Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations. Dachshund from a utilitarian point of view ♦ Our treatment experience ♦ Release form and composition
Throughout life, the spine of the dog is under great stress. Pathological changes entail pain, discomfort, loss of the ability to move.
To treat the condition, veterinary specialists will use the drug "Prozerin". The medicine is prescribed not only in case of paralysis of various etiologies, but also in other situations when it is necessary to strengthen synoptic impulses.
The drug "Prozerin" temporarily blocks cholinesterase, which leads to the restoration of neuromuscular conduction.
In veterinary medicine, the drug is used in cases of treatment of vertebral hernia (discopathy), with neuritis, paralysis of the limbs, in case of weak labor or delayed appearance of the placenta after childbirth. It can also be prescribed for atony of the intestines and bladder.
Release forms
Prozerin is produced in three forms:
- bitter powder, soluble in water (1:10) and in alcohol (1:5);
- 15 mg tablets;
- ready solution for injection, 1 ml ampoule contains 0.5 mg of active ingredient.
The form of the drug does not affect the occurrence of side effects. The difference in the speed of onset of therapeutic action. It is selected individually, depending on the size of the dog, including.
Instructions for use
Dosage by weight
In the treatment of paralysis and discopathy, the empirical dosage is 0.05 mg/kg dog weight. The duration of the course is 10 days. Dosage adjustments are possible, depending on the tolerance of the drug to the dog.
With weak labor activity, an injection is given subcutaneously, at a dosage of 0.4-1 ml, 3 times with an hourly interval. With a delay in the placenta, 0.4-1 ml twice with an interval of 12 hours.
In large quantities, Prozerin has the opposite effect and leads to a violation of synoptic signals and a deterioration in neuromuscular conduction.
How to give pills?
Intramuscular and subcutaneous injections
When using Prozerin in injections, it is administered subcutaneously and intramuscularly. Subcutaneous administration in the withers provides a slow entry of the active substance into the bloodstream and reduces the manifestation of side effects.
The pain syndrome increases with each next injection of the drug in increasing order. The introduction of the solution into the muscle tissue is possible, but causes a strong negative reaction of the dog's body. Namely: there is shortness of breath, severe salivation, the development of enteritis.
Side effects
While taking the drug in dogs, the following side effects may occur: nausea, vomiting, diarrhea, uncontrolled movements of skeletal muscles, pupillary constriction, slow heart rate, apathy, lethargy, loss of consciousness. With a long course, blood may appear in the urine and the development of a stroke.
It is worth noting that side effects when using Prozerin in one form or another appear in all dogs.
There are also a number of absolute contraindications:
- epilepsy;
- atherosclerosis;
- hypersensitivity;
- peptic ulcers of the stomach and duodenum.
Important! The drug Prozerin has a narrowly targeted effect and a wide range of side effects, as well as cases of individual intolerance. Only a veterinarian can evaluate the clinical picture and the objectivity of the use of this medication. Self-medication is unacceptable!
If it got bad
The drug is far from always well tolerated; in individual cases, all the side effects provided by the manufacturer are especially acute. For example, heart rate along with pressure can drop to critically low readings, creating a direct threat to the dog's life.
An allergic reaction is also possible - anaphylactic shock, itching, rash. If side effects or allergies occur, the dosage of the drug should be reconsidered.
In acute cases (cardiac arrest on the background of Prozerin, critical vital signs), measures are taken to eliminate the symptoms and atropine is administered at the rate of 0.05 mg / kg of the dog's weight or other anticholinergic substances.
Pregnant and lactating
Prozerin is strictly contraindicated in dogs during pregnancy. It increases muscle tone and can cause miscarriage. During feeding, the drug is not recommended. Due to the high penetrating ability, the active substance passes into breast milk and may have a negative effect on puppies.
Puppies
Properties.
White crystalline powder, odorless, bitter taste. Hygroscopic. Easily soluble in water (1:10) and alcohol (1:5).
The solutions are sterilized at 100°C for 30 minutes. Under the influence of light, the drug acquires a pink agaric. Prozerin in the form of 0.5% solution - transparent
colorless liquid, stable at storage.
Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations.
Kind of animal.
livestock
Release form.
Produced in powder, tablets of 0.015 g and ampoules of 10 ml of a 0.5% solution.
Action and application.
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. It restores the course of the acetylcholine cycle in the motor nerve fibers and endings, stimulates the work of neurons, increases the tone and activity of the nerves.
It acts similarly to physostigmine, weaker on carnivores and omnivores, and stronger on horses and cattle.
Stimulates the secretion of the digestive glands, increases tone and increases the contraction of the smooth muscles of the digestive tract, uterus, bladder and skeletal muscles.
Changes the resting stage of the estrous cycle. It is used for barrenness of cows, injected subcutaneously at 0.01 g in the form of a 0.5% solution three times.
A 0.05% solution of prozerin is used in animals with weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract of the bladder, as a ruminator. It is used for paresis and paralysis of the motor nerves, motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, myasthenia gravis, optic nerve atrophy, neuritis. It is an antagonist of curare-like drugs.
With atony of the proventriculus in ruminants, atony of the bladder is also used subcutaneously 2 times a day.
With myasthenia gravis, the drug is prescribed orally or under the skin 2 times a day for 20-30 days.
The drug is administered to animals subcutaneously according to the following scheme: to cows to stimulate labor activity 3-4 ml 3 times with an interval of 1 hour, with retention of the placenta 3-4 ml twice with an interval of 12 hours, to prevent and treat subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours in combination with other methods of treatment, with the ovarian cyst - after 3 days. , with hypofunction of the ovaries 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 ME per 100 kg of body weight, pigs with the same indications 1-2 ml.
Doses subcutaneously:
horses 0.03-0.05 g,
cattle 0.02-0.04 g,
small cattle and pigs 0.005-0.01 g,
dogs 0.0004-0.001 g
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
In case of overdose, poor tolerance and ingestion of prozerin solution into muscle tissue possible side effects due to shortness of breath, enteritis, salivation, anxiety. In such cases, the administration of the drug is stopped. As an antidotan, atropine is prescribed subcutaneously at the rate of 0.05 mg/kg of body weight.
Side effect. From the digestive system: nausea, vomiting, diarrhea, hypersalivation, flatulence, spastic contraction and increased peristalsis.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, loss of consciousness, drowsiness, miosis, visual disturbances, twitching of skeletal muscles (including the muscles of the tongue), convulsions.
From the side of the cardiovascular system: arrhythmias, brady- or tachycardia, AV blockade, junctional rhythm, non-specific ECG changes, lowering blood pressure.
From the respiratory system: shortness of breath, respiratory depression, increased secretion of bronchial glands, increased tone of the bronchi.
Allergic reactions: possible skin rash, itching, anaphylactic reactions.
Others: arthralgia, increased urination, increased sweating.
Overdose.Symptoms:
associated with overexcitation of cholinergic receptors (cholinergic crisis): bradycardia, hypersalivation, miosis, bronchospasm, nausea, increased peristalsis, diarrhea, frequent urination, twitching of the muscles of the tongue and skeletal muscles, the gradual development of general weakness, a decrease in blood pressure. Treatment: reduce the dose or stop treatment, if necessary, introduce atropine (1 ml of a 0.1% solution), metacin and other anticholinergic drugs.
Contraindications. Epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication of the weakened, hypersensitivity to neostigmine methyl sulfate.
Prescribed with caution against the background of anticholinergics, with myasthenia gravis against the background of neomycin, streptomycin, kanamycin and other antibiotics that have an antidepolarizing effect, local and some general anesthetics, antiarrhythmics and a number of other drugs that disrupt cholinergic transmission.
Use during pregnancy and lactation.
Neostigmine methyl sulfate crosses the placental barrier and is excreted in very small amounts in breast milk.
Prozerin during pregnancy and lactation is used only according to strict indications.
drug interaction.
When myasthenia gravis is prescribed in combination with aldosterone antagonists, corticosteroids and anabolic hormones. Atropine, metacin, etc. M-anticholinergics weaken M-cholinomimetic effects (pupil constriction, bradycardia, increased gastrointestinal motility, hypersalivation, etc.). Lengthens and enhances (with parenteral administration) the effect of depolarizing muscle relaxants (ditilin, etc.), weakens or eliminates - antidepolarizing.
store
(list A) in well-closed orange glass jars in a place protected from light at a temperature not exceeding 25 ° C.
"Prozerin" solution for injection 0.05%, 5 ml - drug acetylcholine cycle in the motor nerve fibers and endings, excites the work of neurons, increases the tone and activity of nerves in cattle and small cattle, pigs, dogs.
Description and composition:
Packing: 5 ampoules of 1 ml of 0.05% solution.
Pharmacological properties:
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. Changes the resting stage of the estrous cycle.
Indications:
- When cows are lethargic: 0.01 g is injected subcutaneously in the form of a 0.5% solution, three times.
- With weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract and bladder; as a ruminator. It is used for paresis and paralysis of the motor nerves, for motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, for myasthenia gravis, atrophy of the optic nerve, and neuritis. It is an antagonist of curare-like drugs. With atony of the proventriculus in ruminants, atony of the bladder: subcutaneously 2 times a day.
- With myasthenia gravis: the drug is administered orally or under the skin 2 times a day for 20-30 days.
The drug is administered subcutaneously:
- cows to stimulate labor activity: 3-4 ml 3 times with an interval of 1 hour. When retaining the placenta 3-4 ml 2 times with an interval of 12 hours. For the prevention and treatment of subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours. In combination with other methods of treatment: with an ovarian cyst - after 3 days, with ovarian hypofunction - 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 IU per 100 kg of weight.
- pigs with the same indications 1-2 ml.
Doses for animals:
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
Contraindications: epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication in the weakened, hypersensitivity to neostigmine methyl sulfate.
Description: clear colorless liquid.
Packing: 5 ampoules of 1 ml of 0.05% solution.
Terms and conditions of storage: in a dry, dark place, at a temperature not exceeding 25 ° C. Shelf life - 2 years.
Domestic veterinary drugs
PROZERIN. Proserinum.
Synonyms: vasostigmine, myostigmine, neostigmine methyl sulfate, prostigmine. Properties. White crystalline powder, odorless, bitter taste. Hygroscopic. Easily soluble in water (1:10) and alcohol (1:5). The solutions are sterilized at 100°C for 30 minutes. Under the influence of light, the drug acquires a pink agaric. Prozerin in the form of a 0.5% solution is a clear, colorless liquid, stable during storage.
Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations.
Release form. Produced in powder and in ampoules of 1 ml of a 0.05% solution. Store the drug at room temperature (according to list A), in a place protected from light. Shelf life 2 years.
Action and application. Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, lowers intraocular pressure. It restores the course of the acetylcholine cycle in the motor nerve fibers and endings, stimulates the work of neurons, increases the tone and activity of the nerves.
A 0.05% solution of prozerin is used for animals with weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract and bladder; as a ruminator. It is used for paresis and paralysis of the motor nerves, for motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, for myasthenia gravis, atrophy of the optic nerve, and neuritis. It is an antagonist of curare-like drugs.
The drug is administered to animals subcutaneously according to the following scheme: cows to stimulate labor activity 3-4 ml 3 times with an interval of 1 hour; when retaining the placenta 3-4 ml twice with an interval of 12 hours; for the prevention and treatment of subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours in combination with other methods of treatment; with hypofunction of the ovaries 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 IU per 100 kg of weight; pigs with the same indications 1-2 ml.
Doses subcutaneously: horses 0.03-0.05 g; cattle 0.02-0.04 g; small cattle and pigs 0.005-0.01 g; dogs 0.0004-0.001 g.
In case of overdose, poor tolerance and ingestion of prozerin solution into muscle tissue, side effects are possible in the form of shortness of breath, enteritis, salivation, and anxiety. In such cases, the administration of the drug is stopped. As an antidote, atropine is administered subcutaneously at the rate of 0.05 mg/kg of body weight.
Properties.
White crystalline powder, odorless, bitter taste. Hygroscopic. Easily soluble in water (1:10) and alcohol (1:5).
The solutions are sterilized at 100°C for 30 minutes. Under the influence of light, the drug acquires a pink agaric. Prozerin in the form of 0.5% solution - transparent
colorless liquid, stable at storage.
Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations.
Kind of animal.
livestock
Release form.
Produced in powder, tablets of 0.015 g and ampoules of 10 ml of a 0.5% solution.
Action and application.
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. It restores the course of the acetylcholine cycle in the motor nerve fibers and endings, stimulates the work of neurons, increases the tone and activity of the nerves.
It acts similarly to physostigmine, weaker on carnivores and omnivores, and stronger on horses and cattle.
Stimulates the secretion of the digestive glands, increases tone and increases the contraction of the smooth muscles of the digestive tract, uterus, bladder and skeletal muscles.
Changes the resting stage of the estrous cycle. It is used for barrenness of cows, injected subcutaneously at 0.01 g in the form of a 0.5% solution three times.
A 0.05% solution of prozerin is used in animals with weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract of the bladder, as a ruminator. It is used for paresis and paralysis of the motor nerves, motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, myasthenia gravis, optic nerve atrophy, neuritis. It is an antagonist of curare-like drugs.
With atony of the proventriculus in ruminants, atony of the bladder is also used subcutaneously 2 times a day.
With myasthenia gravis, the drug is prescribed orally or under the skin 2 times a day for 20-30 days.
The drug is administered to animals subcutaneously according to the following scheme: to cows to stimulate labor activity 3-4 ml 3 times with an interval of 1 hour, with retention of the placenta 3-4 ml twice with an interval of 12 hours, to prevent and treat subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours in combination with other methods of treatment, with the ovarian cyst - after 3 days. , with hypofunction of the ovaries 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 ME per 100 kg of body weight, pigs with the same indications 1-2 ml.
Doses subcutaneously:
horses 0.03-0.05 g,
cattle 0.02-0.04 g,
small cattle and pigs 0.005-0.01 g,
dogs 0.0004-0.001 g
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
In case of overdose, poor tolerance and ingestion of prozerin solution into muscle tissue possible side effects due to shortness of breath, enteritis, salivation, anxiety. In such cases, the administration of the drug is stopped. As an antidotan, atropine is prescribed subcutaneously at the rate of 0.05 mg/kg of body weight.
Side effect. From the digestive system: nausea, vomiting, diarrhea, hypersalivation, flatulence, spastic contraction and increased peristalsis.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, loss of consciousness, drowsiness, miosis, visual disturbances, twitching of skeletal muscles (including the muscles of the tongue), convulsions.
From the side of the cardiovascular system: arrhythmias, brady- or tachycardia, AV blockade, junctional rhythm, non-specific ECG changes, lowering blood pressure.
From the respiratory system: shortness of breath, respiratory depression, increased secretion of bronchial glands, increased tone of the bronchi.
Allergic reactions: possible skin rash, itching, anaphylactic reactions.
Others: arthralgia, increased urination, increased sweating.
Overdose.Symptoms:
associated with overexcitation of cholinergic receptors (cholinergic crisis): bradycardia, hypersalivation, miosis, bronchospasm, nausea, increased peristalsis, diarrhea, frequent urination, twitching of the muscles of the tongue and skeletal muscles, the gradual development of general weakness, a decrease in blood pressure. Treatment: reduce the dose or stop treatment, if necessary, introduce atropine (1 ml of a 0.1% solution), metacin and other anticholinergic drugs.
Contraindications. Epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication of the weakened, hypersensitivity to neostigmine methyl sulfate.
Prescribed with caution against the background of anticholinergics, with myasthenia gravis against the background of neomycin, streptomycin, kanamycin and other antibiotics that have an antidepolarizing effect, local and some general anesthetics, antiarrhythmics and a number of other drugs that disrupt cholinergic transmission.
Use during pregnancy and lactation.
Neostigmine methyl sulfate crosses the placental barrier and is excreted in very small amounts in breast milk.
Prozerin during pregnancy and lactation is used only according to strict indications.
drug interaction.
When myasthenia gravis is prescribed in combination with aldosterone antagonists, corticosteroids and anabolic hormones. Atropine, metacin, etc. M-anticholinergics weaken M-cholinomimetic effects (pupil constriction, bradycardia, increased gastrointestinal motility, hypersalivation, etc.). Lengthens and enhances (with parenteral administration) the effect of depolarizing muscle relaxants (ditilin, etc.), weakens or eliminates - antidepolarizing.
store
(list A) in well-closed orange glass jars in a place protected from light at a temperature not exceeding 25 ° C.
