Diphenhydramine instructions for use in dose ampoules. Release form and packaging. Pharmacological action according to the instructions

1. Pharmacological action

Drug group:

Antihistamine.

Therapeutic effects of Dimedrol:

• Antihistamine;
• Antiemetic;
• Antiallergic;
• Hypnotic;
• Sedative;
• Local anesthetic.

Peculiarities:

• Able to pass through the placental and blood-brain barriers;
• Widely distributed throughout the body and excreted in breast milk;
• The maximum effect of the drug develops after 1 hour and lasts for 4-6 hours.

2. indications for use

The drug is used for:

• Complex treatment radiation sickness, gastric ulcer, bronchial asthma, hyperacid ;
• Treatment, vasomotor, acute iridocyclitis, angioedema, serum sickness, hay fever, pruritic dermatoses, allergic, capillary toxicosis, various allergic complications, sleep disturbances, extensive injuries of the skin and soft tissues, chorea, vomiting, colds, parkinsonism, airway and/or seasickness, Meniere's syndrome;
• Premedication, local anesthesia in patients with hypersensitivity to local anesthetics.

3. How to use

Recommended dosage of Diphenhydramine in tablet form:

Insomnia:

50 mg half an hour before going to bed;

Postencephalic or idiopathic parkinsonism:

25 mg 3 times a day with a gradual increase in dosage to 50 mg 4 times a day;

Motion sickness:

25-50 mg every 4-6 hours if necessary;

Children 2-6 years old:

12.5-25 mg;

Children 6-12 years old:

25-50 mg every 6-8 hours;

Children over 12 and adults:

30-50 mg 1-3 times a day.

Recommended dosage of the drug in parenteral form:

Intramuscularly:

50-250 mg;

Intravenous drip:

25-50 mg, dissolved in 75-100 ml of saline.

Children under 3 years old:

Children 3-4 years old:

Children 5-7 years old:

1-2 drops of 0.2-0.5% solution in the conjunctival sac 2-5 times a day;

Intranasally:

1 stick in each nostril;

Preparation in the form of a gel:

apply thin layer on the affected areas of the skin several times a day.

Application Features:

• According to the instructions, exceeding the dosage of the drug is not permissible, in order to avoid the occurrence of undesirable effects.

4. Side effects

Nervous system:

fatigue, decreased attention, drowsiness, drowsiness, impaired coordination of movements, irritability, nervousness, euphoria, convulsions, paresthesia, provocation of an epileptic seizure, general weakness, sedative effect, dizziness, headaches, anxiety, irritability, insomnia, confusion, neuritis;

Respiratory system:

nasal congestion, tightness chest, dry nose and throat, thickening of bronchial secretions, shortness of breath;

The cardiovascular system:

Digestive system:

short-term mucosal numbness oral cavity, nausea, vomiting, or constipation, dry mouth, anorexia, epigastric distress;

Urinary system:

urinary retention, frequent and / or difficult urination;

Reproductive system:

early menstruation;

Blood system:

decrease in the number of granulocytes and platelets,;

Sense organs:

diplopia, tinnitus, visual impairment, acute labyrinthitis;

Skin lesions:

photosensitivity;

chills, sweating.

5. Contraindications

6. During pregnancy and lactation

Pregnant women and nursing mothers should use the drug categorically contraindicated.

7. Interaction with other drugs

Simultaneous use of Dimedrol with:

Tranquilizers, sleeping pills, sedatives or alcohol-containing drugs:

improving their efficiency.

8. Overdose

Symptoms:

Nervous system:

depression or excitation (more often in children) of the central nervous system, convulsions, confusion, death;

Respiratory system:

labored breathing;

The cardiovascular system:

redness of the face;

Digestive system:

dry mouth.

Treatment of overdose with Diphenhydramine:

• Gastric lavage in the first few hours;
• Reception of activated carbon or other sorbent drugs in the maximum possible dosage;
• Maintaining vital important indicators within the normal range;
• symptomatic treatment.

9. Release form

• Coated tablets, 50 mg - 10, 20, 30, 1500, 1600 or 4000 pcs.
• Solution for injection, 10 mg / 1 ml - amp. 10 pieces.

10. Storage conditions

• Being in the original packaging or tightly closed container;
• Dry dark place out of reach of children, sunlight and heat sources.

Various, depends on dosage form and the manufacturer is indicated on the packaging.

11. Composition

1 tablet:

• diphenhydramine - 50 mg.

1 ml solution:

• diphenhydramine - 10 mg.

12. Terms of dispensing from pharmacies

How to breed Diphenhydramine with Analgin

When intense heat and pain effectively helps the combination of Dimedrol with Analgin. Instructions for use Dimedrol says that the drug is an anti-allergic agent that eliminates allergies, relieves swelling. Analgin is a non-steroidal anti-inflammatory drug that relieves pain, fever and inflammation. In combination, these agents are most effective, so they are often used in one syringe.

This combination has an effect after 15 minutes and lasts for about 6 hours. It is better for children to use Diphenhydramine with Analgin in the form of candles, which are called Analdim, but, in last resort, apply and injection.

For children, the dosage of Analgin with Diphenhydramine is calculated depending on weight and age. For adults weighing about 60 kg, 2 ml of Analgin and 1 ml of Dimedrol are used.

These are only approximate dosages, the exact amount of the drug is determined only by the doctor.!

The drugs are collected in 1 syringe. First Analgin, then Dimedrol. In this case, the drugs do not mix. This mixture should be administered slowly and intramuscularly.

Is it possible Diphenhydramine with alcohol

Combining Diphenhydramine with alcoholic beverages is dangerous not only for health, but also for life. The drug enhances the effect of alcohol, which can even lead to death.

In addition to severe intoxication, the liver, kidneys, and organs begin to suffer. gastrointestinal tract, heart and nervous system. Alcohol in combination with Diphenhydramine can lead to hallucinations and change a person beyond recognition.

It is not known exactly what consequences such a combination will lead to, therefore it is strictly forbidden to take Diphenhydramine with alcohol.

Analgin, Diphenhydramine and Papaverine in one syringe

The combination of drugs such as DimedroI, Analgin and Papaverine is very often used in one syringe. This combination is used in surgery, gynecology, urology, therapy and other fields..

The lytic mixture is used to relieve fever, pain and spasm. Analgin provides analgesic and antipyretic effect. Papaverine relieves muscle spasms and dilates blood vessels. Diphenhydramine is able to eliminate allergic manifestations, and also has a sedative effect.

To obtain a lytic mixture, 2 ml of 50% Analgin, 1 ml of 1% Diphenhydramine and 2 ml of 2% Papaverine are collected in one syringe for adults. This combination is administered intramuscularly and slowly.

For children, the dosage of the mixture is calculated depending on weight and age.

But it should be remembered that it is dangerous to use such a combination on your own, because the drugs have a number of side effects and contraindications.

Diphenhydramine for insomnia

Diphenhydramine is antihistamine, but due to its sedative effect, it is often used for insomnia. At the same time, the instructions noted that a sedative and hypnotic effect occurs when the drug is taken again.

The doctor prescribes the exact dosage and duration of treatment, on average, for insomnia, 50 mg of the drug will be used half an hour before bedtime.

Diphenhydramine has a number of side effects and contraindications, and in case of an overdose it leads to undesirable consequences Therefore, it is strictly forbidden to prescribe the drug as a sleeping pill on your own. Especially since medicine dispensed by prescription.

Diphenhydramine for toothache and headache

In the instructions for Dimedrol, among the therapeutic effects, you can see that the drug causes local anesthesia. Namely, when taken orally, a short-term numbness of the oral mucosa occurs. But can Diphenhydramine be used for toothache, as well as headaches?

Diphenhydramine is usually used for toothache, in the absence of other painkillers before visiting the dentist. To do this, a quarter or half of the tablet is placed on the aching tooth and wait for the onset therapeutic effect. And also the drug can be ground into powder and applied to the gum of the disturbing tooth.

It should be borne in mind that the drug causes drowsiness and reduces concentration, so it is preferable to use it before bedtime, and go to the dentist in the morning.

With intense headache and toothache, Analgin and Diphenhydramine combinations are used once, 1 tablet each or in the form intramuscular injections in one syringe.

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*Instruction for medical use to the drug Diphenhydramine is published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

Tradename: Diphenhydramine

International non-proprietary name:

Chemical Name: N,N- Dimethyl-2-(diphenylmethoxy)ethylamine hydrochloride

Dosage form:

Compound.
Active substance: dimedrol (diphenhydramine) - 0.05 g.
Excipients: milk sugar (lactose), talc, potato starch, calcium stearate.

Description: tablets white color flat-cylindrical with a chamfer.

Pharmacotherapeutic group:

ATX code

pharmachologic effect
Blocker of H1-histamine receptors of the first generation. It blocks H1-histamine receptors and eliminates the effects of histamine mediated through this type of receptor. action on the central nervous system due to blockade of H 3 -histamine receptors in the brain and inhibition of central cholinergic structures. It has a pronounced antihistamine activity, reduces or prevents spasms caused by histamine smooth muscle, increased capillary permeability, tissue edema, itching and hyperemia. calls local anesthesia(when taken orally, there is a short-term numbness of the mucous membranes of the oral cavity), blocks the cholinergic receptors of the ganglia (reduces blood pressure) and the central nervous system, has a sedative, hypnotic, antiparkinsonian and antiemetic effects. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergy than to systemic ones, i.e. decrease blood pressure. In people with local brain damage and epilepsy, it activates (even at low doses) epileptic discharges on the electroencephalogram and can provoke epileptic seizure. Sedative and hypnotic effects are more pronounced with repeated doses.
The onset of action is noted 15-60 minutes after ingestion, the duration is 12 hours.

Pharmacokinetics.
Rapidly absorbed in the gastrointestinal tract. Bioavailability - 50%. TSmax - 2040 min (the highest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Communication with plasma proteins - 98-99%. Penetrates through the blood-brain barrier. It is metabolized mainly in the liver, partially in the lungs and kidneys. It is excreted from the tissues after 6 hours. The half-life is 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and may cause sedation in children infancy(a paradoxical reaction characterized by excessive excitability may be observed).

Indications for use
allergic conjunctivitis, allergic rhinitis, chronic urticaria, pruritic dermatoses, dermatographism, serum sickness, in complex therapy anaphylactic reactions, angioedema and others allergic conditions.
Insomnia, chorea, Meniere's syndrome, sea and air sickness, as an antiemetic.

Contraindications
Hypersensitivity, angle-closure glaucoma, hyperplasia prostate, stenosing peptic ulcer stomach and duodenum, cervical stenosis Bladder, bronchial asthma, epilepsy.
Childhood up to 7 years (for this dosage form).

Carefully- pregnancy, lactation.

Dosage and administration
inside. Adults and children over 14 years old: 25-50 mg (1/2-1 tablet) 1-3 times a day. Higher single dose- 100 mg, daily - 250 mg. With insomnia - 50 mg 20-30 minutes before bedtime. When motion sickness - 25-50 mg every 4-6 hours if necessary.
Children from 7 to 14 years old 12.5 - 25 mg (1 / 4-1 / 2 tablets) 1-3 times a day.

Side effect
Drowsiness, dry mouth, numbness of the oral mucosa, dizziness, tremor, nausea, headache, general weakness, decreased psychomotor reaction rate, photosensitivity, accommodation paresis, impaired coordination of movements. Children may have a paradoxical development of insomnia, irritability and euphoria.

Overdose
Symptoms: depression of the central nervous system, development of agitation (especially in children) or depression, dilated pupils, dry mouth, paresis of the gastrointestinal tract, etc.
Treatment: there is no specific antidote. Gastric lavage. If necessary - symptomatic treatment: drugs that increase blood pressure, oxygen, intravenous administration plasma-substituting liquids.
Do not use epinephrine and analeptics.

Interaction with other drugs
Enhances the effect of ethanol and drugs that depress the central nervous system.
Monoamine oxidase inhibitors enhance the anticholinergic activity of diphenhydramine.
Antagonistic interaction is noted when co-administered with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning.
Enhances the anticholinergic effects of drugs with anticholinergic activity.

special instructions
Patients with potentially dangerous species activities requiring heightened attention and rapid mental reactions, care should be taken. During treatment with diphenhydramine, sun exposure and the use of ethanol should be avoided.
It is necessary to inform the doctor about the use of this drug: antiemetic action may make it difficult to diagnose appendicitis and recognize symptoms of an overdose of other drugs.
In children from 1 year to 7 years, it is recommended to use 30 mg tablets (from 1 year to 3 years daily dose 10-30 mg, divided into 2-3 doses, from 4 to 6 years, a daily dose of 20-45 mg, divided into 2-3 doses).
In children from 7 months to 12 months, the drug can be used in the form of a powder prepared in the prescription and production departments of pharmacies, 3-5 mg 2-3 times a day.

Release form
Tablets 50 mg.
10 tablets in a blister pack or in a blister pack. 2, 3 or 5 blister packs together with instructions for use are placed in a pack of cardboard.

Best before date
5 years. Do not use the drug after the expiration date.

Storage conditions
List B. In a dry, dark place and out of the reach of children.

Holiday conditions
On prescription.

Manufacturer / organization accepting claims:
OJSC "Dalkhifarm",
680001, Khabarovsk, st. Tashkentskaya, 22.

A drug such as Diphenhydramine has been used in therapy for several decades in a row. international title this remedy is diphenhydramine. There are several forms of release of Dimedrol, ampoules are one of them. Today we will tell you in detail about the scope of use of this drug according to its instructions.

Product characteristics

The most common area of ​​​​use of Dimedrol is the treatment allergic diseases. This drug helps to block the synthesis of histamines, which prevents the subsequent development of allergies.

Diphenhydramine is a first generation remedy used to treat allergies, respectively, it has a lot of side effects despite this continues be widely popular. First of all, due to its affordable price.

Diphenhydramine was included in the WHO list of essential medicines. It is not only used for the treatment allergic manifestations but also to reduce body temperature and pain relief. In such cases, Dimedrol in ampoules is mixed with solutions of analgin and papaverine and an injection is given to the patient.

The action of Dimedrol in ampoules

This drug in the form of ampoules, according to the instructions, is an antihistamine synthetic agent that has a pronounced anti-allergic effect.

Diphenhydramine injections have a sleeping pill and sedative effect similar to a neuroleptic.

And also Diphenhydramine has such effects:

1. Antispasmodic.
2. Central cholinolytic.
3. Antiemetic.
4. Anti-inflammatory.
5. Ganglioblocking.

Dimedrol injections relax spasms smooth muscles, reduce the permeability of thin vessels, relieve swelling of tissues, prevent the development anaphylactic shock and other conditions provoked by allergies.

The components of Dimedrol in ampoules used for injections are as follows: the main component is diphenhydramine hydrochloride; auxiliary - water for injections.

Indications for the use of the drug

The specialist prescribes Dimedrol to the patient in such cases as:

Pharmacological action according to the instructions

The peculiarity of the effect of Diphenhydramine in the form of ampoules is to block a number of receptors that are responsible for the synthesis of components that provoke allergies. And also the drug helps to relax smooth muscles and soothe, relieve pain syndrome and have an antiemetic effect.

The doctor prescribes the release form depending on the diagnosis of the patient. Diphenhydramine is sold in the form ampoules, tablets or powder.

Tablets are most often prescribed in the treatment of allergic diseases, and for the treatment of rhinitis, the use of special sticks with medicine inside is more often prescribed, they help get rid of itching and swelling and also reduce capillary permeability.

The drug enters through the blood-brain barrier, then is metabolized in the liver, or in the lungs or kidneys. During the day, the drug is excreted through the kidneys in the form of metabolites conjugated with glucuronic acid.

It is worth knowing that when using this remedy during lactation a large number of drug, comes out with milk which may have a sedative effect on the child. In other cases, the reaction may manifest itself in the form of increased excitability.

According to the instructions for the drug in the form of ampoules, there are such contraindications:

Dosage and side effects

According to the instructions, Dimedrol in ampoules is prescribed in the form of injections for adults and children from 12 years of age. The amount of the drug is from 10 to 50 mg at a time.

If a patient has had at least one side effect while using this drug, should stop using it or visit a doctor.

If you give injections with Dimedrol, then they can disrupt function various organs and systems. The instruction to the drug states that the following disorders can be observed from the side of the central nervous system:

• dizziness;
• headache;
• weakness general;
• inhibition of actions and reactions;
• increased drowsiness;
• problems with consciousness;
• paresthesia;
• euphoria or strong arousal;
• insomnia;
• neuritis;
• convulsions;
• lack of coordination;
• restless syndrome.

The human digestive organs may respond to the medication in the following way: appears severe nausea and vomiting reflex; constipation or diarrhea; pain in the stomach area; dry mucous membranes; anorexia.

In some cases, there are problems with blood vessels and the heart, pressure decreases, tachycardia or extrasystole is observed.

Damage to the sense organs is expressed by such symptoms: decreased visual acuity; observed diplopia and acute labyrinthitis; hearing deteriorates.

Sometimes the use of the drug provokes such allergic phenomena as: anaphylactic shock; urticaria; photosensitivity.

The instruction says that if the functions of the organs that take part in hematopoiesis are violated, then hemolytic anemia, agranulocytosis or thrombocytopenia. And when it hits genitourinary system, then urination is delayed, in women it is disturbed menstrual cycle chills and profuse sweating.

Taking with other drugs

There are some peculiarities of taking this remedy along with other drugs. According to the instructions, diphenhydramine should not be taken together with such medicines:

If the doctor has prescribed you Dimedrol in injections or tablets, then you need to follow some precautions:

An overdose of this drug is manifested in the form of difficulty breathing, severe dryness in the mouth, redness of the eyes, persistent mydriasis. In children, strong excitement can be observed, in adults, the state is often depressed. The central nervous system may be affected, consciousness is confused, convulsions develop.

• the patient's stomach is washed;
• induction of vomiting;
• reception activated carbon;
• assign support and symptomatic therapy against the background of careful monitoring of the patient's breathing and blood pressure.

As stated earlier, Diphenhydramine has different forms . The powder is sold in dosages of 0.02, 0.03 and 0.05 grams. Candles with Diphenhydramine have a dosage of 0.001 to 0.02 grams, and sticks with the drug - only 0.05 grams. For injections, Diphenhydramine is offered as a 1% solution in ampoules or syringe tubes. Another drug can be purchased in the form of special pencils or gels for external use.

We learned what effect this remedy has according to the instructions, what are the features of its administration in ampoules and what side effects he can call. If your doctor prescribed this drug, read the instructions carefully and take it all into account.

Diphenhydramine is an antiallergic pharmacological agent, working on the principle of blocking the work of histamine H1 receptors. This drug has been widely used in medicine over the past few decades.

Diphenhydramine is produced in the form of a solution for injection intravenously and intramuscularly, placed in ampoules, as well as in the form of tablets for oral intake. As the main active component diphenhydramine acts in this drug. One milliliter of the drug contains 10 milligrams of this substance (1 percent). Diphenhydramine is available in 1 ml ampoules.

Operating principle

The action of Dimedrol is based on its ability to block H1-histamine receptors and m-cholinergic receptors in the brain. As a result, there is a decrease in the likelihood of spasms of smooth muscles that occur against the background of the action of histamines, tissue edema is excluded, the overall permeability of capillaries increases, and itching and swelling are eliminated. Also, the drug is able to work as an anesthetic and a sedative with a pronounced hypnotic effect.

In addition, the agent has a certain effect on the vessels in the event of allergic and inflammatory reactions which helps lower blood pressure. However, the use of this agent by patients with low blood volume in circulatory system, there is a possibility of increased symptomatic manifestations of arterial hypotension.

In patients who have partial damage brain and epileptic seizures, even when using low doses of the drug, epileptic discharges are noted, which can cause seizures of an epileptic nature.

Diphenhydramine differs in bioavailability at the level of 50 percent. highest concentration drug in the body depending on individual features the patient is reached 20-50 minutes after the injection. highest concentration active substance determined in the tissues of the lungs, kidneys, liver and spleen. The drug has a relationship with plasma proteins at the level of 98-99 percent. Diphenhydramine is able to penetrate the blood-brain barrier.

The drug is mainly metabolized in the liver cells, and also partially in the kidneys and lungs of a person. Tissue elimination period internal organs is 6 hours. The duration of the half-life is from 4 to 10 hours.

A day later, the drug is completely excreted through the kidneys in the form of metabolites, which are conjugated with glucuronic acid. A fairly significant part of the active substance of the drug is excreted through breast milk, from which it can have a pronounced sedative effect on the child or, conversely, a backlash in the form of excessive overexcitation.

What helps and what are the contraindications

The main indications for the use of Dimedrol include:

• itching allergic origin;
• that arose against the background of an allergic reaction;
• allergic type;
• chronic form;
• itchy ;
• dermatographism;
• and other allergic reactions of the body.

Diphenhydramine can also be used as a sleeping pill. sedative in case of sleep disturbance.

Contraindications for the use of liquid Diphenhydramine include following states patient:

• individual sensitivity to individual components that make up the drug;
• angle-closure glaucoma;
• state of prostate hyperplasia;
• stomach ulcer;
• bladder stenosis;
• chronic epileptic seizures;
• increased blood pressure.

Instructions for use Dimedrol in ampoules for adults and children

Diphenhydramine in liquid form is intended for intramuscular and intravenous injections. For children over 12 years of age and adults, this drug is prescribed at a dosage of 10 to 50 mg per day. The maximum daily dose cannot exceed 150 mg. For children under the age of one year, this drug is prescribed in the form of injections with doses of 0.2 to 0.5 milliliters per day. Children aged 2 to 5 years - 0.5-1.5 milliliters per day, from 6 to 12 years - 1.5-3 milliliters per day. The interval between injections should be at least 6-8 hours.

Pregnant women should not use this medicine unless the benefits outweigh the possible Negative consequences for developing fetus. At breastfeeding during the use of Dimedrol, it is recommended to stop breastfeeding.

In some cases, Dimedrol in ampoules can be drunk. It should be noted that in order to achieve an effect similar to the tablet form of Diphenhydramine, it is necessary to increase total dosage his liquid form when using a solution for injection inside.

Diphenhydramine acts as a sleeping pill for 30 minutes, but this time may vary depending on the individual characteristics of the patient's body.

Overdose and possible adverse reactions

In case of an overdose of Diphenhydramine, excitation or, conversely, depression of the nervous system may occur. This effect especially pronounced in children. In addition, dryness in the mouth, dilated pupils and problems with the functioning of the digestive system may occur.

In case of exceeding the amount of the injected drug, it is necessary to eliminate symptomatic manifestations. In the process of eliminating the consequences of an overdose of Diphenhydramine, the use of analeptics and adrenaline is strictly prohibited.

The nervous system when using Diphenhydramine may show the following adverse reactions: fatigue and drowsiness, uncoordinated movements, sleep disturbance, a decrease in the speed of mental and motor reactions, constant irritability, limb tremor.

The heart and blood vessels often react as follows: heart rate, a drop in blood pressure, the development of extrasystole.

There is also the possibility of developing allergic reactions like: itching and rash on the skin, condition, the appearance of urticaria.

On the part of the organs involved in hematopoiesis, the following side effects may occur: thrombocytopenia, anemia, and the development of agranulocytosis.

In addition, the use of Diphenhydramine in some patients may cause problems with urination.

Important Information

Diphenhydramine is able to enhance the effect of alcohol and any other drugs that differ in their effect on the central nervous system. For this reason, alcoholic beverages should be avoided while using this drug.

Due to the simultaneous use of Analgin and Dimedrol, the effect of this remedy can be enhanced.

In the presence of chronic diseases kidneys and liver, it is important to consult a doctor before taking the medicine to minimize side effects.

Everyone knows that with insomnia and anxiety, Diphenhydramine is used for sleep. In addition, this drug has antihistamine, analgesic and antispasmodic effects. For the drug to have desired effect on the human body, you need to know its indications, as well as possible side effects.

Description of the drug

Diphenhydramine is produced in the form of tablets in blisters of 20, 30 or 50 mg, ampoules for intramuscular or intravenous injections. In addition, the following dosage forms are on sale:

• soluble powder;
• liquid capsules;
• candles;
• stripes;
• gels.

The active ingredient is diphenhydramine.

What are the indications for use

The drug in various forms release is prescribed for the treatment of such pathologies:

• insomnia;
• allergic conjunctivitis, rhinitis;
• the reaction of the body to the flowering of plants;
• serum sickness;
• acute iridocyclitis;
• hives;
• itchy dermatoses;
• hay fever;
• complications allergic nature in the treatment of radiation sickness, blood transfusions and replacement fluids;
• angioedema;
• treatment of abnormal movements, including Parkinson's disease, Meniere's syndrome;
• in the complex therapy of gastric ulcer, anaphylactic shock, bronchial asthma, gastritis;
• injuries of the skin, soft tissues;
• motion sickness and vomiting in transport, with air and sea sickness.

The dosage and treatment regimen is prescribed by the doctor after the examination and examination of the patient.

Contraindications and special instructions

Along with a large area of ​​​​use, Diphenhydramine has a number of contraindications that should not be neglected.

It is forbidden to take this drug to persons who have shown hypersensitivity to the components of the drug while driving vehicle, as well as in the presence of the following diseases:

• prostatic hypertrophy;
• closed glaucoma;
• epilepsy;
• stenosis of the stomach ulcer, neck of the bladder;
• children (prematurity and neonatal period).

It is necessary to carry out therapy with Diphenhydramine drugs with caution in cases of pulmonary pathologies, increased intraocular pressure, in old age, with diseases of the heart and blood vessels, pulmonary pathologies, during pregnancy and lactation. The substance is not recommended for use by people who, by the nature of their activities, require concentration of attention or control of transport.

People who suffer from phenylketonuria need to know that instant capsules and chewable tablets, which include Diphenhydramine, often contain aspartame - a source of phenylalanine.

Side effect

Uncontrolled use medicinal product, its overdose or combination with other pharmaceutical products can provoke the development of adverse reactions.

The most commonly observed disorders are:

• on the part of the digestive system: dry mouth, nausea, vomiting, impaired stool, loss of appetite, mucosal numbness;
• nervous system: drowsiness, neuritis, convulsions, fatigue, euphoria, impaired coordination of movements, weakness, headache;
• violation of the respiratory system: congestion or dryness of the nasal passages, difficulty breathing, thickening of bronchial secretions;
• changes in the activity of the heart and the state of the vessels, namely: palpitations, thrombocytopenia, hypotension, anemia, tachycardia;
• allergic reactions.

In addition, the patient may have excessive sweating or chills, photosensitivity.

In case of an overdose, a pronounced depression or overexcitation, depression, dilated pupils, redness of the face.

If an injection is necessary, doctors do not recommend the method of administering an injection under the skin.

Attention! AT severe cases children may develop confusion, convulsions up to death.

After taken drug to remove side effects, it is necessary to do a gastric lavage, to control blood pressure.

Benefits of using

Reviews of people who have taken Diphenhydramine in various forms indicate that it can be very effective in the development infectious diseases, removing swelling and redness in the mucous membranes and helping the patient to fall asleep.

Diphenhydramine in combination with other drugs well brings down the high temperature, enhances the effect of the latter. Such lytic mixture has analgesic and hypnotic effects. When allergic reactions to skin it is better to use ointments, aerosols or lotions that contain diphenhydramine. These drugs have a local effect on trouble spot relieve itching and discomfort. Besides, topical application avoids systemic effects such as drowsiness and does not affect the gastric mucosa. For insect bites, you can use the solution from the ampoule, which needs to be moistened cotton swab and apply to the affected area.

Other pluses:

• cheapness;
• fast action;
• pressure reduction;
• calming effect;
• preservation of the effect during the day.

Negative points

Despite a number positive qualities, the tool has drawbacks that make you think about the appropriateness of its use.

Minuses:

• prescription only;
• new generation analogues are more accessible and cause fewer adverse reactions;
• in the form of injections is more effective than in tablets;
• addictive;
• toxic, may cause hallucinations;
• must be taken strictly according to the instructions;
• lethargy, inability to control emotions;
• causes headache and bad feeling next morning.

Is it possible to give to children

It is not recommended to take pills for the treatment of colds and coughs. The child may choke. In case of removal of allergic manifestations, it is better to use rectal suppositories by making an enema beforehand. With insomnia or sleep disturbance, children are given softer sedatives that do not cause complications. Intramuscularly, Diphenhydramine is administered to children only in mixtures with other pharmaceutical products in order to reduce high temperature under the supervision of a physician.

During pregnancy and lactation

Apply this drug during pregnancy is possible only on the appointment of a specialist. If the pathology may have severe consequences and negatively affect the fetus, a woman may be allowed to take this substance, taking into account the duration of pregnancy. In this case, the treatment of symptoms of urticaria, conjunctivitis or pruritic dermatosis is carried out by a single or double dose of tablets.

Important! In the first and second trimester Diphenhydramine is contraindicated.

During lactation, the drug is not prescribed due to the development of the risk of complications for the child.

How it affects the elderly

People over 65 years of age should not take the drug due to the fact that they can haveanticholinergic effect, which has such manifestations:

• disturbance of accommodation;
• increased heart rate;
• dizziness;
• urinary retention
• constipation, intestinal obstruction;
• memory loss.

Interaction with alcohol

Preparations containing dimerdol enhance the effect of alcohol and cause irreparable harm to the body. First of all, the liver and kidneys suffer. Taking a small dose of alcohol with a tablet of the drug, an alcoholic falls into drug intoxication. Outwardly, this is manifested in increased gesticulation, excitement and aggression. Then comes deep sleep dreamless. Often there are terrible hallucinations, they are accompanied by hand tremors, blurred vision, tachycardia. Repeated combination of Dimedrol with alcoholic drinks leads to apathy, dependence, destruction of personality and death.