Diuretic drugs that inhibit the process of sodium reabsorption in the renal tubules. Contraindications to taking Hydrochlorothiazide. Visitor Report on Side Effects

Hypertension is dangerous because it does not always make itself felt clearly severe symptoms. A person may not take changes in his condition seriously enough, although increased pressure on the vascular walls is fraught with heart attacks and strokes. Therefore, at the first sign of illness, it is important to visit a doctor.

At initial stage hypertension is often prescribed hydrochlorothiazide. It is a thiazide diuretic medium duration action, which, in addition to a diuretic, also has a hypotensive effect. It is used as a first-line drug for a small level of pressure increase, when the possibilities to normalize it without the use of medicines have been exhausted. average price Hydrochlorothiazide - 70-80 rubles.

Release form and composition

Produced in tablets - 20 pieces per pack. The active substance is hydrochlorothiazide (25 or 100 mg per tablet).

medicinal properties

The diuretic effect appears after 2 hours, reaches its peak after 4 hours and lasts 12 hours. high blood pressure. It also reduces polyuria (excessive urine production) in diabetes insipidus. May reduce intraocular pressure in patients with glaucoma.

Indications

Doses and methods of application

The instructions for use of Hydrochlorothiazide say that the tablets are drunk before meals. Dosages are selected by the doctor, based on the specific case.

adults

Hypertension: 25-50 mg per day as a single dose (as part of monotherapy or together with other medications that lower blood pressure). Sometimes 12.5 mg is enough. You need to use the minimum effective dose selected by a doctor, but it should not be more than 100 mg per day.

It may be necessary to reduce the doses of other antihypertensive agents to prevent an excessive decrease in pressure. Hypotensive action occurs in 3-4 days, and the optimal effect should be expected 3-4 weeks. After the abolition of the remedy, the achieved effect lasts for 1 week.

Edema: 25-100 mg 1 time per day or every other day, then a decrease to 25-50 mg is acceptable. AT severe cases sometimes 200 mg per day is required.

PMS: 25 mg per day. Tablets are drunk before the onset of menstruation.

Diabetes insipidus: 50-150 mg per day, divided into several doses.

The dosage is determined based on the weight of the child. Usually this is a single dose of 1-2 mg per 1 kg or 30-60 mg per 1 sq. m of body surface per day. The dose for children under 2 years old per day is 12.5-37.5 mg, for children 2-12 years old - up to 100 mg.

Side effects

Gastrointestinal: pancreatitis, cholestatic jaundice, cholecystitis, weight loss, constipation or diarrhea.

Cardiovascular system and blood: arrhythmias, vasculitis, hypotension, extremely rarely - anemia, leukopenia.

Electrolyte imbalance: changes in sodium, magnesium, calcium and potassium levels, accompanied by convulsions, lethargy, cramps and muscle pain, slow thinking, lethargy, anxiety, thirst, arrhythmia, mood swings, confusion, nausea, vomiting; possible hypochloremic alkalosis with subsequent hepatic coma/encephalopathy.

Hypersensitivity reactions: purpura, photosensitivity, urticaria, anaphylactic shock.
CNS and sensory organs: blurry vision (normalized after discontinuation of the drug), paresthesia, headaches and dizziness.

There may also be malfunctions in the functioning of the kidneys and a decrease in potency.

Contraindications

During lactation and in the 1st trimester of pregnancy, the drug is not prescribed, in the 2nd and 3rd it is used with caution.

Interaction with other drugs

The diuretic effect of hydrochlorothiazide is enhanced when it is taken with drugs that intensely bind proteins. These are non-steroidal anti-inflammatory drugs, Clofibrate, indirect anticoagulants.

The hypotensive effect is enhanced when combined with beta-blockers, barbiturates, tricyclic antidepressants, phenothiazines, ethyl alcohol.

Under the action of the drug, the neurotoxicity of salicylates increases, the excretion of quinidine and the effectiveness of birth control pills. It also weakens oral medication for hypoglycemia, epinephrine and gout medications.

In combination with hydrochlorothiazide, an increase in side effects cardiac glycosides, neuro- and cardiotoxic effects of Li+ preparations and peripheral muscle relaxants.

The combination with Methyldopa is fraught with hemolysis.

special instructions

At first, you can not drive a car and do work that requires high concentration attention.
With prolonged use of Hydrochlorothiazide, it is necessary to monitor the violations of the water and electrolyte balance, especially with a predisposition.

Risk factors are liver failure, heart and vascular disease, thirst, dry mouth, severe vomiting, drowsiness, anxiety, fatigue, lethargy, hypotension, muscle cramps, pain and weakness, tachycardia, oliguria, problems with the gastrointestinal tract.

To avoid hypokalemia, along with hydrochlorothiazide, you need to take potassium supplements or eat vegetables and fruits rich in this element. This is especially important with long-term treatment and the simultaneous use of digitalis glycosides or corticosteroids.

Hydrochlorothiazide may cause impaired glucose tolerance. With long-term treatment of latent or manifesting diabetes mellitus, it is important to regularly check carbohydrate metabolism.

When taking thiazides, the excretion of magnesium in the urine increases, which is fraught with hypomagnesemia. With a decrease in kidney function, creatinine clearance should be observed. The drug can provoke azotemia. If oliguria occurs, it is recommended to stop treatment.

Analogues

If hydrochlorothiazide is not suitable, you can choose similar preparations with the same active ingredient:

There are also a number combined drugs. The combination + hydrochlorothiazide is included in Blocktran GT, Gizortana, Lozap plus, Losartan-N Richter.

Valsartan and hydrochlorothiazide are the active ingredients of Valsacor, Vanatex Combi, Co-Diovan, Duopress.
In combination with dihydralazine, hydrochlorothiaz is included in Adelfan-Ezidrex.

The combination of hydrochlorothiazide + is present in Berlipril plus, Prilenap, Enam N, Co-renitek, Renipril GT, Enalapril N, Enafarm-N.

Active substances and hydrochlorothiazide are included in Coaprovel and Ibertan Plus.

Storage

A dark, dry, inaccessible place for children with a temperature of no more than +25 degrees.

Synonyms: Hypothiazid (B), Nephrix (R), Dichlotride Dihydran, Dihydrochlorthiazid, Disalunil (G), Esidrex, Esidrix, Hidrosaluretil, Hydrex, Hydril, Hydrochlorothiazidum, Hydrochlorthiazide, Hydro-Diuril, Hydro-Saluric, Hydrothide, Hypothiazid (B) , Nefrix (P), Novodiurex, Oretic, Panurin, Unazid (U), Urodiazin (G), Vetidrex, etc.
White or white with a yellowish tint crystalline powder. Let's very little dissolve in water, a little - in alcohol, it is easy in solutions of caustic alkalis.

Dichlothiazide is a highly active diuretic oral administration. By chemical structure refers to the group of benzothiadiazine derivatives containing a sulfonamide group in the C(7) position. The presence of this group makes dichlothiazide related to diacarb. However, dichlothiazide inhibits carbonic anhydrase much less than diacarb, and dichlothiazide is much more effective in diuretic action.

The first representative of diuretics (saluretics) of the benzothiadiazine group was chlorthiazide. Dichlothiazide differs from chlorothiazide in the absence of a double bond at position 3,4 of the thiadiazine nucleus. Compared to chlorthiazide, dichlothiazide is more effective and acts at much lower doses. Studies have shown that relatively small changes in the chlorothiazide molecule can lead to a significant change in activity. So, in even smaller doses than dichlothiazide, cyclomethiazide acts. The relative activity, based on the inverse ratio of doses that have the same diuretic effect, is approximately 1: 10: 1000 for chlorthiazide, dichlothiazide and cyclomethiazide.

The diuretic effect of dichlorothiazide, as well as other diuretics of the benzothiadiazine group, is due to a decrease in the reabsorption of sodium ions in the proximal (and partially in the distal) part of the convoluted tubules of the kidneys; reabsorption of potassium and bicarbonates is also inhibited, but to a lesser extent. In connection with a strong increase in natriuresis with a simultaneous increase in the excretion of chlorides, dichlothiazide is considered as an active saluretic agent; excretion of sodium and chlorine from the body occurs in equivalent amounts. The drug has a diuretic effect in both acidosis and alkalosis. diuretic effect on long-term use dichlothiazide is not reduced.

It should be pointed out that in case of diabetes insipidus, dichlothiazide, like other diuretics of the benzothiadiazine series, has a "paradoxical" effect, causing a decrease in polyuria. There is also a decrease in thirst. Significantly reduced elevated osmotic pressure blood plasma that accompanies this disease. The mechanism of this effect is not clear enough. By modern ideas, it is partly associated with an improvement in the concentrating ability of the kidneys ( peripheral action) and inhibition of the activity of the center of thirst (central action).

Dichlothiazide also has a hypotensive effect, which is usually observed with high blood pressure. This action may be partly due to increased excretion of salts and water from the body, which leads to some decrease in the volume of circulating plasma and extracellular fluid. There are, however, data showing that the hypotensive effect is not directly related to increased diuresis: benzothiadiazine derivatives have been obtained that are devoid of a diuretic effect and have a hypotensive effect. In addition, in the absence of congestion in hypertensive patients, the administration of dichlothiazide causes a decrease in blood pressure, which is not accompanied by an increase in diuresis. Experimental studies give reason to believe that under the influence of benzothiadiazine derivatives, a change occurs metabolic processes in cell membranes arterioles and, in particular, the extraction of Na ions from them, which leads to a decrease in swelling and a decrease in peripheral vascular resistance. It is possible that, in this case, it is not the absolute decrease in the content of Na+ in the walls of the vessels that plays a role, but a change in the ratio between its intra- and extracellular content.

Under the influence of dichlothiazide, reactivity changes vascular system, pressor reactions to vasoconstrictor substances (adrenaline, etc.) decrease and depressor reaction to ganglioblocking agents increases.

Apply hypothiazide as a diuretic (saluretic) agent for congestion in the small and big circle circulation associated with cardiovascular insufficiency; cirrhosis of the liver with symptoms of portal hypertension; nephrosis and nephritis (with the exception of severe progressive forms with a decrease in the rate glomerular filtration); toxicosis of pregnancy (nephropathy, edema, eclampsia); premenstrual states, accompanied by congestion.

Dichlothiazide prevents the retention of sodium and water ions in the body that accompanies the use of mineralocorticoids; it is therefore also prescribed for edema caused by the hormones of the adrenal cortex and adrenocorticotropic hormone of the pituitary gland. The use of dichlothiazide prevents or reduces the increase in blood pressure caused by these drugs.

The diuretic effect after taking dichlothiazide develops rapidly (during the first 1-2 hours) and lasts up to 10-12 hours or more after a single dose.

Dichlothiazide is also a valuable agent in the treatment hypertension. The use of the drug is especially recommended for hypertension, accompanied by circulatory failure. Since dichlothiazide potentiates the action of reserpine, apressin, octadine and others antihypertensive drugs, then it is advisable to prescribe it in combination with these drugs, especially in patients with high blood pressure. blood pressure. Combined treatment can be effective and malignant course hypertension (N. A. Ratner and others).

Doses of antihypertensive drugs combined application with dichlothiazide can be reduced (2-3 times).

The hypotensive effect of dichlothiazide is somewhat enhanced by observing a salt-free diet, however, it is not recommended to severely limit the intake of salt with the diet.

Dichlothiazide in some cases lowers intraocular pressure and normalizes ophthalmotonus in glaucoma (mainly in subcompensated forms). The effect occurs 24-48 hours after taking the drug. Against the background of the use of miotics normal level intraocular pressure lasts from 1 to 6 days, then the pressure rises again and decreases after the next intake of dichlothiazide.

Assign dichlothiazide inside in tablets. Doses are selected individually depending on the severity of the disease and the effect.

A single dose for different patients when prescribed as a diuretic can range from 0.025 g (25 mg) to 0.2 g (200 mg).

In mild cases, appoint 0.025-0.05 g (1-2 tablets) per day, in more severe cases, 0.1 g per day. Take once (in the morning) or in 2 doses (in the first half of the day). Sometimes prescribed up to 0.2 g per day. Increasing the dose above 0.2 g is impractical, since a further increase in diuresis usually does not occur. The elderly with cerebral forms hypertensive disease, the drug is prescribed in smaller doses (0.0125 g 1-2 times a day) (N. B. Mankovsky and others).

The drug can be prescribed for 3-5-7 days in a row, then take a break for 3-4 days and continue taking the drug again; in milder cases, take breaks after every 1-2 days of admission. The duration of the course and the total duration of treatment depend on the nature and severity of the disease, the effect obtained, and tolerance. Treatment, especially in the early days, should be carried out under medical supervision.

In case of hypertension, 0.025-0.05 g (1-2 tablets) per day is prescribed, usually together with antihypertensive drugs.

Patients with glaucoma are prescribed 0.025 g per day.

Dichlothiazide is usually well tolerated, however, with prolonged use, hypokalemia (often moderate) and hypochloremic alkalosis may develop. Hypokalemia often develops in patients with cirrhosis of the liver and nephrosis. Hypochloremic alkalosis is more common with a low-salt diet or loss of chlorides due to vomiting or diarrhea. Treatment with dichlothiazide is recommended against the background of a diet rich in potassium salts. If symptoms of hypokalemia appear, potassium salts should be prescribed (potassium chloride solution at the rate of 2 g of the drug per day). Potassium salts are also recommended for patients receiving digitalis and corticosteroids simultaneously with dichlothiazide. With hypochloremic alkalosis, sodium chloride is prescribed.

When using dichlothiazide, there may be an exacerbation of latent gout and diabetes mellitus.

When applied large doses dichlothiazide sometimes possible weakness, nausea, vomiting, diarrhea; these phenomena disappear with a decrease in dose or a short break in taking the drug. AT rare cases possible dermatitis.

When combined with ganglioblocking drugs, the possibility of increased postural hypotension should be considered.

Dichlothiazide should not be given to patients with severe renal insufficiency. In less severe cases, it is necessary to monitor the balance of electrolytes and the content of non-protein nitrogen.

Release form: tablets of 0.025 g (25 mg).

Storage: list B. In a dry place.

In hypertension, diuretics are prescribed to lower blood pressure, in particular Hydrochlorothiazide, the instructions for use of which indicate that this is a very effective diuretic drug. Application of the drug contributes to the stabilization blood pressure, removal of excess fluid, salts from tissues, improvement general condition well-being, as well as a significant improvement in the quality of life.

The cost of the drug Hydrochlorothiazide is low, due to which opportunity to acquire Hydrochlorothiazide is available in all categories of patients. The drug is dispensed exclusively by prescription for Latin from the doctor. Self-medication - uncontrolled intake of Hydrochlorothiazide is fraught with undesirable consequences.

Let's find out the indications for taking the drug, the mechanism of action, the price of the drug, analogues and reviews.

Composition and form of release of Hydrochlorothiazide

In Latin, the trade name of Hydrochlorothiazide is Hydrochlorthiazidum.

The active ingredient of the drug - hydrochlorothiazide or hydrochlorothiazide - in 1 tablet 25 or 100 mg.

Also, the tool is endowed with such additional components:

1. lactose monohydrate.
2. Povidone.
3. Cellulose.
4. Corn starch.
5. Mg stearate.

Hydrochlorothiazide release form - tablets white color, flat-cylindrical shape. Tablets are packaged in blisters - two per pack.

Many people are interested in the question - what are Hydrochlorothiazide tablets for, at what pressure can they be drunk. medicine is given to people suffering from high blood pressure.

This remedy is from pharmacological group thiazide diuretics. The use of Hydrochlorothiazide contributes to:

• Violation of the absorption of Na ions, water, chlorine.
• Removal enhancement ions K, Mg.
• Downgrade HELL.
• Minimization of edema.

Diuretic effect Hydrochlorothiazide is caused by the removal of excess water from the body.

Maximum therapeutic effect the drug develops after two hours after taking the pill. The duration of exposure to Hydrochlorothiazide is 12 hours.

Related video:

Indications for the use of the drug

Hydrochlorothiazide, according to the instructions for use, is prescribed to people suffering from:

1. Hypertension.
2. Nephrotic edema.
3. Heart failure, accompanied by severe edema.
4. Subcompensated forms of glaucoma.
5. Acute glomerulonephritis.
6. Cirrhosis of the liver.
7. Chronic renal failure.
8. Not diabetes.
9. Edema of various genesis.

State photos:

Hypertension

Nephrotic edema

Heart failure

Glaucoma

Glomerulonephritis

diabetes insipidus

Use during gestation and lactation

Hydrochlorothiazide not assigned during pregnancy (in the 1st trimester). The ban is conditioned for application possible violation medication of the process of formation of organs, systems of the fetus.

The use of the drug during breastfeeding is prohibited. This is due to the ability active ingredient penetrate breast milk and, consequently, into the body of the fetus.

In urgent need the use of hydrochlorothiazide, the doctor will recommend stopping breastfeeding.

Contraindications for taking Hydrochlorothiazide

This diuretic drug, like any other medication, along with indications for use has a number contraindications. Before you start taking the pills you need to make sure in the absence of contraindications. Ignoring this recommendation is fraught with the appearance adverse reactions from the side various organs, systems.

It is forbidden to take composition also for people suffering from such pathological conditions, diseases:

• Gout.
• Addison's disease.
• Anuria.
• Diabetes mellitus.
• Refractory hypokalemia, hyponatremia, hypercalcemia.
• Rare hereditary diseases: lactose intolerance, lactase deficiency.

Photo gallery:

Gout

Addison's disease

Anuria

Diabetes

Apart from absolute contraindications to the use of medication there are also relative. Hydrochlorothiazide is not recommended for:

1. IHD (ischemic heart disease).
2. Progressive pathologies of the liver.

Also, the use of the drug is prescribed with caution. elderly people.

Side effects of the drug

When used appropriately, hydrochlorothiazide will bring the body exceptional benefit will help in eliminating unpleasant symptoms, lowering blood pressure, improving the general condition, well-being.

Side effects after the use of the drug, they rarely occur and usually pass quickly. Incorrect use of Hydrochlorothiazide may cause unwanted reactions.

Table of side effects

Instructions for use of the drug - method and dosage

Pick up correct dosage tablets can only be taken by a doctor and solely taking into account the age of the person, the pathology and its severity, and the general state of health. Taking medication without a doctor's prescription not recommended. Doses and method of taking a diuretic drug indicated in the table.

The medicine is taken orally, after a meal:

Medicine overdose

In case of improper use of the drug Hydrochlorothiazide - excess doses, frequency of use possible appearanceoverdose symptoms.

The abuse of the composition is associated with the risk of:

• Tachycardia.
• Arrhythmias.
• Drowsiness.
• Xerostomia.
• Pressure drops.
• Adynamia.
• Paralysis.
• Comas.

There is no specific antidote. In case of an overdose, symptomatic therapy, consisting in gastric lavage, the use of adsorbents, infusion of electrolyte solutions.

drug interaction

The use of certain drugs together with hydrochlorothiazide is incompatible, may be accompanied a decrease or increase in the action of one of the means, as well as lead to a significant deterioration in well-being.

The use of Hydrochlorothiazide with:

1. Indirect anticoagulants, non-steroidal anti-inflammatory drugs, Clofibrate fraught with amplification diuretic effect of the first.
2. Beta-blockers, tricyclic antidepressants, Diazepam is fraught with increased hypotensive effect first.
3. Indomethacin is fraught decreased hypotensive effect first.
4. fraught with cardiac glycosides increased risk of toxicity of the second.
5. Corticosteroid hormones fraught with hypokalemia.

special instructions

When using a diluted drug need to follow for indicators water-salt balance, especially if you need to take a long course.

People suffering from malfunctions in the functioning of the urinary system need to be controlled daily diuresis .

Application of Hydrochlorothiazide associated with a decrease concentration and responsiveness. While taking medication should refrain from driving a car, as well as managing complex mechanisms.

Shelf life and storage conditions of the medicine

The medicine can be stored and used for two years. The drug should be stored in a dark place temperature regime at 20 degrees. The place where the drug is stored should be inaccessible to children.

The price of the drug in pharmacies

The average price of a drug in a dosage of 25 mg. No. 20 - 45 rubles, and in a dosage of 100 mg. - 60 rubles.

Terms of dispensing from pharmacies

You can buy Hydrochlorothiazide in a pharmacy in any dose and quantity only in the presence of doctor's prescription.

If for some reason taking Hydochlorothiazide is not possible, the doctor will replace it with an analogue:

• dichlothiazide.
• Hypothiazide.
• Hydrochlorothiazide-ATS.
• Hydrochlorothiazide-Werte.
• Indapamide.
• Hydrosalurethil.

The analogues of the drug dichlothiazide are presented, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more of the same active substances. When choosing synonyms, consider not only their cost, but also the country of origin and the reputation of the manufacturer.

Description of the drug

List of analogues

Note! The list contains synonyms Dichlothiazide, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

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Official instructions for use

HYDROCHLOROTHIAZIDE

international generic name: Hydrochlorothiazide* (Hydrochlorothiazide*)

Dosage form: tablets
Compound
1 tablet contains:
active substance: hydrochlorothiazide (in terms of 100% substance) - 25 mg or 100 mg;
Excipients: microcrystalline cellulose, milk sugar (lactose), potato starch, magnesium stearate.
Description
White or white with a yellowish tint, flat-cylindrical tablets with a bevel for a dosage of 25 mg, with a bevel and a line for a dosage of 100 mg.
Pharmacotherapeutic group: diuretic
ATX code: [C03AA03]

Pharmacological properties

Indications for use

Analogues (generics, synonyms)

Vetidrex, Hydrex, Hydril, Hydro-Diurivas, Hydrodiuril, Hydro-Saluric, Hydrosaluretal, Hydrothiazide, Hydrotide, Hydrochlorothiazide, Hydrochlorothiazide, Hydrochlorothiazil, Hypothiazide, Divaugan, Dihydran, Dihydrochlorothiazide, Dihydrochlorothiazide, Dihydrochloruride, Disalunil, Disalunil, Di, Dichlorothiazide, Doclicid, Idrodiovis, Idroniagar, Idrorenil, Idrochlorazide, Neo-Diuresal, Neo-Mincil, Neo-Sularetik, Neotride, Neoflumen, Neo-Chloruril, Nefrix, Novodiurex, Oretic, Panurin, Udor, Unazid, Urodiazine, Urodiacin, Urozil, Ehydride novum , Ezidrex, Ezidrix, Ezodrin,

Recipe

Rp: Dichlotiazidi 0.025
D.t. d. No. 20 in tab.
S. 1 tablet 1 time per day, in the morning.

pharmachologic effect

Medium strength thiazide diuretic. Reduces the reabsorption of Na + at the level of the cortical segment of the loop of Henle, without affecting its section passing into medulla kidneys, which determines a weaker diuretic effect in comparison with furosemide.

It blocks carbonic anhydrase in the proximal convoluted tubules, increases the excretion of K + in the urine (in the distal tubules Na + is exchanged for K +), bicarbonates and phosphates. It practically does not affect CBS (Na + is excreted either together with Cl- or with bicarbonate, therefore, with alkalosis, the excretion of bicarbonates increases, with acidosis - chlorides).

Increases excretion of Mg2+; delays Ca2+ ions in the body and excretion of urates. The diuretic effect develops after 1-2 hours, reaches a maximum after 4 hours, lasts 10-12 hours. The action decreases with a decrease in the glomerular filtration rate and stops when it is less than 30 ml / min. In patients with diabetes insipidus, it has an antidiuretic effect (reduces the volume of urine and increases its concentration). Lowers blood pressure by reducing BCC, changes in reactivity vascular wall, reducing the pressor effect of vasoconstrictor drugs (epinephrine, norepinephrine) and enhancing the depressor effect on the ganglia.

Mode of application

To reduce blood pressure: inside, 25-50 mg / day, while slight diuresis and natriuresis are noted only on the first day of admission (prescribed for a long time in combination with other antihypertensive drugs: vasodilators, ACE inhibitors, sympatholytics, beta-blockers).
When the dose is increased from 25 to 100 mg, a proportional increase in diuresis, natriuresis and a decrease in blood pressure are observed.
In a single dose of more than 100 mg - an increase in diuresis and a further decrease in blood pressure are insignificant, there is a disproportionately increasing loss of electrolytes, especially K + and Mg2 +. Increasing the dose over 200 mg is not advisable, because. diuresis does not increase.

In case of edematous syndrome (depending on the condition and reaction of the patient), it is prescribed in a daily dose of 25-100 mg, taken once (in the morning) or in 2 doses (in the first half of the day). Elderly people - 12.5 mg 1-2 times a day. Children aged 2 months to 14 years - 1 mg / kg / day. Maximum dose for children under the age of 6 months - 3.5 mg / kg / day, up to 2 years - 12.5-37.5 mg / day, 3-12 years old - 100 mg / day, divided into 2-3 doses.
After 3-5 days of treatment, it is recommended to take a break for 3-5 days.
As a maintenance therapy in the indicated dose, it is prescribed 2 times a week.
When using an intermittent course of treatment with admission after 1-3 days or within 2-3 days with a subsequent break, the decrease in effectiveness is less pronounced and side effects develop less frequently.
To reduce intraocular pressure, 25 mg is prescribed 1 time in 1-6 days; the effect occurs after 24-48 hours. In diabetes insipidus - 25 mg 1-2 times a day with a gradual increase in dose (daily dose - 100 mg) until therapeutic effect(reduction of thirst and polyuria), further dose reduction is possible.

Indications

Contraindications

severe liver failure, diabetic glomerulosclerosis, chronic diseases kidneys in the chronic stage kidney failure With hypoisostenuria and azotemia, oliguria and anuria in the first 3 months of pregnancy. Conditionally contraindicated in patients with gout and diabetes mellitus. It is necessary to appoint with caution with reduced tolerance to carbohydrates.

Side effects

Arterial hypertension, congestive heart failure, diabetes insipidus, liver cirrhosis with portal hypertension and edematous ascitic syndrome, glaucoma, nephritis, nephrosis; rarely - toxicosis of pregnant women.

Release form

Tablets of 0.025 and 0.1 g.

ATTENTION!

The information on the page you are viewing was created for informational purposes only and does not promote self-treatment in any way. The resource is designed to familiarize healthcare professionals with additional information about certain medicines, thereby increasing the level of their professionalism. The use of the drug Dichlothiazide" in without fail provides a consultation with a specialist, as well as his recommendations on the method of application and dosage of the medicine you have chosen.