How and how much you can take Arcoxia tablets: instructions for use. Basic pharmacological properties. Method and dosage

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university, he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Work experience: Work in the general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Work as a pharmaceutical representative for a year in the Rubicon company.

He presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works won prizes in the republican competition-review of student scientific works(categories 1 and 3).

NOTE! Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Arcoxia surely consult with the attending physician.

Love, 60 years old | 11:24 | 23.10.2017

I don’t know how long it will last. Now I’m injecting chondrogard. The doctor said that this is a replacement for teraflex. I tried to drink it, at least once a year.

Tatyana | 3:58 | 29.11.2016

Advised by a friend. Thank you! After taking 3 tablets of 7 - 60 mg, acute pain in the spine and legs began to go away. I drank all 7 and it became much better, I would like to drink more, but they say more than 7 is impossible. The only side effect is sleep, after 10-15 minutes after taking it, it turned off, so I took it at night. I want to say that any drug is individual. And it has nothing to do with America, Russia, Ukraine, etc.

To relieve inflammation and pain syndrome in the arsenal of physicians is a large number of drugs. Instructions for use will tell you about the mechanism of action and the rules for taking Arcoxia. Long-term use of many of them is accompanied by various complications. The greatest preference in rheumatology is given to non-steroidal anti-inflammatory drugs, which have the ability to act selectively.

Arcoxia is a representative latest generation drugs in this group. It is registered for use in the medical treatment of pathologies of the musculoskeletal system in many countries of the world. Characterized high efficiency with the lowest risk of developing adverse effects.

Pharmacological properties

The effectiveness of Arcoxia is due to the main active ingredient - Etoricoxib. It is a powerful and reliable tool for pain management, incl. chronic, closely associated with the inflammatory process. According to the instructions, it is intended for oral use. Arcoxia meets all the criteria for a high performance product symptomatic therapy: gives a quick, stable result, has a convenient dosing regimen, is well tolerated by patients, does not require additional analgesics.

From which pills are prescribed to patients who suffer from rheumatic diseases for a long time and need systematic anesthesia. The drug Arcoxia has:

• Analgesic action - relieves pain associated with inflammation or damage to organs and tissues. According to the severity of pain reduction and restoration of functionality minimum dose Arcoxia is not inferior to the effect of taking maximum dose Diclofenac, Indomethacin, Naproxen, Ibuprofen, or Celebrex is significantly superior to placebo and Paracetamol. Therapeutic action drug based on Etoricoxib is noticeable in the maximum short span time, while in total less likely to cause complications from the gastrointestinal tract, which makes Arcoxia the best drug in the line of painkillers. A tangible beneficial effect is manifested within 28 minutes after application and lasts for a year after the completion of the course of treatment.

• Anti-inflammatory action - suppresses the exudative and proliferative phases, eliminating all signs of inflammation: relieves redness of the skin, feeling hot, swelling of soft tissues, joint enlargement, swelling, soreness, morning stiffness and loss of functionality. The drug demonstrates the most stable decrease in inflammatory activity, against the background of low toxicity, not inferior to the therapeutic effect of other selective and non-selective NSAIDs.

• Antipyretic effect - reduces high temperature in febrile conditions, reducing the excitability of the heat-regulating centers of the hypothalamus. It has a long antipyretic effect, which is additional - it is not used exclusively for antipyretic therapy. Arcoxia is banned in pediatrics.

Composition, release forms

The drug is manufactured by the pharmaceutical company Merck Sharp and Dome, the country of origin is Spain / the Netherlands, and MSD Pharmaceuticals is engaged in promotion and sale in Russia.

Arcoxia is available in a single dosage form - film-coated tablets. There are several types of tablets. All of them are apple-shaped, convex on both sides, the name and dosage of Etoricoxib are engraved on one edge, and 101, 200 or 202 are embossed on the other. They have the same set of components, but differ in the dosage of the main active ingredient, the dye that is part of the film shell and number of tablets per pack:

• 30 mg - blue-green, 28 pcs.;

• 60 mg - dark green, 14, 28 tablets;

• 90 mg - white, 2.7 or 28 pieces;

• 120 mg - yellow-green, 7 or 28 tablets.

The instructions indicate the composition of the auxiliary ingredients of the drug:

• calcium hydrogen orthophosphate, magnesium stearate - fillers, give the desired mass, ensure the release rate and completeness of absorption;

• microcrystalline cellulose, croscarmellose sodium - baking powder, promote rapid dissolution.

How does Arcoxia work?

The therapeutic effect of anti-inflammatory drugs is due to the suppression of the COX-2 enzyme, which is actively formed in response to tissue damage, and is responsible for the synthesis of the most important pain mediators - prostaglandins. These physiologically active substances in a certain concentration are constantly present in almost all organs and tissues. In excess, they contribute to the development and maintenance inflammatory process, pain sensations. By suppressing the production of prostaglandins in the lesion, most nonsteroidal drugs inhibit not only the pathological COX-2 enzyme, but also the physiological COX-1, violating normal processes in the body.

How long you can take painkillers, anti-inflammatory medicine - depends on its safety. To avoid negative complications (mainly from the side of the cardiovascular and digestive systems), the task of the drug is to act selectively.

Arcoxia is a highly selective inhibitor, it inhibits the pathological enzyme 106 times more strongly, therefore it is approved for long-term use. When evaluating the long-term appointment, the special MEDAL program during the studies (1.5 years of continuous use) revealed a relatively greater safety of Arcoxia.

The instructions indicate the main parameters of the pharmacokinetics of Arcoxia, ensuring the speed and completeness of the development of the effect:

• easily absorbed into the systemic circulation, bioavailability (ability to be absorbed) - 100%;

• food intake does not have a significant effect on the absorption process, the time to reach the maximum concentration on an empty stomach is 1 hour, when taken with food - 2 hours;

• 92% of the drug passes into the form associated with plasma proteins, penetrates through physiological barriers;

• actively biotransformed in the liver, 1-2% is excreted through the urinary tract unchanged;

• half-life - 22 hours, metabolites do not affect COX-1, leave the body mainly with urine, a small part - with feces;

• gender, age, body weight, race indicators do not change, renal, hepatic insufficiency affect slightly.

Indications for admission

The list of diseases - from which Arcoxia helps, is indicated in the instructions. It is important to consider that the drug is potent, but is not used to get rid of pain of any etiology, its main purpose is the treatment of rheumatic diseases.

How many days the course of treatment for Arcoxia lasts is decided by the doctor, based on the type, activity of the disease, and individual characteristics.

Numerous studies have established:

• on the 8th day of taking 120 mg / day, Arcoxia completely relieves pain in 90% of patients with gouty arthritis, the pain subsides after 4 hours;

• after 2 days of use, 90 mg significantly reduces pain, improving the quality of life of patients suffering from,. For stable clinical efficacy in osteoarthritis, a 6-week course of 60 mg of the drug or a 12-week course of 30 mg is usually sufficient;

• in dental, gynecological practice, 90 mg of medication is prescribed for pain relief for 3 days, relief comes after 30 minutes;

• for chronic lumbar pain, 60 mg of Arcoxia per day is indicated, for acute pain and during exacerbations no more than 120;

• 120 mg of Arcoxia before surgery is sufficient to reduce pain intensity for 8 hours.

Instructions for use

When prescribing Arcoxia, adhere to the rules for the minimum effective dosage for the shortest possible course. The therapeutic effect is achieved faster if you take the pill on an empty stomach, but the completeness of assimilation does not depend on the fact of eating, so taking the pill before or after eating does not really matter.

• swallow the tablets whole, without chewing and with a sufficient amount of liquid;

• with kidney dysfunction, the excretion of metabolic products is difficult, which increases the toxicity of the drug, so the doses in such patients are limited to 30 mg / day or 60 mg / 48 hours;

• with liver dysfunction, metabolism slows down - the maximum allowed dose is 60 mg / 24 hours;

• 120 mg can be taken daily only for 8 days;

• if there is no positive dynamics, you should notify the doctor and replace Arcoxia with another one;

• with long-term therapy, constant monitoring of pressure, cardiac functions is required, every 2 weeks - kidney, liver tests.

There were no cases of overdose in the study. Exceeding the permissible doses may be accompanied by indigestion, the functioning of the renal system, adverse cardiovascular events (pressure surges, arrhythmia, increased heart rate). Treatment of overdose - removal of remnants of tablets from the gastrointestinal tract, supportive therapy. There is a category of patients who are not recommended to use Arcoxia.

The instructions list the following identified contraindications:

• individual hypersensitivity to the component of the drug, the drug as a whole, other NSAIDs;

• tendency to allergic reactions;

• peptic ulcers, bleeding in the gastrointestinal tract;

• severe forms of insufficiency - renal, hepatic, cardiac;

• inflammation of the intestinal mucosa;

• ischemia, hypertension;

• intolerance to lactose, glucose, galactose, elevated level calcium in the blood;

• planning a pregnancy, pregnant, breastfeeding women;

• age 0-16 years old.

Side effects

The safety of Arcoxia directly depends on the daily and total dosage. It has been established that a dose of less than 150 mg for 3 weeks does not suppress the physiological COX-1 enzyme, does not destroy the gastric mucosa, does not cause prolonged bleeding, and does not affect platelet aggregation.

The instruction warns that in some cases the following side effects may occur:

• dizziness, migraine, distraction or anxiety, sleep problems, depression, taste disorder;

• discomfort in the upper part of the peritoneum, indigestion, defecation process, frequent loose stools, nausea, heartburn, ulcers, increased peristalsis;

• inflammation of the liver, stomach, intestines, proteinuria, diseases urinary tract, infections of the respiratory system;

• anaphylaxis, shock, a sharp decrease in pressure, bronchospasm, dyspnea, excess accumulation liquids;

• muscular, joint pain, convulsions, hemorrhages in the skin and mucous membranes, urticaria, allergic dermatitis, itching, Stevens-Johnson syndrome;

• flu-like condition, feeling of pain behind the sternum, conjunctivitis, tinnitus, impaired visual function;

• attacks of heat, chills, heart rhythm disturbances, cerebral circulation, pressure surges;

• increased hepatic transaminases, creatine kinase, changes in the blood picture.

The answer to the question: is it possible to drink alcohol during the treatment of Arcoxia, the same as in the case of others nonsteroidal drugs- the combination of analgesics with alcoholic beverages turns the medicine into a poison that damages the liver and organs of the gastrointestinal tract.

The instruction also warns whether to refrain or be careful when performing work that requires concentration and prompt response.

When taking Arcoxia concomitantly with other medications, possible drug interactions should be considered:

oral contraceptives - blockage possible blood vessel detached thrombus;

• Digoxin, Rifampicin, lithium - their content in plasma changes.

The opinion of doctors and patients

There are many reviews about Arcoxia - and from medical workers and from patients. Almost all doctors agree that the launch of Arcoxia tablets on the pharmaceutical market has opened a new milestone in rheumatology and orthopedics. This modern drug provides a quick, lasting effect, well anesthetizes, it can be prescribed to elderly patients with chronic joint diseases, incl. caused by the inflammatory process. The doctors' comments are also unanimous in assessing the safety of Arcoxia: it is well tolerated by patients, it acts gently, cases of serious side effects and intolerance are extremely rare. Doctors also respond positively to the convenient form of release with different dosages, which makes it possible to rationally approach the treatment with this expensive drug.

As civilization develops, human life expectancy increases. Against this background, the number of diseases characteristic of age-related changes in the body. Including, such as arthritis and arthrosis. The development of medicine helps to successfully cope with destructive-dystrophic and related diseases of the joints.

One of effective means in the fight against the manifestations of arthritis and arthrosis, the non-steroidal anti-inflammatory drug Arkosksia becomes. It is valid in case treatment of joint diseases any age. Inflammatory processes that affect the joints can be observed even in childhood and adolescence.

In contact with

What is Arcoxia

With all the wide choice of options for analogues, it is Arcoxia that is recognized as one of the most successful and viable options drugs for inflammatory diseases of the joints and the musculoskeletal system.

instructions for use

The active ingredient is Etoricoxib. belonging to the group of coxibs. in number pharmacological actions includes:

• anti-inflammatory;
• Painkiller;
• Antipyretic.

The main task of the drug is to inhibit the activity of COX-2 by a selective mechanism, which prevents the biosynthesis of prostaglandtins, inflammatory mediators. At the same time, the active substance does not damage the mucous membrane of the digestive tract and does not affect the functional activity of platelets.

Attention! Available in tablet form. One tablet may contain, depending on the dosage, 30,60,90, 120 mg of active substance.

Variants of drug analogues

The pharmaceutical market offers a wide range of medical preparations for the treatment of joint diseases. Among them are analogues of Arcoxia with a similar principle of operation. They can be recommended in a situation of intolerance to a drug prescribed by a doctor. Another reason for choosing to purchase analogues is the desire to purchase effective drug at a favorable price.

the drug has analogues

In the pharmacy you can find the following analogues:

• ibuprofen;
• Diclofenac;
• Lidron;
• Ketonal;
• Ostalon and many others.

In total, in a pharmacy, a pharmacist can offer more than 50 drugs that are approximately the same in terms of the principles of action.

It is impossible to choose a drug that is ready to become a replacement for Arcoxia on your own. The appointment of any remedy for the treatment of diseases of the musculoskeletal system, arthritis and arthrosis can only be done by the attending physician.

The Russian industry is currently producing a wide range of drugs, the action of which is similar, and the composition is almost identical.

In this list, Dilaxa occupies one of the leading positions in terms of popularity. The price of packaging of this option varies from 75 to 100 rubles. The package contains three active capsules.

Nise becomes an affordable analogue. Its disadvantages include a greater number of possible side effects.

Arcosia and alcohol

The combination of medicines and alcohol is not recommended at all, but there are groups of drugs, the use of which together with alcohol-containing drinks becomes dangerous to health and life. This list includes Arcoxia and alcohol. Their compatibility is not implied even in minimal dosages. The action of the drug lasts 24 hours. Recommended throughout this period avoid alcohol intake.

What can you take medicine for?

What can Arcoxia be used for? The list of diseases is quite wide. Direct indication for prescription becomes:

• Rheumatoid arthritis;
• Inflammation of the joints of various etymologies;
• Gouty arthritis with inflammation and pain;
• Surgical operations in dentistry;
• Osteoarthritis.

take with severe inflammation

Due to the high degree of anti-inflammatory effects, Arcoxia for colds with severe inflammation may be prescribed by the attending physician. A successful prospect of application in case of any inflammation is based on the readiness of the active substance to neutralize the action of cyclooxygenase. Due to this, there is a decrease in the level of formation of archidonic acid. The active substance reduces the level of prostaglandins in inflamed tissues.

Arcoxia or movalis, which is better

Often patients are faced with the suggestion of pharmacists using on par with Arcoxia Movalis.

Such a proposal by a pharmacist in the case, for example, of the absence of a prescribed medicinal substance in the assortment at a particular moment, is quite justified.

From the point of view of physicians, due to the approximately similar composition, the funds are interchangeable and equivalent. Both about belong to the type of non-steroidal anti-inflammatory drugs medicinal means.

The possibility of replacement can only be determined by the attending physician.

Instructions for use

The advantage of using this drug is the possibility of taking it without taking food into account. Available in the form of easy-to-use biconvex tablets taken orally. Wash down the drug need a little water room temperature.

The dosage of Arcoxia tablets is determined by the doctor depending on the diagnosis in which the drug is prescribed:

• In case of treatment rheumatoid arthritis the single dose is 90 mg once a day.
• Up to 120 mg per day is recommended for the treatment of acute gouty arthritis.
• Up to 90 mg per day is used in case of appointment after dental surgery.
• No more than 60 mg per day is taken for osteochondrosis and other diseases if the patient has liver failure.

The tablet should be taken with water

How many days to take the medicine, the therapist or neurologist will determine. In most cases, the duration of use is 8 days. The effectiveness of the use can only be determined by a doctor. It is possible to prolong the use of the drug. Constant use forbidden.

Important! In case of violation of the rules of admission, the patient may experience side effects.

Features of taking the drug for osteochondrosis

The drug is recommended for a wide range of inflammatory diseases. It is especially effective for arthritis, arthrosis, inflammation of the musculoskeletal system. Among the diagnoses for which the use

Arcoxia is especially useful, including osteochondrosis. It is advisable to use the cervical version of this disease. The drug contributes to a noticeable improvement in the patient's condition, in a short time relieves acute pain.

Action provides reduction of the inflammatory process.

Arcoxia side effects

in number side effects includes:

• Negative manifestations in the respiratory system, manifested in the form of shortness of breath, cough, nosebleeds, in exceptional cases, bronchospasm may be noted.
• With a negative impact on the nervous system, dizziness, confusion, weakness, taste disturbance, tinnitus are possible. In rare cases, hallucinations, impaired sensitivity can be observed.
• When side effects affect the cardiovascular system, an increased heartbeat appears, arterial blood pressure rises. Among the rare but noted manifestations, experts call congestive heart failure, atrial fibrillation, hot flashes, cerebrovascular accident.
• Muscle cramps, myalgia, arthralgia may appear.
• Required upon admission measuring the level of protein in the urine, its increase will inform about an overdose or individual intolerance.
• The drug can cause various disorders in the gastrointestinal tract, including gastritis, ulcer bleeding, belching, vomiting, bloating.

Other side effects may also occur. If you notice a deterioration in well-being while taking the drug, it is recommended to immediately seek advice from your doctor. In the presence of negative manifestations, it is recommended to apply for the appointment of analogues. Including, in such a situation, inexpensive Russian analogues that differ in affordable cost can be used.

possible side effects

Forbidden use this medicinal product and its analogues during pregnancy and breastfeeding. It is not recommended to prescribe it without the presence of a vital important indications patients under 18 years of age. Consultation with a specialist is required when prescribing for many chronic diseases. Including with severe liver damage, diseases of the gastrointestinal tract, arterial hypertension, coronary heart disease and others.

Manufacturer

This drug represents on the Russian market company from the Netherlands Merck Sharp and Dome B.V. It was founded in 1668. For the first century and a half, the company was a pharmacy, only in the second half of the 19th century the descendants of the founder began to specialize in the industrial production of medicines. The company is currently headquartered in the United States.

The trademark is a transnational corporation with representative offices in all developed countries, including Russia. In our country, the company's office is located in Moscow. The company has developed a wide range of effective medicines that are intended for the treatment of joints and bones.

Attention! Production is carried out only at the company's factories in compliance with strict quality control requirements.

Video: Arcoxia tablets instructions for use

In conclusion, it is important to pay attention to the possibility of taking only on the direct prescription of the attending physician.

Etoricoxib is a selective inhibitor of inducible cyclooxygenase (COX-2). AT therapeutic dosage inhibits the production of prostaglandins and arachidonic acid. Inhibition of enzymes involved in the biosynthesis of inflammatory mediators is accompanied by a decrease in the severity of inflammatory reactions in tissues.

According to clinical tests, Arcoxia does not affect the function of the gastrointestinal mucosa and blood plates (platelets). At the same time, etoricoxib does not affect the biosynthesis of constructive cyclooxygenase, which stimulates the transformation of arachidonic acid into prostacyclins. In the course of studies, the effect of NSAIDs on the rate of platelet aggregation provoked by collagen was not established.

The therapeutically active components of the anesthetic drug are rapidly absorbed into the bloodstream through the walls of the gastrointestinal tract. The bioavailability of etoricoxib in oral intake equal to 99-100%. The maximum rate of reaching the peak concentration of metabolites in plasma is 60 minutes when taking at least 120 mg.

Eating practically does not affect the intensity of absorption of NSAID components. The parallel use of antacids does not affect the pharmacokinetic properties of the drug.

Upon penetration into the blood, etoricoxib binds to albumin by at least 92-95%. In the case of taking 120 mg of the drug, the volume of redistribution of active substances in the equilibrium state is 125 liters. It is known that the active metabolites of NSAIDs penetrate the hematoplacental and blood-brain barrier.

Under the influence of cytochrome P450 isoenzymes, etoricoxib is metabolized in the parenchyma to 6-hydroxymethyl-etoricoxib. No more than 1% of the active substances are excreted unchanged by the kidneys. Etoricoxib is cleaved to 5 different metabolites, most of which do not affect COX-1 and have low activity against inducible cyclooxygenase.

wer.ru

Description of the drug

Arcoxia is a non-steroidal anti-inflammatory drug with antipyretic, analgesic properties. The drug belongs to the group of selective cyclooxygenesis agents. It is used to treat diseases of the articular tissue. Arcoxia contains components that control the formation of substances in the body that are responsible for the development of pain and inflammation.

The active substance of the drug is etoricoxib. Additional components include: calcium hydrogen phosphate, magnesium stearate, microcrystalline cellulose, croscarmellose sodium.

Arcoxia prevents strong pain in the joints, used for course treatment of movable bone joints, acts gradually. If it is necessary to stop the attack and instantly alleviate the condition single dose increase.

Indications for use: gouty arthritis in the acute phase, osteoarthritis, rheumatoid forms inflammation of the joints, ankylosing spondylitis. In addition, doctors recommend using the medicine for soft tissue damage, as it relieves constant pain.

Arcoxia - potent medical device, which should not be taken by people with high sensitivity to the constituent components, in the presence of polyps in the nasal sinuses, frequent bleeding (poor clotting), bronchial asthma (history), inflammatory processes in the digestive tract, intolerance to NSAIDs. Other contraindications to the use of the drug are: hypertension, vascular pathologies, cardiac, hepatic, renal failure, pregnancy, lactation, age up to 16 years.

Can Arcoxia be taken by people suffering from alcoholism?

No. Anti-inflammatory drug and alcohol are incompatible.

Dosing regimen

The medicine is taken orally, regardless of the meal. In osteoporosis, the daily dose of the drug should not exceed 60 mg per day, ankylosing spondylitis and rheumatoid arthritis - 90 mg, gouty arthritis in the acute phase - 120 mg. daily rate and the duration of treatment is prescribed by the doctor based on the state of health of the patient. With pain syndrome, the average therapeutic dose is 60 mg once.

In view of the extensive list of side effects and available Contraindications Arcoxia It is not recommended to use without a detailed diagnosis of the state of health. In addition, it is forbidden to increase the dosage of the drug more than 120 mg. Violation of the course of admission helps to reduce the effect of its action.

In case of overdose or use of the drug in the presence of contraindications, there is backlash from the body.

Side effects (consequences):

1. Sensory disturbances.
2. Ulcers on the mucous membrane of the mouth, digestive organs, vomiting, flatulence, diarrhea.
3. Drowsiness, dizziness, hallucinations, tinnitus, weakness.
4. Decrease in platelets and leukocytes, hemoglobin (hematocrit).
5. Bronchospasm, shortness of breath, cough, respiratory infections, nosebleeds.
6. Violations of the heart and kidneys, jumps in blood pressure, hypertensive crisis, heart attack.
7. proteinuria, infection Bladder.
8. Skin itching, urticaria, weight gain, muscle cramps.

The effectiveness of Arcoxia 60 increases with the simultaneous use of acetylsalicylic acid and antiviral tablets. A full course of therapy helps to eliminate all signs of joint pathology, restore blood circulation and metabolic processes in tissues. In order to consolidate the result, drug treatment should be supplemented with physiotherapy, exercise therapy.

What are the analogues of Arcoxia?

Ibuprofen, Cifecon, Dilaxa.

For safety reasons, it is not recommended to select the drug on your own. Self-medication is dangerous to health. Right choice medicines with similar therapeutic properties it is better to trust the attending physician. Otherwise, the result of the course of therapy may be unfavorable.

Arcoxia drug compatibility

Taking an anti-inflammatory drug is not recommended to be combined with Warfarin, because in the process of interaction, drugs increase the INR of prothrombin time by 13%.

Non-steroidal drugs (non-selective and selective) give negative compatibility with diuretic drugs and ACE inhibitors because they weaken their impact. In case of problems with the organs of the urinary system, this tandem can lead to aggravation of renal failure. While taking Arcoxia with Cyclosporine or Tacrolimus, the risk of a nephrotoxic effect increases, and with Rifampicin, the amount of etoricoxib in plasma decreases by 65%.

Remember, in the process of using the drug, it is important to comply with the dosage prescribed by the attending physician, otherwise you can harm your health.

Arcoxia and alcohol

Non-steroidal anti-inflammatory drugs, like non-narcotic analgesics, it is forbidden to use simultaneously with alcoholic beverages. In the case of the interaction of Arcoxia 90, 60, 30, 120 with alcohol, the toxic effect of the drug increases, turning it into a poison for the body. As a result, metabolites are formed that damage the liver and ulcers on the mucous membrane of the digestive tract. The higher the dosage of the active substance of the drug (etoricoxib) and the more alcohol is taken, the more pronounced side effects from the body.

Remember, from the moment alcohol enters the stomach, each cell begins to work on its utilization. If at the moment there are still drugs in the body, the load on the internal organs increases many times, which forces the liver to break down the substances that have arrived in an accelerated mode, to function for wear and tear.

When deciding to drink alcoholic beverages during anti-inflammatory therapy, it should be borne in mind that with such a load, it will not last long. In addition, alcohol destroys brain cells, which leads to oxygen starvation and shortfall nutrients respectively. As a result, coordination of movements, speech is disturbed, severe headaches occur, sleep disturbance, gastrointestinal tract work are observed, a person may be in a hallucinatory state. The liquid begins to linger in the layers of tissue. The metabolic process is disrupted and water-salt balance in the body.

People suffering from stomach ulcers or gastritis should be especially careful, since the interaction "Arcoxia-alcohol" leads to an exacerbation of the course of the disease, which threatens internal bleeding. In addition, this combination increases the risk of developing myocardial infarction, cardiovascular insufficiency, and hypertensive crisis.

Duration therapeutic effect active substance Arcoxia in the body - a day. Therefore, if there is a desire to drink alcohol, it is necessary to wait a safe period of time - 24 hours after the last dose of the drug.

Conclusion

Arcoxia - non-steroidal medicinal product designed to treat inflammatory processes in the body. The drug is produced in four dosage variations (30, 60, 90, 120 mg). After entering the gastrointestinal tract, the drug begins to act within 30 minutes and retains its effect for 24 hours.

Arcoxia is used to treat gouty arthritis, primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. It has analgesic, antipyretic, anti-inflammatory effects, reduces the level of prostaglandins in areas of tissue inflammation.

The combination with alcohol makes the drinker fully responsible for the resulting consequences: flatulence, kidney failure, hypertensive crisis, heart attack, digestive tract disorders, impaired normal blood circulation. Etoricoxib, which is part of the drug, increases the load on the liver and kidneys, which triples under the influence of ethyl-containing drinks. Therefore, in the case of treatment with non-steroidal anti-inflammatory drugs, you should refrain from drinking hot cocktails during the course of therapy, otherwise you can experience the effect of the proverb from your own experience: “you treat one thing - you cripple another”.

If there is a predisposition to alcohol consumption (dependence), this habit should be without fail notify the doctor in advance in order to adjust the treatment regimen. Always be vigilant when it comes to the health of a loved one.

stopalkogolism.ru

A few words about Arcoxia

Available in the form of tablets and ampoules with solutions. Manufacturers did not provide for the gel-like form and ointment. Tablets are made in the form of an apple.

As a substance active action is etoricoxib. It is a selective inhibitor with a depressant effect on prostaglandins responsible for various inflammations. In addition to the anti-inflammatory effect, etoricoxib is able to anesthetize and reduce fever. The main advantage of the drug is the absence of effects on the gastrointestinal mucosa and the processes of platelet adhesion.

The medicine should be taken orally. There are no specific conditions regarding the intake of food. If you follow the dosage indicated in the instructions, food will not affect the rate of absorption of the substance and its effect on the body.

The instructions for the drug contain more than one name of possible complications. Due to the fact that alcohol itself often gives similar negative manifestations are worth mentioning. Moreover, under the influence of alcohol, all side effects of drugs are enhanced. The drug in question has:

• Pain in the head.
• General weakness in the body.
• Nausea and heartburn.
• Bleeding from the nose.
• Violation of concentration.
• Influenza and others.

The interaction of Arcoxia and ethyl alcohol

The description of the drug contains information on whether Arcoxia and alcohol-containing drinks are compatible or not. Representatives from the pharmaceutical industry warn that in such situations, taking pills should be accompanied by extreme caution. However, this does not mean at all that it is permissible to drink alcohol-containing drinks at the same time. This warning only preserves the right of man to decide for himself.

The compatibility of Arcoxia and alcohol can be understood by studying in detail the list of contraindications and side effects. So, its action is a day. This suggests that within 24 hours the active substance etoricoxib will be in the body and affect various processes.
The combination of the drug with ethyl alcohol at this time can cause any negative consequences. We can assume the following complications, based on the reviews of doctors about the pills:

Poisoning the body with ethanol

From poisoning, dysfunction of all organs occurs. As soon as ethanol is in the blood, the body begins to act to destroy it. And if at the same time the effect of the drug is added, the load on the body increases several times. Although the description of the tablets does not say anything about this, it can be predicted that side effects from the tablets will be added to the destructive effect of alcohol. Such repeated stress is not easy for the body to endure. Significant interruptions are likely, provoked by destructive processes. If alcoholism is added to the overall picture, the consequences can be even more devastating.

Liver dysfunction

Since in the process of taking Arcoxia, the iron experiences a double load. Metabolism of the drug substance occurs directly in it. Two processes will be carried out in the gland at one moment: the processing of the medicine and the fight against the harmful components of alcohol. A healthy organ will probably be able to work for some time without interruption. But a weak gland is likely to suffer significantly.

Cell damage in the brain

A complete supply of cells with oxygen molecules and nutrients supplied with blood is destroyed. There is intoxication with concomitant pain in the head, dizziness, impaired coordination and speech. With the joint use of Arcoxia with alcoholic beverages, these negative effects may intensify, since the tablets have almost the same side effects. Hallucinations, drowsiness and confusion are also likely.

Malfunctions in the functions of the gastrointestinal tract

Under the influence of alcohol functioning gastrointestinal tract is violated. Various disorders or diarrhea occur. The drug in question also has similar side effects: the same thing is aggravated by nausea, bloating, exacerbations of gastritis and duodenal ulcers.

Kidney dysfunction

Manifested due to vigorous activity on the withdrawal of elements of the decomposition of ethyl alcohol. This function occurs with a complication due to the action of the drug. Among the side effects from Arcoxia, there is also kidney failure. Available increased likelihood aggravation of the present pathologies of the organ or triggering processes upon their occurrence.

Violation of metabolic processes

This includes water retention. The use of pills and alcohol at the same time can increase these manifestations. The drug also provokes metabolic disorders and water balance in the body, appetite.

The listed negative effects from the joint intake of pills and alcohol-containing drinks are by no means exhaustive. This also includes the risk of myocardial infarction, cardiovascular insufficiency, increased blood pressure. Allergies are quite common.

Therefore, combining pills and booze is a risky business. Although the description of side effects from the intake of alcohol, scarce information is given, it does not follow from this that the simultaneous use of Arcoxia and ethyl alcohol does not pose a danger. Each person's body is unique, and the consequences will be individual. There is a possibility that small dose alcoholic drink lead to severe complications and the need for long-term treatment.

Rules for taking alcohol after Arcoxia

When taking Arcoxia, the liver is exposed to the greatest stress. Despite good reviews about it, the drug has many contraindications.

It must be remembered that directly in the liver, the substance is broken down into individual components. If you drink alcohol at the same time, the load on the gland will increase significantly, and toxic substances from alcohol will quickly spread throughout the body.

Therefore, deciding on the use of such drinks while taking the medicine, first of all, you should assess the condition of your liver. Moreover, it must be remembered that even the healthiest organ will not withstand such loads for a long time. Also, one should not forget about the duration of the drug. It is better to wait until the end of this period, and only then drink the drink. It will be more secure.

But in general, it is allowed to start taking pills only after the complete removal of ethanol from the blood. This period varies from 30 minutes to several days, and depends on the volume of the drink and the strength of the drink.

The following is information about the co-administration of Arcoxia and containing ethyl alcohol drinks.

We are allowed to accept:

• 18 hours before drinking alcohol and 8 hours after - for men;
• one day before and not earlier than 14 hours after - women

In order to avoid health risks, it is better to give up alcohol for the entire duration of treatment.

In any case, the person himself is responsible for the consequences of taking Arcoxia along with alcohol-containing liquids. Given the enormous burden on the liver, kidneys and other organs, this is highly discouraged.

Since the doctor usually monitors the patient's blood pressure during the course of treatment, it is the responsibility of the latter to notify the doctor about the recent drinking of alcohol. After all, it has a direct effect on the level of blood pressure. The most detailed monitoring of blood pressure is carried out during the first 14 days. In addition, liver and kidney health, as well as enzyme levels, are often assessed. In this regard, any deviations from the normative values ​​are perceived by the doctor as the result of the influence of the medication taken.

What do the doctor's say?

Reviews of doctors about Arcoxia are mostly positive. This non-hormonal remedy perfectly copes with many inflammations in the body. However, reviews about the use of the drug in conjunction with alcohol are unequivocally negative. In this case, a double blow to the liver is guaranteed, the doctors are sure.

The drug is broken down in this organ to final metabolites, therefore, it can adversely affect liver function - especially if hepatitis or other serious diseases are present.

If for any reason you have consumed Arcoxia and alcohol, take the following steps:

1. stop further intake of alcoholic beverages;
2. in the next four hours, drink as much pure water as possible;
3. study in detail the contraindications in the instructions for the tablets and subsequently take them into account;
4. in a situation of a course of taking the drug, it is impossible to drink alcohol categorically for a period of three days to a month (the doctor will determine the exact time of abstinence).

It should be remembered that regardless of the form of the drug taken, the side effects when combined with alcohol will be identical. Although, if this happened for the first time, the risk to health will be minimal, but it is better not to allow such situations. AT difficult situations you should seek the advice of a doctor.

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The composition and form of release of the drug

Biconvex tablets of an interesting apple-shaped form, film-coated - it is in this form that the Arcoxia drug is produced. Injections, oral solutions, gels, ointments - these forms of the drug do not exist.

The main active ingredient of the drug is etoricoxib. By the way, the pharmacy sells tablets of different colors depending on the amount of the active substance - they can be green (60 mg etoricoxib), white (90 mg) or light green (120 mg).

Naturally, some auxiliary components are also present in the composition: magnesium stearate, calcium hydrogen phosphate, croscarmellose sodium and microcrystalline cellulose. film sheath consists of carnauba wax, hypromellose, titanium dioxide, lactose monohydrate, triacetin, aluminum varnish based on indigo carmine and, of course, basic dyes (Opadry white or green depending on the dosage).

Tablets are placed in convenient blisters of seven pieces. In a pharmacy, you can buy packages with one or three of these blisters.

Main pharmacological properties

This medicine belongs to the group of non-steroidal anti-inflammatory drugs. Etoricoxib is a substance that selectively inhibits COX-2, which, in turn, prevents the synthesis of prostaglandins, blocking the development of the inflammatory process. The drug "Arcoxia" also has a pronounced analgesic and antipyretic effect, but it does not affect the mucous membrane of the digestive system and the functioning of platelets.

After taking the drug is rapidly absorbed, its bioavailability is 100%. The maximum concentration in the blood is observed after 1 hour. The active ingredient binds to plasma proteins by more than 92%. It is excreted from the body mainly through the kidneys, and only 20% of the substances are excreted with feces.

Indications for use

When is it advisable to take Arcoxia? Its use is quite wide, as it provides a quick analgesic effect, and also allows you to eliminate the inflammatory process. However, most often the drug is prescribed to patients suffering from osteoarthritis and rheumatoid arthritis. Indications for use are also pain caused by gouty arthritis and ankylosing spondylitis. In some cases, tablets are recommended for people who have recently undergone dental surgery.

The drug "Arcoxia" (tablets): instructions for use and dosage

In no case should you use this drug on your own. Only a doctor can prescribe and tell you how to properly take Arcoxia (tablets). The manual contains only general recommendations.

The dosage generally depends on the patient's condition and the type of problem. For example, in osteoarthritis, it is most often recommended to take one tablet with a dosage of 60 mg per day, regardless of the meal. Maximum daily dose for patients with spondylitis and rheumatoid arthritis - 90 mg of the active substance. For gouty arthritis, you can take 120 mg per day. The duration of therapy is determined by the attending physician. However, the maximum allowable period treatment is 8-10 days, after which the reception should be stopped at least for a while.

With caution, the drug is prescribed to people suffering from liver failure - the daily dose in such cases should not exceed 60 mg.

Are there contraindications?

Immediately it should be said that this drug can not be taken by all categories of patients. The drug has contraindications, the list of which must be read before taking:

• hypersensitivity to the components of the drug, as well as other non-steroidal anti-inflammatory drugs, especially in patients suffering from bronchial asthma and nasal polyposis;
• erosive and ulcerative lesions of the mucous membrane of the digestive tract, gastrointestinal bleeding;
• inflammatory bowel disease, including non-specific ulcerative colitis and Crohn's disease;
• bleeding disorders, including hemophilia;
• severe heart failure;
• severe forms of renal and hepatic insufficiency;
• severe ischemic heart disease;
• the period after coronary artery bypass grafting;
• persistent arterial hypertension;
• children's age (the drug is not prescribed for children under 16 years of age);
• pregnancy, lactation, as well as the period of pregnancy planning.

The drug also has some relative contraindications, in which therapy is possible, but only with the constant supervision of the attending physician. With caution, the drug is prescribed to patients suffering from fluid retention in the body, as well as severe somatic diseases, hypertension and diabetes mellitus. The medicine also cannot be combined with alcohol.

Side effects

Many patients ask the question of what complications can lead to taking the drug "Arcoxia". Reviews of doctors indicate that patients who took pills rarely complain of any deterioration. Nonetheless adverse reactions possible. For example, during therapy, an allergic reaction may occur, sometimes even anaphylactic shock. Some patients noted the appearance of nausea, abdominal pain, diarrhea, bloating, belching, dry mouth.

Possible side effects also include headaches, weakness, confusion, sleep disturbances, anxiety, concentration problems, depression, blurred vision, vertigo, tinnitus.

Sometimes there are violations of the respiratory system, in particular cough, as well as nosebleeds. The drug can affect the cardiovascular system, causing an increase in pressure, palpitations, extremely rarely - congestion, circulatory disorders of the brain, hypertensive crisis, myocardial infarction. In some patients, the drug increases the likelihood of developing infectious diseases of the respiratory and digestive systems.

Overdose: symptoms and treatments

Is it possible to overdose the drug "Arcoxia". Reviews of doctors and statistical studies indicate that such cases have not been officially registered. Even a single dose of 500 mg of the active substance, as well as the use of small doses of the drug for three weeks, are not accompanied by serious complications. An overdose may cause an aggravation of the present side effects from the cardiovascular and digestive systems. Therapy in this case symptomatic and aimed at eliminating existing disorders.

Interaction with other drugs

While taking Arcoxia and anticoagulants, you should carefully monitor the international normalized ratio (INR) - the ratio of the patient's prothrombin time to the average prothrombin time - especially in the first few days of therapy.

Simultaneous reception this medicine with large doses of acetylsalicylic acid increases the risk of ulcerative lesions of the mucous membrane of the digestive tract. Simultaneous therapy with tacrolimus and cyclosporins increases the likelihood of nephrotoxicity.

The drug can interact with some oral contraceptives, increasing the risk of developing thromboembolism, so be sure to tell your doctor about the hormones you are taking before starting therapy - they may need to be replaced.

Arcoxia tablets: analogues and substitutes

Not every patient for one reason or another is suitable for this drug. Therefore, many people are interested in the question of what can replace the drug "Arcoxia". Analogues this tool exist, and there are many of them.

For example, if we are talking about pain relief, then non-steroidal anti-inflammatory drugs such as Ibuprofen, Nurofen, Diclofenac (by the way, it is also available in the form of a gel for external use), Ketonal and many others are considered quite popular.

And if you suffer from osteoporosis and other diseases of the musculoskeletal system, then you can choose another substitute. Arcoxia is often replaced by drugs such as Ostalon, Alendros, Ost, Lindron. But remember that only the attending physician can choose an analogue. Doing it yourself is strictly contraindicated.

How much does the medicine cost?

Many patients are interested in the question of how much the drug "Arcoxia" costs. The price, of course, will depend on several factors. In particular, the city of residence, the pricing policy of the pharmacy, the manufacturer, etc. should be taken into account.

So how much will the medicine "Arcoxia" cost? The price of a package of seven 60 mg tablets ranges from 350 to 450 rubles. Three blisters will cost about 1100 rubles. Dosage is another factor on which the cost of Arcoxia depends. Tablets of 90 mg cost about 550 rubles for seven pieces. For a package of three blisters, you need to pay about 1300-1400 rubles. Seven tablets with 120 mg active component cost about 700 rubles.

Reviews of specialists and patients

Of course, many patients are interested in the question of what experts think about the drug Arcoxia. Reviews of doctors are mostly positive. The fact is that the pills really relieve the pain. Moreover, they inhibit the development of the inflammatory process and help normalize body temperature during fever. In addition, the pills are not as damaging to the liver and digestive system as some other non-steroidal anti-inflammatory drugs. On the other hand, not every patient can take the drug, since there are relatively many contraindications.

Patients for the most part also respond positively to the drug. This remedy actually relieves the condition and relieves soreness, while acting almost throughout the day. Most often, one tablet per day is enough, which is very convenient. Some people have contraindications or side effects, but it is worth understanding that the body's reaction to certain drugs is individual. The disadvantages include the high cost, which not everyone can afford. On the other hand, one blister is usually enough for the entire course of treatment.

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In this article, you can read the instructions for using the drug Arcoxia. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Arcoxia in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Arcoxia analogues, if available structural analogues. Use for the treatment of arthrosis and arthritis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Arcoxia- non-steroidal anti-inflammatory drug (NSAID). Selective inhibitor of COX-2, at therapeutic concentrations, blocks the formation of prostaglandins and has anti-inflammatory, analgesic and antipyretic effects. Selective inhibition of COX-2 is accompanied by a decrease in the severity of clinical symptoms associated with the inflammatory process, while there is no effect on platelet function and the gastrointestinal mucosa.

Etoricoxib (the active substance of Arcoxia) has a dose-dependent effect of COX-2 inhibition, without affecting COX-1 when used in a daily dose of up to 150 mg. Arcoxia does not affect the production of prostaglandins in the gastric mucosa and the bleeding time. In the studies conducted, there was no decrease in the level of arachidonic acid and platelet aggregation caused by collagen.

Compound

Etoricoxib + excipients.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability when taken orally is about 100%. Eating does not significantly affect the severity and rate of absorption of etoricoxib when taken at a dose of 120 mg. Taking antacids does not affect the pharmacokinetics of the drug. Etoricoxib crosses the placental barrier and the blood-brain barrier (BBB). Intensively metabolized in the liver, with the participation of the cytochrome P450 isoenzyme (CYP) and the formation of 6-hydroxymethyl-etoricoxib. Excretion of etoricoxib occurs as metabolites by the kidneys. Less than 1% of the drug is excreted in the urine unchanged.

With a single intravenous injection of a labeled radioactive drug containing etoricoxib at a dose of 25 mg to healthy volunteers, it was demonstrated that 70% of the drug is excreted by the kidneys, 20% - through the intestines, mainly in the form of metabolites. Less than 2% is found unchanged.

There are no pharmacokinetic differences between men and women.

Pharmacokinetics in the elderly (65 years and older) is comparable to that in the young, and there is no need to adjust the dose of the drug in the elderly.

The pharmacokinetic parameters of etoricoxib have not been studied in children under 12 years of age. In comparative pharmacokinetic studies, comparable data were obtained with the use of etoricoxib in the group of adolescents (from 12 to 17 years old) with a body weight of 40-60 kg at a dose of 60 mg per day, in the same age group and with a body weight of more than 60 kg - 90 mg per day , and in adults when taking 90 mg per day.

Indications

Symptomatic therapy the following diseases and states:

• osteoarthritis;
• rheumatoid arthritis;
• ankylosing spondylitis;
• pain and inflammatory symptoms associated with acute gouty arthritis;
• therapy of moderate and severe acute pain after dental surgery.

Release forms

Film-coated tablets 30 mg, 60 mg, 90 mg and 120 mg.

Other dosage forms, be it injections in ampoules, ointment or gel, does not exist.

Instructions for use and dosing regimen

The drug is taken orally, regardless of food intake, with a small amount of water.

In rheumatoid arthritis and ankylosing spondylitis, the recommended dose is 90 mg 1 time per day. The daily dose for rheumatoid arthritis and ankylosing spondylitis should not exceed 90 mg.

The duration of use of the drug at a dose of 120 mg is no more than 8 days. You should use the minimum effective dose the shortest possible rate.

The average therapeutic dose for pain syndrome is 60 mg once.

Acute pain after dental surgery: the recommended dose is 90 mg 1 time per day. In the treatment of acute pain, Arcoxia should only be used during the acute symptomatic period, limited to no more than 8 days. The daily dose for pain relief after dental surgery should not exceed 90 mg.

In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

Side effect

• epigastric pain;
• nausea, vomiting;
• diarrhea;
• dyspepsia;
• flatulence;
• bloating;
• belching;
• increased peristalsis;
• constipation;
• dryness of the oral mucosa;
• gastritis;
• ulcer of the mucous membrane of the stomach or duodenum;
• irritable bowel syndrome;
• esophagitis;
• ulcers of the oral mucosa;
• gastrointestinal ulcers (with bleeding or perforation);
• headache;
• dizziness;
• weakness;
• taste disorder;
• drowsiness;
• sleep disorders;
• sensitivity disorders, incl. paresthesia/hyperesthesia;
• anxiety;
• depression;
• hallucinations;
• confusion;
• blurred vision;
• conjunctivitis;
• noise in ears;
• renal failure, usually reversible when the drug is discontinued;
• anaphylactic / anaphylactoid reactions, including a pronounced decrease in blood pressure and shock;
• heartbeat;
• increase in blood pressure;
• hot flashes;
• violation of cerebral circulation;
• atrial fibrillation;
• congestive heart failure;
• hypertensive crisis;
• cough;
• dyspnea;
• nose bleed;
• bronchospasm;
• swelling of the face;
• skin itching;
• rash;
• hives;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• infections of the upper respiratory tract, urinary tract;
• muscle cramps;
• arthralgia;
• myalgia;
• swelling, fluid retention;
• appetite changes;
• weight gain;
• leukopenia, thrombocytopenia;
• flu-like syndrome;
• pain in the chest.

Contraindications

• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history);
• erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding, cerebrovascular or other bleeding;
• inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
• hemophilia and other bleeding disorders;
• severe heart failure (2-4 functional classes according to the NYHA classification);
• severe liver failure (more than 9 points on the Child-Pugh scale) or active liver disease;
• severe renal failure (CC less than 30 ml / min), progressive kidney disease, confirmed hyperkalemia;
• the period after coronary artery bypass grafting; diseases of peripheral arteries, cerebrovascular diseases, clinically expressed ischemic heart disease;
• persistent blood pressure values ​​exceeding 140/90 mm Hg. Art. with uncontrolled arterial hypertension;
• pregnancy;
• lactation period (breastfeeding);
• children's age up to 16 years;
• hypersensitivity to any component of the drug.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

The use of the drug may adversely affect female fertility and is not recommended for women planning a pregnancy.

Use in children

Contraindicated in children and adolescents under the age of 16 years.

special instructions

Taking the drug Arcoxia requires careful monitoring of blood pressure. When prescribing the drug, all patients should monitor blood pressure during the first two weeks of treatment and periodically thereafter.

You should also regularly monitor liver and kidney function.

In case of an increase in the level of hepatic transaminases by 3 times or more relative to ULN, the drug should be discontinued.

Given the increased risk of adverse effects with increasing duration of administration, it is necessary to periodically evaluate the need to continue taking the drug and the possibility of reducing the dose.

Do not use the drug simultaneously with other non-steroidal anti-inflammatory drugs.

Use the drug with caution when frequent use alcohol.

The shell of the drug Arcoxia contains lactose in a small amount, which should be taken into account when prescribing the drug to patients with lactase deficiency.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions. Patients who have experienced episodes of dizziness, drowsiness or weakness should refrain from activities that require concentration.

drug interaction

Pharmacodynamic interaction

In patients receiving warfarin, taking Arcoxia at a dose of 120 mg per day was accompanied by an increase of approximately 13% in MHO and prothrombin time. In patients receiving warfarin or similar medicinal products, MHO values ​​should be monitored at the time of initiation of therapy or changes in the dosing regimen of Arcoxia, especially in the first few days.

There are reports that non-selective NSAIDs and selective inhibitors COX-2 may reduce the hypotensive effect of ACE inhibitors. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with ACE inhibitors. In patients with impaired renal function (for example, with dehydration or in old age), such a combination may aggravate renal failure.

Arcoxia can be used concomitantly with low doses of acetylsalicylic acid intended for prophylaxis. cardiovascular diseases. However, co-administration of low-dose acetylsalicylic acid and Arcoxia may lead to an increased incidence of gastrointestinal ulcers and other complications compared with Arcoxia alone. After reaching a steady state, taking etoricoxib at a dose of 120 mg 1 time per day does not affect the antiplatelet activity of acetylsalicylic acid at low doses (81 mg per day). The drug does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

Cyclosporine and tacrolimus increase the risk of developing nephrotoxicity while taking Arcoxia.

Pharmacokinetic interaction

There is evidence that non-selective NSAIDs and selective COX-2 inhibitors can increase the concentration of lithium in plasma. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with lithium.

Two studies examined the effects of Arcoxia 60, 90 and 120 mg once daily for seven days in patients treated with once weekly methotrexate 7.5 to 20 mg for rheumatoid arthritis. Arcoxia at a dose of 60 and 90 mg had no effect on the plasma concentration (according to AUC) and renal clearance of methotrexate. In one study, Arcoxia at a dose of 120 mg had no effect on the plasma concentration (AUC) and renal clearance of methotrexate. In another study, Arcoxia at a dose of 120 mg increased the plasma concentration of methotrexate by 28% (according to AUC) and reduced the renal clearance of methotrexate by 13%. With the simultaneous appointment of Arcoxia in doses above 90 mg per day and methotrexate, it is necessary to monitor the possible occurrence of toxic effects of methotrexate.

Oral contraceptives: Taking Arcoxia at a dose of 120 mg with oral contraceptives containing 35 mcg of ethinylestradiol and 0.5 to 1 mg of norethindrone for 21 days, simultaneously or with a difference of 12 hours, increases the stationary AUC0-24 of ethinylestradiol by 50-60%. However, the concentration of norethisterone usually does not increase to a clinically significant extent. This increase in the concentration of ethinylestradiol should be taken into account when choosing the appropriate oral contraceptive for simultaneous use with Arcoxia. A similar fact can lead to an increase in the frequency of thromboembolism, due to an increase in the exposure of ethinyl estradiol. No significant pharmacokinetic interaction with GCS was found.

Etoricoxib does not affect steady state AUC0-24 or digoxin elimination. At the same time, etoricoxib increases Cmax (by an average of 33%), which may be important in the development of an overdose of digoxin.

Co-administration of Arcoxia and rifampicin (a potent inducer of hepatic metabolism) resulted in a 65% decrease in plasma etoricoxib AUC. This interaction should be considered when Arcoxia is co-administered with rifampicin.

Antacids and ketoconazole (a potent inhibitor of CYP3A4) do not have a clinically significant effect on the pharmacokinetics of Arcoxia.

Arcoxia's analogues

Structural analogues according to active substance Arcoxia does not have a cure.

Analogues for the therapeutic effect (remedies for the treatment of arthrosis):

• Actasulide;
• Alflutop;
• Apranax;
• Artra;
• Artradol;
• Artrovit;
• Artrotek;
• Aulin;
• Brufen;
• Butadion;
• Veral;
• Voltaren Emulgel;
• Glucosamine sulfate 750;
• Dexazon;
• Dexamethasone Phosphate;
• Diklobene;
• Dicloberl;
• Dicloran;
• Diclofen;
• Diclofenac;
• Dimexide;
• Diprospan;
• Long;
• DON;
• Donalgin;
• Zinaxin;
• ibuprofen;
• Indomethacin;
• Kartilag Vitrum;
• Ketonal;
• Coxib;
• Mesulide;
• Myolastan;
• Movasin;
• Naproxen;
• Nimesil;
• Ortofena;
• Piroxicam;
• Rheuma gel;
• Ronidase;
• Rumalon;
• Sabelnik Evalar;
• Sanaprox;
• Tenic;
• Tenoctil;
• Triamcinolone;
• Fastum gel;
• Feloran;
• Flolid;
• Chondramin;
• Hondrolon;
• Cefekon;
• Gypsy;
• Unium.

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Arcoxia tablets: indications, restrictions on admission and possible complications of therapy

By and large, the drug can be taken with acute pain, accompanied by an inflammatory process.

But in practice, Arcoxia tablets are prescribed for lesions of the musculoskeletal system:

• rheumatoid, psoriatic and other types of arthritis;
• progressive spondylitis (Bekhterev's disease);
• osteoarthritis;
• osteochondrosis;
• other dorsopathies;
• pain after orthopedic surgical interventions(according to international clinical studies).

Arcoxia tablets have a symptomatic effect, in other words, they stop the inflammation and the pain caused by it, but do not affect the etiology of the disease. Therefore, they are prescribed for a different period (the duration of treatment is selected individually) as part of complex therapy with cytostatics, chondroprotectors, physiotherapy procedures.

Contraindications to the appointment of the drug are the following pathologies and conditions:

• individual allergic reaction to etoricoxib and auxiliary components of the drug and other NSAIDs;
• pregnancy;
• lactation;
• children's age up to 16 years (although studies have been conducted regarding the pharmacodynamics of the drug in adolescents over 12 years of age, during which no negative effects on the body have been identified);
• a combination of bronchial asthma, sinus polyposis and intolerance to NSAIDs (which is extremely rare);
• erosive lesions of the gastrointestinal tract, including peptic ulcer, colitis, Crohn's disease, inflammatory diseases in the acute stage, and even more so bleeding (during remission, the presence of such pathologies requires special care when taking Arcoxia inside);
• blood clotting disorders;
• severe heart, kidney and liver failure;
• severe symptoms of coronary heart disease and atherosclerosis of the main blood vessels;
• recovery after coronary artery bypass surgery (due to the risk of bleeding);
• uncontrolled bouts of high blood pressure.

Arcoxia tablets are not the first drug from the so-called “coxibs” group.

Previously, the same company released the drug Rofecoxib. In clinical trials at the testing stage, the funds paid special attention to its effect on the mucous membrane of the digestive tract and were quite satisfied with the result.

However, over the course of several years of clinical practice, doctors have found that taking Rofecoxib significantly increases the risk of complications from the cardiovascular system.

This led Merck Sharp & Dohme to withdraw the drug from the market in 2004 and discontinue its production. For this reason, the safety of etoricoxib ( generic name Arcoxia) was given great attention. After clinical trials, the risk of developing adverse reactions compared with that when taking the "classic" NSAID Diclofenac.

As a result of painstaking work and analysis of medical records of hundreds of patients, it was concluded that Arcoxia tablets have a much lesser effect on the mucous epithelium of the digestive tract. And the risk of complications from the cardiovascular system is slightly lower than that of Diclofenac.

However, in accordance with international standards, the list of side effects includes all possible adverse reactions, even if their development is only theoretically possible.

According to the information provided by the manufacturer, tablets can lead to the following complications:

• disorders of the digestive system, including pain in the epigastrium, stool disorders, flatulence, belching, erosive lesions of the oral mucosa appear extremely sharply, exacerbation of peptic ulcer is possible;
• influence on the functioning of the nervous system, which manifests itself in the form of headaches, dizziness, weakness, drowsiness; in isolated cases, anxiety and causeless fear, symptoms of depression;
• signs of complications from the sensory organs are extremely rare, however, taste disturbance and blurred vision are possible;
• violations of cardiovascular activity can occur in the form of shortness of breath, tachycardia, increased blood pressure, which is reflected in the electrocardiogram, the onset of a heart attack and attacks of hypertension is theoretically possible;
• from the side of various parts of the respiratory tract, coughing is sometimes possible, nosebleeds are noted in isolated patients, and bronchospasm is extremely rare;
• due to metabolic disorders, edema occurs, in some cases appetite worsens, or vice versa, weight gain occurs;
• skin manifestations of a hypersensitivity reaction (rash, itching, urticaria);
• complications of tissue functioning musculoskeletal system can make themselves felt in the form of minor cramps and pain in the muscles.

Also, taking Arcoxia is sometimes accompanied by a general deterioration in well-being (doctors call this condition a flu-like syndrome), an increased risk of developing infections of the urinary and respiratory systems. In addition, Arcoxia tablets can affect the results of a clinical blood test and liver tests, which should be taken into account when deciphering these studies.

Arcoxia: instructions for use and the possibility of combination with other medicines

Due to the peculiarities of the pharmacodynamics of the drug, to achieve a therapeutic effect, the drug can be taken only once a day.

The maximum dosage is 120 mg. This amount of Arcoxia instructions for use recommends drinking with severe pain arising from psoriatic arthritis.

With osteochondrosis, it is necessary to take 0.6 g per day, for the treatment of rheumatoid arthritis and spondylitis, 0.9 g is prescribed once a day.

As a rule, they drink the medicine regardless of the meal. The duration of therapy at the maximum allowable amount(1.2 g) - no more than 8 days, in other cases, the duration of admission is determined by the doctor. But since all NSAIDs are intended for the symptomatic relief of acute pain syndrome, the use of Arcoxia is stopped after the disappearance of the main clinical manifestations of the disease.

To simulate the symptoms of an overdose, the drug was given in a single dose of 500 mg. Another clinical study was conducted with the appointment of Arcoxia, the instructions for use of which clearly describe the method of taking the drug, in an amount of 150 mg per day for 3 weeks. During the tests, symptoms of overdose were not noted.

But doctors warn that exceeding the recommended number of tablets is fraught with unwanted reactions from the digestive and cardiovascular systems. Since there are no specific antidotes, and the removal of the drug by hemodialysis is ineffective, symptomatic therapy is carried out.

When combined with other Arcoxia drugs, the instructions for use advise taking into account the following points:

• Anticoagulants. There is a slight increase in the action of these drugs, so this combination requires correction of the dosage of anticoagulants and monitoring of blood coagulation parameters.
• Diuretics. When combined with Arcoxia, complications from the excretory system may occur.
• Angiotensin-converting enzyme inhibitors. This NSAID weakens their hypotensive effect.
• Aspirin and other drugs containing acetylsalicylic acid. Such a combination is justified for the prevention of the occurrence of pathologies of the cardiovascular system during the treatment of Arcoxia. At the same time, the combination of drugs increases the risk of erosive lesions of the mucous membrane of the digestive tract.
• Immunosuppressants (Cyclosporin and Tacrolimus). Simultaneous reception with Arcoxia has a nephrotoxic effect.
• lithium preparations. This NSAID can increase its concentration in the blood.
• Methotrexate. The question of the combination of this drug with Arcoxia is very relevant in rheumatology, since this cytostatic agent is the first-line drug for long-term therapy of rheumatoid arthritis. After clinical trials doctors came to the conclusion that when using medications in the recommended dosages, the risk of complications is minimal, however, it is possible to increase the side effects of Methotrexate.
• Oral contraceptives. The risk of developing thromboembolism increases.
• Corticosteroids. There were no complications associated with the combination with Arcoxia.
• Rifampicin. Reduces the rate of NSAID metabolism in the liver.
• Antacids. Do not affect the bioavailability and pharmacodynamics of the main drug.

When taking Arcoxia, the instructions for use describe in detail all the combination options with other drugs. However, if you have additional questions, it is better to consult with a specialist.

Arcoxia medicine: special instructions for use

The drug is sold in every pharmacy, you can buy it without a doctor's prescription. Store at room temperature away from children. Shelf life - 3 years from the date of production. At long-term use(more than 8 days) Arcoxia requires monitoring of blood pressure numbers and clinical indicators of liver function. If serious changes are detected, the drug should be discontinued. Also, the drug is not combined with other NSAIDs.

The drug Arcoxia slightly affects the ability of the egg to fertilize, which must be taken into account by women planning a pregnancy. The drug may cause drowsiness and dizziness. This needs to be taken into account by drivers and other patients whose work is related to the speed of reaction. The shell of the tablets contains a small amount of lactose, which can adversely affect the health of patients with lactase deficiency.

Arcoxia drug: analogues, use during pregnancy, lactation and at an early age, cost

There are no analogues of the drug with the same composition on the pharmaceutical market today. To some extent, other selective cyclooxygenase type 2 inhibitors can replace Arcoxia. However, their choice is very limited.

Relative analogues of this tool are:

• Nimesulide (Nimulid, Nise, Nimesil), appoint 0.1-0.2 g twice a day.
• Meloxicam (Amelotex, M-Kam, Movalis), take 7.5-15 mg once a day.

According to doctors and patients, this new NSAID is very effective. It quickly relieves pain and other symptoms of the inflammatory process. According to clinical trial data, Arcoxia is much less likely to cause side effects, regardless of the duration of treatment. It also features ease of use. The cost of a package of 28 tablets is: 30 mg - 692.00, 60 mg - 1016 rubles, 90 mg - 1362 rubles.

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