Valerian is a sedative of plant origin. Valerian in tablets, drops, tincture. Instructions for use, medicinal properties, course of treatment, how to take during pregnancy

The composition of the drug includes the active ingredient - thick valerian extract .

In addition, valerian tablets contain some additional substances: the main one, croscarmellose sodium (primelose); potato starch, calcium stearate, gelatin.

Release form

Valerian extract is produced in the form of tablets for oral administration. The tablet may be yellow, brown. Valerian tablets are coated, the package may contain 10 or 50 tablets.

pharmachologic effect

The drug is of plant origin. Wikipedia indicates that valerian officinalis is a herbaceous, perennial plant.

Its other name is cat grass , since it is well known how valerian acts on cats. Catgrass, as valerian is sometimes called by another name, causes a pronounced excitation reaction in felines.

Features of the plant can be seen in the photo of valerian officinalis.

Valerian extract has a moderate sedative effect on the body. This effect is noted due to the presence in its composition of essential oil, the main content of which is the ester of isovaleric acid and borneol.

Ingredients also have a sedative effect. valerine and hotenin . As a result, there is a slow but stable sedative effect.

Under the influence of the drug, the processes of inhibition in the cerebral cortex are enhanced. It also increases the synthesis and secretion of GABA in the synapses of neurons in the cerebral cortex. Such an influence takes place only in the case of the total exposure to substances that are in the composition of valerian.

The extract helps to facilitate the onset of natural sleep. Valeric acid and valepotriates have a weak antispasmodic effect. Also, the active substances of valerian provide choleretic effect , activates the secretory activity of the gastrointestinal mucosa, slowing the heart rate and dilating the coronary vessels.

The therapeutic effect is noted if the treatment is carried out systematically and over a long period of time.

Valerian extract due to the presence in its composition actinidin unusually affects animals - felines.

Answering the question why cats love valerian, experts note that the smell of actinidin resembles the smell of certain substances contained in the urine of cats.

Pharmacokinetics and pharmacodynamics

There is little information on the pharmacokinetics of valerian extract tablets, since it is impossible to accurately identify the active principle of the drug.

After oral administration of 600 mg of dry extract of valerian, the highest concentration valerenic acid noted after 1-2 hours. Pharmacokinetics does not change if the drug is taken repeatedly.

Indications for use

The use of valerian tablets is indicated in the following cases:

• high degree of nervous excitement;
• and problems with falling asleep;
• vegetovascular dystonia ;
• functional disorders of the cardiovascular system (as part of complex treatment);
• spasms of the digestive tract (as part of complex treatment).

Before taking valerian tablets for pressure, stress (before an exam, etc.), it is imperative to consult a doctor who will tell you how to take the tablets, how much to drink, and whether you should do it.

Contraindications

Before you start taking this remedy, you should know its medicinal properties and contraindications. Do not take the drug if the following conditions and diseases are noted:

• high sensitivity to the components of the drug;
• fructose intolerance;
• lactase deficiency;
• sucrase/isomaltase deficiency;
• glucose-galactose malabsorption;
• first trimester;
• age up to 3 years.

Pregnant women should take into account the beneficial properties and contraindications, consult a doctor.

Side effects

During treatment, the following side effects of the tablets may appear:

• lethargy;
• and decrease in working capacity;
• (if long-term use is practiced).

Sometimes side effects may develop in the form of.

Valerian extract, instructions for use of tablets (Method and dosage)

The instruction for valerian tablets provides for taking 1-2 tablets three times a day immediately after meals. If necessary, the dose may be increased, but only under the supervision of a specialist. Treatment should continue for 2 to 4 weeks.

Instructions for the use of valerian tablets provide for repeated courses of therapy if necessary. The dose should not be adjusted for people who have impaired liver or kidney function.

How to take other types of medicine (bulgarian valerian, brown valerian, etc.) should be checked with the doctor who prescribes the treatment.

How to drink valerian tablets for a certain disease, the doctor who prescribes the therapy regimen should tell.

Overdose of Valerian

The consequences of an overdose of valerian tablets - a manifestation drowsiness , muscle weakness , lethargy and other signs of depression of the central nervous system.

In severe overdose, there may be bradycardia , . As a rule, such symptoms appear when taking large doses of the drug (a dose that is 20 times or more than usual).

However, how many pills cause such phenomena is individual for each person. The instructions do not indicate the lethal dose of the drug. Whether it is possible to die after a severe overdose depends on the state of health of the person.

In case of an overdose, you must immediately stop the drug, carry out gastrointestinal lavage, give the patient, as well as to prevent intestinal absorption of substances and cause a laxative effect. There is no specific antidote.

Interaction

Valerian extract in tablets can enhance the effect of sedative and hypnotic drugs, enhance the effect of antispasmodics.

Before taking valerian tablets, you must inform the doctor about all the drugs that the patient uses for treatment in parallel.

Terms of sale

You can buy valerian extract without a prescription.

Storage conditions

It is necessary to protect the tablets from the access of children, store them in a dry place, while the temperature should be 12-15 ° C.

Best before date

Tablets can be stored for 5 years.

special instructions

If the tablets are used for a long period of time, the effect on a person can lead to a decrease in psychomotor reactions. How long the drug acts in this way depends on the individual characteristics of the body.

While taking the medicine, one should take into account how valerian acts on a person, therefore, it is necessary to carefully manage the transport, as well as perform other actions that require the accuracy of the reaction.

Another name for the plant is cat grass, as it is called due to the fact that valerian causes a specific effect on animals. Many are interested in whether valerian is harmful to cats.

You can find out why cats like this medicine by examining its composition. Why the drug works this way, explains the presence of a substance in its composition actinidin .

As a rule, cats after valerian behave in a special way. But, answering the question whether it is possible to give a dog or whether it is possible to give a cat valerian, it should be noted that sometimes veterinarians even prescribe this drug to cats in small doses in order to increase vitality.

Unlike humans, cats are not sedated. There have been cases when an overdose led to the death of the animal. Sometimes a lethal dose for a cat is a relatively small amount of the drug, from which it is advisable not to keep the tablets in places where animals have access.

If you give valerian tablets for dogs, the remedy can provoke an animal allergic reactions .

Analogues

Coincidence in the ATX code of the 4th level:

Pharmacies sell a large number of various drugs based on valerian. In particular, these are Valerian P, Himalayan valerian, Bulgarian valerian and others. There are also a number of drugs with similar indications.

Which is better - Valerian or?

When answering the question of which is better - valerian or motherwort, it should be noted that the effect of motherwort on the human body is almost the same. However, in the treatment of neuroses and cardiovascular diseases, a more pronounced effect is noted when taking motherwort.

Those who are interested in whether this remedy raises or lowers blood pressure should take into account that when motherwort is taken, blood pressure indicators decrease.

Valerian for children

When discussing whether this drug can be given to children, it should be noted that valerian can be prescribed to children only according to the doctor's indications and taking into account age. Tablets for children under 3 years of age are strictly contraindicated; for children under 12 years of age, only a specialist can prescribe a dosage.

About what valerian is used for, how it affects children, how to take the drug, and whether valerian is harmful in each case, you should always consult with a pediatrician.

Valerian and alcohol

When discussing the compatibility of this drug with alcohol, it should be noted that while taking alcohol and tablets, mutual potentiation of effects is noted.

As a result, there is a pronounced lethargy of the central nervous system. Therefore, this combination is not recommended.

Valerian extract during pregnancy and lactation

Is it drinkable pregnant valerian preparations, depends on the period of the future bearing of the baby. Valerian tablets during pregnancy are prohibited if 1 trimester passes. For pregnant women at a later date (2nd trimester, 3rd trimester), the drug is allowed according to strict indications.

As a rule, valerian during pregnancy is prescribed as a relatively safe sedative, as abrupt changes in hormonal levels provoke a state of emotional instability in the expectant mother. During pregnancy, valerian can effectively relieve tension.

However, it should be noted that valerian tablets during pregnancy should be drunk strictly in the dosage prescribed by the doctor, since an overdose can adversely affect the developing fetus. The question of whether it is possible for pregnant women to take valerian should initially be discussed individually with a gynecologist.

Valerian can only be used after a doctor has approved the use of this drug. It should be borne in mind that with HB, drugs pass into breast milk, so the prescribed dosage must be very strictly observed.

It is also important to know that when breastfeeding a woman or a baby, as a result of taking the remedy, allergic reactions may occur, sleep disturbances in the baby are possible. Therefore, when breastfeeding, it is possible to practice taking the extract only according to the indications and after the appointment.

1. Pharmacological action

A sedative drug with antispasmodic activity. Therapeutic effects of Valerian:

• Strengthening the secretory activity of the digestive system;
• Choleretic action;
• Slow heart rate;
• Dilation of the arteries of the heart.

2. indications for use

• Conditions accompanied by increased nervousness;
• Difficulty falling asleep;
• High nervous excitability;
• Spasms of the digestive system;
• Violations of the activity of the cardiovascular system in a mild form;

3. How to use

• tablets: individual, associated with the severity of the patient's condition, determined by a specialist;
• infusion: one tablespoon of the drug four times a day;
• liquid extract: 20-30 drops of the drug four times a day.

4. Side effects

• Central nervous system: decreased performance, drowsiness, depression.

5. Contraindications

• Hypersensitivity to Valerian or its components;
• Individual intolerance to the drug or its components.

6. During pregnancy and lactation

Valerian can be used during pregnancy according to the testimony of a specialist. During lactation, the use of Valerian is possible according to the testimony of a specialist.

7. Interaction with other drugs

Significant drug interactions of Valerian with other drugs have not been identified.

8. Overdose

An overdose of Valerian has not been described.

9. Release form

Tablets, 20 mg - 10, 20, 30 or 50 pcs. Tincture - 10, 15, 25, 30 or 50 ml.

10. Storage conditions

Valerian should be kept out of the reach of children. Recommended storage temperature- within 12-25 degrees. Recommended shelf life- different, depending on the form of the drug and on its manufacturer, indicated on the package.

11. Composition

One tablet of Valerian:

• 20 mg thick valerian root extract;
• Auxiliary components.

12. Terms of dispensing from pharmacies

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* Instructions for medical use for Valerian are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

Valerian is a phytopreparation with a mild sedative effect. Available as a dry tablet extract. The main driving force of the drug is the essential oil, including bornylizovalerianate and borneol acetate. Other components of the extract are endowed with a sedative effect - valepotriates (valtrate and isovaltrate), substances resulting from their decay (valtroxal, baldrinal, homobaldrinal) and a couple of alkaloids in the face of valerin and chotenin. Valerian extract contributes to the immersion of a person in a natural normal sleep, protecting the body from external stimuli. Sedative action develops slowly, but steadily. Of great importance is the duration of the drug course and the regularity of the use of the drug: otherwise, the sedative potential of valerian is almost completely leveled. Valerian increases the affinity of GABA receptors for gamma-aminobutyric acid, which induces inhibition processes in the cerebral cortex. It is characteristic that a similar effect can be achieved only with the use of valerian extract: separately, its components (essential oil, valepotriates, sesquiterpenes) do not cause sedation when administered in isolation. The drug has a weak antispasmodic effect (especially with biliary dyskinesia of the hyperkinetic type), has a choleretic effect, stimulates the secretory activity of the mucous membrane of the digestive tract, causes moderate bradycardia, and increases the lumen of the coronary arteries.

The combination of natural compounds of the drug, using neurohumoral mechanisms and directly acting on the conduction system of the heart muscle, control the activity of the heart: slow down its rhythm, provide dilatation of the coronary arteries.

Valerian is indicated for hyperexcitability, somnological disorders, migraine headaches, mild functional disorders of the heart and digestive system. A single dose is 1 tablet, the frequency of administration is 2-3 times a day, the peculiarity of the intake is the recommendation to drink 100 ml of water, the best time to take it is after meals. The duration of the therapeutic course is determined by the doctor on an individual basis. He also establishes the optimal dose, guided by the age, history and individual characteristics of the patient. The drug is well tolerated and has a favorable safety profile. Side effects are manifested mainly when taking high doses and are not serious: they are lethargy, decreased performance, constipation. In rare cases, allergies are possible. Valerian potentiates the effect of hypnotics, anxiolytics (anti-anxiety drugs), analgesics. Combinations with cardiotonic and antihypertensive drugs are possible. Valerian is well combined with drugs used to treat cardiovascular pathology and diseases of the digestive tract.

Pharmacology

Means of plant origin. Causes a moderately pronounced sedative effect. The action is due to the content of essential oil, most of which is an ester of borneol and isovaleric acid. Valepotriates and alkaloids - valerin and chotenin - also have sedative properties. Valerian facilitates the onset of natural sleep. The sedative effect is shown slowly, but rather stably. Valeric acid and valepotriates have a weak antispasmodic effect. In addition, the complex of biologically active substances of valerian officinalis has a choleretic effect, enhances the secretory activity of the gastrointestinal mucosa, slows down the heart rate and dilates the coronary vessels. The regulation of cardiac activity is mediated through neuroregulatory mechanisms and a direct effect on automatism and the conduction system of the heart. The therapeutic effect is manifested with systematic and long-term course treatment.

Release form

10 pieces. - blister packs (2) - cardboard packs.
10 pieces. - blister packs (3) - cardboard packs.
10 pieces. - blister packs (5) - cardboard packs.
20 pcs. - cans (1) - packs of cardboard.
25 pcs. - cans (1) - packs of cardboard.
50 pcs. - cans (1) - packs of cardboard.

Valerian tablets are produced by different pharmaceutical companies, and, accordingly, the rules for the use of its various preparations differ, sometimes significantly. That is why before you start taking them, you must carefully study the instructions. Tablets may have different dosages, additional active ingredients and excipients. If some drugs can be taken 2 tablets 3 times a day, then for others 3 tablets per day are the maximum allowable dose.

Valerian tablets are considered safer than tinctures and therefore used in more cases.

Very often, mistakes in the use of valerian are made, wanting to get a quick sedative or hypnotic effect. After taking 1-2 tablets and not feeling better, the person decides to take the drug a second and third time. This still does not provide the desired result, but it can lead to an overdose of the drug, and that, in turn, can cause a deterioration in well-being.

It is important to remember that valerian is effective in long-term treatment, while a single dose of tablets has a mild effect that may go unnoticed. The drug can provide only a slight relaxation, contributing to calm and falling asleep. It does not have a "tranquilizing", strong sedative effect.

Valerian provides not only sedative and hypnotic effects, but also antispasmodic, hypotensive and others, due to which it is used for various diseases of internal organs. To know in which cases the remedy can be effective and how to use it correctly, you need to read the instructions specifically for the drug that you decide to take. However, various valerian-based products have general guidelines for use.

What diseases are prescribed valerian tablets

The main pharmacological properties of valerian are sedative and hypnotic, and to a lesser extent hypotensive, antispasmodic and choleretic.

In traditional medicine, valerian is most often prescribed as a mild sedative and hypnotic. It is used to reduce stress, psycho-emotional stress and anxiety. It is also recommended to drink the medicine for episodic or chronic insomnia and other sleep disorders, such as the inability to fall asleep, falling asleep too long, frequent awakenings at night and a feeling of dissatisfaction with sleep.

Insomnia and unexplained restlessness are among the main indications for taking valerian tablets.

Due to the hypotensive effect, as well as the effect on the coronary vessels and the heart, valerian is recommended to drink with hypertension, coronary circulation disorders and some other diseases of the cardiovascular system, in particular bradycardia and tachycardia.

Since valerian tablets also act as a mild antispasmodic, they are used for pathologies of the digestive tract, accompanied by spastic pains. The choleretic property makes it advisable to prescribe them for certain diseases of the liver and bile ducts.

Most often, valerian is prescribed in complex therapy for mild or chronic diseases, since it is not effective enough for complex diseases with severe symptoms. In the treatment of serious diseases, it is used as an aid.

Standard order of taking valerian tablets

The order in which valerian is used may depend on the dosage of the medication. Today, there are many valerian-based drugs on the pharmaceutical market, which differ both in the amount of active ingredient in one tablet and in the presence of various additional components.

The standard dosage regimen for valerian may only be suitable when using drugs in a dosage of 20 to 40 mg of root and rhizome extract. Such tablets are produced by the Ukrainian company Arterium, the Bulgarian Sopharma, the Russian Pharmstandard and some others. Depending on the required therapeutic effect, adults and children over 12 years old are prescribed 1-2 tablets 3-4 times a day, however, so that the daily dose does not exceed 200 mg of the active substance.

A fragment of the instructions for the use of one of the valerian preparations in tablets

Valerian tablets should be taken after meals and washed down with half a glass of water. It is not necessary to dissolve them.

On a note

The dosage of valerian, from which you can die, is not known. A case has been registered when a man intentionally ate 50 tablets of valerian (20 grams of active ingredient) and fainted after 30 minutes. He was hospitalized with severe intoxication of the body, however, thanks to timely medical assistance, after 24 hours he felt normal.

It should be borne in mind that valerian is very dangerous for cats and other pets, and even a few of its tablets can be fatal.

The course of treatment with valerian can range from 10 days to 1 month, since the effect of the tablets is fully manifested when taken regularly for a certain time. How many days you need to drink the medicine for a particular patient, the doctor should determine. It should be borne in mind that some drugs are not recommended to be used without a break for more than 14 days.

Drinking any valerian tablets for more than 1-2 months is not advisable, because due to the accumulation of a large number of active substances in the body, an overdose can occur and the risk of side effects of the drug increases. Also, according to the reviews of some experts, with a long continuous intake of valerian can be addictive. In cases where prolonged medication is needed, it is advised to take a break for at least one week after a month of treatment, and then start a new course.

A single dose of valerian is usually 1 or 2 tablets. However, wanting to calm down or fall asleep sooner, patients sometimes drink more. Doing this is not worth it, since increasing the dose has practically no effect on the effectiveness of the remedy, but increases the risk of overdose. A single dose of valerian provides a mild effect. It can cause a feeling of mild relaxation, which can help calm nerves and reduce emotional tension in some patients. At the same time, as a strong tranquilizing drug, valerian will not work with a single dose.

The standard amount of the drug for a single dose

On a note

It is believed that uncoated valerian tablets, which can be recognized by their dark and black color, are more quickly absorbed in the body and begin to act than preparations coated with yellow, green or brown shells. However, this does not affect the effectiveness of the remedy, since it is fully manifested only if the course of treatment is followed.

Features of the use of different preparations of valerian

Now in the pharmacy you can find many preparations of valerian. Tablets produced by different pharmaceutical companies can not only look different, but also have different composition, dosage, indications, contraindications and prices.

Consider the features of the most common drugs:

• Valerian, produced in Bulgaria by Sopharma, is available in a dosage of 30 mg. Tablets are used in adults and children over 12 years old, 1-2 pieces 3-4 times a day;
• Valerian Forte, Ukrainian company Arterium, contains 40 mg of active ingredient in 1 tablet. For children under 6 years of age, the drug is contraindicated, and up to 12 years of age it is allowed as prescribed by a doctor at a dosage of up to 3 tablets per day. For adults, the medicine is recommended 1-2 tablets up to three times a day;
• Valerian extract, also produced by Arterium, contains 20 mg of the active substance. It is prescribed 1-2 tablets up to four times a day;
• BAA "Evening Dragee" (popularly called night valerian), produced by the Russian company Parapharma, contains an extract of valerian, hop seedlings and peppermint. Its dosage is 200 mg. Dietary supplements take 1 tablet with meals 3-4 times a day. Due to the content of hops, it is contraindicated during pregnancy and breastfeeding;
• Phytocapsules "Valerian P", also produced by Parapharma, contain vitamin C. Take 2-3 capsules with meals two to three times a day. The recommended course of treatment with the drug is 14 days;
• The drug "Valerian P", produced in Belarus by Amateg, contains 56 mg of valerian extract and 15 mg of ascorbic acid. Recommend the drug to adults and children over 14 years old, 1-2 tablets up to 4 times a day;
• Valerian extra, also produced by the Belarusian company Amateg, contains a smaller amount of active ingredients: 10 mg of valerian extract, 5 mg of ascorbic acid and 0.007 mg of colloidal silver. They also take tablets 1-2 pieces up to 4 times a day with a course of treatment up to 14 days;
• Valeriana-Belmed, produced by the Belarusian company Belmedpreparaty, contains 200 mg of the active substance in 1 tablet. Tablets are drunk only as prescribed by the doctor three times a day, a maximum of 1 piece;
• Valerian extra, which is produced by the Russian company Biokor, also contains motherwort along with valerian. Tablets at a dosage of 130 mg are drunk 1-2 pieces up to three times a day;
• Valerian plus B6, manufactured by Vneshtorg Pharma, contains 40 mg of valerian extract and 2 mg of vitamin B6. Take the medicine 1 tablet with meals in the morning and evening for one month;
• Tablets Extract of valerian of the Russian company Evalar contain 20 mg of valerian extract and 5 mg of glycine. They are accepted according to the standard scheme.

Glycine is considered a fairly effective and completely safe sedative, an alternative to valerian.

There are many analogues of valerian preparations. How to use them correctly, you need to coordinate with your doctor, and also look at the instructions for a particular drug.

On a note

Valerian tablets in Russia can be bought for 7-10 rubles per tablet. The average price is 50-60 rubles per pack of 30 tablets. Valerian drops are somewhat cheaper. The price for a bottle of alcohol tincture is from 15 to 30 rubles.

Contraindications and side effects of various valerian preparations

Since valerian is part of various drugs, including complex ones, their contraindications may differ depending on the additional medicinal components.

The main contraindications to the use of valerian are:

• Allergy;
• Hypotension;
• Atherosclerosis;
• heart attack and stroke;
• Inflammatory diseases of the liver, kidneys and intestines;
• Transferred functional liver diseases;
• Age up to 3 years;
• Pregnancy and lactation.

It is not known how much and what set of active components of valerian will enter the child's body if a nursing mother starts taking appropriate drugs.

The drug is not recommended for use in hypotension, as valerian helps to lower blood pressure. With atherosclerosis, it can not be drunk because of the risk of blood clots. For the same reason, the drug is contraindicated in some other diseases of the heart and blood vessels.

Pregnancy and lactation are not a direct contraindication to the use of valerian. Some funds based on it are allowed during these periods as directed by a doctor. Recommendations to stop taking the drug are associated with the lack of clinical trials confirming the safety of the drug.

It is also impossible to give the drug to children under 3 years of age due to lack of data on efficacy and safety. For children from 3 to 12 years old, the doctor may prescribe the drug in small doses.
Valerian is considered a low-toxic drug, but in some cases it can cause side effects. The main ones are drowsiness, lethargy, apathy, loss of consciousness, depression, nausea, vomiting, diarrhea or constipation, nervous excitement and increased pressure.

Before you start taking valerian, you need to consult a doctor, and also carefully read the instructions for the drug.

Useful video: Composition and instructions for use of the tablet preparation of valerian

Can valerian help relieve stress?

Instructions for the medical use of the medicinal product

Valerian extract

Tradename

Valerian extract

International non-proprietary name

Dosage form

Coated tablets 0.02 g

One tablet contains

active substance - thick valerian extract - 0.02 g,

excipients: basic magnesium carbonate, potato starch, talc, gelatin,

shell composition: basic magnesium carbonate, beeswax, pigment titanium dioxide, quinoline yellow (E-104), sugar, talc, colloidal silicon dioxide, gelatin, sunflower oil, paraffin.

Description

Yellow film-coated tablets with a biconvex surface. The cross section shows two layers.

Pharmacotherapeutic group

Other sleeping pills and sedatives

ATC code N05CM09

Pharmacological properties

Pharmacokinetics

The pharmacokinetics of valerian has been poorly studied, which is due to the impossibility of accurately identifying the active principle of the drug. After ingestion

600 mg of dry extract of valerian, the maximum concentration of valeric acid (one of the likely active components) is reached in 1-2 hours and is 0.9-2.3 ng / ml. The half-life is 1.1 ± 0.6 hours. With repeated use of the drug, its pharmacokinetics do not change.

Pharmacodynamics

Herbal remedy. Has a sedative effect.

The action is due to the content of essential oil (0.2-2.8%), most of which is the ester of borneol and isovaleric acid - borneol acetate. Important components of the drug are also contained in the roots of valerian - sexviterpenes and monoterpenes: β-caryophyllene, valeranone, valerenal, valeric acid, as well as valepotriates (0.05-0.67%) - valtrate and isovaltrate. The main degradation products of valepotriates are baldrinal, homobaldrinal and valtroxal. Valerian extract increases the sensitivity of GABA receptors (gamma-aminobutyric acid receptors) to the effects of γ-aminobutyric acid, which enhances the processes of inhibition in the cerebral cortex. At the same time, an increase in the synthesis and secretion of GABA in the synapses of neurons in the cerebral cortex is observed. This effect is manifested only under the influence of the sum of substances contained in the valerian extract and cannot be reproduced with the isolated introduction of essential oil, sexviterpenes or valepotriates.

The sedative effect when using valerian manifests itself slowly, but quite stably and fully develops only with systematic and long-term course treatment. The speed of the body's reaction to external stimuli decreases, the onset of natural sleep is facilitated.

Valepotriates and valeric acid have an antispasmodic effect, have a mild choleretic effect, especially with spasm and hypermotor biliary dyskinesia.

The complex of biologically active substances of valerian through neurohumoral mechanisms and influence on the conduction system of the myocardium regulates cardiac activity - slows down the heart rate, slightly dilates the coronary vessels.

Indications for use

neurasthenia and conditions associated with prolonged neuropsychic arousal

sleep disturbances due to overexcitation, nervous stress

mild functional disorders of the cardiovascular system and digestive system (as part of complex therapy).

Dosage and administration

Adults: 40-80 mg (2-4 tablets) 3 times a day. If necessary, the daily dose may be increased to 1000 mg in several (usually 4-5) doses. In persons with impaired liver and kidney function, dose adjustment is not required.

The course of treatment is up to 1 month.

Side effects

Lethargy, depression, weakness, decreased performance

In some cases: allergic reactions may develop.

Contraindications

Hypersensitivity to valerian and to excipients of the drug

Children and adolescents up to 18 years of age.

Drug Interactions

Valerian potentiates the action of other sedatives, hypnotics, anesthetics, psychotropic drugs, and antispasmodics.

special instructions

Pregnancy and lactation

Taking valerian extract during pregnancy is not teratogenic. Given the side effects of the drug, care must be taken when using during lactation.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The lethargy and decrease in response to external stimuli caused by valerian preparations, as a rule, does not affect the patient's ability to drive a motor vehicle or other operator activities. However, caution is required, especially when valerian is used concomitantly with alcoholic beverages or other drugs that affect the central nervous system.

Overdose

Symptoms: when using excessively high doses (more than 20 times the maximum recommended dose), non-specific symptoms associated with depression of the central nervous system may occur: lethargy, lethargy, drowsiness. In severe cases, bradycardia and arrhythmia may occur.