Nootropil tablets are useful for children. Nootropil reviews of doctors. Is it possible to take phenotropil and nootropil in the course

Piracetam is the active ingredient of the drug.

The tablets contain 800 or 1200 mg of this substance. Additional elements: macrogol 6000, silicon dioxide, croscarmellose sodium, magnesium stearate.

Capsules of 400 mg of active ingredient. Additional substances: macrogol 6000, silicon dioxide, lactose monohydrate, magnesium stearate.

The oral solution contains 1 ml of 200 or 330 mg of the active substance. Additional elements of the composition are: sodium saccharinate, pure water, , sodium acetate, acetic acid, methyl parahydroxybenzoate, fragrances, propyl parahydroxybenzoate.

Nootropil solution in / in and / m contains 200 mg active substance per 1 ml. Auxiliary elements are: sodium acetate trihydrate, injection water, glacial acetic acid.

Release form

In tablets, capsules, as well as oral solution and solutions for intravenous and intramuscular use.

pharmachologic effect

Nootropic agent.

Pharmacodynamics and pharmacokinetics

The active substance is . The use of the drug Nootropil enhances the utilization of glucose, enhances the synthesis of phospholipids and RNA, increases the level of ATP in brain tissues, stimulates glycolytic reactions . The drug has a positive effect on brain tissues, facilitates the learning process, improves integrative work and brain activity, improves memory . Nootropil is able to suppress the aggregation of activated ones, does not have a vasodilating effect, but at the same time it has a positive effect on microcirculation and the speed of propagation of the excitation wave in the brain tissues. With brain damage on the background of intoxication, electric shock, the drug has a pronounced protective effect, reducing the severity of vestibular nystagmus, reduces delta activity and enhances alpha and beta activity by electroencephalogram . The drug improves cerebral blood flow, increases mental performance, improves conductivity between synapses in neocortical structures, and has a positive effect on interhemispheric connections. The therapeutic effect of the treatment develops gradually. The drug does not have psychostimulating and sedative effects.

The drug is rapidly absorbed, not metabolized, does not bind to blood proteins. Excreted by the kidneys unchanged.

Instructions for use of the drug Nootropil recommends prescribing the drug in neurology, narcology and psychiatry.

AT neurological practice the drug is used for pathology nervous system, accompanied by disturbances in the emotional-volitional sphere (for example,) and a decrease in intellectual-mnestic functions. The drug is prescribed after intoxication and traumatic injuries brain, with chronic cerebrovascular insufficiency (, expressed, speech, attention, memory disorders), with vascular pathology brain tissue, in comatose and subcomatose states, during convalescence in order to increase mental and motor activity, at residual effects circulatory disorders of the brain according to the ischemic variant.

Indications for the use of Nootropil in psychiatry: sluggish defective conditions (such as psycho-organic syndrome, ), asthenodepressive syndrome (with a predominance of ideational retardation, with senesto-hypochondriac disorders, asthenic pathology, with adynamia), nephrotic syndrome . Piracetam is prescribed in complex therapy depressive states resistant to antidepressants, in the treatment mental pathology, which takes place on "organically defective soil." The drug is recommended for prescription in case of intolerance to neuroleptics, antipsychotic drugs in order to eliminate mental, neurological and somatovegetative complications. The drug is prescribed for cortical form of myoclonus.

Nootropil in narcological practice used for cupping alcohol withdrawal syndrome , at acute poisoning , barbiturates , morphine, ethanol, with morphine withdrawal syndrome, chronic (in combination with intellectual-mnestic disorders, asthenia, persistent pathology of the psyche). The drug can be used as part of combination therapy during treatment sickle cell anemia .

In order to eliminate the consequences of perinatal damage to brain structures, to improve the learning process, with children's cerebral , mental retardation Nootropil can be used in pediatrics.

Contraindications

The drug is not used for hemorrhagic , with severe pathology of the renal system, with intolerance to the main substance piracetam. When carrying, heavy bleeding , after extensive surgical interventions, with pathology hemostasis and when Nootropil is prescribed with caution, assessing the possible risks.

Side effects

There are the following side effects against the background of treatment: vomiting, nausea, impaired concentration, imbalance, motor disinhibition, mental arousal , gastralgia, sleep disorders, anxiety, appetite disorders, stool disorders, increased sexual activity, convulsive syndrome , extrapyramidal disorders, headache, dizziness, . When diagnosed, there is a worsening of the course of the disease. Most often, side effects are recorded when the recommended dose of 5 g per day is exceeded.

Instructions for use Nootropil (Method and dosage)

The drug is prescribed intravenously, intramuscularly and orally.

Instructions for the solution

The initial dosage of the drug for parenteral intravenous administration is 10 g. In severe pathology, the drug is administered intravenously by drip up to 12 g per day, the duration of the infusion is 20-30 minutes. Upon reaching therapeutic effect the amount of the drug is reduced with a gradual transition to oral administration.

Tablets Nootropil, instructions for use

The drug is taken twice a day, daily dosage is 30-160 mg per 1 kg. It is possible to increase the frequency of administration up to 3-4 times a day if necessary. The course of treatment according to this scheme is up to 2-6 months.

At treatment of memory disorders, cognitive disorders administer medication by mouth early stages therapy three times a day, 1600 mg, in the future, the amount of the drug is reduced to 800 mg.

Treatment cerebrovascular disease in acute stage must start at as soon as possible from a dose of 12 g per day for two weeks, then switch to a dosage of 6 g per day.

Therapy cortical myoclonus start at 7.2 g per day with gradual increase the amount of active substance by 4.8 g per day every 3-4 days. The maximum dose is 24 grams in 24 hours.

Daily dosage at sickle cell anemia is 160 mg per 1 kg (4 doses). In the crisis period, the dose is increased to 300 mg per 1 kg.

In case of violations of the kidneys, the drug is used with caution. The dose is prescribed by the doctor.

How to take a drug to improve memory?

It is necessary to take the medicine 2 times a day. The following dosage is advised to improve memory - 8 ml of a 20% oral solution.

Overdose

Possible bloody diarrhea or abdominal pain at doses greater than 75 g per 24 hours. Treatment is as follows: gastric lavage or induction of vomiting, hemodialysis can be used.

Interaction

Nootropil reduces the risk of developing extrapyramidal disorders with simultaneous therapy with neuroleptics. The description of the drug Nootropil indicates its ability to increase efficiency indirect anticoagulants , antipsychotic drugs, psychostimulant drugs and thyroid gland .

Terms of sale

Presentation of a medical prescription is required.

Storage conditions

In a dry place inaccessible to children at a temperature not exceeding 25 degrees Celsius.

Best before date

Not more than 4 years.

special instructions

Treatment with Nootropil requires regular monitoring of the work of the renal, hepatic systems, the condition peripheral blood , level and residual nitrogen. Drug therapy can be combined with psychoactive drugs, drugs for the treatment cardiovascular disease. Treatment of acute lesions of tissues and structures of the brain is recommended to be carried out in combination with the methods of restorative medicine, detoxification therapy . At psychiatric diseases concurrently appoint psychoactive drugs. Abrupt withdrawal of the drug is unacceptable, especially in the treatment of patients suffering from the cortical form. myoclonus (due to high risk recurrence of seizures and seizures). With the development of such side effects as or excessive drowsiness, it is recommended to stop taking the medication in the evening. When Nootropil penetrates through special filtering membranes in the apparatus. Piracetam affects the ability to drive a vehicle.

The drug is not described in Wikipedia.

Alcohol compatibility

Alcohol does not affect the content of piracetam in serum, in turn, when taking 1.6 g of the active substance, the level of alcohol in the blood also did not change.

Nootropil's analogs

Coincidence in the ATX code of the 4th level:

Analogues are drugs: Biotropil , .

The price of Nootropil analogues is lower and higher. For example, Piracetam costs less.

Which is better: Nootropil or Piracetam?

Medicines are generics, that is, they contain one active substance, piracetam, and have a similar effect on the body. Piracetam drug - domestic production, and therefore it is cheaper, however, it is also considered less purified.

To improve brain activity child, he may be prescribed a drug called Nootropil. If it was prescribed to a baby, the mother is always interested in how this medicine affects the brain, whether it is possible to give this drug to children and how to take Nootropil in childhood.

Release form

Nootropil is produced in several forms:

• In capsules. One package contains 60 white capsules, each containing 400 mg of the active ingredient.

• In tablets. They are oval coated tablets. white color, produced in two dosages - 1200 mg (pack of 20 pieces) and 800 mg (pack of 30 pieces).

• In a solution that is taken orally. This is a syrup with an active substance concentration of 20% (1 ml of such a colorless thick liquid contains 200 mg of the active substance). The drug is available in a dark glass bottle with a volume of 125 ml, which is accompanied by a dosing cup.

• In ampoules of 5 ml. Each of them contains a 20% colorless transparent solution (in 1 ampoule 1 gram of the active substance, which corresponds to 200 mg in each ml). Ampoules are packed by 12 pieces in cardboard packs.

• In vials. This form of release is also represented by a 20% solution, but in a larger capacity, because one bottle contains 15 ml clear liquid(in one vial 3 g of active substance). One carton pack includes four bottles of Nootropil.

For ease of use, nootropil is available in various forms

Compound

Actively active substance in Nootropil is represented by piracetam. AT the content of the capsules is supplemented with lactose, magnesium stearate and colloidal silicon dioxide, as well as the synthetic additive macrogol 6000. The capsules themselves are made from purified water, gelatin and titanium dioxide.

In piracetam tablets, silicon dioxide and magnesium stearate are supplemented not only with macrogol 6000 and macrogol 400 additives, but also with titanium dioxide, HPMC stabilizer and crosscarmellose sodium.

In a solution intended for injection, in addition to piracetam, there is purified water, acetate and sodium chloride, as well as acetic acid. The oral solution contains not only piracetam and water, but also flavors (caramel and apricot), sodium saccharin, acetic acid and also glycerol. This form of release also includes preservatives, represented by methyl parahydroxybenzoate and propylhydroxybenzoate.

Video instructions for the use of nootropil can be viewed in the video:

Operating principle

This drug referred to as nootropics. Its active ingredient is a derivative gamma-aminobutyric acid(Russian abbreviation GABA, and foreign - GABA), therefore it is able to improve the functioning of the brain. Piracetam has a positive effect on attention, learning and memory. Taking such a remedy helps to increase the child's mental performance, and is also effective for the baby's speech with a delay speech development(ZRR).

The action of the drug is due to several mechanisms at once:

• Piracetam has the ability to improve metabolic processes in neurons.
• The drug affects the processes of excitation in the brain, changing their speed.
• Since the drug inhibits the aggregation properties of platelets and prevents erythrocytes from sticking together, it improves blood rheology, due to which circulation in the vessels of the brain becomes better. At the same time, the vessels themselves do not expand.

Nootropil is often prescribed for delayed speech development in crumbs.

If the child had hypoxia or intoxication that affected the brain, the use of Nootropil will protect the brain tissue and accelerate the recovery of the central nervous system. Under the influence of piracetam, the vestibular nystagmus in a child will be less prolonged and unexpressed.

For information on how to improve a child's memory, see Dr. Komarovsky's program.

Indications

In childhood, Nootropil is prescribed in such situations:

• When a child has a significant learning disability.
• For disorders vestibular apparatus and dizziness.
• If the child is in a comatose state, including coma caused by toxic effect or injury. Also, the medicine can be prescribed after coming out of a coma for better recovery.
• If the child had an ischemic stroke.
• With sickle cell anemia.
• If a child is diagnosed with cortical myoclonus, which is involuntary muscle contractions.

At what age is it allowed to take?

The use of Nootropil at the age of less than a year is not recommended, since studies on the effects of this drug on babies of the first year of life have not been conducted. The drug in the form of a syrup is prescribed at the age of 1-3 years. Babies over three years old can start giving pills. Capsules are given to children who can swallow them, for example, at the age of 8 years.

Therapy with such a drug is often long, for example, 5 months or even longer, but you should not be afraid of this, because the remedy is classified as harmless.

With a deterioration in learning, the child can take nootropil

Contraindications

The appointment of Nootropil is prohibited when:

• Renal failure.
• Individual intolerance to any of the components of the drug.
• Hemorrhagic stroke.
• Less than 1 year old.

The drug should be administered carefully if the child has problems with blood clotting or has been bleeding.

Side effects

• In some children, the use of Nootropil can lead to weight gain.
• Such a drug can also provoke the appearance of nervousness, drowsiness, depression or increased fatigue.
• High doses of the drug can interfere with digestion, causing abdominal pain, diarrhea, vomiting, or nausea.
• Nootropil sometimes causes allergies in the form of a rash, itching, swelling or dermatitis.
• Occasionally, the use of such a remedy leads to headaches, insomnia, anxiety, dizziness, agitation or hallucinations.

Why nootropic drugs are not as harmless as it might seem at first glance, see the next video.

Why can a baby be allergic to nootropil and other drugs and what to do in this case? The answer to this question is in this helpful video:

Instructions for use and dosage

The medicine is given during meals or before meals, washing down capsules, syrup or tablets with water or juice. If the remedy cannot be taken orally, the doctor prescribes injections. Instructions for use of the drug specifies that the duration of therapy with Nootropil is at least three weeks. If after 21 days from the start of treatment no positive changes have appeared or the condition has worsened, the drug is canceled.

The dosage for a child with a psychoorganic syndrome (decreased intelligence and memory problems) will be 4.8 grams of Nootropil in the first week (this is a daily dose, which is divided into 2-4 doses), and then daily dose decreases to 1.2-2.4 grams. If the child had a brain injury or neuroinfection, the drug is prescribed at a dose of 2.4 grams per day.

If Nootropil is prescribed for dizziness and balance problems, the dosage of the drug will be from 2.4 to 4.8 grams per day. Dosage for school age in order to improve learning, for example, at 9 years old or at 10 years old, is 3.3 grams per day. The drug is given during the school year.

Overdose

If you exceed the dose of the drug in 75 grams (we are talking about a solution that is taken orally), there are symptoms caused by excessive use of sorbitol. They are represented by pain in the abdomen and diarrhea mixed with blood. Treatment will be gastric lavage with induction of vomiting, as well as hemodialysis.

Interaction with other drugs

If you use Nootropil and at the same time give the child tetra- or triiodothyronine, the result may be problems with sleep and increased irritability. The use of Nootropil practically does not affect other drugs, because about 90% of piracetam leaves the child's body unchanged.

Terms of sale

Nootropil can be purchased at most pharmacies with a doctor's prescription. The price of a package of tablets of this medicine is on average 250 rubles, and syrup - about 300 rubles.

Storage conditions and shelf life

The medicine should be kept in a dry place with a temperature not exceeding +25°C. Children's access to the drug should be limited. The shelf life of Nootropil is 4 years.

Keep nootropil out of the reach of children

Nootropil (active substance - piracetam) is a nootropic drug that is a derivative of gamma-aminobutyric acid. Nootropil can be called a reference nootropic without any exaggeration. The mechanism of its action is associated with the impact on the course of metabolic and bioenergetic processes in neurons, the acceleration of the turnover of informational molecules and the stimulation of protein synthesis. The effect of piracetam on oxygen utilization and glucose metabolism is determined by the conditions in which the drug acts - aerobic or anaerobic. In the first case, nootropil increases oxygen consumption and glucose breakdown by an average of 30%. Under conditions of oxygen deficiency, the drug stimulates glycolysis due to the activation of the pentose phosphate pathway, resulting in the formation of one of the main energy sources for metabolism in the brain - NADPH. In addition, in anaerobic conditions nootropil increases ATP synthesis. At the cellular level, the drug interacts with the polar groups of phospholipids, forming mobile complexes. This ensures the restoration of the two-layer structure of the cell membrane and maintains its stability. Nootropil makes it easier various options synaptic transmission, affecting mainly the activity and density of postsynaptic membrane receptors (data were obtained during preclinical studies). Nootropil improves such cognitive functions as memory, attention, thinking, without having a psychostimulating (or, conversely, sedative) effect. Nootropil also affects rheological properties blood: in patients suffering from sickle cell anemia, the drug increases the ability of erythrocyte membranes to deform, thins the blood and prevents the formation of unstable erythrocyte aggregates - the so-called. "coin columns" characteristic of polyglobulia. In addition, nootropil reduces platelet aggregation (sticking together) without increasing / decreasing the number of the latter. In preclinical trials, it was found that the drug prevents vascular spasms and counteracts the substances that cause them.

AT clinical research nootropil prevented the adhesion of erythrocytes to the vascular endothelium and stimulated the secretion of prostacyclins.

After oral intake nootropil is rapidly and completely absorbed into gastrointestinal tract. After taking 3.2 g of the drug, the maximum concentration of the active substance in the blood plasma is reached after 1 hour. A tight snack slows down this process by an average of 20%. The half-life of nootropil is 4-5 hours (from plasma) and 8.5 hours (from cerebrospinal fluid). The route of administration of the drug into the body does not affect the half-life. From the body, nootropil is excreted by the kidneys unchanged. Renal failure increases the half-life of the drug, liver failure on the this indicator does not affect.

Nootropil is produced immediately in four dosage forms: tablets, capsules, solution for intravenous and intramuscular injection and oral solution. The dose is calculated based on the patient's body weight. Nootropil oral forms should be taken on an empty stomach or with meals. Reception of nootropil by patients with obvious violations of hemostasis, with large-scale surgical interventions, severe bleeding, insufficiency of kidney function should be carried out under careful and constant medical supervision. If, while taking nootropil, the patient has sleep disturbances, it is recommended to abandon the evening intake of the drug, combining it with a daytime intake.

Nootropil - "friendly" towards others medicines drug, however, it can also enter into some undesirable interactions. So, when it is combined with thyroid hormones, central effects: somnological disorders, irritability, anxiety, tremor, confusion. When nootropil is combined with CNS stimulants, potentiation of the effects of the latter can be observed. And, finally, when taking antipsychotics together with nootropil, the risk of extrapyramidal disorders increases.

Pharmacology

Nootropic drug, cyclic derivative of gamma-aminobutyric acid (GABA).

Available data suggest that the main mechanism of action of piracetam is not cell specific or organ specific.

Piracetam binds to the polar heads of phospholipids and forms mobile piracetam-phospholipid complexes. As a result, a two-layer structure is restored cell membrane and its stability, which in turn leads to the restoration of the three-dimensional structure of membrane and transmembrane proteins and the restoration of their function.

At the neuronal level, piracetam facilitates different types synaptic transmission, having a predominant effect on the density and activity of postsynaptic receptors (data obtained from animal studies).

Piracetam improves functions such as learning, memory, attention and consciousness without sedating or psychostimulating effects.

The hemorheological effects of piracetam are associated with its effect on erythrocytes, platelets and the vascular wall.

In patients with sickle cell anemia, piracetam increases the ability of red blood cells to deform, reduces blood viscosity and prevents the formation of "coin columns". In addition, it reduces platelet aggregation without significantly affecting their number.

Piracetam has been shown in animal studies to prevent vasospasm and counteract various vasospastic substances.

In studies in healthy volunteers, piracetam reduced the adhesion of erythrocytes to vascular endothelium and stimulated the production of prostacyclins by healthy endothelium.

Pharmacokinetics

Suction

After oral administration, piracetam is rapidly and almost completely absorbed from the gastrointestinal tract. After a single dose of the drug at a dose of 3.2 g Cmax is 84 mcg / ml, after repeated administration at a dose of 3.2 mg 3 times / day -115 mcg / ml and is achieved after 1 hour in blood plasma and after 5 hours in cerebrospinal fluid. Food intake reduces C max by 17% and increases T max up to 1.5 hours. In women, when taking piracetam at a dose of 2.4 g, C max and AUC are 30% more than in men.

Distribution and metabolism

Does not bind to plasma proteins.

V d of piracetam is about 0.6 l / kg.

In animal studies, it was found that piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia.

Not metabolized in the body.

Penetrates through the BBB and the placental barrier.

breeding

T 1/2 from blood plasma is 4-5 hours, from cerebrospinal fluid - 8.5 hours. T 1/2 does not depend on the route of administration.

80-100% of piracetam is excreted by the kidneys unchanged by renal filtration. The total clearance of piracetam in healthy volunteers is 80-90 ml / min.

Pharmacokinetics in special clinical situations

T 1/2 lengthens at kidney failure; at terminal stage chronic renal failure - up to 59 hours.

The pharmacokinetics of piracetam does not change in patients with hepatic insufficiency.

Penetrates through the filtering membranes of hemodialysis machines.

Release form

White or almost white film-coated tablets, oblong, with a dividing transverse risk on both sides; engraving "N" on one side of the tablet to the right and left of the risks.

Excipients: silicon dioxide, magnesium stearate, macrogol 6000, croscarmellose sodium; Opadry Y-1-7000 (titanium dioxide (E171), Macrogol 400, Hypromellose 2910 5cP (E464)), Opadry OY-S-29019 (Hypromellose 2910 50cP, Macrogol 6000).

15 pcs. - blisters (2) - packs of cardboard.

Dosage

The drug is administered orally, during a meal or on an empty stomach, drinking liquid.

Symptomatic treatment of psychoorganic syndrome: 2.4-4.8 g / day in 2-3 doses.

Treatment of dizziness and associated imbalance: 2.4-4.8 g / day in 2-3 doses.

Treatment of cortical myoclonus begins with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until maximum dose 24 g / day in 2-3 doses. Treatment is continued throughout the entire period of the disease. Every 6 months, attempts should be made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g / day every 2 days.

Prevention of sickle cell vaso-occlusive crisis: the daily dose is 160 mg/kg of body weight, divided into 4 equal doses.

Treatment of dyslexia in children (as part of complex therapy): the recommended daily dose for children from 8 years of age and adolescents is 3.2 g, divided into 2 doses.

For patients with impaired renal function, the dose should be adjusted depending on the size of the CC.

For men, CC (ml / min) \u003d x body weight (kg) / 72 x serum creatinine (mg / dl);

In elderly patients, the dose is adjusted in the presence of renal failure; with long-term therapy, control is necessary functional state kidneys.

For patients with impaired function and kidney and liver, the drug is prescribed in the same way as for patients with impaired renal function only.

Overdose

Symptoms: a single case of the development of dyspeptic phenomena in the form of diarrhea with blood and pain in the abdomen was registered when the drug was taken orally at a daily dose of 75 g. Apparently, this was due to the use of a large total dose of sorbitol, which was previously part of dosage form oral solution.

Treatment: immediately after a significant overdose by ingestion, you can wash the stomach or induce artificial vomiting. There is no specific antidote. The efficiency of hemodialysis is 50-60%.

Interaction

The possibility of changing the pharmacokinetics of piracetam under the influence of other drugs is low, because 90% of the drug is excreted unchanged in the urine.

With simultaneous use with thyroid hormones, there have been reports of confusion, irritability and sleep disturbance.

According to a published study of patients with recurrent venous thrombosis piracetam at a dose of 9.6 g / day increases the effectiveness of indirect anticoagulants (there was a more pronounced decrease in platelet aggregation, fibrinogen concentration, von Willebrand factors, blood and plasma viscosity compared with the use of only indirect anticoagulants).

Piracetam does not inhibit cytochrome P450 isoenzymes. Metabolic interaction with other drugs is unlikely.

Reception of piracetam at a dose of 20 g / day for 4 weeks did not change C max in serum and AUC of antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproate).

Co-administration with alcohol did not affect the concentration of piracetam in serum; the concentration of ethanol in the blood serum did not change when taking 1.6 g of piracetam.

Side effects

From the nervous system: motor disinhibition (1.72%), irritability (1.13%), drowsiness (0.96%), depression (0.83%), asthenia (0.23%); in isolated cases - dizziness, headaches, ataxia, imbalance, exacerbation of the course of epilepsy, insomnia, confusion, agitation, anxiety, hallucinations, increased sexuality. In post-marketing practice, the following side effects were observed, the frequency of which has not been established (due to insufficient data): headache, insomnia, agitation, imbalance, ataxia, exacerbation of epilepsy, anxiety, hallucinations, confusion.

From the side digestive system: nausea, vomiting, diarrhea, abdominal pain (including gastralgia).

From the side of metabolism: weight gain (1.29%).

On the part of the organ of hearing and balance: vertigo.

From the side skin: dermatitis, itching, urticaria.

Allergic reactions: angioedema, hypersensitivity, anaphylactic reactions.

Others: in rare cases- pain at the injection site, thrombophlebitis, hyperthermia, arterial hypotension(with a / in the introduction).

In most cases, regression can be achieved similar symptoms by lowering the dose of the drug.

Indications

adults

• symptomatic treatment of psycho-organic syndrome, in particular in elderly patients, accompanied by memory loss, dizziness, reduced concentration attention and decreased activity, mood changes, conduct disorder, gait disturbance (these symptoms may be early signs age-related diseases such as Alzheimer's disease and senile dementia of the Alzheimer's type);
• treatment of dizziness and related imbalance, with the exception of vasomotor and psychogenic dizziness;
• treatment of cortical myoclonus (as monotherapy or as part of complex therapy);

• treatment of dyslexia (as part of complex therapy);
• prevention of sickle cell vaso-occlusive crisis.

Contraindications

• psychomotor agitation at the time of drug administration;
• chorea of ​​Huntington;
• acute disorder cerebral circulation(hemorrhagic stroke);
• the end stage of chronic renal failure (with CC< 20 мл/мин);
• childhood up to 1 year (for oral solution);
• children's age up to 3 years (for tablets);
• hypersensitivity to the components of the drug;
• hypersensitivity to pyrrolidone derivatives.

With caution, the drug should be used in violation of hemostasis, extensive surgical interventions, severe bleeding, in chronic renal failure (CC 20-80 ml / min).

Application features

Use during pregnancy and lactation

Adequate and strictly controlled studies of the safety of the use of Nootropil during pregnancy have not been conducted. Controlled studies of the use of the drug during pregnancy have not been conducted.

Piracetam crosses the placental barrier. The concentration of the drug in newborns reaches 70-90% of its concentration in the blood of the mother. Nootropil ® should not be used during pregnancy.

Piracetam is released from breast milk. When prescribing the drug during lactation, you should refrain from breastfeeding.

Application for violations of liver function

Application for violations of kidney function

Patients with renal insufficiency require dose adjustment of the drug in accordance with the following scheme.

Use in children

Contraindication: children under 1 year of age (for oral solution); children's age up to 3 years (for tablets).

special instructions

Due to the effect of piracetam on platelet aggregation, the drug should be administered with caution to patients with impaired hemostasis, during major surgical interventions, or to patients with symptoms of severe bleeding.

In the treatment of cortical myoclonus, abrupt interruption of treatment should be avoided, because. this may cause seizures to recur.

In the treatment of sickle cell anemia, a dose of less than 160 mg / kg or irregular intake of the drug can cause an exacerbation of the disease.

With long-term therapy in elderly patients, regular monitoring of renal function is recommended, if necessary, dose adjustment is carried out depending on the results of the CC study.

When treating patients on a hyposodium diet, it is recommended to take into account that the oral solution of piracetam at a dose of 24 g contains 80.5 mg of sodium.

Piracetam penetrates through the filter membranes of hemodialysis machines.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care should be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

In this article, you can read the instructions for use medicinal product Nootropil. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of doctors of specialists on the use of Nootropil in their practice. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Nootropil in the presence of available structural analogues. Use to treat the effects of stroke and brain disorders in adults, children, as well as during pregnancy and lactation.

Nootropil - nootropic drug, a cyclic derivative of gamma-aminobutyric acid (GABA).

Directly affects the central nervous system, improving cognitive (cognitive) processes, such as learning ability, memory, attention, and mental performance. Nootropil has an effect on the central nervous system different ways: changes the speed of propagation of excitation in the brain, improves metabolic processes in nerve cells, improves microcirculation, affecting the rheological characteristics of the blood and without causing a vasodilating effect.

Improves connections between the hemispheres of the brain and synaptic conduction in neocortical structures, increases mental performance, improves cerebral blood flow.

Piracetam (active ingredient of the drug Nootropil) inhibits platelet aggregation and restores the elasticity of the erythrocyte membrane, reduces the adhesion of erythrocytes. At a dose of 9.6 g, it reduces the level of fibrinogen and von Willebrand factors by 30-40% and prolongs bleeding time. Piracetam has a protective and restorative effect in case of impaired brain function due to hypoxia and intoxication.

Nootropil reduces the severity and duration of vestibular nystagmus.

Compound

Piracetam + excipients.

Pharmacokinetics

After taking the drug inside Nootropil is rapidly and almost completely absorbed from the gastrointestinal tract. The bioavailability of the drug is approximately 100%. Does not bind to plasma proteins. In animal studies, piracetam selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia. Not metabolized in the body. Penetrates through the blood-brain and placental barrier. 80-100% of piracetam is excreted by the kidneys unchanged by renal filtration.

Indications

• symptomatic treatment of psychoorganic syndrome, in particular in elderly patients with memory loss, dizziness, decreased concentration and general activity, mood changes, behavioral disorders, gait disturbance, as well as in patients with Alzheimer's disease and senile dementia of the Alzheimer type;
• treatment of consequences of ischemic stroke, such as speech disorders, emotional sphere, to increase motor and mental activity;
• chronic alcoholism - for the treatment of psychoorganic and withdrawal syndromes;
• coma (and during the recovery period), incl. after trauma and intoxication of the brain;
• treatment of dizziness of vascular origin;
• as part of the complex therapy of low learning ability in children with psychoorganic syndrome;
• for the treatment of cortical myoclonus as mono- or complex therapy;
• sickle cell anemia (as part of complex therapy).

Release forms

Film-coated tablets 800 mg and 1200 mg.

Capsules 400 mg.

Oral solution 200 mg/ml.

Solution for intravenous and intramuscular administration (injections in ampoules for injection).

Instructions for use and dosage

Assign inside and parenterally. Daily dose- 30-160 mg/kg.

Parenterally prescribed in case of impossibility of oral administration, in the same daily dose.

Inside taken during a meal or on an empty stomach; tablets and capsules should be taken with liquid (water, juice). Multiplicity of reception - 2-4 times a day.

At symptomatic treatment chronic psychoorganic syndrome, depending on the severity of symptoms, 1.2-2.4 g per day is prescribed, and during the first week - 4.8 g per day.

In the treatment of the consequences of a stroke ( chronic stage) appoint 4.8 g per day.

In the treatment of coma, as well as difficulties in perception in persons with brain injuries, the initial dose is 9-12 g per day, the maintenance dose is 2.4 g per day. Treatment continues for at least 3 weeks.

With alcohol withdrawal syndrome - 12 g per day. Maintenance dose 2.4 g per day.

Treatment of dizziness and related balance disorders - 2.4-4.8 g per day.

To correct learning disabilities, children are prescribed 3.3 g per day - 8 ml of a 20% oral solution 2 times a day. Treatment continues throughout the school year.

With cortical myoclonus, treatment begins with 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day until a maximum dose of 24 g per day is reached. Treatment continues throughout the entire period of the disease. Every 6 months, attempts are made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g every 2 days. If there is no effect or a slight therapeutic effect, treatment is stopped.

In sickle cell anemia, the daily prophylactic dose is 160 mg/kg of body weight, divided into 4 equal doses.

Side effect

• nervousness;
• drowsiness;
• depression;
• dizziness;
• headache;
• imbalance;
• insomnia;
• excitation;
• anxiety;
• hallucinations;
• increased sexuality;
• an increase in body weight (more often occurs in elderly patients receiving the drug in doses of more than 2.4 g per day);
• nausea, vomiting;
• diarrhea;
• stomach ache;
• dermatitis;
• rashes;
• edema;
• asthenia.

Contraindications

• acute violation of cerebral circulation (hemorrhagic stroke);
• end-stage renal disease (with CC<20 мл/мин);
• children's age up to 1 year (for oral solution);
• children's age up to 3 years (for tablets and capsules);
• hypersensitivity to the components of the drug.

Use during pregnancy and lactation

Adequate and strictly controlled studies of the safety of the use of Nootropil during pregnancy have not been conducted. Do not prescribe the drug during pregnancy, except in cases of emergency.

Piracetam crosses the placental barrier and is excreted in breast milk. The concentration of piracetam in newborns reaches 70-90% of its concentration in the blood of the mother. If necessary, the use of the drug during lactation should refrain from breastfeeding.

In experimental studies on animals, there was no damaging effect on the embryo and its development, incl. in the postnatal period, as well as changes in the course of pregnancy and childbirth.

Use in children

Contraindicated in children under 1 year of age in the form of an oral solution and in children under 3 years of age in the form of tablets and capsules.

special instructions

In connection with the effect of piracetam on platelet aggregation, it is recommended to prescribe the drug with caution in patients with impaired hemostasis, during major surgical operations or in patients with symptoms of severe bleeding. In the treatment of patients with cortical myoclonus, an abrupt interruption of treatment should be avoided, which may cause the resumption of attacks.

With long-term therapy in elderly patients, regular monitoring of renal function is recommended, if necessary, dose adjustment is carried out depending on the results of the study of creatinine clearance.

Influence on the ability to drive vehicles and control mechanisms

Taking into account possible side effects, care should be taken when working with machinery and driving a car.

drug interaction

There was no interaction of Nootropil with clonazepam, phenytoin, phenobarbital, sodium valproate.

Piracetam in high doses (9.6 g per day) increased the effectiveness of acenocoumarol in patients with venous thrombosis: there was a greater decrease in the level of platelet aggregation, fibrinogen levels, von Willebrand factors, blood and plasma viscosity than with the appointment of acenocoumarol alone.

The possibility of changing the pharmacodynamics of piracetam under the influence of other drugs is low, because 90% of its dose is excreted unchanged in the urine.

When taking piracetam at a dose of 20 mg per day, Cmax in blood plasma and the nature of the pharmacokinetic curve of anticonvulsants (carbamazepine, phenytoin, phenobarbital, valproic acid) do not change in patients with epilepsy receiving constant doses of these drugs.

When taking Nootropil at a dose of 1.6 g with alcohol, the serum concentrations of piracetam and ethanol (alcohol) did not change. Used to treat alcohol withdrawal syndrome.

Analogues of the drug Nootropil

Structural analogues for the active substance:

• Lucetam;
• Memotropil;
• Nootobril;
• Noocetam;
• Pirabene;
• Pyramem;
• Pyratropil;
• Piracetam;
• stamin;
• Cerebril;
• Escotropil.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Instructions for use describe a fairly serious number of diseases that this remedy resists. It must also be taken in chronic alcoholism, Alzheimer's disease, balance disorders, psychoorganic syndrome, and even in a coma. The dosage of admission in the instructions for use is from 30 to 160 mg per kg of body weight per day. It can be taken orally or parenterally.

Composition of nootropil

The composition of the drug depends on the form of release. However, the active substance in any case remains piracetam. Additional components in these tablets or capsules are macrogol 6000, aerosil P972, lactose and magnesium stearate.

Indications for the use of nootropil

Below are all the main indications for this drug:

• myoclonus;
• anemia;
• headache, dizziness, balance problems;
• reduced learning in children;
• alcoholism;
• to improve motor and psychoactivity;
• reduced memory and ability to concentrate;
• coma.

Contraindications

In addition to indications, there are a number of contraindications in the instructions:

• kidney failure;
• children under 1 year of age;
• hypersensitivity to components;
• stroke.

Doctors prescribe this remedy to pregnant women only in vital situations.

Nootropil tablets instructions for use tablets

One tablet can be 0.8 or 1.2 g. For action and proper effect in case of memory impairment, the nootropic drug is taken in an amount of 4.8 g per day. The dosage is divided into 2-3 doses. After the first week, you can gradually reduce the dosage to 1.2 g / day.

With cortical myoclonus, the first three days, the dosage is 2.4 g, the next - 1.2 g.

In many cases, the dosage is calculated according to the patient's weight - from 30 mg to 160 mg per 1 kg of live weight.

Syrup for children nootropil instructions for use

For children, Nootropil syrup is recommended to be taken to improve concentration and memory. In the reviews, you can find that children have problems with this called learning disabilities. You can increase it by taking 1.6 g twice a day. As practice shows, this dosage improves the performance of children in school.

Nootropil 800 instructions for use

Since the dosage in this form of release is 800 mg, the distribution for various diseases is as follows:

• with dizziness, 1 tablet 3 times a day;
• with psychoorganic syndrome - 1-2 tablets 3 r / day.
• at the beginning of cortical myoclonus - 2-3 tablets 3 times a day;
• for the prevention of a crisis - 160 mg / 1 kg of body weight, divided into 4 doses.

Nootropil injections instructions for use

According to the instructions, indications for intravenous or intramuscular use are relevant when the oral method is not possible. The dose per injection should not exceed 3 g. The dosage in ampoules of 2.4-4.8 g is most often distributed per day. The drug is preliminarily diluted in solutions.

Analogues

A fairly large list of drugs belongs to analogues or substitutes. The list of analogues includes lucetam, biotropil, piracetam and phenotropil.

Nootropil or piracetam which is better?

These drugs are analogues. Both of them have piracetam as the active ingredient. However, unlike analogues, the Piracetam drug is manufactured by a domestic pharmaceutical company, therefore its price is 2-3 times lower.

Phenotropil or nootropil which is better?

Between these analogues, on the contrary, Phenotropil is more expensive. The composition of the funds is approximately the same and the action too. Although in terms of price / quality ratio, according to the reviews, it is Nootropil that wins. In addition, Phenotropil has more side effects.

Contraindications for use and side effects

There are not as many contraindications as there are indications. These include only kidney failure, stroke and individual intolerance to the components. It is also prohibited for children under 1 g and pregnant women.
Side effects: diarrhea, nausea, vomiting, abdominal pain, weight gain, itching, swelling, rash, depression, nervousness, drowsiness.

Nootropil reviews of doctors

Sergey Pryanov, psychiatrist: Still, the effect is manifested in most patients. It is especially effective in the correction of asthenia and neurolepsy.

Price

30 tablets of 0.8 g can be purchased at a price of 250 to 300 rubles.