Arcoxia - instructions, use, indications, analogues, side effects. Arcoxia medicine: special instructions for use. What is Arcoxia

Etoricoxib is a selective inhibitor of inducible cyclooxygenase (COX-2). In a therapeutic dosage, it prevents the production of prostaglandins and arachidonic acid. Inhibition of enzymes involved in the biosynthesis of inflammatory mediators is accompanied by a decrease in the severity of inflammatory reactions in tissues.

According to clinical tests, Arcoxia does not affect the function of the gastrointestinal mucosa and blood plates (platelets). At the same time, etoricoxib does not affect the biosynthesis of constructive cyclooxygenase, which stimulates the transformation of arachidonic acid into prostacyclins. In the course of studies, the effect of NSAIDs on the rate of platelet aggregation provoked by collagen was not established.

The therapeutically active components of the anesthetic drug are rapidly absorbed into the bloodstream through the walls of the gastrointestinal tract. The bioavailability of etoricoxib when taken orally is 99-100%. The maximum rate of reaching the peak concentration of metabolites in plasma is 60 minutes when taking at least 120 mg.

Eating practically does not affect the intensity of absorption of NSAID components. The parallel use of antacids does not affect the pharmacokinetic properties of the drug.

Upon penetration into the blood, etoricoxib binds to albumin by at least 92-95%. In the case of taking 120 mg of the drug, the volume of redistribution of active substances in the equilibrium state is 125 liters. It is known that the active metabolites of NSAIDs penetrate the hematoplacental and blood-brain barrier.

Under the influence of cytochrome P450 isoenzymes, etoricoxib is metabolized in the parenchyma to 6-hydroxymethyl-etoricoxib. No more than 1% of the active substances are excreted unchanged by the kidneys. Etoricoxib is cleaved to 5 different metabolites, most of which do not affect COX-1 and have low activity against inducible cyclooxygenase.

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Description of the drug

Arcoxia is a non-steroidal anti-inflammatory drug with antipyretic, analgesic properties. The drug belongs to the group of selective cyclooxygenesis agents. It is used to treat diseases of the articular tissue. Arcoxia contains components that control the formation of substances in the body that are responsible for the development pain syndrome and inflammatory process.

The active substance of the drug is etoricoxib. Additional components include: calcium hydrogen phosphate, magnesium stearate, microcrystalline cellulose, croscarmellose sodium.

Arcoxia prevents severe pain in the joints, is used for the course treatment of movable bone joints, acts gradually. If it is necessary to stop the attack and instantly alleviate the condition, the single dose is increased.

Indications for use: gouty arthritis in the acute phase, osteoarthritis, rheumatoid forms of joint inflammation, ankylosing spondylitis. In addition, doctors recommend using the medicine for soft tissue damage, as it relieves constant pain.

Arcoxia - potent medical device which should not be taken by people with high sensitivity to the constituent components, in the presence of polyps in the nasal sinuses, frequent bleeding(poor clotting), bronchial asthma (history), inflammatory processes in the digestive tract, intolerance to NSAIDs. Other contraindications to the use of the drug are: hypertension, vascular pathologies, cardiac, hepatic, renal failure, pregnancy, lactation, age up to 16 years.

Can Arcoxia be taken by people suffering from alcoholism?

No. Anti-inflammatory drug and alcohol are incompatible.

Dosing regimen

The medicine is taken orally, regardless of the meal. In osteoporosis, the daily dose of the drug should not exceed 60 mg per day, ankylosing spondylitis and rheumatoid arthritis - 90 mg, gouty arthritis in the acute phase - 120 mg. The daily rate and duration of treatment is prescribed by the doctor based on the patient's state of health. With pain syndrome, the average therapeutic dose is 60 mg once.

In view of the extensive list of side effects and available contraindications, Arcoxia is not recommended for use without a detailed diagnosis of the state of health. In addition, it is forbidden to increase the dosage of the drug more than 120 mg. Violation of the course of admission helps to reduce the effect of its action.

In case of an overdose or the use of a medication in the presence of contraindications, a negative reaction from the body is observed.

Side effects (consequences):

Sensory disturbances.
Ulcers on the mucous membrane of the mouth, digestive organs, vomiting, flatulence, diarrhea.
Drowsiness, dizziness, hallucinations, tinnitus, weakness.
Decrease in platelets and leukocytes, hemoglobin (hematocrit).
Bronchial spasms, shortness of breath, cough, infections respiratory organs, nose bleed.
Violations of the heart and kidneys, jumps in blood pressure, hypertensive crisis, heart attack.
Proteinuria, an infection of the bladder.
Skin itching, urticaria, weight gain, muscle cramps.

The effectiveness of Arcoxia 60 increases with the simultaneous use of acetylsalicylic acid and antiviral tablets. Full course therapy helps to eliminate all signs of joint pathology, restore blood circulation and metabolic processes in tissues. In order to consolidate the result, drug treatment should be supplemented with physiotherapy, exercise therapy.

What are the analogues of Arcoxia?

Ibuprofen, Cifecon, Dilaxa.

For safety reasons, it is not recommended to select the drug on your own. Self-medication is dangerous to health. Right choice medicines with similar therapeutic properties it is better to trust the attending physician. Otherwise, the result of the course of therapy may be unfavorable.

Arcoxia drug compatibility

Taking an anti-inflammatory drug is not recommended to be combined with Warfarin, because in the process of interaction, drugs increase the INR of prothrombin time by 13%.

Non-steroidal drugs (non-selective and selective) give negative compatibility with diuretic drugs and ACE inhibitors, since they weaken their effect. In case of problems with the organs of the urinary system, this tandem can lead to aggravation of renal failure. While taking Arcoxia with Cyclosporine or Tacrolimus, the risk of a nephrotoxic effect increases, and with Rifampicin, the amount of etoricoxib in plasma decreases by 65%.

Remember, in the process of using the drug, it is important to comply with the dosage prescribed by the attending physician, otherwise you can harm your health.

Arcoxia and alcohol

Non-steroidal anti-inflammatory drugs, as well as non-narcotic analgesics, are forbidden to be used simultaneously with alcoholic beverages. In the case of the interaction of Arcoxia 90, 60, 30, 120 with alcohol, the toxic effect of the drug increases, turning it into a poison for the body. As a result, metabolites are formed that damage the liver and ulcers on the mucous membrane of the organs. digestive tract. The higher the dosage of the active substance of the drug (etoricoxib) and the more alcohol is taken, the more pronounced side effects from the body.

Remember, from the moment alcohol enters the stomach, each cell begins to work on its utilization. If in this moment there are still drugs in the body, the load on the internal organs increases many times, which forces the liver to break down the incoming substances in an accelerated mode, to function for wear and tear.

When deciding to use alcoholic drinks in the process of undergoing anti-inflammatory therapy, it should be borne in mind that with such a load, it will not last long. In addition, alcohol destroys brain cells, which leads to oxygen starvation and shortfall nutrients respectively. As a result, coordination of movements, speech is disturbed, severe headaches occur, sleep disturbance, gastrointestinal tract work are observed, a person may be in a hallucinatory state. The liquid begins to linger in the layers of tissue. The metabolic process is disrupted and water-salt balance in the body.

People suffering from stomach ulcers or gastritis should be especially careful, since the interaction of "Arcoxia-alcohol" leads to an exacerbation of the course of the disease, which threatens with internal bleeding. In addition, this combination increases the risk of developing myocardial infarction, cardiovascular insufficiency, and hypertensive crisis.

The duration of the therapeutic effect of the active substance Arcoxia in the body is a day. Therefore, if there is a desire to drink alcohol, it is necessary to wait a safe period of time - 24 hours after the last dose of the drug.

Conclusion

Arcoxia is a non-steroidal drug intended for the treatment of inflammatory processes in the body. The drug is produced in four dosage variations (30, 60, 90, 120 mg). After entering the gastrointestinal tract, the drug begins to act within 30 minutes and retains its effect for 24 hours.

Arcoxia is used to treat gouty arthritis, primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. It has analgesic, antipyretic, anti-inflammatory effects, reduces the level of prostaglandins in areas of tissue inflammation.

The combination with alcohol makes the drinker fully responsible for the resulting consequences: flatulence, kidney failure, hypertensive crisis, heart attack, digestive tract disorders, impaired normal blood circulation. Etoricoxib, which is part of the drug, increases the load on the liver and kidneys, which triples under the influence of ethyl-containing drinks. Therefore, in the case of treatment with non-steroidal anti-inflammatory drugs, you should refrain from drinking hot cocktails during the course of therapy, otherwise you can experience the effect of the proverb from your own experience: “you treat one thing - you cripple another”.

If there is a predisposition to alcohol consumption (dependence), it is imperative to warn the doctor about this habit in advance in order to adjust the treatment regimen. Always be vigilant when we are talking about the health of a loved one.

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A few words about Arcoxia

Available in the form of tablets and ampoules with solutions. Manufacturers did not provide for the gel-like form and ointment. Tablets are made in the form of an apple.

The active substance is etoricoxib. It is a selective inhibitor with a depressant effect on prostaglandins responsible for various inflammations. In addition to the anti-inflammatory effect, etoricoxib is able to anesthetize and reduce fever. The main advantage of the drug is the absence of effects on the gastrointestinal mucosa and the processes of platelet adhesion.

The medicine should be taken orally. There are no specific conditions regarding the intake of food. If you follow the dosage indicated in the instructions, food will not affect the rate of absorption of the substance and its effect on the body.

The instructions for the drug contain more than one name of possible complications. Due to the fact that alcohol itself often gives similar negative manifestations are worth mentioning. Moreover, under the influence of alcohol side effects drugs are intensified. The drug in question has:

Pain in the head.
General weakness in the body.
Nausea and heartburn.
Bleeding from the nose.
Violation of concentration.
Influenza and others.

The interaction of Arcoxia and ethyl alcohol

The description of the drug contains information on whether Arcoxia and alcohol-containing drinks are compatible or not. Representatives from the pharmaceutical industry warn that in such situations, taking pills should be accompanied by extreme caution. However, this does not mean at all that it is permissible to drink alcohol-containing drinks at the same time. This warning only preserves the right of man to decide for himself.

The compatibility of Arcoxia and alcohol can be understood by studying in detail the list of contraindications and side effects. So, its action is a day. This suggests that within 24 hours the active substance etoricoxib will be in the body and affect various processes.
The combination of the drug with ethyl alcohol at this time can cause any negative consequences. We can assume the following complications, based on the reviews of doctors about the pills:

Poisoning the body with ethanol

From poisoning, dysfunction of all organs occurs. As soon as ethanol is in the blood, the body begins to act to destroy it. And if at the same time the effect of the drug is added, the load on the body increases several times. Although the description of the tablets does not say anything about this, it can be predicted that side effects from the tablets will be added to the destructive effect of alcohol. Such repeated stress is not easy for the body to endure. Significant interruptions are likely due to destructive processes. If to big picture add alcoholism, the consequences can be even more disastrous.

Liver dysfunction

Since in the process of taking Arcoxia, the iron experiences a double load. Metabolism medicinal substance takes place directly in it. Two processes will be carried out in the gland at one moment: the processing of the medicine and the fight against the harmful components of alcohol. A healthy organ will probably be able to work for some time without interruption. But a weak gland is likely to suffer significantly.

Cell damage in the brain

A complete supply of cells with oxygen molecules and nutrients supplied with blood is destroyed. There is intoxication with concomitant pain in the head, dizziness, impaired coordination and speech. When Arcoxia is taken together with alcoholic beverages, these negative phenomena may increase, since tablets have almost the same side effects. Hallucinations, drowsiness and confusion are also likely.

Malfunctions in the functions of the gastrointestinal tract

Under the influence of alcohol, the functioning of the gastrointestinal tract is disturbed. Arise various disorders or diarrhea. The drug in question also has similar side effects: the same thing is aggravated by nausea, bloating, exacerbations of gastritis and duodenal ulcers.

Kidney dysfunction

Manifested as a result of vigorous activity to remove the elements of the decay of ethyl alcohol. This function occurs with a complication due to the action of the drug. In list side effects there is also kidney failure from Arcoxia. Available increased likelihood aggravation of the present pathologies of the organ or triggering processes upon their occurrence.

Violation of metabolic processes

This includes water retention. The use of pills and alcohol at the same time can increase these manifestations. The drug also provokes metabolic disorders and water balance in the body, appetite.

The listed negative effects from the joint intake of pills and alcohol-containing drinks are by no means exhaustive. This can also include the likelihood of myocardial infarction, cardiovascular insufficiency, increased blood pressure. Allergies are quite common.

Therefore, combining pills and booze is a risky business. Despite the fact that the description of side effects from alcohol intake provides scant information, it does not follow from this that the simultaneous use of Arcoxia and ethyl alcohol does not pose a danger. Each person's body is unique, and the consequences will be individual. There is a possibility that a small dose of an alcoholic beverage will cause severe complications and the need for long-term treatment.

Rules for taking alcohol after Arcoxia

When taking Arcoxia, the liver is exposed to the greatest stress. Despite good reviews about it, the drug has many contraindications.

It must be remembered that directly in the liver, the substance is broken down into individual components. If you drink alcohol at the same time, the load on the gland will increase significantly, and toxic substances from alcohol will quickly spread throughout the body.

Therefore, deciding on the use of such drinks while taking the medicine, first of all, you should assess the condition of your liver. Moreover, it must be remembered that even the healthiest organ will not withstand such loads for a long time. Also, one should not forget about the duration of the drug. It is better to wait until the end of this period, and only then drink the drink. It will be more secure.

But in general, it is allowed to start taking pills only after the complete removal of ethanol from the blood. This period varies from 30 minutes to several days, and depends on the volume of the drink and the strength of the drink.

Below is information about the co-administration of Arcoxia and drinks containing ethyl alcohol.

We are allowed to accept:

18 hours before drinking alcohol and 8 hours after - for men;
one day before and not earlier than 14 hours after - women

In order to avoid health risks, it is better to give up alcohol for the entire duration of treatment.

In any case, the person himself is responsible for the consequences of taking Arcoxia along with alcohol-containing liquids. Given the enormous burden on the liver, kidneys and other organs, this is highly discouraged.

Since the doctor usually monitors the patient's blood pressure during the course of treatment, it is the responsibility of the latter to notify the doctor about the recent drinking of alcohol. After all, it has a direct effect on the level of blood pressure. The most detailed monitoring of blood pressure is carried out during the first 14 days. In addition, liver and kidney health, as well as enzyme levels, are often assessed. In this regard, any deviations from the normative values are perceived by the doctor as the result of the influence of the medication taken.

What do the doctor's say?

Reviews of doctors about Arcoxia are mostly positive. This non-hormonal remedy perfectly copes with many inflammations in the body. However, reviews about the use of the drug in conjunction with alcohol are unequivocally negative. In this case, a double blow to the liver is guaranteed, the doctors are sure.

The drug is broken down in this organ to final metabolites, therefore, it can adversely affect liver function - especially if hepatitis or other serious diseases are present.

If for any reason you have consumed Arcoxia and alcohol, take the following steps:

stop further intake of alcoholic beverages;
in the next four hours, drink as much pure water as possible;
study in detail the contraindications in the instructions for the tablets and subsequently take them into account;
in a situation of course administration of the drug, it is impossible to drink alcohol categorically for a period of three days to a month ( exact time abstinence will be determined by the doctor).

It should be remembered that regardless of the form of the drug taken, the side effects when combined with alcohol will be identical. Although, if this happened for the first time, the risk to health will be minimal, but it is better not to allow such situations. In difficult situations, you should seek the advice of a doctor.

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The composition and form of release of the drug

Biconvex tablets of an interesting apple-shaped form, film-coated - it is in this form that the Arcoxia drug is produced. Injections, solutions for oral administration, gels, ointments - these forms of the drug do not exist.

The main active ingredient of the drug is etoricoxib. By the way, the pharmacy sells tablets of different colors depending on the amount of the active substance - they can be green (60 mg etoricoxib), white (90 mg) or light green (120 mg).

Naturally, some auxiliary components are also present in the composition: magnesium stearate, calcium hydrogen phosphate, croscarmellose sodium and microcrystalline cellulose. film sheath consists of carnauba wax, hypromellose, titanium dioxide, lactose monohydrate, triacetin, aluminum varnish based on indigo carmine and, of course, basic dyes (Opadry white or green depending on the dosage).

Tablets are placed in convenient blisters of seven pieces. In a pharmacy, you can buy packages with one or three of these blisters.

Main pharmacological properties

This medicine belongs to the group of non-steroidal anti-inflammatory drugs. Etoricoxib is a substance that selectively inhibits COX-2, which, in turn, prevents the synthesis of prostaglandins, blocking the development of the inflammatory process. The drug "Arcoxia" also has a pronounced analgesic and antipyretic effect, but it does not affect the mucous membrane of the digestive system and the functioning of platelets.

After taking the drug is rapidly absorbed, its bioavailability is 100%. The maximum concentration in the blood is observed after 1 hour. The active ingredient binds to plasma proteins by more than 92%. It is excreted from the body mainly through the kidneys, and only 20% of the substances are excreted with feces.

Indications for use

When is it advisable to take Arcoxia? Its use is quite wide, as it provides a quick analgesic effect, and also allows you to eliminate the inflammatory process. However, most often the drug is prescribed to patients suffering from osteoarthritis and rheumatoid arthritis. Indications for use are also pain caused by gouty arthritis and ankylosing spondylitis. In some cases, tablets are recommended for people who have recently undergone dental surgery.

The drug "Arcoxia" (tablets): instructions for use and dosage

In no case should you use this drug on your own. Only a doctor can prescribe and tell you how to properly take Arcoxia (tablets). The manual contains only general recommendations.

The dosage generally depends on the patient's condition and the type of problem. For example, in osteoarthritis, it is most often recommended to take one tablet with a dosage of 60 mg per day, regardless of the meal. The maximum daily dose for patients with spondylitis and rheumatoid arthritis is 90 mg of the active substance. For gouty arthritis, you can take 120 mg per day. The duration of therapy is determined by the attending physician. However, the maximum allowable period treatment is 8-10 days, after which the reception should be stopped at least for a while.

With caution, the drug is prescribed to people suffering from liver failure - the daily dose in such cases should not exceed 60 mg.

Are there contraindications?

Immediately it should be said that this drug can not be taken by all categories of patients. The drug has contraindications, the list of which must be read before taking:

hypersensitivity to the components of the drug, as well as other non-steroidal anti-inflammatory drugs, especially in patients suffering from bronchial asthma and nasal polyposis;
erosive and ulcerative lesions of the mucous membrane of the digestive tract, gastrointestinal bleeding;
inflammatory bowel disease, including non-specific ulcerative colitis and Crohn's disease;
bleeding disorders, including hemophilia;
severe heart failure;
severe forms of renal and hepatic insufficiency;
severe ischemic heart disease;
period after the coronary artery bypass grafting;
persistent arterial hypertension;
children's age (the drug is not prescribed for children under 16 years of age);
pregnancy, lactation, as well as the period of pregnancy planning.

The drug also has some relative contraindications, in which therapy is possible, but only with the constant supervision of the attending physician. With caution, the drug is prescribed to patients suffering from fluid retention in the body, as well as severe somatic diseases, hypertension and diabetes mellitus. The medicine also cannot be combined with alcohol.

Side effects

Many patients ask the question of what complications can lead to taking the drug "Arcoxia". Reviews of doctors indicate that patients who took pills rarely complain of any deterioration. However, adverse reactions are possible. For example, during therapy, an allergic reaction may occur, sometimes even anaphylactic shock. Some patients noted the appearance of nausea, abdominal pain, diarrhea, bloating, belching, dry mouth.

Possible side effects also include headaches, weakness, confusion, sleep disturbances, anxiety, concentration problems, depression, blurred vision, vertigo, tinnitus.

Sometimes there are violations respiratory system, in particular cough, as well as nosebleeds. The drug can affect the cardiovascular system, causing an increase in pressure, palpitations, extremely rarely - congestion, circulatory disorders of the brain, hypertensive crisis, myocardial infarction. In some patients, the drug increases the likelihood of developing infectious diseases of the respiratory and digestive systems.

Overdose: symptoms and treatments

Is it possible to overdose the drug "Arcoxia". Reviews of doctors and statistical studies indicate that such cases have not been officially registered. Even a single dose of 500 mg of the active substance, as well as the use of small doses of the drug for three weeks, are not accompanied by serious complications. An overdose may cause an aggravation of the present side effects from the cardiovascular and digestive systems. Therapy in this case is symptomatic and is aimed at eliminating existing disorders.

Interaction with other drugs

While taking Arcoxia and anticoagulants, you need to carefully monitor the international normalized ratio (INR) - the ratio of prothrombin time this patient to the mean prothrombin time - especially in the first few days of therapy.

Simultaneous reception this medicine with large doses of acetylsalicylic acid increases the risk of ulcerative lesions of the mucous membrane of the digestive tract. Simultaneous therapy with tacrolimus and cyclosporins increases the likelihood of nephrotoxicity.

The drug can interact with some oral contraceptives, increasing the risk of developing thromboembolism, so be sure to tell your doctor about the hormones you are taking before starting therapy - they may need to be replaced.

Arcoxia tablets: analogues and substitutes

Not every patient for one reason or another is suitable for this drug. Therefore, many people are interested in the question of what can replace the drug "Arcoxia". Analogues of this tool exist, and there are quite a few of them.

For example, if we are talking about pain relief, then non-steroidal anti-inflammatory drugs such as Ibuprofen, Nurofen, Diclofenac (by the way, it is also available in the form of a gel for external use), Ketonal and many others are considered quite popular.

And if you suffer from osteoporosis and other diseases of the musculoskeletal locomotive apparatus, then you can choose another substitute. Arcoxia is often replaced by drugs such as Ostalon, Alendros, Ost, Lindron. But remember that only the attending physician can choose an analogue. Doing it yourself is strictly contraindicated.

How much does the medicine cost?

Many patients are interested in the question of how much the drug "Arcoxia" costs. The price, of course, will depend on several factors. In particular, it is necessary to take into account the city of residence, pricing policy pharmacies, manufacturer, etc.

So how much will the medicine "Arcoxia" cost? The price of a package of seven 60 mg tablets ranges from 350 to 450 rubles. Three blisters will cost about 1100 rubles. Dosage is another factor on which the cost of Arcoxia depends. Tablets of 90 mg cost about 550 rubles for seven pieces. For a package of three blisters, you need to pay about 1300-1400 rubles. Seven tablets with 120 mg of the active ingredient cost about 700 rubles.

Reviews of specialists and patients

Of course, many patients are interested in the question of what experts think about the drug Arcoxia. Reviews of doctors are mostly positive. The fact is that the pills really relieve the pain. Moreover, they inhibit the development of the inflammatory process and help normalize body temperature during fever. In addition, the pills are not as damaging to the liver and digestive system as some other non-steroidal anti-inflammatory drugs. On the other hand, not every patient can take the drug, since there are relatively many contraindications.

Patients for the most part also respond positively to the drug. This remedy actually relieves the condition and relieves soreness, while acting almost throughout the day. Most often, one tablet per day is enough, which is very convenient. Some people have contraindications or side effects, but it is worthwhile to understand that the body's reaction to certain drugs is individual. The disadvantages include the high cost, which not everyone can afford. On the other hand, one blister is usually enough for the entire course of treatment.

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In this article, you can read the instructions for using the drug Arcoxia. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Arcoxia in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Arcoxia in the presence of existing structural analogues. Use for the treatment of arthrosis and arthritis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Arcoxia- non-steroidal anti-inflammatory drug (NSAID). Selective inhibitor of COX-2, at therapeutic concentrations, blocks the formation of prostaglandins and has anti-inflammatory, analgesic and antipyretic effects. Selective inhibition of COX-2 is accompanied by a decrease in the severity clinical symptoms associated with the inflammatory process, while there is no effect on platelet function and the gastrointestinal mucosa.

Etoricoxib (the active substance of Arcoxia) has a dose-dependent effect of COX-2 inhibition, without affecting COX-1 when used in a daily dose of up to 150 mg. Arcoxia does not affect the production of prostaglandins in the gastric mucosa and the bleeding time. In the studies conducted, there was no decrease in the level of arachidonic acid and platelet aggregation caused by collagen.

Compound

Etoricoxib + excipients.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability when taken orally is about 100%. Eating does not significantly affect the severity and rate of absorption of etoricoxib when taken at a dose of 120 mg. Taking antacids does not affect the pharmacokinetics of the drug. Etoricoxib crosses the placental barrier and the blood-brain barrier (BBB). Intensively metabolized in the liver, with the participation of the cytochrome P450 isoenzyme (CYP) and the formation of 6-hydroxymethyl-etoricoxib. Excretion of etoricoxib occurs as metabolites by the kidneys. Less than 1% of the drug is excreted in the urine unchanged.

With a single intravenous administration In healthy volunteers of a labeled radioactive preparation containing etoricoxib at a dose of 25 mg, it was demonstrated that 70% of the drug is excreted by the kidneys, 20% - through the intestines, mainly in the form of metabolites. Less than 2% is found unchanged.

There are no pharmacokinetic differences between men and women.

Pharmacokinetics in the elderly (65 years and older) is comparable to that in the young, and there is no need to adjust the dose of the drug in the elderly.

The pharmacokinetic parameters of etoricoxib have not been studied in children under 12 years of age. In comparative pharmacokinetic studies, comparable data were obtained with the use of etoricoxib in the group of adolescents (from 12 to 17 years old) with a body weight of 40-60 kg at a dose of 60 mg per day, in the same age group and with a body weight of more than 60 kg - 90 mg per day , and in adults when taking 90 mg per day.

Indications

Symptomatic therapy of the following diseases and conditions:

osteoarthritis;
rheumatoid arthritis;
ankylosing spondylitis;
pain and inflammatory symptoms associated with acute gouty arthritis;
therapy of moderate and severe acute pain after dental surgery.

Release form

Film-coated tablets 30 mg, 60 mg, 90 mg and 120 mg.

Other dosage forms, whether injections in ampoules, ointment or gel, do not exist.

Instructions for use and dosing regimen

The drug is taken orally, regardless of food intake, with a small amount of water.

In rheumatoid arthritis and ankylosing spondylitis, the recommended dose is 90 mg 1 time per day. The daily dose for rheumatoid arthritis and ankylosing spondylitis should not exceed 90 mg.

The duration of use of the drug at a dose of 120 mg is no more than 8 days. The lowest effective dose should be used for the shortest possible course.

The average therapeutic dose for pain syndrome is 60 mg once.

Acute pain after dental surgery: the recommended dose is 90 mg 1 time per day. In the treatment of acute pain, Arcoxia should only be used during the acute symptomatic period, limited to no more than 8 days. The daily dose for pain relief after dental surgery should not exceed 90 mg.

In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

Side effect

epigastric pain;
nausea, vomiting;
diarrhea;
dyspepsia;
flatulence;
bloating;
belching;
increased peristalsis;
constipation;
dryness of the oral mucosa;
gastritis;
ulcer of the mucous membrane of the stomach or duodenum;
irritable bowel syndrome;
esophagitis;
ulcers of the oral mucosa;
gastrointestinal ulcers (with bleeding or perforation);
headache;
dizziness;
weakness;
taste disorder;
drowsiness;
sleep disorders;
sensitivity disorders, incl. paresthesia/hyperesthesia;
anxiety;
depression;
hallucinations;
confusion;
blurred vision;
conjunctivitis;
noise in ears;
renal failure, usually reversible when the drug is discontinued;
anaphylactic / anaphylactoid reactions, including a pronounced decrease in blood pressure and shock;
heartbeat;
increase in blood pressure;
hot flashes;
violation of cerebral circulation;
atrial fibrillation;
congestive heart failure;
hypertensive crisis;
cough;
dyspnea;
nose bleed;
bronchospasm;
swelling of the face;
skin itching;
rash;
hives;
Stevens-Johnson syndrome;
Lyell's syndrome;
infections upper divisions respiratory tract, urinary tract;
muscle cramps;
arthralgia;
myalgia;
swelling, fluid retention;
appetite changes;
weight gain;
leukopenia, thrombocytopenia;
flu-like syndrome;
pain in chest.

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history);
erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding, cerebrovascular or other bleeding;
inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
hemophilia and other bleeding disorders;
severe heart failure (2-4 functional classes according to the NYHA classification);
severe liver failure (more than 9 points on the Child-Pugh scale) or active disease liver;
severe renal failure (CC less than 30 ml / min), progressive kidney disease, confirmed hyperkalemia;
the period after coronary artery bypass grafting; diseases of peripheral arteries, cerebrovascular diseases, clinically expressed ischemic heart disease;
persistent blood pressure values exceeding 140/90 mm Hg. Art. with uncontrolled arterial hypertension;
pregnancy;
lactation period ( breastfeeding);
children's age up to 16 years;
hypersensitivity to any component of the drug.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

The use of the drug may adversely affect female fertility and is not recommended for women planning a pregnancy.

Use in children

Contraindicated in children and adolescents under the age of 16 years.

special instructions

Taking the drug Arcoxia requires careful monitoring of blood pressure. When prescribing the drug, all patients should monitor blood pressure during the first two weeks of treatment and periodically thereafter.

You should also regularly monitor liver and kidney function.

In case of an increase in the level of hepatic transaminases by 3 times or more relative to ULN, the drug should be discontinued.

Given the increased risk of developing unwanted effects with an increase in the duration of administration, it is necessary to periodically evaluate the need to continue taking the drug and the possibility of reducing the dose.

Do not use the drug simultaneously with other non-steroidal anti-inflammatory drugs.

Use the drug with caution if you drink alcohol often.

The shell of the drug Arcoxia contains lactose in a small amount, which should be taken into account when prescribing the drug to patients with lactase deficiency.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions. Patients who have experienced episodes of dizziness, drowsiness or weakness should refrain from activities that require concentration.

drug interaction

Pharmacodynamic interaction

In patients receiving warfarin, taking Arcoxia at a dose of 120 mg per day was accompanied by an increase of approximately 13% in MHO and prothrombin time. In patients receiving warfarin or similar medicinal products, MHO values should be monitored at the time of initiation of therapy or changes in the dosing regimen of Arcoxia, especially in the first few days.

There are reports that non-selective NSAIDs and selective COX-2 inhibitors can weaken the hypotensive effect of ACE inhibitors. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with ACE inhibitors. In patients with impaired renal function (for example, with dehydration or in old age), such a combination may aggravate renal failure.

Arcoxia can be used concomitantly with low doses of acetylsalicylic acid intended for prophylaxis. cardiovascular disease. However, co-administration of low-dose acetylsalicylic acid and Arcoxia may lead to an increased incidence of gastrointestinal ulceration and other complications compared with Arcoxia alone. After reaching a steady state, taking etoricoxib at a dose of 120 mg 1 time per day does not affect the antiplatelet activity of acetylsalicylic acid at low doses (81 mg per day). The drug does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

Cyclosporine and tacrolimus increase the risk of developing nephrotoxicity while taking Arcoxia.

Pharmacokinetic interaction

There is evidence that non-selective NSAIDs and selective COX-2 inhibitors can increase the concentration of lithium in plasma. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with lithium.

Two studies examined the effects of Arcoxia 60, 90 and 120 mg once daily for seven days in patients treated with once weekly methotrexate 7.5 to 20 mg for rheumatoid arthritis. Arcoxia at a dose of 60 and 90 mg had no effect on the plasma concentration (according to AUC) and renal clearance of methotrexate. In one study, Arcoxia at a dose of 120 mg had no effect on the plasma concentration (AUC) and renal clearance of methotrexate. In another study, Arcoxia at a dose of 120 mg increased the plasma concentration of methotrexate by 28% (according to AUC) and reduced the renal clearance of methotrexate by 13%. With the simultaneous appointment of Arcoxia in doses above 90 mg per day and methotrexate, it is necessary to monitor the possible occurrence of toxic effects of methotrexate.

Oral contraceptives: Taking Arcoxia at a dose of 120 mg with oral contraceptives containing 35 mcg of ethinylestradiol and 0.5 to 1 mg of norethindrone for 21 days, simultaneously or with a difference of 12 hours, increases the stationary AUC0-24 of ethinylestradiol by 50-60%. However, the concentration of norethisterone usually does not increase to clinically significant degree. This increase in the concentration of ethinylestradiol should be taken into account when choosing the appropriate oral contraceptive for simultaneous use with Arcoxia. A similar fact can lead to an increase in the frequency of thromboembolism, due to an increase in the exposure of ethinyl estradiol. No significant pharmacokinetic interaction with GCS was found.

Etoricoxib does not affect steady state AUC0-24 or digoxin elimination. At the same time, etoricoxib increases Cmax (by an average of 33%), which may be important in the development of an overdose of digoxin.

Co-administration of Arcoxia and rifampicin (a potent inducer of hepatic metabolism) resulted in a 65% decrease in plasma etoricoxib AUC. This interaction should be considered when Arcoxia is co-administered with rifampicin.

Antacids and ketoconazole (a potent inhibitor of CYP3A4) do not have a clinically significant effect on the pharmacokinetics of Arcoxia.

Arcoxia's analogues

Arcoxia has no structural analogues for the active substance.

Analogues for the therapeutic effect (remedies for the treatment of arthrosis):

Actasulide;
Alflutop;
Apranax;
Artra;
Artradol;
Artrovit;
Artrotek;
Aulin;
Brufen;
Butadion;
Veral;
Voltaren Emulgel;
Glucosamine sulfate 750;
Dexazon;
Dexamethasone Phosphate;
Diklobene;
Dicloberl;
Dicloran;
Diclofen;
Diclofenac;
Dimexide;
Diprospan;
Long;
DON;
Donalgin;
Zinaxin;
ibuprofen;
Indomethacin;
Kartilag Vitrum;
Ketonal;
Coxib;
Mesulide;
Myolastan;
Movasin;
Naproxen;
Nimesil;
Ortofena;
Piroxicam;
Rheuma gel;
Ronidase;
Rumalon;
Sabelnik Evalar;
Sanaprox;
Tenic;
Tenoctil;
Triamcinolone;
Fastum gel;
Feloran;
Flolid;
Chondramin;
Hondrolon;
Cefekon;
Gypsy;
Unium.

instrukciya-otzyvy.ru

Arcoxia tablets: indications, restrictions on admission and possible complications of therapy

By and large, the drug can be taken with acute pain, accompanied by an inflammatory process.

But in practice, Arcoxia tablets are prescribed for lesions of the musculoskeletal system:

rheumatoid, psoriatic and other types of arthritis;
progressive spondylitis (Bekhterev's disease);
osteoarthritis;
osteochondrosis;
other dorsopathies;
pain after orthopedic surgical interventions(according to international clinical studies).

Arcoxia tablets have a symptomatic effect, in other words, they stop the inflammation and the pain caused by it, but do not affect the etiology of the disease. Therefore, they are prescribed for a different period (the duration of treatment is selected individually) as part of complex therapy with cytostatics, chondroprotectors, physiotherapy procedures.

Contraindications to the appointment of the drug are the following pathologies and conditions:

individual allergic reaction to etoricoxib and auxiliary components of the drug and other NSAIDs;
pregnancy;
lactation;
children under 16 years of age (although studies have been conducted regarding the pharmacodynamics of the drug in adolescents over 12 years of age, during which no negative effects on the body have been identified);
a combination of bronchial asthma, sinus polyposis and intolerance to NSAIDs (which is extremely rare);
erosive lesions of the gastrointestinal tract, including peptic ulcer, colitis, Crohn's disease, inflammatory diseases in the acute stage, and even more so bleeding (during remission, the presence of such pathologies requires special care when taking Arcoxia inside);
blood clotting disorders;
severe heart, kidney and liver failure;
severe symptoms of coronary heart disease and atherosclerosis of the main blood vessels;
recovery after coronary artery bypass surgery (due to the risk of bleeding);
uncontrolled bouts of high blood pressure.

Arcoxia tablets are not the first drug from the so-called “coxibs” group.

Previously, the same company released the drug Rofecoxib. In clinical trials at the testing stage, the funds paid special attention to its effect on the mucous membrane of the digestive tract and were quite satisfied with the result.

However, over the course of several years of clinical practice, doctors have found that taking Rofecoxib significantly increases the risk of developing complications from of cardio-vascular system.

This led Merck Sharp & Dohme to withdraw the drug from the market in 2004 and discontinue its production. For this reason, the safety of etoricoxib (generic name Arcoxia) has been given great attention. After clinical trials, the risk of developing adverse reactions compared with that when taking the "classic" NSAID Diclofenac.

As a result of hard work and data analysis medical records hundreds of patients have come to the conclusion that Arcoxia tablets have a much lesser effect on the mucous epithelium of the digestive tract. And the risk of complications from the cardiovascular system is slightly lower than that of Diclofenac.

However, in accordance with international standards, the list of side effects includes all possible adverse reactions, even if their development is only theoretically possible.

According to the information provided by the manufacturer, tablets can lead to the following complications:

disorders of the digestive system, including pain in the epigastrium, stool disorders, flatulence, belching, erosive lesions of the oral mucosa appear extremely sharply, exacerbation of peptic ulcer is possible;
impact on functioning nervous system, which manifests itself in the form of headaches, dizziness, weakness, drowsiness, in isolated cases, anxiety and unreasonable fear, symptoms of depression were noted;
signs of complications from the sensory organs are extremely rare, however, taste disturbance and blurred vision are possible;
violations of cardiovascular activity can occur in the form of shortness of breath, tachycardia, increased blood pressure, which is reflected in the electrocardiogram, the onset of a heart attack and attacks of hypertension is theoretically possible;
from the side various departments respiratory tract, coughing is sometimes possible, nosebleeds are noted in isolated patients, and bronchospasm is extremely rare;
due to metabolic disorders, edema occurs, in some cases appetite worsens, or vice versa, weight gain occurs;
skin manifestations of a hypersensitivity reaction (rash, itching, urticaria);
Complications in the functioning of the tissues of the musculoskeletal system can make themselves felt in the form of minor cramps and pain in the muscles.

Also, taking Arcoxia is sometimes accompanied by a general deterioration in well-being (doctors call this condition a flu-like syndrome), an increased risk of developing infections of the urinary and respiratory systems. In addition, Arcoxia tablets can affect the results of a clinical blood test and liver tests, which should be taken into account when deciphering these studies.

Arcoxia: instructions for use and the possibility of combination with other medicines

Due to the peculiarities of the pharmacodynamics of the drug, to achieve a therapeutic effect, the drug can be taken only once a day.

The maximum dosage is 120 mg. This amount of Arcoxia instructions for use recommends drinking with severe pain that occurs against the background of psoriatic arthritis.

With osteochondrosis, it is necessary to take 0.6 g per day, for the treatment of rheumatoid arthritis and spondylitis, 0.9 g is prescribed once a day.

As a rule, they drink the medicine regardless of the meal. The duration of therapy in the maximum allowable amount (1.2 g) is no more than 8 days, in other cases, the duration of administration is determined by the doctor. But since all NSAIDs are intended for the symptomatic relief of acute pain syndrome, the use of Arcoxia is stopped after the disappearance of the main clinical manifestations diseases.

To simulate the symptoms of an overdose, the drug was given in a single dose of 500 mg. Another clinical study was conducted with the appointment of Arcoxia, the instructions for use of which clearly describe the method of taking the drug, in an amount of 150 mg per day for 3 weeks. During the tests, symptoms of overdose were not noted.

But doctors warn that exceeding the recommended number of tablets is fraught with unwanted reactions from the digestive and cardiovascular systems. Since there are no specific antidotes, and the removal of the drug by hemodialysis is ineffective, symptomatic therapy is carried out.

When combined with other Arcoxia drugs, the instructions for use advise taking into account the following points:

Anticoagulants. There is a slight increase in the action of these drugs, so this combination requires correction of the dosage of anticoagulants and monitoring of blood coagulation parameters.
Diuretics. When combined with Arcoxia, complications from the excretory system may occur.
Angiotensin-converting enzyme inhibitors. This NSAID weakens their hypotensive effect.
Aspirin and other drugs containing acetylsalicylic acid. Such a combination is justified for the prevention of the occurrence of pathologies of the cardiovascular system during the treatment of Arcoxia. At the same time, the combination of drugs increases the risk of erosive lesions of the mucous membrane of the digestive tract.
Immunosuppressants (Cyclosporin and Tacrolimus). Simultaneous reception with Arcoxia has a nephrotoxic effect.
lithium preparations. This NSAID can increase its concentration in the blood.
Methotrexate. The question of the combination of this drug with Arcoxia is very relevant in rheumatology, since this cytostatic agent is the first-line drug for long-term therapy of rheumatoid arthritis. After clinical trials, doctors came to the conclusion that when using medications in recommended dosages, the risk of complications is minimal, however, it is possible to increase the side effects of Methotrexate.
Oral contraceptives. The risk of developing thromboembolism increases.
Corticosteroids. There were no complications associated with the combination with Arcoxia.
Rifampicin. Reduces the rate of NSAID metabolism in the liver.
Antacids. Do not affect the bioavailability and pharmacodynamics of the main drug.

When taking Arcoxia, the instructions for use describe in detail all the combination options with other drugs. However, if you have additional questions, it is better to consult with a specialist.

Arcoxia medicine: special instructions for use

The drug is sold in every pharmacy, you can buy it without a doctor's prescription. Store at room temperature, away from children. Shelf life - 3 years from the date of production. With prolonged use (more than 8 days), Arcoxia requires monitoring of blood pressure numbers and clinical indicators of liver function. If identified major changes, the drug should be discontinued. Also, the drug is not combined with other NSAIDs.

The drug Arcoxia slightly affects the ability of the egg to fertilize, which must be taken into account by women planning a pregnancy. The drug may cause drowsiness and dizziness. This needs to be taken into account by drivers and other patients whose work is related to the speed of reaction. The shell of the tablets contains a small amount of lactose, which can adversely affect the health of patients with lactase deficiency.

Arcoxia drug: analogues, use during pregnancy, lactation and at an early age, cost

There are no analogues of the drug with the same composition on the pharmaceutical market today. To some extent, other selective cyclooxygenase type 2 inhibitors can replace Arcoxia. However, their choice is very limited.

Relative analogues of this tool are:

Nimesulide (Nimulid, Nise, Nimesil), appoint 0.1-0.2 g twice a day.
Meloxicam (Amelotex, M-Kam, Movalis), take 7.5-15 mg once a day.

According to doctors and patients, this new NSAID is very effective. It quickly relieves pain and other symptoms of the inflammatory process. According to clinical trial data, Arcoxia is much less likely to cause side effects, regardless of the duration of treatment. It also features ease of use. The cost of a package of 28 tablets is: 30 mg - 692.00, 60 mg - 1016 rubles, 90 mg - 1362 rubles.

med88.ru

Arcoxia is a turquoise film-coated tablet, biconvex, spherical in shape, with the inscription " ACX 30» from one edge and the inscription « 101 "- from another.

Tablets with a dosage of 30 mg are available in 2, 4, 7 or 14 pieces in a blister; 2, 1 or 4 such blisters in a cardboard box.
Arcoxia 60 mg tablets are available in blister packs of 7; 1 or 4 such blisters in a cardboard box.
Arcoxia 90 mg tablets are also available in blister packs of 7; 1 or 4 such blisters in a cardboard box.
Tablets with a dosage of 120 mg are available in 7 pieces in a blister; 1 such blister in a cardboard box.

pharmachologic effect

Non-steroidal anti-inflammatory agent . Electoral blocker cyclooxygenase-2.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Etoricoxib - oral selective blocker cyclooxygenase-2 .

In clinical trials, Arcoxia dose-dependently blocked cyclooxygenase-2 without suppression cyclooxygenase-1 when used at a dose of less than 150 mg per day. Etoricoxib does not inhibit gastric production or alter function platelets.

Cyclooxygenase regulates education prostaglandins . There are two forms - Cyclooxygenase-1 and Cyclookygenase-2 . The latter is considered as the main factor responsible for the production of mediators of pain, fever and inflammation. Cyclookygenase-2 involved in mechanisms ovulation, implantation and obstruction of the arterial duct , control of the functions of the nervous system and kidneys. It is also involved in the processes of scarring of ulcers.

Pharmacokinetics

Etoricoxib well absorbed when taken orally. Absolute bioavailability reaches 100%. The maximum concentration of the drug in the blood is observed one hour after ingestion on an empty stomach. When taking the drug during meals, it was not observed significant influence to the level of absorption.

92% etoricoxib binds to blood proteins. The drug is actively metabolized, less than 2% of the dose is excreted in the urine unchanged. 5 metabolites studied in humans etoricoxib . The main metabolite is 6-carboxylic acid formed during oxidation 6-hydroxymethyl . These substances are either biologically inactive or are weakly active blockers. COX-2 . None of them suppress COX-1 . 70% of the drug is excreted in the urine, about 25% in the feces. The half-life is 22 hours.

Pharmacokinetics in elderly patients (over 65 years of age) is identical to that in younger patients and does not depend on gender.

Pharmacokinetics The drug has not been studied in children under 12 years of age. Safety and efficiency of use etoricoxib have not been proven in children.

Indications for use Arcoxia

Indications for the use of the drug:

symptomatic treatment , ankylosing spondylitis, accompanied by inflammatory symptoms and pain;
short-term therapy for moderate acute pain after dental surgery;
acute arthritis .

Deciding on the appointment of an electoral blocker COX-2 should be taken into account all individual risks for the patient.

Contraindications

Arcoxia is contraindicated:

when to the active substance, to any other substance in the composition of the drug or to other non-steroidal anti-inflammatory drugs ;
with an active ulcer or bleeding from the stomach or intestines;
during lactation and pregnancy;
with severe liver damage (blood albumin less than 25 g / l);
people with kidney creatinine clearance less than 30 ml/min;
children under the age of 16;
people with inflammatory bowel disease;
at heart failure with congestion;
patients with whose blood pressure is constantly more than 140/90 mm Hg. Art.;
at ischemic heart disease , pathology of peripheral arteries or other cardiovascular diseases.

Side effects

The purpose of the drug can cause the following side effects:

From the side of the central nervous system: in less than 10% of cases - dizziness, headache, weakness; in less than 1% of cases - drowsiness, sleep disturbances, taste disturbance, anxiety, concentration disorders, hyperesthesia, depression, in less than 0.01% of cases - hallucinations, confusion.
From the digestive system: in less than 10% of cases - pain in the upper abdomen, , , nausea, flatulence; in less than 1% of cases - belching, bloating, increased peristalsis, dryness of the mucous membranes of the mouth, gastric mucosa or duodenum , esophagitis , ulcers of the oral mucosa, vomiting; in less than 0.01% of cases - ulcers of the stomach and intestines with perforation or bleeding.
From the side of the liver: in less than 0.01% of cases - hepatitis .
From the ENT organs: in less than 1% of cases - tinnitus, blurred vision, vertigo .
From the side of immunity: in less than 0.01% of cases - including hard fall pressure and shock.
From the genitourinary system: in less than 1% of cases -; in less than 0.01% of cases - reversible kidney failure .
From the respiratory system: in less than 1% of cases - shortness of breath, cough, nosebleeds; in less than 0.01% of cases - bronchospasm .
From the side of the cardiovascular system: in less than 10% of cases - palpitations, increased blood pressure; in less than 1% of cases - cerebrovascular accident, tides , ECG changes; in less than 0.01% of cases - hypertensive crisis .
Infections: in less than 1% of cases - infections of the urinary tract, respiratory tract.
From the skin and subcutaneous tissue: in less than 10% of cases - ecchymosis ; in less than 1% of cases - swelling of the face, itching, rash; in less than 0.0 1% of cases - Stevens-Johnson syndrome , Lyell's syndrome .
Metabolic disorders: in less than 10% of cases - edema; in less than 1% of cases - changes in appetite.
From the musculoskeletal tract: in less than 1% of cases - arthralgia , convulsions , myalgia .
Other: often - flu-like syndrome ; infrequently - pain in the chest.
Changes in clinical analyzes: in less than 10% of cases - an increase in transaminases; in less than 1% of cases - a decrease hematocrit , increased activity creatine phosphokinase, hyperkalemia, downgrade thrombocytopenia, leukopenia, increase creatinine serum, uric acid; in less than 0.01% of cases - an increase in sodium in the blood.

Instructions for use Arcoxia (Method and dosage)

Instructions for use Arcoxia prescribes to take this medicine inside, not taking into account food intake. After swallowing an Arcoxia tablet, take it with water.

When: the recommended dose is 60 or 30 mg of the drug once a day.
Ankylosing spondylitis and : Take Arcoxia 90mg tablet once a day.
Acute gouty arthritis : in the acute period, the dose of the drug is 120 mg once a day. The duration of use of the drug Arcoxia at a dose of 120 mg should not exceed 8 days.

Overdose

No overdose of Arcoxia was reported during trials.

If an overdose condition nevertheless develops, undesirable symptoms from the stomach and intestines, kidneys and cardiovascular system may appear. Treatment is symptomatic. Etoricoxib not released during hemodialysis.

Interaction

Lithium. Non-steroidal anti-inflammatory drugs and inhibit excretion lithium with urine, increasing its level in the blood.

. When used simultaneously etoricoxib and methotrexate it is necessary to monitor the increase in the toxic effect of the latter.

Oral contraceptives . Joint reception with oral contraceptives may delay their elimination, and as a result increase the incidence of side effects ( thromboembolism veins).

. Etoricoxib enhances toxic effects digoxin .

Simultaneous use etoricoxib and rifampicin leads to a decrease in the content of etoricoxib in the blood by 65%.

Antacids . Have no significant effect on pharmacokinetics of etoricoxib .

Terms of sale

It is dispensed strictly according to the prescription.

Storage conditions

Store below 30 degrees. Keep away from children.

Best before date

Three years. Do not use after the expiration date.

special instructions

Reception Arcoxia requires constant monitoring of blood pressure. All patients in the appointment of this drug should monitor blood pressure during the first 14 days of treatment. It is also recommended to regularly monitor the indicators of the condition of the kidneys and liver.

In the event of an increase in the level liver enzymes three times or more relative to normal level the drug must be discontinued.

Given the increased risk of side effects due to increased duration of administration, it is necessary to regularly evaluate the need to extend the use of Arcoxia and the possibility of reducing the dose.

It is forbidden to use the drug together with others non-steroidal anti-inflammatory drugs .

The shell of the drug contains lactose in a small amount - this should be taken into account when prescribing Arcoxia to patients with lactose intolerance .

During treatment, special care must be taken when driving and engaging in potentially hazardous activities that require concentration and speed of psychomotor reactions. Persons with a history of episodes of dizziness, weakness, should refrain from such activities.

Arkoksia's analogues

Coincidence in the ATX code of the 4th level:

The only analogue of Arcoxia containing etoricoxib is Exinef (Spain/Netherlands). Preparations with a similar structure and effects of the active substance:, Dynastat , and others. The price of analogs in most cases is lower than the price of Arcoxia.

children

The drug is prohibited for use in children under 16 years of age.

Alcohol compatibility

You should stop taking alcohol for the period of treatment with the drug.

During pregnancy and lactation

Application etoricoxib and other inhibitors COX-2 not recommended for pregnant women, women planning pregnancy and breastfeeding.

If a woman becomes pregnant during the treatment period, the drug must be discontinued.

Use in the last trimester of pregnancy may result in suppression of uterine contractions and early closure. ductus arteriosus .

Women who use etoricoxib should not breastfeed.

Reviews about Arcoxia

Medical portals and forums abound with reviews about Arcoxia. In general, the reviews of doctors and patients about these tablets are the same: almost 100% effectiveness when using the drug and a fairly high number of reports of side effects. Also, many complain about the rather high cost of the drug.

Arcoxia price

In Russia, tablets with a dosage of 120 mg (7 pieces) will cost 530-600 rubles, the price of Arcoxia 90 mg (7 pieces) is 380-410 rubles, the price of Arcoxia 60 mg (7 pieces) is 300-330 rubles. Buying 7 tablets of such a drug in Ukraine will cost an average of 121 hryvnia for 120 mg, 114 hryvnia for 90 mg and 88 hryvnia for 60 mg.

Internet pharmacies in Russia Russia
Internet pharmacies in Kazakhstan Kazakhstan

WER.RU

Arcoxia tablets 30 mg 28 pcs.Merck & Co. [Merck & Co.]

Arcoxia tablets 120 mg 7 pcs.Merck & Co. [Merck & Co.]

Arcoxia tablets 60 mg 14 pcs.Merck & Co. [Merck & Co.]

Europharm * 4% discount with promo code medical11

Arcoxia 30 mg 28 tablMerck Sharpand Dohme B.V./Frosst I

Arcoxia 60 mg 28 tabl

Arcoxia 90 mg 7 tablFrosst Iberica S.A./Merck Sharp & Dome B.V

Arcoxia 60 mg 14 tabl

Arcoxia 120 mg 7 tablFrosst Iberica S.A./Merck Sharp and

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Arcoxia

Pharmacy IFK

Arcoxia

Arcoxia Merck Sharp & Dohme, The Netherlands

Arcoxia Merck Sharp & Dohme, The Netherlands
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Author-compiler:- doctor, medical journalist Speciality:Surgery, Traumatology, Oncology, Mammology

Education: Graduated from Vitebsk State medical University majoring in Surgery. At the university, he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Work in the general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Work as a pharmaceutical representative for a year in the Rubicon company.

He presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works won prizes in the republican competition-review of student scientific works(categories 1 and 3).

NOTE! Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Arcoxia surely consult with the attending physician.

Love, 60 years old | 11:24 | 23.10.2017

I don’t know how long it will last. Now I’m injecting chondrogard. The doctor said that this is a replacement for teraflex. I tried to drink it, at least once a year.

Tatyana | 3:58 | 29.11.2016

Advised by a friend. Thank you! After taking 3 tablets of 7 - 60 mg, acute pain in the spine and legs began to go away. I drank all 7 and it became much better, I would like to drink more, but they say more than 7 is impossible. The only side effect is sleep, after 10-15 minutes after taking it, it turned off, so I took it at night. I want to say that any drug is individual. And it has nothing to do with America, Russia, Ukraine, etc.

This drug belongs to modern medicinal products, designed to take into account the shortcomings of the previous generation. Any medication not only improves the well-being of a person in a certain area of the body, but also negatively affects the vital organs of a person, so the drug developers have made every effort to reduce the number of side effects.

The main active component of the drug is etoricoxib, which is part of the group of non-steroidal anti-inflammatory components. Due to the fact that Arcoxia acts purposefully on the area of inflammation, the total number of adverse reactions is reduced, and the main manifestations of the inflammatory process ( pain, puffiness, fever) disappear very quickly.

IMPORTANT!!! Among the drugs developed for the treatment of pathologies of the musculoskeletal system, this medication is considered the safest for the patient's health.

So, Arcoxia has the following effect on the affected area of the musculoskeletal system:

anti-inflammatory;
antipyretic;
anesthetic.

Forms of release, composition and mechanism of work

The pharmaceutical product is sold in the form of tablets of 60 mg, 90 mg and 0.12 g. It is worth noting that other types, whether it be ointment, suppositories or injections in ampoules, are absent from the drug. The active component of the drug "Arcoxia" is etoricoxib, the therapeutic effect of which is the ability to suppress the activity of the COX-2 enzyme.

As a result, the metabolism of omega-6-unsaturated fatty acids is disrupted and the level of prostaglandins in the focus of inflammation decreases. Thus, the medicine stops the pain impulse, eliminates the stiffness of the joints, which usually worries people in morning time, and returns the person to the previous physical activity.

The best chondroprotectors for arthrosis of the knee joint and others: classification, prices

A healthy knee joint is a finely tuned biological machine in which mechanical movements carried out through a clear balancing of processes different nature. One of the leading roles belongs to biochemical processes, in particular, the processes of destruction and synthesis of articular cartilage proceed at the same speed.

If, as a result of some reasons, this balance is disturbed, the process of destruction can become the main one. Dystrophic and degenerative processes in cartilage tissues are observed, which is accompanied by severe pain, impaired motor function, and in the future can lead to its destruction and joint deformity.

This disease is called arthrosis. To treat this condition, substances are needed that can protect and restore destroyed articular cartilage.

Such substances exist and are called chondroprotectors. According to statistics, arthrosis most often affects the knee joint.

Classification of fondroprotectors

The principles underlying the classification of chondroprotectors may be different. The most commonly used division is based on which active substances are used in a given preparation.

You can select drugs based on:

Glucosamine is a substance that directly contributes to the synthesis of cartilage and neutralizes almost all substances that harm its tissues.
Chondroitin sulfate is a high molecular weight compound found in connective tissue animals. Basically, it is found in cartilage either in a free form, or is part of the intra-articular fluid. Its function is nutrition and cushioning in the joint. Chondroitin affects the exchange of phosphorus and calcium in cartilage, it stimulates collagen synthesis, providing tissue elasticity, and also inactivates enzymes that destroy cartilage.

Hyaluronic acid is a polysaccharide contained in the intercellular space, some tissues and body fluids, in particular, intraarticular fluid. One of its most important features is the ability to bind and hold a large number of water molecules. To perform its shock-absorbing function, the synovial fluid must have a certain viscosity value, which ensures hyaluronic acid, and also it reduces the sensitivity of pain receptors inside the joint.
Combined, containing more than one active ingredient. They have a much more pronounced therapeutic effect than monopreparations.

Another principle of classification of chondroprotectors is based on the concept of generations of chondroprotectors. Usually there are three generations:

The first generation includes drugs made from animals and raw materials.
By the second generation - allocated in pure form glucosamine, chondroitin sulfate and hyaluronic acid.
The third - chondroprotectors of a new generation, include drugs that have a combination of active substances. This includes not only glucosamine, chondroitin and hyaluronic acid, but vitamins, fatty acids and various substances are added that provide additional effectiveness of chondroprotectors in the treatment of knee arthrosis.

Features of treatment with chondroprotectors

At present, the most widespread medical practice received second-generation chondroprotectors for joints. Their application has some peculiarities.

Treatment of osteoarthritis of the knee joint (gonarthrosis) with chondroprotectors has maximum effectiveness at stages 1 or 2 of arthrosis, but if the joint is already deformed or the cartilage is completely destroyed, chondroprotectors will not help.

With osteoarthritis of the knee, a person consults a doctor in a state where the knee joint hurts a lot when walking and at rest, it can swell. At this time, the main task is to relieve the patient of pain as soon as possible, providing him with an acceptable quality of life.

In such a situation, chondroprotectors will not help, because for all their remarkable advantages, the speed of exposure is not their strong point. In the acute phase of arthrosis, non-steroidal anti-inflammatory drugs are often prescribed:

Diclofenac;
Piroxicam;
Indomethacin;
Ketoprofen;

Butadion;
Nimulid;
Celebrex;
Meloxicam.

How can cervical osteochondrosis be cured

Joint pain - treatment with folk remedies. Diseases of the joints, ligaments and muscles general concept- rheumatic diseases. This disease can manifest itself in various ways.

The most common: arthrosis (changes in joints), arthritis (inflammation of the joints), rheumatism, gout, muscular rheumatism. Osteoarthritis is most often the wear and tear of the joints caused by age, in which the joints swell slightly and ache when exerted.

Additional Help during treatment:

Relieves pain and swelling in the joints with arthritis and arthrosis
Restores joints and tissues, effective for osteochondrosis

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Chlamydial arthritis is one of the most common types of post-infectious arthropathies. This disease is associated with previous chlamydial urethrogenital infection and ranks first (seventy percent) in frequency of occurrence among reactive arthropathies (ReA).

For a long time, it was believed that chlamydial infection only triggers an abnormal immune response and provokes an inflammatory process. However, in recent times microscopic examination of the joint effusion became possible allocation the causative agent is chlamydia.

Etiology of the disease

Purchasing funds

Arcoxia is available in the form of tablets with different dosages of the active substance. This distinction allows you to unify the use of the drug: depending on the severity of the symptoms, the dosage of the remedy is also selected.

As studies of a pharmaceutical product show, its optimal use looks like this:

tablets containing 60 mg of the active substance should be used to relieve pain in patients diagnosed with osteoarthritis. Such pills are green in color;
rheumatoid arthritis and ankylosing spondylitis not only provoke strong pain symptoms, but also significantly limit the mobility of the joints. Arcoxia with 90 mg of etoricoxib in one tablet, which is distinguished by white color, effectively stops inflammation, reduces pain and returns the joy of movement;
gouty arthritis, manifesting itself as acute sudden attacks, requires the appointment of a maximum dosage of etoricoxib in an amount of 120 mg per pill. As studies show, improvement is observed already four hours after taking a tablet, painted in a light green tint.

IMPORTANT!!! Even with an established diagnosis, it is strictly forbidden to prescribe this drug to yourself: the decision to take Arcoxia and its dosage is made only by the attending physician.

When co-administered with ACE inhibitors, it is possible to weaken the hypotensive effect of ACE inhibitors. With impaired renal function, this combination can lead to further aggravation of functional renal failure.

READ ALSO: Gymnastics for the knees with arthrosis video

With the simultaneous use of Arcoxia with warfarin or similar drugs at the beginning of therapy and with each change in the dosing regimen of the drug, prothrombin time and INR (international normalized ratio) should be monitored.

Arcoxia is a modern remedy that treats inflammatory diseases of the musculoskeletal system. The drug contains etoricoxib, which is the active ingredient.

This medicine belongs to the group of non-steroidal anti-inflammatory drugs. But, if you compare it with analogues, it has many advantages, and therefore is rapidly gaining popularity.

Also in the composition of the drug there are other auxiliary components.

The active substance reduces swelling, fever, pain. Its action is directed directly to the focus of inflammation. The drug has a narrow focus, so the list of side effects is reduced as much as possible, which cannot be said about the drugs in this group.

On sale you can find a tablet form of the drug, which has different dosage.

It is not recommended to independently engage in dose selection, as this should be done by a specialist.

Not always a specific drug is suitable for a person. But this does not mean that treatment should be stopped. In this case, the doctor prescribes an analogue. What remedy is suitable instead of the drug Arcoxia? There are many analogues of it, so the doctor will be able to choose the right drug.

If the purpose of using Arcoxia was pain relief, but this remedy is not suitable for a person, then it is worth replacing it with other non-steroidal anti-inflammatory drugs. For this purpose, Ibuprofen, Diclofenac or Nurofen are suitable. There are many other similar drugs.

If a person suffers from osteoporosis or other diseases of the musculoskeletal system, then the doctor will give preference to other drugs if Arcoxia is not suitable. Analogues of the remedy are such drugs as Alendros, Ostalon and others.

This medicine is for oral use. Its intake does not depend on food intake. Given the nature of the pathology, the doctor is determined with daily dosage drug. After a person swallows a pill, it should be washed down with water, which will help to dissolve faster in the stomach, which will speed up the onset of the drug.

It must be remembered that the doctor determines the dosage, taking into account the specifics of the disease.

The instructions for use contain the following information regarding the administration of the drug:

If a person has osteoarthritis, then he needs to use 0.03-0.06 g of medication per day.
If the patient has experienced rheumatoid arthritis or Bechterew's disease, then he is prescribed 0.09 g of the drug. It should be noted that such diseases are characterized by an inflammatory process in the spinal zone and joints.
Arcoxia is also prescribed for gout. With such a disease, the exchange of uric acid is disturbed in a person, various organ lesions appear. During medical therapy, the doctor prescribes 0.12 g of this medicine if the symptoms are in acute stage. But it is worth remembering that such treatment should not last longer than a week.
If a person has acute pain, then he needs to use 0.06 g of the medicine at a time. The same dose is prescribed for people who have liver failure.
This remedy is prescribed after an operation related to dentistry. In this case, a single dose with a dosage of 0.09 g is necessary.

When administered orally, the absorption of the drug occurs in the organs of the digestive tract, while the bioavailability of the drug (that is, the ability of the drug to be absorbed) reaches 100%. Pre-meal has little effect on the absorption of Arcoxia.

The use of Arcoxia requires caution when used simultaneously with the following drugs (does not require discontinuation of these drugs):

indirect anticoagulants (Warfarin) - frequent monitoring of INR and prothrombin index is necessary;
ACE inhibitors - it is possible to reduce the antihypertensive effect of the latter;
other NSAIDs - possible aggravation of side effects on the gastrointestinal tract;
immunosuppressants (Uiklosporin, Tacrolimus) - can enhance the nephrotoxic effect of the drug.

Due to the presence of data on the passage of etoricoxib through the placenta, the use of Arcoxia is contraindicated during pregnancy and during lactation. Clinical studies do not provide data on the use of the drug in children under 12 years of age.

Arcoxia is available in tablets, 7 pieces in a blister of 30, 60, 90 and 120 mg of the active ingredient, average price in the Russian Federation is 530 rubles for 60 mg / 7 tab.

The medicine should be stored in a place protected from sunlight, at room temperature, away from children.

When buying, you must present a prescription from your doctor for this drug.

Arcoxia is a non-steroidal anti-inflammatory drug (NSAID). It has such pronounced effects as: analgesic, anti-inflammatory, antipyretic.

Reviews of patientsReviews of doctorsConclusion

Arcoxia is available in tablet form. Prescribe a drug for the treatment of diseases such as:

ankylosing spondylitis (Bekhterev's disease);
rheumatoid arthritis;
osteoarthritis;
acute pain after dental surgery;
arthritis in gout.

Consider the reviews of patients taking this drug, as well as specialists.

Reviews of patients about the drug Arcoxia

“My doctor miscalculated when he prescribed me Arcoxia to reduce joint pain, I have arthrosis. The drug appears to increase blood pressure. So my acquaintance with Arcoxia ended in a hypertensive crisis. I switched back to the proven diclofenacs. With the stomach, of course, trouble, but the pressure does not jump.

“I was in a lot of pain hip joints I struggled with this problem for 6 months. All to no avail, only the pain intensified.

I was very surprised when a young doctor prescribed me Arcoxia, which I had never even heard of. Just a few days of taking this drug began to make my life much easier.

I can’t say that the pains disappeared instantly, but they all gradually disappeared. I didn't notice any side effects."

Kseniya

“I was treated with this drug for about 10 days (although the course was prescribed for 1 month). Of course, the joint pains are gone, but the side effects exceeded all expectations. Terrible edema appeared, and not only on the legs, but also on the arms and face. Blood pressure also jumped 160/100 mm Hg. (although my usual pressure was 100/70 mmHg). With all this, the appetite disappeared, the liver increased.

To put it mildly, the side effects were much more than the therapeutic effect. The dose was quite small, only 60 mg per day. In general, immediately stopped treatment. I have not taken the drug for 5 days, but the swelling still persists, and the pressure is still high - 130/80 mm Hg. (sometimes 140/80 mm Hg).

Yes, one more unpleasant moment is high price medicines."

“The doctor of medical sciences appointed me Arcoxia. Since I have Bechterew's disease, I need to take the drug constantly. I started with a dose of 90 mg per day, was treated for more than a year. Now the doctor has allowed to reduce the dose to 60 mg per day. Fortunately, this medicine helps me very well. I somehow don’t notice anything from the side effects, though my wife says that my face is a little swollen. ”Vladimir

READ ALSO: Painkillers for arthrosis - Orthopedist.info

In order to deal with the many drugs that are offered for the treatment of arthrosis of various joints, you need to understand what happens in the body with this disease. Wherever osteoarthritis manifests itself (maybe in knee joint, ankle, hip or in the joints of the hands), the disease will proceed one by one general principle.

The active ingredient in Arcoxia is etoricoxib. In addition to it, the medication contains auxiliary components. The tablets are coated and available in 30, 60, 90 and 120 mg etoricoxib. This allows you to choose the option of a remedy for relieving symptoms of different intensity.

Are there injections and ointment with Arcoxia? No, this drug has only one form of release - tablets. Also, the drug does not contain analogues in which the active substance is etoricoxib.

How does Arcoxia work?

The drug is included by pharmacologists in the group of highly selective inhibitors of cyclooxygenase-2. Arcoxia inhibits the activity of this enzyme, thereby leading to a decrease in the level of prostaglandins in both inflammatory tissues and nerve fibers. As a result, the drug relieves pain and fever, reduces the intensity of inflammation.

Many people who first encountered the problem of joint pain find themselves helpless in front of it, because they do not know what to do and how to treat the disease.

However, today there are very effective anti-inflammatory drugs for arthrosis and arthritis, which can affect the underlying cause of the pathology and the condition of the joints in different ways.

I would like to immediately warn those patients who are in no hurry to seek help from a doctor, but prefer to diagnose and treat the disease on their own. Any self-medication can bring irreparable harm to the entire body.

You need to take only those medicines that the doctor has prescribed.

Nonsteroidal drugs for joint diseases

Non-steroidal anti-inflammatory drugs (NSAIDs, NSAIDs) are the most effective in arthrosis and arthritis of any origin. The main task of these drugs is to influence the focus of inflammation in the joints and eliminate pain.

Unlike corticosteroids ( hormonal drugs), NSAIDs do not contain hormones, which reduces the amount side effects on the body.

What are the most effective anti-inflammatory drugs for joint diseases? What are their benefits, and is there any harm from them? How do these drugs affect the disease and condition of the joints, as well as the body as a whole? We will talk about this in this article.

How to use the drug

Arcoxia is designed to help eliminate inflammatory processes in the articular and bone tissue patient, expressed in severe pain and fever in the area of the lesion. As the instructions for the use of the drug indicate, the drug quickly and effectively stops the manifestations of the inflammatory process, while practically not affecting the mucous membrane of the gastrointestinal tract.

Therefore, Arcoxia is prescribed for the following diseases and pathologies:

rheumatoid arthritis: a systemic ailment, exact reasons which have not yet been fully identified. It manifests itself in the defeat of the connective tissue of small joints (hands, feet), is characterized by a rapid transition to chronic form and frequent relapses. The main causes of the disease are injuries left without medical attention, acute respiratory viral diseases and infectious lesions of internal systems;
polyarthritis: an acute inflammatory process that usually affects several joints at the same time. It is more often caused by an infectious inflammatory process, metabolic disorders in the body, trauma or autoallergy (intolerance of one's own tissues);

The choice of the optimal dosage, the regimen of administration and the duration of treatment is determined only by the specialist who prescribed the medicine to the patient. It is strictly forbidden to make any adjustments to this scheme on your own, therefore, when undesirable consequences taking the medicine, stop drinking and immediately consult a doctor.

If the drug is not suitable for a person, the doctor will replace it with an analogue or select other medicines.

In the event that the treatment is satisfactory, Arcoxia is taken as follows: the tablets are washed down with plenty of water, without chewing or crushing. It is allowed to break the pill in half, if for some reason the patient is not able to swallow it whole.

IMPORTANT!!! The medicine is taken regardless of the meal, but studies show that the pill drunk on an empty stomach acts much faster.

Reception is carried out once a day, preferably at the same time (permissible backlash - no more than one hour). The duration of therapy should not be more than eight days, since the drug has a strong effect on the body.

The recommended treatment regimen depends on the disease diagnosed in the patient. So, with osteoarthritis, you need to take one tablet with a minimum dosage (60 mg) or half of it - it depends on the severity of the symptoms.

Rheumatoid arthritis and spondylitis imply a dosage of 90 mg, one pill per 24 hours is also enough. The highest dosage of the drug (120 mg) is recommended for gouty arthritis acute form, but regardless of the strength of the pain, taking more than one tablet per day is contraindicated.

If the final diagnosis has not yet been established, and the patient complains of acute pain in the joint, it is allowed to prescribe Arcoxia in an average or maximum dosage to eliminate unpleasant phenomena. Once the disease is identified, the doctor will be able to adjust the treatment or leave it unchanged.

To prevent the development of inflammation in the presence of chronic diseases of the musculoskeletal system, a course of treatment with a minimum dosage is usually prescribed. Interruptions in treatment and the frequency of preventive measures are determined by specialists on an individual basis.

If treatment is prescribed to a person suffering from pathologies of the cardiovascular system, the duration of the drug should be as short as possible in order to reduce the risk of possible complications.

The treatment regimen is the same for representatives of all age categories; elderly patients do not need to reduce it.

Arcoxia tablets are intended for oral use with or without food. The drug is washed down with a small amount of water.

osteoarthritis: 60 mg once a day (maximum daily dose is 60 mg);
rheumatoid arthritis and ankylosing spondylitis: 90 mg once a day (the maximum daily dose is 90 mg);
acute gouty arthritis: 120 mg once a day (maximum daily dose is 120 mg);
with pain syndrome, the average therapeutic dose is 60 mg once.

When using Arcoxia at a dose of 120 mg, the duration of treatment should not exceed 8 days. It is recommended to use the drug in the minimum effective dose for the shortest possible course.

To eliminate acute pain after dental surgery, etoricoxib 90 mg is prescribed once a day for no more than 8 days (the maximum daily dose is 90 mg). In hepatic insufficiency, the maximum daily dose should not exceed 60 mg.

The drug is taken once a day.

Having studied the information about the drug and having consulted a doctor, you can safely proceed to treatment. The therapeutic course depends on the diagnosis and individual characteristics human body.

A drug used to relieve pain, intoxication syndrome and has a moderate antipyretic effect. Widely used in therapeutic practice.

Arcoxia is a highly selective anti-inflammatory drug. It belongs to modern, highly active agents and is used for any type of inflammation.

It has a pronounced anti-inflammatory property and is used in many human diseases. Due to the rare occurrence of side effects, it is the drug of choice and is easier to tolerate by patients with diseases of the gastrointestinal tract.

The composition of the drug

This is not a single drug. In its composition there are several substances that help it to be better absorbed and more effectively manifest its anti-inflammatory properties.

The composition includes:

Main- etoricoxib 90 mg.
Auxiliary- calcium hydrogen phosphate, magnesium stearate, microcrystalline cellulose.

The unique composition of the cream is a source of important building blocks for the joints. Effective in the fight against many diseases of the joints.

Ideal for both prevention and treatment at home. Possesses antiseptic properties. Relieves swelling and pain, prevents the deposition of salts.

Release form

Produced in tablet form. Tablets are round, convex on both sides. Arcoxia tablets are available in a carton box, 4 blisters, 7 tablets each.

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It has the following properties:

Relieves pain syndrome
Promotes cartilage regeneration
Effectively relieves muscle hypertonicity
Fights swelling and eliminates inflammation

pharmachologic effect

Arcoxia - does not differ in the principle of action from other NSAIDs and is characterized by a number of clinical properties:

Nonspecific anti-inflammatory effect, which affects any kind of inflammation, regardless of its cause.
Combines several features namely, anti-inflammatory effect, antipyretic and analgesic.
Fairly well tolerated the human body.
Slows down the process clumping of platelets.
Arcoxia reduces the process biological oxidation, thereby preventing the products of cell decay from strengthening inflammatory response and spread to other systems.
This contributes to a better oxygen supply and an improvement in the metabolic picture.
Decrease in production biologically active substances, reduces the toxic effect of inflammation and improves metabolism.
Disrupts the conduction of nerve impulses thereby reducing pain.
Decreased platelet aggregation, improves blood circulation in tissues, preventing stagnation and saturating ischemic areas with oxygen.

Arcoxia- inhibits cyclooxygenase, with the help of which a large number of inflammatory mediators - prostaglandins - are released in the body.

They affect the focus of inflammation, dilating blood vessels and increasing the focus of hyperemia and edema. Reinforce pain sensitivity by acting on pain receptors.

Influences the cellular mechanisms of inflammation, inhibits the migration of biologically active amines to the focus of inflammation. Slightly changes the physico-chemical properties of cells, thereby increasing their resistance to pathogenic effects.

Indications for use

Has extensive indications for use. Due to its properties, arcoxia is used in various medical fields.

Indications can be divided into a number of systems:

Rheumatic diseases: acute rheumatic fever, rheumatoid arthritis in the acute phase, ankylosing spondylitis, gout.
Non-rheumatic diseases: osteoarthritis, osteochondrosis, myositis, trauma.
neuropathic diseases: radiculopathy, tunnel syndromes, lumbago and sciatica, cervicalgia and brachialgia, thoracalgia, intercostal neuritis and neuropathy.
Various painful syndrome.
Renal and hepatic colic.
fever syndrome.

The drug is used depending on the severity of the clinical picture and primary laboratory parameters.

Stories from our readers!
“I ordered a cream for myself for prevention and for my mother for the treatment of joints. Both were completely delighted! The composition of the cream is impressive, everyone has long known how useful, and most importantly, how effective bee products are.

After 10 days of use at my mother's constant pain and the stiffness in the fingers subsided. My knees stopped bothering me. Now this cream is always in our house. Recommended."

Instructions for use

The drug should be taken under the strict supervision of the attending physician and if the condition worsens, stop taking it. Arcoxia, taken with or without food and washed down enough liquids.

The average single dose is 90 mg. The maximum daily dose is 120 mg. The drug is used once a day, the duration of admission should not exceed 8 days

Side effects

Long-term use of Arcoxia can cause a number of undesirable reactions from various organs and their systems.

The most common side effects include:

Dyspeptic disorders gastrointestinal tract.
Formation of erosions and ulcers in the antrum of the stomach.
Increased bleeding ulcers stomach and duodenal head.
analgesic nephropathy.
acute renal failure, due to increased nephrotoxicity.
Development of anemia and thrombocytopenia.
Coagulopathy.
Toxic hepatitis.
At the appearance of at least one of these conditions, you should immediately consult a doctor.

Overdose

Cases of overdose have not been documented. The drug at the maximum dosage did not have a significant toxic effect. With prolonged use, symptoms associated with a disorder of the gastrointestinal tract and the cardiovascular system may appear.

With symptoms of drug intoxication its reception should be stopped and symptomatic therapy should be carried out. Seek medical attention immediately.

Interaction with other drugs

Care should be taken when prescribing Arcoxia in combination with other dosage forms.

She has properties boost and lower pharmacological influence other groups of drugs.
Reduces efficiency diuretics, in the form of an insufficient effect on renal filtration and renal blood flow.
Reduces the effectiveness of antihypertensive drugs and in some cases increases blood pressure.
Significantly reduces blood clotting while taking anticoagulants.
Increases the risk of side effects when taken with certain antibacterial agents.
Increases clinical effect with the simultaneous use of hypoglycemic drugs. Increases the period of stay in a hypoglycemic coma.
When taken along with sedatives enhances the analgesic effect.

Arcoxia is often co-administered with other medicinal products and therefore the risk/benefit ratio of this drug should be considered.

special instructions

When taking this drug blood pressure should be closely monitored.
Make control over the function of the kidneys and the renal apparatus.
Monitor lab results liver and with their increase, you should stop taking arcoxia.
Do not use at the same time with him other NSAIDs.
Refrain from driving and other activities that require a lot of concentration.

Use during pregnancy and lactation

The drug is strictly contraindicated during the period of gestation. It crosses the placenta and has an inhibitory effect on fetal development. Data for the mutagenic and teratogenic effects of the drug have not been received.

The drug passes through the mother's breast milk to the child. Negatively affects the development of the child during his growth

Analogues and substitutes

There are no analogues according to the molecular formula.

Substitutes are drugs from this group, but with a different active ingredient:

Diclofenac.
Ketorolac.
Paracetamol.
Metamizole sodium.
Ibuprofen.
Meloxicam.
Nimesulide.
Piroxicam.
Indomethacin.

All these drugs have the same pharmacological effect and are actively used in therapeutic practice.

Contraindications

The use of the drug is prohibited in people with certain systemic diseases of the internal organs.

The main contraindications are:

Erosions and ulcers of the stomach and duodenum.
Ulcerative diseases of the intestine.
Drug intolerance to drugs from the aspirin series.
Aspirin bronchial asthma.
Acute bronchospasm in history.
Malignant arterial hypertension.
Terminal stage of chronic heart failure.
The final stage of chronic renal failure.
Diseases associated with impaired blood clotting.
Acute bleeding.

All contraindications must be considered for adequate therapy and, if present, refuse to take the drug.

Do not use the drug as a self-medication. The need for use, dosage and contraindications are established by the attending physician.

While taking the drug, it is necessary to monitor clinical condition and regularly take general therapeutic blood tests to avoid adverse effects.

Arcoxia is a drug that is prescribed to a patient by a doctor in order to stop the inflammatory process and remove pain.

In this article, you will learn everything you need about this drug, namely: its full characteristics, methods of application, contraindications, drug compatibility with others. The article also indicates the side effects of the drug arcoxia. And if you are interested in analogues of this drug, then you will find the list in the article.

This article will be relevant to everyone who has been prescribed this drug and you want to know more about it than the doctor told you about it or what is written in the instructions is not enough for you. The article also contains videos that you will find useful to watch.

Arcoxia

Arcoxia belongs to a group of drugs that block the production of prostaglandins in inflamed tissues and the formation of arachidonic acid. The drug helps to stop inflammation, reduce temperature and pain.

This cyclooxygenase-2 inhibitor is a member of the non-steroidal group. Arcoxia has no effect on platelets and gastrointestinal mucosa if the daily dose is less than 150 mg, and at the same time it depresses the feeling of stiffness and pain. The release of the product takes place in the form of tablets, there can be no other type (injectable solutions, gels, ointments, etc.), since the manufacturer does not provide for such modifications.

The pill has a coating in the form of a film of various shades: white, light green, rich green or turquoise. The shape resembles an apple with its biconvex outline. The active substance of the drug, called etoricoxib, is contained in tablets in different quantities: 30 mg; 60 mg; 90 mg; 120 mg.

Information about the amount of the component is indicated on each pill, along with the name of the drug in full (ARCOXIA) or abbreviated form (ARC). Tablets are packed in blisters of 7 pieces per plate, the number of which in a carton varies from 1 to 4. The drug is sold through pharmaceutical outlets and pharmacies strictly according to the prescription of the attending physician.

The storage temperature for Arcoxia should not exceed 30⁰С and then its shelf life will be 3 years. The drug is prescribed for the treatment of rheumatoid arthritis, osteoarthritis, pain and inflammation during acute gouty arthritis, as well as after dental surgery.

Arcoxia is for oral use (by swallowing tablets). Food has no influence on the process of absorption of the substance and the effectiveness of its action, therefore, tablets can be taken both before and after, and even during meals, observing the prescribed dosage. The drug is quickly and almost completely absorbed in the gastrointestinal tract and its active element - etoricoxib - localized in the liver, undergoes an intensive metabolic process. Only 1% of metabolites (intermediate metabolic products) is excreted from the body with urine, the rest is to be excreted through the kidneys.

The drug Arcoxia cannot be prescribed if there are the following contraindications: individual intolerance to any of the constituent elements of the drug; liver disease; kidney failure; bleeding, erosion or ulcer in the gastrointestinal tract; hemophilia or other blood disease; hyperkalemia; increased blood pressure. In addition, the use of the drug is strictly prohibited during the period after coronary artery bypass grafting, pregnancy and breastfeeding, and until the age of 16.

Due to the increase in risks with long-term use of Arcoxia, the entire period of treatment (including the patient's well-being and the results of the drug's effect) is controlled only by the attending physician. In the first two weeks it is very important to constantly check the level of blood pressure, then it can be done a little less often, but still necessary. Also, a regular check of the condition of the liver and kidneys is a mandatory measure of control by the specialist who carries out the treatment.

This is carried out in order to timely determine the effectiveness of the course of treatment, its duration and possible occurrence deterioration in organ function. Due to the ability of the active component of Arcoxia to penetrate the placental barrier, doctors recommend that women not take this drug during the planning period of pregnancy.

In addition, the elderly, smokers, patients with diabetes mellitus, patients suffering from high blood pressure, who, while taking this kind of medication, are at risk of developing various side effects and worsening their health in general. Contraindicated in patients with diabetes mellitus.

If other drugs are taken for a long period, this should not be silent, since the doctor is responsible for health and is obliged to check the compatibility of all drugs taken with those that he prescribes. It is not allowed to take Arcoxia together with other medicines belonging to the same non-steroidal group of anti-inflammatory drugs.

Regarding motorists, the drug can reduce attention, concentration, speed of response to various situations. If at least one of these symptoms occurs, you need to inform the specialist who deals with such treatment.

Compatibility of drugs with Arcoxia

Before taking Arcoxia, it is necessary to warn your doctor about the use of other medications. The result of the interaction of Arcoxia with Warfarin is an increase in the INR (International Normalized Ratio) of prothrombin time by 13%.

Therefore, monitoring the level of this indicator is a mandatory measure to determine the effectiveness of the course of treatment. When taking non-selective and selective non-steroidal drugs, it is worth remembering their weakening effect on the effectiveness of diuretic drugs, ACE inhibitors. If at the same time the function of the kidneys is also impaired, then such a combination of drugs entails an aggravation of renal failure.

The simultaneous use of Cyclosporine or Tacrolimus with Arcoxia increases the risk of a nephrotoxic effect. Doctor prescribing to simultaneous reception Acetylsalicylic acid (often for the prevention of cardiovascular diseases) and NSAIDs, necessarily indicates the dosage of one and the other drug.

Since the use of these drugs in excess of the permitted daily dose leads to an increase in the likelihood of ulcers in the gastrointestinal tract and other side effects caused by taking Arcoxia.

With the combined use of the drug with oral anticoagulants, a change in prothrombin time was noted. Blood clotting parameters should be monitored regularly with the combined use of etoricoxib and oral anticoagulants.

The drug, with simultaneous use, may slightly reduce the effectiveness of diuretic and antihypertensive drugs. The combination of these drugs enhances the nephrotoxic effect; patients with impaired renal function are not prescribed the combined use of etoricoxib with diuretics and antihypertensive drugs.

The drug can be used in combination with acetylsalicylic acid in a daily dose of up to 81 mg. The use of the drug with higher doses of acetylsalicylic acid and other non-narcotic analgesics is contraindicated due to an increased risk of developing stomach ulcers. The drug, when combined with tacrolimus and cyclosporins, may increase their negative effects on the kidneys.

The drug, when combined, increases plasma concentrations of lithium, estrogen (including those in oral contraceptives and hormone replacement therapy), and also slightly increases plasma concentrations of digoxin.

The drug can change the pharmacokinetic parameters of methotrexate, if necessary, combined use should monitor the level of methotrexate in plasma and, if necessary, adjust its dose.
The drug is recommended to be used with caution in combination with drugs, the metabolism of which occurs with the participation of sulfotransferase. Plasma concentrations of the drug are reduced with simultaneous use with rifampicin.

pharmachologic effect

Arcoxia is an analgesic and anti-inflammatory drug of the group of highly selective cyclooxygenase-2 inhibitors. The drug has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action of the drug is based on its ability to inhibit the activity of the cyclooxygenase-2 enzyme, as a result of which the metabolism of arachidonic acid is disturbed and the level of prostaglandins in the affected tissues and tissues of the nervous system decreases.

The drug blocks the generation and inhibits the conduction of the pain impulse. In patients with diseases of the musculoskeletal system, the drug reduces morning stiffness, improves joint mobility, reduces the intensity of the inflammatory process and relieves pain. The therapeutic effect of the drug develops within 24 minutes after oral administration.

After oral administration, the active component of the drug is well absorbed into the systemic circulation. The bioavailability of the drug is 100%, the peak plasma concentration of the drug is observed 1 hour after oral administration on an empty stomach and 2 hours after taking the drug simultaneously with food intake. Etoricoxib is characterized by a high degree of binding to plasma proteins (up to 92%), in animal studies the drug penetrated the hematoplacental and blood-brain barrier.

It is metabolized in the liver, excreted mainly by the kidneys as metabolites, about 20% of the drug is excreted by the intestines as a metabolite, no more than 1% is excreted by the kidneys unchanged. The half-life reaches 22 hours.

Equilibrium concentrations of the drug are reached on the 7th day of drug therapy. Patients with impaired liver function have an increase plasma concentrations etoricoxib due to a decrease in its metabolism. In patients with severe renal impairment, there is an increase in the half-life of the drug.

Indications for use

Inside, 1 time per day. The lowest effective dose should be used for the shortest possible course. Recommended doses - 60-120 mg / day. In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

The drug is used to treat patients suffering from diseases of the musculoskeletal system, which are accompanied by pain, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, as well as acute and chronic myalgia.

The drug is intended for oral use. The film-coated tablet is recommended to be swallowed whole, without chewing or crushing, with a sufficient amount of liquid. The therapeutic effect of the drug develops faster when taking the drug on an empty stomach, but the tablet can be taken regardless of the meal. The duration of the course of treatment and the dose of the drug is determined by the attending physician individually for each patient.

Adults with osteoarthritis are usually prescribed 30 mg of the drug 1 time per day. The maximum daily dose for osteoarthritis is 60 mg. Adults with rheumatoid arthritis and ankylosing spondylitis are usually prescribed no more than 90 mg of the drug 1 time per day. Adults with acute rheumatoid arthritis are usually prescribed no more than 120 mg of the drug 1 time per day. Adults with acute pain syndrome are usually prescribed no more than 120 mg of the drug 1 time per day. Adults with chronic pain syndrome are usually prescribed no more than 60 mg of the drug 1 time per day.

When using the drug at a dose of 120 mg 1 time per day, the duration of the course of treatment should not exceed 8 days.
The drug should be used in the minimum effective doses for as long as possible short term.
Elderly patients and patients with impaired renal function with a creatinine clearance of more than 30 ml / min dose adjustment is not required.

Patients with mild hepatic impairment should not be given more than 60 mg once daily. Patients with moderately severe renal impairment should not prescribe the drug at a dose of more than 60 mg 1 time in 48 hours (it is possible to prescribe the drug at a dose of 30 mg 1 time per day).

There are no pharmacokinetic differences between men and women. Pharmacokinetics in the elderly (65 years and older) is comparable to that in young people. There is no need to adjust the dose of the drug in the elderly. Racial differences do not affect the pharmacokinetic parameters of etoricoxib.

Liver disease: in patients with mild hepatic impairment (5-6 points on the Child-Pugh scale), a single dose of etoricoxib at a dose of 60 mg / day was accompanied by a 16% increase in AUC compared with healthy individuals.

In patients with moderate hepatic impairment (7-9 points on the Child-Pugh scale), who took the drug at a dose of 60 mg every other day, the AUC value was the same as in healthy individuals who took the drug daily at the same dose. Data from clinical and pharmacokinetic studies in patients with severe hepatic impairment (more than 9 points on the Child-Pugh scale) are not available.

Renal disease: Pharmacokinetic parameters of a single dose of etoricoxib at a dose of 120 mg in patients with moderate to severe kidney disease and with terminal stage chronic renal failure (CRF) on hemodialysis did not differ significantly from those in healthy individuals. Hemodialysis had little effect on excretion (dialysis clearance - about 50 ml/min).

Use in children: The pharmacokinetic parameters of etoricoxib have not been studied in children under 12 years of age. In comparative pharmacokinetic studies, comparable data were obtained with the use of etoricoxib in the group of adolescents (from 12 to 17 years old) weighing 40-60 kg at a dose of 60 mg / day, in the same age group and weighing more than 60 kg - 90 mg / day, as well as the same in adults when taking 90 mg / day.

The drug is not used for the treatment of women during pregnancy. When prescribing the drug to women of childbearing age, pregnancy should be excluded, and reliable contraception should be used during drug therapy. If you are planning or becoming pregnant, you should stop taking the drug. If it is necessary to use the drug during lactation, you should consult with your doctor and decide on the abolition of breastfeeding.

Side effects

When using the drug in patients, the development of such side effects was noted: from the gastrointestinal tract and liver: nausea, vomiting, pain in epigastric region, indigestion, heartburn, stool disorders, increased levels of hepatic transaminases, gastroenteritis, changes in appetite. In isolated cases, the development of dryness of the oral mucosa, stomatitis, esophagitis, hepatitis and ulcerative lesions of the stomach and duodenum was noted.

From the side of the central and peripheral nervous system: dizziness, headache, disturbed sleep and wakefulness, fatigue, anxiety, emotional lability, hallucinations, paresthesia, convulsions.

From the side of the cardiovascular system and the hematopoietic system: edema of the extremities, increased blood pressure, arrhythmia, angina pectoris, anemia, leukopenia, thrombocytopenia. In isolated cases, the development of myocardial infarction, hypertensive crisis and stroke was noted.

From the side laboratory indicators: increased levels of urea nitrogen, creatinine and potassium in blood plasma, hyponatremia.

Allergic reactions: skin rash, itching, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, anaphylactic shock.

Others: blurred vision, conjunctivitis, tinnitus, cough, infectious diseases of the respiratory and urinary tract, myalgia, asthenia. In isolated cases, the development of acute renal failure and impaired liver function was noted.

Very often >10%, often -1-10%; infrequently - 0.1-1%; rarely - 0.01-0.1%; very rarely - less than 0.01%, including isolated cases.

From the digestive system: often - epigastric pain, nausea, diarrhea, dyspepsia, flatulence; infrequently - bloating, belching, increased peristalsis, constipation, dryness of the oral mucosa, gastritis, ulcer of the mucous membrane of the stomach or duodenum, irritable bowel syndrome, esophagitis, ulcers of the oral mucosa, vomiting; very rarely - gastrointestinal ulcers (with bleeding or perforation). From the hepatobiliary system: very rarely - hepatitis.

From the nervous system: often - headache, dizziness, weakness; infrequently - a violation of taste, drowsiness, sleep disturbances, a violation of sensitivity, incl. paresthesia / hyperesthesia, anxiety, depression, concentration disorders, very rarely - hallucinations, confusion.

From the senses: infrequently - blurred vision, conjunctivitis, tinnitus, vertigo. From the urinary system: infrequently - proteinuria; very rarely - renal failure, usually reversible when the drug is discontinued.

Allergic reactions: very rarely - anaphylactic / anaphylactoid reactions, including a pronounced decrease in blood pressure and shock;

From the side of the cardiovascular system: often - palpitations, increased blood pressure; infrequently - hot flashes, cerebrovascular accident, atrial fibrillation, congestive heart failure, nonspecific ECG changes; myocardial infarction, very rarely - hypertensive crisis.

From the respiratory system: infrequently - cough, shortness of breath, nosebleeds; very rarely - bronchospasm.

From the side of the skin: often - ecchymosis; infrequently - swelling of the face, pruritus, rash; very rarely - urticaria, Stevens-Johnson syndrome, Lyell's syndrome. Infections: infrequently - gastroenteritis, infections of the upper respiratory tract, urinary tract.

From the musculoskeletal system: infrequently - muscle cramps, arthralgia, myalgia. Metabolic disorders: often - edema, fluid retention; infrequently - changes in appetite, weight gain. Others: often - flu-like syndrome; infrequently - pain in the chest.

results laboratory research: often - increased "liver" transaminases; infrequently - an increase in nitrogen in the blood and urine, an increase in the activity of creatine phosphokinase, a decrease in hematocrit, a decrease in hemoglobin, hyperkalemia, leukopenia, thrombocytopenia, an increase in serum creatinine, an increase in uric acid; rarely - an increase in sodium in the blood serum.

Contraindications

Increased individual sensitivity to the components of the drug and drugs of the sulfonamide group. Patients with lactase deficiency, galactosemia and malabsorption of glucose-galactose should not be given Arcoxia, as it contains lactose.

Do not prescribe the drug to patients with severe impaired liver and / or kidney function.
The drug is not prescribed to patients with peptic ulcer during the period of exacerbation, inflammatory bowel disease, and gastrointestinal bleeding.

It is contraindicated to prescribe the drug to patients with a history of the "aspirin triad" (development of bronchospasm, allergic rhinitis and Quincke's edema in response to taking non-narcotic analgesics). The drug is not used to relieve pain in patients undergoing coronary artery bypass grafting.

The drug is not used for the treatment of patients suffering from uncontrolled arterial hypertension, congestive heart failure, ischemic disease heart, as well as lesions of peripheral arteries. The drug is not used for the treatment of women during pregnancy and lactation, as well as for the treatment of children under the age of 16 due to the lack of reliable data on the safety of the use of etoricoxib in these categories of patients.

The drug should be used with caution in the treatment of patients suffering from osteoarthritis, diabetes mellitus, lipid metabolism disorders, high blood pressure, cirrhosis, as well as patients with an increased risk of perforation, ulcerative lesions or bleeding of the gastrointestinal tract.

Caution must be observed when prescribing the drug to patients with heart failure, a decrease in the functional activity of the left ventricle, dehydration, edema, as well as when prescribing the drug to elderly patients. The drug is prescribed with caution to patients whose work is related to the management of potentially dangerous mechanisms and driving a car.

Overdose

Overdose of ARKOXIA has not been reported in clinical trials. In clinical trials, ARCOXIA at single doses up to 500 mg or multiple doses up to 150 mg/day for 21 days did not cause significant toxic effects. In case of an overdose of the drug, undesirable effects from the gastrointestinal tract, cardiovascular system and kidneys may occur. In case of overdose, symptomatic therapy is carried out.

Etoricoxib is not excreted by hemodialysis, elimination of the drug by peritoneal dialysis has not been studied. When using the drug in doses exceeding the recommended ones, patients experienced an increase in the severity of side effects of etoricoxib, in particular, an increase in undesirable effects from the cardiovascular and digestive systems, as well as from the kidneys, was most often noted.

There is no specific antidote. In case of an overdose, gastric lavage, intake of enterosorbents and symptomatic therapy. Carrying out hemodialysis with an overdose of the drug is ineffective.

Arcoxia and alcohol

The question of the compatibility of alcohol with drugs a priori should be considered for each drug separately. Yet there are no drugs that are completely unaffected by alcohol intake.

It is forbidden to combine the use of alcoholic beverages with non-narcotic analgesics and non-steroidal anti-inflammatory drugs, as this increases their toxic effect on the human body, turning it into a kind of poison. As a result, there is a risk of ulceration in the gastrointestinal tract and the formation of metabolites that damage the liver.

That is why alcohol and medicines cannot be compatible, although the question of the compatibility of alcohol and medicines worth studying in more detail. One reading of the instructions attached to the product is often not enough, it is necessary, as in the case of taking several medications in parallel, to consult with your doctor.

Regarding the use of alcohol during the course of treatment with the Arcoxia drug, the manufacturer's instructions warn that the medicine should be taken with extreme caution. Does this fact allow you to drink while you are medication in the body, in particular in the blood?

Doubtful statement. The manufacturer, using this wording, implied the existence of a person's freedom of choice and, of course, his own responsibility for his actions. It is important to remember that alcoholic beverages still have a toxic effect on the body as a whole. From the moment alcohol enters the bloodstream, each cell works to remove it (utilize it).

Considering the presence of medicines in the body at this time, the internal organs receive an enormous load. There is also an increased risk of side effects from Arcoxia. The manifestation of various malfunctions in the work of the body as a result of the launch of various destructive processes also becomes possible.

During the course of drug treatment with Arcoxia, the liver is subjected to a heavy load, since it is in it that all the metabolic processes of the drug take place. Alcoholic beverages put an additional burden on this organ, spreading their toxic effects throughout the body.

When deciding on the use of alcohol, it is necessary to take into account the state of the liver, since with such a load, even an absolutely healthy organ will not last long. In addition, drinking alcohol-containing substances has a certain kind of effect on the brain, in particular its cells. There are disturbances in the supply system of the brain through the blood. He does not receive the necessary amount of nutrients and oxygen.

The toxic effect of alcohol is manifested through headache, dizziness, loss of coordination of movement, impaired speech. If there is also a medicine in the blood, then the symptoms are greatly enhanced, since the drug allows for the possibility of the same side effects. In addition, there is a risk of manifestation of sleep disorders, disorientation, hallucinatory state.

Often, due to the use of alcohol, disorders of the gastrointestinal tract, such as diarrhea or other disorder, occur. When taking Arcoxia, in addition to this, there is the possibility of nausea, bloating and flatulence. If peptic ulcer or gastritis is observed, then in this case they can become aggravated.

The work of the kidneys, as part of the body that removes metabolites of drugs, is significantly complicated by the influence of the drug taken and the alcoholic substance. Therefore, there is a risk of worsening the condition of an already diseased organ or provoking the manifestation of one of the dangerous side effects - renal failure.

In addition, alcohol consumption contributes to metabolic process in the body, retaining fluid in the layers of tissue. Taking the drug only exacerbates this symptomatology with swelling. various parts body, while disturbing the appetite and water-salt balance. The result of the interaction of Arcoxia and alcohol can also be the occurrence of cardiovascular insufficiency, myocardial infarction, hypertensive crisis, and sometimes an allergic reaction.

special instructions

In case of an increase in the level of hepatic transaminases by 3 times or more relative to ULN, the drug should be discontinued. Given the increased risk of adverse effects with increasing duration of administration, it is necessary to periodically evaluate the need to continue taking the drug and the possibility of reducing the dose.

Do not use the drug simultaneously with other non-steroidal anti-inflammatory drugs. Use the drug with caution if you drink alcohol often. The shell of the drug Arcoxia contains lactose in a small amount, which should be taken into account when prescribing the drug to patients with lactase deficiency.

Influence on the ability to drive vehicles and control mechanisms

Analogues

Arcoxia has no structural analogues for the active substance. Analogues for the therapeutic effect (remedies for the treatment of arthrosis):

Actasulide;
Alflutop;
Apranax;
Artra;
Artradol;
Artrovit;
Artrotek;
Aulin;
Brufen;
Butadion;
Veral;
Voltaren
Emulgel;
Glucosamine sulfate 750;
Dexazon;
Dexamethasone Phosphate;
Diklobene;
Dicloberl;
Dicloran;
Diclofen;
Diclofenac;
Dimexide;
Diprospan;
Long;
DON;
Donalgin;
Zinaxin;
ibuprofen;
Indomethacin;
Kartilag
Vitrum;
Ketonal;
Coxib;
Mesulide;
Myolastan;
Movasin;
Naproxen;
Nimesil;
Ortofena;
Piroxicam;
Rheuma gel;
Ronidase;
Rumalon;
Fastum gel;
Feloran;
Flolid;
Chondramin;
Hondrolon;
Cefekon;
Gypsy;
Unium.

Source: alcoholgolu.net; vidal.by; pharmprice.kz medgid.org.ua; lsgeotar.ru; analogist.ru"

megan92 () 2 weeks ago

Tell me, who is struggling with pain in the joints? My knees hurt terribly ((I drink painkillers, but I understand that I am struggling with the effect, and not with the cause ...

Daria () 2 weeks ago

I struggled with my sore joints for several years until I read this article by some Chinese doctor. And for a long time I forgot about the "incurable" joints. So it goes

megan92 () 13 days ago

Daria () 12 days ago

megan92, so I wrote in my first comment) I will duplicate it just in case - link to professor's article.

Sonya 10 days ago

Isn't this a divorce? Why sell online?

Yulek26 (Tver) 10 days ago

Sonya, what country do you live in? .. They sell on the Internet, because shops and pharmacies set their margins brutal. In addition, payment is only after receipt, that is, they first looked, checked and only then paid. And now everything is sold on the Internet - from clothes to TVs and furniture.

Editorial response 10 days ago

Sonya, hello. This drug for the treatment of joints is really not sold through the pharmacy network in order to avoid inflated prices. Currently, you can only order Official site. Be healthy!

Sonya 10 days ago

Sorry, I didn't notice at first the information about the cash on delivery. Then everything is in order for sure, if the payment is upon receipt. Thanks!!

Margo (Ulyanovsk) 8 days ago

Has anyone tried folk methods joint treatment? Grandmother does not trust pills, the poor woman suffers from pain ...

Andrew a week ago

What kind of folk remedies I have not tried, nothing helped ...

Ekaterina a week ago

I tried to drink a decoction of bay leaves, to no avail, only ruined my stomach !! I no longer believe in these folk methods ...

Maria 5 days ago