Ibuprofen suspension dosage. Ibuprofen - antipyretic syrup: composition, dosage, instructions for use for children and adults. Ibuprofen review. Reviews of ibuprofen. Nurofen analogue. What is ibuprofen for?

Ibuprofen is an effective and safe antipyretic drug that has anti-inflammatory and analgesic properties and is intended for use in children. different ages. At a temperature in children, Ibuprofen is the first antipyretic. The drug is produced in the form of syrup, rectal suppositories, tablets and suspensions. Such a wide choice of release forms has its own field of influence, which is important to know about for use at home. The drug is recommended to be used after the permission of the doctor, so you should first consult with your local doctor.

Main indications for use

Instructions for use of the drug Ibuprofen states that it should be used in case of complex therapy. The main indications for use include the following diseases:

infectious diseases accompanied by fever;
toothache;
SARS and various forms of influenza;
headache;
pain symptoms in the joints and muscles;
musculoskeletal injuries.

Instructions for use provides for a short course of treatment of the above diseases. If it is necessary to use the drug on a long-term basis, it is required to monitor the state of the functioning of the liver, kidneys and peripheral blood. Ibuprofen for fever for children is used in various forms release, which depends not only on the age of the patient, but also on the form and type of the disease. Let us consider in more detail each form of release and find out in which cases the funds are indicated for use.

Candles Ibuprofen: in what cases it is required to apply

Ibuprofen for children in the form of rectal suppositories is intended for use from the age of three months. The pediatrician prescribes Ibuprofen suppositories to the child in the presence of the following indications:

an increase in body temperature over 38-38.5 degrees;
pain in the throat area;
SARS;
inflammation of the inner ear.

If the baby has symptoms of fever along with vomiting or nausea, then it is forbidden to resort to the use of other forms of Ibuprofen release, except for suppositories. This is due to the fact that during vomiting the entire composition of the drug will be removed from the body. The effectiveness of candles is not inferior to other forms of release this tool. It is not recommended to use rectal suppositories if little patient symptoms of diarrhea and diarrhoea. The main contraindications for the use of ibuprofen suppositories include:

inflammatory processes in the intestines;
ulcerative types of diseases;
bronchial asthma;
bleeding in the gastrointestinal tract;
intolerance to the composition of the drug.

Ointment for the treatment of external inflammatory processes

The activity of Ibuprofen in the form of an ointment is due to its composition. Ointment is used in the presence of the following indications:

inflammatory processes in the tendons;
injury to non-skeletal tissues;
acute pain in the lumbar region.

It's important to know! Ibuprofen in the form of an ointment is allowed to be used in children over the age of 12 years.

The ointment should only be applied externally. For use, it is necessary to apply the ointment to the affected areas, then rub thoroughly until the cream is completely absorbed. skin. The interval between subsequent applications of the ointment should be at least 6 hours. The duration of treatment with ointment is no more than 20 days. Children are not allowed to use the product on their own and only as directed by a doctor.

The main types of contraindications to the use of ointment are:

allergic manifestations;
the presence of damage to the skin;
after the surgical period;
symptoms of dyspepsia.

Syrup, tablets and suspension

Syrup is the most popular form of Ibuprofen. Instructions for use of Ibuprofen in the form of tablets, syrup and suspension states that doctors prescribe the drug for the following ailments:

toothache;
violations of the periphery of the nerves;
arthritis, complicated by infectious signs;
migraine.

A special measuring syringe is included with the syrup. With this syringe it is convenient to calculate the dosage of the drug.

Dosage and application features

With an increase in temperature in children, it is recommended to give preference to just such a form of release as rectal suppositories. The disadvantage of this form of release, like candles, is the long-term effect on reaching positive results. Candles take longer to decompose than tablets or syrup. Consider the features of the use of Ibuprofen in all available forms of release.

Tablets

Ibuprofen tablets are recommended for children between main meals. A medication is prescribed in dosages of 5 to 10 mg per 1 kg of body weight. Tablets are prescribed for use throughout the day 3-4 times a day. The main dosage of taking tablets for children at different ages:

Age from 3 to 6 years - 300 mg / daily dose.
Age from 6 to 9 years - 400 mg.
Age from 9 to 12 years - 600 mg.
Age over 12 years - 800 mg.

Tablets are contraindicated for use in children under the age of three years. The above dosage is indicative, and a more accurate dose of application should be checked with your doctor.

Suspension

Ibuprofen suspension has quick effect, in relation to tablets. Before using the drug, shake the bottle thoroughly for 1 minute. Before use, be sure to read the instructions for use.

It's important to know! If the syrup is not shaken before use, the required amount of active substances of the agent will not enter the body.

The dosage of syrup and suspension is almost identical. Both forms of release should be used for children over the age of 6 months. The dosage will be as follows:

at the age of 6 to 12 months, the dosage is 50 mg;
from 1 year to 3 years - 100 mg / 3 times a day;
from 4 to 6 years - 150 mg / 3 times a day;
from 7 to 9 years - 200 mg / 3 times a day;
from 10 to 12 years - 300 mg / 3 times a day.

Re-administration of the medication is allowed no earlier than 6 hours later.

Candles

Rectal suppositories are intended directly for children over the age of 3 months. Instructions for use stipulate that suppositories after application begin their effect on the body after 20-30 minutes. Suppositories must be stored exclusively in the refrigerator. Insert the candle into anus the child should be careful. First you need to unpack it, then hold it in your hand for about 1 minute, then enter it into anus by pushing it with your finger 3-4 cm.

Can a child under the age of 3 months put an ibuprofen suppository? The instruction does not recommend administering the drug to children under 3 months of age. If there is a need for this, you should consult a doctor who will prescribe a dosage or other drug. From temperature for children from 3 to 9 months, 1 candle with a dosage of 60 mg should be placed. You can repeat the procedure no earlier than after 6-8 hours.

It's important to know! It is allowed to use Ibuprofen for children up to a year in an amount not more than 3 times a day.

Children aged 9 months to 2 years should put one candle in the amount of 4 times a day. The duration of the use of Ibuprofen to reduce fever is 3 days, and as an anesthetic - no more than 5 days. It is strictly forbidden to increase the dose of the medication on your own.

What happens with an overdose

During an overdose, there are the following symptoms:

vomiting and nausea;
pain in the abdomen;
migraine;
headache;
loss of appetite;
mental disorders;
renal and heart failure.

If there are signs of an overdose of antipyretic, then you need to go to the hospital. If the symptoms of an overdose disappear after a while, then you should not repeat the use of the drug. In case of an overdose in children, there may be a deterioration in sleep and insomnia, so it is important to control the dose of the drug. If the dosage of the drug has been violated, then you can give the child a drink charcoal tablets. Wait for development adverse reactions should not be, as they can appear after 2-3 hours.

The main types of contraindications

The instructions for use for any form of release of Ibuprofen describe the main types of contraindications. If they are present in a child, the use of the drug should be excluded and the doctor who prescribed the medicine should be informed about this. The main types of contraindications include diseases such as peptic ulcers, colitis, gastritis, bleeding disorders. In the presence of impaired functioning of the kidneys, liver, heart and blood vessels, the drug should be used with caution.

If a small patient has diseases optic nerve, as well as hypersensitivity to the components of the drug, then it should be completely excluded this drug in any form of release. Children under 6 years of age should not use Ibuprofen unless directed by a doctor. During pregnancy and breastfeeding it is necessary to consult a doctor before taking the drug in any form of release.

Drug Interactions

If Ibuprofen is used in conjunction with other types of medicines then you need to know the following:

When using Ibuprofen with other drugs of the NVPS group, a weakening of the effect of the antipyretic drug is observed.
When combined with anticoagulants and thrombolytics, the risk of internal bleeding increases.
Joint use with gold preparations increases medicinal properties, as well as a decrease in the rate of excretion of the drug from the body.

When taking ibuprofen, it is important to exercise caution and control the dosage. In pharmacies, the drug is sold without a prescription, so it is important to follow the dosage prescribed by the doctor. Continue therapeutic treatment more than 5 days without a doctor's appointment is strictly prohibited. At the slightest sign deterioration of the patient's well-being, it is required to exclude the use of the drug.

In conclusion, it should be noted that Ibuprofen is universal remedy, allowing to normalize the condition of small patients, reduce pain, reduce high temperature body, cure viral and infectious diseases. The drug is effective only if it is used correctly.

Ibuprofen for children comes in several forms. The article will describe the syrup in detail. The medicine has painkillers and anti-inflammatory effect, reduces body temperature.

Composition and forms of release

Issued in the form of syrup in a bottle of 100 ml. Included baby syrup Ibuprofen comes with a small measuring cup, a box and instructions for use.

The active ingredient of the drug is ibuprofen itself. His mass fraction in 5 ml of the drug is 100 mg.

The remaining substances are auxiliary. Among them:

polysorbate 80 s mass fraction 3 mg;
glycerol contains 500 mg;
sorbitol - 1050 mg;
sodium saccharinate - 1.5 mg;
citric acid - 7.5 mg;
xanthan gum - 30.0 mg;
sodium hydroxide solution - 1.071 g;
hydrochloric acid solution - 0.982 g;
methyl parahydroxybenzoate - 5.0 mg;
propyl parahydroxybenzoate - 1.5 mg;
the amount of flavoring does not exceed 1 mg;
the maximum amount of purified water is 5 ml.

The suspension itself is transparent or almost transparent. The density of the substance is high. There is a pronounced smell and taste of orange. The bottle is made of orange glass. The neck is made on a screw base. Cork - with the function of protection against children.

It belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs).

The action of the child's drug

The decrease in body temperature of the child occurs due to exposure to active substance to specific areas of the brain.

The influence is on those parts of it that are responsible for the thermoregulatory function. The analgesic effect is achieved due to the effect on pain receptors.

The working mechanism is aimed at relieve symptoms that cause fever, pain, and fever. The use of the drug improves blood microcirculation and eliminates vascular permeability . Inflammations are eliminated or become significantly less.

Complete elimination of the drug from the body takes approximately 22 hours.. Ibuprofen is mostly excreted in the urine. In the presence of serious problems with the liver and kidneys, you should consult a specialist about the possibility of using this drug.

Indications

It can be used for neuralgia, trauma, some ENT diseases. Completely relieves or reduces headache and toothache.

special instructions

The drug is dispensed without a prescription, so when self-prescribing, you should be guided by the rule that the dosage should be as low as possible, and the course of treatment should be short.

If necessary long-term treatment specialist advice required.

The doctor decides whether to prescribe the drug for serious illnesses liver and kidneys. He must be guided possible risk and potential benefit to the patient.

Dosage

Ibuprofen can take on an empty stomach or after meals. Shake well before use to obtain a homogeneous liquid. The dosage depends on the patient's age and weight.

At age 6-12 months and weighing up to 9 kg, you must take Ibuprofen 3-4 times 2.5 ml.
Children aged from one to three years and weighing up to 15 kg drink 5 ml 3 times a day.
Patients aged from 3 to 6 years and weighing no more than 20 kg should be given 7.5 ml 3 times a day.
children up to 9 years, whose weight does not exceed 30 kg, is required for treatment of 10 ml 3 times a day.
Aged 9 to 12 years old it is necessary to take Ibuprofen 3 times a day, 15 ml.

Contraindications

Diseases are contraindications gastrointestinal tract in the active stage.

Violation of blood clotting processes, kidney failure, severe forms kidney and liver diseases, hyperkalemia, inflammatory processes in the intestines, individual fructose intolerance are also contraindications for taking this medication.

It is necessary to consult with a specialist about the possibility of taking Ibuprofen for cirrhosis of the liver with portal hypertension, its insufficiency, ulcers, and colitis.

To minimize possible negative effects,instructions must be strictly followed on the use of ibuprofen syrup for children. Majority side effects caused not by individual intolerance, but by an overdose. Courses of treatment should be short, and the dosage should be as low as possible.

Combination with other medicines

Do not take it with diuretics, as this will significantly weaken the effect of the active substance of the drug. The effectiveness of removing the drug from the body also decreases.

Taking ibuprofen with anticoagulant and thrombolytic agents leads to bleeding.

Preparations of gold significantly enhance the therapeutic effect, but the rate of excretion of the drug from the body decreases.

In this article, you can read the instructions for using the drug ibuprofen. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of medical specialists on the use of Ibuprofen in their practice. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Ibuprofen analogues, if available structural analogues. Use for the treatment of inflammation and fever, as well as pain relief in adults, children, as well as during pregnancy and lactation.

ibuprofen- non-steroidal anti-inflammatory agent, a derivative of phenylpropionic acid. It has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins that play leading role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to both peripheral (indirectly, through the suppression of prostaglandin synthesis) and central mechanism(due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses platelet aggregation.

When applied externally, it has anti-inflammatory and analgesic action. Reduces morning stiffness promotes increased range of motion in the joints.

Pharmacokinetics

When taken orally, ibuprofen is almost completely absorbed from the gastrointestinal tract. Simultaneous reception food slows down the rate of absorption. Metabolized in the liver (90%). 80% of the dose is excreted in the urine mainly as metabolites (70%), 10% - unchanged; 20% is excreted through the intestines as metabolites.

Indications

inflammatory diseases joints and spine (including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, gouty arthritis);
moderate pain syndrome various etiologies(incl. headache, migraine, toothache, neuralgia, myalgia, postoperative pain, post-traumatic pain, primary algomenorrhea);
febrile syndrome with "colds" and infectious diseases;
created for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Release form

Film-coated tablets 200 mg and 400 mg.

Candles for rectal application for children 60 mg.

Gel for external use 5%.

Ointment for external use 5%.

Syrup or suspension for oral administration.

Effervescent tablets Ibuprofen - Hemofarm.

Instructions for use and dosage

Ibuprofen is prescribed for adults and children over 12 years old orally, in tablets of 200 mg 3-4 times a day. To achieve fast therapeutic effect the dose may be increased to 400 mg (2 tablets) 3 times a day. Upon reaching therapeutic effect the daily dose of the drug is reduced to 600-800 mg. morning dose taken before meals, washed down enough water (for faster absorption of the drug). The remaining doses are taken throughout the day after meals.

The maximum daily dose is 1200 mg (do not exceed 6 tablets in 24 hours). Take a second dose no more than 4 hours later. The duration of the drug without consulting a doctor is no more than 5 days.

Do not use in children under 12 years of age without medical advice.

Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can only be used if the child weighs more than 20 kg. The interval between taking tablets is at least 6 hours (daily dose is not more than 30 mg / kg).

Externally applied for 2-3 weeks.

The maximum daily dose for adults when taken orally or rectally is 2.4 g.

Side effect

NSAID gastropathy ( abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding);
irritation or dryness of the mucosa oral cavity;
pain in the mouth;
ulceration of the gum mucosa;
dyspnea;
bronchospasm;
hearing impairment: hearing loss, ringing or noise in the ears;
visual impairment: toxic injury optic nerve, blurred vision or double vision
dryness and irritation of the eyes;
swelling of the conjunctiva and eyelids (allergic genesis);
headache;
dizziness;
insomnia;
anxiety;
nervousness and irritability;
psychomotor agitation;
drowsiness;
depression;
confusion;
hallucinations;
heart failure;
tachycardia;
promotion blood pressure;
allergic nephritis;
skin rash (usually erythematous or urticaria);
skin itching;
angioedema;
anaphylactoid reactions;
anaphylactic shock;
fever;
allergic rhinitis;
anemia (including hemolytic, aplastic);
thrombocytopenia and thrombocytopenic purpura;
agranulocytosis;
leukopenia;
increased sweating.

Laboratory indicators:

bleeding time (may increase);
serum glucose concentration (may decrease);
creatinine clearance (may decrease);
hematocrit or hemoglobin (may decrease);
serum creatinine concentration (may increase);
activity of "liver" transaminases (may increase).

Contraindications

hypersensitivity to any of the ingredients that make up the drug. Hypersensitivity to acetylsalicylic acid or other NSAIDs, incl. anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or another NSAID; complete or incomplete syndrome of acetylsalicylic acid intolerance (rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
erosive and ulcerative diseases of the gastrointestinal tract in the acute stage (including peptic ulcer stomach and duodenum, Crohn's disease, ulcerative colitis);
inflammatory bowel disease;
hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis;
the period after coronary artery bypass grafting;
gastrointestinal bleeding and intracranial hemorrhage;
pronounced liver failure or active disease liver;
progressive kidney disease;
severe renal failure with creatinine clearance less than 30 ml / min, confirmed hyperkalemia;
pregnancy;
children's age up to 6 years.

Use during pregnancy and lactation

Contraindicated in pregnancy. Use with caution during lactation.

special instructions

Treatment with the drug should be carried out in a minimum effective dose, the shortest possible rate. During long-term treatment, it is necessary to control the picture of peripheral blood and functional state liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, general analysis blood (hemoglobin determination), fecal occult blood test.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities that require heightened attention, fast mental and motor reaction. During treatment, it is not recommended to take ethanol (alcohol).

drug interaction

The simultaneous use of ibuprofen with acetylsalicylic acid and other NSAIDs is not recommended. With the simultaneous appointment of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving low doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When administered with anticoagulant and thrombolytic medicines(alteplase, streptokinase, urokinase) at the same time increases the risk of bleeding. Simultaneous use with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding.

Cefamandol, cefoperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases plasma concentration cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Microsomal oxidation inducers (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication. Microsomal oxidation inhibitors - reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators, natriuretic and diuretic activity in furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect indirect anticoagulants, antiplatelet agents, fibrinolytics (increased risk of hemorrhagic disorders), enhances the ulcerogenic effect with bleeding of mineralocorticosteroids, glucocorticosteroids, colchicine, estrogens, ethanol (alcohol). Enhances the effect of oral hypoglycemic drugs and insulin, sulfonylurea derivatives. Antacids and cholestyramine reduce absorption. Increases the concentration in the blood of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Analogues of the drug Ibuprofen

Structural analogues for the active substance:

Advil;
ArtroKam;
Bonifen;
Brufen;
Brufen retard;
Burana;
Deblock;
Children's Motrin;
Long;
Ibuprom;
Ibuprom Max;
Ibuprom Sprint Caps;
Ibuprofen Lannacher;
Ibuprofen Nycomed;
Ibuprofen-Verte;
Ibuprofen-Hemofarm;
Ibusan;
Ibutop gel;
Ibufen;
Iprene;
MIG 200;
MIG 400;
Nurofen;
Nurofen for children;
Nurofen Period;
Nurofen Ultracap;
Nurofen forte;
Nurofen Express;
Pedea;
Solpaflex;
Faspik.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

With inflammation, fever, rheumatism and some other conditions, the use of ibuprofen is indicated. This drug is available in several forms, in this article we will consider a suspension for oral use.

Indications for the use of ibuprofen

An increase in body temperature of any genesis.
Pain syndrome of a moderate nature. Articular, dental, ear, headache, muscle and pain after musculoskeletal injuries.
Inflammatory and degenerative diseases of the musculoskeletal system (sciatica, arthritis, exacerbation of gout, bursitis ...).
Infectious diseases ENT organs.
Fever.

Contraindications

Ibuprofen, like other anti-inflammatory, antipyretic drugs, has some contraindications for use. These include:

individual intolerance to the components or the drug itself;
bronchial asthma;
diseases of the gastrointestinal tract in the acute stage (ulcers, erosion, colitis) and inflammation;
hyperkalemia;
children before three months;
progressive diseases of the kidneys and liver;
sucrase deficiency;
blood clotting disorders.

With care in exceptional cases, as directed, apply: to infants up to three months; with cirrhosis, renal / hepatic heart failure; infections, long reception NSAIDs or concomitant use of anticoagulants, prednisolone, warfarin, clopidogrel.

Attention! Ibuprofen is not safe drug. To avoid undesirable consequences contact a specialist!

Pregnancy and lactation

Mode of application

Shake before taking, use after meals with a non-hot liquid. The dosage is selected according to the age and weight of the person, it should be measured with the cup that comes in the package with medicinal suspension.

Maximum daily rate- 4 doses at the indicated dosage. Children under 12 years of age can take a suspension of 100 mg / 5.

3-12 months. Take 2.5 ml per dose, repeat (if necessary) after 6 hours.
1-3 years - 5 ml.
4-6 years - 7.5 ml.
6-9 years - 10.0 ml.
9-12 - 15 ml.
Children over 12 and adults suspension (200 mg / 5) - from 7.5 to 10 ml.

The maximum number of days of taking the drug is 5 days, if necessary, to extend the time of taking, you should seek advice.

Side effects

With excessive use of ibuprofen, the following symptoms may occur:

Pain in the abdomen and head, nausea, convulsive syndrome, lowering blood pressure, drowsiness, impaired renal function, coma, effects on the central nervous system and others.

Attention!

If you notice any of the adverse reactions while taking the drug, empty your stomach (by inducing vomiting, gastric lavage, taking Activated carbon), stop giving it to the patient and consult a doctor, describing the problem.

Composition, pharmacokinetics and pharmacodynamics

Anti-inflammatory and antirheumatic drug - a derivative of propionic acid, consists of ibuprofen and auxiliary components, including: lemon acid, sugar, orange flavor, water, glycerin, E110 and others. Suspension of orange color with a pronounced taste of orange.

Ibuprofen is effective for pain elevated temperature body, inflammatory processes and in rheumatism. When the suspension is taken orally, the drug is almost completely absorbed from the gastrointestinal tract, if taken separately from food: together with food, the absorption rate of ibuprofen slows down markedly. Most of it (70%) is excreted from the body as metabolites with urine or through the intestines (20), the rest (10%) is unchanged.

Other

Ibuprofen should be stored like all other medications, - in a dark place where there is no humidity and there is no access for children. Shelf life - 24 months before opening, after - 28 days.

Compound

Each tablet contains: active substance: ibuprofen - 200 mg; excipients: potato starch, magnesium stearate, calcium stearate, povidone, opadry ΙΙ (contains partially hydrolyzed polyvinyl alcohol, talc, macrogol 3350, lecithin, titanium dioxide (E 171)).

Description

Coated tablets, white color, with a biconvex surface.

Indications for use

Ibuprofen is used as an analgesic and anti-inflammatory drug in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still's disease), ankylosing spondylitis, osteoarthritis, and other non-rheumatoid (seronegative) arthropathies. It is indicated for the treatment of non-rheumatic inflammatory processes of the periarticular tissues: inflammation of the joint membranes, bursitis, tendonitis, tendovaginitis and back pain. Can be used to relieve pain syndrome with soft tissue damage (sprain). As an analgesic for the relief of mild to moderate pain in conditions such as dysmenorrhea, dental or postoperative pain, headache, including migraine.

Contraindications

Deficiency of glucose-6-phosphate dehydrogenase;

Hypersensitivity to ibuprofen;

Erosive ulcerative lesions gastrointestinal tract in the acute phase;

gastrointestinal bleeding;

- "aspirin" asthma and "aspirin" triad;

Hemorrhagic diathesis (Willebrand's disease, thrombocytopenic purpura, telangiectasia), hypoprothrombinemia, hemophilia;

Dissecting aortic aneurysm;

portal hypertension;

Vitamin K deficiency;

Pregnancy in III trimester and lactation;

Diseases of the optic nerve, scotoma, amblyopia, impaired color vision;

Arterial hypertension, heart failure stage III-IV according to NYHA;

Pathology vestibular apparatus, hearing loss;

Severe renal and hepatic insufficiency;

Children's age up to 6 years.

Dosage and administration

Apply inside, preferably between meals.

Adults appoint 400 - 600 mg (2-3 tablets) 3-4 times a day. At rheumatoid arthritis- 800 mg (4 tablets) 3 times a day. With algomenorrhea, 400 - 600 mg (2-3 tablets) with an interval of 4 - 6 hours. Maximum single dose is 800 mg (4 tablets), the daily dose is 2400 mg (12 tablets).

Children are prescribed at a dose of 5 - 10 mg / kg / day in 3 - 4 doses. The maximum daily dose is 20 mg / kg, with juvenile rheumatoid arthritis - up to 40 mg / kg. Children 6-9 years old (21-30 kg) 100 mg (½ tablet) 4 times a day, the maximum daily dose is 400 mg. Children 9-12 years old (31-41 kg) 200 mg (1 tablet) 3 times a day, the maximum daily dose is 600 mg. Children over 12 years old (more than 41 kg) 200 mg (1 tablet) 4 times a day, the maximum daily dose is 800 mg.

As an antipyretic at a body temperature of more than 38.5 ° C (in patients with a history of convulsions - at a temperature of more than 37.5 ° C). Assign at the rate of 5 mg / kg, at a temperature above 39.2 ° C - at a dose of 10 mg / kg.

Side effect

From the gastrointestinal tract: Peptic ulcer, perforation or gastrointestinal bleeding. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melena, hematemesis, ulcerative stomatitis exacerbation of colitis and Crohn's disease. Very rarely - pancreatitis.

From the side immune system : hypersensitivity reactions, anaphylaxis, asthma, bronchospasm or dyspnea, rash various types, itching, urticaria, purpura, Quincke's edema and, less commonly, exfoliative and bullous dermatoses.

From the side of cardio-vascular system : fluid retention, edema, hypertension and manifestations of heart failure.

From the blood system and lymphatic system : leukopenia, thrombocytopenia, neutropenia, agranulocytosis, aplastic anemia and hemolytic anemia.

From the CNS: insomnia, anxiety, depression, confusional state, hallucinations, optic neuritis, headache, paresthesia, dizziness, drowsiness.

Infections and infestations: rhinitis and aseptic meningitis (especially in patients with autoimmune disorders).

From the sense organs: visual disturbances and toxic optic neuropathy, hearing impairment, tinnitus and dizziness.

From the hepato-biliary system: liver dysfunction, liver failure, hepatitis and jaundice.

From the skin and subcutaneous tissue : Stevens-Johnson syndrome and toxic epidermal necrolysis (very rare), and photosensitivity reactions.

From the side of the kidneys and urinary tract: renal dysfunction and toxic nephropathy, including interstitial nephritis, nephrotic syndrome and kidney failure

General violations: general malaise, fatigue.

When using other medicines at the same time, it is necessary to consult a doctor before taking Ibuprofen!

Overdose

Symptoms: abdominal pain, nausea, vomiting, dizziness, lethargy, drowsiness, depression, headache, hypotension, convulsions, disorders heart rate, respiratory depression.

Treatment: drug withdrawal, gastric lavage (only within an hour after ingestion), activated charcoal, alkaline drink, symptomatic and supportive therapy (correction of the acid-base state, blood pressure).

Interaction with other drugs

May reduce the effect of antihypertensive drugs such as ACE inhibitors, beta-blockers and diuretics. Diuretics may also increase the risk of nephrotoxicity.

May aggravate heart failure, increase the effect of cardiac glycosides. May enhance the effect of anticoagulants such as warfarin.

Cholestyramine, when co-administered with ibuprofen, may reduce the absorption of ibuprofen in the gastrointestinal tract.

Simultaneous administration with methotrexate, lithium salts, aminoglycosides leads to a decrease in their excretion.

Cyclosporine and tacrolimus increase the risk of nephrotoxicity.

Co-administration of ibuprofen on the day of prostaglandin administration does not negative impact on the effect of mifepristone or prostaglandins on the maturation of the cervix and does not reduce the clinical efficacy of drug termination of pregnancy.

It is recommended to avoid the simultaneous use of two or more NSAIDs, including COX-2 inhibitors, as this may increase the risk of side effects. The concomitant use of ibuprofen and aspirin is not recommended due to possible increase side effects, including an increased risk of gastrointestinal ulcers or bleeding. Ibuprofen may inhibit the effect of low doses of aspirin on platelet aggregation.

Patients concomitantly taking fluoroquinolones may have an increased risk of seizures.

Ibuprofen may enhance the hypoglycemic effect of sulfonylurea drugs.

The risk of gastrointestinal bleeding increases with the joint appointment of antidepressants of the group selective inhibitors serotonin uptake, gingko biloba.

Zidovudine increases the risk of hematological toxicity when used concomitantly.

The simultaneous use of ibuprofen with voriconazole and fluconazole, leads to an increase in the time of action of ibuprofen by about 80 to 100%. Reduce the dosage of ibuprofen when co-administered with voriconazole or fluconazole.

Application features

Pregnancy. The use of ibuprofen during pregnancy is possible only under strict medical indications. The drug should be taken at the lowest effective dose. The use of ibuprofen may adversely affect pregnancy and intrauterine development fetus. Available increased risk miscarriage and malformations of the heart and gastrointestinal tract after the use of ibuprofen in early dates pregnancy.