Trental and its analogues instructions for use. Interaction with other drugs. Which analogue is better

The drug Trental is prescribed for those who have impaired microcirculation. The composition of the drug includes pentofxifillin, which is its active and active ingredient. It quickly improves the rheological property of the blood.

With its help, blood viscosity is significantly reduced, due to the normalization of the elasticity of red blood cells. This is the main and important action this medicine, there are many more medicinal properties that it has on the human body, they are all useful and important for the normal functionality of a person.

Indications for the use of Trental:

• death of tissue cells, various trophic ulcers;
• frostbite of varying degrees;
• asthma, bronchitis and other pathologies of the respiratory system, with difficulty in the passage of air;
• Raynaud's disease;
• circulatory failure in the middle ear, retina;
• violation cerebral circulation, ischemic stroke;
• vascular impotence in men.

Analogues of Russian production

The table will characterize some analogues of Trenatal of a domestic manufacturer.

Ukrainian substitutes

1. Pentoxifylline solution for injection. 2%, in ampoules. The price is 40-55 rubles. Ukrainian production, Darnitsa plant. Recommended for use to improve microcirculation, blood oxygenation. It leads to the usual and normal condition erythrocytes and platelets.

   Doctors strongly recommend for lung diseases that make breathing difficult. This drug dilates the vessels of the lungs, provides complete oxygenation. It also has a good effect on the myocardium, providing it with oxygen and all the necessary nutrients.

2. Latren. Produced in the form of a solution. Bottles of 100, 200 and 400 ml. The price is 120-240 rubles. Inexpensive drug, which is prescribed for circulatory disorders in the eyeball, ear dysfunction, with partial hearing loss.

   Also with atherosclerotic encephalopathy, ischemic stroke, diabetes mellitus with apathy, trophic inflammations, which are associated with a violation of the integrity of the integument.

3. Pentoxifylline. In tablets of 100 ml, No. 10, No. 50. The price is from 40 to 60 rubles. Well helps people suffering from Raynaud's disease, diabetes of any type. It is used for gangrene, frostbite, ulcers, with a large area of ​​affected tissue and dead cells.
4. Pentoxifylline-Health. The drug is in the form of a solution for injection. It is recommended for disorders of the peripheral circulation in the extremities, which is associated with atherosclerotic plaques and diabetes.

   This medicine well and quickly normalizes blood cells, provides oxygen to all organs and tissues.

5. Pentoxifylline Sopharma. Tablets. One such tablet contains 100 mg of pentoxifylline.

   The drug has a good effect on the blood circulation of the whole body, improves rheological properties blood, reduces its viscosity and prevents the participation of red blood cells in destructive processes.

6. Pentotren. Produced in the form of a solution. Its color can be from transparent to yellowish, but also transparent.

   It increases the flexibility of blood cells, inhibits their aggressive effect on tissue destruction, dilates blood vessels, reduces peripheral resistance, and has a healing effect.

Belarusian generics

Modern medicines on the market are very competitive. Most cheap drug may be more effective and at the same time have fewer side effects.

Belarus has always been distinguished by the high quality of any product that is produced in their country. Belarusian generics are not very common, but are in demand.

Other foreign analogues

Imported close substitutes are better and more reliable.

1. Agapurin. Tablets 190, 280, 320 rubles, depending on the dosage, solution 125 rubles. Designed to improve blood circulation in the limbs, to prevent blood clots and in bronchial asthma. It is prescribed even during pregnancy.
2. Pentoxifylline. Tablets 70-100 rubles, solution 30-40. Indicated for atherosclerosis coronary disease heart, improves peripheral circulation. Assign for ulcers on the lower extremities, diabetes.
3. Flexital. Tablets 250-270 rubles. Used for thrombosis, frostbite, varicose veins veins. With impaired peripheral and cerebral circulation.
4. Pentilin. Tablets 120-180 rubles, depending on the dosage. Solution 80-95 rubles. It is indicated for violations of blood circulation in the heart, ischemic attack, diabetes, otosclerosis.
5. Latren. Available only as a solution, 200 ml. The price is 120-130 rubles. It helps very well with dermatitis, Raynaud's disease, violation of the trophic function of any tissues of the body.

   also in complex treatment used to treat diabetes, ischemic stroke, restore blood circulation eyeball, normalization of circulation in the brain.

As you can see, there is something to replace Trenatal. Such a selection list allows you to choose for yourself, individually, the best drug, replaced by cheap analogue if financial situation does not allow.

Trental, and analogues are cheaper than the drug itself, it is worth using carefully, following the doctor's recommendations, and following the instructions. Possible in case of overdose adverse reactions that worsen general state organism.

Prices are different, but characterized by a slight difference.

Not always, cheap drug taxes justify themselves.

When the first symptoms appear, you should immediately go to the hospital. Without medical treatment and blocking the effects of pentofxifylline on the body, very large and detrimental consequences can occur.

Finally, I want to remind you what to replace this drug many medicines are possible. All the names listed in the article are synonymous and have the same effect on the human body. Before replacing, it is always worth consulting with your doctor, taking into account all the recommendations and carefully approaching your health.

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pharmachologic effect

Vasodilating drug that improves microcirculation. Trental ® 400 improves the rheological properties of blood by affecting the pathologically altered deformability of erythrocytes, inhibiting platelet aggregation and reducing increased viscosity blood. Trental ® 400 improves microcirculation in areas of impaired circulation.

The active substance of the drug - pentoxifylline - is a derivative of xanthine. The mechanism of action of pentoxifylline is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in cells. smooth muscle vessels and in shaped elements blood.

It has a weak myotropic vasodilating effect, slightly reduces OPSS and slightly expands coronary vessels.

The use of Trental 400 leads to an improvement in symptoms in violations cerebral circulation.

With occlusive lesions of peripheral arteries (for example, with intermittent claudication), the effect of the drug is manifested in lengthening the walking distance, eliminating night cramps in calf muscles and the disappearance of pain at rest.

Pharmacokinetics

Suction

After oral administration, pentoxifylline is almost completely absorbed from the gastrointestinal tract.

Bioavailability averages 19±13%.

Metabolism

The main pharmacologically active metabolite 1-(5-hydroxyhexyl)-3,7-dimethylxanthine is determined in plasma at a concentration that is 2 times the concentration of the unchanged substance (pentoxifylline).

Pentoxifylline is completely biotransformed in the body.

breeding

T 1/2 pentoxifylline is 1.6 hours.

More than 90% is excreted by the kidneys in the form of unconjugated water-soluble metabolites.

Pharmacokinetics in special clinical situations

In patients with severely impaired renal function, the excretion of metabolites is slowed down.

In patients with impaired liver function, an elongation of T 1/2 of pentoxifylline and an increase in its bioavailability were noted.

Indications

- disorders of the peripheral circulation of atherosclerotic origin (for example, intermittent claudication), diabetic angiopathy, trophic disorders (eg, leg ulcers, gangrene);

- disorders of cerebral circulation (consequences cerebral atherosclerosis, such as impaired concentration, dizziness, memory impairment), ischemic and post-stroke conditions;

- circulatory disorders in the retina and choroid eyes;

- otosclerosis, degenerative changes against the background of vascular pathology inner ear and hearing loss.

Dosing regimen

Set individually.

The average dose of the drug for oral administration is 400 mg (1 tab.) 2-3 times / day. Maximum daily dose- 1200 mg (3 tab.).

Tablets are taken whole, without chewing, during or immediately after a meal, washed down enough water.

At patients with liver failure the dose of the drug is reduced taking into account individual tolerance.

In patients with arterial hypotension, as well as in persons at risk due to possible reduction AD (patients with severe coronary artery disease or with hemodynamically significant cerebrovascular stenoses), treatment can be started in small doses. In these cases, the dose increase should be carried out gradually.

Side effect

From the side of the central nervous system: headache, dizziness, anxiety, sleep disturbances, convulsions; very rarely - aseptic meningitis.

Dermatological reactions: hyperemia of the skin of the face, flushes of blood to the skin of the face and upper part chest, swelling, increased fragility of nails.

From the side digestive system: xerostomia, anorexia, intestinal atony, feeling of pressure and fullness in the stomach, nausea, vomiting, diarrhea; very rarely - intrahepatic cholestasis, increased activity of hepatic transaminases, alkaline phosphatase.

From the side cordially- vascular system: tachycardia, arrhythmia, cardialgia, progression of angina pectoris, decrease in blood pressure.

From the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia.

From the blood coagulation system: bleeding from the vessels of the skin, mucous membranes, stomach, intestines, hypofibrinogenemia.

From the sense organs: visual impairment, scotoma.

Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock.

Side effects develop when using Trental 400 in high doses.

Contraindications for use

— acute infarction myocardium;

- massive bleeding;

- hemorrhage in the brain;

- massive retinal hemorrhage;

- pregnancy;

- lactation ( breast-feeding);

- children's and adolescence up to 18 years;

— hypersensitivity to the components of the drug.

- Hypersensitivity to other derivatives of methylxanthine.

FROM caution the drug should be used in patients with severe arrhythmias (risk of worsening arrhythmias); arterial hypotension (risk of further decrease in blood pressure); chronic heart failure; peptic ulcer and duodenum; impaired renal function (CC less than 30 ml / min) (risk of cumulation and increased risk the development of side effects); severe hepatic impairment (risk of cumulation and increased risk of side effects); after a recent surgical interventions; with a tendency to bleeding, for example, as a result of the use of anticoagulants or in violation of the blood coagulation system (risk of more severe bleeding).

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy.

If necessary, the use of the drug during lactation should stop breastfeeding.

Use in children

Overdose

Symptoms: urge to vomit, dizziness, tachycardia, decreased blood pressure, arrhythmia, hyperemia skin, chills, loss of consciousness, areflexia, tonic-clonic convulsions.

Treatment: stop the drug, give the patient horizontal position with raised legs. Holding symptomatic therapy maintaining blood pressure and respiratory function. It is necessary to monitor the free passage respiratory tract. At seizures administer diazepam.

drug interaction

Pentoxifylline enhances the effect of drugs that reduce blood pressure ( ACE inhibitors, nitrates).

Pentoxifylline can enhance the effect of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins).

Cimetidine increases the plasma concentration of pentoxifylline (risk of side effects).

Co-administration with other xanthines can lead to excessive nervous excitement.

The hypoglycemic effect of insulin or hypoglycemic drugs may be enhanced when taking pentoxifylline (increased risk of hypoglycemia). Such patients require strict clinical monitoring.

With the simultaneous use of pentoxifylline and theophylline, it is possible to increase the concentration of theophylline in the blood plasma and increase the side effects of theophylline.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

List B. The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25°C. Shelf life - 4 years.

Application for violations of liver function

Careful monitoring is required in patients with severe violations liver function (risk of cumulation and increased risk of side effects).

Application for violations of kidney function

At patients with severe renal dysfunction (CC less than 30 ml / min) the dose may be reduced to 400-800 mg/day.

Careful monitoring is necessary in patients with severe renal impairment with CC less than 30 ml / min (risk of cumulation and increased risk of side effects).

Use in elderly patients

special instructions

Treatment should be carried out under the control of blood pressure.

In diabetic patients taking hypoglycemic agents, the administration of the drug in high doses can cause severe hypoglycemia (dose adjustment is required).

When administered simultaneously with anticoagulants, it is necessary to carefully monitor the parameters of the blood coagulation system.

In patients who have recently undergone surgery, systematic monitoring of hemoglobin and hematocrit levels is necessary.

In patients with low and unstable blood pressure, the dose should be reduced.

In elderly patients, it may be necessary to reduce the dose of the drug (increase in bioavailability and decrease in the rate of excretion of pentoxifylline).

Smoking may reduce the therapeutic efficacy of the drug.

Pediatric use

The safety and efficacy of pentoxifylline in children have not been well studied.

Drugs that improve microcirculation in the brain tissues and have an anti-ischemic effect are widely used in neurology. is one of the most popular capillary stabilizers, it contains pentoxifylline, a derivative of methylxanthine. If necessary, Trental can be replaced with a cheaper analogue that has the same therapeutic effect.

Main indications for use:

• intermittent claudication caused by blockage of peripheral arteries lower extremities(stage 2b according to Fontaine);
• chronic and acute hypoxia of the brain;
• microangiopathy in diabetes mellitus;
• circulatory insufficiency of the retina;
• atherosclerosis;
• cardiac ischemia;
• angioneuropathy (Raynaud's disease);
• hearing impairments that are complications vascular pathology;
• encephalopathy.

Trental should not be prescribed with an increased tendency to bleeding and coagulopathy, hemorrhagic stroke, in acute period transmural infarction myocardium, inflammatory diseases gastrointestinal tract(gastritis, duodenitis, colitis, peptic ulcer).

The drug is produced by Sanofi Aventis in India and France in the form of prolonged-release tablets for internal use and solution for injection. Dispensed with a prescription from a doctor.

Trental is available in several dosage forms:

1. Tablets 0.4 g No. 10 and 20, 0.1 g No. 60;
2. Injection solution in ampoules of 5 ml at a concentration of 1 and 2%, 5 ampoules in 1 package.

The cost of this drug is much higher than the price domestic analogues and depends on the policy of the pharmacy network.

Analogues of the drug Trental in tablets

Most convenient in outpatient settings use Trental tablets. For getting maximum effect it takes a long time and regular treatment. Since not all patients can buy expensive imported drug, there is a need to select cheaper and more efficient analogues.

Agapurin

Treat microcirculation correctors and developed on the basis of pentoxifylline. long time used in neurology to normalize the blood supply to brain tissues and eliminate ischemia. The effectiveness of this drug has been confirmed large quantity clinical research.

The drug has not only a vasodilating effect, but also improves the rheological properties of the blood. Due to the inhibition of phosphodiesterase activity in platelets, their ability to adhere is reduced. In erythrocytes, under the action of pentoxifylline, the energy potential increases and oxygen saturation improves. The drug has a positive effect on the tone of the muscles of the respiratory system.

Feature is the presence of tablets with prolonged release active component- pentoxifylline. This allows you to maintain a constant concentration in the blood and achieve the most smooth and soft effect. It is prescribed for cerebrovascular diseases, peripheral circulatory disorders, hearing and vision impairment of vascular origin. Contraindications - blood clotting disorders, acute period of myocardial infarction and hemorrhagic stroke.

The drug is produced by the pharmaceutical companies Slovakopharm and Zentiva in the Slovak Republic. Release forms and doses:

• injection solution 2%, 5 ml;
• dragee No. 60, 0.1 g in dark glass bottles;
• tablets of 0.4 and 0.6 g in blisters of 10 pcs.

At the moment, the drug is temporarily out of stock due to expiration and re-registration.

Vasonite

At the moment, only packs of 20 sustained-release tablets with a dosage of 600 mg are available for sale. Producer - Pharma GmbH, Austria.

According to International classification according to anatomical and therapeutic properties, these tablets are assigned the code C04 AD03, which corresponds to the group of peripheral vasodilators. The generic name that is used in the literature is Pentoxyphyllinum. By chemical structure the drug is a derivative of purine.

Main clinical effects:

• antithrombotic. Associated with a decrease in the ability of platelets to stick together;
• anti-ischemic - expands the coronary vessels, improves the supply of oxygen to the heart muscle;
• vasoconstrictor - protects the capillary walls from damage.

Widely prescribed for the prevention and treatment of myocardial infarction, vascular encephalopathy, microcirculation disorders and trophic damage to soft tissues, diabetic neuro- and angiopathy, atherosclerosis.

Tablets are not used in the presence of a history of hemorrhages in the retina, hemorrhagic stroke, increased risk bleeding.

When prescribing to patients prone to the development of hypotension, having heart failure, severe liver and kidney failure, exacerbation of gastritis, duodenitis or peptic ulcer, treatment is carried out according to strict indications under medical supervision.

The treatment regimen depends on the severity pathological symptoms. The average daily dose is 1.2 g. In most cases, Vasonit is recommended to take one tablet once or twice a day after meals. The tablet should not be sucked, broken or crushed, since if the shell is damaged, the pharmacokinetic properties of the drug may be violated.

Flexital

The drug of the Indian pharmaceutical company "Sun Pharmaceutical Industries" based on pentoxifylline, which belongs to the group of adenosinergic drugs. It has antiaggregatory, vasodilating, antihypoxic effects. The mechanism of action is associated with the blocking of adenosine receptors and inhibition of the activity of the phosphodiesterase enzyme. The drug reduces blood viscosity, improves oxygen delivery to tissues nervous system. AT clinical practice used to improve peripheral arterial and arteriovenous circulation.

Contraindications to the appointment are increased bleeding, intolerance to one or more components, an acute period of stroke and heart attack. If it is necessary to carry out surgical interventions, Flexital treatment is temporarily stopped.

While taking the drug, adverse reactions such as allergies, skin rash, irritability, decreased blood pressure, anxiety, heart pain, increased heart rate. It is forbidden to use Flexital for pregnant, lactating women and persons under 18 years of age, since the safety of use in these categories of citizens has not been proven.

The duration of the course of treatment is at least 6-7 weeks. According to the instructions, the recommended daily dose is 800-1200 mg, which corresponds to 2-3 tablets. It must be divided into several doses throughout the day. Tablets to be taken clean water, do not chew.

Flexital is available in the form of enteric tablets with a single dosage (400 mg). Packages No. 20 and No. 50 are available for sale. Holiday conditions - with a prescription.

Analogues of the drug Trental in the form of a solution for injections

Pentoxifylline is active component many injection solutions, which are intended for intravenous and intramuscular effect. This form of the drug is in most cases used in a hospital during the acute period of the disease to obtain the fastest possible effect.

Latren

Infusion solution containing pentoxifylline at a concentration of 0.05%. Available in transparent glass bottles of 100, 200 and 400 ml. Produced in Ukraine TOV "Yuriya-Pharm".

The drug is indicated in the following situations:

• encephalopathy of vascular etiology;
• violations of microcirculation in the tissues of the limbs, which are accompanied by paresthesia, trophic ulcers, gangrene;
• diseases venous vessels: phlebitis, thrombosis and their residual effects;
• ischemic stroke;
• neurological symptoms after cerebral hemorrhage;
• traumatic brain injury.

Latren is not used to treat patients who have disorders heart rate, with a labile level of blood pressure, hypotension, acute bleeding, thrombocytopathies.

Against the background of treatment, adverse reactions may develop, which stop when the drug is discontinued. Among them are redness and itching of the skin, rash, Quincke's edema, nausea, dizziness and headache, convulsions, numbness of the extremities, tinnitus.

Latren is prohibited for use in pediatric practice, during pregnancy and lactation.

The frequency and volume of infusion is determined by the attending physician, taking into account the results of the tests and the severity of the disease. Most often, 400-600 ml of Latren is administered intravenously, drip for 1-2 hours 2 times a day. Continuous administration for 24 hours is allowed. The maximum daily dose is 1200 mg (no more than 1.4 liters of solution).

Pentotren

The drug is produced by the Ukrainian pharmaceutical company Darnitsa. Due to its low cost and proven effectiveness, it has become one of the most popular solutions that are used for treatment. neurological diseases caused by insufficient blood supply tissues of the nervous system.

Pentotren has a vasodilating and capillary-stabilizing effect, helps to quickly eliminate the manifestations of hypoxia of the cerebral cortex, improves microcirculation in peripheral tissues.

Sold in bottles of polymer materials 200 ml, concentration 0.05% (5 mg / ml). The most preferred route of administration is intravenous. During the infusion, you can dilute Pentotren isotonic saline sodium chloride, Ringer's solution or glucose 4%. A combination with tablet forms of pentoxifylline is allowed, subject to the recommended doses.

Contraindications:

• childhood;
• pregnancy and lactation;
• hereditary blood diseases;
• peptic ulcer of the stomach and intestines.

In case of individual intolerance, as well as exceeding the dosages recommended in the instructions, side effects may occur: headache, flies in the eyes, nausea, weakness, changes in heart rate and blood pressure, impaired intestinal motility.

Trenpental

The drug belongs to the group of angioprotectors and microcirculation correctors. Active active substance Pentoxifylline is a phosphodiesterase and cAMP inhibitor.

Trenpental is available in Russian Federation pharmaceutical company CJSC Bryntsalov-A. According to official instructions provided by the manufacturer, the drug is used to treat and prevent complications of atherosclerosis, diabetes, with angiopathy, visual impairment and hearing loss of vascular origin.

The release form is a concentrated 2% solution of pentoxifylline in 5 ml ampoules. Before infusion, it must be diluted in isotonic saline solution in the required proportion. The volume of the solvent depends on the method of administration:

• intra-arterial - 5 ml of Trenpental in 20-50 ml of sodium chloride;
• intravenous drip - 1 ampoule per 200-400 ml of NaCl 0.9%.

During the injection, a feeling of heat, clouding of consciousness, redness of the skin, increased sweating. When the desired result is achieved, it is possible to switch to tablets.

It is forbidden to prescribe this drug to children, pregnant and lactating women, as there are no reliable data confirming its effectiveness and safety.

Substitutes available in several dosage forms

Since in the treatment of acute vascular pathology is often used step therapy, which is to use injection forms with the transition to oral when clinically effective, most manufacturers produce drugs in different forms.

Pentoxifylline

It is one of the cheapest drugs from the group of nootropics. Peripheral vasodilator. Due to the improvement of microcirculation, it improves the delivery of oxygen to the tissues and eliminates the manifestations of hypoxia.

The following domestic forms of Pentoxifylline are available for sale:

• tablets of 0.1 and 0.4 g. They can be packed in foil blisters of 10 pieces, plastic and glass bottles No. 50. Talc, microcellulose, macrogol are used as auxiliary substances in their production. Unlike imported analogues they do not have a shell that protects against premature dissolution in the aggressive environment of the stomach, therefore they have a less pronounced effect;
• 2% solution in 5 ml ampoules. Requires additional dilution in a solution of sodium chloride or glucose.

Pentilin

A feature of Pentilin is the variety of forms of release. In addition to enteric tablets of 400 mg and 2% concentrate for injection of 5 ml, there is a 3% solution in 15 ml ampoules.

Indications and contraindications for use are the same as similar means that contain pentoxifylline. The treatment regimen is selected individually, taking into account the intensity of pathological symptoms and concomitant diseases. At oral administration the maximum daily dose (1.2 g) is divided into 2-3 doses. Injections should be carried out 1-2 times a day. Continuous round-the-clock infusions are allowed.

Pentilin goes well with other medicines. Against the background of taking antihypertensive drugs, hypotension may develop. Pentilin should be used with caution in patients receiving antiplatelet agents ( acetylsalicylic acid, clopidogrel), anticoagulants (warfarin), theophylline, vitamin K, insulin and hypoglycemic drugs(metformin).

The drug does not affect cognitive function, concentration and reaction speed. There is no experience of use in pregnant and lactating patients.

Substitutes for Trental by mode of action

In case of intolerance to pentoxifylline and other methylxanthine derivatives, as well as in the presence of contraindications to their use, it becomes necessary to select a remedy with similar therapeutic properties. Replacement of the drug is carried out by the attending physician on an individual basis.

halidor

The drug is produced in Hungary at the Egis pharmaceutical plant. international generic name- Bencyclanum. Under trade name available in the following dosage forms:

• tablets 0.1 No. 50;
• Solution 2.5%, 2 ml ampoules No. 10.

The active ingredient is benziklan. By pharmacological properties belongs to the group of antispasmodics, and according to the ATC classification, it is assigned the code C04 AX 11 Peripheral vasodilators.

Under the action of bencilan, the vessels of the microcirculatory bed expand, and tissue nutrition improves. Halidor also has a moderate sedation. positive quality is the lack of influence on the level of blood pressure, which allows its use against the background of antihypertensive therapy.

The main indications for the appointment:

• vascular diseases (atherosclerosis, endarteritis, Raynaud's disease);
• acute disorders of cerebral blood flow;
• postoperative and post-traumatic neurological and vascular disorders;
• angiopathy of various etiologies;
• vascular eye diseases, including retinal artery occlusion;
• spastic and hypermotor dyskinesia biliary tract, intestines;
• renal and biliary colic.

The drug should not be used for respiratory and liver failure, arrhythmias, during pregnancy and lactation.

Xanthinol nicotinate

International pharmaceutical reference books use the generic name Xantinoli nicotinas. As a result of the last re-registration, the drug was assigned the code C04AD 03 Vasodilators.

The Ukrainian pharmaceutical corporation Arterium produces in the following forms:

• tablets 150 mg, 10, 20 and 60 pieces per pack;
• 1.5% solution for injection in ampoules of 2 ml. Each package contains 10 ampoules.

Xanthinol nicotinate is a derivative of purine, combines the properties nicotinic acid and theophylline. The mechanism of action is realized due to the blocking of phosphodiesterase and adenosine receptors, an increase in the concentration of high-energy compounds (cAMP), stimulation of the synthesis of prostacyclins and nicotinamide coenzymes. Under the action of the drug, vascular resistance decreases, the ability of platelets to adhere decreases, nutrition and metabolism of peripheral organs and tissues improves. Xanthinol has hypolipidemic properties, lowers cholesterol, enhances fibrinolysis.

Indications:

• intermittent lameness;
• atherosclerosis;
• arterial and venous thrombosis;
• trophic ulcers;
• retinal disinsertion.

The drug is contraindicated in glaucoma, HF 2-3 degree, stenosis mitral valve, acute and chronic kidney failure, hemorrhagic diseases.

To eliminate the manifestations of vascular pathology, the drug is administered by intravenous and intramuscular injections. In case of visual impairment and pathology of the retina, physiotherapy (iontophoresis) is prescribed.

Nicergoline

By pharmacological properties, it belongs to the group of correctors of cerebral circulation. The active ingredient is nicergoline, a derivative of ergoline. This substance blocks alpha-adrenergic receptors, which causes vasodilation. Normalizes hemodynamics in the brain positive influence on the metabolic processes in nervous tissue, reduces blood viscosity and aggregation properties of formed elements.

Used to correct cerebral hemodynamics, eliminate hypoxia in diseases such as arterial hypertension, atherosclerosis, vascular dementia. Can be used in combination therapy complicated hypertensive crises.

Available in the form of a lyophilisate for i / m administration. Each ampoule contains 4 mg of nicergoline, tartaric acid and milk sugar are used as auxiliary components.

Before administration, the contents of one ampoule must be diluted in 5 ml of saline. The treatment regimen is selected individually.

Trental is used to improve blood microcirculation, tones the respiratory muscles, dilates blood vessels and increases their elasticity. If unable to use original drug specialists prescribe analogues of Trental, which best meet structural elements constituent components.

What is Trental

The active element of the drug Trental is pentoxifylline, which is used to reduce the viscosity and density of the blood, prevents sclerotation and thrombosis, controls motor activity erythrocytes.

Used Trental for venous insufficiency, circulatory disorders, trophic ulcers, vascular impotence in men various pathologies respiratory organs.

The preparation contains 100 mg of the active substance in one tablet, and the excipients are talc, silicon dioxide, starch, lactose. The 400 mg tablets contain povidone and hyetellosis. Another form of release of Trental is a powder for injection, 5 ml.

Brief instructions: take the drug with food or after drinking a small amount liquid, exact dosage determined by the treating doctor. The daily dose is not more than 1200 mg.

Achieving a therapeutic effect is observed within an hour of taking the tablet form. The remains of the drug are excreted by the kidneys, the period is from 30 minutes to 1 hour. Injections are carried out intravenously 2 times a day.

The current price for 100 mg is 455 and 2347 rubles. (400 mg), concentrate - 160 rubles.

Trental's analogs

Among structural analogues drug Trental, the following pharmaceutical products can be distinguished:

• Agapurine - to improve blood flow to the limbs, prevent thrombosis. Available in tablets of 100, 400, 600 mg. Contraindications are identical with Trental, you can add darkening to the eyes, severe headaches in the back of the head, trembling of the limbs. In comparison with the original, it is excreted from the body longer by 30 minutes. At the price of 100 mg up to 200 rubles;
• Pentilin - solves problems with peripheral arterial circulation, prescribed for otosclerosis, erectile dysfunction. Available in tablets of 100 and 400 mg, as well as a concentrate for solution. In case of an overdose, the analog drug causes palpitations, dizziness, nausea, and asthma attacks. At the price of 100 mg tablets - 150 rubles;
• Flexital - is used in violation of tissue trophism, severe thrombosis, varicose veins in severe stages disease progression. Release form - tablets 400 mg. Displayed an hour longer than Trental. average price for the drug - about 250 rubles;
• Latren - used in combination with venotonics in the treatment of varicose veins, the action is aimed at improving blood circulation in the vessels and thinning the blood. An analogue is produced in the form of a solution for injection, the remains of the drug are excreted by the kidneys 1.5 hours after ingestion. Cost - 130 rubles.

Attention!

The preparations differ in the forms of release, the amount of the active substance - pentoxifylline, the price range, the individual intolerance of the components, but they have a similar bioavailability for the body, at least 85%.

Detailed comparison of Trental and Pentoxifylline

The most popular, effective and inexpensive analogue Trental tablets is Pentoxifylline. The medicinal product belongs to the group of angioprotectors, is prescribed to reduce blood viscosity, expand blood vessels and increasing their strength, filling muscle tissues with oxygen, eliminating cramps in the calf area.

Both the original drug and its analogue are equally effective in the treatment of vascular pathologies, both have a single list of contraindications:

• low blood pressure;
• The period of pregnancy and lactation;
• Bleeding;
• Hemorrhage in the retina.

Medicines are not taken by patients after myocardial infarction, only at the stage rehabilitation therapy under the supervision of the attending physician.

The differences lie in the price - the low cost of Pentoxifylline is no more than 100 rubles, and the bioavailability is reduced by 5%, the elimination time from the body in Trental is 30 minutes less than its counterpart.

On a note!

When buying a substitute for Trental, you should give preference to a medicine of its relative quality and manufacturer, and not a price equivalent, because healing effect may be an order of magnitude lower.

Trental and Vasonite

Medicines are used to reduce blood clotting, improve microcirculation, better supply of oxygen to tissues, dilate blood vessels, which will avoid the development of thrombophlebitis.

Vasonite has a high bioavailability, over 94%, a long half-life of about 3 hours. Produced in the form of tablets of 600 mg of the active element, it accumulates in the deep layers of the epidermis.

The current price of the analogue is up to 300 rubles, which is 2 times lower than the original. Side effects and contraindications are identical, the dosage is selected in individual case according to the patient's indications.

Trental's analogs in ampoules

If necessary, the introduction into the body medicinal solution you should choose the following medications:

• Pentilin;
• Latren;
• Agapurin;
• Pentoxifylline.

Pharmaceutical products are used in ampoules for severe forms cerebrovascular accident, stroke. AT rehabilitation period after a heart attack.

List of cheap substitutes

You can find analogues of Trental cheaper than the generics described above. These are domestic and foreign drugs:

• Pentoxifylline-Eskom, from 250 rubles;
• Pentotren, from 120 rubles;
• Flexital - up to 270 rubles;
• Pentoxifylline - Health, from 220 rubles;
• Pentoxifylline Sopharma, up to 300 rubles;
• Vazonite Retard - 300 rubles;
• Nicergoline - no more than 160 rubles;
• Halidor - 246 rubles.

It is important to use Trental and its analogues in the treatment of varicose veins and other disorders of the vascular system under the supervision of a specialist. In addition to the same active substance, each preparation contains various dietary supplements and chemical elements which may be contraindicated for a particular patient.

Which analogue is better?

The advantage of all generics of Trental is low cost. Ideal in terms of price, quality and shape is Pentilin, but with aggressive treatment Pentoxifylline is more suitable, due to the small dosage of the active substance.

On a note!

Bioavailability structural substitute is also inferior to the original, but Pentoxifylline has much more side effects - hallucinations, tremors of the limbs, dry mouth, change in taste, runny nose, wet cough.

Alternatively, you can use Vasonite in an amount of 600 mg, but a wide range effects among all substitutes are different ampoules of Latren, with hyperemia of the skin, hot flashes, increased fragility of blood vessels and capillaries.

With self-selection medicinal product can cause irreparable harm to the body. Save on treatment or not - it's up to you, but remember that your life, health and well-being are at stake.

They have the same properties and mechanism of action. But they also have significant differences. To choose the right substitute, you need to evaluate all its qualities and shortcomings.

Briefly about Trental

This is a drug from the Indian company Sanofi. It reduces blood viscosity and prevents thrombosis. The medicine is produced in the form of tablets of 100 or 400 mg and a concentrate for solution.

The active substance is pentoxifylline. It normalizes microcirculation and eliminates the symptoms of venous insufficiency (convulsions, numbness,). Tablets and solution are used for, and angiopathy.

The dosage is 100 mg three times a day with meals. With a subsequent increase in dose up to 200 per dose. The highest daily dose is 1200 mg.

The medicine is contraindicated in:

• tendency to bleed;
• strokes;
• lactase deficiency;
• heart attacks;
• allergies to pentoxifylline and auxiliary components.

Trental is not prescribed during pregnancy, lactation and until the age of 18. The drug may cause side effects from the following body systems:

• nervous;
• cardio - vascular;
• immune;
• hematopoietic;
• digestive.

On a note!

The cost of medicine in ampoules is from 160 rubles for 5 pieces of 5 ml. The price of the drug in tablets of 0.1 g varies from 500 rubles. for 60 pieces. The same amount, but 400 mg each costs about 1500 rubles. The higher the dosage, the longer the effect of the active substance.

The best analogues

Trental's analogues are no less effective on. Thanks to a single active substance drugs work well with local and common symptoms vascular insufficiency. Most analogues can be added to the list of the cheapest substitutes:

1. Flexital;
2. Pentoxifylline;
3. Agapurin;
4. Vasonite;
5. Trenpental;
6. Pentilin.

These are the most popular pentoxifylline-based products. They are prescribed for varicose veins and currents. Therapy is carried out by taking tablets orally, intramuscularly and intravenous injections. There are no external funds under such names.

Drugs that reduce blood viscosity and dilate blood vessels should be used under control clinical analysis blood and blood pressure.

Pentoxifylline

Under this name, analogues of the drug are produced mainly Russian production. But it is also produced in Belarus, India, China, Germany and Slovakia.

Unlike Trental, the medicine has finished form solution for injection. The drug eliminates pain, heaviness in the legs and cramps. Pentoxifylline is prohibited during pregnancy and lactation. Treatment in pediatrics has not been studied. Dosing is individual depending on the stage of pathology. The treatment regimen is determined. Among the side effects:

• dizziness;
• nausea;
• vomit;
• sleep disturbance;
• anxiety;
• hypotension.

On a note!

The cost of an analogue is from 90 rubles for 60 pieces of 0.1 g each. The solution costs from 50 rubles 10 ampoules. This is the cheapest drug of all substitutes.

Flexital

This is an Indian drug from Sun Pharmaceutical Industries Ltd. It is used in chronic vascular insufficiency with circulatory disorders. The tool is shown with:

• violations of the trophism of the skin;
• venous ulcers;
• vascular thrombosis.

The drug has a high bioavailability (above 90%). Available in dosages of 400 and 100 mg, as well as in the form of a concentrate for infusion. Related to drugs long-acting. It has serious side effects and interacts with antibiotics, anticoagulants, and blood pressure medications.

Trental and its analogues are prescribed only by a specialist and according to strict indications for treatment. You should not independently purchase it from dubious companies.