an overdose of Concor, side effects may manifest as the following symptoms:

  • Decrease in heart rate.
  • Severe drop in blood pressure.
  • Bronchospasms.
  • The development of hypoglycemia (decrease in the content of glucose in the bloodstream).
  • AHF (acute heart failure).

If you experience any of the above side effects, then you should immediately stop the use of this drug, and treat according to symptoms.

If bradycardia develops, then appoint / in Atropine. With hypotension, intravenous vasopressor drugs and plasma-substituting solutions are prescribed. Exacerbation of CHF is stopped by the introduction of diuretics and vasodilators. Hypoglycemia is treated with glucose solution, and bronchospasm is treated with aminophylline.

The patient should tell the doctor if he is currently taking other drugs.

  • Antiarrhythmic drugs, since the active substance "" can lower the conductivity and contractility of the heart.
  • Antihypertensive drugs. Their simultaneous use can cause bradycardia and a decrease in cardiac output.
  • cardiac glycosides. This is dangerous because the pulse time may increase and the heart rate may decrease.

Despite the effective effect on the body, many patients are looking for analogues of this drug. An analogue is a drug that has the same pharmacological group, but differs in composition (a different active substance).

Here is some list of analogues of "Concora Cor":

  1. "Bikard"
  2. "Bisocard"
  3. "Bisoprolol-lugal"
  4. "Cardiosafe"
  5. "Coronal"
  6. "Corvitol"

Currently, there is an analogue in Russia - "Biprol". Most often, the cost of an analogue is always several times lower. For example, the cost of the drug Biprol is 150 rubles and it is much cheaper compared to the drug Concor 2.5 mg, the instructions for use of which will always help determine the dosage.

The cost of the drug varies from 310 to 360 rubles per package (5 mg No. 50). A package of 50 tablets (10 mg) will come out from 460 to 580 rubles on average.

Subject to all the rules for the use and prescription of the dosage, it is effective for the treatment of arrhythmias, hypertension, and chronic heart failure.

In a quantitative ratio of 2:1.
Excipients: colloidal silicon dioxide , corn starch, MCC, crospovidone, magnesium stearate, calcium hydrogen phosphate.
Shell composition: macrogol 400, hypromellose 100, titanium oxide.

Release form

Concor Cor - white-coated tablets, biconvex, heart-shaped, serifed at both ends.

Existing release forms: 10 tablets in a blister, 3 blisters in a paper pack; 14 or 30 tablets in a blister, 1 blister in a paper pack; 25 tablets in a blister, 1 blister in a paper box.

pharmachologic effect

Renders hypotensive, antiarrhythmic, antianginal action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

bisoprolol - electoral beta blocker , which does not have sympathomimetic activity and membrane-stabilizing action.

Lowers: the content of renin in the blood, the need of the heart for oxygen, the number of heartbeats. Blocks in small doses β1-adrenergic receptors , reduces the activation catecholamines synthesis cAMP from ATP , lowers intracellular transit of calcium ions, inhibits conduction and excitability, inhibits AV conduction. With increasing doses, it has a β2-adrenoceptor blocking effect.

The total peripheral resistance in the first day increases slightly, and after another 1-3 days it returns to its original value, and decreases with long-term administration.

The pressure drop is caused sympathetic action on peripheral vessels, a decrease in minute blood volume, inhibition of the renin-angiotensin system. At arterial hypertension The effect appears after 2-5 days.

Antianginal the action is caused by a decrease in the heart's need for oxygen as a result of a decrease in the number of heart contractions per unit of time and contractility, lengthening diastole .

Antiarrhythmic the action is associated with the elimination, increased activity sympathetic system , high content cAMP , braking AV conduction .

Pharmacokinetics

Bioavailability - 85-90%; eating does not affect it. bisoprolol adsorbed from the intestine by 90%. The maximum content in the blood occurs after 3 hours. Binding to blood proteins - up to 35%.

It undergoes transformations along the oxidative pathway. The main derivatives are pharmacologically inactive. Excreted by the kidneys.

Indications for use Concor Cor

Indications for the use of the drug are quite limited. Older people often suffer heart failure according to the chronic type, from which Concor Cor tablets are prescribed in the treatment of this pathology.

Contraindications

  • to bisoprolol or other ingredients of the drug.
  • AV block .
  • Acute and chronic (decompensation) heart failure .
  • Hypotension arterial .
  • Sick sinus syndrome .
  • Bradycardia .
  • Sinoatrial blockade .
  • or COPD .
  • Cardiogenic shock .
  • Violations of the arterial link of the peripheral circulation.
  • Pheochromocytoma .
  • Age up to 18 years.
  • metabolic acidosis .

Side effects

    • General violations: asthenia , fatigue.
    • From the nervous system: syncope , .
    • Mental disorders:, hallucinations,.
    • From the senses of vision: hearing impairment.
    • On the part of the circulatory system: pressure decrease, violation AV conduction, decreased heart rate, orthostatic hypotension .
    • From the respiratory system: bronchospasm , .
    • From the side of the muscular apparatus: convulsions .
    • From the digestive system: vomit , nausea , hepatitis .
    • From the reproductive system: deterioration potency .
    • From the skin: itching, rash, redness,.
    • Lab Indicators: Content Increases triglycerides, AST and ALT

Instructions for use Concor Cor (Method and dosage)

Therapy of a chronic type of heart failure with Concor Cor requires titration and constant medical supervision. When titrating, the dose can be increased only when the previous dose is well tolerated.

The maximum dose in the treatment of chronic heart failure is bisoprolol in the amount of 10 mg once a day.

At the beginning of treatment, when taking half a tablet of Concor Cor, the patient must be observed for the first 4 hours, monitoring the pulse, pressure, and conduction parameters.

Overdose

Symptoms: bronchospasm, AV block, bradycardia, hypoglycemia, excessive pressure drop acute heart failure.
Overdose therapy: discontinuation of the drug and symptomatic therapy.

Interaction

Phenytoin , means for inhalation anesthesia increase cardiodepressive and hypotensive action bisoprolol .

Non-steroidal anti-inflammatory drugs , glucocorticosteroids and estrogens suppress hypotensive effect of the drug Concor Cor.

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