Curantyl solution. Dosage form Curantil: solution for injection. Terms of dispensing from pharmacies

One tablet contains

active substance - dipyridamole 25 mg,

Excipients:

core composition: corn starch, lactose monohydrate, sodium starch glycolate (type A), gelatin, anhydrous colloidal silicon dioxide, magnesium stearate;

shell composition: hypromellose, talc, macrogol 6000, titanium dioxide (E 171), quinoline yellow (E 104), simethicone emulsion

Description

Yellow, round, flat-cylindrical, film-coated tablets with nearly plane-parallel surfaces

Pharmacotherapeutic group

Anticoagulants. Platelet aggregation inhibitors, excluding heparin. Dipyridamole.

ATX code B01AC07

Pharmacological properties

Pharmacokinetics

After oral administration, dipyridamole is rapidly absorbed from the gastrointestinal tract (mostly in the stomach and partly in the small intestine).

After oral administration, the maximum plasma concentration of dipyridamole is reached after 1 hour. Dipyridamole is almost completely bound to plasma proteins. It accumulates in the heart and in erythrocytes, and is metabolized in the liver by binding to glucuronic acid. The elimination half-life is 20-30 minutes. Dipyridamole is excreted in the bile as a monoglucuronide.

Pharmacodynamics

Curantil® N 25 has an inhibitory effect on platelet aggregation and improves microcirculation. The drug has a mild vasodilating effect.

The mechanism by which dipyridamole has an inhibitory effect on platelet aggregation may be due to inhibition of uptake of adenosine (which is an inhibitor of platelet reactivity), inhibition of platelet phosphodiesterase, or stimulation of prostacyclin (PGI2) release.

Dipyridamole inhibits the absorption of adenosine by endothelial cells, erythrocytes and platelets. Thus, after the use of dipyridamole, an increased concentration of adenosine in the blood was observed, and the platelet aggregation and thrombus formation provided by it decreased. In addition, the vasodilating effect of adenosine was enhanced.

The enzyme phosphodiesterase destroys the aggregation-inhibiting cyclic adenosine monophosphate (c-AMP) in platelets. Dipyridamole inhibits platelet phosphodiesterase, leading to the accumulation of cAMP in them.

Indications for use

Treatment and prevention of cerebrovascular accidents by ischemic type

Prevention of arterial and venous thrombosis, as well as their complications

Prevention of thromboembolism after heart valve replacement surgery

Dosage and administration

Unless otherwise prescribed, the following dosage instructions apply:

To reduce platelet aggregation, it is recommended to take 75-225 mg of dipyridamole / day (3-9 tablets of Curantyl® N 25, film-coated), divided into several doses. In severe cases, the dose may be increased to 600 mg dipyridamole/day.

For the treatment and prevention of disorders of cerebral circulation, it is recommended to take 3 tablets of Curantyl® N 25 3-6 times a day (225-450 mg of dipyridamole). The maximum dose of dipyridamole should not exceed 450 mg/day (equivalent to 18 film-coated tablets of Curantyl® N 25).

Therapy should be started with gradually increasing doses, and the film-coated tablets should be taken on an empty stomach, without cracking or breaking them, and also with liquid.

The duration of treatment and the dose should be set depending on individual needs and tolerability.

Curantyl® N 25 is suitable for long-term treatment.

Side effects

Adverse reactions that occur during the use of Curantil® N 25 in therapeutic doses are usually mild and transient.

Vomiting, diarrhea, nausea

Dizziness, headache (including headache of vascular origin) and muscle pain (usually these side effects disappear with longer use of Curantyl® N 25)

Hypersensitivity reactions of the type of rapidly transient skin rash and urticaria

isolated cases

Increased tendency to bleed during or after surgery

Exacerbation of coronary heart disease

angina pectoris

myocardial infarction

Frequency unknown

Pain in the epigastrium

Palpitations, tachycardia, bradycardia, flushing of blood to the face, coronary steal syndrome (when using doses of more than 225 mg / day).

Thrombocytopenia, changes in the functional properties of platelets, increased tendency to bleed

Weakness, feeling of fullness in the ear, noise in the head, arthritis, rhinitis

As a result of a possible vasodilating effect, Curantyl®N 25 in high doses may cause hypotension, fever and tachycardia, especially in patients taking other vascular drugs.

Dipyridamole has been shown to be a constituent of gallstones.

Contraindications

Recent myocardial infarction

Unstable angina

Widespread stenosing atherosclerosis of the coronary arteries

subaortic stenosis

Decompensated heart failure

Arterial hypotension, collapse

Severe cardiac arrhythmias

Hemorrhagic diathesis

Diseases with a tendency to bleeding (gastric ulcer and 12 duodenal ulcer, etc.)

Hypersensitivity to any of the components of the drug

Children and adolescents up to 18 years of age

lactation period

Drug Interactions

Xanthine derivatives (contained, for example, in coffee and tea) can weaken the vasodilating effect of Curantyl® N 25.

It should be borne in mind that with the simultaneous use of Curantyl® N 25 and anticoagulants or acetylsalicylic acid or clopidogrel, the antithrombotic properties of the latter are enhanced. If Curantil® N 25 is used simultaneously with acetylsalicylic acid or anticoagulants, then it is necessary to take into account information about the risk and incompatibility of these drugs.

Dipyridamole may enhance the effect of antihypertensive drugs.

Dipyridamole may reduce the cholinergic properties of cholinesterase inhibitors.

The use of antacids may reduce the effectiveness of Curantyl® N 25.

β-lactam antibiotics, tetracycline and chloramphenicol increase the effect of dipyridamole.

Dipyridamole increases the concentration of adenosine in the blood plasma and enhances its vasodilating effect. If there is an urgent need for co-administration with dipyridamole, the dosage of adenosine should be adjusted. Dipyridamole may also inhibit the absorption of fludarabine and reduce its effectiveness.

Dipyridamole may cause a slight increase in the absorption of digoxin.

special instructions

Pregnancy

The safety of using Curantil® N 25 during pregnancy has not been established; therefore, the drug should not be used during pregnancy, especially in the first trimester, unless the expected benefit to the patient is greater than the possible risk to the fetus

Curantil® N25 contains lactose, therefore, it is not recommended for patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The medicine Curantil is prescribed mainly for the treatment of diseases of the heart and blood vessels. The drug is used to thin the blood, as well as to lower pressure..

Curantyl is included in a comprehensive treatment regimen for diseases of the urinary tract and kidneys. The medicine is often prescribed during pregnancy to normalize the blood circulation of the placenta.

pharmachologic effect

The active substance of the drug is dipyridamole. As a rule, the drug Curantil is prescribed to expand the small vessels of the heart muscle. Large doses of the drug are taken to ensure the delivery of oxygen to the cells. In addition, the angioprotective drug provides microcirculation in the blood vessels of the brain, kidneys, and eyeballs.

The group of the drug to which Curantil belongs is antiplatelet agents. Curantyl for pregnant women is prescribed to ensure a full blood supply to the placenta. The drug stimulates blood microcirculation, eliminates the lack of oxygen, thus preventing intrauterine malformations of the embryo and prevents placental abruption.

If the drug is prescribed in combination with acetylsalicylic acid, then Curantyl prevents platelets from pooling and the formation of blood clots. This combination of medications is prescribed for patients with atherosclerosis, thrombosis, and patients who have had a stroke to avoid recurrence of an attack.

Why is the drug prescribed for diseases of the urinary system?

Mainly, the drug is included in the therapy of glomerulonephritis, pyelonephritis, interstitial nephritis. In the treatment of chronic glomerulonephritis, Curantil must be taken in combination with immunosuppressants and heparin.

For Curantyl, the indications for use are as follows:

• hypertension (starting from the second degree);
• cerebral infarction;
• cholesterol deposits in the vessels of the heart (atherosclerosis);
• chronic insufficiency of blood supply to the brain;
• ischemia of the heart;
• prevention of thrombosis;
• angina;
• oxygen starvation of the fetus;
• violation of the blood supply to the placenta.

The drug can be used to prevent seasonal respiratory viral infections. Dipyridamole stimulates the production of interferon (a compound that the body produces to protect against pathogenic viruses).

Antiaggregant Curantil in the treatment of inflammatory processes in the kidneys is prescribed in large doses. Dipyridamole as part of the drug reduces the amount of protein in the urine, contributes to a decrease in blood in the urine.

Important! When using large doses of Curantyl, severe headaches are possible, therefore, a minimum dose is prescribed in the first few days. The drug can be taken by adults and children over 12 years of age.

Side effects and contraindications

The drug for blood thinning is produced in three dosage forms:

• dragee;
• tablets;
• ampoules with solution for intravenous injections.

The drug can harm patients with any pathologies of blood microcirculation in the acute stage, so Curantyl is contraindicated for them. The reaction of the child's body to the drug is also little studied, so it is not used in the treatment of children under 12 years of age.

Curantyl has contraindications:

The option of individual intolerance to the drug is not excluded. Side effects appear in most cases if Curantyl is taken longer than the prescribed period for a long time.

In rare cases, Curantil tablets can give mild side effects:

If the patient takes Curantil for a long time, he may develop intercoronary steal syndrome. As a result of the occurrence of such a condition, a heart attack or an attack of angina pectoris can occur.

In case of an overdose, a sharp decrease in pressure, fainting, angina pectoris is possible. If symptoms similar to an overdose of a drug appear, it is necessary to wash the stomach, use a sorbent. With a persistent attack of angina pectoris, it is recommended to take a nitroglycerin tablet.

Curantyl has an advantage over other blood thinning drugs - it does not provoke the development of an ulcer of the gastrointestinal tract. The drug rarely changes the composition of the blood (decrease in the number of platelets).

You can take Curantil in the early stages of pregnancy, however, in the 2nd and 3rd trimester, the appointment of the drug should be considered and appropriate due to the risk of bleeding.

Why is Curantyl prescribed to pregnant women:

Sometimes the medicine is used during pregnancy as a prophylaxis for respiratory infections in the demi-season period.

Dosage and application features

The duration of the use of Curantyl depends on the course of the disease. With severe pathologies of the kidneys (chronic glomerulonephritis), the drug can be taken up to 2.5 months.

The maximum dose of the drug is 600 mg. To avoid side effects when taken simultaneously with acetylsalicylic acid, the dose of Curantyl should be reduced by 2 times.

1 tablet of Curantyl contains 75 mg of dipyridamole. With the normalization of blood microcirculation in the kidneys, 3 to 6 tablets per day are prescribed. This dosage can be increased if necessary up to 9 tablets.

The drug should not be chewed or sucked. It is recommended to use the drug on an empty stomach or 2 hours after a meal, be sure to drink the tablets with a sufficient amount of water.

During the course of treatment, it is necessary to take into account the features of the interaction of the drug with other drugs:

Important! It is strictly forbidden to change the dosage and duration of the course of treatment without prior agreement with the attending physician.

Pharmaceutical companies produce many medicines similar to Curantil: Anginal, Cardioflux, Aprikor, Trombonil, Viscor, Vadinar, Dipyridamole. However, in the treatment of infectious diseases of the kidneys, bladder, it is recommended to use Curantil, since the drug is well tolerated by patients, it is allowed during lactation. The effectiveness of Curantyl has also been proven by years of use in the complex therapy of nephrological diseases.

Curantil 25 is a drug with immunomodulatory, angioprotective and antiaggregatory effects.

Release form and composition

Curantyl 25 is available in the following forms:

• dragees (Kurantil 25): round, with a smooth, uniform surface, yellow or greenish-yellow in color (100 pieces in colorless glass bottles, one bottle in a cardboard box);
• film-coated tablets (Kurantil N25): round, flat-cylindrical, yellow (120 pieces in colorless glass bottles, one bottle in a carton box).

Composition for 1 dragee:

• auxiliary components: magnesium stearate, gelatin, corn starch, colloidal silicon dioxide, lactose monohydrate, talc;
• dragee shell: calcium carbonate, talc, liquid dextrose, polyvidone, sucrose, magnesium hydroxycarbonate, macrogol 6000, carnauba wax, titanium dioxide, quinoline yellow dye.

Composition per 1 film-coated tablet:

• active ingredient: dipyridamole - 25 mg;
• auxiliary components: magnesium stearate, gelatin, corn starch, anhydrous colloidal silicon dioxide, lactose monohydrate, sodium carboxymethyl starch;
• tablet shell: talc, macrogol 6000, hypromellose, titanium dioxide, simethicone emulsion, quinoline yellow dye.

Pharmacological properties

Pharmacodynamics

The spectrum of action of Curantyl 25:

• increases the content of adenosine and increases the synthesis of adenosine triphosphoric acid in the myocardium;
• improves myocardial contractility;
• reduces the resistance of the coronary arteries (by reducing the resistance in small branches and arterioles);
• increases the number of collaterals and blood flow in them;
• reduces the total peripheral vascular resistance;
• normalizes the outflow of blood from the veins;
• reduces platelet aggregation;
• reduces blood pressure;
• corrects blood flow in the placenta;
• reduces the resistance of cerebral vessels;
• eliminates hypoxia and promotes the accumulation of glycogen in the tissues of the fetus;
• prevents dystrophic changes in the placenta (in case of a threat of preeclampsia).

Curantyl is a derivative of pyrimidine and, like other derivatives of this substance, induces interferon and modulates the functional activity of the interferon system; the drug increases the body's nonspecific resistance to viral infections.

Pharmacokinetics

Dipyridamole is rapidly absorbed from the stomach. Absorption from the small intestine is negligible. Within one hour after taking the drug, its maximum plasma concentration is reached. Dipyridamole is almost 100% bound to plasma proteins. The main depot of the drug is in erythrocytes and cardiac muscle.

Metabolism occurs in the liver by binding to glucuronic acid. Curantyl is excreted in the bile as a monoglucuronide metabolite. The half-life is about 10 hours.

Indications for use

• microcirculation disorders of any origin (in complex treatment);
• encephalopathy;
• prevention of thrombosis of arteries and veins, as well as treatment of their complications;
• primary and secondary prevention of coronary heart disease (especially in patients with intolerance to acetylsalicylic acid);
• treatment, as well as prevention of cerebrovascular accidents of the ischemic type (cerebral infarction);
• prevention of thromboembolic complications after a heart valve replacement procedure;
• treatment and prevention of acute respiratory viral infections and influenza (as an interferon inducer and immunomodulatory drug).

In complicated pregnancy, Curantyl 25 is prescribed for the prevention of placental insufficiency.

Contraindications

• unstable angina;
• severe heart rhythm disturbances;
• low blood pressure;
• a sharp drop in blood pressure and a deterioration in the blood supply to vital organs (collapse);
• acute myocardial infarction;
• subaortic stenosis of the aorta;
• severe arterial hypertension;
• atherosclerosis of the coronary arteries of the heart (common stenosing);
• heart failure in the stage of decompensation;
• hemorrhagic diathesis;
• insufficiency of liver function;
• chronic renal failure;
• obstructive pulmonary disease in a chronic form;
• peptic ulcer of the duodenum and stomach and other conditions with an increased risk of bleeding;
• children's age (under 12 years old);
• hypersensitivity to the main or auxiliary ingredients of the drug.

Curantil 25: instructions for use (dosage and method)

Curantyl 25 should be taken before meals (on an empty stomach) with a small amount of water or other liquid. The dragee or tablet must be swallowed whole, without biting or breaking.

The dosage is selected individually, taking into account the severity of the disease and the patient's response to treatment. The duration of the therapeutic course is determined by the doctor.

• coronary heart disease: 75 mg three times a day (it is possible to increase the daily dose under the supervision of a specialist);
• treatment and prevention of cerebrovascular accidents: 75 mg three to six times a day (the maximum dose of dipyridamole is 450 mg per day);
• decrease in platelet aggregation: 75–225 mg per day in divided doses (if necessary, it is possible to increase the daily dose to 600 mg);
• prevention of acute respiratory viral infections and influenza (especially during the period of rising incidence): 50 mg per day in one dose; Curantyl 25 is taken once a week for 4-5 weeks;
• prevention of recurrence of acute respiratory viral infections in patients who often suffer from these infections: 100 mg per day (in two doses with an interval of 2 hours); Curantyl 25 is taken once a week for 8-10 weeks.

Side effects

• digestive system: loose stools, nausea, vomiting, epigastric pain (the listed side effects, as a rule, disappear during treatment with further use of the drug);
• cardiovascular system: flushing of the skin of the face, tachycardia (especially in the case of combination with other vasodilators), lowering blood pressure, bradycardia, palpitations, flushing of the face, coronary steal syndrome (if the daily dose of Curantyl 25 is more than 225 mg);
• central nervous system: noise in the head, dizziness, headache;
• blood coagulation system: bleeding, a decrease in the number of platelets and a change in their functional properties; isolated cases - increased bleeding during or after surgical operations;
• allergic reactions: urticaria, skin rash;
• other reactions: rhinitis, ear congestion, muscle pain, arthritis, weakness.

When using Curantyl 25 in therapeutic doses, the listed undesirable effects, as a rule, are insignificant and are transient.

Overdose

Symptoms of an overdose of Curantyl 25 are a feeling of hot flashes, dizziness, lowering blood pressure, tachycardia, weakness, angina pectoris.

In case of an overdose of the drug, it is necessary to induce artificial vomiting, wash the stomach and take activated charcoal. The vasoconstrictive effect of dipyridamole can be stopped by slow intravenous administration of aminophylline (at a rate of 50-100 mg / min). If angina symptoms persist, nitroglycerin (sublingual) is prescribed.

special instructions

Coffee and tea may reduce the vasodilating effect of the drug, since these drinks contain xanthine derivatives.

Influence on the ability to drive vehicles and complex mechanisms

While taking Curantyl 25, it is necessary to drive vehicles and work with other complex mechanisms with extreme caution, since a sharp drop in blood pressure during treatment with the drug can lead to a deterioration in psychomotor abilities.

Use during pregnancy and lactation

Curantyl 25 during pregnancy is used according to indications (prescribed by the attending physician).

During breastfeeding, dipyridamole can be used only in cases where the expected benefit to the mother outweighs the potential risk to the child.

Application in childhood

Curantyl 25 should not be prescribed to children under 12 years of age, since clinical experience with its use in this group of patients is limited.

For impaired renal function

Curantyl 25 is contraindicated in patients with chronic renal failure.

For impaired liver function

Curantyl 25 is contraindicated in patients with hepatic insufficiency.

drug interaction

The drug enhances the antithrombotic effect of acetylsalicylic acid and anticoagulants, resulting in an increased risk of hemorrhagic complications.

According to the instructions, Curantyl 25 increases the therapeutic effect of antihypertensive drugs.

Xanthine derivatives reduce the vasodilating effect of dipyridamole.

The drug may cause a weakening of the anticholinergic activity of cholinesterase inhibitors.

Analogues

The analogues of Curantyl 25 are: Dipyridamole, Dipyridamole-Ferein, Curantyl N75, Persantin, Parsedil, Sanomil-Sanovel, Dipyridamole-FPO.

Terms and conditions of storage

Store in a dark place, out of the reach of children, at a temperature not exceeding 30 °C.

Shelf life: Curantyl 25 (dragee) - 5 years, Curantyl N25 (film-coated tablets) - 3 years.

Description of the dosage form solution for injection Curantil

Pharmacological action solution for injection Curantil

It is an antagonist of the endogenous ADP aggregant, inhibits PDE, while reducing the release of aggregation activators from platelets - thromboxane, ADP, serotonin, etc., increases the synthesis of prostacyclin PgI2 by the endothelium of the vascular tissue, which prevents platelet aggregation. It reduces the adhesiveness of platelets, prevents the formation of blood clots in the vessels and a decrease in blood flow in the focus of ischemia. The antiplatelet effect occurs at a plasma concentration of 0.1 μg / ml. As an antiplatelet drug, it is often used in combination with ASA. Dose-dependently lengthens the pathologically shortened life of platelets.

Expands the coronary arteries, especially unchanged, causes the phenomenon of stealing. It is an interferon inducer, has a modulating effect on the functional activity of the interferon system, increases the reduced production of interferon alpha and gamma by blood leukocytes in vitro. Increases nonspecific antiviral resistance to viral infections.

Dipyridamole stress echocardiography in the diagnosis of coronary artery disease in patients with angiographically unchanged coronary arteries is characterized by high sensitivity combined with high specificity (91 and 83%, respectively); the sensitivity of this test is higher in multivessel disease in patients with well-developed collaterals and in patients with reduced regional myocardial perfusion.

Normalizes venous outflow, reduces the incidence of deep vein thrombosis in the postoperative period. Improves microcirculation in the retina of the eye, renal glomeruli. Reduces the tone of cerebral vessels, is effective in dynamic disorders of cerebral circulation. According to the angiographic study, the combination of ASA with dipyridamole slows down the progression of atherosclerosis.

In obstetric practice, it corrects placental blood flow, prevents dystrophic changes in the placenta (with the threat of preeclampsia), eliminates fetal tissue hypoxia and promotes the accumulation of glycogen in them.

Pharmacokinetics solution for injection Curantil

Precautions for injection Curantil

Dosing regimen Injection solution Curantil

For the prevention of thromboembolic syndrome, stent thrombosis and coronary artery bypass grafts - on the first day, 50 mg together with ASA, then 100 mg, the frequency of administration is 4 times a day (cancel 7 days after surgery, provided that ASA is continued at a dose of 325 mg / days) or 100 mg 4 times a day for 2 days before surgery and 100 mg 1 hour after surgery (if necessary in combination with warfarin).

With coronary insufficiency - inside, 25-50 mg 3 times a day; in severe cases at the beginning of treatment - 75 mg 3 times a day, then the dose is reduced; daily dose - 150-200 mg.

For the treatment of chronic obliterating diseases of the arteries of the lower extremities - 75 mg 3 times a day; a course of treatment of 2-3 months (it is advisable to combine with small doses of ASA). Parenterally - in the absence of conditions for oral administration, intramuscularly or intravenously slowly, at 5-10 mg, the infusion rate should not exceed 200 mcg / min. The daily dose is 150-200 mg. For children, the daily dose is 5-10 mg / kg.

For diagnostic purposes - 300-400 mg directly during the stress echocardiogram or 45 minutes before the injection of the radiopharmaceutical.

Contraindications solution for injection Curantil

Indications for use solution for injection Curantil

Treatment and prevention of cerebrovascular accidents by ischemic type; encephalopathy.

Prevention of placental insufficiency in complicated pregnancy.

Microcirculation disorders of any origin (as part of complex therapy), chronic obliterating diseases of the vessels of the lower extremities, especially in the presence of risk factors (arterial hypertension, smoking).

Treatment and prevention of influenza and SARS.

Treatment and prevention of DIC in children with infectious toxicosis and sepsis, three-component treatment of glomerulonephritis (complex therapy), platelet suppression syndrome in children.

Conducting dipyridamole-thallium-201 perfusion scintigraphy with physical activity, dimiridamole stress echocardiography.

Side effect solution for injection Curantil

From the digestive system: nausea, vomiting, diarrhea, epigastric pain.

On the part of the blood and the hemostatic system: thrombocytopenia, changes in the functional properties of platelets, bleeding, increased bleeding.

Other: weakness, dizziness, sensation of stuffiness in the ear, noise in the head, headache, flushing of the skin of the face, arthritis, myalgia, rhinitis, allergic reactions.

Special instructions for injection Curantil

In coronary steal syndrome, aminophylline is indicated to improve intracardiac blood flow.

Interaction solution for injection Curantil

Xanthine derivatives containing caffeine weaken the antithrombotic effect.

Weakens the action of cholinesterase inhibitors.

Beta-lactam antibiotics, tetracyclines and chloramphenicol increase the effect.

Antacids reduce the maximum concentration due to reduced absorption.

Heparin, indirect anticoagulants, thrombolytics increase the risk of hemorrhagic complications.

Curantil is a myotropic vasodilator that effectively slows down platelet aggregation and improves blood circulation in small vessels (capillaries).

The active substance - dipyridamole - in therapeutic dosages improves blood microcirculation in the coronary circulation system, and in higher dosages in other parts of the circulatory system. The main difference between Curantil and organic nitrates and calcium antagonists is that there is no expansion of large coronary vessels.

The maximum concentration of the active substance of the tablets is fixed in the blood plasma within an hour after ingestion.

The appointment of Curantil tablets during pregnancy is indicated to prevent blockage of the blood vessels of the placenta - in some cases, this avoids severe complications associated with insufficient blood supply to the child.

Additionally, Curantil has a pronounced effect of stimulating the human immune system - this is due to the action of dipyridamole (active substance), as a derivative of pyrimidine, and its ability to stimulate the synthesis of interferon. The immunomodulatory effect is of great importance for the prevention and treatment of viral diseases, including SARS and influenza.

Curantil 25, photo

After oral administration, the drug is rapidly absorbed into the LC, mainly already in the stomach and only partially in the small intestine. Metabolism occurs in the liver, by binding to glucuronic acid.

Indications for use

What helps Curantyl? The drug is prescribed in the following cases:

• prevention and treatment of acute myocardial infarction or recovery period;
• stable angina;
• prevention of postoperative thrombosis;
• treatment and prevention of placental insufficiency, especially when it comes to aspirin intolerance;
• prevention of thromboembolism after heart valve replacement surgery;
• microcirculation disorders as part of complex therapy;
• prevention of viral diseases, SARS, influenza.

Reviews of doctors characterize Curantil as an effective and fairly inexpensive drug that effectively copes with its therapeutic goals.

Instructions for use Curantyl, dosage

Tablets are taken orally before meals as a whole, washed down with a small amount of clean water. Dosages depend on indications:

To prevent platelet agglutination: dosage from 75 to 225 mg per day in divided doses, if necessary, the dosage is raised to 600 mg per day.

For the prevention of acute respiratory viral infections and influenza, Curantyl is prescribed 75 mg once a day for a course of 2-2.5 months. To prevent relapses - 100 mg per day according to the scheme: 50 mg Curantil 2 times a day, 1 time per week for 10 weeks.

For the treatment of coronary heart disease - the standard dosage is 1 tablet of Curantil 75 mg every 8 hours. As prescribed by the doctor, it is possible to increase the dosage.

Curantyl is not contraindicated during pregnancy, however, before prescribing it, it is necessary to compare the possible risk to the fetus and the likely benefit.

Side effects and contraindications

Using Curantyl in standard dosages, the risk of side effects is minimal. However, you may experience:

• palpitations, tachycardia (especially with the simultaneous use of other vasodilators);
• bradycardia, flushing of the face, flushing of the skin of the face, drop in blood pressure.
• nausea, vomiting, diarrhea, pain in the epigastric region.
• thrombocytopenia, changes in the functional properties of platelets;
• dizziness, noise in the head;
• headache;
• allergic reactions, skin rash, urticaria;
• weakness, feeling of stuffiness in the ear;
• arthritis, myalgia, rhinitis

In most cases, side effects decrease with longer use of the drug.

Contraindications

The main contraindications to the appointment of Curantyl tablets of any dosage:

• acute myocardial infarction;
• unstable angina;
• widespread stenosing atherosclerosis of the coronary arteries;
• subaortic stenosis of the aorta;
• heart failure in the stage of decompensation;
• arterial hypotension;
• collapse;
• severe arterial hypertension;
• severe cardiac arrhythmias;
• chronic obstructive pulmonary disease;
• chronic renal failure;
• liver failure;
• hemorrhagic diathesis;
• diseases with an increased risk of bleeding (incl.
• peptic ulcer of the stomach and duodenum);
• hypersensitivity to the components of the drug.

Overdose

Symptoms of an overdose of Curantil are associated with the therapeutic effect of the drug to dilate blood vessels - hyperemia, a drop in blood pressure, the appearance of weakness, palpitations, and a feeling of warmth in the body appear.

Treatment - the creation of conditions for the accelerated withdrawal of the active substance: gastric lavage, intake of sorbents. Additionally, intravenous administration of aminophylline at a dosage of 50-100 mg may be required. If an attack of angina pectoris occurs, it is necessary to use nitroglycerin tablets or spray.

Analogues Curantil, list of drugs

You can replace Curantil with analogues in terms of therapeutic effect - these are the following drugs, the list:

1. Clopidogrel.
2. Tromboneti.
3. Plavix.
4. Cardiomagnyl.
5. Aspecard.
6. Godasal.
7. Aspicor.
8. Sylt.
9. Brilinta.
10. Atrogrel.
11. Magnikor.
12. Atherocardium.

Important - instructions for use of Curantil, price and reviews do not apply to analogues and cannot be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Curantil with an analogue, it is important to get expert advice, you may need to change the course of therapy, dosages, etc. Do not self-medicate!