Instructions for use of Mexidol injections. Mexidol, solution for intravenous and intramuscular administration

Antioxidants are antioxidants that protect against free radicals. Due to the effect they have, they are prescribed for the complex treatment of many pathological processes associated with impaired blood circulation and intoxication. Among this group, Mexidol can be distinguished. It is available both in the form of a solution in ampoules (2 and 5 ml) for injection, and in the form of tablets. The drug is produced in the Russian Federation, therefore it has a very affordable price. According to experts, for the best effect, it is first recommended to give Mexidol injections, and only then switch to the tablet form.

For more convenient use, Mexidol is available in ampoules and tablets. Each of these forms has its own characteristics and method of application:

• Ampoules. In one package, there are usually 5-10 containers with a solution. The ampoule can be 2, 5 and 10 ml. Injections of Mexidol intramuscularly should be done only in mild cases. How much to inject the medicine should be said by the attending physician, focusing on the patient's condition. In severe cases, injections are given mainly intravenously. Two types of input are used for this purpose:
  • Dropper. In this option, the speed must be made no more than 1 drop per second;
  • jet method. This type of procedure lasts about 5 minutes, depending on the amount of the drug.
• Tablets. They are quickly absorbed into the blood through the stomach. The tablets will be in the body for about 5-6 hours from the moment of administration. The decay occurs in the patient's liver, and the drug is excreted in the form of urine. Mexidol in tablets differs from ampoules in that it can cause additional side effects in the patient's gastrointestinal tract (constipation, diarrhea, etc.) and enters the blood more slowly.

Before using the drug, you need to find out what it helps. A neurologist can talk about this, as well as instructions for use and reviews left by people and doctors about this medication.

Features of the drug

The drug relaxes muscle tissue well, prevents cells from oxidizing, stimulates blood circulation and removes harmful substances from the body. Many doctors note its sedative effect and the ability to have a beneficial effect on the human autonomic system. Such results are achieved due to the main active substance (ethylmethylhydroxypyridine succinate), which has a positive effect on the outer membrane of cells. Due to this effect, an accelerated synthesis of dopamine occurs in the patient's brain. It is a special neurotransmitter capable of raising mood and increasing working capacity.

The scientists who created this medication claim that the list of what Mexidol helps from includes an effect on hematopoiesis and on the blood flow itself. This effect will be especially appreciated by people suffering from poor vascular patency, anemia and high blood cholesterol levels.

A sedative effect on the nervous system helps patients who suffer from panic attacks, anxiety, depression and other mental disorders.

Mexidol injections quickly stop such manifestations. After completing the course of injections, negative consequences, for example, addiction, are not left.

You can prick with a stroke, as it improves cerebral (cerebral) circulation and serves as a prophylactic against relapses. Among its other advantages, one can single out good compatibility with most known medicines. That is why Mexidol is used in many treatment regimens as the main or additional treatment.

Indications for use

Mexidol has its indications for use, namely:

• Intoxication, which is the result of long-term use of antipsychotics or alcohol;
• Neuroses of a different nature;
• Glaucoma;
• Traumatic brain injury;
• Inflammatory processes with the release of pus in the gastrointestinal tract and abdominal organs;
• stroke and heart attack;
• Developing cerebral ischemia;
• epileptic seizures.

Instructions for use

The attending physician should tell you how to take the tablets at the appointment. After all, the treatment plan is compiled on the basis of the results of the examination. In the future, it is adjusted depending on the results obtained. The duration of use of Mexidol in the table. usually does not exceed 2 months. It is allowed to use no more than 600 mg per day.

Injections are mainly given in medical institutions. They are done intravenously or intramuscularly, depending on the pathological process and the individual characteristics of the patient. The dose is selected by the neurologist after diagnosis. The patient's body weight is taken into account. The duration of the course is selected individually depending on the pathological process and usually does not exceed 1 month. The maximum allowable dose is 1200 mg per day. When the desired result is achieved, the doctor will recommend switching to a tablet form for preventive purposes. You can take pills at home.

The procedure for injecting the drug

After drawing up a treatment regimen and receiving a prescription, you must purchase a 5% solution of Mexidol at the pharmacy. Next, you can proceed to the injection procedure, and how to inject can be seen below:

• Intravenous method:
  • Drip introduction. First you need to open the ampoule and pour its contents into 200 ml of saline. The introduction of the drug is carried out using a dropper at a rate of 60 drops per minute;
  • Jet introduction. In this case, it is not necessary to dilute the contents of the ampoule, since it is enough to slowly inject the medicine into the vein. However, you will have to stand nearby for about 5 minutes.
• intramuscular method. This injection is often done at home. For the correct administration of the drug, it is enough to make an injection in the upper central square of the gluteal muscle.

Side effects

All groups of medicines have certain side effects. In most cases, they are the result of an incorrectly selected dosage, intolerance to the composition, or the wrong combination of drugs. After an injection with a solution of Mexidol, such undesirable reactions most often appear:

• Nausea flesh to vomiting;
• The manifestation of allergies;
• General weakness;
• disturbed sleep rhythm;
• Dryness in the mouth;
• Low work capacity.

The tablet form has the same side effects, but you can still add a negative effect on the gastrointestinal tract to them:

• Bloating and spasm of the stomach;
• Heartburn;
• Diarrhea or diarrhoea.

In rare cases, after the use of Mexidol, pressure decreases and sweating increases, especially of the palms and feet. Against this background, the patient may experience sudden changes in mood. However, all the negative effects of taking this drug quickly disappear after its withdrawal.

Contraindications

Mexidol has virtually no contraindications and is well tolerated in most cases. It is not recommended to use it only in such situations:

• Insufficiency of the liver and kidneys;
• The period of pregnancy and lactation (breastfeeding);
• Children's age up to 18 years;
• Composition intolerance.

The cost of the medication

The price of Mexidol in Moscow pharmacies is as follows:

• Price per tablet form:
  • 50 pcs. - 365-420 rubles;
  • 30 pcs. - 215-255 rubles.
• Price for ampoules:
  • 2 ml. 10 pieces. - 415-460 rubles;
  • 2 ml. 50 pcs. - 1945-2075 rubles;
  • 5 ml 5 pcs. - 410-465 rubles;
  • 5 ml 20 pcs. - 1565-1655.

Mexidol instructions for use. In this article, we will get acquainted with the instructions on how to use the drug Mexidol (Mexidol®) - what it helps from, its price and recommendations from customers. It is known from the instructions that this is Mexidol 125 mg film-coated tablets, Mexidol injections (in ampoules) of 5% of the drug for the treatment of encephalopathy, TBI and other brain disorders in adults, children and pregnancy.

Excipients: lactose monohydrate - 97.5 mg, povidone - 25 mg, magnesium stearate - 2.5 mg.

The composition of the film shell: Opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

• 10 pieces. - cellular contour packaging (1) - packs of cardboard;
• 10 pieces. - cellular contour packaging (2) - packs of cardboard;
• 10 pieces. - cellular contour packaging (3) - packs of cardboard;
• 10 pieces. - cellular contour packaging (4) - packs of cardboard;
• 10 pieces. - cellular contour packaging (5) - packs of cardboard.

Mexidol (Mexidol®) - instructions for use

To optimize the functioning of the body, it is appropriate to additionally drink a course of prescribed medications. Mexidol is worth choosing if you need to influence the body's resources, maintain the functions and tone of internal systems, especially the central nervous system organs. Unauthorized use of the drug is strictly contraindicated.

Compound

The active substance of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). Available injection solution (50g/l) or tablets containing 125 mg. active substance. This is a domestic drug, one of the new generation of antioxidant drugs.

As excipients, Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise - carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Tablets Mexidol instructions for use

Mexidol tablets are intended for oral administration. The daily dose varies from 375 to 750 mg, the multiplicity of doses is 3 (one or two tablets three times a day). The maximum allowable dose is 800 mg. per day, which corresponds to 6 tablets.

The duration of the course of treatment depends on the disease and the patient's response to the prescribed treatment. As a rule, it is from two weeks to one and a half months. In the case when the drug is prescribed to relieve the symptoms of alcohol withdrawal, the duration of the course is from five to seven days.

In this case, abrupt withdrawal of the drug is unacceptable: treatment is stopped gradually, reducing the dose within two to three days. At the beginning of the course, the patient is prescribed to take one or two tablets per dose once or twice a day. The dose is gradually increased until a positive clinical effect is obtained (while it should not exceed 6 tablets per day).

The duration of the therapeutic course in patients diagnosed with coronary disease is from one and a half to two months. If necessary, according to the doctor's prescription, a second course can be prescribed. The optimal time for the appointment of a second course is autumn and spring.

Mexidol from what is prescribed - indications for use

Why is Mexidol prescribed? The drug is indicated for the treatment of:

1. Vegetovascular dystonia;
2. Alcohol and drug addiction;
3. Discirculatory encephalopathy;
4. Atherosclerotic brain pathologies;
5. Consequences of acute disorders of cerebral circulation, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
6. Impact of extreme (stress) factors;
7. Conditions after acute intoxication with antipsychotics;
8. Anxiety disorders in neurotic and neurosis-like states;
9. Light traumatic brain injury, consequences of traumatic brain injury;
10. Acute pathologies of cerebral circulation.

Why is Mexidol taken and what helps? Mexidol is indicated for the removal of: "Withdrawal syndrome" and various conditions that occur during oxygen starvation.

Price for Mexidol

The cost of the drug is available to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately the same price range.

It is important to read the instructions before buying. The price on the Internet is cheaper, real and positive recommendations from patients, high efficiency of the drug. If you buy a medicine at a pharmacy, the price depends on the city and region. No prescription required.

Dosage and administration

Inside, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).
Duration of treatment - 2 - 6 weeks; for the relief of alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose within 2-3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets). The duration of the course of therapy in patients with coronary heart disease is at least 1.5 - 2 months. Repeated courses (on the recommendation of a doctor), it is desirable to conduct in the spring - autumn periods.

pharmachologic effect

According to the instructions for use, Mexidol is characterized by a complex pharmacological action, has an antioxidant, adaptogenic, nootropic, membrane-stabilizing, cerebroprotective, anxiolytic, vegetotropic, anticonvulsant effect:

• Restores the functions and structure of cell membranes, modulates membrane-bound enzymes, improves the interconnection of brain structures and synoptic transmission;
• Improves the function of the immune system, inhibits platelet aggregation;
• It activates the synthesis of protein and nucleic acids inside the cells, accelerates the enzymatic reactions of the Krebs cycle and the utilization of glucose, promotes the synthesis of ATP and its accumulation inside the cells;
• Improves cerebral hemodynamics, including microcirculation, has a positive effect on blood flow, limits the area of ​​cerebral ischemia and stimulates reparative processes;
• Lowers the level of low density lipoproteins and cholesterol, promotes the regression of atherosclerotic changes in the vessels;
• It inhibits fat peroxidation, activates the antioxidant system, accelerates mitochondrial energy synthesis, improves cellular energy metabolism.

Contraindications

1. Hypersensitivity to the drug;
2. Acute liver failure;
3. Acute renal failure.

Mexidol is not prescribed to children due to insufficient knowledge of the drug's action.

Side effects

On the part of the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Others: allergic reactions are possible.

Overdose

Overdose may cause drowsiness.

drug interaction

Mexidol can be combined with all drugs used to treat somatic diseases. When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants. Mexidol reduces the toxic effect of ethyl alcohol.

special instructions

Influence on the ability to drive vehicles and control mechanisms. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

For impaired renal function

The prescription drug is contraindicated in acute renal failure.

Mexidol injections instructions for use

The second form of release of this drug is a solution for injection. If ordinary Mexidol is prescribed in this form, ampoules (shots) are also dispensed without a prescription.

The release option is more effective, since the component - methylhydroxypyridine - immediately enters the systemic circulation, has a therapeutic effect, and gives a stable and lasting therapeutic effect. The medicine has antioxidant, nootropic, antihypoxic and anxiolytic properties. What helps Mexidol? Indications for use are as follows:

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open-angle glaucoma;
• Insufficient nutrition of brain tissue.

The medication Mexidol injections according to the instructions is injected into the patient's body into the muscle or intravenously. Single doses and the duration of the course is important to pre-specify with your doctor.

A similar annotation Mexidol instructions for use reports that a single dose of medication depends on the nature of the pathological process, the degree of neglect of the diagnosed disease. These may include the following rules:

1. Traumatic brain injury - 500 mg / 14 days;
2. Circulatory failure in the cerebral cortex - 100-250 ml / 10 days;
3. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
4. In the presence of mild cognitive impairment, older people inject about 300 mg / day into the muscle for up to thirty days;
5. Acute diseases of a purulent-inflammatory nature - from the first days of treatment and after the end of the operation. The required dosage is calculated by a specialist, the duration of the drug will depend on the form and severity of the disease. Features and characteristic features of its course. Cancellation of the drug Mexidol is carried out gradually, as soon as a stable clinical effect is achieved, blood counts stabilize;
6. With a mild course of necrotizing pancreatitis - up to 200 mg three times a day. Choose one of the methods of administration or use a combination of them;
7. With necrotizing pancreatitis, if it is severe, 800 mg is prescribed on the first day in a pulse dosage. For the following days, from 200 to 500 mg is prescribed twice a day;
8. Encephalopathy (injections can be done only in the decompensation phase) - intravenously, 200-400 mg of Mexidol twice a day for fourteen days. Over the next two weeks, about 200 mg are administered. 1 per day. A preventive measure occurs by injecting a solution intramuscularly at 250 mg. twice a day for two weeks;
9. In acute poisoning with antipsychotics, it is prescribed from 300-500 mg / day for a week;
10. In acute pancreatitis, accompanied by swelling, up to 500 mg of Mexidol is prescribed 3 times a day by drip or injection into the muscle;
11. With alcohol withdrawal, 250 mg / day is prescribed intravenously by drip or three injections into the muscle for one week.

The exact selection of the dosage of Mexidol should be carried out by a doctor. The introduction of Mexidol intravenously can be carried out by drip. Another injection technique is inkjet. It is administered directly into a vein using a syringe.

There is no need to dilute this solution. The speed of introduction of the ampoule is no more than seven minutes. If an injection of Mexidol is made into a muscle, then it is required to be done in the center of the upper quadrant of the buttock.

Mexidol during pregnancy

The drug does not help expectant mothers to recover quickly, but can only harm the intrauterine development of the fetus, provoke extensive pathologies. Clinical studies of such categories of patients were not carried out, therefore Mexidol is not prescribed during pregnancy. In addition, the drug is contraindicated during lactation.

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug.

Mexidol and alcohol compatibility

Mexidol instructions for use is an original drug with a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if you use the drug at the same time as alcohol, the effect of the latter can easily be neutralized. But this is just an erroneous assumption.

During the penetration of the substance into the body, the process of stopping the present pathology starts in it, while no protection is provided for the cells. Therefore, to the question of whether they can be used together, there is only one answer: it is impossible, since there is no compatibility between the substances.

Disobedience in this regard can cause serious negative consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Usually this technique helps to increase the effectiveness of therapy and the immediate elimination of disorders.

Thus, the drug is effective for eliminating numerous ailments and pathological phenomena, therefore, it will allow you to recover from any form of many diseases in just a short course. But before using the drug, it is recommended to consult a specialist.

Mexidol - analogues

If these injections give an allergic reaction, a correction of the treatment regimen is necessary. Drugs similar in composition to Mexidol also act productively, the main thing is to choose the safest drug in a particular clinical picture. Well-established, according to the recommendations of doctors, Cerecard, Mexiprim, Meksidant, Neurox, Mexicor.

Actovegin and Mexidol: The drugs have similar uses and are often given together. Actovegin is produced on the basis of an extract from calf's blood, so allergic reactions often develop on it. Improves nutrition and tissue regeneration. Unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and for the treatment of the consequences of such disorders - trophic ulcers and angiopathy.

What is better than Mexidol? Since the drug has recently appeared on the market, its research continues. In the case of a particular patient, those remedies that give the maximum effect are always good. If there is no improvement within two to three days of using Mexidol, it is better to replace it with other drugs. There is no single answer to the question of which drugs are better. The choice of treatment regimen is individual, and depends on the skill level of the attending physician.

Mexidol or Mexiprim? Mexiprim is a German drug, similar in its properties to the domestic Mexidol. Produced by the Stada Arzneimittel concern ("STADA Arzneimittel"). It differs only in the excipients included in the shell and the core of the tablets.

Mexidol or Cavinton? The active substance of Cavinton is a semi-synthetic derivative of vincamine (devincan) contained in periwinkle - vinpocetine. It is a vasodilator used to improve blood circulation in the brain. Slightly lowers blood pressure, improves the supply of glucose and oxygen to the brain.

It is also used in ophthalmology, and in the treatment of age-related diseases of the upper respiratory tract. Both drugs complement each other and are often used together in the treatment of cerebrovascular problems. It is undesirable to mix these drugs in one dropper, it is better to administer them separately.

Mexidol or Mildronate? Mildronate (trimethylhydrazinium propionate) is a vasodilator that improves oxygen supply to tissues, increases humoral and tissue immunity, lowers blood pressure, and is used in the treatment of coronary disease. It can be prescribed together with Mexidol for withdrawal symptoms, disorders of the blood supply to the brain, since the drugs complement each other.

Mexidol or Neurox? These two drugs are identical and contain the same active ingredient.

Mexidol or Cortexin? Cortexin contains an extract from bovine brain polypeptides. The choice of drug depends on the individual reaction of the patient's body to it. Together, both drugs are used in the treatment of acute cerebral hypoxia in newborns. It is prescribed only by the attending physician.

Mexidol or Nootropil? The active ingredient in Nootropil is piracetam. The drugs are often prescribed together to treat memory impairment, the effects of ischemic stroke, alcoholism, and improving learning in children.

Mexidol is included in the group of nootropics, improves metabolism in the brain. It acts directly on brain cells, protects them from oxygen starvation and from death as a result of ischemia.

Also, the drug delivers more oxygen to neurons from the blood, increasing the threshold for generating convulsive impulses in the brain. In the process of using Mexidol, a person recovers memory and skills lost as a result of a stroke or transient ischemic attack faster, improves memory, reproduction, speech, as well as resistance to various stressful situations and intoxications.

Mexidol: Instructions for use

Release form

Tablets Mexidol

Film-coated tablets from white to white with a creamy tint, biconvex, 30 or 50 tablets per pack. On the cross section, 2 layers are visible: the inner (core) is gray or gray with a creamy tint and the outer is white or white with a creamy tint.

1 tablet contains:

active substance: ethylmethylhydroxypyridine succinate 125 mg.
Excipients: lactose monohydrate 97.5 mg; povidone 25 mg; magnesium stearate 2.5 mg
film sheath: Opadry II white - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

Packing: Tablets 0.125 g in blisters, cardboard pack.

Injection

Mexidol in ampoules of 2 or 5 ml. - the solution is colorless or slightly yellowish, transparent. Solution for intravenous and intramuscular administration, 50 mg/ml.

1 ml solution contains: active substance- ethylmethylhydroxypyridine succinate 50 mg., excipient- water for injection.

Package: 1 or 2 blisters are placed in a pack of cardboard; 4, 10 or 20 blister packs are placed in a pack of box cardboard.

Indications for use

Mexidol is proposed for the treatment of acute disorders of cerebral circulation, dyscirculatory encephalopathy (a disease of the brain caused by a chronic violation of cerebral circulation), vegetovascular dystonia (impaired vascular tone due to dysfunction of the autonomic nervous system), atherosclerotic disorders of the brain, for the relief of withdrawal symptoms (to relieve the condition resulting from a sudden cessation of taking drugs or alcohol) in alcoholism and drug addiction, in other conditions accompanied by tissue hypoxia.

• acute violation of cerebral circulation;
• encephalopathy;
• cardiopsychoneurosis;
• mild cognitive disorders of atherosclerotic genesis;
• neurotic and neurosis-like states with anxiety syndrome;
• relief of withdrawal symptoms in alcoholism with the presence of neurotic and vegetative-vascular disorders in the clinical picture;
• acute intoxication with antipsychotics (neuroleptics);
• acute purulent-inflammatory processes of the abdominal cavity (acute pancreatitis, peritonitis) as part of complex therapy.

Pharmacodynamics

The drug has an antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. Mexidol increases the body's resistance to various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotic drugs).

Mexidol improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL. Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action of Mexidol is due to its antihypoxant, antioxidant and membrane-protective action. It inhibits the processes of lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. It modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission.

Mexidol increases the content of dopamine in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

Pharmacokinetics

Rapidly absorbed when taken orally. When taken orally in doses of 400-500 mg C max is 3.5-4 μg / ml. It is rapidly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9-5.2 hours.

Metabolized in the liver by glucuronconjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and with the participation ALP breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in the urine for 1-2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th - glucuronconjugates.

T 1/2 when taken orally - 2-2.6 hours. Rapidly excreted in the urine, mainly in the form of metabolites and in small quantities unchanged. Most intensively excreted during the first 4 hours after taking the drug. Urinary excretion rates of unchanged drug and metabolites are subject to individual variability.

Dosing regimen

Tablets Mexidol

Inside, 125-250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).

Duration of treatment - 2-6 week; for the relief of alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose within 2-3 days.

The initial dose is 125-250 mg (table 1-2) 1-2 times a day with a gradual increase until a therapeutic effect is obtained; the maximum daily dose is 800 mg (6 tablets).

The duration of the course of therapy in patients IHD - at least 1.5-2 months. Repeated courses (on the recommendation of a doctor), it is desirable to conduct in the spring and autumn periods.

Injection

Mexidol is prescribed intramuscularly or intravenously (stream or drip). With the infusion method of administration, the drug should be diluted in an isotonic sodium chloride solution. Doses are selected individually. The recommended dose is 5-10 mg/kg per day, depending on the condition. Jet Mexidol is injected slowly over 5-7 minutes, drip - at a rate of 40-60 drops / min.

During treatment acute cerebrovascular accident Mexidol is used as part of complex therapy by intravenous drip at a dose of 200-300 mg 2 times / day for the first 5-7 days, then IM at 200-300 mg 2 times / day. The duration of treatment is 10-14 days.

At dyscirculatory encephalopathy in the phase of decompensation Mexidol should be administered in / in a stream or drip at a dose of 200 mg 2-3 times / day for 14 days. Then the drug is administered intramuscularly at 200-300 mg / day for the next 2 weeks.

For course prevention of dyscirculatory encephalopathy the drug is administered intramuscularly (injections) at a dose of 200 mg 1-2 times / day for 10-14 days.

At mild cognitive impairment of atherosclerotic origin in elderly patients and neurotic disorders with anxiety syndrome Mexidol is prescribed intramuscularly (injections) at a dose of 100-300 mg / day for 14-30 days.

At alcohol withdrawal syndrome Mexidol is administered at a dose of 200-300 mg / m (injections) 2 times / day or in / in the drip 1-2 times / day for 5-7 days.

At acute intoxication with antipsychotic drugs the drug is administered intravenously at a dose of 200-600 mg / day (up to 800 mg) for 7-14 days.

At acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) Mexidol is prescribed on the first day both in the preoperative and postoperative period. The dose of the drug depends on the form and severity of the disease, the prevalence of the process, and the variants of the clinical course. Cancellation of the drug should be carried out gradually, only after a stable positive clinical and laboratory effect.

• At acute edematous (interstitial) pancreatitis Mexidol is prescribed 200-600 mg 2-3 times / day in / in the drip and / m.
• At mild necrotizing pancreatitis the drug is prescribed 200-400 mg 2-3 times / day in / in the drip and / m;
• at moderate necrotizing pancreatitis- 200-600 mg 2-3 times / day in / in drip;
• with a difficult course of the process- on the first day, it is prescribed in a pulse dose of 800 mg, divided into two injections, then 300 mg 2 times / day with a gradual decrease in the daily dose;
• with extremely severe course of necrotizing pancreatitis- the initial dose is 800 mg / day until persistent relief of manifestations of pancreatogenic shock, with stabilization of the condition - 300-400 mg 2 times / day in / in drip with a gradual decrease in the daily dose.

Mexidol for children

The use of Mexidol in pediatrics is indicated for the treatment of purulent neuroinfections, craniocerebral injuries, as well as for first aid in case of childhood craniocerebral injuries (100 mg once).

For children, the drug should be prescribed by a doctor who will monitor the child all the time of its use. There are no statistically significant studies of the use of the drug in children. Local application in dental practice passes without complications.

Side effect

From the digestive system: rarely - nausea, dry mouth.
Rarely- allergic reactions.

Contraindications

• acute liver dysfunction;
• acute renal dysfunction;
• hypersensitivity to the drug.

Pregnancy and lactation

Mexidol is contraindicated during pregnancy and lactation (breastfeeding) due to insufficient knowledge of the drug.

special instructions

Patients with blood pressure more than 180/100 mm Hg, a crisis course of arterial hypertension and severe affective instability require careful monitoring of blood pressure during therapy with Mexidol.
The inclusion of Mexidol in complex therapy in patients with acute cerebrovascular accident contributed to an increase in resistance to hypoxia and a decrease in the severity of manifestations of clinical syndromes of stroke.

The use of Mexidol in the complex treatment of acute pancreatitis significantly reduces the level of enzymatic toxemia and endogenous intoxication.

The high efficiency of Mexidol in the combined route of administration for monotherapy of reactive arthritis has been shown.

Overdose

Due to the low toxicity of Mexidol, an overdose is unlikely, and so far no such cases have been reported.

Perhaps the development of drowsiness.

drug interaction

With the simultaneous use of Mexidol enhances the action of anxiolytics, benzodiazepine derivatives, antiparkinsonian and anticonvulsants.

Mexidol reduces the toxic effects of ethyl alcohol.

Mexidol price

Prices are approximate for November 2017, because differ in different pharmacies and cities.

Mexidol reviews

I drank Mexidol, and my effect was just wonderful, right before my eyes I came out of a state of hysteria. And saw pills and injections. And I am also picky, not every drug worked for me, and sometimes even a paradoxical effect, but maxidol was without side effects and very effective.

I was injected with Mexidol. The reason was cerebrovascular insufficiency. The effect was amazing. Immediately brightened in the eyes, began to hear better, cleared up in the head, the mood, however, somehow strangely rose. But I clearly remember that this drug was sold on a separate special prescription with a special seal. So, it is better to give it the way the doctor prescribed, so that the effect is not too strong.

Excellent pills for a swollen nervous system. Of the tablets, the best that came across from dystonia. Helps? Definitely! All the symptoms of VVD I personally slept. But, after a course of treatment, most of the symptoms will return. Both the cardiologist and the neurologist were praised; tablets are quite versatile. Sold officially by prescription, but almost everywhere they sell without it. I ate pills, I think injections will be much better.

I understood from the reviews that Mexidol will help with disturbed vegetative, and with obsessive thoughts and conditions, does it help to fight or is it completely different? It did not help me, but I drank 1 tablet a day only. If you follow the recommended dosage, it may help. In general, obsessive thoughts, as I understand it, is again my "favorite" anxiety. Afobazole helps with it, 2 tablets a day are enough for me.

Registration number: R N002161/01 - 171016
Trade name of the drug: Mexidol®
Group name: Ethylmethylhydroxypyridine succinate.
Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.
Dosage form solution for intravenous and intramuscular administration

Compound:
Active substance: Ethylmethylhydroxypyridine succinate 50mg
Excipients:
Sodium metabisulphite - 0.4 mg
Water for injection up to 1 ml

Description:
Colorless or slightly yellowish transparent liquid in ampoules of 2 or 5 ml

Pharmacotherapeutic group: Antioxidant
ATS: NO7XX
Means for the correction of disorders in alcoholism, toxic and drug addictions.

Pharmacological properties:

Pharmacodynamics:
It has antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effects, increases the body's resistance to stress. The drug increases the body's resistance to the effects of major damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, intoxication with alcohol and antipsychotic drugs (neuroleptics)).
Mexidol ® improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the level of total cholesterol and LDL.
Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.
The mechanism of action of Mexidol ® is due to its antihypoxant, antioxidant and membrane-protective action. It inhibits the processes of lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and increases its fluidity. It modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to maintain the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexidol ® increases the content of dopamine in the brain. It causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in the content of ATP, creatine phosphate and activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes. Mexidol ® normalizes metabolic processes in the ischemic myocardium, reduces the area of ​​necrosis, restores and improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the area of ​​ischemia, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. Increases antianginal activity of nitropreparations. Mexidol ® contributes to the preservation of retinal ganglion cells and optic nerve fibers in progressive neuropathy, the causes of which are chronic ischemia and hypoxia. Improves the functional activity of the retina and optic nerve, increasing visual acuity.

Pharmacokinetics: When administered intramuscularly, it is determined in the blood plasma for 4 hours after administration. The time to reach the maximum concentration Tmax is 0.45-0.5 hours. Cmax with a dose of 400-500 mg is 3.5-4.0 μg / ml. Mexidol quickly passes from the bloodstream to organs and tissues and is quickly eliminated from the body. The drug retention time (MRT) is 0.7-1.3 hours. The drug is excreted mainly in the urine, mainly in the glucuronoconjugated form and in small quantities unchanged.

Indications for use:

Acute disorders of cerebral circulation;
- encephalopathy;
- syndrome of vegetative dystonia;
- mild cognitive disorders of atherosclerotic genesis;
- anxiety disorders in neurotic and neurosis-like states;
- acute myocardial infarction (from the first day) as part of complex therapy;
- primary open-angle glaucoma of various stages, as part of complex therapy;
- relief of withdrawal symptoms in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
- acute intoxication with antipsychotic drugs;
- acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) as part of complex therapy.

Contraindications:

Acute disorders of the liver and kidneys, increased individual sensitivity to the drug. Strictly controlled clinical studies of the safety of Mexidol in children, during pregnancy and lactation have not been conducted.

Method of application and dose. V / m or / in (stream or drip). With the infusion method of administration, the drug should be diluted in an isotonic sodium chloride solution.
Jet Mexidol is injected slowly over 5-7 minutes, drip - at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 1200 mg.
In acute disorders of cerebral circulation mexidol is used in the first 10-14 days - intravenously, 200-500 mg 2-4 times a day, then - intramuscularly, 200-250 mg 2-3 times a day for 2 weeks.
With dyscirculatory encephalopathy in the phase of decompensation, mexidol should be administered intravenously by stream or drip at a dose of 200-500 mg 1-2 times a day for 14 days. Then - in / m at 100-250 mg / day for the next 2 weeks.
For course prevention of dyscirculatory encephalopathy the drug is administered intramuscularly at a dose of 200-250 mg 2 times a day for 10-14 days.
For mild cognitive impairment in elderly patients and with anxiety disorders, the drug is used intramuscularly at a daily dose of 100-300 mg / day for 14-30 days.
In acute myocardial infarction as part of complex therapy Mexidol ® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic agents according to indications.
In the first 5 days, to achieve the maximum effect, it is desirable to administer the drug intravenously, in the next 9 days Mexidol ® can be administered intramuscularly. % solution of dextrose (glucose) in a volume of 100 - 150 ml for 30-90 minutes. If necessary, slow jet administration of the drug is possible, lasting at least 5 minutes.
The introduction of the drug (intravenous or intramuscular) is carried out 3 times a day, every 8 hours. The daily therapeutic dose is 6-9 mg/kg of body weight per day, a single dose is 2-3 mg/kg of body weight. The maximum daily dose should not exceed 800 mg, single - 250 mg.
In case of open-angle glaucoma of various stages, as part of complex therapy, Mexidol ® is administered intramuscularly at 100-300 mg / day, 1-3 times a day for 14 days.
With alcohol withdrawal syndrome Mexidol is administered at a dose of 200-500 mg intravenously by drip or intramuscular injection 2-3 times a day for 5-7 days.
In acute intoxication with antipsychotics the drug is administered intravenously at a dose of 200-500 mg / day for 7-14 days.
In acute purulent-inflammatory processes of the abdominal cavity(acute necrotizing pancreatitis, peritonitis) the drug is prescribed on the first day both in the preoperative and postoperative period. The administered doses depend on the form and severity of the disease, the prevalence of the process, and the variants of the clinical course. Cancellation of the drug should be made gradually only after a stable positive clinical and laboratory effect.
Acute edematous (interstitial) pancreatitis Mexidol is prescribed 200-500 mg 3 times a day, intravenously (in isotonic sodium chloride solution) and intramuscularly. Mild severity of necrotizing pancreatitis- 100-200 mg 3 times a day intravenously (in isotonic sodium chloride solution) and intramuscularly. Moderate severity- 200 mg 3 times a day, intravenously (in isotonic sodium chloride solution). Severe course- in a pulse dosage of 800 mg on the first day, with a double regimen of administration; further - 200-500 mg 2 times a day with a gradual decrease in the daily dose. Extremely severe course- at an initial dosage of 800 mg / day until persistent relief of manifestations of pancreatogenic shock, after stabilization of the condition - 300-500 mg 2 times a day intravenously (in isotonic sodium chloride solution) with a gradual decrease in daily dosage.

Side effects. Perhaps the appearance of nausea and dryness of the oral mucosa, drowsiness, allergic reactions.

Interaction. Enhances the action of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), antiparkinsonian drugs (levodopa). Reduces the toxic effects of ethyl alcohol.

Special instructions:

In some cases, especially in predisposed patients with bronchial asthma with increased sensitivity to sulfites, severe hypersensitivity reactions may develop.

Modern medicine uses many drugs with antihypoxic, anxiolytic, membrane-stabilizing, nootropic, anticonvulsant effects. This is due to the peculiarities of the course of diseases with frequent damaging effects of etiological factors on blood vessels, including those of the brain. One of these drugs is mexidol. It is a drug that has pharmacological action on at least two levels- cellular and vascular (including neurons and vessels of the brain).

According to the instructions, its use is indicated for conditions such as shock, alcohol intoxication, cerebrovascular accident, hypoxic conditions (for example, with craniocerebral injuries occurring with concussion phenomena), ischemia (for example, in the elderly with changes in the walls of blood vessels, including cerebral vessels) with a stroke or heart attack clinic, vegetovascular dystonia, encephalopathy, mild cognitive and intellectual-mnestic disorders, especially in the elderly. It has been clinically proven effective action of mexidol in the treatment of glaucoma, contributing to the suspension of the course of the disease (complete recovery from glaucoma is impossible).

Given the wide spectrum of action of the drug Mexidol, its use in the complex treatment of inflammatory surgical diseases of the abdominal cavity(edematous and necrotic forms of pancreatitis, peritonitis) is more than justified.

Mexidol is used in dentistry in the form of applications. and rinsing with an injection solution of the oral cavity. The use of Mexidol toothpaste in several of its varieties determines a wide range of properties of oral hygiene products: anti-inflammatory, prophylactic, hemostatic, whitening.

Forms of release of the drug Mexidol. injection form

Mexidol is available as:

1. ampoules for intramuscular / intravenous use;
2. tablets.

At the beginning of the disease, the drug can be used in the form of injections. The form of release of the drug does not affect the mechanism of its action, i.e., regardless of the form of the drug, all the properties of the drug are preserved.

Mexidol solution is a transparent colorless or light yellow liquid in colorless or light-protected glass ampoules, on which a blue or white break point and three marking rings are located, the top one is yellow, the middle one is white, the bottom one is red. The capacity of the ampoules is 2 or 5 ml. The drug is available as a 5% solution (this means the content of 50 mg of the active substance in 1 ml of the solution) in a blister pack of 5 ampoules; in a carton box 2 blisters.

Ampoules can be used:

1. for intravenous administration (in this case, 0.9% sodium chloride solution is used as a solvent);
2. for intramuscular injection.

Intravenously, the drug can be administered both by jet and drip. The rate of its introduction with drip infusion is 60 drops per minute. The time of jet administration of the drug is 5-7 minutes. We will consider the intramuscular use of Mexidol in more detail, since in practice it is often necessary to carry out this injection outside the walls of a medical institution.

Before performing any injection, it is important to make sure:

1. in the correct choice of the drug (check the prescribed and used drugs);
2. in compliance with the expiration date of both the drug used and the syringe;
3. the ampoule, syringe and their packaging are safe.

Injections (injections) require obligatory observance of asepsis. Before starting work, wash your hands with soap and water, carefully treat them with alcohol, put on gloves. After carrying out all these activities, it is necessary to open the ampoule, draw the solution into a syringe and perform an injection.

How to open ampoules with mexidol? First you need to knock on the ampoule so that the drug completely sinks to the bottom of the ampoule. Then, having treated the ampoule with an alcohol solution, you need to wrap the break point area with a napkin and gently press<<от себя>>.

After opening the ampoule, draw the solution into the syringe, for which the needle section is immersed in the solution completely and pull the piston “towards you.” Then, holding the syringe vertically with the needle up, tap it with your finger, collect all the small air bubbles into one and, gently pressing on the piston , remove air. Put the cap on the needle.

The injection should be performed in the position of the patient<<лёжа>>, which ensures maximum muscle relaxation and, accordingly, a less painful procedure for administering the drug. The intramuscular injection site is usually the upper outer quadrant of the buttock. It is treated with an alcohol solution twice: first, an area up to 10 cm in diameter from top to bottom, then, after 10-15 seconds, an area up to 5 cm in diameter. After 10-15 seconds, when the injection field dries, an injection is made, after changing the needle to syringe. The needle cannula is held with the little finger, and the syringe barrel with the other fingers.

The injection is done quickly and sharply to cause the least pain. The needle must be inserted 2/3 of its length. The drug solution must be administered slowly so that infiltrates do not form, which will then slowly dissolve, causing pain to the patient. Before removing the needle from the buttock, it is necessary to clamp the injection site with a sterile napkin and quickly remove the needle. The prick is done.

Mexidol tablets

Other the form of the drug - mexidol tablets - is presented in the form of biconvex tablets, covered with a shell of white or slightly cream color. Two layers are visible on the cut: the inner one is gray, the outer one is white. One tablet contains 125 mg of active ingredient. The drug is available in blisters of 10 tablets each (3-5 blisters per package) or in plastic jars of 90 tablets. For hospitals, the drug is sold in plastic containers of 450 or 900 tablets. Tablets are taken after meals and washed down with a small amount of water.

Considering the presence of two forms of the drug, the question is natural: "Which of these two forms is better to take?" It would be more correct to talk about the expediency of using the drug in certain cases. Of course, the use of Mexidol solution is indicated for a more severe course of the disease, the need to administer the drug intravenously / intramuscularly, the inability of the patient to take pills.

Mexidol solution is determined in the blood plasma after 0.45 - 0.5 hours. The average retention time of the active substance in the blood plasma is from 0.7 to 1.3 hours, according to some reports, up to 4 hours. When using the tablet form of Mexidol, the drug is found in the body up to 5 hours. Biotransformation of the Mexidol solution is carried out in the liver. The drug is excreted by the kidneys. These about characteristics of the drug and determine the possibility of its use.

Contraindications to the use of mexidol

We have already mentioned the indications for the use of the drug Mexidol. Now it is advisable to discuss the issue of contraindications to the use of this drug. According to the instructions for use of the medication, a categorical contraindication is individual intolerance to the drug, impaired liver function and impaired renal function. Like any other medication, mexidol can cause allergic reactions. Their appearance during the treatment period is a contraindication to the further use of this drug.

In addition, pharmacological firms have not conducted clinical studies on the safety of Mexidol in children, during pregnancy and lactation. And this means that there is a certain risk of using this drug in patients of these groups. Nevertheless, is it possible to use mexidol in this category of patients? If the state of health of a sick nursing mother requires the appointment of mexidol, then it can be used with the simultaneous cessation of breastfeeding. The literature also describes the use of mexidol in children.

Patients with certain diseases of the blood system (for example, hemophilia) cannot use mexidol in the form of intramuscular injections. It makes sense to specify one more point: if the drug is not taken urgently, then the presence of inflammatory skin diseases at the sites of possible injections also requires caution in the use of the injectable form of mexidol.

Despite the good tolerability of the drug in many cases, side effects such as nausea, dryness of the oral mucosa can sometimes be observed. After its cancellation, these symptoms stop on their own. According to the instructions, people suffering from bronchial asthma may develop a severe allergic reaction. For people with arterial hypertension, especially those with a crisis course, it is better not to prescribe Mexidol until the pressure normalizes. Caution is needed in its appointment to persons whose work is related to vehicles or complex mechanisms, which requires increased concentration of attention.

The effectiveness of the drug Mexidol

The patient is often interested in the question: when does the action of mexidol come on? Mexidol begins to act quickly, on average from 2 to 7 days. Its dose is determined by the attending physician, according to the instructions. The initial doses of mexidol depend on the disease. Timely initiation of therapy with low doses with the selection of the optimal dose is important. Cancellation of the drug should be gradual. So, the therapeutic effect of mexidol is wide, which is described in detail in the instructions for use of the drug. Repeated courses of treatment are advisable. When? As a rule, and x can be used in the spring and autumn periods. The course use of Mexidol improves cognitive functions, helps to restore the body.