What is the medicine "Piracetam"? Reviews of consumers, description of the composition and properties of the drug. Why is Piracetam prescribed and what to expect from the drug in different cases? Dosage and administration

Piracetam is pharmaceutical agent belonging to a group of medicines used to improve cerebral circulation(nootropics). The origin of the drug is synthetic.

Due to the mechanism of action of the drug, it is often prescribed by doctors for the treatment various diseases in such branches of medicine as psychiatry, narcology and neurology. Also, the drug is used to restore patients after a stroke.

The medicine Piracetam in tablets is very popular among students of higher educational institutions who acquire it in cases where it is required to stimulate mental activity and the ability to memorize, because the drug helps to improve concentration.

In what cases is the drug prescribed?

The action of the drug Piraceram is based on enhancing the work of cells nervous system on the release of dopamine, an increase in the concentration of norepinephrine, acetylcholine and activation of cholinergic receptors. It contributes to the activation of glucose metabolism, as well as the normalization of the regenar circulation of those parts of the brain that have suffered after a stroke.

Due to the focus of the drug on the nervous and circulatory system, it is prescribed in order to significantly enhance the metabolic processes in the brain. The drug can be used to improve redox reactions in the body, stimulate energy capabilities nerve cells and fabrics.

The drug does not contribute to the appearance of a sedative, hypnotic, slowing effect, after taking it, you can drive a car or do work that requires concentration. Able to enhance the conductivity of nerve cells. Piracetam can be used after strokes intravenously or intramuscularly as an injection of the drug.

This nooprop is prescribed to improve the state of consciousness, speech and memory, due to the cerebral focus of action. For the most correct work of the drug, it is most correct to use it before meals.

The drug is indicated for use in the treatment of a large number of diseases, it can also be taken to improve general condition nervous system. Depending on the indications, dose, desired effects and other factors, the combination of which allows the drug to be used for a long time, tablets, capsules and intravenous injections are prescribed in the following cases:


Contraindications

The drug has several contraindications, which include:


Features of admission and side effects

The drug can be used in the treatment of various diseases, depending on the nature of the pathology, the duration of treatment and the method of administration. active substance. The answer to the question "How to take Piracetam?" will depend on the severity of the patient's condition and the decision of the attending physician.


Both pills and injections are used to improve memory and concentration, depending on whether correction of the usual brain activity in better side or you need intensive recovery after an injury or stroke.

Side effects

Piracetam may cause the following side effects:


The manifestation of side effects depends on the correct administration of the drug and compliance with the dosing regimen. You need to take the medicine as directed by your doctor.

Features of use in stroke therapy

Piracetam occupies a leading position in the treatment of stroke. He does not provide toxic action in combination with other drugs that restore the activity of a brain area damaged by a stroke, it accelerates regeneration, thereby contributing to the restoration of basic neurological functions (memory, attention, speech, etc.).

The drug is used to treat acute period ischemic stroke, and after an attack.

The cost of the drug

Piracetam is a drug with a low cost, despite its effectiveness and wide range actions. It can be purchased by a patient with any income in pharmacies in Moscow and St. Petersburg.

The cost of the drug in various forms for receiving:

  • Piracetam tablets 200 mg 60 pcs. - 40 r.
  • Piracetam injection solution 20% 5 ml 10 pcs. - 55 p.
  • Piracetam tablets 400 mg 60 pcs. - 60-70 rubles.
  • Piracetam tablets 800 mg 30 pcs. — 80 r.
  • Piracetam 400 mg 60 caps. - 150 r.

Prices for a drug will depend on the brand of the pharmacy and the manufacturer of the goods, the country of the manufacturer and the mark-up of the pharmacy organization.

Before taking this drug, patients try to find out what Piracetam is prescribed for. Such a drug is very common in medical practice. It is widely used in neurology and psychiatry. Given the indications for the use of this medication, it should be in the medicine cabinet of almost every elderly person.

Piracetam - composition of the drug

Given nootropic consists of the main active ingredient and auxiliary ingredients. Depending on the form in which Piracetam is produced, the composition may vary slightly. Produce this drug in these forms:

  • capsules;
  • solution;
  • tablets.

Piracetam injections


The injection solution is available in ampoules. Each of them contains 5 ml of the drug. Piracetam is sold in packs of 10 ampoules. The injection solution is a colorless or slightly yellowish liquid. In addition to the main active component, Piracetam in ampoules also includes excipients:

  • sodium acetate;
  • acetic acid;
  • water.

Piracetam tablets

Outwardly, these are large pills of white or yellowish color. In addition to the main component of the same name, Piracetam has the following tablet composition:

  • talc;
  • stearate;
  • ethylcellulose;
  • povidone and so on.

Piracetam - indications for use


This drug is prescribed for various problems with health. Piracetam indications are extensive. In neurological practice, it is prescribed in such cases:

  • disorders of cerebral circulation;
  • pathologies leading to a violation of emotions and a decrease in intelligence;
  • vascular diseases, including hypertension;
  • brain intoxication;
  • coma;

Here's why Piracetam is prescribed in psychiatry:

  • therapy for organic lesion brain;
  • at poor tolerance neuroleptics in order to prevent the complications caused by them;
  • treatment of schizophrenia and epilepsy;
  • prescribed in complex therapy.

In narcological practice, Piracetam is used in such cases:

  • chronic alcoholism;
  • poisoning with barbiturates or alcohol;
  • drug and alcohol withdrawal;
  • delirious state.

This medication is prescribed even for children. In pediatrics, it is used for:

  • brain damage by intrauterine infections;
  • oligophrenia;
  • delayed mental or mental development.

How to take Piracetam?

All appointments must be made by a doctor. Piracetam has a special application. Tablets or capsules should be taken before or during meals. The daily rate must be divided into several doses. To prevent sleep problems, take the drug before 17.00. If appointed injection solution injections are done intravenously or intramuscularly. Sometimes the drug is administered drip.

Not allowed simultaneous reception this drug with alcohol. A 12-hour interval must be observed. If Piracetam is prescribed to relieve a hangover, before starting therapy, you need to prepare the patient's body:

  1. Restore water balance.
  2. Eliminate headaches with aspirin.
  3. Cleanse the body of toxins (activated charcoal is used for this).

Piracetam - dosage

This drug is used according to the standard scheme:

  1. Recommended daily dosage tablets and capsules for an adult is 1200 mg. This amount of the drug should be taken in 3 doses. In the absence of the expected result, the daily dosage is increased to 3200 mg. With the onset of improvement, the amount of the drug is reduced to 400 mg. In some cases, therapy lasts several months, and sometimes six months, followed by a decrease in dosage. It is impossible to cancel the drug abruptly!
  2. If Piracetam is prescribed to a child, the dosage is prescribed much less than for adults. Babies from 1 to 5 years old can take 800 mg per day (divided into 4 doses). For older children, the daily dosage increases to 1200-1600 mg. The recommended duration of therapy is 3 weeks.
  3. Piracetam is administered intravenously, starting with small doses (3-4 g). After 1-2 days daily rate increases to 5-6 g. With positive dynamics, the patient is prescribed Piracetam in tablets. Maximum duration injection therapy is 10 days.

Piracetam side effects

The drug is generally well tolerated by patients. However, some piracetam side effects calls. Such can be observed negative reactions body:

  • irritability;
  • confusion;
  • drowsiness or, conversely, insomnia;
  • hallucinations;
  • tremor;
  • increased sexual activity;
  • headache;
  • imbalance.

If Piracetam 400 is taken in in large numbers, it can cause such side reactions:

  • blood pressure decreases;
  • dermatitis appears on the skin, accompanied by severe itching;
  • observed sharp set weight;
  • there is an exacerbation of pathologies of the cardiovascular system;
  • there is nausea with vomiting and diarrhea.

Piracetam - contraindications for use

Although this drug is often prescribed in medical practice, there are a number of conditions in which the use of this medicine is prohibited. Piracetam contraindications are as follows:

  • after a recent hemorrhagic stroke;
  • strong psychomotor agitation at the time of drug administration;
  • intolerance to one of the components present in the composition of the drug;
  • Gintington's chorea;
  • lactation period;
  • children's age (up to 1 year).

Pregnancy is also included in the list of contraindications to the appointment of Piracetam. According to the manufacturers of this drug, the drug enters the body of the baby through the placenta and accumulates in its brain. In the future, this may lead to nervous breakdown baby. However, in practice, this drug is still used. It is prescribed in cases where the threat to the health of the mother is much higher than the risk to the fetus.

Students are always trying to find some loopholes so as not to study and pass the exam normally. This is not the case, some may argue. In fact, roundabout ways can also lead to a solution to the problem. Students do not hesitate and pharmacological preparations. Almost everyone knows what piracetam what this drug is prescribed for and when it is necessary to start using it.

Nutrition or structure - which is more important?

What is the most important thing for a student and any student? Of course brain activity, because its good performance allows:

  1. memorize all from the first time and for a long time.
  2. Faster read and absorb information.
  3. Boost speed reaction, decision making.
  4. Get rid of problems with insomnia and headache.

For normal functioning a combination of two indicators is needed - normal structure and good nutrition this system.

Structure pathologies

Eating disorders.

Traumatic injury can lead to hematomas- long-term non-absorbable accumulations of blood in the tissues.

Complete interruption of oxygen supply to the brain leads to death, already after 10 minutes the process becomes irreversible.

At the site of injury, patches form after some time. connective tissue . The substance of the brain is replaced by an ordinary scar.

Vascular pathologies lead to ischemia - a certain part of the brain ceases to be supplied with blood. The consequences depend on the scale.

Congenital anomalies and pathologies development cannot be ruled out, in recent years their percentage has increased significantly.

Errors in nutrition and severe general conditions can lead to the development lack of glucose to nourish the brain.

The first signs of pathology.

Exactly Glucose provides the brain with the main source of energy. to control the whole body. Little sleep? Are you engaged in intense intellectual work? Forgotten when in last time did you eat well? Don't be surprised if you soon notice the first problems with the central nervous system. Forgetfulness, irritability, insomnia can be combined with chronic fatigue.

In order not to take a difficult or uninteresting subject, the student is ready to spend much more time studying the features of the brain and human memory.

There are many methods on the network that promise to teach you to read a page a minute, memorize hundreds of numbers in a few seconds, and stuff like that. It is difficult to judge the real effectiveness of all these benefits, moreover, they always require perseverance and a waste of one's own time. And if you also need to make an effort, the option seems completely uninteresting.

How will Piracetam help?

The solution was found a long time ago, but it has become popular over the past decade. His name is nootropics:

  • Substances directly affect central nervous system. No intermediaries, passing through the barrier, they directly affect our brain.
  • Contain GABA- one of the main mediators, which ensures the transmission of impulses in the brain tissue. The more mediator, the more often and faster impulses pass. The faster thoughts are formed, information is fixed.
  • Due to the action at the cellular level, drugs increase the absorption of nutrients.
  • Raise body endurance and reduce the need for sleep. In the new conditions, rest is no longer so necessary; with large doses, cheerfulness can be felt even for several days.
  • The amount of long-term memory increases, it becomes really easier to memorize. But at the same time, you need to read, only taking the medicine will not work.

"Piracetam" belongs to the group of nootropics , thanks to its low price and non-prescription, it has become one of the most popular drugs among the student brethren.

The right approach to treatment with Piracetam

Let's talk about the dosage of the drug. AT preventive purposes , it is recommended to use no more than 1.2 mg per day. One tablet contains 0.2 mg, conveniently divided into three doses before or after meals.

There are also 0.4mg capsules for those who don't want to mess around with huge amount tablets. And we are slowly approaching the sad moment: the drug acts due to cumulation in the body. It is the accumulation and continuous intake of new doses that helps maintain changes in brain activity. Course duration at least 21 days, only after this period can we talk about some real effect. By increasing the dosage, the process can be accelerated, but at the same time, side effects may occur in the form of:

  • Weaknesses.
  • Drowsiness.
  • Irritability.
  • Headache.

They will appear with greater strength. Yes, and it is unrealistic to reduce the period from 21 to 1 day, we can talk about at least 1-2 weeks.

It will do you good if you have already taken this remedy, repeated use in high doses can lead to the appearance of positive effect in a short time.

How realistic is the action of Piracetam? It all depends on the person, some say a significant increase in the ability to remember, others do not see much results. Self-esteem plays a huge role, the placebo effect has not been canceled. According to some reviews and studies, we can only say that it is really increasing the rate of reading books. In the West, the drug is not considered a drug at all - positive impact not proven in experiments. He is considered biologically active additive- BAV.

What diseases are prescribed?

But our doctors do not refuse the use of Piracetam. Psychiatrists and narcologists like to prescribe it with the following diseases:

  • Schizophrenia.
  • Addiction.
  • Alcoholism.

All these diseases lead to serious problems With functional activity brain sometimes there may be organic damage. The drug is prescribed in "shock" doses, depending on the gender, age and physique of the patient. It is also of great importance degree of disease progression.

Not only visitors to narcological dispensaries and psychiatric hospitals receive these drugs.

in neurology, especially children's, it's popular prophylactic . To strengthen and normalize the general condition, it is prescribed in combination with other medicinal substances. Allergy tests are not carried out, but the condition of the kidneys and liver is monitored. It is with the help of these organs that piracetam is removed from the body.

Carefully it is prescribed for depression, in some of its types the drug is generally contraindicated.

If you have Piracetam tablets on your desktop, what this drug is prescribed for, you should know. Take it calmly, just remember that the urge to urinate may become more frequent. Reminds of itself excretion with the help of the kidneys.

Video about the appointment of Piracetm

Unfortunately, various violations circulation and metabolic processes in brain tissues are not uncommon - both children and adults suffer from such diseases. And quite often in similar situations doctors prescribe the drug "Piracetam". Reviews of experts indicate that the medicine is really effective and quickly eliminates the symptoms. But many patients are interested in information about the composition and properties this tool.

The drug "Piracetam": composition and form of release

The main active ingredient in this remedy is piracetam, which has nootropic properties. As for excipients, their content depends on the form of release. The drug "Piracetam" is available in the form of tablets, each of which contains 0.2 g of the active substance. In capsules, the level of piracetam is higher - 0.4 g. In addition, the drug is available in the form of solutions for intramuscular and intravenous administration(each ampoule contains 5 ml of solution, 1 g of active substance). For children, the medicine is recommended in granules for the preparation of suspensions.

The main properties of the drug

Piracetam is a modern nootropic drug that affects brain tissue. Specifically, it increases the concentration of ATP, creating additional source energy for neurons. Besides, active substance drugs accelerates the utilization of glucose, and also stimulates the synthesis of phospholipids and DNA. Thus, the tool helps to facilitate the learning process, enhance the integrative activity of the brain, and improve memory. Piracetam also inhibits platelet aggregation and improves microcirculation in brain tissues, enhances alpha and beta activity, protects nervous tissues from damage caused oxygen starvation, electric shock, poisoning, etc. This medicine really helps to improve blood circulation and increase performance. Along with this, piracetam has practically no sedative and psychostimulating effect.

Indications for use

AT modern medicine widely used drug "Piracetam". Reviews of experts indicate that the medicine can help in the treatment of a mass of pathologies.

  • First of all, the indication for admission is chronic cerebrovascular insufficiency, as well as some other circulatory disorders, including vascular parkinsonism and cerebral atherosclerosis. Similar diseases, as a rule, are accompanied by headaches, dizziness, impaired attention, speech and memory. The drug helps to eliminate almost all symptoms.
  • The drug is used to treat various disorders in the functioning of the nervous system, including those accompanied by a decrease in intelligence and impaired emotional state. In particular, the drug is used to treat schizophrenia, depressive states, asthenia, ideational retardation and some other mental disorders.
  • The drug is also used in modern pediatrics - indications for admission are encephalopathy and cerebrosthenic disorders.
  • In combination with other drugs, Piracetam is used to treat senile dementia.
  • Sometimes the drug is prescribed to patients with neuroinfections.
  • In addition, this nootropic drug is used to treat chronic alcoholism and drug addiction. It is also prescribed for acute poisoning ethanol, barbiturates and morphine.

Instructions for use

In fact, only a doctor can prescribe the drug "Piracetam". Reviews, as well as statistics, indicate that misuse medications can lead to a host of complications. Only a specialist can find out if you need to take a nootropic drug. In addition, the dose and schedule of administration are also determined individually. As for the recommended doses, the daily amount for adult patients can be determined at the rate of 30-160 mg per kilogram of body weight. The total amount of the drug should be divided into 2-4 doses. If a we are talking about the solution for injection, the initial dose for patients is approximately 10 g per day (with severe conditions it can be increased up to 12 g). If in the first few days the doses are large, then as the main symptoms disappear, the daily amount of the drug is reduced. For achievement maximum effect treatment should last at least 6-8 weeks. Children are usually prescribed powders for the preparation of a suspension. The daily dose is 30-50 mg per kilogram of body weight - total should be divided into 2-3 doses. The duration of therapy for children is three weeks.

Are there any contraindications for admission?

Not all patients can take this drug, although the list of contraindications in this case relatively small. For example, a drug should not be given to people with hypersensitivity to any of its components. Moreover, a history of allergic reactions on fruit juices and essences is also a contraindication. The drug is not recommended for children under the age of one year, although in some cases the treatment of infants is possible - this should be decided solely by the attending physician. The drug is not used to treat patients suffering from acute renal failure and diabetes.

The drug "Piracetam": side effects

Of course, like any other serious medicine, this drug can cause some adverse reactions. On the other hand, doctors quite often prescribe Piracetam to children. Reviews indicate that even in the smallest patients, side effects are relatively rare. Most often, violations appear when taking sick doses (more than 5 g of piracetam per day). In some cases, digestive disorders are possible, in particular nausea and vomiting, diarrhea and constipation, loss of appetite, gastralgia. Sometimes there are also disorders of the nervous system, including headaches, dizziness, tremors, convulsions. Various mental disorders are possible, including hyperexcitability, imbalance, anxiety, constant irritability, sleep disturbances, problems concentrating, increased sexual activity. In the presence of similar symptoms it is best to immediately consult a doctor - you may have to stop taking the medicine.

Additional Information

Store the medicine in a dry, dark place. It should be noted that the drug may interact with other drugs. In particular, the drug "Piracetam" enhances the effect of taking psychostimulants, indirect anticoagulants and neuroleptics. In addition, the drug increases the activity of hormones thyroid gland. In the event that evening medication affects the quality of sleep (for example, causes insomnia), it is worth changing the schedule of use. Experts also do not recommend abruptly stopping treatment with this drug - it is better to cancel it gradually.

The drug "Piracetam": reviews of specialists and patients

In fact, problems with the functioning of the central nervous system occur quite often. And in such cases, doctors usually prescribe nootropic drugs, in particular the drug "Piracetam". Reviews indicate that the medicine is really effective. Correct Reception this remedy helps to improve blood circulation and trophism of nerve tissues, which, of course, affects well-being and mental capacity patient. To undeniable advantages drugs can also be attributed to its relatively low cost - analogues of this drug are much more expensive.

INSTRUCTIONS for medical use drug

Registration number:

Tradename:

Piracetam

International non-proprietary name:

Piracetam

Dosage form:

coated tablets film sheath

Composition per tablet:

Dosage 800 mg
Active substance:
piracetam - 800.0 mg.


croscarmellose sodium - 12.0 mg, pregelatinized starch - 12.0 mg, povidone (polyvinylpyrrolidone) - 20.0 mg, magnesium stearate - 8.0 mg.


hypromellose - 15.2 mg, macrogol-4000 - 4.0 mg, titanium dioxide - 8.8 mg.

Dosage 1200 mg
Active substance:
piracetam -1200.0 mg.

Auxiliary substances (core):
croscarmellose sodium - 18.0 mg, pregelatinized starch - 18.0 mg, povidone (polyvinylpyrrolidone) - 30.0 mg, magnesium stearate - 12.0 mg.

Auxiliary substances (shell):
hypromellose - 22.8 mg, macrogol-4000 - 6.0 mg, titanium dioxide - 13.2 mg.

Description:

Dosage 800 mg
Capsule-shaped biconvex tablets, film-coated white or almost white color, with a risk on one side. A slight surface roughness is allowed. Two layers are visible on the fracture - the core is white or almost white and the film shell.

Dosage 1200 mg
White or almost white, oval, biconvex, film-coated tablets with a score line on one side. A slight surface roughness is allowed. Two layers are visible on the fracture - the core is white or almost white and the film shell.

Pharmacotherapeutic group:

Nootropic agent.

ATX code

N06BX03.

Pharmacological properties

Pharmacodynamics
The active ingredient is piracetam, a cyclic derivative gamma-aminobutyric acid(GABA).

Available data suggest that the main mechanism of action of piracetam is not cell specific or organ specific.

Piracetam binds to the polar heads of phospholipids and forms mobile drug-phospholipid complexes. As a result, a two-layer structure is restored cell membrane and its stability, which in turn leads to the restoration of the three-dimensional structure of membrane and transmembrane proteins and the restoration of their function.

At the neuronal level, piracetam facilitates different types synaptic transmission, having a predominant effect on the density and activity of postsynaptic receptors (data obtained from animal studies). Piracetam improves functions such as learning, memory, attention and consciousness without sedating or psychostimulating effects.

The hemorheological effects of piracetam are associated with its effect on erythrocytes, platelets and the vascular wall.

In patients with sickle cell anemia, piracetam increases the ability of red blood cells to deform, reduces blood viscosity and prevents the formation of "coin columns". In addition, it reduces platelet aggregation without significantly affecting their number.

Animal studies have shown that piracetam inhibits vasospasm and counteracts various vasospastic substances.

In studies on healthy volunteers, piracetam reduced the adhesion of erythrocytes to the vascular endothelium and stimulated the production of prostacyclins by healthy endothelium.

Pharmacokinetics
Suction.
After oral administration, piracetam is rapidly and almost completely absorbed from gastrointestinal tract. The bioavailability of piracetam is close to 100%. After a single dose of the drug at a dose of 3.2 g, the maximum concentration (Cmax) is 84 μg / ml, after repeated administration of 3.2 mg 3 times a day - 115 μg / ml and is achieved after 1 hour in blood plasma and after 5 hours in cerebrospinal fluid. Eating reduces C max by 17% and increases the time to reach it (T max) up to 1.5 hours. In women, when taking piracetam at a dose of 2.4 g, Cmax and the area under the concentration-time curve (AUC) are 30% higher than in men.

Distribution.
The volume of distribution (Vd) is about 0.6 l/kg. Piracetam crosses the blood-brain and placental barriers. In animal studies, it was found that piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia.

Metabolism.
Does not bind to plasma proteins, is not metabolized in the body.

Withdrawal.
The half-life (T1 / 2) is 4-5 hours from blood plasma and 8.5 hours from cerebrospinal fluid. The elimination half-life does not depend on the route of administration. 80-100% of piracetam is excreted by the kidneys unchanged by glomerular filtration. The total clearance of piracetam in healthy volunteers is 80-90 ml / min. T1/2 lengthens at kidney failure(with terminal chronic renal failure - up to 59 hours). Pharmacokinetics
piracetam does not change in patients with hepatic insufficiency.

Indications for use:

In adults

Symptomatic treatment psychoorganic syndrome, in particular, in elderly patients, accompanied by memory loss, dizziness, reduced concentration attention and decreased activity, mood changes, conduct disorder, gait disturbance (these symptoms may be early signs age-related diseases such as Alzheimer's disease and senile dementia of the Alzheimer's type);
- Treatment of vertigo and related imbalance, with the exception of vascular and psychogenic dizziness;
- Complex therapy and monotherapy for cortical myoclonus;

Treatment of dyslexia (in combination with other methods);
- Complex therapy of sickle cell anemia (for the prevention of sickle cell vaso-occlusive crisis).

Contraindications:

- Individual intolerance to piracetam or pyrrolidone derivatives, as well as other components of the drug;
- psychomotor agitation at the time of prescribing the drug;
- Huntington's chorea;
- Acute violation cerebral circulation (hemorrhagic stroke);
- The end stage of renal failure (with creatinine clearance less than 20 ml / min);
- Childhood up to 3 years.

Carefully:
violation of hemostasis; extensive surgical interventions; heavy bleeding; chronic renal failure (with creatinine clearance 20-80 ml / min).

Use during pregnancy and lactation

Controlled studies of the use of the drug during pregnancy have not been conducted. Piracetam crosses the placental barrier and breast milk. The concentration of the drug in newborns reaches 70-90% of its concentration in the blood of the mother. Piracetam should not be given during pregnancy. During lactation, the issue of stopping breastfeeding should be resolved.

Dosage and administration

inside.

During a meal or on an empty stomach, drinking liquid.

Symptomatic treatment of psychoorganic syndrome: 2.4 - 4.8 g / day in 2-3 doses.

Treatment of dizziness and related imbalance: 2.4 - 4.8 g / day in 2-3 doses.

Treatment of cortical myoclonus: start with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until maximum dose 24 g / day in 2-3 doses. Treatment is continued throughout the entire period of the disease. Every 6 months, attempts should be made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g / day every 2 days.

Treatment of sickle cell anemia: The daily prophylactic dose is 160 mg/kg of body weight, divided into 4 equal doses.

Treatment of dyslexia in children (in combination with other methods of treatment): recommended daily dose for children from 8 years old and adolescents - 3.2 g, divided into 2 doses.

Dosage in patients with impaired renal function: the dose should be adjusted depending on the value of creatinine clearance (CC):
Creatinine clearance for men can be calculated from serum creatinine concentration using the following formula:

For elderly patients, the dose is adjusted in the presence of renal insufficiency; with prolonged therapy, control is necessary. functional state kidneys.

Dosage in patients with impaired liver function:
patients with impaired liver function do not need dose adjustment. Patients with impaired function of both the kidneys and the liver, dosing is carried out according to the scheme (see section "Dosing in patients with impaired renal function").

Side effect

From the nervous system: motor disinhibition, irritability, drowsiness, depression, asthenia, headache, insomnia, agitation, imbalance, ataxia, exacerbation of the course of epilepsy, anxiety, hallucinations, confusion.

From the side digestive system: nausea, vomiting, diarrhea, abdominal pain (including gastralgia).

From the side of metabolism: weight gain.

From the hearing organs: vertigo.

From the side skin: dermatitis, itching, urticaria.

Allergic reactions: angioedema, hypersensitivity, anaphylactic reactions.

Overdose

Symptoms: diarrhea with an admixture of blood, pain in the abdomen.

Treatment: in case of significant overdose, gastric lavage or induction of vomiting should be performed. Recommended symptomatic therapy which may include hemodialysis. There is no specific antidote. The efficiency of hemodialysis for piracetam is 50-60%.

Interaction with other drugs

The possibility of changing the pharmacokinetics of piracetam under the influence of other medicines low, because 90% of piracetam is excreted unchanged by the kidneys.

With simultaneous use with thyroid hormones, there have been reports of confusion, irritability and sleep disturbance.

According to a published study in patients with recurrent venous thrombosis piracetam at a dose of 9.6 g / day increases the effectiveness of indirect anticoagulants (there was a more pronounced decrease in the level of platelet aggregation, fibrinogen levels, von Willebrand factors, blood and plasma viscosity compared with the use of indirect anticoagulants only).

In vitro, piracetam does not inhibit cytochrome P450 isoenzymes, such as CYP1A2, 2B6, 2C8, 2C9, 2C19, 2B6, 2E1 and 4A9 / 11 at a concentration of 142, 426 and 1422 μg / ml. At a concentration of 1422 μg / ml, a slight inhibition of CYP2A6 (21%) and 3A4 / 5 (11%) was noted, however, the Ki level of these two isoenzymes is sufficient when exceeding 1422 μg / ml, and therefore metabolic interaction with other drugs is unlikely.

Taking piracetam at a dose of 20 g / day for 4 weeks did not change the maximum serum concentration and the area under the concentration-time curve of antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproic acid).

Co-administration with alcohol did not affect the concentration of piracetam in serum; the concentration of ethanol in the blood serum did not change when taking 1.6 g of piracetam.

special instructions

In the treatment of cortical myoclonus, abrupt interruption of treatment should be avoided, as this may cause the resumption of attacks.
In the treatment of sickle cell anemia, a dose of less than 160 mg / kg or irregular intake of the drug can cause an exacerbation of the disease.
Penetrates through the filtering membranes of hemodialysis machines.

Influence on the ability to drive vehicles and work with mechanisms

During the period of treatment, care should be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Release form:

Film-coated tablets 800 mg and 1200 mg.
10, 20, 30 tablets in a blister pack made of polyvinyl chloride film and printed lacquered aluminum foil.
10, 20, 30, 40, 50, 60, 80, 90, 100 or 120 tablets in polymer jars for medicines.
One jar or 1, 2, 3, 4, 5, 6, 8, 9, 10 or 12 blister packs together with instructions for use are placed in a carton (pack).

Storage conditions:

In a place protected from light at a temperature not exceeding 25 ° C.
Keep out of the reach of children.

Best before date:

3 years.
Do not use after the expiration date.

Conditions for dispensing from pharmacies:

On prescription.

Manufacturing firm:

OOO "Ozon"
Legal address: 445351, Russia, Samara region, Zhigulevsk, st. Pesochnaya, 11.

Address of the place of production (address for correspondence, including for receiving claims):

445351, Russia, Samara region, Zhigulevsk, st. Gidrostroiteley, d. 6.
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