Premature aging is the name of the disease. Why do women live longer? Who is at risk

Aging of the whole organism is a natural and inevitable process programmed by nature, which is one of the main problems of biology and medical science generally.

Although the changes appearance are natural, physiological, but the timing of their appearance depends on many causative factors- genetic, hereditary, age. The latter are determined by the influence of the aging organism on all organs and tissues, including the skin. What are the causes and how to prevent premature skin aging.

Causes of premature skin aging

To external manifestations pathological wilt include:

• thinning and, a decrease in the thickness of the subcutaneous fat layer;
• dryness, itching and peeling of the epithelium of the stratum corneum;
• discoloration of the skin of the face;
• decreased skin turgor and gravitational tissue ptosis;
• early appearance of wrinkles, folds on the face;
• vascular changes in the form of expansion of superficial vessels (), the appearance of vascular "nets" and "asterisks";
• premature aging of the skin of the hands;
• early and.

These phenomena begin to appear from the age of 25, and in the presence of adverse factors, sometimes even earlier. With increasing age, they increase more and more. Pathological, or premature, aging is accompanied by changes in internal organs and tissues and is characterized by a higher, compared with people of the same age category, the rate of appearance of changes in the appearance of a person. In these cases we are talking about advancing, exceeding biological age, in comparison with passport data.

Inextricable withering of the skin is associated with changes throughout the body. Accordingly, the factors causing early aging skin, basically the same ones that accelerate the appearance and age-related changes in the body. Thus, the rate of development of age-related changes skin Numerous unfavorable, so-called "everyday" factors constantly or periodically influence:

1. Internal, or endogenous.
2. External, or exogenous.
3. A combination of internal and external factors.

Endogenous negative factors

They are mainly associated with a weakening of general immunity and a violation of the blood levels of sex hormones, in particular estrogens, in women. In addition, for the development of premature aging, the inadequate functioning of the nervous, endocrine, microcirculatory systems, organs of the excretory and respiratory systems. All of them provide the skin with the ability to maintain biochemical processes, temperature and barrier functions, and local immunity at the required level.

Therefore, the most frequent illnesses leading to early aging of the skin is a pathology of the endocrine system, especially diabetes mellitus, reduced function thyroid gland, hypothalamic-pituitary syndrome, diseases of the endocrine glands of the genital organs, coronary heart disease and cardiovascular failure, chronic pulmonary pathology, decrease in the degree of general immune protection, which leads to a decrease in local immunity, autoimmune diseases connective tissue.

Of no small importance are also the pathology of the liver and biliary system, diseases of the digestive tract and urinary system, violations metabolic processes in the body. Features of premature wilting in men are associated, in addition to the above, mainly with a decrease (according to various reasons) blood levels of male sex hormones, since they have a stimulating effect on the sebaceous and sweat glands.

It is quite natural that the full supply of the skin with oxygen, vitamins, microelements, hormones, etc., of course, depends on the content of these components in the body, but one should not underestimate their supply to the cells through the blood and lymph microcirculation system, as well as the role of these mechanisms in removal of decay products and processes of cellular regeneration.

Exogenous factors

These include mainly:

• Unfavorable environmental conditions (from 40 to 60%), in which the ambient air contains significant concentrations of chemical compounds harmful to the body;
• Overexposure ultraviolet irradiation on unprotected skin sunscreens, as well as the neglect of the use of "after-sun" creams that help neutralize the effects of solar radiation;
• Insufficient or, conversely, excessive moisture environment;
• Irrational nutrition, overweight body and lack of physical activity;
• Frequent stressful conditions and prolonged psycho-emotional stress;
• Abuse alcoholic drinks, as well as smoking, in which chronic nicotine intoxication, spasmodic small peripheral vessels, leads to disturbances in blood microcirculation and to a deterioration in the delivery of oxygen to tissues and nutrients. In addition, some chemical compounds contained in tobacco destroy proteins, which include metal atoms (metal proteins) involved in the synthesis of skin and elastin, resulting in a decrease in skin elasticity with intense formation of wrinkles;
• Food colorings and preservatives and components of certain cosmetics, as well as means household chemicals contributing to allergic and inflammatory reactions;
• Level social status, including biological and psychological needs and social opportunities to satisfy them.

Basic Mechanisms

The mechanisms of pathological aging are specific physiological and biochemical processes through which the impact on the human body of negative endogenous and exogenous factors is realized. Among the various mechanisms at present, the main importance is given to the so-called free radical reactions, which result in the formation of free radicals and aggressively active oxygen forms.

Free radicals are "fragments" of molecules with missing electrons. Their reactive activity is due to the ability to attach electrons to themselves from other molecules. Such a biochemical reaction is necessary to ensure the flow of normal metabolic processes in the body. Under normal physiological conditions, the amount of free radical molecules is strictly controlled by the body.

However, under the influence negative factors, especially chemical compounds of the environment and ultraviolet rays, an excess amount and accumulation of free radicals are formed. They lead to the destruction of the cell membrane, cellular lipids, proteins, mitochondria and DNA. The consequence of this influence is premature cell death, the predominance of degenerative processes over cellular regeneration, accelerated degradation and disruption of the synthesis of collagen and elastin proteins. All these phenomena are united by the name "oxidative stress".

Collagen and elastin fibers play a particularly important role in the condition of the skin, giving it a state of strength, firmness and elasticity. With age, there is a gradual decrease in their volume and quantity. But under the influence of accumulated free radicals, there are, which is especially important, significant changes in their structure and physical and chemical properties, due to which skin firmness and elasticity decrease, wrinkles and folds form, tissues of the face and other parts of the body appear.

Another significant mechanism is a decrease in the saturation of the skin with water molecules and the destruction of its epidermal layer as a barrier. The result is an increased vulnerability of the skin to the influence of bacterial, physical and chemical factors.

So, summing up the section, it is necessary to highlight the main mechanisms and manifestations of aging. The first ones include:

1. Deceleration of cellular renewal.
2. Quantitative reduction and structural and qualitative violation of collagen and elastin proteins.
3. Disorder of microcirculation in tissues and increased permeability vascular wall leading to skin dehydration and swelling of the intercellular tissue.
4. Destruction of the epidermal barrier.
5. Accumulation of metabolic products.

How can early destructive processes be prevented?

Despite a certain “autonomy” of the skin, their successful functioning cannot but depend on the state of the whole organism or its individual systems, and it is impossible to slow down the processes of early skin aging by using only cosmetics and preparations.

Since modern medicine does not have enough ways to influence the genetic and age factors of aging, the main efforts of it and cosmetology are aimed at eliminating or limiting the influence of "everyday factors". Identification of the causes makes it possible to prevent aging or at least slow down the pace of its development. For these purposes, it is necessary:

• prevention of stressful situations and psycho-emotional disorders and increasing resistance to their effects;
• balanced diet, correct mode work and rest, sleep normalization;
• quitting smoking and alcohol abuse;
• treatment of diseases or correction of the functioning of internal organs with drugs and other means;
• correction of the general immune state and local immunity;
• increasing the possibilities of regulating the body by adaptive mechanisms (improving metabolism, normalizing hormonal background, acceleration of the elimination of toxins and toxins from the body, etc.);
• proper and regular skin care with anti-aging cosmetics.

of great importance in the fight against oxidative stress has acquired an increased use and external use of natural antioxidants that can block free radical oxidative reactions, as well as their use in cosmetology and medicine in the form of drugs.

How to avoid premature skin aging?

Aging is not a disease, but a state of the body, which is due to heredity and age characteristics. At present, medicine and modern cosmetology have very little ability to influence genetic and age reasons aging.

At the same time, premature wilting is the object of their attention. Therefore, their main tasks are to eliminate the "everyday" causal factors and early manifestations wilting, as well as in the correct application of anti-aging therapies. This can be largely influenced by the person himself, who is informed about the causes of early withering of the skin.

In October 2005, in a Moscow clinic, doctors performed the first operation on a patient suffering from premature aging syndrome. Progeria is very rare disease. Medical luminaries around the world claim that from the moment of "awakening" in the body of this disease, people live on average only 13 years.

According to statistics, about 1 in 4 million people are born with a similar genetic defect. Progeria is divided into children's, called Hutchinson-Gilford syndrome, and adult progeria, Werner's syndrome. In both cases, the genetic mechanism breaks down and unnatural depletion of all life support systems begins. With the Hutchinson-Gilford syndrome, the physical development of children is delayed while the signs of senile graying, baldness, and wrinkles appear in them in the very first months of life.

By the age of five, such a child suffers from all senile ailments: hearing loss, arthritis, atherosclerosis, and does not even live to be 13 years old. With Werner's syndrome, young people begin to age rapidly at the age of 16-20 years, and by the age of 30-40 such patients die with all the symptoms of old age.

There is no cure for progeria - using all the scientific achievements, you can only slow down the irreversible process.

Cases of sudden aging are very prosaic: living in normal conditions the child at first surprises those around him with his rapid development. At a young age, he looks like an adult, and then he begins to show all the signs of ... approaching old age.

In 1716, the eighteen-year-old son of Earl William of Sheffield died in the English city of Nottingham, who began to grow old at the age of thirteen. Young Sheffield looked much older than his father: gray hair, half-fallen teeth, wrinkled skin. The unfortunate young man had the appearance of a man battered by life, he suffered greatly from this and accepted death as deliverance from torment.

There are cases of this kind among representatives of royal families. The Hungarian king Ludwig II had already reached puberty at the age of nine and was happy to have fun with the court girls. At fourteen, he acquired a thick full beard and began to look at least 35 years old. A year later, he married, and by the age of sixteen, his wife gave him a son. But at the age of eighteen, Ludwig completely turned gray, and two years later he died with all signs of senile decrepitude.

It is curious that neither the king's son nor his further descendants inherited such a disease. From examples of the 19th century, one can single out the story of a simple village girl, the Frenchwoman Louise Ravaillac. At the age of eight, Louise, fully formed as a woman, became pregnant by a local shepherd and gave birth completely healthy child. By the age of sixteen, she already had three children and she looked older than her mother, at 25 she turned into a decrepit old woman and, before reaching 26, she died of old age.

Of no less interest are the fates of those who lived in the 20th century. Some of them are more fortunate than others. For example, born in 1905, a resident of the American city of San Bernardino, Michael Sommers, who matured early and aged, was able to live to be 31 years old. At first, a super-fast entry into adult life even made him happy. But when, at seventeen, Michael realized with horror that he had begun to age, he began to make desperate attempts to stop this destructive process.

But the doctors just shrugged, unable to do anything to help. Sommers managed to slow down the decrepitude a little after he, having moved to a permanent residence in the village, began to spend a lot of time outdoors. But still, by the age of 30, he turned into an old man, and a year later he was finished off by an ordinary flu. Among other similar phenomena, one can single out the Englishwoman Barbara Dalyn, who died in 1982 at the age of 26.

By the age of 20, having managed to be married and give birth to two children, Barbara quickly and irreversibly grew old. That is why her young husband left her, who did not want to live with the "old ruin". At the age of 22, from deteriorating health and suffering shocks, the “old woman” became blind and, until her death, moved by touch or accompanied by a guide dog, presented to her by the authorities of her native Birmingham.

Paul Demongeot from the French city of Marseille is twenty-three years old. At the same time, he looks at all 60 and feels like a man of advanced age. However, he does not yet lose hope that a miracle will happen and a remedy will be found that will stop his rapid decrepitude. His brother in misfortune, Sicilian from the city of Syracuse, Mario Termini, is not even 20 years old, but he looks much more than 30. The son of wealthy parents, Termini does not deny himself anything, meets local beauties and leads a wild life.

What do we have?

"Early" people lived in our country. Back in the days of Ivan the Terrible, the son of the Mikhailov boyars, Vasily, died at the age of 19 as a decrepit old man. In 1968, at the age of 22, Nikolai Shorikov, a worker at one of the factories, died in Sverdlovsk. He began to grow old at the age of sixteen, which extremely puzzled the doctors. The luminaries of medicine only shrugged their shoulders: “This cannot be!”

Having become an old man at the age when everything was just beginning, Nikolai lost all interest in life and committed suicide by swallowing pills ... And thirteen years later, 28-year-old "old man" Sergei Efimov died in Leningrad. His youthful period ended by the age of eleven, and he began to noticeably age after twenty and died a decrepit old man, having almost completely lost the ability to think sensibly a year before his death.

Genes are to blame

Many scientists believe that the main cause of this disease is a genetic mutation leading to the accumulation a large number protein in cells. Psychics and magicians claim that there are special methods of sending "damage" in order to age a person.

By the way, this disease occurs not only in humans, but also in animals. They also have life cycles and periods sometimes go according to the scenario for three or even ten years. Perhaps the solution to the problem will be found after many years of experiments on our smaller brothers.

A drug called a farnesyl transferase inhibitor significantly reduces the rate of symptoms of premature aging in lab mice, researchers at the University of California have found. Perhaps this medicine will be suitable for the treatment of people.

Here is how the candidate of biological sciences Igor Bykov characterizes the symptoms of the disease in children: “Progeria occurs suddenly with the appearance of large age spots on the body. Then people begin to be overcome by the most real senile ailments. They develop diseases of the heart, blood vessels, diabetes, hair and teeth fall out, disappears subcutaneous fat. Bones become brittle, skin wrinkled, and bodies hunched over. The aging process in such patients proceeds approximately ten times faster than in healthy person. Evil is rooted, most likely, in the genes. There is a hypothesis that they suddenly stop giving the cells the command to divide. And those quickly become worthless.

The genes stop giving the cells the command to divide, as it were, because the ends of the DNA in the chromosomes are shortened - the so-called telomeres, the length of which is supposedly the length of a human life. Similar processes are taking place in normal people, but much slower. But it is completely incomprehensible, as a result of what kind of violation, telomeres are shortened and aging begins to accelerate at least 10 times. Now scientists are trying to lengthen telomeres with the help of enzymes. There were even reports that American geneticists managed to prolong the life of flies in this way. But the results applicable in practice are still far away. People cannot be helped even at the level of experiments. Fortunately, the disease is not inherited.

It is assumed that a failure in the genome occurs even during the period prenatal development. So far, science cannot track and manage this failure: it can only state a fact, but perhaps in the near future gerontology will answer this question to the world.

Years pass and sooner or later a person looks in the mirror and notices that his face has changed. Getting up in the morning is no longer so pleasant and at every opportunity you want to lie down to lie down. Thinking that the body is getting old brings little joy. Why does this always happen earlier than expected and what can be done to stop the process of withering your life?

What does premature aging mean?

Human chromosomes have regions called telomeres at their ends. They have a certain length and each time a cell divides, this length is shortened. When a cell goes through all the cycles of division, it completely loses its telomere. Throughout life, a person loses telomeres and cells remain in his body, deprived of the possibility of division. This shows signs of aging.

The aging of the body occurs unevenly. Some systems age faster than others. Skin ages faster than anyone else. The reason for this is frequent update cycles. The skin is renewed every month. Therefore, skin cells are the fastest to lose their telomeres. Women's breasts also ages faster than the rest of the body. She is older by 2-3 years. This is due to the dependence of its tissues on the hormonal background. The cardiovascular system is the youngest. He lags behind in aging from the whole organism by 10 years. The reason for this is not known.

The aging process depends on genetic predisposition. If in the human family all relatives were long-lived and remained young for a long time, it means that the genetic program of slow aging is observed in the family.

The genetic factor and the role of telomeres are not the only causes of aging. When a person shows the first signs of aging already at the age of 20, it means that he has begun premature aging of the body, due to various external and internal factors. This happens from excessive wear and tear of the body due to diseases, lifestyle, mental background.

Signs of premature aging

1. excessive fatigue;
2. early wrinkles;
3. change in the oval of the face;
4. hair loss;
5. muscle atrophy.

What affects the process?

By understanding more fully what affects premature aging, steps can be taken to either stop it or slow it down.

The environmental conditions in which a person lives play an important role. The air he breathes. The water with which he bathes and drinks. The origin of foodstuffs, such as the geographical origin of meat, vegetables and fruits. For example, people who live in areas near mountains or the sea age more slowly. They breathe fresh air, drink clean water, eat foods grown in the same favorable conditions.

Direct sunlight has an effect on skin aging also known as photo-aging. It can be seen that people who fanatically sunbathe in the sun already very early have dry, wrinkled skin.

smoking, alcohol, toxic substances significantly wear out the body. They force the body to get rid of poisons in an intensive mode, leading to an accelerated consumption of the body's health resources. Alcohol, even minimum doses(1 glass of wine), disrupts the functioning of the body, stresses the liver, blood vessels and kidneys. Regular use of cognac, wine, supposedly for relaxation, causes regular harm to the body, accelerating the aging process.

Avitaminosis, lack of vitamins and minerals, in the body inevitably depletes the body, causing it to starve, preventing it from regenerating normally.

The pace of life and stress plays a role in aging, exhausting the body. The intensive pace of life introduces the body into a state of constant stress, disruption of homeostasis. The body wears out faster than expected. Emotional instability also works.

Prolonged sitting slows down blood and lymph circulation, changes DNA, starting the process of wear and tear. As a result, early diseases of varicose veins, tension headaches, swelling, muscle atrophy.

Lack of estrogen in women leads to early aging, but its excess is also undesirable.

Skin lightening with the help of cosmetics, leads to photoaging of the skin, triggering repeated oxidative processes.

Too much androgen hormone in men, leads to aging of male skin, making it excessively oily, covered with blackheads. Also, early baldness is associated with this hormone.

The use of gadgets has a negative impact on the quality of the skin. The reason lies in facial expressions: squinting, leading to wrinkles and eye fatigue. According to some theories, smartphones provoke the development of cancer, but this has not yet been proven.

Accelerated aging disease

There is a rare genetic disease, which is called progeria or Werner's syndrome. It is a rare disease, with only 80 cases reported worldwide, but it is worth mentioning.

The disease is associated with a gene defect. In children, this is the LMN gene, and in adults, WRN. Their mutation causes the onset of an irreversible and accelerated process aging. It occurs in children born from parents-relatives. In adults, a factor in the development of the disease is a violation of the metabolism of connective tissue.

Clinical manifestations are characterized rapid aging skin, muscle tissue, bones, the development of early atherosclerosis (30-40 years), diabetes mellitus.
The disease is not curable, there is no cure for it. You can only diagnose it and develop measures to maintain the state, when it is still possible to slow down the onset of old age.

It is possible to slow down aging

Since progeria is extremely rare, and there is no cure for it, it makes no sense to stop your attention on this issue. But regarding premature aging, the picture is different. There are options for correcting this process, slowing down its pace.

Dream. A healthy eight-hour sleep leads to cell renewal, relaxation of the body and mind. During sleep, the nervous system is restored, immunity is strengthened, the skin and all internal organs are regenerated. Night sleep should start at 11 pm. Daily hourly sleep is able to update the state of the body.

Sport. When playing sports, the heart is trained and blood vessels are strengthened. According to statistics, the state of cardio-vascular system at sports active people significantly younger than those who neglect physical activity.

Active training stops early aging of muscle tissue, improves posture and quality of joints.

Active mind. If you think about how the human mind affects aging, then you can slow down the aging process of the body with the help of the mind. The mental attitude directly, literally, starts or slows down all the processes of the body. If you tune in to life and active longevity, then the launch of the longevity program will begin. If you tune in to diseases, then diseases will appear. The human brain is the main commander of everything human body. By making the brain work properly, a person is able to prolong his youth. For this, there are special trainings for auto-training, active consciousness, psychotropic breathing.

Tip: Reading books on transpersonal psychology can go a long way in understanding this issue.

Active mental work. The brain is lazy to the point of disgrace, and if you do not train it, you can grow old ahead of time. An untrained brain makes even a healthy athlete look like a plant with which it is impossible to have interesting conversations. You need to read books, practice memorization techniques. Include all memory methods - kinetic, auditory and visual memory. For more information on brain aging, see a separate article on the subject.

Important: fine motor skills actively trains the brain. Therefore, you can not deny yourself mechanical work.

Active and healthy sex life promotes: good mood, metabolism acceleration, recovery nervous system, body tone, training the heart and muscles.

Important! uncontrolled sex and frequent change partners leads to the exact opposite effect.

Food. Inclusion in your diet of products based on the improvement and help the body in its absorption.

Progeria is rare and incurable disease, with a mechanism not exactly known, formed due to genetic damage. As a result of changes in genes, children are born, progressively and quickly begin to turn into old people. With this disease, the life expectancy of all cells of the body and the whole organism as a whole is sharply reduced. Progeria is dangerous not only in children, but also in adults, the disease can progress from the newborn or from adulthood.
A variant of progeria in infants is called Gilford Hutchinson's syndrome, in adulthood it is billed as Werner's syndrome. In fact, this is premature aging of the body.

The reasons

Progeria is incurable serious pathology, in which premature aging of the child's body occurs, sometimes starting from the prenatal period. This is a genetic breakdown in one of the sections of the genes that are responsible in the body for the aging process of cells and their death. AT normal conditions the aging program starts slowly and in late dates, after maturation of the organism. With progeria, this process is accelerated hundreds of times. Children of both sexes are subject to it, for a short time they turn into old men, although in fact they have absolutely childhood. Occasionally, progreria occurs in adolescents and adults, but this is even rarer.

The formation of progeria at an early age is called Gilford-Hutchinson syndrome, usually boys are somewhat more often affected, on average, the age of children is up to 10-13 years. In rare cases, when special care with progeria, children live up to 18-20 years. The disease cannot be stopped, it progresses and inexorably leads to death.

The mechanism by which the disease develops has not been fully elucidated. big share probability found that the mutation is supplied by a special gene - lamin. This gene and the protein it produces are responsible for the process of proper cell division. If there is a failure in the region of this gene, the cells lose their resistance harmful influences environment and the body starts the aging program. Although this is a genetic disease, it is not inherited, but familial cases can occur - the birth of several children with progeria in a couple.

Symptoms

The manifestations of the disease are quite obvious. Children from a very early age begin to lag behind their peers in terms of physical development. In addition, their body wears out too quickly, becoming what a person usually reaches after 70-90 years. The structure of the skin is disturbed, there are no signs of puberty, and the internal organs are sharply underdeveloped. Children outwardly look like old men, have childish intelligence and are emotionally suffering from a similar disease. Them mental condition is not disturbed in any way, they develop in terms of the psyche according to age.

The body has the proportions of a child, while the areas of cartilage where the bone grows grow rapidly, making the skeleton similar to that of an adult. The child's body suffers from such adult pathologies as diabetes, atherosclerosis, coronary heart disease. Dies usually from senile pathologies.

The main manifestations of progreria:

• At birth, the child practically does not differ from healthy children.
• In the first year of life, height and weight gains lag behind sharply, children have very low height and weight.
• They have a pronounced lack of body fat, and skin tone is sharply reduced, it is wrinkled and dry.
• Hair on the head, eyebrows and eyelashes, all over the body does not grow or falls out quickly.
• The skin has a strong pigmentation like that of the elderly and a bluish tint.
• The skull and bones of the face are disproportionate, the eyes are bulging, the lower jaw is very small, the ears are protruding, the nose is hooked.
• The teeth erupt late and fall out quickly, the voice is high pitched, shrill and hoarse.
• The chest is shaped like a pear, the collarbones and limbs are small, the joints move tightly.

By the age of five, the walls of the vessels are sharply affected by atherosclerosis in children, sclero-like formations form on the skin, especially on the buttocks, thighs and abdomen. suffer large vessels chest and abdomen, the structure and work of the heart changes.

Diagnosis of progeria in children

The basis of diagnosis is typical clinical manifestations. If necessary, medical genetic counseling and the identification of an abnormal gene are carried out. It also shows the examination and identification of complications of pathology.

Complications

The main complications of progeria are the wear and tear of all internal organs, changes in the heart, the formation of strokes and heart attacks, diabetes mellitus and atherosclerosis. Patients die from these diseases after the age of 10 years. The prognosis for pathology is unfavorable, cases of cure are unknown.

Treatment

What can you do

There is no cure for this pathology; you should not spend money on empty promises to cure the baby. So far, there is no way to correct gene defects. shown complete care and maximum social adaptation, good nutrition and baby care. No means traditional medicine from progeria is also not available.

What does a doctor do

Drug treatment is also carried out only for the purpose of maintaining general health and preventing complications. Prophylactic anticoagulants and cholesterol-lowering drugs are shown. Growth hormone can be used to help in the accumulation of weight and growth of children, and physiotherapy is also shown to improve the functioning of the joints and internal organs.

In children with progeria, milk teeth are removed, as permanent ones erupt early.

Prevention

Prevention methods have not been developed, since the pathology is genetic, and it is extremely difficult to influence it. It is worth planning a pregnancy against the background full health, but it is impossible to fully predict the likelihood of having children with progeria.

You will also find out what can be dangerous untimely treatment progeria disease in children, and why it is so important to avoid the consequences. All about how to prevent progeria in children and prevent complications.

And caring parents will find on the pages of the service full information about the symptoms of progeria in children. How do the signs of the disease in children at 1.2 and 3 years old differ from the manifestations of the disease in children at 4, 5, 6 and 7 years old? What is the best way to treat progeria in children?

Take care of the health of your loved ones and be in good shape!

Aging of the human body is the most difficult biological process, which reflects only one side of the development of the organism.

Experts distinguish two types of aging: natural or physiological and premature, which, under the influence of living conditions and various diseases, develops at an accelerated pace.

No matter how sad it is, but the second type, that is, premature aging, is the most common form of decrepitude in our society.

With this type age-related changes occur much earlier than with the physiological, and the biological age prevails over the calendar.

Causes of premature aging

Signs of premature aging often appear by the age of 40, reducing the quality of human life. Among the causes of premature aging, external and internal factors can be distinguished.

Adverse external factors

These include frequent stress, bad habits, failure of the natural biorhythm, malnutrition lead to premature wear of organs and tissues. They are often the cause of diseases that accelerate the biological aging of the body.

People experiencing the above adverse factors are more likely to suffer from arthritis, cataracts, atherosclerosis, dementia, diseases gastrointestinal tract and oncological diseases.

Diseases

There are a number of diseases that rapidly cause signs of premature aging of the body. If a person is sick with cerebral vascular sclerosis, peptic ulcer, tuberculosis, diabetes, immune deficiency, signs of senile decrepitude immediately appear in the body - posture, hair, skin change.

Emotional and mental stress

Harm to health stressful situation are the cause of premature aging. The most dangerous is excessive stress or when it is constant.

The presence of depressing thoughts, the inability to discharge emotionally, to pronounce a disturbing situation or simply switch, fixation on problems - adversely affect the mental and physical health person.

They call:

• muscle tension in the neck and shoulders,
• headache,
• insomnia
• indigestion,
• anxiety
• mood swings,
• negative thoughts
• and feeling tired.

A syndrome chronic fatigue experts consider the model accelerated aging organism.

Constant lack of sleep

Sleep disturbance or insufficient sleep is detrimental to overall health. Each person has his own need for rest, in order to have a good rest and restore your strength, 7-8 hours of sleep is enough.

If a person does not get enough sleep constantly and for a long time, there may be chronic sleep deprivation which leads to violation physiological functions body:

• irritability appears, sense of humor is lost,
• change physiological properties brain, which leads to memory loss and inability to concentrate,
• every day a person experiences headaches and dizziness,
• response is reduced.

And all these signs together create difficulties in solving problems.

Sometimes a person deliberately deprives himself of sleep, explaining this by saying that there is not enough time for creativity or business, mistakenly believing that it is a pity to waste your time on sleep.

Thus, he provokes breakdowns in his health, the restoration of which will spend even more time.

It is also important that it is impossible to sleep off in advance, the body is not adapted to this, and as a result, you can get weakness, lethargy, and a headache.

Similarly, excessive sleep does not bring rest, but fatigue and a decline in strength and energy. Healthy body.

Unbalanced diet

Our cells, tissues and organs need the energy that the body receives from food. Balanced diet contributes to the normal renewal of cells, their rejuvenation.

In a healthy body, liver cells are completely renewed within a year, and young skin cells replace old ones 12 times during this period. In order for cells to rejuvenate, they need a balanced diet.

Often, in human food, the calorie content of food intake exceeds energy costs. Unused energy is stored in the body in the form of fat, and obesity causes a number of health problems and causes aging of the human body.

It must be remembered that the body needs amino acids, vitamins, minerals, trace elements, lecithin, Omega-3, all that is found in natural foods, vegetables, fruits and herbs. Eating right, a person feels full of strength and energy.

Bad habits

Smoking, drinking and drugs are the main bad habits destroying health and life. So smoking causes a powerful blow to the respiratory and cardiovascular system.

Often smoking provokes an increase in pressure, an increase in cholesterol in the blood, which leads to heart disease and stroke.

Excessive alcohol consumption destroys blood cells, which can provoke the occurrence of many diseases, such as pancreatitis, diabetes, gastritis, atherosclerosis and coronary heart disease.

Alcohol destroys the liver, disrupts metabolism, blood sugar regulation functions. No less serious concern is caused by beer alcoholism, which also destroys not only the organs and systems of the body, but also the human psyche.

And drugs lead to complete defeat organism. Drugs are the path to the degradation of society, statistics show that Russia is already in 3rd place in the world in terms of drug use after Afghanistan and Iran.

More than 2.5 million people in our country are addicted to drugs, destroying their health. The heart, blood vessels, brain, digestion, respiration suffer from drugs, the human psyche is disturbed, reproductive ability and immunity are lost. But the most important thing is that drugs significantly shorten a person's life!

Unfavorable internal factors

To internal reasons premature aging of the body can be attributed to the effects of free radicals, autointoxication, autoimmune processes, impaired brain function.

Autointoxication

In the process of normal human life, toxic substances are produced in his body, which are excreted by the body itself. But if excretory system does not cope with its functions, toxic products are again absorbed into the blood, and there is a gradual poisoning of the body with poisons or autointoxication.

This occurs in diseases such as uremia, anuria, constipation and intestinal obstruction, in case of metabolic disorders associated with diabetes mellitus, thyrotoxic goiter, and even with toxicosis of pregnancy. In this case, a person feels unwell, weakness, headache and dizziness, nausea or vomiting.

Autointoxication is eliminated by activating the excretory function of the body, eliminating the causes that caused it, using medications(diuretic and diaphoretic), blood transfusion…. At kidney failure more radical methods are used.

Impact of free radicals

Free radicals are the main cause of premature aging of the body, causing atherosclerosis, cancer, heart attack and stroke, diseases of the skin, immune and nervous system.

The human body has a system for fighting radicals, but antioxidant enzymes do not always cope with them.

The body needs additional protection against free radicals in the form of antioxidants, which act as traps for them. Such traps are plant bioflavonoids, which prevent premature human aging.

It is believed that bioflavonoids and phytohormones contain plants that have a dark pigment color, such as: blueberries, blackberries, blueberries, beets, purple cabbage, dark grapes, prunes, beans, beets, black radish ...

How to avoid premature aging

To avoid premature aging, it is necessary to increase defensive forces body, optimize the activity of organs and systems, compensating for weakened functions and preventing the occurrence of new disorders in the body.

First of all, strive to eliminate the causes leading to premature aging, which were mentioned above.

Review your diet and try to include as much as possible natural products nutrition. Unfortunately, get everything from food necessary components for health and life is very difficult, so you can adjust your diet with the help of dietary supplements.

Medical industry and network companies produce dietary supplements based on marine products, medicinal plants with the addition of bioactive ingredients - peptide molecules of regulatory action that increase the body's bioenergetics.

The balance of sex hormones is essential and the most important factor in maintaining the processes of renewal and rejuvenation in the human body, especially in adulthood. The lack of estrogen, which is involved in the synthesis of collagen, invariably affects the appearance of wrinkles, loss of skin elasticity and its withering, hair loss.

A similar skin aging condition is sometimes seen in young women chasing fad diets. Indeed, in youth, estrogens are produced not only by the ovaries, but also by adipose tissue.

Impossible without water physiological processes. All internal processes in the body proceed with the participation of water, in aquatic environments.

All cells are surrounded by a nutrient gel. containing structurally bound water. And the more water in this gel, the higher the turgor of tissues and cells.

The loss of water by the body is immediately visible on the skin, which loses its turgor and becomes flabby and sagging. The same processes occur with internal organs which often leads to dysfunction.

Therefore, no one doubts that water is the main indicator of body aging. But not all water is equally absorbed by the body. Water with certain physical and chemical parameters is considered useful for the body. They take into account:

• redox potential,
• surface tension,
• mineralization,
• pH and other parameters.

Structured or melted water is most suitable for these parameters.

lifestyle, food, Fresh air, physical work and physical exercises, charging for the brain, its constant training, all these are important components of longevity, therefore, the ability to avoid premature aging depends on each of us.