Corvalol tablets: instructions for use. Corvalol: components, how it works, instructions for use, who is indicated, contraindications Corvalol in tablets, method of administration and dose

One tablet contains

active substances: ethyl ester of α-bromoisovaleric acid in terms of 100% substance 12.42 mg, phenobarbital in terms of 100% dry matter 11.34 mg, peppermint oil 0.88 mg;

excipients: lactose monohydrate, magnesium stearate, β-cyclodextrin, acesulfame potassium.

Description

Tablets of white color with a biconvex surface.

Pharmacotherapeutic group

Sleeping pills and sedatives. Barbiturates in combination with other drugs.

ATX code N05CB02

Pharmacological properties

Pharmacokinetics

When taken sublingually, absorption begins already in the sublingual region, the bioavailability of active substances is high (about 60-80%). The effect appears quickly (after 5-10 minutes). When taken orally, the action develops after 15-45 minutes and lasts for 3-6 hours. In persons who have previously taken barbituric acid preparations, the duration of action is reduced due to the accelerated metabolism of phenobarbital in the liver, where barbiturates cause enzyme induction. In the elderly and in patients with cirrhosis of the liver, the metabolism of Corvalol® is reduced, so their half-life is lengthened, which requires a dose reduction and lengthening of the intervals between doses of the drug.

Pharmacodynamics

Corvalol® is a sedative and antispasmodic drug, the effect of which is determined by its constituent components.

Ethyl ester of α-bromoisovaleric acid has a reflex calming and antispasmodic effect, due to irritation mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and an increase in inhibition phenomena in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and direct local antispasmodic action on vascular smooth muscle.

Phenobarbital suppresses the activating influence of the centers of the reticular formation of the middle and medulla oblongata on the cerebral cortex, thereby reducing the flow of excitatory influences on the cerebral cortex and subcortical structures. The decrease in activating effects has, depending on the dose, a sedative, tranquilizing or hypnotic effect. Corvalol® reduces excitatory effects on the vasomotor centers, coronary and peripheral vessels, lowering the total arterial pressure, relieving and preventing spasms of blood vessels, especially those of the heart.

Peppermint oil contains a large amount of essential oils, including about 50% menthol and 4-9% menthol esters. They are able to irritate the "cold" receptors of the oral cavity and reflexively expand mainly the vessels of the heart and brain, relieving spasms of smooth muscles, and cause a calming and mild choleretic effect. Peppermint oil has an antiseptic and antispasmodic effect, has the ability to eliminate flatulence.

Indications for use

- neuroses with increased irritability

- insomnia

- in the complex therapy of hypertension and vegetovascular dystonia

- mildly pronounced spasms of the coronary vessels, tachycardia

- intestinal spasms caused by neurovegetative disorders (as an antispasmodic drug).

Dosage and administration

Corvalol® is prescribed sublingually (under the tongue) or inside for adults, 1 tablet 2-3 times a day.

If necessary (severe tachycardia and spasm of the coronary vessels), a single dose can be increased to 3 tablets.

The duration of the drug is determined by the doctor depending on the clinical effect and tolerability of the drug.

Side effects

Corvalol® is generally well tolerated. In some cases, the following side effects may occur:

from the digestive tract: constipation, a feeling of heaviness in the epigastric region, with prolonged use - impaired liver function, nausea, discomfort in the stomach and intestines;

from the nervous system: weakness, ataxia, impaired coordination of movements, nystagmus, hallucinations, paradoxical arousal, decreased concentration, fatigue, slow reactions, headache, cognitive impairment, confusion, drowsiness, mild dizziness;

on the part of the hematopoietic organs: anemia, thrombocytopenia, agranulocytosis;

from the immune system: hypersensitivity reactions, including angioedema, allergic reactions;

from the side of the cardiovascular system: arterial hypotension, bradycardia; slowing of the heart rate.

from the skin and mucous membranes: Stevens-Johnson syndrome, toxic epidermal necrolysis;

other: difficult breathing.

Long-term use of preparations containing bromine can lead to bromine poisoning, which is characterized by such symptoms: depression of the central nervous system, depressive mood, depression, confusion, ataxia, apathy, conjunctivitis, rhinitis, lacrimation, acne or purpura.

Contraindications

- hypersensitivity to the components of the drug, bromine

- severe violations of the liver and / or kidneys

- hepatic porphyria

- severe heart failure

- severe arterial hypotension

- acute myocardial infarction

- diabetes

– depression

– myasthenia gravis

- alcoholism

- drug and drug addiction

- respiratory diseases with shortness of breath, obstructive syndrome

- pregnancy and lactation

- children and adolescents up to 18 years of age

Drug Interactions

Drugs of the central inhibitory type of action enhance the effect of Corvalol®.

The presence of phenobarbital in the preparation may induce liver enzymes and, accordingly, may accelerate the metabolism of certain drugs that are metabolized by these enzymes (including indirect anticoagulants, cardiac glycosides, antimicrobial, antiviral, antifungal, antiepileptic, anticonvulsant, psychotropic, oral hypoglycemic, hormonal, immunosuppressive, cytostatic, antiarrhythmic, antihypertensive drugs, griseofulvin, glucocorticoids, oral contraceptives), since their effectiveness will decrease as a result of a higher metabolic rate.

Corvalol® enhances the action of analgesics, local anesthetics and drugs that depress the central nervous system.

MAO inhibitors prolong the effect of phenobarbital. Rifampicin may reduce the effect of phenobarbital.

With the simultaneous use of phenobarbital with gold preparations, the risk of kidney damage increases.

With prolonged simultaneous use of phenobarbital with non-steroidal anti-inflammatory drugs, there is a risk of gastric ulceration and bleeding.

The simultaneous use of phenobarbital with zidovudine increases the toxicity of both drugs.

With simultaneous use with valproic acid, its effect is enhanced.

With simultaneous use with methotrexate, the toxicity of the latter increases.

Alcohol enhances the effect of the drug, also increases its toxicity. While taking the drug, you should avoid drinking alcohol.

special instructions

Concomitant consumption of alcoholic beverages should be avoided.

Care should be taken to prescribe the drug for arterial hypotension.

The drug contains lactose monohydrate, so if you have intolerance to some sugars, consult your doctor before taking this medicine.

The risk of developing Stevens-Johnson and Lyell syndrome is greatest in the first weeks of treatment. Long-term use is not recommended due to the risk of developing drug dependence, the possible accumulation of bromine in the body and the development of bromine poisoning. In cases where pain in the heart area does not go away after taking it, you should consult a doctor to exclude acute coronary syndrome. It is prescribed with caution for hyperkinesis, hyperthyroidism, hypofunction of the adrenal glands, decompensated heart failure, acute and persistent pain, acute drug intoxication.

Application in pediatrics

There is no experience in the treatment of children.

In the medicine cabinets of many families, you can find such a popular sedative as Corvalol. Many are accustomed to using this drug in the form of drops, but there is also such a drug form as Corvalol in tablets. Each patient can choose one or another drug depending on their preferences, but if necessary, using the medicine while traveling or at work is much more convenient. In addition, it is much easier to calculate the dose of the drug.

Compound

The main active ingredient in Corvalol is phenobarbital. This component has a relaxing effect on the human nervous system, improves sleep, relieves emotional stress and vasospasm. One tablet contains 7.5 milligrams of the active substance. Peppermint extract has a sedative effect on the body. One tablet contains 8.5 milligrams of plant oil. Among the auxiliary components, alpha-bromoisovaleric acid is a substance with an action similar to valerian. Corvalol also contains some excipients such as potato starch, cellulose, magnesium stearate and others.

Release form

The tablets are white, flat-shaped with bevelled edges. The medicine is produced in plates of 10 pieces. One carton pack contains 2 blisters.

pharmachologic effect

The therapeutic effect of tablets is due to their composition. The drug has a calming effect, helps relieve emotional stress, promotes the rapid onset of natural sleep. Peppermint essential oil expands the lumen of veins and capillaries, restores blood flow. It helps relieve spasm, normalize blood pressure. Getting on the mucous membrane of the mouth, the oil acts mainly on the vessels of the brain and heart muscle. In addition, mint normalizes the peristalsis of the digestive organs, relieving a person of flatulence and other unpleasant symptoms.

Who is shown the use of Corvalol

What helps Corvalol in tablets? This form of the drug is used among patients with the following conditions:

neuroses of various origins. At the same time, Corvalol is prescribed as one of the components of complex therapy;
in conditions characterized by increased excitability of the central nervous system;
during insomnia;
with pathologies of the heart and blood vessels;
with ischemic heart muscle disease, tachycardia, spasms of the coronary arteries;
in the early stages of hypertension;
for the treatment of patients with spasms in the organs of the digestive system;
to relieve the tone of the autonomic nervous system.

Corvalol is prescribed for insomnia, stress, cardiovascular diseases

Corvalol tablets are indicated for calming with severe emotional overstrain, stress. Corvalol also helps to cope with fatigue after heavy mental stress.

Method of administration and dose

How to take Corvalol tablets? The dose of the drug should be selected by the attending physician based on the study of the patient's medical history and diagnosis. Usually adults are prescribed 3 tablets per day. The method of application depends on the preference of the patient. The tablet can be placed under the tongue, slowly sucked or swallowed with plenty of water. Drinking Corvalol is allowed regardless of the time of eating. It is allowed to take no more than 6 tablets per day. The duration of therapy is selected individually by a specialist.

Important! During an attack of tachycardia, accompanied by rapid heartbeat and shortness of breath, a single dose of the drug can be increased to 3 tablets.

Are pills different from drops

Many patients are interested in whether the composition and effect of Corvalol tablets differ from drops? The composition and therapeutic effect of both forms of the drug are absolutely identical. Both drugs include the same active ingredient, so the effect of the drug is no different. How long does the medicine take to work? As with the drops, the effect after taking the tablets occurs after 10-15 minutes. For a quick result, it is recommended to put the tablet under the tongue.

Contraindications

Instructions for the use of Corvalol in tablets indicate such contraindications to the use of the drug:

intolerance to the constituent components of the drug;
severe kidney pathology;
liver disease, cirrhosis;
breastfeeding period.

It is forbidden to use the medicine among drivers and other patients whose work requires increased concentration. This is explained by the active ingredients that make up Corvalol, which have a calming and relaxing effect on the central nervous system.

Possible side effects

The drug very rarely provokes negative effects and complications. Some patients experience the following conditions:

nausea, rarely vomiting;
apathy, decreased concentration;
mild pain in the stomach;
slight headache, sometimes dizziness;
violation of the frequency of heart beats;
allergic rashes on the body.

Dyspeptic disorders that occur during treatment with Corvalol indicate the development of an overdose

If you do not stop taking the medicine in a timely manner, addiction or accumulation of bromine in the body may develop. The appearance of these side effects is evidenced by such manifestations as depression, unwillingness to communicate with other people, the appearance of nasal congestion, acne on the body, and nervous disorders.

To avoid such complications, Corvalol should be used only as prescribed by the attending physician, strictly observing the regimen and doses of the drug.

Drug analogues

The following analogues of the drug have a therapeutic effect similar to Corvalol:

drops Valocordin- a drug based on phenobarbital, used for insomnia, neuralgic disorders, sinus tachycardia, the initial stage of hypertension and other diseases;
corvaltab tablets- a drug with a vasodilating effect, a moderate antispasmodic, sedative effect. The drug is based on phenobarbital, includes mint oil and other auxiliary components. Among the indications for use are insomnia, tachycardia, the initial stage of hypertension, intestinal spasms caused by emotional outbursts, and other conditions;
Reladorm is a combined drug. Its active ingredients help to normalize sleep, relieve vasospasm and nervous strain. The composition of the drug includes diazepam, calcium cyclobarbital;
drops Barboval - have a hypotensive, antispasmodic, coronary dilating effect. For sleep disorders, conditions accompanied by tachycardia, high blood pressure, emotional stress, it is recommended to drink 10-15 drops of the medicine diluted in water. Sometimes the dose can reach up to 25 drops as prescribed by a doctor;
drops Corvaldin - a drug that has a sedative, antispasmodic, hypnotic effect. The basis of the drug includes ethyl bromisovalerianate, phenobarbital and mint oil. Corvaldin is indicated for insomnia, irritability, tachycardia, spasms of the intestinal tract and some other conditions;
Corvalol phyto - contains motherwort, ethyl bromisovalerianate, mint oil and other components. The tool has an antispasmodic, sedative effect. Taking the drug slows down the heart rate, while increasing heart contractions. A medicine is prescribed for diseases of the heart and blood vessels, nervous disorders, insomnia and other conditions;
capsules Corvalcaps- contains α-bromisovaleric acid, which has a calming, sedative effect, helps to eliminate the tone of smooth muscles. Phenobarbital relieves nervous tension, promotes rapid sleep. Corvalcaps is used for conditions associated with sleep disorders, nervous experiences, tachycardia, spasm of the coronary vessels, the initial stage of hypertension and other diseases.

Corvalcaps is one of the analogues of Corvalol, which has a similar composition and therapeutic effect.

Important! Analogues should be selected based on the examination of the patient and the diagnosis made by the attending physician, self-medication can cause indelible harm to the body.

Interaction with other drugs

When prescribing Corvalol, such features of its interaction with other medications are taken into account:

drugs that have a suppressive effect on the central nervous system increase the therapeutic effect of Corvalol;
Corvalol enhances the effect of painkillers;
phenobarbital reduces the effect of drugs metabolized in the liver (hormones, oral contraceptives, coumarin derivatives);
drugs based on valproic acid also enhance the effect of Corvalol.

During treatment with other drugs, Corvalol tablets should be taken only as directed by a specialist.

special instructions

Do not use the medicine for the treatment of patients suffering from severe angina attacks. When treating with the drug, you should abandon activities that require increased concentration of memory and attention. It is forbidden to combine tablets with the use of alcoholic beverages. If any side effects occur during therapy, the therapy must be stopped promptly, consult a doctor to prevent serious consequences.

Corvalol compatibility with alcohol

It has been proven that the combination of alcoholic beverages with Corvalol in any sequence can cause serious complications. This is explained by the fact that alcohol increases blood pressure, and Corvalol, on the contrary, stabilizes the heart rate. The imposition of such influences entails an imbalance in the body, which is accompanied by the destruction of the tissues of the heart muscle and blood vessels. In addition, if you drink a large dose of Corvalol immediately after taking alcohol, there is a risk of heart damage, rupture of the myocardial wall.

Is it possible during pregnancy

Despite the fact that Corvalol is a mild sedative medicine, it is not recommended to take it while carrying a baby. The risk of developing negative consequences in this situation outweighs the benefit. In the first trimester of pregnancy, it is forbidden to take any sedatives. The active components of the drug can adversely affect the developing nervous system of the fetus. In subsequent trimesters, the methods and dose of medication should be discussed with the doctor.

The appointment of Corvalol during pregnancy is carried out exclusively by a doctor

Application in pediatrics

Most pediatricians do not recommend the appointment of Corvalol for children under 12 years of age. Sometimes in emergency situations, it is allowed to take the drug once a day, the dose is determined by the doctor. For the treatment of nervous disorders, sleep disorders and other conditions that require the use of sedatives and sedatives, a special form of the drug has been developed - Corvalol kids. This medicinal product, which includes herbal ingredients, does not contain chemical and toxic additives.

Important! Corvalol kids has passed all the necessary quality checks, does not cause side effects, and can be prescribed for children of all ages.

Terms of sale

Corvalol tablets are dispensed from a pharmacy without a doctor's prescription. Despite this, it is categorically not recommended to use the drug on your own, since neglect of your health can provoke serious consequences, sometimes incompatible with life.

Instructions for use:

Prices in online pharmacies:

Corvalol is a drug with a sedative (sedative) effect.

pharmachologic effect

Corvalol is a combined remedy, the components of which determine its action: phenobarbital, ethyl ester of alpha-bromisovaleric acid, peppermint oil.

In general, the drug has a calming and antispasmodic, reflex vasodilating (vasodilating) effect, improves natural falling asleep.

Corvalol is produced in tablets, in the form of drops for internal use.

As a sedative and vasodilator, Corvalol is prescribed according to indications: sinus tachycardia, cardialgia, high blood pressure, insomnia, vegetative lability, neurotic conditions, hypochondriacal syndrome, irritability.

Intestinal and biliary colic is another indication of Corvalol, due to its antispasmodic effect.

According to the instructions, Corvalol should not be prescribed for severe renal, hepatic, during lactation, hypersensitivity. During pregnancy, the drug is used with caution.

During therapy, increased caution should be observed when driving vehicles, operating mechanisms, engaging in activities that require quick reaction, concentration.

The internal use of Corvalol before meals is shown, 15-30 caps, two to three r / day. Before taking the drops, dissolve in 30-50 ml of water.

According to the instructions of Corvalol, a single dose for tachycardia, vascular spasms can be increased to 30-40 caps.

Children are prescribed to take 3-15 caps.

The duration of treatment with Corvalol according to the indications in each case is determined individually.

Corvalol tablets are taken one, two tablets before meals, two to three times a day. With tachycardia, you can take up to three tablets at a time.

The use of Corvalol can cause dizziness, a decrease in heart rate, the ability to concentrate, drowsiness, and allergies.

Prolonged therapy with the drug can lead to addiction, dependence, bromism, "withdrawal" syndrome.

An overdose of Corvalol is manifested in depression of the nervous system, decreased pressure, ataxia, nystagmus, chronic bromine poisoning (rhinitis, hemorrhagic diathesis, depression, impaired motor coordination, apathy, conjunctivitis).

An overdose of Corvalol is treated with symptomatic therapy. With depression of the nervous system, nikethamide, caffeine are indicated.

Corvalol drops 25ml

Corvalol drops 25 ml

Corvalol drops 25ml

Corvalol 25ml drops

Corvalol drops 25ml

Corvalol drops 50 ml

Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is dangerous to health!

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Corvalol

The description is up to date 12.11.2015

Latin name: Corvalol
ATX code: N05CB02
Active substance: Peppermint Leaf Oil (Menthae piperitae foliorum oleum) + Phenobarbital + Ethylbromisovalerinate
Manufacturer: Pharma Start, Farmak PJSC (Ukraine), Pharmstandard-Leksredstva, Tatkhimpharmpreparaty, Marbiopharm, Altayvitaminy, Tver Pharmaceutical Factory, Dalkhimpharm, Permpharmacy, Yaroslavl Pharmaceutical Factory, ECOlab, Farmikon Pharmacy, Samaramedprom (Russia)

Compound Corvalol tablets: ethyl bromoisovalerianate , phenobarbital and peppermint leaf oil in proportions, respectively, of 12.42, 11.34 and 0.88 mg / tab, as well as excipients - lactose (in the form of monohydrate), β-cyclodextrin, acesulfame K, Mg stearate.

Compound Corvalol in drops: ethyl bromisovalerianate, phenobarbital and peppermint leaf oil in proportions of 20, 18.26 and 1.42 mg / ml, respectively, as well as ethanol 96%, purified water, stabilizer. One milliliter of solution is 26 drops.

The composition of drugs from different manufacturers may vary slightly. So, for example, in the composition Corvalola N(not available in tablets, only in the form of oral drops) in addition to these active ingredients, hop oil is also included (concentration - 0.2 mg / ml). Excipients of the drug: sodium acetate trihydrate, diluted acetic acid, purified water, 96% ethanol.

oral drops- 25 or 50 ml in bottles, package No. 1;
tablets- in blisters of 10 pieces, 1, 3 or 5 blisters in a pack.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Corvalol is a drug that has antispasmodic and sedative effect , as well as facilitating the onset of natural sleep.

Therapeutic effects are due to the properties of the drops / tablets included in the composition phenobarbital (funds from the group barbiturates ), ethyl bromoisovalerianate (sedative) and peppermint leaf oils.

Sedative effect contained in tablets / drops ethyl bromoisovalerianate similar to the effects of valerian (Valeriana), and its antispasmodic action It is realized due to stimulation of predominantly nasopharyngeal and oral cavity receptors, increased inhibition in the nerve cells of the cerebral cortex, as well as in its subcortical structures, a decrease in reflex excitability in the central parts of the somatic nervous system and the activity of the vasomotor center, direct antispasmodic action (local) to smooth muscle.

The latter manifests itself in the form of a decrease in the tension of the walls of blood vessels and internal organs, local anesthetics and vasodilating effects .

Phenobarbital suppresses the activating effect on the cerebral cortex of the centers of the reticular formation located in the middle and medulla oblongata, thus reducing the flow of excitatory influences on the subcortical regions and the cerebral cortex.

This in turn causes calming , tranquilizing or sedation (Severity of action depends on the dose).

Corvalol reduces excitatory effects on the centers of the central nervous system, which are involved in the regulation of vascular tone, as well as on peripheral and coronary vessels, while reducing the overall HELL and spasms of blood vessels, especially those of the heart.

Peppermint leaf oil contains a large amount of essential oils (including menthol (about 50%) and menthol esters (from 4 to 9%)), which have the ability to irritate the thermoreceptors (cold) of the oral cavity and reflexively dilate blood vessels (mainly of the brain and heart), while removing smooth muscle spasms, and have light choleretic and sedative effect .

Peppermint oil also has properties antiseptic and the ability to eliminate phenomena flatulence due to irritation of the mucosal receptors of the digestive canal and increased intestinal motility.

Absorption of the drug after sublingual administration begins already in the oral cavity. The active substances of Corvalol are characterized by high bioavailability, which varies from 60 to 80%.

A more rapid development of the effect (within five to ten minutes) is facilitated by holding the tablet in the mouth or taking drops on a piece of sugar.

Corvalol begins to act in 15-45 minutes, the effect lasts for three to six hours.

For people who have previously taken drugs barbituric acid , the duration of the effect is shortened due to the accelerated metabolism phenobarbital in the liver ( barbiturates induce liver activity enzymes ).

Reduced metabolism of Corvalol is observed in patients with liver cirrhosis and the elderly. In this regard, they have a longer half-life of the drug, which requires an increase in the intervals between taking tablets / drops or a decrease in dosage.

Indications for Corvalol's use

Indications for Corvalol's use in tablets

Corvalol tablets are prescribed for the treatment of:

Corvalol - what drops help?

Drops, like tablets, are used for disorders of the central nervous system , which are accompanied by increased irritability, in the early stages of development hypertension , at neurocirculatory dystonia , insomnia , moderately expressed tachycardia and to reduce symptoms spasm of the coronary vessels , provided that they are not pronounced.

The manufacturer's instructions list the following contraindications for the use of the drug:

intolerance to the components of oral drops / tablets;
hypersensitivity to bromine;
severe forms of CHF;
hepatic porphyria .

Caution should be exercised when prescribing the drug to patients diagnosed with epilepsy or liver pathology .

Side effects of Corvalol appear as:

As a rule, these symptoms disappear after a dose reduction or discontinuation of treatment with Corvalol.

Instructions for use Corvalol

According to the instructions for use, Corvalol drops are taken by mixing the drug with 50 ml of water or on a piece of sugar. The optimal time of admission is half an hour to an hour before meals.

How many drops of Corvalol you need to drip depends on the indications. The standard single dose is 15 to 30 drops. With spasm of the coronary vessels or severe tachycardia, a single dose may be increased to 40-50 drops.

How to take pills?

Corvalol tablets are taken orally or sublingually. Sublingual administration is preferred when you want to achieve the fastest effect.

The instructions for use of Corvalol in tablets indicate that the standard daily dose of the drug is 2-3 tablets. Single - 1 tablet.

If necessary (for example, to remove spasm of the coronary vessels ) the dose is increased to 3 tablets per dose. The permissible upper limit of the daily dose is 6 tablets.

How many times a day can I take the drug?

When asked how often Corvalol can be drunk, doctors answer that the frequency of applications depends on the indications. In some cases, a single dose of the medicine is sufficient, in some tablets / drops you should drink up to 3 rubles / day.

The duration of the course is determined depending on the tolerability and therapeutic efficacy of the drug.

Overdose of Corvalol

Overdose is the result of uncontrolled (frequent or too long) use of the drug. Ongoing/long-term treatment may lead to drug dependence, psychomotor agitation, withdrawal syndrome .

Symptoms of an overdose of Corvalol:

In severe cases, there are: arrhythmia , tachycardia , respiratory failure, drop in blood pressure. The most serious consequences of an overdose: collapse , coma , death.

Death occurs when taking 0.1-0.3 mg / kg of the drug. To intoxication results in taking more than 150 drops of oral solution. It should be noted that for children and the elderly, the toxicity threshold of Corvalol is much lower.

The action of Corvalol is enhanced with simultaneous use with drugs of the central inhibitory type of action, alcohol, valproic acid preparations .

Phenobarbital , inducing liver enzymes, thereby accelerating metabolism Drugs that are biotransformed in the liver, including: cardiac glycosides, anticoagulants of indirect action; antifungal, antiviral, antimicrobial, antiepileptic, psychotropic, anticonvulsant, hormonal, oral hypoglycemic, cytostatic, immunosuppressive, antihypertensive and antiarrhythmic drugs.

Prolongation of effects Phenobarbital contributes to the simultaneous use of MAOIs. Reducing their severity - reception Rifampicin .

When used Phenobarbital in combination with gold preparations, the risk of kidney damage increases, with NSAIDs (with prolonged use) - the risk of ulceration of the gastric mucosa and the development of bleeding, with Zidovudine - the toxicity of both drugs increases.

Corvalol enhances the toxic effects of Methotrexate.

Tablets and oral drops in vials of 15 ml and 25 ml belong to the group of over-the-counter drugs. Vials of 50 ml are dispensed by prescription.

The drug should be stored at a temperature not exceeding 25°C.

Tablets are suitable for use within 2, drops - within 2.5 years from the date of issue.

The presence in the composition of Corvalol phenobarbital may lead to the development Lyell's syndrome or Stevens-Johnson syndrome , which is most likely in the first weeks of the drug.

The droplets contain phenobarbital and ethanol (56 vol.%). The concentration of alcohol in the minimum dose of the drug (15 caps) is 254 mg, which corresponds to 2.7 ml of wine or 6.4 ml of beer.

When taking these substances, it is possible:

violations of coordination;
violation of the speed of psychomotor reactions;
dizziness;
drowsiness.

In this regard, the answer to the question of whether it is possible to drink Corvalol while driving is unequivocal - it is impossible. During the period of treatment with the drug (in any dosage form), you should also avoid working with mechanisms and activities that require increased attention and a high speed of motor and mental reactions.

Is Corvalol harmful - the benefits and harms of the drug

Why Corvalol is needed, everyone knows. The effectiveness of the drug is evidenced by a fairly large number of reviews left by patients. However, recently there is more and more information that the drug can not only treat, but also harm the body.

So, why is Corvalol harmful? Contained in tablets and drops ethyl bromoisovalerianate - this is antispasmodic , which, depending on the dose taken, can have sedative or hypnotic effect . The amount of dose required for the development of a hypnotic effect depends on the individual characteristics of the organism.

Entering the body when taking a standard dose of Corvalol (15-20 drops) phenobarbital causes vasodilation and causes mild sedation , without providing hypnotic effect .

Peppermint oil causes reflex vasodilation and antispasmodic effect , however, when consumed in a dose exceeding 25 mg, it inhibits intestinal motility and causes constipation.

In most countries, substances that provide the therapeutic effect of Corvalol are considered controlled substances (in the Russian Federation it is included in list III, which is the basis for restricting its circulation) and prohibited from importation. In particular, the drug is prohibited for import and sale in the United States and Lithuania.

According to some addicts, phenobarbital is a drug and should be avoided whenever possible due to the risk of addiction and drug dependence.

With regular use in high doses phenobarbital causes cognitive impairment (speech impairment, short-term memory disorders, unsteady gait), serious neurological disorders and withdrawal symptoms , suppresses sexual function.

Long-term use of Corvalol is also dangerous because of the risk of possible accumulation of bromine in the body and the development of poisoning with it.

Symptoms of poisoning can be mild, moderate or severe. The lungs manifest themselves in the form of: general weakness, drowsiness, lethargy, decreased muscle strength, absent-mindedness, blurred speech, confusion, apathy, ataxia, conjunctivitis, depressed mood, the appearance of purpura and acne , runny nose .

The consequences of moderate poisoning: a pathological increase in sleep duration, salivation, an increase in muscle weakness up to the development paresis , decrease in blood pressure, decrease in the volume of urine excreted, dilated pupils.

In the most severe cases, it develops barbituric coma . A person develops respiratory failure, reflexes cease to be determined, there is no consciousness, acute cerebrovascular insufficiency develops, the signs of which are:

drop in blood pressure;
the appearance of rales audible at a distance in the lungs;
tachycardia ;
increasing cyanosis of the skin, which spreads from the tips of the ears, nose, nasolabial triangle and ends with a general cyanosis .

progression of heart failure often ends pulmonary edema .

The lethal dose of the drug is 0.1-0.3 g / kg (on average, about 20 g). It should be remembered that taking more than 100 mg / kg leads to death. phenobarbital .

In case of mild poisoning, it is enough to wash the patient's stomach (to clean washing water), give him an enterosorbent (any, in the absence of intolerance) in a dose equal to a third of the highest daily dose. It is also advisable to use saline laxatives, a cleansing enema, and an enveloping drink.

Due to the danger of a rapid increase in the severity of the condition, it is imperative to call an ambulance.

With severe intoxication, when the patient has signs of a lack of cardiac activity, an indirect heart massage is performed before the doctor arrives and artificial respiration is performed.

The consequences of poisoning, even with timely assistance, can be quite serious - from severe forms dermatitis before acute heart, respiratory or renal failure .

The greatest number of deaths in case of drug poisoning is observed precisely from drugs, which include derivatives barbituric acid long action. The severity of the consequences is determined by the dose of the substance taken, the severity of the poisoning, and the timeliness of the measures taken.

Does Corvalol reduce blood pressure?

When it comes to treating patients suffering from pressure fluctuations, the question “Does Corvalol increase or decrease blood pressure?” very relevant.

Research scientists have shown that Corvalol lowers blood pressure. In this connection, in emergency situations, it can be used as an alternative to special medicines that are intended for the treatment arterial hypertension .

How to drink and how many drops to measure at elevated pressure?

If the pressure rises sharply, and the other antihypertensive drug not at home, doctors recommend measuring 45 drops of Corvalol oral solution in 100 ml of hot water and drinking this medicine in one gulp. Improvement is usually noted after about half an hour.

How to prepare a remedy for diseases of the heart and blood vessels at home?

At pathologies of the heart , hypertension , varicose disease peony, valerian, Corvalol, hawthorn, motherwort, mint and eucalyptus are very effective.

To prepare the medicine, alcohol tinctures are used in the following proportions: tinctures of valerian, motherwort, peony and hawthorn - 100 ml each, eucalyptus tincture - 50 ml, mint tincture - 25 ml, Corvalol - 30 ml, clove spice - 10 columns.

All ingredients are poured into a dark glass bottle, the bottle is corked and placed in a dark place for 2 weeks. The medicine should be infused at room temperature.

Take the remedy 3-4 rubles / day half an hour before meals, 30 drops for each dose, after diluting the indicated dose in 0.5 cups of water. The last dose should be before bedtime. They drink the medicine in courses lasting 30 days, with weekly intervals between them. Treatment is continued until improvement appears.

Combination motherwort , hawthorn and valerian contributes improvement of cerebral circulation , elimination of consequences stroke and heart attack , improve hematopoiesis, and also prevents thrombosis .

Which is better: Corvalol or Valocordin?

Valocordin is a drug based on ethyl bromoisovalerianate (18.4 mg/g), phenobarbital (18.4 mg/g), mint oil (1.29 mg/g), hop oil (0.18 mg/g), 96% ethanol (469.75 mg/g), purified water (411, 97 mg).

It can be seen that the difference in composition Valocordina and Corvalola is very insignificant. The only difference is that the former contains a small amount of hop oil, which has soothing and antispasmodic .

When asked how Valocordin differs from Corvalol, experts answer that the drugs are absolutely identical. Both of them quickly eliminate discomfort and pain in the heart, and, if used in a timely manner, can prevent angina attack and myocardial infarction .

Since Corvalol is a domestic drug, and Valocordin is produced by the German company Krewel Meuselbach GmbH, the former is a more affordable remedy (a bottle of drops Valocordina depending on the capacity, it costs from 130 to 300 rubles, while Corvalol drops can be bought for 11-40 rubles).

There is no experience with the use of Corvalol in pediatrics, and therefore the drug is not prescribed to children.

Alcohol compatibility

Alcohol enhances the effect of Corvalol. The drug is harmful to patients with alcoholism.

Corvalol and alcohol: consequences of simultaneous use

Simultaneous administration of the drug with alcohol primarily causes damage to hepatocytes and the development of a disulfiram-ethanol reaction.

Once in the blood, alcohol contributes to an increase in heart rate, increased pressure and excitation of the nervous system. Corvalol is taken in order to reduce the increased pressure and calm the heart. Thus, the combination of the active components of the drug with alcohol provokes imbalance and overload of the body.

Peppermint oil has vasodilating action and reduces blood viscosity. Since alcohol enhances the effect of the drug, drinking it in large quantities after taking Corvalol can provoke the development of internal bleeding and cerebral hemorrhage.

Another possible consequence of the use of such a combination is cardiac arrest.

Repeated mixing of Corvalol with alcoholic beverages can cause addiction that is much stronger than just alcohol addiction.

This is due to the fact that one of the components of the drug is phenobarbital - a substance from the group of derivatives barbituric acid , which, with prolonged use, is addictive and provokes the development of drug dependence.

Is it possible to drink Corvalol with a hangover?

With a hangover, the use of Corvalol is not only inappropriate, but also extremely dangerous. Accelerating the course of all metabolic processes in the body due to the active release of liver enzymes, the drug thereby contributes to the more rapid absorption of alcohol in the blood and enhances its destructive effect.

There is also an increase in the sedative effect, which in turn leads to a more pronounced hangover syndrome.

Against the background of alcohol consumption, the symptoms characteristic of an overdose of Corvalol are aggravated: severe weakness, inability to think coherently, apathy. The possibility of developing unexpected reactions is not excluded.

Corvalol during pregnancy and lactation

Is it possible to drink Corvalol during pregnancy?

The annotation to the drug states that both tablets and drops are contraindicated for pregnant women.

Application phenobarbital in the first three months pregnancy can provoke anomalies in the development of the fetus, and in the prenatal period - can cause a syndrome of respiratory disorders in the newborn.

Another component of Corvalol - mint oil - can cause an increase in the tone of the muscles of the uterus.

If the question arises whether it is possible for pregnant women to drink Corvalol, doctors answer that during pregnancy one should, if possible, refuse to take medications, and, if necessary, use the safest ones.

One tablet contains

active substances: ethyl ester of α-bromoisovaleric acid in terms of 100% substance 12.42 mg, phenobarbital in terms of 100% dry matter 11.34 mg, mint oil 0.88 mg;

Excipients: lactose monohydrate, magnesium stearate, β-cyclodextrin, acesulfame potassium.

Description

Tablets of white color with a biconvex surface.

Pharmacotherapeutic group

Sleeping pills and sedatives. Barbiturates in combination with other drugs.

ATX code N05CB02

Pharmacological properties

Pharmacokinetics

Pharmacodynamics

Corvalol® is a sedative and antispasmodic drug, the effect of which is determined by its constituent components.

Indications for use

- neuroses with increased irritability

- insomnia

- in the complex therapy of hypertension and vegetovascular dystonia

- mildly pronounced spasms of the coronary vessels, tachycardia

- intestinal spasms caused by neurovegetative disorders (as an antispasmodic drug).

Dosage and administration

Corvalol® is prescribed sublingually (under the tongue) or inside for adults, 1 tablet 2-3 times a day.

If necessary (severe tachycardia and spasm of the coronary vessels), a single dose can be increased to 3 tablets.

The duration of the drug is determined by the doctor depending on the clinical effect and tolerability of the drug.

Side effects

Corvalol® is generally well tolerated. In some cases, the following side effects may occur:

from the digestive tract: constipation, a feeling of heaviness in the epigastric region, with prolonged use - impaired liver function, nausea, discomfort in the stomach and intestines;

from the nervous system: weakness, ataxia, impaired coordination of movements, nystagmus, hallucinations, paradoxical arousal, decreased concentration, fatigue, slow reactions, headache, cognitive impairment, confusion, drowsiness, slight dizziness;

from the hematopoietic organs: anemia, thrombocytopenia, agranulocytosis;

from the immune system: hypersensitivity reactions, including angioedema, allergic reactions;

from the cardiovascular system: arterial hypotension, bradycardia; slowing of the heart rate.

from the skin and mucous membranes: Stevens-Johnson syndrome, toxic epidermal necrolysis;

other: labored breathing.

Long-term use of drugs containing bromine, can lead to bromine poisoning, which is characterized by such symptoms: depression of the central nervous system, depressive mood, depression, confusion, ataxia, apathy, conjunctivitis, rhinitis, lacrimation, acne or purpura.