Calcium chloride - official instructions for use. Calcium chloride - what is it? How is calcium chloride used for allergies

active substance: 1 ml of the drug contains calcium chloride 100 mg;

excipient: water for injections.

Dosage form

Injection.

Pharmacotherapeutic group

Blood substitutes and perfusion solutions. electrolyte solutions. ATC code B05X A07.

Indications

Cases of hypocalcemia requiring a rapid increase in the concentration of calcium ions in the blood plasma (tetany with functional parathyroid insufficiency, tetany with vitamin D deficiency, hypocalcemia with exchange transfusion and infusion of citrate blood, alkalosis). As part of complex therapy for acute lead colic. Cases of magnesium intoxication arising from an overdose of magnesium. Hyperkalemia registered on the ECG as a violation of cardiac function.

Contraindications

Hypersensitivity to the components of the drug. Hypercalcemia. Atherosclerosis with arterial occlusion. Tendency to thrombosis. Ventricular fibrillation. Children's age up to 1 year.

Dosage and administration

Calcium chloride is prescribed intravenously in a stream (very slowly) and intravenously drip (slowly).

Adults.

Intravenous administration by jet: 5 ml of a 10% solution is injected at a rate of 1 ml / min.

Intravenous drip administration: 5-10 ml of a 10% solution of the drug is diluted in 100-200 ml of a 0.9% sodium chloride solution or 5% glucose solution; administered at a rate of 6-8 drops / min.

Exchange transfusion and citrated blood transfusion: Adults and children: 30 mg (0.3 ml) for every 100 ml of blood.

Tetany in adults: 10 ml of a 10% solution (1 g) for 10-30 minutes, if necessary, repeat after 6 hours.

Children.

Hypocalcemia: administered slowly, at a rate of 0.5 ml / min, at a dose of 10-20 mg / kg body weight (0.1-0.2 ml / kg body weight), if necessary, repeat every 4-6 hours.

Tetany: 10 mg/kg body weight (0.1 ml/kg body weight) over 5-10 minutes, repeated if necessary after 6 hours or continued as an infusion. The maximum daily dose for children (regardless of age) is 10 ml (1000 mg).

Adverse reactions

Hypersensitivity reactions: a feeling of heat, first in the mouth, and then throughout the body; flushing of the skin of the face;

cardiovascular disorders: moderate and short-term decrease in blood pressure; bradycardia; rapid intravenous administration can cause vasodilation, ventricular fibrillation;

changes in the skin and its derivatives: soft tissue calcification;

general violations: chalky taste, hypercalcemia;

local reactions: tissue necrosis, pain and hyperemia at the injection site.

Overdose

Overdose can cause depression of cardiac activity, the appearance of tachycardia and a sharp decrease in blood pressure, as well as acute hypercalcemic syndrome: anorexia, nausea, vomiting, constipation, abdominal pain; mental disorders, drowsiness, muscle weakness, polyuria, polydipsia, nephrolithiasis, in severe cases - cardiac arrhythmias, coma.

Treatment. Stop administering the drug. Therapy is symptomatic.

Use during pregnancy or lactation

Use during pregnancy is possible only if the benefit to the mother outweighs the potential risk to the fetus.

It is possible to use the drug during breastfeeding.

Children

Application to children is possible from the 1st year.

Application features

The injection needs to be wired through a thin needle into a large vein to minimize the damaging effect of the drug on the vessel wall. Calcium chloride should not be administered subcutaneously or intramuscularly due to its strong irritant and necrotic effect. In the case of such an injection, it is necessary to suck it as far as possible with a syringe and inject 10 ml of sodium sulfate, injection solution 25%, or 5-10 ml of magnesium sulfate, injection solution 25% into the injection site. To eliminate the resorptive effect, diphenhydramine is prescribed, with hypercalcemia - EDTA.

With intravenous administration of the drug, the usual reaction to it appears - a feeling of heat in the mouth, and then throughout the body.

When using it is necessary to carefully monitor the level of calcium in the blood. Caution should be used in patients with kidney disease, nephrolithiasis or diseases accompanied by hypercalcemia (in particular with malignant neoplasms and sarcoidosis) and cardiovascular diseases.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms

During the period of treatment with the drug, driving and working with dangerous mechanisms are contraindicated.

Interaction with other drugs and other types of interactions. Do not use with thiazide diuretics or vitamin D due to increased risk of hypercalcemia. Do not administer calcium chloride and ceftriaxone at the same time. Calcium chloride reduces the cardiotonic effects of dobutamine. Calcium salts reduce the absorption of drugs such as bisphosphonates, fluorides, and some fluoroquinolones. With simultaneous use reduces the effect of calcium channel blockers, with quinidine - it is possible to slow down intraventricular conduction and increase the toxicity of quinidine. During treatment with cardiac glycosides, parenteral use of calcium chloride is not recommended due to increased cardiotoxicity.

Pharmacological properties

Pharmacodynamics. The drug eliminates the deficiency of calcium ions. Calcium ions take part in the transmission of nerve impulses, contraction of smooth and skeletal muscles, in the functional activity of the myocardium, blood coagulation; necessary for the formation of bone tissue, the functioning of other systems and organs. The concentration of calcium ions in the blood decreases due to many pathological processes, severe hypocalcemia contributes to the appearance of tetany. Calcium chloride, in addition to eliminating hypocalcemia, reduces vascular permeability, exhibits a hemostatic effect.

Pharmacokinetics. In the blood, calcium is found in compounds and in an ionized state. Physiological activity is inherent in ionized calcium. deposited in bone tissue. Excreted from the body with urine, but mainly with feces.

Basic physical and chemical properties

clear colorless liquid.

Incompatibility

Not compatible with tetracyclines. Do not administer calcium chloride and ceftriaxone at the same time.

Best before date

Storage conditions

Keep out of the reach of children at a temperature not exceeding 25 ºС.

Package

5 ml or 10 ml in an ampoule; 5 ampoules in a blister pack; 2 blisters in a pack; 5 ml or 10 ml in an ampoule; 10 ampoules in a box.

Compound: calcium chloride, water for injection.
Package: bottle, 100 ml.
Storage conditions: at t from 0 0С to 25 0С.
Best before date: 2 years.
Indications: in order to increase the calcium content in the blood, as an anti-inflammatory, hemostatic and desensitizing agent, to normalize the activity of the sympathetic nervous system.
Mode of application: injection.

INSTRUCTIONS for the use of calcium chloride 10% solution for injection in veterinary medicine

1. GENERAL

1.1. Calcium chloride 10% injection.
1.2. It is a clear, colorless, sterile liquid.
1.3. The drug is produced packaged in 100, 200, 250, 400, 450, 500 ml in sterile vials and bottles made of neutral glass, sealed with rubber stoppers and rolled in aluminum caps, or 10 and 20 ml in sealed ampoules.
Each package is labeled with the name of the manufacturer, its address and trademark, the name of the drug, the content of the active substance, the nominal volume, the batch number, the date of manufacture, the expiration date, storage conditions, the designation of specifications, the inscriptions "Sterile", "For animals" and provide the Instructions for Use.
Other types of packaging are allowed, agreed in the prescribed manner.
1.4. The drug is stored in the manufacturer's packaging, in a dry, dark place at a temperature of 0 0C to 25 0C.
The shelf life of the drug, subject to storage conditions - in vials and bottles - 2 years, in ampoules - 10 years from the date of manufacture.

2. PHARMACOLOGICAL PROPERTIES

2.1. calcium chloride plays an important role in the life of the organism. It activates the reticuloendothelial system and the phagocytic function of leukocytes, increases the tone of the sympathetic nervous system, increases the release of adrenaline, reduces vascular permeability, exhibits an anti-inflammatory effect and prevents the development of edema.
Calcium ions are necessary for the implementation of the processes of transmission of nerve impulses, contraction of skeletal muscles and heart muscles, bone formation and blood clotting.

3. ORDER OF APPLICATION OF THE DRUG

3.1. Calcium chloride 10% injection is prescribed to increase the calcium content in the blood, as an anti-inflammatory, hemostatic and desensitizing agent, to normalize the activity of the sympathetic nervous system in the following pathological conditions:
- pneumonia, pleurisy, toxic liver damage, parenchymal hepatitis, nephritis, radiation sickness, pulmonary edema, larynx, edematous disease of piglets;
- allergic diseases (serum sickness, equine hemorrhagic disease, chronic urticaria in horses and cattle), allergic complications associated with the use of drugs;
- bleeding (uterine, gastrointestinal, pulmonary, postoperative) to reduce vascular permeability in hemorrhagic, inflammatory and exudative processes;
- skin diseases (itching, eczema, dermatoses, etc.);
- in obstetric and gynecological practice to stimulate labor activity, accelerate the separation of the delayed placenta, with endometritis, puerperal paresis, postpartum hematuria in cows;
- hypotension and atony of the proventriculus, hemorrhagic gastroenteritis, tetany of young animals;
- with vegetative neurosis, eclampsia in dogs, acetonemia in cows, paralytic myoglobinuria in horses;
- in case of poisoning with magnesium salts, oxalic acid, soluble salts of oxalic and fluoric acids, sodium chloride.
3.2. Calcium chloride solution 10% for injection is administered intravenously (slowly!) In the following single doses (depending on the weight of the animal):

4. PRECAUTIONS

When working with the drug, you should follow the general rules of personal hygiene and safety precautions provided for when working with injectable drugs for animals.

The manual was developed by CJSC NPP "Agrofarm" (Voronezh) and CJSC "Mosagrogen" (Moscow).
With the approval of this instruction, consider the instruction on the use of a 10% calcium chloride solution for injection No. 13-5-2 / 318 dated 05/26/95 as invalid on the territory of the Russian Federation.
The drug was recommended for registration in the Russian Federation at an extended meeting of methodological commissions for the control and standardization of vitamin preparations, feed and feed additives, chemotherapeutic and other drugs used in animal husbandry and veterinary medicine, June 3, 2003 (minutes No. 1).
Number PVR-2-1.9/00126

Tradename: calcium chloride

International non-proprietary name:

Compound:

Description: colorless transparent liquid.

Pharmacotherapeutic group:

pharmachologic effect
Calcium preparation, compensates for the deficiency of calcium, necessary for the implementation of the process of transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone tissue formation, blood clotting. It reduces the permeability of cells and the vascular wall, prevents the development of inflammatory reactions, increases the body's resistance to infections and can significantly enhance phagocytosis (phagocytosis, which decreases after taking sodium chloride, increases after taking calcium supplements). When administered intravenously, it stimulates the sympathetic division of the autonomic nervous system, enhances the secretion of epinephrine by the adrenal glands, and has a moderate diuretic effect.

Pharmacokinetics
In plasma, about 45% is in complex with proteins. About 20% is excreted by the kidneys, the rest (80%) are removed with the contents of the intestine.

Indications for use
Bleeding of various etiology and localization (pulmonary, gastrointestinal, nasal, uterine, etc.); allergic diseases (serum sickness, urticaria, febrile syndrome, itching, Quincke's edema); dystrophic nutritional edema, spasmophilia; hypoparathyroidism, hypocalcemia, increased vascular permeability (hemorrhagic vasculitis, radiation sickness), weakness of labor activity, poisoning with magnesium salts, oxalic and fluoric acids: paroxysmal myoplegia (hyperkalemic form).

Contraindications
Hypersensitivity, hypercalcemia. atherosclerosis. tendency to thrombosis.

Dosage and administration
Intravenously slowly (6-8 drops / min), 5-15 ml of a 10% solution, diluted before administration in 100-200 ml of a 0.9% NaCl solution or 5% dextrose solution.

Side effect
With intravenous administration - a feeling of heat, flushing of the skin of the face, bradycardia, with rapid administration - ventricular fibrillation of the heart.
Local reactions (with intravenous administration) - pain and hyperemia along the vein.

Interaction with other drugs
When combined with thiazide diuretics, it can increase hypercalcemia, reduce the effect of calcitonin in hypercalcemia, and reduce the bioavailability of phenytoin.

special instructions
Do not administer subcutaneously or intramuscularly, tissue necrosis is possible (high concentrations of calcium chloride, starting from 5%, cause severe irritation of the vascular wall).
With intravenous administration of calcium chloride, a sensation of heat appears first in the oral cavity, and then throughout the body (previously used to determine the rate of blood flow - the time between the moment it is injected into a vein and the appearance of a sensation of heat).

Release form
Solution for intravenous administration of 100 mg ml in ampoules of 5, 10 ml. 10 ampoules, together with instructions for use, are placed in a cardboard box. 5 ampoules are placed in a blister pack. 2 blister packs, together with instructions for use, are placed in a cardboard pack.
An ampoule knife or a scarifier is put into each pack. When packing ampoules with a break point or ring, an ampoule knife or a scarifier is not included.

Best before date
5 years. Do not use after the expiry date stated on the packaging.

Storage conditions
In a dry, dark place at a temperature of 18 to 25 ° C. Keep out of the reach of children.

Terms of dispensing from pharmacies
On prescription.

Manufacturer:

Consumer claims should be sent to:
FSUE "Armavir Biological Factory"
352212 Krasnodar Territory, Novokubansky District, Progress Settlement, st. Mechnikov, 11.

COMPOSITION AND FORM OF RELEASE

The drug is a clear colorless liquid containing calcium chloride water for injection. Packed in glass bottles of 100 ml.

PHARMACOLOGICAL PROPERTIES

Calcium chloride plays an important role in the life of the body. It activates the reticuloendothelial system and the phagocytic function of leukocytes, increases the tone of sympathetic innervation, increases the release of adrenaline, and accelerates the production of many enzymes. Calcium ions are necessary for the contraction of skeletal muscles and heart muscles, bone formation, blood clotting. They seal the walls of blood vessels, thereby exhibiting an anti-inflammatory effect and prevent the development of edema. Calcium is involved in the process of blood clotting, promotes the conversion of prothrombin to thrombin.

INDICATIONS

As an anti-inflammatory agent for pneumonia, pleurisy, peritonitis, toxic liver damage, parenchymal hepatitis, nephritis; with radiation sickness, toxic pulmonary edema, hypertension and pulmonary edema, laryngeal edema, edematous disease of piglets. As a hemostatic agent for nasal, gastrointestinal, pulmonary, uterine and postoperative bleeding. As a desensitizing agent for allergic diseases (asthma, serum sickness, pruritus, horse hemorrhagic disease, chronic urticaria in horses and cattle) and allergic complications after the use of drugs. As a calming and normalizing agent for the nervous system in autonomic neurosis, eclampsia in dogs, acetonemia in cows, paralytic myoglobinuria in horses. In obstetric and gynecological practice with endometritis, metritis, to stimulate labor activity, accelerate the separation of the delayed placenta in animals, prevent abortion, with maternity paresis, postpartum hematuria in cows. The drug is used for hypotension and atony of the proventriculus, hemorrhagic gastroenteritis, tetany of young animals to increase the level of calcium in the blood and relieve seizures, and is also prescribed as an antidote for poisoning with magnesium salts, oxalic acid, soluble salts of fluoric and oxalic acids, table salt. The drug is part of anti-shock, blood-replacement and nutritional fluids and solutions.

DOSES AND METHOD OF APPLICATION

The drug is administered intravenously, slowly. If, with an unsuccessful injection, part of it got subcutaneously, it is necessary to inject a large amount of isotonic sodium chloride solution 0.9% around the injection site to prevent tissue necrosis. Maximum single doses (in ml per animal): Cattle - 150-400 ml. Horses - 100-300 ml. Small cattle - 10-30 ml. Pigs - 10-20 ml. Dogs - 5-15 ml. The volume of the dose and the timing of application depend on the weight of the animal and the course of the disease.

CONTRAINDICATIONS

Do not administer subcutaneously or intramuscularly, as it causes severe irritation and tissue necrosis. Calcium chloride is contraindicated in patients with a tendency to thrombosis, an increased content of calcium in the blood.

SPECIAL INSTRUCTIONS

Livestock products after the application of calcium chloride solution can be used without restrictions.

STORAGE CONDITIONS

In the manufacturer's container in a dry, dark place at a temperature of 0 to 25 °C. Shelf life - 10 years from the date of manufacture.

Instructions for use Calcium chloride 10% solution for injection as
anti-inflammatory, hemostatic and desensitizing agent for animals
(Organization-developer: Mosagrogen CJSC)

I. General information
Calcium chloride 10% injection solution (Calcii chloridi 10% solutio pro injectionibus).
International non-proprietary name: calcium chloride.

Dosage form: solution for injections.
1 ml of the drug contains 100 mg of calcium chloride as an active substance, as well as an auxiliary substance - water for injection up to 1 ml.
The drug is a colorless transparent liquid.

Calcium chloride 10% is produced packaged in 100 ml glass bottles of appropriate capacity, sealed with rubber stoppers, reinforced with aluminum caps.

Store the drug in a closed manufacturer's packaging in a dry place, protected from direct sunlight, away from food and feed, at a temperature of 0°C to 25°C.
The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of manufacture. After opening the vial, unused residues of the drug are not subject to storage. It is forbidden to use the drug after the expiration date.
CaCl solution for injection should be kept out of the reach of children.
Disposal of the unused drug is carried out in accordance with the requirements of the law.

II. Pharmacological properties
Pharmacotherapeutic group: drugs that affect metabolism.
calcium chloride in the body of animals it activates the reticuloendothelial system and the phagocytic function of leukocytes, increases the tone of the sympathetic nervous system, increases the release of adrenaline, reduces the permeability of blood vessels, exhibits an anti-inflammatory effect and prevents the development of edema.
Calcium ions are necessary for the implementation of the processes of transmission of nerve impulses, contraction of skeletal muscles and heart muscles, bone formation, blood clotting. After administration, the drug is rapidly distributed in the organs and tissues of the animal.

According to the degree of impact on the body, Calcium chloride 10% injection according to GOST 12.1.007-76 belongs to low-hazard substances (hazard class 4).

III. Application procedure
Calcium chloride 10% is prescribed to animals in order to increase the calcium content in the blood, as an anti-inflammatory, hemostatic and desensitizing agent, to normalize the activity of the sympathetic nervous system in the following pathological conditions:

• pneumonia, pleurisy, peritonitis, toxic liver damage, parenchymal hepatitis, nephritis, radiation sickness, pulmonary edema, larynx, edematous disease of piglets;
• bleeding (uterine, gastrointestinal, pulmonary, postoperative) to reduce vascular permeability in hemorrhagic, inflammatory and exudative processes;
• allergic diseases, allergic complications associated with the use of drugs;
• in obstetric and gynecological practice with endometritis, metritis, to stimulate labor activity, accelerate the separation of the delayed placenta in animals, prevent abortion, with maternity paresis, postpartum hematuria in cows;
• with hypotension and atony of the proventriculus, hemorrhagic gastroenteritis, tetany of young animals;
• with vegetative neurosis, postpartum eclampsia in dogs, acetonemia in cows, paralytic myoglobinuria in horses;
• in case of poisoning with magnesium salts, oxalic acid and its salts, sodium chloride.

A contraindication to the use of calcium chloride solution is an increased content of calcium in the blood (hypercalcemia) and a tendency to thrombosis.

Calcium chloride 10% solution is administered to animals intravenously slowly in the following single doses (depending on the weight of the animal):

Doses and terms of application depend on the weight of the animal and the course of the disease and are determined by the veterinarian.

Overdose symptoms - hypercalcemia (thirst, vomiting, constipation). Overdose can cause depression of cardiac activity and the appearance of tachycardia.

Features of the action of the drug during its first use and cancellation were not revealed.
Special measures for skipping one or more doses of the drug are not required. Do not give a double dose to make up for a missed dose.

Do not inject calcium chloride under the skin or into muscles, due to the strong irritating and necrotic action. In case of accidental ingestion of the drug under the skin to prevent tissue necrosis, around the injection site, it is necessary to introduce a large amount of isotonic sodium chloride solution 0.9%.
With intravenous administration, the drug can cause bradycardia, and with rapid administration, fibrillation.

Do not mix Calcium chloride 10% solution in the same syringe with other drugs.
The use of Calcium chloride 10% does not exclude the use of other drugs.
Calcium chloride is incompatible with tetracycline preparations.

Animal products during and after the application of Calcium chloride 10% are used without restrictions.

IV. Measures of personal prevention
When working with calcium chloride, you should follow the general rules of personal hygiene and safety precautions provided for when working with drugs. At the end of work, hands should be washed with warm water and soap.
In case of accidental contact of the drug with the skin or mucous membranes of the eye, they must be washed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with the drug. In case of allergic reactions or in case of accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for using the drug or a label with you).

Empty drug bottles must not be used for domestic purposes, they must be disposed of with household waste.

Organization-manufacturer: CJSC "Mosagrogen"; 117545, Moscow, 1st Dorozhny proezd, 1.

With the approval of this Instruction, the Instructions for the use of Calcium chloride 10% solution for injection approved by the Rosselkhoznadzor on 01.12.2008 become invalid.