Tinidazole side effects. Average cost in Ukraine. The drug "Tinidazole": what it treats

At infectious diseases powerfully helps antibacterial agent"Tinidazole". Patient reviews indicate that the drug acts against pathologies caused by a variety of pathogens, from protozoa to fungi. Previously, these tablets were used in their practice mainly by gynecologists. Now the scope of this drug has expanded and it is prescribed for various infections.

Composition and action of tablets

The drug is produced in the form of coated tablets of 500 mg. Them active ingredient- tinidazole. It acts against bacteria that can exist without oxygen (anaerobic microbes), as well as against protozoa and pathogenic fungi. Interacting with the causative agent of the disease, the drug destroys the DNA of the microorganism.

The medicinal substance of the tablets is rapidly absorbed from the gastrointestinal tract into the blood. The drug has the ability to accumulate in the body and reaches the required therapeutic concentration in 2-3 days. Nursing mothers need to remember that this remedy is able to penetrate into breast milk.

Indications and contraindications

The list of diseases in which the drug is indicated is quite wide. Instructions for the use of "Tinidazole" and patient reviews indicate the effectiveness of this remedy in the treatment of the following diseases:

• hepatic form of amoebiasis;
• amoebic dysentery;
• giardiasis;
• trichomoniasis;
• cutaneous leishmaniasis;
• pneumonia;
• soft tissue infections;
• wound infections;
• sepsis;
• peritonitis;
• postoperative infections;
• thrush;
• nail fungus;
• lung abscess;
• pyosalpinx;
• endometritis;
• ulcerative gingivitis;
• vaginitis.

The drug is also used against stomach infection caused by the microbe Helicobacter pylori, along with antibiotics and drugs containing bismuth.

The drug should not be taken in the first months of gestation. In the middle and at the end of pregnancy, the drug is prescribed only if the benefit to the mother exceeds possible risk for the future child. Breastfeeding mothers should not use this drug. If it is necessary to prescribe medication during lactation, then breast-feeding should be discontinued for the entire period of therapy and for another 3 days after the last dose of the drug.

Unwanted Effects

Such a powerful antibacterial agent can give unwanted effects. The instruction "Tinidazole" warns about this. Reviews of the drug indicate that the tablets are not always well tolerated. The most commonly observed side effects are:

1. From the side of the central nervous system there may be impaired coordination of movements, dizziness, seizures, degenerative lesions nerve fibers, trembling in the limbs.
2. Dyspeptic symptoms may occur: diarrhea, nausea, dryness and bad taste in the mouth.
3. The hematopoietic system may react negatively to taking the drug, which is manifested in an increase in the level of leukocytes.
4. Allergy sufferers may develop a rash severe cases- Quincke's edema.

The phenomena of overdose are extremely rare. This gives rise to severe vomiting, diarrhea, abdominal pain. There is no antidote, symptomatic treatment. In this case, there are no irreversible changes in the body, intoxication ends with a complete recovery.

Interaction with other medicines

Reception "Tinidazole" can be combined with treatment with antibiotics and sulfa drugs. It is undesirable to take this drug together with anticoagulants, it can cause bleeding.

During treatment with Tinidazole, alcohol should be avoided. This medicine not only interacts with ethyl alcohol, but also causes sharing sharp deterioration well-being: redness of the face, headache, nausea, drop in blood pressure, difficulty breathing. The reaction of "Tinidazole" with alcohol is similar to the reaction with alcohol of the drug "Esperal".

How to take pills?

Adults are usually prescribed 3-4 tablets per day. For children, the amount of medicine is calculated depending on the weight.

The duration of the course of treatment depends on the disease. If the drug is taken longer than a week, then you need to periodically take general analysis blood to control the number of leukocytes.

In the treatment of trichomoniasis, therapy using "Tinidazole" should be carried out not only by the patient himself, but also by his sexual partner. During the entire course of treatment and 3 more days after taking the last dose, alcohol should be excluded. During therapy, you should not drive a car and do work that requires heightened attention, since the tablets affect the reaction rate.

Storage conditions, price and analogues

The drug is stored at a temperature not higher than +25 degrees. Tablets can be used for 3 years. This expiration date provides instructions for the use of "Tinidazole". The prices of analogues and drug reviews will be discussed further.

"Tinidazole" - inexpensive drug, its cost in pharmacies is from 17 to 35 rubles. You can choose analogues for the active substance, these include the following medicines:

• "Tiniba".
• "Fazizhin".
• "Tinaprot".
• "Tizol".
• "Tinidazole Acry".
• "Vero Tinidazole".

All these drugs contain the same active substance and have the same therapeutic effect on the body. You can meet many positive feedback about the price of "Tinidazole". This remedy has a low cost and at the same time effectively cures infectious diseases.

You can pick up analogues and the effect on the body. Closest to "Tinidazole" is the drug "Trichopol". It contains the substance metronidazole. What is the best medicine? This question is often asked by patients.

"Trichopol" is a more toxic drug than "Tinidazole". Reviews say that this medicine often causes side effects. But at the same time, "Trichopol" does not affect the speed of reaction and concentration. It does not enhance the effect of anticoagulants and does not cause bleeding. "Trichopol" is available not only in the form of tablets, but also in the form of a gel, suspension and vaginal suppositories. The price of funds with metronidazole is 2 times higher than the cost of tablets "Tinidazole".

Tinidazole is a popular and cheap drug. Excellent analogue expensive drugs, which is not inferior in efficiency.

general characteristics

Tinidazole:

• has antibacterial and antiprotozoal effects;
• penetrates into Trichomonas and anaerobic microorganisms;
• destructively affects the DNA of harmful microorganisms.

Effective against many microorganisms and bacteria:

• lamblia; In addition to Tinidazole, they are used in the treatment of giardiasis.
• trichomonas;
• entamoeba;

It has an antiprotozoal effect on them.

After 2-2.5 hours after application, the activity of the drug begins. You can feel a significant improvement in well-being after 2-3 days from the moment of treatment. The drug very quickly begins to act in the body. It also easily penetrates into tissues.

The process of reducing the growth of anaerobic microorganisms can be enhanced by other drugs that have active hydroficated derivatives. Thus, the activity of the drug itself is increased. The combination of drugs should be consulted with the attending physician.

It is completely eliminated from the body within 15 hours after the last application:

• kidneys - excreted unchanged up to 25% of the drug.
• With stool and with dialysis.

Patients who want to get rid of worms often ask natural preparations with the least side effects. In such cases, I recommend this tool.

Composition and form of release

The active substance is tinidazole (500 mg). Film-coated tablets of 0.5 g.

Indications

Tinidazole is prescribed for such diseases and pathologies:

• trichomonas;
• giardiasis;
• amoebiasis;
• dysentery caused by amoebiasis;
• gingivitis;
• vaginitis (also non-specific);
• skin leishmaniasis.

The drug is effective in the presence infectious manifestations, which arose due to the influence of anaerobic bacteria. Among them: sepsis, peritonitis, abscess (including lungs), pneumonia. Skin wounds to prevent infection. For example, postoperative infections due to anaerobic microorganisms.

Treatment should begin immediately! Protect yourself and your loved ones!

Instructions for use of Tinidazole tablets

Reading the instructions that come with the tablets is a must! Even if the drug is taken as prescribed by a doctor.

Trichomoniasis in adults and children

Trichomoniasis in adults and children:

• Adults - 2 g per dose or 150 mg three times a day for 5 days. If necessary, you can replace the treatment with such a scheme - 150 mg of the drug twice a day for 7 days. For vaginal trichomoniasis, additional treatment for local therapy.
• The dosage for children is determined taking into account body weight - 57-75 mg per 1 kg. If necessary, the reception can be repeated with the same dosage.

Amoebiasis

In the treatment of amoebiasis, Tinidazole is taken as follows:

• In the treatment of intestinal amebiasis, adults are prescribed 2 g of the drug per day for 2-3 days. A treatment option is 600 mg Tinidazole twice a day for 5 days. If during this time the desired result from the treatment has not come, then the course is extended to 10 days.
• For children, the dose is determined, taking into account body weight - 50-60 mg of medication per 1 kg, once a day for 3 days.
• For the treatment of liver amoebiasis, 1.5-2 g per day is prescribed for 3 days. If this time is not enough, then the treatment is extended to 6 days. Another option effective treatment is to prolong the intake by reducing the dosage: for 10 days, 600 mg twice a day.
• Children are prescribed a dose with the calculation of 50-60 mg of Tinidazole per 1 kg of body weight, once a day for 5 days.

Vaginitis

In the treatment of nonspecific vaginitis, 2 g of the drug is prescribed once a day. Sometimes treatment requires a two-day application.

Gingivitis

Gingivitis, including ulcerative and acute form, treated with tinidazole with a single application with a dosage of 2 g.

For nail fungus

In this case, you need to consider:

• how badly the fungus hit the nail plate.
• age and weight of the patient.

Usually prescribed 2 g of medication per day for adults. Children are not recommended to exceed a dose of 75 mg per day. In some cases, the doctor may prescribe a dosage more than the instructions, due to a severe lesion. In this case, the person should tolerate the drug well.

Despite the fact that Tinidazole was originally developed for the gynecological area, it has been widely used from other bacterial localizations.

At the heart of the tool - bee propolis, which has a pronounced antibacterial, antiviral action. I like the drug because it is completely natural, on herbs, and this is very important for prevention."

Use of the drug in the second and third trimesters of pregnancy

The drug should not be taken in the first trimester of pregnancy. During the second and third trimester, treatment is possible if absolutely necessary. This is the case if the mother's health outweighs the risk to the fetus.

It should be noted that if there is a need to use Tinidazole during lactation, then feeding should be stopped. Since the drug passes into breast milk, there is a risk to the baby.

Contraindications

Contraindications:

• people who have hypersensitivity to tinidazole;
• with violations of hematopoiesis;
• diseases of the nervous system during an exacerbation;
• women in the first months of pregnancy and breastfeeding.

The drug is not taken simultaneously with alcohol. If a person suffers from nausea or vomiting, then treatment with Tinidazole should be postponed. And also it is not prescribed simultaneously with ethionomide.

Side effects

All medications have side effects.

From the use of Tinidazole, the most common are:

• lack of appetite, dry mouth and iron taste, nausea, vomiting, diarrhea;
• headaches, dizziness, severe fatigue, problems with coordination, neuropathy, convulsions;
• urticaria, skin itching, rash, Quincke's edema;
• transient leukopenia.

In case of overdose, symptomatic treatment is prescribed.

Special instructions during drug treatment

There are certain indications for treatment with this drug, but they depend on the disease itself, for example:

1. Trichomoniasis of the genitals both sexual partners should be treated. Otherwise, re-infection will occur.
2. During the period of treatment with this drug, ethanol should not be consumed. This may cause adverse reactions. It is worth noting that the use of this drug provokes changes in the color of urine. Do not be afraid, it will be dark in color.
3. At long-term use, namely more than 6 days, blood counts should be monitored. The attending physician usually prescribes necessary tests and determines the course of treatment.
4. Tinidazole is not prescribed for children under 12 years of age. No information about safe application this drug for the treatment anaerobic infections in children.
5. Since the drug affects the coordination of movements, contact with machinery should be limited, do not drive a car. If the patient's job requires high concentration attention, it is better to take sick leave.

Tinidazole and alcohol

In the case of the simultaneous use of alcohol and Tinidazole, spasms in the abdominal region may occur. Therefore, doctors strongly do not recommend this combination.

The price of the drug

As for the cost, this is one of the pluses this drug. The price of tinidazole is approximately 20-60 rubles. Since the drug is cheap, it is available to every patient. At the same time, it is recommended for high efficiency.

Tinidazole: consumer reviews

Patients who were treated with Tinidazole leave the following feedback:

Drug analogues

Tinidazole can be replaced for a specific reason with another drug.

Among the analogues are known:

• Tiniba;
• Vero-Tinidazole;
• Fazizhin;
• Tinidazole-Acre.

They are most often prescribed if a person suffers from hypersensitivity to this drug.

Tinidazole is cheap and available to everyone. It is popular with doctors and patients. It is important to remember that everyone's body is different. Therefore, the drug may not be suitable for everyone. Before taking, you should always read the instructions.

1 tablet contains 500 mg active ingredient tinidazole , as well as additional components in the form of microcrystalline cellulose, crospovidone, magnesium stearate, starch.

The shell contains elements: titanium dioxide, hydroxypropyl methylcellulose, polysorbate.

Release form

In tablet form.

pharmachologic effect

Antiprotozoal agent.

Pharmacodynamics and pharmacokinetics

It is a highly proliferative drug, capable of penetrating anaerobic microorganisms, Trichomonas . The mechanism of action is based on recovery with the help of nitroreductase, followed by inhibition of synthesis, disruption of the DNA structure. Tinidazole is active against Clostridium , fusobacteria, peptostreptococci.

Indications for use of Tinidazole

What are the pills for?

Indications for the use of the drug are: amoebiasis , , nonspecific vaginitis, ulcerative gingivitis in acute form. The drug is effective against anaerobic infections: abscess, sepsis, peritonitis, pyosalpinx, empyema, pneumonia. AT combination therapy used to eradicate Helicobacter pylori.

Contraindications

The drug is not prescribed for diseases of the nervous system of an organic nature, intolerance to tinidazole, oppression of bone marrow hematopoiesis, with. It is not used in pediatrics until the age of 12.

Side effects

Nervous system: , fatigue, dizziness, headaches, impaired coordination of movement, peripheral neuropathy , spasms, weakness in all body are seldom noted.

Digestive system: , dryness of the mucous membranes of the mouth, dyspeptic disorders, "metallic" taste in the mouth, loss of appetite.

Taking the drug Tinidazole may be accompanied by : angioedema , . Rarely observed transient leukopenia .

Application instruction of Tinidazole (Method and dosage)

Tinidazole is taken after meals, orally.

Giardiasis: once 2 grams, the dosage for children is calculated individually - 50 mg / kg. In case of ineffectiveness of the therapy, the course is repeated at the same dosage. Anti-lamblia therapy involves simultaneous treatment all family members, contact persons.

Urogenital trichomoniasis: 2 grams once, or 150 milligrams three times a day for 5 days, or 150 milligrams twice a day for a week. Treatment for vaginal trichomoniasis includes additional topical treatments.

Intestinal amebiasis: 600 milligrams twice a day for 5 days, or 2 grams per day for 3 days. If there is no effect on the 5th day, the treatment is extended up to 10 days.

Amoebiasis of the liver: three days, 1.5-2 milligrams per day, or 5-10 days, 600 milligrams twice a day.

Nonspecific vaginitis, ulcerative gingivitis: once 2 grams.

anaerobic infection(clostridia, fusobacteria, etc.): the first day 2 grams, the next days 1 gram per day, the course of treatment is 5-6 days.

Prevention of postoperative infectious complications : 12 hours before surgical intervention take 2 grams of the drug.

Instructions for use Tinidazole Akri is similar.

Overdose

In case of an overdose, an increase in the severity of the above side effects is recorded. There is no specific antidote for tinidozole, and dialysis is recommended.

Interaction

Tinidazole is not compatible with antibacterial drugs (cephalosporins, rifampicin, aminoglycosides ), sulfonamides . Phenobarbital helps speed up the metabolic process. Tinidazole is not prescribed with ethionamide . The drug enhances the effect indirect anticoagulants , reducing the dosage of the drug by half can reduce the risk of bleeding.

Terms of sale

Need a prescription.

Storage conditions

In a dry, dark place inaccessible to children at a temperature of 15-25 degrees Celsius.

Best before date

No more than three years.

special instructions

During the treatment period genital trichomoniasis it is necessary to treat the sexual partner.

Tinidazole contributes to the staining of urine in a dark color.

When taking the drug for more than 6 days, a control analysis of the state of peripheral blood is required.

There are no data on the safety of Tinidazole in the treatment of anaerobic infections in children under 12 years of age.

The drug affects the management complex mechanisms, driving vehicles, performing complex work.

With alcohol

When interacting medicinal product with ethanol, disulfiram-like reactions develop, complete abstinence from the use of alcoholic beverages during the entire period of treatment is recommended.

Analogues of Tinidazole

Coincidence in the ATX code of the 4th level:

An analogue can be called a tool Fazizhin , as well as Tinidazole-Acre .

Gross formula

Pharmacological group of the substance Tinidazole

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Tinidazole

A derivative of 5-nitroimidazole.

Pharmacology

Due to its high lipophilicity, it easily penetrates into Trichomonas and anaerobic microorganisms, where it is restored by nitroreductase and destroys bacterial DNA. Has antiprotozoal activity against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia. Has a bactericidal effect against most strains various kinds anaerobic microorganisms - Bacteroides spp.(incl. Bacteroides fragilis, Bacteroides melaninogenicus), Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Clostridium spp..

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. C max is achieved within 2 hours. C ss is achieved after 2.5-3 days of treatment. Plasma protein binding - 12%. Easily penetrates into various tissues and body fluids, passes through the BBB, the placental barrier, penetrates into breast milk. The apparent volume of distribution is about 50 liters. Undergoes biotransformation in the liver, mainly with the participation of CYP3A4. The main metabolites are pharmacologically active hydroxylated derivatives (suppress the growth of anaerobic microorganisms and may enhance the action of tinidazole). It is excreted by the kidneys (approximately 20-25% - unchanged) and with feces (approximately 12%). T 1/2 in adults is 10-14 hours. Excreted during dialysis.

The use of the substance Tinidazole

Protozoal infections: trichomoniasis, giardiasis, amoebiasis (including hepatic form and amoebic dysentery); infections of various localization caused by anaerobic bacteria, incl. peritonitis, endometritis, pyosalpinx, sepsis, wound infections (including prevention of postoperative anaerobic infections), skin and soft tissue infections, pneumonia, empyema, lung abscess; mixed aerobic-anaerobic infections (in combination with antibiotics); cutaneous leishmaniasis, nonspecific vaginitis, acute ulcerative gingivitis, eradication Helicobacter pylori (in complex therapy with bismuth preparations and antibiotics).

Contraindications

Hypersensitivity, organic diseases of the central nervous system, inhibition of bone marrow hematopoiesis, pregnancy (I trimester), breastfeeding, age up to 12 years.

Use during pregnancy and lactation

Contraindicated in the first trimester of pregnancy. In II and III trimesters possible if the expected effect of therapy exceeds potential risk for the fetus.

Breast-feeding should be stopped during treatment and for three days after the last dose (tinidazole is determined in breast milk within 72 hours of administration).

Side effects of the substance Tinidazole

From the nervous system and sensory organs: headache, dizziness, fatigue, weakness, impaired coordination of movements (including locomotor ataxia), dysarthria, peripheral neuropathy sometimes convulsions.

From the digestive tract: loss of appetite, dryness of the oral mucosa, metallic taste mouth, nausea, vomiting, diarrhea.

Allergic reactions: hives, pruritus, rash, angioedema.

Others: transient leukopenia.

Interaction

Compatible with sulfonamides and antibiotics (aminoglycosides, erythromycin, rifampicin, cephalosporins). It is not recommended to prescribe with ethionamide. Phenobarbital accelerates inactivation in the liver. Enhances the effect of indirect anticoagulants (to reduce the risk of bleeding, it is recommended to reduce their dose by 50%). Interacts with ethanol with the development of disulfiram-like reactions.

Tinidazole: instructions for use and reviews