Nurofen from 6 years old instructions for use. Control of laboratory indicators. Use during pregnancy and lactation

Latin name

Nurofen for Children

Release form

Coated tablets.

One coated tablet contains the active substance - 200 mg of ibuprofen and excipients: sodium croecarmellose, sodium lauryl sulfate, sodium citrate dihydrate, stearic acid, colloidal silicon dioxide, sodium carmellose, talc, acacia gum, sucrose, titanium dioxide, macrogol 6000, black ink (shellac, black iron oxide E) 72, polypropylene glycol, isopropyl alcohol, n-butyl alcohol, methylated industrial alcohol, purified water).

Package

pharmachologic effect

Nurofen is a pesticide anti-inflammatory drug (NSAID). It has a directed action against pain, has antipyretic and anti-inflammatory properties. The mechanism of action of ibuprofen is due to the inhibition of the synthesis of prostaglandins mediators of pain, inflammation and hyperthermic reaction.

Indications

Nurofen is used for headache and toothache, migraine, painful menstruation, neuralgia, back pain, muscle and rheumatic pain; as well as febrile

For flu and colds.

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract and the acute phase, including peptic ulcer of the stomach and 12 duodenal ulcer in the acute stage, ulcerative colitis, peptic ulcer, Crohn's disease;
heart failure;
severe course of arterial hypertension;
hypersensitivity to ibuprofen or to the components of the drug;
complete or incomplete syndrome of acetylsalicylic acid intolerance (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
diseases of the optic nerve; color vision disorder, amblyopia, scotoma;
deficiency of glucose-6-phosphate dehydrogenase, hemophilia and other blood clotting disorders, hemorrhagic diathesis, hypocoagulation conditions;
pregnancy III trimester, lactation period;
severe liver dysfunction;
severe renal failure (creatipip clearance less than 30 ml / min);
hearing loss, pathology of the vestibular apparatus;
period after coronary artery bypass grafting;
gastrointestinal bleeding and intracranial hemorrhage;
hemophilia and other blood clotting disorders, hemorrhagic diathesis;
children under 6 years old.

With caution: old age, coronary heart disease, cerebrovascular disease, dyslipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol use, long-term use of HDL, severe somatic diseases, concomitant use of oral corticosteroids (including prediizolone), anticoagulants ( including warfarin, clopidogrel, acetylsalicylic acid), taking selective serotonin reuptake inhibitors, diseases while taking the drug in patients with a history of gastric ulcer and 12 duodenal ulcer, with gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract; in the presence of concomitant diseases of the liver and / or kidneys; with cirrhosis of the liver with portal hypertension, nephrotic syndrome, chronic heart failure; arterial hypertension; with blood diseases of unclear etiology (leukopenia and anemia); with bronchial asthma, with hyperbilirubinemia; pregnancy (I, II trimesters); age under 12 years old.

Use during pregnancy and lactation

Nurofen is not prescribed during pregnancy, lactation and children weighing less than 7 kg.

Dosage and administration

Nurofen is prescribed for adults and children over 12 years old by mouth, after meals in tablets of 200 mg 3-4 times a day. The tablets should be taken with water.

To achieve a rapid therapeutic effect in adults, the dose may be increased to 400 mg (2 tablets) 3 times a day.

Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can only be used if the child weighs more than 20 kg. The interval between taking the tablets is at least 6 hours. Do not exceed 6 tablets in 24 hours. The maximum daily dose is 1200 mg. IF symptoms persist after taking the drug for 2-3 days, stop treatment and consult a doctor.

Side effects

From the digestive system: nausea, vomiting, discomfort or pain in the epigastrium, diarrhea, erosive and ulcerative lesions of the mucous membrane and bleeding from the gastrointestinal tract.
Allergic reactions: skin rash, itching, urticaria, exacerbation of bronchial asthma.
From the side of the central nervous system: headache, dizziness.
From the urinary system: impaired renal function.
On the part of the hematopoietic organs: anemia, thrombocytopenia, agranulocytosis, leukopenia.

special instructions

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodeposcopy, complete blood count (hemoglobin determination), fecal occult blood analysis. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. Freemen must refrain from all types of activities that require increased attention, quick mental and motor reactions. During the treatment period, you should refrain from drinking alcohol.

drug interaction

Receiving low doses of acetylsalicylic acid (ASA) as an antiplatelet agent after starting ibuprofen). 1 When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokipase), the risk of bleeding increases at the same time. Cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin, increase the purity of the development of hypoprothrombinemia. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, fepilbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions. Microsomal oxidation inhibitors - reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiaggregants, fibrinolytics. Enhances the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs, sulfonylurea and insulin derivatives. Antacids and cholestyramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

INSTRUCTIONS
on the medical use of the drug

Registration number: P N013012/01-100511

International non-proprietary name (INN): ibuprofen

Chemical Name:(RS)-2-(4-isobutylphenyl)-propiopic acid

Dosage and form: coated tablets

Compound:

Description:

White or off-white, round, biconvex film-coated tablets with Nurofen printed in black on one side of the tablet.

Pharmacotherapeutic group: non-steroidal anti-inflammatory drug (NSAID).

ATC code: M01AE01

Pharmachologic effect:

Non-steroidal anti-inflammatory drug (NSAID). It has a directed action against pain, has antipyretic and anti-inflammatory properties. The mechanism of action of ibuprofen is due to the inhibition of the synthesis of prostaglandins mediators of pain, inflammation and hyperthermic reaction.

Pharmacokinetics:

Absorption is high, the connection with plasma proteins is 90%. It slowly penetrates into the joint cavity, lingers in the synovial tissue, creating higher concentrations in it than in plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver. It is excreted by the kidneys (in an unchanged form, not more than 1%) and, to a lesser extent, with bile. The half-life is 2 hours.

Indications for use:

Nurofen is used for headache and toothache, migraine, painful menstruation, neuralgia, back pain, muscle and rheumatic pain; as well as in a feverish state with influenza and colds.

Contraindications:

■ erosive and ulcerative lesions of the gastrointestinal tract and in the acute phase, including peptic ulcer of the stomach and 12 duodenal ulcer in the acute stage, ulcerative colitis, peptic ulcer, Crohn's disease;
■ heart failure;
■ severe course of arterial hypertension;
■ hypersensitivity to ibuprofen or to the components of the drug;
■ complete or incomplete syndrome of acetylsalicylic acid intolerance (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
■ diseases of the optic nerve; color vision disorder, amblyopia, scotoma;
■ deficiency of glucose-6-phosphate dehydrogenase, hemophilia and other blood clotting disorders, hemorrhagic diathesis, hypocoagulation states;
■ pregnancy III trimester, lactation period;
■ severe liver dysfunction;
■ severe renal failure (creatipip clearance less than 30 ml/min);
■ hearing loss, pathology of the vestibular apparatus;
■ period after coronary artery bypass grafting;
■ gastrointestinal bleeding and intracranial hemorrhage;
■ hemophilia and other blood clotting disorders, hemorrhagic diathesis;
■ children under 6 years of age.

Carefully: old age, ischemic heart disease, cerebrovascular disease, dyslipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, long-term use of HDL , severe somatic diseases, simultaneous administration of oral corticosteroids (including prediizolone), anticoagulants (including warfarin, clopidogrel, acetylsalicylic acid), intake of selective serotonin reuptake inhibitors, diseases while taking the drug in patients with gastric ulcer and 12 duodenal ulcer in history, with gastritis, enteritis, colitis, with anamnestic information about bleeding from the gastrointestinal tract; in the presence of concomitant diseases of the liver and / or kidneys; with cirrhosis of the liver with portal hypertension, nephrotic syndrome, chronic heart failure; arterial hypertension; with blood diseases of unclear etiology (leukopenia and anemia); with bronchial asthma, with hyperbilirubinemia; pregnancy ( I, II trimesters); age under 12 years old.

Method of application and dose:

Nurofen is prescribed for adults and children over 12 years old by mouth, after meals in tablets of 200 mg 3-4 times a day. The tablets should be taken with water.

To achieve a rapid therapeutic effect in adults, the dose may be increased to 400 mg (2 tablets) 3 times a day.

Side effects:

When using Nurofen within 2-3 days, side effects are practically not observed. In case of prolonged use, the following side effects may occur:

From the gastrointestinal tract: nausea, vomiting, heartburn, anorexia, pain and discomfort in the epigastrium, diarrhea, flatulence, erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding), abdominal pain, irritation, dryness of the oral mucosa or pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, constipation, hepatitis.

From the nervous system: headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations, rarely aseptic meningitis (more often in patients with autoimmune diseases).

From the side of the cardiovascular system: heart failure, increased blood pressure (BP), tachycardia.

From the urinary system: nephrotic syndrome (edema), acute renal failure, allergic nephritis, polyuria, cystitis.

From the side of the hematopoietic organ: anemia (including hemolytic, aplastic), thrombocytoemia and thrombocytopenic purpura, agrapulocytosis, leukopenia.

From the sense organs: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic genesis), scotoma.

Allergic reactions: skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosiiophilia, allergic rhinitis.

From the respiratory system: bronchospasm, shortness of breath.

Others: increased sweating.

With prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract , bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision impairment, scotoma, amblyopia).

If side effects occur, stop taking the drug and consult a doctor.

Overdose:

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, lowering blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within an hour after ingestion), activated charcoal, alkaline drink, forced diuresis, symptomatic therapy.

Interaction with other drugs:

Simultaneous administration of Nurofen tablets with acetylsalicylic acid (ASA) and other NSAIDs is not recommended. With the simultaneous appointment of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (ASA) (it is possible to increase the incidence of acute coronary insufficiency in patients , receiving low doses of acetylsalicylic acid (ASA) as an antiplatelet agent after starting ibuprofen). 1 When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokipase), the risk of bleeding increases at the same time. Cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin, increase the purity of the development of hypoprothrombinemia. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, fepilbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions. Microsomal oxidation inhibitors - reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiaggregants, fibrinolytics. Enhances the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs, sulfonylurea and insulin derivatives. Antacids and cholestyramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Special instructions:

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodeposcopy, complete blood count (determination of hemoglobin ), stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. Freemen must refrain from all types of activities that require increased attention, quick mental and motor reactions. During the treatment period, you should refrain from drinking alcohol.

Release form:

Coated tablets, 200 mg

6 or 12 tablets per blister (PVC/PVDC/aluminium).

One blister (6 or 12 tablets each), two blisters (but 6 or 12 tablets), 3 blisters (12 tablets each) or 8 blisters (12 tablets each), together with instructions for use, are placed in a cardboard box or plastic container.

Storage conditions:

At a temperature not higher than + 25 ° C, out of the reach of children! In a dry place.

Best before date:

Do not use an expired product.

Vacation from pharmacies:

Without recipe.

Manufacturer:

Reckitt Benckiser Healthcare International Ltd,
Thein Road, Nottingham, NG90 2DB. Great Britain,

Representative in Russia / address for filing a claim:

Reckitt Benckiser Healthcare LLC
Russia, 115114, Moscow, Kozhevnicheskaya st., 14

Nurofen for children (tablets) (Nurofen for children)

Compound

1 film-coated tablet of Nurofen for children contains:
Ibuprofen - 200 mg;
Additional ingredients including sucrose.

pharmachologic effect

Nurofen for children is an anti-inflammatory, antipyretic and analgesic. Nurofen for children in the form of tablets contains the active ingredient ibuprofen, a non-narcotic analgesic with a pronounced anti-inflammatory effect. Ibuprofen is a non-selective cyclooxygenase inhibitor that inhibits the synthesis of prostaglandins and thromboxane A from arachidonic acid. Due to a decrease in the level of prostaglandins in the nervous tissue, when taking ibuprofen, there is a decrease in the generation and conduction of a pain impulse.
The anti-inflammatory effect of the drug Nurofen for children is realized by reducing the level of prostaglandins in the focus of inflammation, and the antipyretic effect is due to a decrease in the level of prostaglandins in the thermoregulation center in the hypothalamus.

Ibuprofen reduces platelet aggregation by reducing the level of thromboxane A.
When taken orally, ibuprofen is well absorbed into the systemic circulation and reaches peak plasma concentrations within 1-2 hours. About 90% of ibuprofen binds to plasma proteins. The active component of the drug Nurofen for children penetrates into the synovial fluid (concentrations in synovial fluid exceed those in plasma).
Ibuprofen is metabolized in the liver to inactive derivatives. It is excreted mainly by the kidneys in the form of metabolites. The half-life of the active component of the drug Nurofen for children reaches 2 hours.

Indications for use

Nurofen for children in the form of tablets is used as a symptomatic remedy for pain in children over 6 years of age and adults (including toothache, headache and joint pain, migraine, algomenorrhea).
Nurofen for children in the form of tablets can also be prescribed as an antipyretic for infectious diseases.

Mode of application

Nurofen for children in the form of tablets is intended for oral use. It is recommended to take the drug after meals with plenty of drinking water. Nurofen in the form of tablets is used to treat adults and children over 12 years of age. The duration of therapy and the dose of ibuprofen is determined by the attending physician.
Children over 12 years of age and adults are usually prescribed 1 tablet of Nurofen for children no more than 4 times a day.
With severe pain in adults, the dose may be increased to 400 mg ibuprofen.
Children from 6 to 12 years old are prescribed to take 1 tablet of Nurofen for children no more than 4 times a day under the supervision of a physician.

The maximum recommended daily dose of ibuprofen for children over 6 years of age is 800 mg, for adults - 1200 mg.
The recommended interval between single doses is at least 6 hours.
If within 3 days there is no improvement in the clinical picture, you should contact your doctor.
With prolonged (more than 3 days) taking the drug Nurofen for children in the form of tablets, the peripheral blood picture, as well as the function of the kidneys and liver, should be monitored. It should be borne in mind that with prolonged use, the risk of side effects increases, including from the digestive tract.

Side effects

With short-term (2-3 days) use of the drug Nurofen for children in the form of tablets, there was practically no development of undesirable effects. Mostly when taking high doses of ibuprofen or long-term use of the drug in patients, the following undesirable effects were noted:

From the digestive tract: vomiting, heartburn, stool disorders, loss of appetite, pain in the epigastric region, flatulence. In rare cases, the development of ulcerative lesions of the digestive tract, pain in the abdominal region, dryness, irritation and ulceration of the oral mucosa, hepatitis and pancreatitis, as well as gastrointestinal bleeding has been noted.
From the nervous system: depression, headache, insomnia, dizziness, drowsiness, agitation or fatigue, confusion. In rare cases, the development of hallucinations and aseptic meningitis was noted (mainly in patients with autoimmune diseases).

From the side of blood vessels, heart and blood system: tachycardia, arterial hypertension, heart failure, anemia, thrombocytopenia, agranulocytosis, thrombocytopenic purpura, leukopenia.
From the urinary system: cystitis, nephrotic syndrome, allergic nephritis, renal failure, polyuria.
From the senses: ringing and noise in the ears, decreased hearing and visual acuity, reversible toxic optic neuritis, diplopia, irritation and dry eyes, scotoma, conjunctival edema.
Allergic reactions: urticaria, Stevens-Johnson syndrome, Lyell's syndrome, allergic rhinitis, anaphylactic shock, angioedema, bronchospasm.
Others: increased sweating.

With the development of side effects, including those not listed in the instructions, you should consult a doctor.

Contraindications

Film-coated tablets Nurofen for children are not prescribed to patients with personal intolerance to ibuprofen and other non-narcotic analgesics (including patients with a history of the "aspirin triad").
Nurofen for children is not prescribed for erosive and ulcerative lesions of the digestive tract in the acute period, for cardiac, renal and hepatic insufficiency, as well as for patients who have undergone coronary artery bypass grafting, and for patients with bleeding (including intracranial hemorrhages and gastrointestinal bleeding).
Ibuprofen is not used in patients with severe arterial hypertension, color perception disorders, optic nerve diseases, scotoma and amblyopia, as well as hearing loss and pathologies of the vestibular apparatus.

Nurofen for children is not used in patients suffering from glucose-6-phosphate dehydrogenase deficiency, clotting disorders (including hemophilia, hypocoagulation and hemorrhagic diathesis).
In pediatric practice, the drug Nurofen for children in the form of film-coated tablets is used only for the treatment of children over 6 years old; for children under 12 years of age, Nurofen for children in the form of film-coated tablets is prescribed with caution.
Nurofen for children in the form of tablets should be used with caution in patients with heart and vascular diseases (including coronary heart disease, peripheral and cerebral vascular diseases, chronic heart failure, arterial hypertension), hematopoietic disorders, diabetes mellitus, dyslipidemia, severe somatic diseases, as well as a history of peptic ulcer or gastrointestinal bleeding.

With caution, ibuprofen is used in smokers and people who often drink alcohol or receive therapy with systemic glucocorticosteroids, anticoagulants and serotonin reuptake inhibitors, as well as in patients with kidney and liver diseases (including nephrotic syndrome and liver cirrhosis), hyperbilirubinemia, bronchial asthma.
Care should be taken when prescribing Nurofen for children to patients suffering from diseases of the digestive tract, including gastritis, colitis and enteritis.
In addition, ibuprofen is used with caution in the elderly.

Pregnancy

Nurofen for children should only be used in pregnant women if safer treatments have failed. Ibuprofen during pregnancy should be used in minimal doses, for a short period and under the mandatory supervision of a physician.
Ibuprofen should be avoided during the first and second trimesters of pregnancy.

drug interaction

Nurofen for children should not be administered simultaneously with other drugs of the group of non-steroidal anti-inflammatory drugs, as well as acetylsalicylic acid.
There is an increased risk of bleeding with the combined use of ibuprofen with thrombolytic and anticoagulant drugs.
Cefamandol, cefotetan, cefoperazone, plicamycin and valproic acid, when used simultaneously with ibuprofen, increase the risk of developing hypoprothrombinemia.
Gold preparations and cyclosporins increase the nephrotoxicity of ibuprofen.
Nurofen for children increases plasma concentrations and hepatotoxicity of cyclosporine.
Drugs that inhibit tubular secretion increase plasma concentrations of ibuprofen.
Microsomal oxidation inducers increase the synthesis of active ibuprofen metabolites and the risk of hepatotoxicity, and microsomal oxidation inhibitors reduce the risk of ibuprofen hepatotoxicity.

Ibuprofen reduces the effectiveness of vasodilators, furosemide and hydrochlorothiazide, as well as uricosuric agents.
Nurofen for children potentiates the effects of antiplatelet agents, anticoagulants, fibrinolytic agents, insulin and oral hypoglycemic drugs, sulfonylurea derivatives.
Ibuprofen increases the risk of developing adverse effects of corticosteroids, estrogens and ethyl alcohol, and also increases plasma concentrations and toxicity of lithium, methotrexate and digoxin.
Antacids and cholestyramine reduce the intestinal absorption of ibuprofen.
Caffeine potentiates the analgesic effect of ibuprofen.

Overdose

When using excessive doses of ibuprofen, patients may develop drowsiness or agitation, headache, pain in the epigastric region, vomiting, tinnitus, dizziness and depression. With a further increase in the dose of the drug Nurofen for children, the development of metabolic acidosis, acute renal failure, arterial hypotension, arrhythmias, respiratory arrest and coma is possible.
The specific antidote is unknown. In case of overdose, gastric lavage is carried out, enterosorbent agents and alkaline drink are prescribed. To reduce plasma concentrations of ibuprofen, forced diuresis is performed. If necessary, prescribe supportive and symptomatic therapy.

Release form

Coated tablets, Nurofen for children, 6 or 12 pieces in blister packs, in a carton pack of 6, 12, 24, 36 or 96 tablets. Attention!
Description of the drug Nurofen for children (tablets)" on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult a doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

Active ingredient - ibuprofen 200 mg in 1 tablet

Release form

Tablets for oral administration, 8 pieces per pack.

pharmachologic effect

Non-steroidal anti-inflammatory drug. It has analgesic, antipyretic and anti-inflammatory effects.

The mechanism of action of ibuprofen, a propionic acid derivative, is due to the inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect is most pronounced in inflammatory pain. The action of the drug lasts up to 8 hours.

Indication for use

headache;
migraine;
toothache;
neuralgia;
myalgia;
back pain;
rheumatic pains;
pain in the joints;
algomenorrhea;
fever with influenza and SARS.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Methods of application and doses

The drug is taken orally. The tablets should be taken with water. Patients with hypersensitivity of the stomach are recommended to take the drug during meals.

The drug is intended for short-term use only.

Adults and children over 12 years of age are prescribed 1 tab. (200 mg) up to 3-4 times / day. To achieve a faster therapeutic effect in adults, the dose can be increased to 2 tab. (400 mg) up to 3 times / day.

Children aged 6 to 12 years are prescribed 1 tab. (200 mg) up to 3-4 times / day; the drug can be prescribed only to children weighing more than 20 kg.

The interval between taking the tablets should be at least 6 hours.

The maximum daily dose for adults is 1200 mg (6 tablets). The maximum daily dose for children aged 6 to 18 years is 800 mg (4 tablets).

If, when using the drug for 2-3 days, the symptoms persist or intensify, it is necessary to stop treatment and consult a doctor.

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including history);
erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis) or ulcer bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcer bleeding);
bleeding or perforation of a gastrointestinal ulcer in history, provoked by the use of NSAIDs;
severe liver failure or active liver disease;
severe renal failure (CK<30 мл/мин);
confirmed hyperkalemia;
decompensated heart failure;
the period after coronary artery bypass grafting;
cerebrovascular or other bleeding;
hemophilia and other blood clotting disorders (including hypocoagulation);
hemorrhagic diathesis;
III trimester of pregnancy;
children's age up to 6 years;
fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency;
hypersensitivity to ibuprofen and other components of the drug.

special instructions

It is recommended to take the drug in the shortest possible course and in the minimum effective dose necessary to eliminate symptoms. If you need to use the drug for more than 10 days, you should consult a doctor.

Does not contain dyes.

Storage conditions

The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25 ° C.