Thiamine chloride solution for intramuscular injection. Medicinal reference book geotar. What are the side effects

Injection.

Pharmacological group

Drugs affecting the digestive system and metabolism. Vitamins. Vitamin 1 preparations.

Indications

Hypo- and avitaminosis B 1 (including H. In patients on tube feeding, on hemodialysis, suffering from malabsorption syndrome). As part of complex therapy: neuritis, polyneuritis, sciatica, neuralgia, peripheral paresis and paralysis, diabetic neuropathy, Wernicke-Korsakoff encephalopathy, chronic alcoholism, alcoholic neuropathy, chronic liver damage, intoxication of various etiologies, myocardial dystrophy, coronary circulation disorder, gastric ulcer and duodenal ulcer, atonic constipation, intestinal atony, thyrotoxicosis, diabetes mellitus, endarteritis, dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neutrophic with mines and metabolic disorders. Prolonged physical and mental stress.

Contraindications

Hypersensitivity to the components of the drug. Allergic diseases, idiosyncrasy, premenopausal and menopausal periods in women.

Dosage and administration

Assign intramuscularly (deep into the muscle), intravenously (slowly) and subcutaneously (rarely).

For administration, a single dose is diluted in 10 ml of a 0.9% sodium chloride solution and administered over 1 to 3 minutes.

The introduction begins with small doses (no more than 0.5 ml for adults), higher doses are administered only with good tolerance.

Adults appoint 25 - 50 mg (0.5 - 1 ml) 1 time per day, daily. The course of treatment is 10 - 30 days.

With Wernicke-Korsakov encephalopathy, 50-100 mg (1-2 ml) are prescribed intramuscularly 2 times a day for clinical improvement. The likelihood of developing an allergic reaction to the administration of vitamin B 1 should be taken into account.

Children from 1 year old are prescribed 12.5 mg (0.25 ml) 1 time per day, daily. The course of treatment is 10 - 30 days.

The dose and duration of treatment are set individually, depending on the therapeutic effect, the nature of complex therapy, and the tolerance of the drug.

Adverse reactions

Allergic reactions are possible: itching, urticaria, angioedema, difficulty swallowing and breathing; rarely - collapse, paresthesia, sweating, tachycardia, angioedema; very rarely - anaphylactic shock. These reactions occur with a tendency to allergies, in women in menopausal and pre-menopausal periods, in patients with alcoholism;

optic nerve lesions intestinal hemorrhage; attacks of bronchial asthma the phenomenon of synaptoplegia - the ability of thiamine to form complexes with various mediators - a drop in blood pressure, the occurrence of cardiac arrhythmias, impaired contraction of skeletal, including respiratory, muscles, depression of the central nervous system.

Vitamin B 1 can disrupt the activity of liver enzymes.

Overdose

Symptoms: it is possible to increase the symptoms of side effects of the drug.

Treatment: withdrawal of the drug, symptomatic therapy.

Use during pregnancy or lactation

Use during pregnancy or lactation is possible. There are no data on the penetration of thiamine into breast milk.

Children

It is used in children from 1 year.

Application features

With caution appoint with increased excitability of the nervous system, hyperacid forms of duodenal ulcer.

The injectable form of the drug should be used in the treatment of patients with malabsorption in the intestine or with resection of the stomach, if it is impossible to take thiamine in

tablet form (nausea, vomiting, pre- and postoperative period), as well as in severe forms of the disease or at the beginning of treatment to achieve a therapeutic effect more quickly. It is recommended to start parenteral administration with small doses (no more than 0.5 ml for adults), and only with good tolerance, higher doses are administered.

With the introduction of the drug should be injected deep into the muscle, with intravenous - slowly.

Subcutaneous and sometimes intramuscular injections are painful due to the low pH of the solution.

In women in menopausal and premenopausal periods, as well as in patients with alcoholism, the symptoms of side effects of the drug may increase.

Do not use the drug as a substitute for a balanced diet.

If an allergy to vitamin B 1 is detected, rice, buckwheat, meat, bread (containing wholemeal flour) are excluded from the patient's diet.

Daily requirement for vitamin B 1: for adult men - 1.2 - 2.1 mg, for the elderly - 1.2 - 1.4 mg, for women - 1.1 - 1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg for women during lactation, for children, depending on age - 0.3 - 1.5 mg.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms

During treatment, care should be taken when driving vehicles and working with mechanisms.

Interaction with other medicinal products and other forms of interaction

Simultaneous parenteral administration of thiamine chloride with vitamin B 6 (pyridoxine) and vitamin B 12 (cyanocobalamin) is not recommended, since the former makes it difficult to convert thiamine into an active form, and the latter enhances the allergenic effect of thiamine.

Thiamine weakens the effect of depolarizing muscle relaxants (suxamethonium).

Long-term treatment with anticonvulsants (phenobarbital, phenytoin, carbamazepine), as well as combined use with digoxin, indomethacin, antacids, can lead to thiamine deficiency. Thiosemicarbazone and 5-fluorouracil inhibit vitamin 1 activity. The use of caffeine, preparations containing sulfur and estrogens increases the need for thiamine.

Pharmacological properties

Pharmacological. Thiamine chloride - a synthetic preparation of vitamin 1 refers to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is the coenzyme of many enzymatic reactions. Vitamin B 1 plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation in synapses. Vitamin B 1 has a restorative, metabolic, immunomodulatory, antioxidant, n-anticholinergic effect.

active substance: thiamine;

1 ml of solution contains thiamine chloride in terms of 100% substance 50 mg;

Excipients: unitiol, water for injections.

Dosage form

Injection.

Pharmacotherapeutic group

Drugs affecting the digestive system and metabolism. Vitamins. Vitamin B1 preparations.

ATC code A11D A01.

Indications

Hypo - and avitaminosis B 1 (including in patients on tube feeding, on hemodialysis, suffering from malabsorption syndrome). As part of complex therapy: neuritis, polyneuritis, sciatica, neuralgia, peripheral paresis and paralysis, diabetic neuropathy, Wernicke-Korsakoff encephalopathy, chronic alcoholism, alcoholic neuropathy, chronic liver damage, intoxication of various etiologies, myocardial dystrophy, coronary circulation disorder, gastric ulcer and duodenal ulcer, atonic constipation, intestinal atony, thyrotoxicosis, diabetes mellitus, endarteritis, dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neutrophic changes and metabolic disorders. Prolonged physical and mental stress.

Contraindications

Hypersensitivity to the components of the drug. Allergic diseases, idiosyncrasy, premenopausal and menopausal periods in women.

Dosage and administration

Assign intramuscularly (deep into the muscle), intravenously (slowly) and subcutaneously (rarely).

For intravenous administration, a single dose is diluted in 10 ml of 0.9% sodium chloride solution; enter within 1 - 3 min.

The introduction begins with small doses (no more than 0.5 ml for adults), higher doses are administered only with good tolerance.

Adults appoint 25 - 50 mg (0.5 - 1 ml) 1 time per day, daily. The course of treatment is 10 - 30 days.

With Wernicke-Korsakov encephalopathy, 50-100 mg (1-2 ml) are prescribed intramuscularly 2 times a day until clinical improvement. The likelihood of developing an allergic reaction to the administration of vitamin B 1 should be taken into account.

Children from 1 year old are prescribed 12.5 mg (0.25 ml) 1 time per day, daily. The course of treatment is 10 - 30 days.

The dose and duration of treatment are set individually, depending on the therapeutic effect, the nature of complex therapy, and the tolerance of the drug.

Adverse reactions

Possible allergic reactions: itching, urticaria, angioedema, difficulty swallowing and breathing; rarely - collapse, paresthesia, sweating, tachycardia, angioedema; very rarely - anaphylactic shock. These reactions occur with a tendency to allergies, in women in menopausal and pre-menopausal periods, in patients with alcoholism;

damage to the optic nerve; intestinal hemorrhage; attacks of bronchial asthma; the phenomenon of synaptoplegia - the ability of thiamine to form complexes with various mediators - a drop in blood pressure, the occurrence of cardiac arrhythmias, impaired contraction of skeletal, including respiratory, muscles, depression of the central nervous system.

Vitamin B 1 can disrupt the activity of liver enzymes.

Overdose

Symptoms: may increase the symptoms of side effects of the drug.

Treatment: drug withdrawal; symptomatic therapy.

Use during pregnancy or lactation

Use during pregnancy or lactation is possible. Data on the penetration of thiamine into breast milk are not available.

Children

It is used in children from 1 year.

Application features

With caution appoint with increased excitability of the nervous system, hyperacid forms of duodenal ulcer.

The injectable form of the drug should be used in the treatment of patients with malabsorption in the intestine or with resection of the stomach, if it is impossible to take thiamine in

tablet form (nausea, vomiting, pre- and postoperative period), as well as in severe forms of the disease or from the beginning of treatment to achieve a therapeutic effect more quickly. It is recommended to start parenteral administration with small doses (no more than 0.5 ml for adults), and only with good tolerance, higher doses are administered.

With intramuscular injection, the drug should be injected deep into the muscle, with intravenous injection - slowly.

Subcutaneous and sometimes intramuscular injections are painful due to the low pH of the solution.

In women in menopausal and premenopausal periods, as well as in patients with alcoholism, the symptoms of side effects of the drug may increase.

Do not use the drug as a substitute for a balanced diet.

If an allergy to vitamin B 1 is detected, rice, buckwheat, meat, bread (containing wholemeal flour) are excluded from the patient's diet.

Daily requirement for vitamin B 1: for adult men - 1.2 - 2.1 mg, for the elderly - 1.2 - 1.4 mg, for women - 1.1 - 1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg for women during lactation, for children, depending on age, - 0.3 - 1.5 mg.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms

During treatment, care should be taken when driving vehicles and working with complex mechanisms.

Interaction with other medicinal products and other forms of interaction

Simultaneous parenteral administration of the drug Thiamine chloride vitamin B 6 (pyridoxine) and vitamin B 12 (cyanocobalamin) is not recommended, since the first makes it difficult to convert thiamine into an active form, and the second enhances the allergenic effect of thiamine.

Thiamine weakens the effect of depolarizing muscle relaxants (suxamethonium).

Long-term treatment with anticonvulsants (phenobarbital, phenytoin, carbamazepine), as well as combined use with digoxin, indomethacin, antacids, can lead to thiamine deficiency. Thiosemicarbazone and 5-fluorouracil inhibit the activity of vitamin B 1 . The use of caffeine, preparations containing sulfur and estrogens increases the need for thiamine.

Pharmacological properties

Pharmacodynamics. Thiamine Chloride - a synthetic preparation of vitamin B 1 refers to water-soluble vitamins. In the human body, due to phosphorylation processes, it turns into cocarboxylase, which is the coenzyme of many enzymatic reactions. Vitamin B 1 plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of nerve excitation in synapses. Vitamin B 1 has a restorative, metabolic, immunomodulatory, antioxidant, n-anticholinergic effect.

Pharmacokinetics. The drug is well absorbed. Phosphorylation occurs in the liver. Accumulates in the liver, heart, brain, kidneys, spleen. It is excreted by the liver and kidneys, approximately 8 - 10% - unchanged.

Basic physical and chemical properties

clear, colorless or slightly yellowish liquid.

Incompatibility

A solution of Thiamine Chloride should not be mixed with solutions containing sulfites, as it completely decomposes in them; with penicillin or streptomycin (destruction of antibiotics) and with nicotinic acid (destruction of thiamine occurs).

Best before date

Storage conditions

To store in the place protected from light at a temperature from 15 °C to 25 °C.

Keep out of the reach of children!

Package

1 ml in ampoules; 10 ampoules in a cardboard box

What kind of vitamin is thiamine chloride, how are injections with ampoules used and how is it useful for hair? You will learn all this and much more in this guide. Thiamine chloride is vitamin B1.

It belongs to the vitamins that are synthesized into cocarboxylase. Performs metabolic processes in the body - actively participates in the metabolism of carbohydrates, proteins and fats.

Thiamine chloride instructions for use

Thiamine chloride instructions for use injections

Ampoules are administered intramuscularly (deep into the muscle!).

• For adults- 0.025-0.05 g (1 ml of 2.5% or 5% solution);
• For kids- 0.0125 g (0.5 ml of a 2.5% solution);

The dose is administered once a day. The entire course of treatment takes 10-30 days.

• AtWernicke-Korsakoff encephalopathy- 0.05 - 0.1 g (1-2 ml) 2 times a day. Take until clinical improvement. After prolonged use, allergic reactions are possible.

Thiamine chloride for hair

Vitamin B1 provides hair follicles with proteins, fats, carbohydrates, minerals and biologically active substances. Once in the body, thiamine stimulates the transport of energy substrates to the scalp. Lack of vitamin B1 will quickly affect the general condition of the hair. How to use thiamine chloride for hair?

Compound

1ml solution contains active ingredient thiamine(Vitamin B1) — colorless, slightly yellowish transparent liquid.

Excipients: water for injection, unithiol.

Release form

The drug is available as a ready-made solution for injections of 2.5% and 5%.

Packed in ampoules of 1 ml. 10 ampoules in a carton.

pharmachologic effect

Co-fermentation of the most important enzymes without this drug is impossible. They catalyze carbohydrate metabolism. The vitamin product has a positive effect on the nervous system, reduces excitation by influencing the region of neuromuscular synapses. Responsible for protecting the membrane of cells that are toxically affected by oxidation products.

Pharmacodynamics and pharmacokinetics

Suction- a high percentage of absorption throughout the small intestine. Digestive enzymes are pre-released before absorption of the drug. The concentration of the medicinal product in the blood is low.

Distribution- free thiamine is released in plasma, and phosphorus esters in leukocytes and erythrocytes. Half of the substance settles in the muscle tissues and only 40% on the internal organs.

Metabolism- Phosphorylation reaction occurs in the liver. Perhaps this is due to coenzyme activity. The largest amount of the drug accumulates in the internal organs, as well as in the brain.

Displayed passing through the kidneys and intestines.

Indications for use

Appointcabinsat:

• Lack of vitamin B1;
• Neuralgia, sciatica, neuritis, peripheral paralysis;
• Ulcer of the stomach and duodenum;
• problems with the liver;
• Encephalopathies of Wernicke-Korsakov.
• myocardial dystrophy;
• pyoderma;
• eczema;
• Psoriasis.

Contraindications

• High sensitivity to Vitamin B1;
• Allergic manifestations;
• Idiosyncrasy;
• In the climatic and pre-climatic period in the weaker sex.

Take with caution when:

• Increased nervousness;
• Peptic ulcer of the duodenum.

Side effects

Thiamine chloride can cause allergic reactions:

• Hives;
• Complicated breathing and swallowing;
• Quincke's edema.

In rare cases:

• Tachycardia;
• sweating;
• Collapse;
• Angioedema;
• Anaphylactic shock is very rare.

Side effects of the drug also include:

• Intestinal hemorrhage;
• Damage to the optic nerve;
• Symptoms of bronchial asthma;
• Jumps in blood pressure;
• cardiac arrhythmias;
• Failure of the nervous system.

special instructions

• Other vitamins, for example: B12 and B6
• Combine with solutions of the sulfate group. Such actions will lead to the complete disintegration of the drug.

Thiamine chloride in ampoules is actively used for hair, in its pure form, it is not recommended to apply it to the hair. Allergic effects may occur. The drug must be added to masks, hair balms, etc.

To avoid low levels of vitamin B1 in the body, it is worth reviewing your daily diet. Most of the useful component is found in fatty meat, oatmeal, buckwheat, peas and nuts. Do not forget about wholemeal flour, rice bran, green vegetables.

Interaction

The simultaneous use of thiamine chloride with other medicinal components leads to the following consequences:

1. Pyridoxine makes it difficult to absorb the drug, and Cyanocobalamin, on the contrary, enhances its effect.
2. The drug weakens the effect on the body of depolarizing muscle relaxants
3. Long-term treatment with phenytoin, phenobarbital, and carbamazepine may cause thiamine deficiency.
4. The use of caffeine, as well as substances that contain sulfur or estrogens, increase the need for vitamin B1.
5. The drug should not be taken in conjunction with analogues that contain sulfites, drugs based on penicillin, as well as with nicotinic acid. Under their influence, the destruction of thiamine occurs.

Overdose

"Thiamin chloride" is a synthetic preparation of vitamin B1, which belongs to water-soluble vitamins and is converted into cocarboxylase in the body. And already it is a coenzyme of enzymatic reactions. The specified vitamin takes an active part in protein, as well as fat and carbohydrate metabolism.

"Thiamin chloride" is taken parenterally, so it quickly enters the bloodstream and is further distributed between tissues and organs. The process of phosphorylation occurs in the liver, after which it accumulates in the heart, liver, kidneys, brain, spleen. About 10% of this vitamin is excreted unchanged from the patient's body through the kidneys and liver.

Indications for the use of this remedy

"Thiamin chloride" is a vitamin, and it is prescribed in the presence of beriberi or hypovitaminosis B1, as well as for encephalopathy, neuritis, peptic ulcer of the stomach, neurasthenia, peripheral paralysis, polyneuritis, peptic ulcer of the duodenum. It is also prescribed in the presence of liver diseases, spasms of peripheral vessels, eczema, dermatosis of neurogenic origin, intestinal atony, neuralgia, psoriasis, pyoderma and skin itching.

"Thiamin chloride" - instructions for use

A 5% solution of this drug for adults and children is administered 1 time during the day, the procedure is carried out daily. For children, the daily dose is not more than 0.25 ml, and for adults, 1 ml of the indicated solution. Usually the course of treatment with the drug is from 10 to 30 injections.

Possible side effects

The use of "Thiamin chloride" can cause allergic reactions, and sometimes patients who are prone to allergies and have a history of allergic reactions to B vitamins are most susceptible to their occurrence.

Contraindications

The drug should not be taken in case of hypersensitivity, hypertension, as well as in the presence of allergic diseases and idiosyncrasy. Carefully it is necessary to take "Thiamin chloride" to people who have an increased excitability of the nervous system and hyperacid forms of duodenal ulcer.

Do not allow mixing of the specified drug with solutions that include sulfites. This leads to the fact that "Thiamin chloride" in them completely decomposes. It is also not recommended to take this vitamin along with vitamins B6 and B12.

Overdose

If this drug is taken in high doses and for a fairly long period of time, symptoms such as headache, tremor, agitation, insomnia and enlargement may develop. Usually, after stopping this drug, all these symptoms disappear on their own, but if necessary, symptomatic treatment should be carried out. treatment.

Injections are carried out to obtain a faster result, as well as for patients who have intestinal disorders. But it is recommended to start with small doses of the drug, they should not exceed 0.5 ml of a 5% solution, if the drug is well tolerated, then its dose is adjusted to the recommended amount. If the drug is administered intravenously, then this should be done very slowly, and if into the muscle, then deeply. When carrying out injections, slight painful sensations can sometimes occur, which is explained by the low pH of the solution. Alcoholics and women who are in menopausal and pre-menopausal periods may experience increased side effects.

It is not recommended to mix "Thiamin chloride" in the same syringe with streptomycin or penicillin, since the antibiotic is destroyed, and also to mix it with nicotinic acid, since thiamine is destroyed.

The drug "Thiamin chloride" is vitamin B1, necessary for fat, protein, carbohydrate metabolism and conduction processes in the synapses of nervous excitation. In the human body, this water-soluble vitamin is converted due to phosphorylation processes into cocarboxylase, which is the coenzyme of various enzymatic reactions. Means "Thiamin chloride" is used in the treatment of beriberi, hypovitaminosis B1, polyneuritis, neuritis, peripheral paralysis, neurasthenia, neuralgia, sciatica. In addition, it is used for the treatment of peptic ulcers, liver diseases, intestinal atony, endarteritis, myocardial dystrophy, dermatoses of neurogenic origin. The drug "Thiamin chloride" is prescribed for skin itching, psoriasis, eczema, pyoderma.

Release form. Compound

The drug is produced in the form of a solution for injection in ampoules in the amount of 10 pieces in one package. In terms of a 100% substance, 1 ml of the product contains 50 mg of thiamine chloride. Auxiliary ingredients are water and unithiol.

Mode of application

The drug "Thiamin chloride" instruction shows to administer intramuscularly, intravenous administration is also allowed. Adults are prescribed a daily dosage of 5% solution - 1 ml, children - 0.25 ml. Initially, it is recommended to make parenteral administration in small doses, only if the drug is well tolerated, increase the dosage. The therapeutic course involves the implementation of 10 to 30 injections. With intramuscular injections, the drug should be injected deep into the muscle (the injection can be quite painful), and with intravenous injections, very slowly.

Side effects

Urticaria, pruritus, Quincke's edema, anaphylactic shock may occur. Such negative phenomena can occur when the patient is prone to allergies, in the pre-menopausal and menopausal period in women, in patients suffering from alcoholism.

Contraindications

It is worth refusing to use the drug "Thiamin chloride" in case of hypersensitivity to the components included in the composition, allergic pathologies, hypertension, idiosyncrasy. The drug is prescribed with increased caution in duodenal ulcer, which has a hyperacid form, high excitability of the nervous system.

Use during pregnancy, lactation

Negative effects during the use of the drug by pregnant and lactating women have not been identified, therefore, therapy with "Thiamin chloride" for this category of patients is allowed.

When using the drug in excess doses, side effects may increase. If you use the drug in high doses for a long time, there is a possibility of symptoms of hyperthyroidism: tremor, insomnia, headache, increased heart rate.

Interaction with other drugs

It is impossible to mix the agent with solutions containing sulfites, because the thiamine chloride substance decomposes in them, as well as with penicillin (the antibiotic is destroyed) and nicotinic acid (thiamine is destroyed).