Sulfocamphocaine contraindications. on the medical use of the drug. Drug group and scope

R.07.A.B Respiratory stimulants

INSTRUCTIONS

on the medical use of a medicinal product

Sulfocamphocaine-Darnitsa

(Sulfocamphocaine-Darnitsa)

active substances: DL-sulphocamphoric acid, novocaine;

1 ml of solution contains: DL-sulfocamphoric acid 49.6 mg; novocaine base 50.4 mg;

excipient: water for injections.

Dosage form. Injection.

Basic physical and chemical properties: clear colorless or slightly yellowish

liquid.

Pharmacotherapeutic group. cardiac drugs. ATX code С01E B.

Pharmacological properties

Pharmacodynamics.

Sulfocamphocaine-Darnitsa belongs to the group of analeptic drugs. The mechanism of action of the drug is due to the excitation of the central nervous system, primarily the centers of the medulla oblongata, both directly and through the carotid sinus. The drug tones the respiratory and vasomotor centers, enhances metabolic processes in the heart muscle, increasing its sensitivity to the influence of sympathetic nerves. Sulfocamphocaine-Darnitsa has a direct effect on the vessels - redistribution of blood occurs, the vessels of the abdominal organs narrow, the tone of the venous vessels increases, blood flow to the heart slightly increases, coronary blood flow, blood supply to the brain and lungs improves. The cardiotonic effect is associated with an adrenosensitizing effect, an increase in the processes of respiration and glycolysis associated with the process of phosphorylation of macroergic compounds.

Pharmacokinetics.

Sulfocamphocaine-Darnitsa is rapidly absorbed by subcutaneous, intramuscular, intravenous administration. In the body, in the process of metabolism, it undergoes oxidation and conjugation with glucuronic acid. Metabolites are excreted mainly by the kidneys, while the urine has a drug odor. Partially excreted with exhaled air, through the respiratory tract and with bile.

clinical characteristics.

Indications

Acute and chronic respiratory failure; acute heart failure in geriatrics; respiratory depression in pneumonia and other infectious diseases; cardiogenic and anaphylactic shock; alcohol poisoning, mild forms of poisoning with sleeping pills.

Contraindications

Hypersensitivity to camphor, novocaine or other components of the drug; epilepsy, a tendency to convulsive reactions.

Interaction with other drugs and other types of interactions.

With the simultaneous use of Sulfocamphocaine-Darnitsa with other drugs, it is possible:

with drugs that depress the central nervous system -

with anticholinesterase agents - weakening the action of the latter;

with suxamethonium - prolongation of the neuromuscular blockade caused by suxamethonium;

with MAO inhibitors- increased risk of arterial hypertension;

with cardiac glycosides, diuretics, analgesics, steroid hormones- increased analeptic action of sulfocamphocaine.

The drug can sometimes be prescribed to reduce the side effects of chemotherapy with 5-fluorouracil.

During the use of the drug is not recommended to drink alcohol.

Application features

Use with caution in patients with arterial hypotension (hypotensive effect of novocaine).

Use during pregnancy or lactation.

In evidence-based medicine, there is no objective information on the use of Sulfocamphocaine-Darnitsa during pregnancy, so pregnant women should not use the drug. The possibility of penetration of Sulfocamphocaine-Darnitsa into milk during lactation is not excluded, therefore, when using the drug, it is necessary to stop breastfeeding.

The ability to influence the rate of reactions when driving vehicles or using other mechanisms.

During treatment, care should be taken when driving vehicles and working with complex mechanisms, and in case of dizziness, refrain from working with potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Dosage and administration

Sulfocamphocaine-Darnitsa is administered subcutaneously, intramuscularly or intravenously (slowly, by stream or drip) to adults in a single dose of 2 ml. For dilution, a 0.9% sodium chloride solution should be used. If necessary, the drug can be used 2-3 times a day. The maximum daily dose for adults is 12 ml.

In acute cases, the drug is administered intravenously.

In chronic respiratory failure and heart failure, apply intramuscularly or subcutaneously. The course of treatment can be 20-30 days.

Children.

The drug should not be used in children.

Overdose

Symptoms: headache, dizziness, in case of acute poisoning - redness of the face, pathological motor activity, delirium, epileptiform convulsions.

Treatment: antipsychotics and anticonvulsants. With unexpressed psychomotor agitation - tranquilizers or sedatives.

Adverse reactions

From the gastrointestinal tract: dyspeptic disorders.

From the nervous system: headache, dizziness, tremor, paresthesia, convulsions.

From the side of the cardiovascular system: decrease or increase in blood pressure, palpitations, chest pain.

From the blood and lymphatic system: methemoglobinemia.

From the immune system: hypersensitivity reactions, including angioedema, anaphylactic shock, skin rashes, itching, hyperemia, urticaria.

General disorders and reactions at the injection site: hyperemia, rashes and itching at the injection site.

Others: fever, involuntary urination.

Best before date

Storage conditions

Keep out of the reach of children in the original packaging at a temperature not exceeding 25 °C. Do not freeze.

Package

2 ml in an ampoule; 5 ampoules in a blister pack; 2 blisters in a pack.

On prescription.

Manufacturer

PJSC “Pharmaceutical firm “Darnitsa”.

Location of the manufacturer and its address of the place of business.

Ukraine, 02093, Kyiv, st. Borispolskaya, 13.

It is an auxiliary substance.

Release form

Injection solution, in a package of 10 ampoules of 2 ml.

pharmachologic effect

The formula of the drug, which consists of two substances, allows you to get a pronounced analeptic effect . The drug stimulates the vasomotor and respiratory centers, affecting the structures medulla oblongata.

Directly affects myocardium, increasing its sensitivity to stimulation sympathetic nervous system and improving metabolic processes in tissues.

Under the influence of the drug, the tone of the blood vessels in the periphery increases. The secretion of bronchial glands is stimulated and pulmonary blood flow improves, increasing ventilation of the lungs.

Pharmacodynamics and pharmacokinetics

Rapidly absorbed by any route of administration. The main part of the drug is excreted by the kidneys, giving the urine a specific odor.

Indications for use

The use of Sulfocamphocaine is indicated for:

• cardiogenic shock ;
• acute heart failure ;
• acute pulmonary insufficiency .

Contraindications

Individual hypersensitivity to components.

Side effects

• arterial hypotension ;

Instructions for use Sulfocamphocaine (Method and dosage)

Apply parenterally, Sulfocamphocaine is administered intravenously, intramuscularly or subcutaneously, at a dose of 2 ml. The frequency of administration is up to three times a day. The maximum amount for administration is up to 6 ampoules per day. The instruction on Sulfocamphocaine determines the course of treatment of chronic heart or respiratory failure for a period of about one month.

Overdose

children

not assigned because camphor may increase seizure activity in a child.

During pregnancy and lactation

Apply with caution, since there are no data on the safety of use in this period.

Reviews about Sulfocamphocaine

On the forums you can find numerous reviews about the medicine. Doctors prescribe it in many cases, even which are not in the testimony. For example, the use of the drug for. Injections are prescribed for acute conditions, old people after injuries (hip fracture) to reduce congestion in the lungs, maintain the heart and circulatory system.

Tolerability is generally good, subject to doses and regimen. Be careful when taking hypotensive patients because the drug lowers blood pressure.

Sulfocamphocaine for dogs is widely used in a wide variety of cases and diseases, as it stimulates and supports well. cardiovascular system in animals. The drug is used in the same way for cats - there are reviews of the use both for injuries (for example, after being hit or hit by a car) and for liver diseases in pets. Of the shortcomings, it is noted that injections cause weakness in animals, apparently due to a drop in pressure.

Sulfocamphocaine price, where to buy

The price of Sulfocamphocaine in Moscow is 149 rubles. The average price in Russia is from 99 to 168 rubles. per pack of 10 ampoules.

Sulfocamphocaine - a combination drug based on novocaine and camphor used both for the treatment and prevention of circulatory disorders caused by infectious diseases, as well as in acute cardiopulmonary insufficiency.

Release form Sulfocamphocaine

Sulfocamphocaine is produced as a solution for injection, in 2 ml ampoules containing 100 mg of the active substance - novocaine and sulfocamphoric acid.

Analogues of Sulfocamphocaine are medicines:

• According to the active substance - Sulfocaine and Sulfoprocaine;
• According to the mode of action - Ammonia, Cordiamin, Securinin nitrate, Etimizol, Cordiamin-Ferein, Armanor, Niketamid-Eskom.

pharmachologic effect

The active components of Sulfocamphocaine have an analeptic effect.

The effect of the use of Sulfocamphocaine according to the instructions is due to the camphor and novocaine that are part of the drug.

A distinctive feature from other drugs with a similar effect is the rapid absorption when administered subcutaneously, as well as the high safety of the drug.

As a result of the use of Sulfocamphocaine:

• The tone of peripheral blood vessels increases;
• Metabolic processes are intensifying (due to a direct effect on the myocardium);
• Improves ventilation of the lungs and pulmonary blood flow;
• The sensitivity of the myocardium to sympathetic impulses increases;
• The secretion of the bronchial glands is increased.

Indications for the use of Sulfocamphocaine

According to the instructions, Sulfocamphocaine is prescribed for:

• Acute and chronic heart failure;
• Cardiogenic shock;
• Acute cardiopulmonary failure;
• Hypotension;
• collapse;
• Anaphylactic shock.

In addition, according to the instructions, Sulfocamphocaine is used for circulatory disorders caused by infectious diseases. So, the drug is indicated for the prevention and treatment of:

• pneumonia;
• Purulent pleurisy;
• Narcotic and drug poisoning.

Contraindications

Sulfocamphocaine is contraindicated in case of existing hypersensitivity to the components that make up the solution.

As a rule, Sulfocamphocaine according to reviews is prescribed with caution in the following cases:

• With arterial hypotension;
• During breastfeeding;
• During pregnancy.

How to use Sulfocamphocaine

Most often, Sulfocamphocaine is administered subcutaneously. In some cases, according to indications, the drug can be administered intramuscularly and intravenously (both jet and drip).

The standard dosage is 2 ml of a 10% solution of Sulfocamphocaine, two to three times a day. A maximum of 12 ml of solution can be administered per day.

In most cases, the duration of the use of Sulfocamphocaine according to reviews is set individually.

In the treatment of chronic heart and respiratory failure, the drug is administered for 20-30 days (subcutaneously or intramuscularly).

Side effects

Sulfocamphocaine, according to reviews, can cause a sharp decrease in pressure, which is most often observed with existing hypotension.

In addition, with a predisposition, Sulfocamphocaine can lead to the development of allergic skin reactions in the form of itching and redness (at the injection site).

Drug Interactions Sulfocamphocaine

Sulfocamphocaine according to the instructions can be used simultaneously with steroid hormones, cardiac glycosides and analgesics.

Storage conditions

Sulfocamphocaine refers to drugs with analeptic action, for which a prescription is required for dispensing from pharmacies. The shelf life of the solution should not exceed three years (at temperatures up to 25 ° C).

Sincerely,

Sulfocamphocaine- a cardiological drug, belongs to the group of analeptic drugs. The mechanism of action of the drug is due to the excitation of the central nervous system, primarily the centers of the medulla oblongata, both directly and through the carotid sinus. The drug tones the respiratory and vasomotor center, enhances metabolic processes in the heart muscle, increasing its sensitivity to the influence of sympathetic nerves.
Sulfocamphocaine affects the blood vessels - redistribution of blood occurs, the vessels of the abdominal organs narrow, the tone of the venous vessels increases, blood flow to the heart slightly increases, coronary blood flow, blood supply to the brain and lungs improves. The cardiotonic effect is associated with an adrenosensitizing effect, an increase in the processes of respiration and glycolysis associated with the process of phosphorylation of macroergic compounds.

Pharmacokinetics

Indications for use

Mode of application

Side effects

Contraindications

Pregnancy

Interaction with other drugs

Overdose

Storage conditions

Release form

Compound

Additionally

main parameters