Analogues of the drug obzidan. Obzidan - official instructions for use

"Obzidan" is a drug from the group of beta-blockers.

What is the composition and form of release of the drug Obzidan?

The drug is produced by the pharmaceutical industry in white tablet forms, they are round, with a risk on one of the surfaces and engraved with "0", the sign "4" is embossed on the other. The active compound is 40 milligrams of propranolol hydrochloride.

Excipients Obzidan: lactose monohydrate, magnesium stearate, sodium carboxymethyl starch, talc, gelatin, colloidal silicon dioxide. The pharmaceutical product is placed in blisters. Shelf life - 5 years. You can buy medication in the prescription department.

What is the effect of Obzidan?

The non-selective beta-blocker Obzidan has antianginal (relieves pain in the heart), antihypertensive effect, and also has an antiarrhythmic effect. The active compound blocks β-adrenergic receptors, reduces the formation of cAMP from ATP, after which the intake of calcium into the cell decreases.

The drug lowers the contractility of the myocardium, slows down the heart rate, in addition, it has a depressing effect on the conductivity and excitability of the heart muscle. The antihypertensive effect begins to stabilize after two weeks of course therapy. In addition, taking Obzidan helps prevent the development of headaches of vascular origin.

After oral administration, the drug is absorbed by 90%. The maximum concentration occurs within an hour to an hour and a half. Bioavailability is 30-40 percent. The drug has a rather high lipophilicity, the active compound of the drug accumulates in the brain, lungs, kidneys, and heart.

Communication with proteins - 95%. Biotransformable medicine in the liver. The half-life varies from three hours to five hours. Predominantly excreted by the kidneys, approximately 90 percent.

What are the indications for the use of Obzidan?

Tablets Obzidan instructions for use allows you to use in medicinal purposes in the following cases:

What are the uses and dosage of Obzidan tablets?

The drug Obzidan is recommended to be taken orally, they are not chewed, washed down with a small amount of liquid. At arterial hypertension the patient is recommended 40 mg twice a day. With insufficient hypotensive effect, the dose of the drug is increased to 120 milligrams. The maximum daily - 320 mg.

For the prevention of migraine, the drug Obzidan is prescribed 120 mg per day, the dosage is divided into three doses per day. Before taking the medication, the patient is advised to consult a doctor.

Overdose from Obzidan

Obzidan overdose symptoms: bradycardia, dizziness, arrhythmia, fainting, convulsions, decreased blood pressure, shortness of breath, cardiac arrest, cyanosis of the palms. The patient's stomach is washed, symptomatic treatment is carried out.

What are the side effects of Obzidan?

Reception means Obzidan provokes a number side effects: heart failure, dry mouth, myocardial conduction disturbance, nausea, arrhythmias, vomiting, decreased blood pressure, liquid stool, orthostatic hypotension, constipation, chest and epigastric pain, arterial spasm, change in taste, cold extremities, headache, rhinitis, insomnia, nasal congestion, and nightmares.

Other side effects: shortness of breath, bronchospasm, agitation, depression, laryngospasm, paresthesia, tremor, fatigue, hypoglycemia, weakness, dizziness, dry eyes, drowsiness, impaired visual acuity, confusion, short-term memory loss, decreased libido, hallucinations, keratoconjunctivitis, allergic reactions, decreased potency, muscle weakness and withdrawal syndrome.

special instructions

When prescribing the drug Obzidan, the patient must systematically control the pressure. With the development of depression medical measures it is recommended to stop.

How to replace Obzidan, what analogs to use?

Inderal, Vero-Anaprilin, Novo-Pranol, Anaprilin, Anaprilin-FPO, Propranolol Nycomed, Indicardin, Apo-Propranolol, Propranobene, Propranolol retard, Betakep TR, in addition, Prolol, as well as Propra-Ratiopharm.

Conclusion

Reception means Obzidan should be used on the recommendation of a qualified doctor.

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Angina pectoris, progressive angina pectoris, painless myocardial ischemia, arterial hypertension, arrhythmias, hypertrophic cardiomyopathy, cardiopsychoneurosis, digitalis intoxication, thyrotoxicosis, migraine, essential familial tremor.

Release form of the drug Obzidan

solution for injections 0.1%; ampoule 5 ml box (box) 10.

Pharmacodynamics of the drug Obzidan

Blocks beta1 and beta2-adrenergic receptors, has a membrane-stabilizing effect. It inhibits the automatism of the sinoatrial node, suppresses the occurrence of ectopic foci in the atria, AV junction, ventricles (to a lesser extent). Reduces the speed of excitation in the AV connection along the Kent bundle, mainly in the anterograde direction. Reduces heart rate, reduces the strength of heart contractions and myocardial oxygen demand. Decreases cardiac output, renin secretion, blood pressure, renal blood flow and glomerular filtration. Suppresses the reaction of baroreceptors of the aortic arch to lower blood pressure.

After taking a single dose, the hypotensive effect lasts for 20-24 hours. A single dose of prolonged forms is equivalent to taking several doses of propranolol hydrochloride. Hypotension stabilizes by the end of the 2nd week of treatment. At long-term use reduces venous return, has a cardioprotective effect (significantly reduces the risk of recurrent myocardial infarction and sudden death by 20–50%). In patients with a moderate form of arterial hypertension, it reduces the likelihood of developing coronary artery disease and brain strokes. With IHD, it reduces the frequency of attacks, increases exercise tolerance, and reduces the need for nitroglycerin. Most effective in patients young age(up to 40 years) with hyperdynamic type of blood circulation and with elevated content renin. Increases bronchial tone and uterine contractility (reduces bleeding during childbirth and in postoperative period), enhances the secretory and motor activity of the gastrointestinal tract. It inhibits platelet aggregation and activates fibrinolysis. Inhibits lipolysis in adipose tissue, preventing an increase in the level of free fatty acids(at the same time, the concentration of triglycerides in plasma and the coefficient of atherogenicity increase. Suppresses glycogenolysis, the secretion of glucagon and insulin, the conversion of thyroxine to triiodothyronine. Lowers intraocular pressure, reduces the secretion of aqueous humor.

Long-term administration (18 months) to rats and mice of doses up to 150 mg/kg/day did not reveal carcinogenic properties and adverse effects on fertility. At a dose of 150 mg / kg / day, 10 times higher than the MRDC, it had an embryotoxic effect (increased incidence of fetal resorption).

Pharmacokinetics of the drug Obzidan

When taken orally, it is rapidly and almost completely absorbed from the gastrointestinal tract (90%). Bioavailability is 30-40% (the "first pass" effect), depends on the nature of the food and the intensity of the hepatic blood flow and increases with long-term use(metabolites are formed that inhibit liver enzymes). Cmax in plasma is noted after 1-1.5 hours or 6 hours (for a prolonged form). Contacts proteins of plasma for 90–95%; T1 / 2 is 2-5 hours (10 hours for a prolonged form). The volume of distribution is 3-5 l / kg. accumulates in lung tissue, brain, kidneys, heart, passes through the placental barrier, penetrates into breast milk. Exposed to glucuronidation in the liver (99%). It is excreted in the bile into the intestine, deglucuronized and reabsorbed (T1 / 2 against the background of a course administration can be extended up to 12 hours). Excreted by the kidneys as metabolites.

Use of the drug Obzidan during pregnancy

Perhaps if the expected effect of therapy exceeds potential risk for the fetus. At the time of treatment should stop breastfeeding.

Contraindications to the use of the drug Obzidan

Hypersensitivity, AV block II–III degree, sinoatrial block, bradycardia (less than 55 bpm), sick sinus syndrome, arterial hypotension, acute and severe chronic heart failure, Prinzmetal's angina, cardiogenic shock, obliterating diseases vessels, bronchial asthma.

Side effects of the drug Obzidan

Weakness, dizziness, headache, paresthesia, cold extremities, dyspeptic disorders, conjunctivitis, skin rashes, itching.

Method of application and dose of the drug Obzidan

With hypertension - 40 mg 2 times a day. If necessary, the dose can be increased within 2-4 weeks to 80-160 mg 2 times a day. With angina pectoris, migraine, essential tremor - 20 mg 2-3 times a day. The dose can be increased within 1 week to 40 mg 4 times a day or up to 80 mg 2-3 times a day. Maximum daily dose- 240 mg for migraine and 480 mg for angina pectoris. With an arrhythmia hypertrophic cardiomyopathy, thyrotoxicosis - 10-40 mg 3-4 times a day (up to 240 mg / day).

Overdose of Obzidan

Symptoms: dizziness, bradycardia, arrhythmia, heart failure, hypotension, collapse, shortness of breath, acrocyanosis, convulsions.

Treatment: gastric lavage and the appointment of adsorbing agents, symptomatic therapy: atropine, beta-agonists (isoprenaline, isadrin), sedatives (diazepam, lorazepam), cardiotonic (dobutamine, dopamine, epinephrine) vasopressor drugs, glucagon, etc .; transvenous pacing is possible. Hemodialysis is ineffective.

Interactions of the drug Obzidan with other drugs

Barbiturates, nicotine increase the effect, cimetidine - weakens; enhances the negative inotropic effect of calcium antagonists, the negative dromotropic effect of cardiac glycosides, the hypotensive effect of antihypertensive drugs, the antiarrhythmic effect of lidocaine. Increases the likelihood of developing hypoglycemia on the background of insulin.

Precautions while using Obzidan

Treatment should be carried out under regular medical supervision. With prolonged use, the possibility of additional administration of cardiac glycosides should be considered. Reduces compensatory cardiovascular reactions in response to the use of general anesthetics. A few days before anesthesia, it is necessary to stop taking or choose an anesthetic with the least negative inotropic effect. Not recommended for intravenous administration to children. Elderly patients have an increased risk of CNS side effects. In case of impaired liver function, dose reduction and observation in the first 4 days of therapy are recommended. May mask symptoms of hypoglycemia (tachycardia) in patients diabetes taking insulin and other hypoglycemic drugs. It is possible to increase the severity of the hypersensitivity reaction and the lack of effect from usual doses epinephrine against the background of aggravated allergic history. During treatment, it is recommended to avoid the use of alcoholic beverages. Use with caution while driving Vehicle and people whose profession is associated with increased concentration of attention. Stop treatment gradually, for about 2 weeks.

Monitoring of patients taking propranolol should include monitoring of heart rate and blood pressure (at the beginning of treatment - daily, then 1 time in 3-4 months), ECG, blood glucose concentration in patients with diabetes mellitus (1 time in 4-5 months) . In elderly patients, it is recommended to monitor kidney function (1 time in 4-5 months).

The patient should be taught how to calculate heart rate and should be instructed to consult a doctor if the heart rate is less than 50/min.

Before prescribing propranolol to patients with CHF ( early stages) use digitalis and/or diuretics.

In "smokers" the effectiveness of beta-blockers is lower.

Patients using contact lenses should take into account that during treatment, a decrease in the production of lacrimal fluid is possible.

Patients with pheochromocytoma are prescribed only after taking an alpha-blocker.

In thyrotoxicosis, propranolol may mask certain Clinical signs thyrotoxicosis (eg tachycardia). Abrupt withdrawal in patients with thyrotoxicosis is contraindicated, as it can exacerbate symptoms.

When prescribing beta-blockers to patients receiving hypoglycemic drugs, care should be taken, since hypoglycemia may develop during prolonged breaks in food intake. Moreover, its symptoms, such as tachycardia or tremor, will be masked due to the action of the drug. Patients should be instructed that the main symptom of hypoglycemia during treatment with beta-blockers is increased sweating.

While taking clonidine, its reception can be stopped only a few days after the abolition of propranolol.

It is possible to increase the severity of the hypersensitivity reaction and the lack of effect from the usual doses of epinephrine against the background of an aggravated allergic history.

A few days before the general anesthesia chloroform or ether, you must stop taking the drug. If the patient took the drug before surgery, he should choose drugs for general anesthesia with a minimal negative inotropic effect.

Reciprocal activation of n.vagus can be eliminated by intravenous atropine (1-2 mg).

Drugs that reduce catecholamine reserves (for example, reserpine) can enhance the effect of beta-blockers, so patients taking such combinations of drugs should be under constant medical supervision to identify arterial hypotension or bradycardia.

You can not simultaneously use with antipsychotic drugs (neuroleptics) and anxiolytic drugs (tranquilizers).

Use with caution in conjunction with psychoactive drugs, such as MAO inhibitors, with their course use for more than 2 weeks.

In the case of the appearance in elderly patients of increasing bradycardia (less than 50 / min), arterial hypotension (systolic blood pressure below 100 mm Hg), AV blockade, bronchospasm, ventricular arrhythmias, severe violations liver and kidney function, it is necessary to reduce the dose or stop treatment. It is recommended to stop therapy with the development of depression caused by taking beta-blockers.

You can not abruptly interrupt treatment because of the risk of developing severe arrhythmias and myocardial infarction. Cancellation is carried out gradually, reducing the dose for 2 weeks or more (by 25% in 3-4 days).

Use during pregnancy and lactation is possible if the benefit to the mother outweighs the risk of side effects in the fetus and child. If necessary, admission during pregnancy - careful monitoring of the condition of the fetus, 48-72 hours before delivery should be canceled.

It should be canceled before the study in the blood and urine of catecholamines, normetanephrine and vanillylmandelic acid; titers of antinuclear antibodies.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

The drug Obzidan is widely used in cardiology practice. Its main action is to reduce blood pressure and elimination of symptoms certain diseases of cardio-vascular system. Regular intake of tablets allows you to maintain the patient's condition is normal for a long time.

The cardiological drug Obzidan is a medicine widely used in the treatment of diseases of the heart and blood vessels, it exhibits antiarrhythmic, tonic, antianginal, hypotensive effects on the body.

Medication with hypotensive action goes on sale in tablet form. Obzidan tablets are colored in White color. They tend to round form and beveled edges. On one side of the pill is a line that separates the numbers 4 and 0.

The active substance of the drug for oral intake is propranolol hydrochloride. The description of the tablets indicates that this component is contained in them in an amount of 40 mg. The composition also contains auxiliary compounds:

• Talc.
• lactose monohydrate.
• Potato starch.
• Gelatin.
• colloidal silicon dioxide.
• magnesium stearate.

On sale under this name you can still find a solution that is poured into ampoules. Each contains 5 ml of active ingredient.

Pharmacological properties

The drug helps to reduce the intensity and frequency of heart contractions. It reduces myocardial oxygen demand. Under the condition of the systematic use of the drug, a noticeable decrease in cardiac output and blood pressure. Positive changes will occur in terms of renin secretion and blood flow in the kidney area.

Patients who suffer from moderate hypertension can save themselves from high risk development of cerebral strokes and coronary disease hearts. If a person has already been diagnosed with the last disease, then the medication will allow him to withstand more serious physical exertion. This will significantly reduce the frequency of seizures.

As a result of treatment with Obzidan, an increase in the process of uterine contractility, as well as an increase in bronchial tone, is observed. Along with this, intraocular pressure normalizes and the secretory activity of the digestive tract starts.

A decrease in blood pressure in patients should be expected approximately 20-24 hours after taking a single dose.

Indications for use

When taking the medicine, blood pressure indicators decrease, the heart rate decreases, manifestations of coronary disease are eliminated

The drug must be taken in the presence of certain indications. Obzidan is prescribed to patients in whom the diagnosis has shown the presence of the following pathological processes:

1. Angina pectoris.
2. Tachycardia caused by various adverse factors.
3. Ciliary form of tachyarrhythmia.
4. Unstable angina.
5. Extrasystole supraventricular and ventricular forms.
6. arterial hypertension.
7. Essential tremor.
8. Migraine.
9. High risk of myocardial infarction.

The main indications for treatment with Obzidan were listed above.

Contraindications and restrictions

The remedy has contraindications, in which its use in therapeutic or preventive purposes is strictly prohibited. It's about about following states and diseases:

• arterial hypotension, which systolic pressure falls below 90 mm Hg. Art.
• Sinus form of bradycardia.
• Sinoatrial blockade.
• Acute form of heart failure.
• Acute myocardial infarction.
• Chronic heart failure that cannot be controlled.
• Cardiogenic shock.
• Weak sinus node.
• Pulmonary edema.
• Vasomotor rhinitis.
• Bronchial asthma.
• Diabetes.
• Spastic type of colitis.
• Individual intolerance to the components of Obzidan.

AT separate group includes conditions in which treatment with this drug is allowed, but subject to caution. It includes: pregnancy, hyperthyroidism, hepatic or kidney failure, psoriasis and allergic reactions that are present in history.

During pregnancy and breastfeeding

During pregnancy, the drug is contraindicated

The medicine is contraindicated in women who are pregnant or breastfeeding. Obzidan can harm the health of the baby.

In childhood

Among the main contraindications that medication with hypotensive action, applies to children and adolescence. Tablets and solution can only be prescribed to persons who have already reached the age of eighteen.

In old age

With caution, a course of therapy based on Obzidan should be carried out in older patients. age group(from 65 years old).

For impaired renal function

The drug may adversely affect the functioning of the kidneys. Therefore, in the presence of diseases of this organ, it is recommended to carefully select a dosage that is safe for humans.

For impaired liver function

Doctors prescribe the drug to people with liver failure in the minimum dosage that will give a positive therapeutic effect.

Side effects

The drug may cause side effect like nausea

A drug that is actively used in the treatment of high blood pressure can lead to the development of adverse reactions in a person. The medication causes the following side effects:

• Circulatory system: sinus bradycardia, hypotension, spasms of arteries that belong to peripheral organs, heart failure, arrhythmia.
• Digestive system: constipation, diarrhea, nausea, which is accompanied by the urge to vomit, impaired liver function, pain in the epigastric region.
• Central and peripheral nervous system: headaches, insomnia, inhibition of reactions, excessive agitation, confusion, hallucinations, tremors, asthenic syndrome, drowsiness.
• Respiratory system: rhinitis, nasal congestion, shortness of breath, laryngospasm, bronchospasm.
• Metabolism: hyperglycemia, hypoglycemia.
• Sense organs: drying of the mucous membranes of the eyes, decreased visual acuity, keratoconjunctivitis.
• Reproductive and urinary systems: decreased potency and libido.
• Skin reactions: hyperemia, psoriasis-like rashes on the body, exacerbation of psoriasis, exanthema.
• Hormonal system: decreased thyroid function.
• Allergic reactions: skin rashes, itching;
• Laboratory tests: an increase in the amount of bilirubin, leukopenia, thrombocytopenia, activation of liver transaminases.

Some patients complain that after taking the medicine they are worried about weakness, signs of arthralgia and lumbodynia. In some cases, there is a withdrawal syndrome.

Interactions with drugs and alcohol

When simultaneous reception drugs and alcohol there is a significant decrease in blood pressure

Not all medicines can be combined in one treatment course with Obzidan. Certain means are completely incompatible with it. This point must be taken into account when drawing up a complex therapy plan.

The use of the drug is unacceptable if the patient is already being treated with MAO inhibitors. As a result of the interaction of these drugs, a strong hypotensive effect is observed. Before switching from one drug to another, you must wait at least 14 days after taking the last pill.

Strengthening the effect of thyreostatic and uterotonic drugs, as well as reducing the effect antihistamines diagnosed when combined with Obzidan.

Due to its hypotensive effect, the drug can significantly weaken the effect of non-steroidal anti-inflammatory drugs, estrogens and glucocorticosteroid compounds.

Some types of cardiac glycosides and antiarrhythmic drugs are poorly combined with medication. Their interaction is fraught with an increase in the likelihood of a patient developing bradycardia or heart failure.

In the case of simultaneous reception antihypertensive medication and alcoholic beverages, there is a significant decrease in blood pressure. Therefore, patients are strongly advised to avoid such combinations in order to prevent the deterioration of their health.

Instructions for use

The tablets must be taken orally. Chewing them is not recommended. Wash down the medicine a small amount water.

If the patient requires treatment for angina pectoris or heart rate, then its initial dose will be 60 mg of Obzidan per day. It is divided into 3 doses. After that, you can increase the dosage to 80-120 mg per day. The maximum allowed to take no more than 240 mg of medication in one day.

Arterial hypertension is treated with Obzidan at a dose of 40 mg. It is taken 2 times a day. If a given dosage does not allow you to achieve the desired therapeutic result, then it is increased to 120 mg per day. They need to be divided into 3 doses. The biggest daily allowance cannot exceed 320 mg.

To prevent the development of migraine or to cope with the symptoms of essential tremor, you need to take the initial dose of Obzidan, which is 120 mg per day.

To prevent a recurrent myocardial infarction, the doctor will prescribe the patient to take between the first and fourth weeks after the illness, 120 mg per day. They are divided into 3 doses. After the dosage is reduced to 80 mg.

If the patient needs symptomatic treatment, then he needs to drink 40 mg of the drug 3-4 times a day.

Overdose

Exceeding the therapeutic dose medicinal product may be accompanied by convulsions

Failure to comply with the dose of the drug Obzidan, which is indicated by its instructions for use, leads to the development of an overdose. Given pathological condition recognized by its characteristic symptoms:

1. Collapse.
2. Labored breathing.
3. Severe hypotension.
4. Bradycardia.
5. Dizziness.
6. Arrhythmia.
7. Signs of heart failure.
8. Seizures.

special instructions

Throughout treatment, careful monitoring of the person's heart rate and blood pressure is required. Elderly people additionally need to check the work of the kidneys. This diagnostic it is desirable to carry out 1 time in 3-4 months.

Due to the intake of alcoholic beverages, the effect of the antihypertensive drug is greatly enhanced. A decrease in its effectiveness is observed when smoking.

Bioavailability is enhanced after a person eats enough protein fortified foods.

Termination treatment course should be done gradually. Otherwise, a person runs the risk of experiencing a withdrawal syndrome. Abrupt rejection from the drug leads to an increase pain syndrome during angina pectoris, worsens the tolerance of systems to physical activity and increases the severity of myocardial ischemia.

According to the rules, the abolition of the drug must be carried out in stages. It is required to reduce the current dosage by 25% every 3-4 days.

If the patient wears contact lenses, he should be warned that the drug reduces the production of tear fluid.

Price and analogues

In pharmacies in Russia, you can buy the drug for an average price of 57-65 rubles.

If the patient, for one reason or another, is not satisfied with the treatment with Obzidan, he can start using its analogues. The main substitutes for the drug are: Anaprilin (according to the active component), Visken, SotaGeksal, Sotalol Canon (according to the mechanism of action).

If the patient intends to change the drug, he must first inform the attending physician about this.

Obzidan refers to drugs with antiarrhythmic effects, and also helps to lower pressure, eliminate symptoms characteristic of coronary artery disease, reduce heart rate and the needs of the main organ human body in oxygen supply.

The mechanism of action of a drug related to non-selective beta-blockers on the body is:

• a decrease in the intracellular intake of an element such as calcium;
• providing a negative chrono-, dromo-, batmo- and inotropic effect;
• inhibition of conductivity and excitability, decrease in myocardial contractility;
• decrease minute volumes hearts;
• decrease in sympathetic stimulation of peripheral vessels;
• decrease in the activity of the renin-angiotensin system;
• providing a negative chronotropic and inotropic effect, accompanied by a decrease in myocardial oxygen demand;
• elimination of pathologies such as tachycardia, increased activity sympathetic nervous system, increased content of cAMP, arterial hypertension;
• decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers;
• decrease in the severity of myocardial ischemia and postinfarction mortality;
• headache prevention;
• reduction of tremor due to the blockade of β 2 -adrenergic receptors;
• increased atherogenic properties of blood;
• strengthening of uterine contractions;
• increased tone of the bronchi.

Release form

The active substance of Obzidan is propranolol hydrochloride. The drug is available in the form of tablets and injection solutions. Concentration active ingredient in one tablet reaches 40 mg.

On sale there are packages with 3 blisters of 20 tablets each.

Auxiliary components are presented potato starch, magnesium stereate, gelatin, colloidal silicon dioxide, sodium carboxymethyl starch, talc and lactose monohydrate.

Regarding the content of propranolol in injection solution, then its amount reaches 5 mg / ml. Sold in packs of 10 ampoules, the volume of each of which is 5 ml.

Instructions for use

Obzidan is indicated for:

• arterial hypertension;
• angina pectoris;
• unstable form of angina pectoris;
• sinus tachycardia;
• supraventricular tachycardia;
• atrial tachyarrhythmia;
• supraventricular and ventricular extrasystole;
• myocardial infarction;
• essential tremor;
• alcohol withdrawal;
• feelings of anxiety;
• frequent migraine attacks;
• diffuse toxic goiter;
• sympathoadrenal crises in diencephalic syndrome.

Price

To date, the drug is not registered in the territory Russian Federation, so it can not be found in network pharmacies. The medicinal composition can be purchased at such online stores as http://luxfarma.com (3,960 rubles for 100 tablets) and http://mospharm-delivery.rf (3,200 rubles for 100 tablets).

The high price is largely due to the foreign origin of Obzidan, because only the product of the German pharmaceutical company Actavis Deutschland GmbH is on sale.

Analogues

Due to the unavailability of Obzidan, search questions are at least effective analogues this drug are quite relevant. In this case, specialists prescribe to patients:

• Anaprilin- a drug based on propranolol. It is used to provide antianginal, hypotensive, antiarrhythmic effects on the body. It is produced in the form of tablets, the concentration in which the main active substance reaches 10 and 40 mg. Anaprilin is quite effective domestic analogue Obzidana, and also refers to cheap drugs. The price of Anaprilin is: 36 rubles (56 tablets, 40 mg), 46 rubles (112 tablets, 10 mg).
• Sotahexal- an antiarrhythmic drug based on sotalol hydrochloride. Pharmacological effects consists in blocking beta-adrenergic receptors, reducing heart rate, contractility myocardium, slowing down AV conduction, increasing the tone smooth muscle bronchi. Available in the form of tablets with a concentration of the main component of 80 and 160 mg. The cost of Sotahexal is 95 rubles (20 tablets, 80 mg), 140 rubles (20 tablets, 160 mg).
• Sotalol Canon- non-selective beta-blocker based on sotalol hydrochloride. Produced in the form of tablets, in which the concentration active ingredient reaches 80 and 160 mg. In pharmacies, products of the domestic pharmaceutical company Canonpharma are found, and prices range from 70 to 130 rubles and are determined by the concentration of sotalol.
• Hemangiol- beta-blocker based on propranolol. Available in the form of solutions for oral administration. The concentration of the active substance in the preparation is 3.75 mg / ml. Sold in bottles of 120 ml. The drug is manufactured by the French pharmaceutical company PIERRE FABRE MEDICAMENT PRODUCTION, and the average cost is 26,120 rubles.
• metoprolol- a cardioselective beta-blocker based on metoprolol tartrate, the concentration of which in one tablet is 50 and 100 mg. It is used to provide antiarrhythmic, antianginal and hypotensive effects. average price the drug is 72 rubles.
• Amiodarone- an antiarrhythmic drug of the third class, which also has antianginal, coronary dilatation, alpha- and beta-adrenergic blocking, thyrotropic and hypotensive effects. Available in the form of tablets, and the main active substance represented by amiodarone hydrochloride, the concentration of which in one tablet is 20 mg. average cost drug: 163 rubles.

Contraindications

You should not take the drug without a doctor's prescription, because the medicinal composition has numerous contraindications. According to the attached instructions, manufacturers focus on:

• hypersensitivity;
• cardiogenic shock;
• sinus bradycardia;
• cardiomegaly;
• arterial hypotension;
• pulmonary edema;
• myocardial infarction;
• vasomotor rhinitis;
• occlusive diseases affecting peripheral vessels;
• diabetes mellitus with ketoacidosis;
• metabolic acidosis;
• spastic colitis;
• bronchial asthma and tendencies to develop bronchospastic reactions;
• period of lactation.

Only after a comprehensive examination is it allowed to treat with Obzidan those patients who are diagnosed with pheochromocytomas, liver failure, Raynaud's syndrome, myasthenia gravis, depression, psoriasis, or have a history of allergic reactions.

The drug should be taken with caution in the elderly or childhood, as well as during the period of bearing a child.

Dosage

The optimal dosage should be determined only by the attending physician, taking into account the severity of the disease and the following recommendations manufacturers of Obzidan:

• If the patient is diagnosed with hypertension, for therapeutic purposes, the composition should be taken twice a day, 80 mg each. In case of absence therapeutic effect, which consists in lowering the pressure, it is allowed to increase the dosage to the level of 160 mg. The maximum allowable daily amount of Obzidan is 320 mg.
• Patients suffering from frequent migraine attacks are recommended to take the drug up to 120 mg per day for preventive purposes.
• Treatment of angina pectoris consists in daily doses of the drug up to 60 mg. The dosage can be increased over time to 80 or 120 mg, which should be divided into 2-3 doses. AT this case the maximum daily dosage is 240 mg.
• For the prevention of myocardial infarction, which is already in the patient's history, on the fifth day after the attack, you should start taking the drug in daily dosage about 120 mg, breaking this amount into three doses. The duration of this therapy should not exceed three days, after which the indicated dosage is recommended to be reduced to 80 mg.

Side effects

Obzidan is an effective antiarrhythmic drug, but its negative side is a number of side effects developing during treatment. Most often, patients experience:

• insomnia increased fatigue, dizziness, headaches, drowsiness, development depression, confusion, hallucinations, asthenia;
• impaired visual acuity, decreased salivation, dryness and soreness in the eyes;
• increased heart rate, myocardial conduction disorders, lowering blood pressure, pain in the chest;
• nausea, bouts of vomiting, epigastric pain, increased flatulence, impaired liver function, changes in taste preferences;
• rhinitis, bronchospasm;
• dysfunction of the thyroid gland;
• increased sweating, redness skin, partial hair loss, exacerbation of psoriasis;
• decreased potency and loss of sexual desire;
• allergic reactions in case of individual intolerance to the composition.

Compatibility

Leads to an increased hypotensive effect complex treatment Obzidan and MAO inhibitors. Joint methods will lead to the same result. medicinal composition and diuretics, hydralazine, reserpine and other antihypertensive drugs. But the development reverse effect contributes to the addition of Obzidan estrogen.

There may be a change in performance oral medications hypoglycemic type and insulin against the background of their combined administration with Obzidan. In this case, the developing symptoms indicating hypoglycemia may be latent, which will not allow timely detection of pathology.

Overdose

If the established maximum allowable daily dosages are unreasonably exceeded, symptoms characteristic of an overdose may develop. We are talking about dizziness, bradycardia, arrhythmias, heart failure, hypotension, collapse, breathing difficulties, convulsions.

If you observe these symptoms, you should contact qualified help, which will consist in gastric lavage, prescribing absorbent formulations to the patient. Symptomatic therapy consists of taking atropine, beta-agonists, drugs with a sedative effect.