What is novocaine for an injection in ampoules. Side effects of Novocain. Indications for use

NOVOCAINE Novocaine

Active substance

›› Procaine* (Procaine*)

Latin name

Pharmacological group: Local anesthetics

Nosological classification (ICD-10)

Composition and form of release

1 ml solution for injection contains procaine hydrochloride 5 mg; in 5 ml ampoules, cardboard box 10 pieces.

pharmachologic effect

pharmachologic effect- local anesthetic. Blocks the occurrence of an impulse and its conduction along the nerve fiber - especially the afferent one.

Indications

Infiltration, conduction, epidural and spinal anesthesia; vagosympathetic and pararenal blockade; pain syndrome in peptic ulcer stomach and duodenum, hemorrhoids, nausea.

Contraindications

Hypersensitivity.

Side effects

Dizziness, weakness, hypotension, allergic reactions.

Dosage and administration

V / m - 5-10 ml of a 1-2% solution 3 times a week for a month, after which a 10-day break is taken; for infiltration anesthesia apply 0.25-0.5% solutions, for conductor - 2% solution.
Inside - 1/2 tsp (for pain).

Best before date

Storage conditions

List B.: In a place protected from light, at a temperature not exceeding 30 ° C.

* * *

NOVOCAIN (Novocainum). b-Diethylaminoethyl ester of para-aminobenzoic acid hydrochloride. Synonyms: Aethocain, Allocaine, Ambocain, Aminocaine, Anesthocaine, Atoxicain, Cerocain, Chemocain, Citocain, Ethocaine, Genocaine, Herocaine, Isocain, Jenacain, Marecaine, Minocain, Naucain, Neocaine, Pancain, Paracaine, Planocaine, Polocainum, Procaine, Procaini hydrochloridum , Procaine hydrochloride, Protocaine, Sevicaine, Syncaine, Syntocain, Topocaine, etc. Colorless crystals or odorless white crystalline powder. Let's very easily dissolve in water (1:1), we will easily dissolve in alcohol (1:8). Aqueous solutions sterilized at + 100 C for 30 minutes. Solutions of novocaine are easily hydrolyzed into alkaline environment. To stabilize, add 0.1 n. hydrochloric acid solution to pH 3.8 - 4.5. Novocaine was synthesized in 1905. long time he was the main local anesthetic used in surgical practice. Compared to modern local anesthetics (lidocaine, bupivacaine, etc.), it has less strong anesthetic activity. However, due to the relatively low toxicity, large therapeutic breadth and additional valuable pharmacological properties allowing it to be used in various fields medicine, he still has wide application. Unlike cocaine, novocaine does not cause addiction phenomena. In addition to the local anesthetic effect, novocaine, when absorbed and directly injected into the bloodstream, has overall influence on the body: reduces the formation of acetylcholine and lowers the excitability of peripheral cholinergic systems, has a blocking effect on autonomic ganglia, reduces spasms smooth muscle, lowers the excitability of the heart muscle and motor cortex zones big brain. In the body, novocaine hydrolyzes relatively quickly, forming para-aminobenzoic acid and diethylaminoethanol. Breakdown products of novocaine - pharmacologically active substances. para-aminobenzoic acid (vitamin H 1) is integral part molecules folic acid; it is also included in bound state into other compounds found in plant and animal tissues. Para-aminobenzoic acid is a "growth factor" for bacteria. By chemical structure it is similar to part of the sulfonamide molecule; entering into competitive relations with the latter, para-aminobenzoic acid weakens them antibacterial action(see Sulfanilamide preparations). Novocaine, as a derivative of para-aminobenzoic acid, also has an antisulfanilamide effect. Diethylaminoethanol has moderate vasodilating properties. Novocain is widely used for local anesthesia- mainly for infiltration; for surface anesthesia it is of little use, as it slowly penetrates intact mucous membranes. Novocaine is widely prescribed for therapeutic blockades. For infiltration anesthesin, 0.25 - 0.5% solutions are used; for anesthesia according to the method of A.V. Vishnevsky (tight creeping infiltration) 0.125 - 0.25% solutions; for conduction anesthesia - 1 - 2% solutions; for epidural - 2% solution (20-25 ml). Sometimes novocaine is also prescribed for intraosseous anesthesia. For anesthesia of the mucous membranes, novocaine is sometimes used in otorhinolaryngology. To obtain a surface anesthetic effect, 10-20% solutions are required. With local anesthesia, the concentration of novocaine solutions and their amount depend on the nature surgical intervention; the method of application, the condition and age of the patient, etc. It should be borne in mind that with the same total dose of the drug, the toxicity is higher, the more concentrated the solution used is. To reduce the absorption and lengthen the action of novocaine solutions during local anesthesia, a solution of adrenaline hydrochloride (0.1%) is usually added to them - 1 drop per 2-5-10 ml of novocaine solution, since novocaine, unlike cocaine, does not cause vasoconstriction. Novocaine is also recommended for the treatment various diseases. Novocaine blockade aims to weaken the reflex reactions that occur during the development pathological processes. With pararenal blockade (according to A.V. Vishnevsky), 50 - 80 ml of a 0.5% solution or 100 - 150 ml of a 0.25% novocaine solution are injected into the perirenal tissue, and with vagosympathetic blockade - 30 - 100 ml of 0.25% solution. Solutions of novocaine are also used intravenously and orally (for hypertension, late toxicosis of pregnant women with hypertension, spasms blood vessels, phantom pains, peptic ulcer of the stomach and duodenum, nonspecific ulcerative colitis, itching, neurodermatitis, eczema, keratitis, iridocyclitis, glaucoma, etc.). From 1 to 10 - 15 ml of a 0.25 - 0.5% solution is injected into a vein. Enter slowly, preferably in isotonic solution sodium chloride. The number of injections (sometimes up to 10 - 20) depends on the severity of the disease and the effectiveness of the treatment. To relieve spasms peripheral vessels and improvement of microcirculation during frostbite (in the pre-reactive period), a mixture consisting of 10 ml of a 0.25% solution of novocaine, 2 ml of a 2% solution of papaverine, 2 ml of a 1% solution nicotinic acid and 10,000 units of heparin. Enter intraarterially. Intravenous administration a small amount novocaine potentiates the effect of drugs used for anesthesia, has an analgesic and anti-shock effect, and therefore it is sometimes used to prepare for anesthesia, during anesthesia (to enhance the effect of the main anesthetic) and in postoperative period(to relieve pain and spasms). Inside take 0.25 - 0.5% solution up to 30 - 50 ml 2 - 3 times a day. Intradermal injections 0.25 - 0.5% solution is recommended for circular and paravertebral blockade for eczema, neurodermatitis, sciatica, etc. Candles (rectal) with novocaine are used as a local anesthetic and antispasmodic for spasms of the smooth muscles of the intestine. Novocain (5 - 10% solution) is also used using the electrophoresis method. Due to the ability of the drug to reduce the excitability of the heart muscle, it is sometimes prescribed for atrial fibrillation- injected into a vein 0.25% solution of 2 - 5 ml up to 4 - 5 times. More effective and specifically acting antiarrhythmic drugs are local anesthetics lidocaine and trimecaine and a derivative of novocaine - novocainamide (see). Novocaine is used to dissolve penicillin in order to prolong its action (see Penicillin group drugs). Novocaine is also prescribed in the form intramuscular injections with some diseases that are more common in old age (endarteritis, atherosclerosis, hypertonic disease, spasms coronary vessels and vessels of the brain, diseases of the joints of rheumatic and infectious origin and etc.). Treatment is carried out in a hospital. A 2% solution of novocaine, 5 ml, is injected into the muscles 3 times a week; for a course of 12 injections, after which they take a 10-day break. During the year, the course of treatment is repeated up to 4 times. The effect is seen mainly in early stages diseases associated with functional disorders CNS. Novocaine is generally well tolerated, but it can cause side effects and should be used with caution in all routes of administration. Some patients experience hypersensitivity to the drug (dizziness, general weakness, lowering blood pressure, collapse, shock). allergic reactions may develop skin reactions(dermatitis, peeling, etc.). To identify hypersensitivity initially prescribed novocaine in reduced doses. Intramuscularly injected first 2 ml of a 2% solution, after 3 days in the absence of side effects- 3 ml of this solution and only then proceed to the introduction of a full dose - 5 ml per injection. Higher doses of novocaine (for adults): single dose when taken orally 0.25 g, when injected into muscles (2% solution) - 0.1 g (5 ml), when injected into a vein (0 , 25% solution) - 0.05 g (20 ml); daily intake of 0.75 g; when injected into muscles (2% solution) and into a vein (0.25% solution) - 0.1 g. For infiltration anesthesia, the following higher doses are established (for adults): first single dose at the beginning of the operation - no more than 1.25 g of a 0.25% solution (i.e. 500 ml) and 0.75 g of a 0.5% solution (i.e. 150 ml). In the future, during each hour of the operation - no more than 2.5 g of a 0.25% solution (i.e. 1000 ml) and 2 g of a 0.5% solution (i.e. 400 ml). Release form: powder; 0.25% and 0.5% solutions in ampoules of 1; 2; 5; 10 and 20 ml and 1% and 2% solutions 1 each; 2; 5 and 10 ml; 0.25% and 0.5% sterile solutions of novocaine in vials of 200 and 400 ml; 5% and 1O% ointment; candles containing 0.1 g of novocaine. Novocain is part of complex drug"Menovazin" (see). Storage: list B. In well-corked orange glass jars; ampoules and suppositories - in a place protected from light. Rp:. Sol. Novocaini 0.25% 200 ml D.S. For infiltration anesthesia Rp.: Sol. Novocaini 1% 10 ml D.t.d. N. 5 in amp. S. For conduction anesthesia Rp.: Novocaini 1.25 Natrii chloridi 3.0 Kalii chloridi 0.038 Calcii chloridi 0.062 Aq. pro injection. 500 ml M. Steril.! D.S. For anesthesia according to the method of A. V. Vishnevsky Rp .: Novocaini 0.5 Aq. destill. 200 ml M.D.S. Inside 1 tablespoon Rp.: Sol. Novocaini 2% 5ml D.t.d. N. 6 in amp. S. 5 ml into the muscles 1 time in 2 days

Medicine Dictionary. 2005 .

Ozhegov's Explanatory Dictionary Wikipedia

novocaine- NOVOCAINE, a, m The drug is a synthetic substitute for cocaine; used for local anesthesia and treatment. Before the operation, the patient was injected with novocaine ... Explanatory dictionary of Russian nouns

A drug from the group of painkillers; para-aminobenzoic acid diethylaminoethyl ester hydrochloride. N.'s solutions are used for local anesthesia (See Anesthesia), novocaine blockade (See Novocaine blockade), and ... ... Great Soviet Encyclopedia

M. A drug used as an anesthetic. Explanatory Dictionary of Ephraim. T. F. Efremova. 2000... Modern dictionary Russian language Efremova

In this article, you can read the instructions for use medicinal product Novocaine. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of doctors of specialists on the use of Novocain in their practice. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Novocaine, if available structural analogues. Use for anesthesia, blockades and dilution of drugs in adults, children, as well as during pregnancy and lactation.

Novocaine- a local anesthetic with moderate anesthetic activity and a large latitude therapeutic action. Being a weak base, it blocks Na + - channels, prevents the generation of impulses at the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in membranes nerve cells without a pronounced effect on the resting potential.

Suppresses the conduction of not only pain, but also impulses of a different modality. With absorption and direct vascular injection into the bloodstream, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (it has some ganglion-blocking effect), eliminates spasm of smooth muscles, and reduces the excitability of the myocardium and motor areas of the cerebral cortex.

Eliminates the descending inhibitory influences of the reticular formation of the brain stem. Inhibits polysynaptic reflexes. In high doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 h).

Pharmacokinetics

Undergoes complete systemic absorption. The degree of absorption depends on the site and route of administration (especially on vascularization and blood flow rate of administration) and the final dose (amount and concentration). It is rapidly hydrolyzed by plasma and liver esterases with the formation of two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating action) and para-aminobenzoic acid (is a competitive antagonist sulfa drugs and can weaken them antimicrobial action). It is excreted mainly by the kidneys in the form of metabolites, no more than 2% is excreted unchanged.

Indications

• infiltration (including intraosseous) anesthesia;
• for diluting drugs and reducing the pain effect of administered drugs;
• vagosympathetic cervical, pararenal, circular and paravertebral blockades.

Release form

Solution for injection (injections in ampoules) 0.25%, 0.5% and 2%.

Candles rectal 100 mg.

Instructions for use and dosage

Only for procaine solution (active ingredient of the drug Novocain) 5 mg / ml (0.5%).

For infiltration anesthesia, 350-600 mg (70-120 ml) are administered. Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation is not more than 0.75 g (150 ml), then during each hour of the operation - not more than 2 g (400 ml) of the solution.

With pararenal blockade (according to Vishnevsky), 50-80 ml is injected into the perirenal tissue.

With circular and paravertebral blockade, 5-10 ml is injected intradermally. With vagosympathetic blockade, 30-40 ml is administered.

To reduce absorption and prolong the action during local anesthesia, an additional 0.1% solution of epinephrine hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution.

Maximum dose for use in children over 12 years old - 15 mg / kg.

Side effect

• headache;
• dizziness;
• drowsiness;
• weakness;
• increase or decrease blood pressure;
• peripheral vasodilation;
• collapse;
• bradycardia;
• arrhythmias;
• chest pain;
• skin itching;
• skin rash;
• other anaphylactic reactions(including anaphylactic shock);
• urticaria (on the skin and mucous membranes).

Contraindications

• hypersensitivity (including to para-aminobenzoic acid and other local anesthetic esters);
• for anesthesia by the creeping infiltrate method - pronounced fibrotic changes in tissues.

Use during pregnancy and lactation

If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be compared. With caution during childbirth.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

special instructions

Patients require functional monitoring of cardio-vascular system, respiratory system and the central nervous system.

It is necessary to stop monoamine oxidase inhibitors 10 days before administration local anesthetic.

It should be borne in mind that when conducting local anesthesia using the same total dose, the toxicity of procaine is the higher, the more concentrated solution used.

Impact on ability to drive vehicles and mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

drug interaction

Enhances inhibitory effect on the central nervous system medicines for general anesthesia, sleeping pills, sedatives, narcotic analgesics and tranquilizers.

Anticoagulants (sodium ardeparin, sodium dalteparin, sodium danaparoid, sodium enoxaparin, sodium heparin, warfarin) increase the risk of bleeding. When treating the injection site with disinfectant solutions containing heavy metals, the risk of developing local reaction in the form of pain and swelling.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of developing a pronounced decrease in blood pressure. Enhances and prolongs the action of muscle relaxant drugs. Vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic effect.

Novocaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction in the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimiasthenic drugs, cyclophosphamide, demecarium bromide, ecothiopa iodide, thiotepa) reduce the metabolism of local anesthetic drugs.

The metabolite of procaine (para-aminobenzoic acid) is a sulfonamide antagonist.

Analogues of the drug Novocain

Structural analogues according to active substance:

• novocaine bufus;
• Novocain-Vial;
• novocaine base;
• Novocaine solution for injections;
• Procaine hydrochloride.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Novocaine is used in medical practice several decades. The use of novocaine marked the beginning new era anesthesia. The drug is in demand and widely used in medicine.

What is novocaine?

The discovery of novocaine is not accidental, but a natural result of an intensive search. In 1905, the German scientist Alfred Einhorn, as a result of many years of research, synthesized procolin compounds. Procolin hydrochloride has been in production since 1906. Tradename medicines - novocaine, otherwise "new cocaine". The drug, of course, was inferior to the well-known cocaine in terms of the degree of analgesic effect, but the use of novocaine made it possible to refrain from using a substance that leads to drug addiction.

Forms of release of the drug novocaine

1. Ointment;
2. Candles for rectal administration;
3. Solution.

Ointment necessary for eczema, dermatosis, combined with itching and scratching. It is applied twice a day. The skin is lubricated thinly, not rubbed.

Candles well reduce pain with cracks and anus. After bowel cleansing. Enter twice during the day.

Novocaine solution – famous drug local anesthesia. It produces an analgesic effect, reduces the excitation of the brain of the head and the heart muscle. Intravenous administration reduces spasm of smooth muscles. medicinal solution used in the form of injections and orally, for the treatment of toxicosis of pregnant women,. As an anti-shock agent, the use of novocaine is recommended for frostbite and skin. Blockades with this drug reduce the reflex reactions that appear when pathological changes. Subcutaneous administration is prescribed for patients with eczema, sciatica. It is indispensable for dissolving antibiotics, for enhancing and lasting the effect of injected injections. Acts 30 minutes after the drug enters the bloodstream. The use of novocaine is appropriate for many types of anesthesia.

Carrying out novocaine blockade is carried out with a properly prepared solution. a certain norm Bring distilled water to a boil and set aside. Add novocaine powder. Instead of water, saline can be used. The solution should be low concentration up to 0.5%. Use freshly prepared with a temperature of 37-38 degrees. Old and cold solutions should not be used, as healing effect will not be reached.

Small doses of the drug without risk to the development of the fetus are administered to pregnant women with toxicosis. Dental treatment is basically not complete without the use of novocaine. Local anesthesia an injection into the gum will not harm the health of the child. An increase in blood pressure during pregnancy is unacceptable. Novocaine can cope with problems. The medicine will smoothly lower the pressure parameters and provide moderate load on the heart, relax the muscle muscles. Pay close attention to the dosage. Women are allowed to use it in small doses. Often occurring during pregnancy, hemorrhoids cause a lot of suffering. Ointment and suppositories with novocaine can relieve pain. Safe application allowed at any stage of pregnancy. With possible injections with novocaine in complex treatment. It is important to follow the dosage. Large doses can cause vomiting, arrhythmia.

Can novocaine be given to children?

Children under 12 years of age the drug is contraindicated. From 12-18 years of age, the use of novocaine should be done with great caution. As a dilution of antibiotics for injection.

Novocaine for heel spurs

When getting rid of this disease, the technique with the use of an anesthetic has been effectively recommended. Its essence lies in chipping the heel in the area heel spur novocaine solution. A 0.5% concentration of the drug is used. Novocaine blockade is done in acute period twice during the day.

Novocaine storage - expiration date

I would like to emphasize that the drug should be stored at low temperatures without access to light. At proper storage the shelf life will be three years. Use in consultation with your doctor.

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

Novocain injections (in ampoules): instructions for use

Compound

1 ml of solution contains: active substance- procaine 0.005 or 0.02 g;

Excipients: solution of hydrochloric acid 0.1 M - up to pH 3.8 - 4.5, water for injection - up to 1 ml.

Description

Clear, colorless or slightly yellowish liquid.

pharmachologic effect

Pharmacotherapeutic group:

preparations for local anesthesia - para-aminobenzoic acid esters.

ATX code - N01BA02.

Indications for use

Infiltration, conduction, epidural and spinal anesthesia, intraosseous anesthesia, anesthesia of the mucous membranes (in ENT practice); vagosympathetic and paranephric blockade. Circular and paravertebral blockade in eczema, neurodermatitis, ischalgia.

To potentiate the action of fixed drugs for anesthesia; for cupping pain syndrome different genesis.

As an adjuvant for certain diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and brain vessels, diseases of the joints of rheumatic and infectious genesis. For dissolution of penicillin in order to lengthen its duration.

Contraindications

Hypersensitivity to procaine.

Dosage and administration

Individual, depending on the type of anesthesia, route of administration, indications.

For infiltration anesthesia 350 - 600 mg - 0.5% solution;

for conduction anesthesia - 2% solution (up to 25 ml);

for epidural - 2% solution (20-25 ml).

To reduce absorption and prolong the action during local anesthesia, an additional 0.1% solution of epinephride hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution.

With pararenal blockade (according to A.V. Vishnevsky), 50 - 80 ml of a 0.5% solution are injected into the perirenal tissue.

Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation is not higher than 0.75 g of a 0.5% solution (150 ml). In the future, for each hour - no more than 2 g (400 ml of a 0.5% solution).

The maximum dose for use in children is up to 15 mg / kg.

To eliminate the pain syndrome, it is administered intramuscularly or intravenously slowly, 1-15 ml of a 0.5% solution 2-3 times a day.

In the treatment of endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and cerebral vessels, diseases of the joints of rheumatic and infectious origin in elderly patients, a 2% solution of novocaine, 5 ml, is injected into the muscles 3 times a week; for a course of 12 injections.

If necessary, 4 courses are possible during the year. Treatment is carried out in a hospital.

Side effect

Arterial hypotension, collapse, dizziness, weakness, urticaria, allergic reactions, anaphylactic shock.

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, "cold" sweat, increased respiration, tachycardia, lowering blood pressure, up to collapse, apnea, methemoglobinemia. The action on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, motor excitation.

Treatment: maintaining adequate pulmonary ventilation with oxygen inhalation, intravenous administration of short-acting drugs for general anesthesia, in severe cases, detoxification and symptomatic therapy.

Interaction with other drugs

When administered intravenously, it enhances the inhibitory effect on the central nervous system of general anesthesia, hypnotics, sedatives, narcotic analgesics and tranquilizers.

The procaine metabolite para-aminobenzoic acid is a competitive antagonist of sulfonamides and may weaken their antimicrobial activity.

Name:

Novocain (Novocainum)

Pharmacological
action:

Local anesthetic with moderate anesthetic activity and a wide breadth of therapeutic action.
Being a weak base, it blocks sodium channels, displaces calcium from receptors located on inner surface membranes and, thus, prevents the generation of impulses at the endings of sensory nerves and the conduction of impulses along nerve fibers.
Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduction of not only pain, but also impulses of a different modality.
When released into the systemic circulation reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (has a weak ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor areas of the cerebral cortex.
Compared with lidocaine and bupivacaine, procaine has a less pronounced anesthetic effect and, therefore, has a relatively low toxicity and a greater therapeutic breadth.

Pharmacokinetics
Poorly absorbed through mucous membranes.
At parenteral administration well absorbed, rapidly hydrolyzed by plasma and tissue esterases with the formation of two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and PABA. T1 / 2 - 0.7 min.
It is excreted mainly by the kidneys in the form of metabolites - 80%.

Indications for
application:

Infiltration, conduction, epidural and spinal anesthesia;
- intraosseous anesthesia;
- anesthesia of mucous membranes (in ENT practice); vagosympathetic and pararenal blockade;
- circular and paravertebral blockade for eczema, neurodermatitis, ischalgia.

I/V: to potentiate the action of fixed drugs for anesthesia; for the relief of pain syndrome of various origins.
V/m: to dissolve penicillin in order to prolong its duration; as aid with some diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and brain vessels, diseases of the joints of rheumatic and infectious origin.
Rectally: hemorrhoids, spasms of smooth muscles of the intestine, anal fissures.
As an adjuvant, procaine used intravenously and internally with arterial hypertension, late toxicosis of pregnant women with hypertensive syndrome, spasms of blood vessels, phantom pains, peptic ulcer of the stomach and duodenum, UC, itching, neurodermatitis, eczema, keratitis, iridocyclitis, glaucoma.

Mode of application:

With infiltration anesthesia the highest doses at the beginning of the operation are not more than 500 ml of a 0.25% solution or 150 ml of a 0.5% solution, then every hour up to 1000 ml of a 0.25% solution or 400 ml of a 0.5% solution for every hour.
For conduction anesthesia use 1-2% solutions, with epidural(injection of a local anesthetic into the epidural space) spinal canal for the purpose of anesthesia of the areas innervated spinal nerves) -20-25 ml of 2% solution, for spinal- 2-3 ml of 5% solution, with pararenal blockade- 50-80 ml of 0.5% solution, with vagosympathetic blockade- 30-100 ml of 0.25% solution, as a local anesthetic and antispasmodic(relieves spasms) means the drug is used in suppositories of 0.1 g.

Side effects:

maybe: arterial hypotension, collapse, dizziness, weakness, urticaria, allergic reactions, anaphylactic shock.

Contraindications:

Individual intolerance.
It should be borne in mind that when conducting local anesthesia with the use of the same total dose the higher the toxicity of procaine the more concentrated the applied solution is.
Procaine penetrates slowly through intact mucous membranes, so it is not very effective for surface anesthesia.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms.
During the period of treatment, it is necessary to be careful when driving and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction
other medicinal
by other means:

Prolongs the neuromuscular blockade caused by suxamethonium (since both drugs are hydrolyzed by plasma cholinesterase).
Use simultaneously with MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of developing arterial hypotension . The toxicity of procaine is increased by anticholinesterase drugs (suppressing its hydrolysis).
The metabolite of procaine (para-aminobenzoic acid) is a competitive antagonist of sulfanilamide drugs and can weaken their antimicrobial effect.
When treating the injection site of local anesthetic with disinfectant solutions containing heavy metals, increased risk of developing a local reaction in the form of pain and swelling.
Potentiates the action of direct anticoagulants.
The drug reduces the effect of anticholinesterase drugs on neuromuscular transmission.
Cross-sensitization is possible.

Pregnancy:

Use during pregnancy is possible subject to good tolerance.
During lactation, the use of the drug is possible after a preliminary thorough assessment of the expected benefits of therapy for the mother and potential risk for a baby.
When used during childbirth, the development of bradycardia, apnea, and seizures in the newborn is possible.

Overdose:

It is possible only with the use of novocaine in high doses.
Symptoms: pallor skin and mucous membranes, dizziness, nausea, vomiting, increased nervous excitability, "cold" sweat, tachycardia, lowering blood pressure almost to collapse, tremor, convulsions, apnea, methemoglobinemia, respiratory depression, sudden cardiovascular collapse.
action on the central nervous system manifested by a feeling of fear, hallucinations, convulsions, motor excitation. In cases of overdose, the administration of the drug should be stopped immediately. During local anesthesia, the injection site can be punctured with adrenaline.
Treatment: general resuscitation which include inhalation of oxygen, if necessary - holding artificial ventilation lungs. If convulsions continue for more than 15-20 seconds, they are stopped intravenous administration thiopental (100-150 mg) or diazepam (5-20 mg). With arterial hypotension and / or myocardial depression, ephedrine (15-30 mg) is administered intravenously, in severe cases- detoxification and symptomatic therapy.
In the event of the development of intoxication after the injection of novocaine into the muscles of the leg or arm, an urgent application of a tourniquet is recommended to reduce the subsequent entry of the drug into the general circulation.