Why drip glucose with ascorbic acid. Ascorbic acid with glucose. Reviews of Ascorbic Acid with Glucose

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

Ascorbic acid with glucose: instructions for use

Compound

Description

Indications for use

Contraindications

Carefully

Diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase; for use in large doses ah - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolithiasis.

Dosage and administration

inside. In terms of ascorbic acid:

Adults with a preventive purpose - 50-100 mg / day, children 6-14 years old, 50 mg of ascorbic acid per day, children over 14 years old, 50-75 mg of ascorbic acid per day;

Adults with a therapeutic purpose - 50-100 mg 3-5 times a day, children from 6 years old - 50-100 mg 2-3 times a day. The duration of therapy and dose is determined by the attending physician.

Side effect

Change laboratory indicators: thrombocytosis, hyperprombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose

Symptoms: when using more than 1 g - headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract, inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day). Decreased capillary permeability (possible deterioration of tissue trophism, increased blood pressure (BP), hypercoagulability, development of microangiopathies).

Interaction with other drugs

Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including that which is part of the oral contraceptives).

Improves intestinal absorption of iron preparations, may increase iron excretion when used concomitantly with deferoxamine.

Reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce absorption and assimilation.

Increases the risk of crystalluria in the treatment of salicylates and sulfonamides short action, slows down the excretion of acids by the kidneys, increases the excretion medicines having an alkaline reaction (including alkaloids, reduces the concentration of oral contraceptives in the blood).

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

In high doses, it increases the excretion of mexiletin by the kidneys.

Barbiturates increase the excretion of ascorbic acid in the urine.

Reduces therapeutic effect antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Application features

At long-term use ascorbic acid, it is necessary to monitor kidney function and blood pressure, regularly monitor the function of the insular apparatus of the pancreas. Patients with high content iron in the body, ascorbic acid should be used in minimum doses.

Appointment of ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the course of the process.

Ascorbic acid as a reducing agent can distort laboratory test results.

Use during pregnancy and lactation

During pregnancy and lactation, it is used only if the intended benefit to the mother outweighs the risk to the fetus and child. During pregnancy and lactation, ascorbic acid is taken only as directed by a doctor. daily requirement for ascorbic acid II-III trimesters pregnancy 90-100 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which is taken by a pregnant woman, and then the newborn may develop a "withdrawal" syndrome. Theoretically, there is a danger to the child when a nursing mother uses high doses of ascorbic acid (it is recommended not to exceed the daily need for ascorbic acid by a nursing mother). The recommended daily requirement for ascorbic acid during lactation is 120 mg.

Influence on the ability to drive vehicles and potentially dangerous mechanisms

Ascorbic acid with glucose contains in one tablet:

the main ingredients are one hundred milligrams of ascorbic acid, 877 mg of glucose;

auxiliary components: talc, potato starch and stearic acid.

Produced in the form of flat-cylindrical tablets of white color, with a chamfer and risk. They are packaged in ten pieces in a blister pack. IN cardboard box there are two blisters. There is also placed instructions for the use of the drug. Also in the box there may be one blister-free package containing ten tablets of ascorbic acid with glucose.

pharmachologic effect

Ascorbic acid with glucose is a vitamin preparation that has a metabolic effect, is involved in the regulation of redox processes, and has a positive effect on carbohydrate metabolism, affects blood clotting, tissue regeneration. Participates in synthesis steroid hormones. The drug significantly increases the body's resistance to various infections, significantly reduces the permeability of capillaries, and also reduces the body's need for vitamins of group "B", E, A, pantothenic and folic acid.

Ascorbic acid is best absorbed in the duodenum and jejunum. Thirty minutes after taking the drug, the content of ascorbic acid in the blood increases significantly. Then it is intensively captured by the cells of the tissues of the body. Initially, ascorbic acid is converted to dehydroascorbic acid, which is able to penetrate through cell membranes without tangible energy costs and quickly recover in the cell. In the cells of various tissues, ascorbic acid is determined in three various forms- ascorbigen ( bound form), ascorbic and dehydroascorbic acids. Ascorbic acid, introduced into the body together with glucose, is distributed very unevenly between organs: large quantity the drug is found in the adrenal glands and other glands internal secretion, much less in the brain, liver, kidneys, skeletal and cardiac muscles. Ninety percent of ascorbic acid is partly metabolized in the kidneys and excreted in the urine in the form of oxalates, and partly in the free form.

Glucose, which enters the human body with ascorbic acid, is easily absorbed. Its metabolism is carried out in two main ways: glycolysis and aerobic oxidation, resulting in the formation of carbon dioxide and water, as well as adenosine triphosphoric acid and other macroergic compounds are released.

Indications

Ascorbic acid with glucose is used in such patient conditions:

hypovitaminosis and avitaminosis C;

pregnancy;

increased need for ascorbic acid;

during the period of intensive growth;

during lactation; during the period of convalescence;

Contraindications

Absolute contraindications for taking ascorbic acid with glucose are hypersensitivity to the ingredients of the drug, thrombophlebitis and a tendency to thrombosis. The drug is also not prescribed to children under six years of age. With caution, ascorbic acid with glucose should be taken in diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase.

In large doses, the drug should not be taken by patients suffering from hemochromatosis, sideroblastic anemia, thalassemia, as well as hyperoxaluria and nephrourolithiasis.

Side effect

The drug can have such side effects:

local and general allergic reactions;

severe irritation of the mucous membrane of organs digestive system, which is manifested by nausea, vomiting, diarrhea, spasm of the gastrointestinal tract;

inhibition of insulin synthesis by the islets of Langerhanz of the pancreas, resulting in hyperglycemia and glucosuria;

when using the drug in high doses for a long time, hyperoxaluria or oxalate nephrocalcinosis develops.

In some cases, laboratory parameters change: thrombocytosis, hypokalemia, erythropenia, hyperprombinemia and neutrophilic leukocytosis may occur.

Overdose

When using more than one gram of ascorbic acid with glucose per day, patients complain of a headache, they have increased excitability of the central nervous system and insomnia develops. Also, people also complain of nausea, vomiting. They develop diarrhea, gastritis with increased acid-forming function, as well as ulceration of the mucous membrane of the stomach and intestines. The function of the insular apparatus of the pancreas may be inhibited, hyperglycemia and glucosuria occur.

When taking large doses of ascorbic acid in the urine, hyperoxaluria (high content of oxalates) is determined, stones (nephrolithiasis) are formed from calcium oxalate in the kidneys. The glomerular apparatus of the kidneys is damaged; when taking more than six hundred milligrams of ascorbic acid per day, moderate pollakiuria develops. In case of poisoning with ascorbic acid, capillary permeability decreases, tissue trophism worsens, blood pressure rises, hypercoagulation and microangiopathy develop.

Interaction with other drugs

When prescribing ascorbic acid with glucose together with antibiotics, it should be borne in mind that ascorbic acid significantly increases the concentration of tetracyclines and benzylpenicillins in the blood. When taking more than one gram per day of ascorbic acid with glucose, the bioavailability of ethinyl estradiol (including the one that is part of oral contraceptives) increases.

When taking ascorbic acid with glucose, the absorption of iron ions in the intestine improves. There may also be an increase in the excretion of iron preparations with the simultaneous use of ascorbic acid with a drug such as deferoxamine.

Ascorbic acid with glucose reduces the effectiveness of direct as well as indirect anticoagulants. With the combined intake of acetylsalicylic acid, oral contraceptives, fresh juices and alkalis, the absorption and assimilation of ascorbic acid is reduced.

At oral intake ascorbic acid increases the risk of developing crystalluria during treatment with salicylates and sulfa drugs short action. It also slows down the rate of excretion of acids by the kidneys, contributes to a more rapid withdrawal drugs that have an alkaline reaction (including alkaloids), and also significantly reduces the concentration of oral contraceptives in the blood.

When taking ascorbic acid, the total clearance of ethanol alcohol increases, which in turn reduces the level of ascorbic acid in the body. In high doses, ascorbic acid increases the excretion of mexiletin by the kidneys. Barbiturates may increase urinary excretion of ascorbic acid. Askorbinka reduces therapeutic effect neuroleptics - (antipsychotic drugs) phenothiazine derivatives. It also reduces tubular reabsorption of amphetamines as well as tricyclic antidepressants.

Special instructions and precautions

Due to the fact that ascorbic acid with glucose stimulates the synthesis of corticosteroid hormones, when taking it, it is necessary to monitor kidney function and regularly measure blood pressure. Since when using large doses of the drug for a long time, the function of the insular apparatus of the pancreas may be inhibited, during the treatment with ascorbic acid, it is necessary to regularly determine the level of glucose in the blood.

For patients with high iron content in the body, ascorbic acid with glucose should be used in minimal doses. It is not recommended to prescribe the drug to patients diagnosed with rapidly proliferating and metastatic tumors, since this can only aggravate the course of the process.

When conducting laboratory tests, it should be taken into account that the drug as a reducing agent can significantly distort the results. laboratory research. During the reception, the content of glucose in the blood, the activity of "liver" transaminases and LDH, as well as bilirubin may change.

Ascorbic acid with glucose during pregnancy and lactation can only be used if the intended benefit to the mother is much higher than the harm to the fetus and child. Such patients can take the drug only as prescribed by the doctor. In the second and third trimester of pregnancy, the daily requirement for ascorbic acid is 90 to 100 mg.

It should not be forgotten that the fetus can adapt to fairly high doses of ascorbic acid. This leads to the fact that subsequently the newborn sometimes develops a “withdrawal” syndrome. Ascorbic acid with glucose for children should be prescribed by a doctor. There is also a theoretical danger to the child when a nursing mother consumes high doses of the drug. The daily requirement for ascorbic acid of the mother during breastfeeding should in no way be exceeded. During lactation, a woman is recommended to take no more than 120 mg of the drug, so as not to harm the child.

Ascorbic acid, or ascorbic acid, is a well-known vitamin C. It is often taken during illness to activate the body's defenses. This biologically active substance takes part in all metabolic processes. daily requirement in ascorbic acid is 100 mg.

Sources of Vitamin C

An increased amount of ascorbic acid is found in citrus fruits, different varieties cabbage, rose hips, currants, apples, bell pepper, strawberries, tomatoes and persimmons.

Pharmaceutical vitamin preparations available in the form of tablets, lozenges and ampoules for injection. It is an overdose of such drugs that causes side effects on the body.

Why vitamin C is useful

Ascorbic acid is vital, its benefit is to activate the immune system. It also takes an active part in the process of hematopoiesis, improves the functionality of the nervous and endocrine systems.

Vitamin C is considered a powerful antioxidant free radicals from the body. Ascorbic acid is essential for growth and development connective tissue and collagen fibers. A sufficient level of this substance is effective prevention inflammatory and infectious diseases.

Energy generation of tissues human body also largely depends on ascorbic acid, which is involved in the synthesis of carnitine.

Indications for taking vitamin C tablets

In addition to the prevention of hypo- and beriberi, doctors recommend taking ascorbic acid in such cases:

• period of growth and puberty;
• pregnancy and breastfeeding;
• during difficult physical activity;
• a state of chronic overwork;
• recovery period after serious illness or injury;
• in winter and spring time to prevent the development of viral diseases;
• with acute and chronic blood loss;
• intoxication and degeneration of the body.

How to take vitamin C correctly

In order for ascorbic acid not to be harmful, it is necessary to remember about contraindications, symptoms of overdose and dosage vitamin preparations. In every pharmacy facility The recommended dosage is for children and adults.

Experts note that during pregnancy, ascorbic acid easily overcomes the placental barrier. In this regard, you should not use vitamin C in increased amount. Also Special attention the dosage of the drug should be given to women during the period breastfeeding. At this time, ascorbic acid can often cause allergic reactions in a child.

Reception pharmaceutical agent patients with chronic diseases urinary and of cardio-vascular system agreed with the attending physician, who, if necessary, will adjust the duration and dosage of the course of therapy.

Contraindications

An absolute contraindication to taking vitamin C is the presence of an allergic reaction to ascorbic acid in a patient. In such cases the patient has redness and itching skin . In more severe cases, a person suffers from swelling of the mucous membrane of the upper respiratory tract.

According to the instructions for the drug, special care should be taken by people with diabetes, anemic conditions and urolithiasis.

Pharmaceutical "ascorbic acid", the benefit or harm of which directly depends on the dosage, recommended to be taken orally after meals. For children, the dosage of the drug is usually half that for adult patients.

Excessive doses of vitamin C

For the first time about therapeutic effect ultra-high doses of ascorbic acid were mentioned by the American scientist L. Pauling, who studied the effect of vitamins on the course oncological diseases. In such cases, ascorbic acid greatly improves general well-being cancer patient.

If the drug is taken in preventive purposes many patients develop gastrointestinal complications. Ascorbic acid is harmful, it causes gastritis and ulcerative lesions mucous membrane of the gastrointestinal tract.

In 2000, at the World Congress of Cardiology, information was heard that high doses of vitamin C provoke atherosclerosis. Excessive intake of vitamin preparations by patients younger age may be accompanied allergic reactions and nephrological disorders.

The use of a vitamin remedy in combination with glucose

Pharmacy chains sell ascorbic acid with glucose. The benefit or harm of such a pharmaceutical product depends on the patient's compliance with the dosage. The features of this tool are that:

• artificially synthesized vitamin C is formed from glucose;
• the combined use of these two ingredients improves liver function;
• Glucose provides fast energy supply to the body.

Indications for the use of vitamin C and glucose

This tool is used in the cases listed below:

• The presence of symptoms of overwork, excessive irritability and chronic ailments.
• Signs of increased permeability blood vessels.
• Chronic periodontitis (inflammation of the mucous membrane of the periodontal tissues), bleeding gums.
• People who are in the group increased risk development of infectious diseases. In this case, the drug is recommended for children who often suffer from bacterial and viral diseases.
• Vitamin complex with glucose is useful at food poisoning as part of complex detoxification therapy.
• The tool is recommended for chronic pain in limbs, developmental disorders bone tissue and loose teeth.
• Formation of hemorrhagic diathesis.

Consequences of an overdose of vitamin C and glucose

Exceeding the norms for the use of ascorbic acid and glucose is accompanied by such complications:

• a sharp narrowing of the lumen of blood vessels due to thrombophlebitis and thrombosis;
• acute violation of the pancreas, which is manifested by the detection of glucose in the urine and a disorder of glycogen synthesis;
• dysfunction of the gastrointestinal tract frequent nausea, heartburn and pain attacks;
• In some cases, the patient has urticaria with hypersensitivity organism to ascorbic acid;
• long-term intake of vitamin C and glucose provokes the formation of kidney stones;
• progression of hypertension.

Medical care for patients with ascorbic acid poisoning

The first manifestation of an overdose is a violation of the digestive processes. The main principles of treatment in this case are:

• gastric lavage and the use of sorbents are effective in the first hours of poisoning due to the fact that ascorbic acid is rapidly absorbed through the gastric mucosa;
• immediate hospitalization of the patient, which is indicated even with allergic symptoms. The patient must be under constant medical supervision;
• symptomatic treatment of complications. Thus, for example, the presence of thrombi requires specific thrombolytic treatment to dissolve the blood clots;
• less aggressive action increased concentration ascorbic acid is achieved through the introduction of vitamins A and E. Such treatment requires constant medical monitoring.

Ascorbic acid in most cases is useful for the body. Side effect The drug is associated exclusively with an overdose of vitamin C.

Last update of the description by the manufacturer 31.07.1997

Filterable List

Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

Composition and form of release

1 vial with lyophilized powder for preparation injection solution contains ascorbic acid 0.05 g, complete with water for injection, in ampoules of 2 ml; in a package of 5 sets.

pharmachologic effect

Pharmacodynamics

Participates in the regulation of carbohydrate metabolism, redox processes, blood clotting, capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.

Indications of the drug Ascorbic acid with glucose

Avitaminosis and hypovitaminosis C; hemorrhagic diathesis, bleeding (nasal, pulmonary, hepatic, uterine, caused by radiation sickness); overdose of anticoagulants; infectious diseases and intoxication; Addison's disease, nephropathy of pregnant women; sluggishly healing wounds and bone fractures; dystrophy; mental and physical stress.

Contraindications

Hypersensitivity.

Side effects

Inhibition of the function of the insular apparatus of the pancreas (with prolonged use).

Dosage and administration

In / m, in / in, before administration, the lyophilized powder is dissolved in 1-2 ml sterile water for injection, adults - 1-3 ml of a 5% solution (2-6 ml of a 2.5% solution) per day; children - 1-2 ml of a 5% solution (2-4 ml of a 2.5% solution) per day.

Precautionary measures

Be wary appoint with increased blood clotting, thrombophlebitis, a tendency to thrombosis, diabetes. It is necessary to monitor renal function and blood pressure, especially when prescribing large doses.

Storage conditions of the drug Ascorbic acid with glucose

Keep out of the reach of children.

Shelf life of the drug Ascorbic acid with glucose

lyophilisate for solution preparation for intravenous and intramuscular injection 0.05 g - 2 years.

tablets 100 mg + 877 mg 100 mg + 877 - 1 year.

dragee 50 mg - 1.5 years.

Do not use after the expiry date stated on the packaging.

Instructions for medical use

Ascorbic acid with glucose
Instructions for medical use- RU No. LP-001199

Last Modified Date: 11.11.2011

Dosage form

Pills

Compound

1 tablet contains:

Active substance:

Excipients:

Calcium stearate - 10 mg, talc - 13 mg.

Description of the dosage form

Tablets of white color, ploskotsilindrichesky form, round, with a facet and risk.

Pharmacological group

pharmachologic effect

Ascorbic acid plays important role in the regulation of redox processes, carbohydrate metabolism, blood clotting processes, tissue regeneration, helps to increase the body's resistance to infections.

Dextrose (glucose) is involved in various metabolic processes in the body.

Indications

Prevention and treatment of hypo- and beriberi (scurvy). Ensuring the increased need of the body for vitamin C during the period of intensive growth, pregnancy, lactation, with intense physical and mental stress, stressful conditions during the recovery period after a long serious illness.

Contraindications

Hypersensitivity to the drug. High doses should not be given to patients with increased clotting blood, thrombophlebitis and a tendency to thrombosis; with diabetes mellitus and conditions accompanied by high blood glucose levels. Contraindicated in children under 6 years of age.

Carefully

Diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase; for use in high doses - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephrourolithiasis.

Use during pregnancy and lactation

Ascorbic acid crosses the placental barrier. It should be borne in mind that the fetus can adapt to the high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop ascorbic disease as a withdrawal reaction. Therefore, during pregnancy, ascorbic acid should not be taken in higher doses unless the expected benefit exceeds potential risk.

Ascorbic acid is released from breast milk. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent deficiency in baby. It is recommended that the nursing mother not exceed the maximum daily requirement for ascorbic acid, unless the expected benefit outweighs the potential risk.

Dosage and administration

The drug is taken orally after a meal.

For prophylactic purposes, adults take ½ (50 mg) - 1 (100 mg) tablet, children from 6 to 18 years old take ½ (50 mg) tablets per day.

IN medicinal purposes adults ½ (50 mg) - 1 (100 mg) tablet 3-5 times a day, children ½ (50 mg) - 1 (100 mg) 2-3 times a day.

The duration of treatment depends on the nature and course of the disease.

During pregnancy and lactation, 3 tablets per day for 10-15 days, then 1 tablet per day.

Side effects

Allergic reactions, irritation of the mucous membrane gastrointestinal tract (nausea, vomiting, diarrhea, spasm of the gastrointestinal tract); inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria): when used in high doses - hyperoxaluria and nephrocalcinosis (oxalate).

Changes in laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.

Overdose

Symptoms: when using more than 1 g - headache, increased excitability of the central nervous system, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract, inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria), hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day).

Decreased capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulability, development of microangiopathies).

Potentially if ingested toxic dose cause vomiting, rare cases- wash the stomach, prescribe Activated carbon laxatives (eg. isotonic solution sodium sulfate).

Interaction

Ascorbic acid: increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g / day, it increases the bioavailability of ethinylestradiol (including that which is part of oral contraceptives).

Improves absorption in the intestines of iron preparations (converts ferric iron to ferrous); May increase iron excretion when used concomitantly with deferoxamine.

Reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce absorption and assimilation.

When used simultaneously with acetylsalicylic acid the excretion of ascorbic acid in the urine increases and the excretion of acetylsalicylic acid decreases. Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%. Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Quinoline drugs, calcium chloride, salicylates, glucocorticosteroids with prolonged use deplete the reserves of ascorbic acid. With simultaneous use reduces the chronotropic effect of isoprenaline. With prolonged use or use in high doses, the interaction of disulfiram-ethanol can be disrupted.

In high doses, it increases the excretion of mexiletin by the kidneys.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

special instructions

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure.

With prolonged use of large doses, inhibition of the function of the insular apparatus of the pancreas is possible, therefore, in the course of treatment, it must be regularly monitored.

In patients with high iron content in the body, ascorbic acid should be used in minimal doses.

Appointment of ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the course of the process.

Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of "liver" transaminases and lactate dehydrogenase).

Information about possible impact medicinal product for medical use on the ability to administer vehicles, mechanisms

Does not affect the ability to drive vehicles and work with other mechanical means.

Release form

Tablets (100 mg + 877 mg).

10 tablets in a blister pack or in a blister pack. 1, 2, 5 blister packs or blister packs with instructions for use are placed in a pack. Boundary cellless packages are placed in a group package with an equal number of instructions for use.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 ° C.

Keep out of reach of children.

Best before date

Do not use after the expiration date.

Terms of dispensing from pharmacies

Without a doctor's prescription.

Ascorbic acid with glucose - instructions for medical use - RU No. LP-000311 dated 2018-03-12

Synonyms of nosological groups

Content:

What is the composition of ascorbic acid with glucose. What effect does this drug have on the body and how to take it correctly.

According to doctors, glucose with vitamin C is a good combination that provides a greater effect on the body in terms of strengthening the immune system and normalizing metabolic processes.

Glucose works in the following way:

• Participates in metabolism. This element has been proven to be easily absorbed and improves metabolic processes. With the appearance of glucose deficiency, a person experiences drowsiness and weakness.
• Stimulates the work of the heart muscle. Glucose has a positive effect on the heart, which explains the popularity of the element in the treatment of diseases associated with this organ.
• Provides the body with energy. Thanks to glucose, living tissues quickly compensate for the deficiency. useful substances. A person engaged in physical activity, actively restores efficiency.
• Used to treat intoxication body and hypoglycemia, is contained in many medicines used to treat the liver and central nervous system.
• Normalizes brain function. It has been proven that the "gray matter" feeds on energy, which is obtained from carbohydrates. Lack of glucose leads to lethargy and dispersal.
• Relieves stress. After entering the blood, glucose corrects mental condition, provides a sense of stability and calmness.
• Decreases the feeling of hunger.

Like glucose, vitamin C has a multifaceted effect on the body:

• Participates in the formation of collagen fibers, heals damage and wounds on the body.
• Normalizes redox processes.
• Cleans blood vessels, reduces their permeability, makes them strong and elastic.
• Participates in hematopoiesis, helps in the absorption of iron, stimulates the production of hemoglobin.
• Has a general strengthening effect, strengthens immune system, acts as prophylactic with flu and colds.
• Participates in metabolic processes. Ascorbic acid enhances the action of vitamin E and promotes the synthesis of carnitine.

Form and composition

Ascorbic acid with glucose - widely famous drug which comes in the form of tablets. Compound:

• Ascorbic acid (vitamin C) - 100 mg.
• Glucose - 0.877 g.
• Additional elements - talc, starch, stearic acid.

Tablets are flat-cylindrical in shape, made in white.

Pharmacodynamics

Joint intake of glucose and ascorbic acid is more effective. At the same time, the drug has a multifaceted effect:

• Participates in metabolic processes.
• Regulates redox functions.
• Normalizes carbohydrate metabolism and improves blood clotting.
• Accelerates the restoration of living tissues.
• Optimizes the synthesis of steroid hormones.
• Strengthens the body's immune system and makes it resistant to infectious diseases.
• Reduces vascular permeability and reduces the body's need for a group of vitamins: B1, B2, tocopherol, retinol, B9 and pantothenic acid.

Pharmacokinetics

Vitamin C is absorbed into the blood in the jejunum and duodenum. Half an hour after admission, the level of ascorbic acid in the blood rises and it is captured by tissues, followed by conversion to dehydroascorbic acid. The latter tends to penetrate cell membranes and quickly recover in the body.

Inside the cells, vitamin C is found in 3 forms of acids:

• ascorbic;
• dehydroascorbic;
• ascorbigen.

After absorption, the element is unevenly distributed in living tissues. Most of accumulates in the endocrine glands (in the adrenal glands), and to a lesser extent - in the skeleton and heart muscle. Vitamin C also accumulates in the liver and kidneys. 90% of ascorbic acid is metabolized and excreted through the kidneys in two forms - free or in the form of oxalate.

Glucose easily absorbed into living cells of the body, and the main ways for metabolic processes is aerobic oxidation and glycolysis. The result of the process is the release of water with the release of ATP, as well as the formation of CO2.

The instructions for use of ascorbic acid with glucose indicate that the drug appointed in the following cases:

• With beriberi or hypovitaminosis of element C.
• With a high need of the body for ascorbic acid, namely during a period of high physical exertion, while feeding a child, during pregnancy, during active growth and during the period of convalescence (recovery after serious illnesses).

Contraindications

Despite positive traits, a drug Not recommended to be accepted in the following cases:

• The presence of hypersensitivity to one of the elements of the drug.
• Children's age up to six years.
• Tendency to thrombosis.
• Thrombophlebitis.

Vitamin C with glucose is prescribed, but with caution:

• Lack of glucose-6-phosphate dehydrogenase caused by body disorders.
• Diabetes.

Special attention is paid, when prescribing the drug in large doses, to such diseases:

• hemochromatosis;
• sideroblastic anemia;
• hypoxaluria;
• nephrourolithiasis;
• thalassemia.

Dosage and methods of administration

The drug is taken orally. The duration of the course and the optimal dosage is determined by the doctor. Recommendations for taking vitamin C and glucose are as follows:

1. For preventive purposes:
   • Adults - 50-100 mg in a day.
   • Children under 14 - 50 mg in a day.
   • Children after 14 years - 50-75 mg in a day.
2. During treatment:
   • Adults - 50-100 mg. The drug is taken three times a day.
   • Children (from 6 years old) - 50-100 mg. Frequency of reception - 2-3 times a day.
3. During pregnancy and in postpartum period - 300 mg in a day. Course - 10-15 days. Further, the drug is taken for the prevention of 100 mg per day until the moment the baby is breastfeeding.

In the process of receiving a series of side effects , among which:

• From the side of the insular apparatus - glucosuria, hyperoxaluria.
• Allergic reactions - the appearance of rashes on the skin, irritation of the mucous membrane.
• From the gastrointestinal tract - vomiting, nausea, severe cramps, diarrhea.
• Impact on results laboratory tests- leukocytosis, hyperprombinemia, thrombocytosis, neurophilic leukocytosis, aerotropenia.

Individual instructions

Glucose and vitamin C stimulate the production of corticosteroid hormones in the body, therefore, during the entire course of taking the drug, it is recommended to monitor the work of the kidneys and pressure circulatory system. In the case of prolonged use, the risk of inhibition of the pancreas increases, which requires additional control of this factor. Otherwise, the risk of exacerbation in diabetic patients is high.

People who have high level iron in the body should limit the intake of vitamin C. In addition, the drug is not prescribed to patients with actively developing metastases, which leads to a violation (aggravation) of the process. Before testing, it is required to warn the laboratory about taking the drug due to the effect of the latter on the results (this was mentioned above).

Patients with diabetes should be aware that one tablet of the supplement contains 0.08 bread units, and in a daily portion (4-5 tablets) - almost 0.4 bread units . This point is important to take into account in the process of planning a diet.

Taking the drug does not affect the ability to drive a car. There are also age restrictions. So, vitamin C with glucose is not recommended for children under the age of six. In other cases, the appointment is allowed, but subject to strict adherence to the dosage and recommendations of the doctor.

Taking the drug during pregnancy and lactation

Glucose and vitamin C are often prescribed to women during childbearing and lactation. The drug is recommended by a doctor in a situation where the benefit to the mother is higher than potential danger for a child. During the period of gestation, vitamin C with glucose is used only for its intended purpose.

Minimum requirement female body in ascorbic acid in the second and third trimester is 0.09-0.1 grams per day. In the process of taking it, it is worth considering that the fetus quickly adapts to a high dosage of the substance entering the body, which is why after birth the baby has a risk of developing the “withdrawal” syndrome. It is not recommended to exceed the dosage during the feeding period due to the potential risk to the health of the child. The minimum rate during lactation is 0.12 grams.

During the period of taking the drug, the following should be taken into account interaction features:

• In the case of the intake of vitamin C in a volume of more than 1 gram per day, the bioavailability of ethinylestradiol (a substance that is part of oral contraceptives) increases.
• Under the action of ascorbic acid, the concentration of tetracyclines and benzylpenicillin in the blood increases.
• The absorption of iron in the body increases, and the level of excretion of the trace element increases in case of simultaneous reception vitamin C with deferoxamine.
• The risk of developing crystalluria increases during treatment with short-acting sulfonamides and salicylates. At the same time, the rate of removal of acids from the body slows down, and the withdrawal of drugs from alkaline reaction, on the contrary, is accelerating. For this reason, while taking ascorbic acid, the effect of oral contraceptives is suppressed.
• The effect of indirect anticoagulants and heparin is reduced.
• When combined with oral contraceptives, fresh juices, alkaline drink and acetylsalicylic acid worsens the absorption and absorption of vitamin C.
• In high dosage, the rate of excretion of mexiletin by the kidneys increases.
• The total clearance of ethanol increases, which reduces the concentration of vitamin C in the body.
• The therapeutic effect of antipsychotropic drugs - tubular reabsorption of amphetamine, phenothiazine derivatives - is reduced.

Dangers of overdose

A drug should be taken at the dosage recommended by the doctor. Otherwise, a number of side effects are possible.

If the daily intake exceeds 1 gram per day, then the body reacts as follows:

• increased excitability of the central nervous system;
• headache;
• diarrhea;
• vomit;
• nausea;
• glycosuria and hyperglycemia;
• ulceration of the mucous membrane;
• nephrolithiasis;
• violation of the glomerular renal apparatus;
• pollakiuria (at a dosage of 600 mg per day);
• increase in blood pressure;
• development of microangiopathy;
• deterioration of vascular permeability.

Packaging and storage conditions

The drug is available in cell bags or non-cell contour packs made of cardboard. The number of tablets is 10 pieces.

Storage requirements:

• exclusion of the rays of the sun on the packaging;
• temperature up to 25 degrees heat;
• inaccessibility for children;
• normal humidity ( up to 60%).

The shelf life under the above conditions is one year. After the expiration date, the drug is prohibited. The supplement is released in a pharmacy without a prescription, but in order to avoid health problems, a doctor's recommendation before taking is required.