Clindamycin candles analogue is cheap. Cross drug interactions. Indications for use

Part capsules Clindamycin included active ingredient clindamycin (hydrochloride form), also additional ingredients: talc, lactose monohydrate, corn starch, magnesium stearate.

Solution contains the active ingredient clindamycin (a form of phosphate), also auxiliary ingredients: benzyl alcohol, disodium edetate, water.

Cream Clindamycin the composition contains the active ingredient clindamycin (a form of phosphate), also auxiliary ingredients: , castor oil, sodium benzoate, propylene glycol, emulsifier No. 1.

Release form

The tool is produced in the form capsules, solution And vaginal cream.

Gelatin capsules have a purple body and a red cap. Inside contains a powder that may be white or white-yellow color. Capsules are packed into blisters on 8 pieces, in a pack from a cardboard on 2 such blisters.

The solution, which is administered intravenously or intramuscularly, is clear, it may be colorless or slightly yellowish. Contains in ampoules on 2 ml. In blister packs of 5 ampoules, in a cardboard box 2 packs.

Vaginal ointment 2% may have white, yellowish-white, cream shades. Possesses weak specific aroma. It is contained in aluminum tubes of 20 g or 40 g, the applicator is included in the kit.

pharmachologic effect

The substance clindamycin belongs to the group of antibiotics-lincosamides. Has a wide range of effects, is a bacteriostatic.

In the body, it binds to the 50S subunit of the ribosome and inhibits protein synthesis in microorganisms. Shows activity towards Staphylococcus spp.., Streptococcus spp.(the exception is Enterococcus spp.), Streptococcus pneumoniae, anaerobic and microaerophilic Gram-positive cocci, Clostridium tetani, Clostridium perfringens, Corynebacterium diphtheriae, Mycoplasma spp., Bacteroides spp.(including Bacteroides melaningenicus And Bacteroides fragilis). Also shows activity against anaerobic Gram-positive, non-spore-forming bacilli.

Sensitive to this substance most of strains Clostridium perfringens, but other varieties of Clostridium (in particular Clostridium tertium, Clostridium sporogenes) show resistance to this drug. In this regard, in diseases provoked by Clostridium spp. It is recommended to conduct an antibiogram before starting treatment.

The mechanism of action of this drug and its antimicrobial spectrum is close to lincomycin.

The clindamycin phosphate form of the substance is inactive in vitro, but it is rapidly hydrolyzed in vivo to form clindamycin, which exhibits antibacterial activity.

Pharmacokinetics and pharmacodynamics

Clindamycin is completely and rapidly absorbed from the gastrointestinal tract. simultaneous reception food absorption slows down, while the concentration of the substance in the plasma remains unchanged. Penetrates into tissues and body fluids, poorly passes through the BBB, but in case of inflammation of the meninges, the permeability increases.

The maximum concentration in is noted when taken orally after 0.75-1 hours, if carried out intramuscular injection, after 1 hour in adult patients and after 3 hours in children. When administered intravenously, the highest concentration is observed at the end of the infusion.

There are therapeutic concentrations in the blood for 8-12 hours. The half-life is 2.4 hours. It occurs in the liver, while active and inactive are formed. Excretion takes place over 4 days through the kidneys and through the intestines.

With the introduction of the drug intravaginally, about 3% of the administered dose undergoes systemic absorption.

Indications for use

Clindamycin solution and tablets are used for such diseases and conditions:

• diseases of an infectious and inflammatory nature, which were provoked by the action of microorganisms sensitive to clindamycin ;
• infections of the ENT organs, as well as infectious diseases of the upper respiratory tract and lower respiratory tract;
• , ;
• urogenital infections;
• mouth infections, abdominal cavity;
• soft tissue and skin infections;
• septicemia (primarily anaerobic);
• acute and chronic;
• bacterial;
• administration for the prevention of intra-abdominal abscesses and peritonitis after intestinal perforation or after traumatic infection (combined with aminoglycosides).

Cream and gel Clindamycin is used for bacterial vaginosis.

Indications for the use of suppositories with clindamycin:

• bacterial vaginosis, provoked by microorganisms sensitive to the substance.

Contraindications

The use of this remedy is contraindicated:

• at ;
• at myasthenia gravis ;
• with ulcerative ;
• at rare diseases hereditary nature (lactase deficiency, galactose intolerance, glucose-galactose malabsorption);
• for and ;
• at the age of a child under 3 years of age, intravenous and intramuscular administration is contraindicated; at the age of 8 years, capsules are contraindicated;
• high sensitivity to the components of the drug.

Carefully prescribed to people who suffer from severe renal or hepatic insufficiency, elderly patients.

Side effects

When taking the medicine, patients may experience some side effects:

• digestive system: dyspeptic symptoms, jaundice, esophagitis, pseudomembranous enterocolitis, hyperbilirubinemia, , abnormal liver function;
• musculoskeletal system: V rare cases there may be a violation of neuromuscular conduction;
• hematopoiesis: leukopenia, neutropenia, agranulocytosis, thrombocytopenia;
• manifestations of allergies: rash, , sometimes - dermatitis, anaphylactoid manifestations, eosinophilia;
• heart and blood vessels: with the introduction of a solution intravenously and quickly - a decrease, weakness, ;
• local manifestations: pain and (at the injection site), irritation;
• other side effects : superinfection.

When using Clindamycin cream, the following side effects may develop:

• urination: irritation of the mucous membrane of the vagina and vulva, vaginal, vulvovaginitis, trichomonas vaginitis, vaginal infections, disorders monthly cycle, uterine bleeding, vaginal pain, dysuria, the appearance of secretions, , glycosuria, ;
• common manifestations: abdominal pain and cramps, bloating, fungal and bacterial infections, , bad smell from the mouth, inflammatory, lower abdominal pain, upper respiratory infections, back pain, ;
• gastrointestinal system: nausea, , vomit, , dyspepsia, gastrointestinal disorders;
• skin: skin itching, erythema, rash, ;
• endocrine system: ;
• CNS: ;
• respiratory system: nosebleed.

Application instruction of Clindamycin (Way and dosage)

Clindamycin is administered intravenously and intramuscularly at a dose of 300 mg twice a day for adult patients. If treatment of a severe infection is necessary, 1.2-2.7 g of the drug is indicated per day, this dose should be divided into 3-4 injections.

You can not prescribe intramuscularly a single dose of the drug, which exceeds 600 mg. The largest allowable dose for intravenous administration - 1.2 g for 1 hour.

Children who are three years of age should receive a dose of 15-25 mg per 1 kg per day, which must be divided into 3-4 times in equal doses.

In case of severe infection, the dose can be increased to 25-40 mg per 1 kg of body weight, this dose should be divided into 3-4 equal injections.

Dose adjustment is not necessary in patients with severe renal or hepatic insufficiency, provided that the drug is administered at least 8 hours apart.

Before intravenous administration, it is necessary to dilute the agent to a concentration of not more than 6 mg / ml, the resulting solution is administered by drip, the period of administration is from 10 to 60 minutes, depending on the dose. Injection is not recommended. The solvent may be a solution of 0.9% sodium chloride and a solution of 5% dextrose.

Clindamycin tablets, instructions for use

Tablets should be taken orally, adult patients and adolescents over 15 years of age with illnesses moderate receive 1 caps. 4 times a day. If there is a severe infection, the dose can be increased by 2-3 capsules. Children aged 8 to 12 years are prescribed 1 caps. 4 times a day. Do not exceed the dose of 4 caps. per day.

Adolescents from 12 to 15 years old are prescribed 1-2 caps. 3 times a day. Do not exceed the dose of 6 caps. per day.

The instruction on the cream provides for its intravaginal use. It is best to use the remedy at bedtime, for 3-7 days.

Candles with clindamycin are applied intravaginally, 1 pc. 1 per day.

Candles are used before bedtime, the course is 3-7 days. Before use, you need to remove the protective film, insert it deep into the vagina, this should be done in the supine position.

Overdose

If an overdose of the drug has occurred, it may increase negative effects described above. There is no specific, in case of an overdose, symptomatic treatment is carried out.

There is no information about an overdose of the cream. In case of accidental ingestion of the drug, systemic effects may develop, which appear after taking the substance orally.

Interaction

There is an increase in the action of aminoglycosides Streptomycin, , when taken concomitantly with clindamycin.

It activates the influence of competitive muscle relaxants, as well as muscle relaxation caused by n-anticholinergics.

Not compatible with barbiturates , magnesium sulfate, aminophylline.

Antagonism with Chloramphenicol and .

Do not simultaneously prescribe clindamycin and drugs with antidiarrheal action, as the likelihood of developing pseudomembranous colitis increases.

When used simultaneously with opioids, the effect of respiratory depression may increase, up to the development .

There is cross-resistance between Lincomycin and Clindamycin. There is also antagonism between Erythromycin and Clindamycin.

Terms of sale

Can be bought with a doctor's prescription.

Storage conditions

The solution and capsules should be stored in a dark place, the temperature should be from 15 ° to 25 ° C. Keep away from children.

Best before date

The solution is stored for 2 years, capsules - 3 years.

special instructions

Possible manifestation of pseudomembranous colitis both in the process of taking the medication, and 2-3 weeks after the completion of therapy. In such a state, a person manifests leukocytosis , stomach ache.

If such symptoms develop, you need to stop the drug and take ion exchange resins. In severe colitis, it is necessary to replace the lost fluid, protein and electrolytes, prescribe oral Vancomycin or Metronidazole.

During treatment, you can not take drugs that inhibit intestinal motility.

If practiced long-term use funds by children, it is necessary to periodically monitor the formula and condition of the patient's liver. When you receive large doses medications need to control clindamycin's.

People who have been diagnosed with severe liver failure should be monitored for liver function.

Before you start taking the drug intravaginally, you need to exclude laboratory Chlamydia trachomatis, Trichomonas vaginalis, Neisseria gonorrhoeae , candida albicans, herpes simplex , which very often provoke the development of vulvovaginitis.

When using clindamycin intravaginally, an increased development of insensitive microorganisms, in particular yeast-like fungi, may occur.

Since there is a possibility of slight systemic absorption of the drug, diarrhea may develop against the background of the use of suppositories or creams. In this case, the remedy is canceled.

It should be noted that during the period of treatment it is necessary to refrain from sexual activity and not to use other drugs for intravaginal use.

The composition of this medicine contains components that can make rubber and latex products less durable. Therefore, it is not recommended to use condoms, diaphragms and other contraceptives from latex.

Does not affect the ability to drive a car or engage in other activities that require concentration.

Clindamycin analogs

Coincidence in the ATX code of the 4th level:

Structural analogs for the active ingredient are drugs , Zerkalin , Clindamycin phosphate , Klindatop , Klimitsin , Klindafer , Clindes , . The specialist should prescribe the optimal remedy.

children

The solution should not be used to treat children under 3 years of age, and capsules should not be used to treat children under 8 years of age. In the process of therapy, you must strictly adhere to the instructions.

During pregnancy and lactation

Clindamycin in solution and capsules is not prescribed.

You can use the remedy intravaginally for women in the second and third trimesters of pregnancy. In the first months of pregnancy, it is prescribed only if the expected benefit outweighs the potential harm when using a cream or suppositories. During lactation, you need to carefully weigh the expected benefits and potential harm. The drug can only be used under medical supervision.

Clindamycin tabletsWith a wide range activity against pathogenic bacteria. They help even in cases where other antibiotics are powerless. In addition, the drug can be used long time because it is relatively safe.

Clindamycin - tablets against microbes

The drug Clindamycin, produced in capsules for oral administration, is similar in its action to the antibiotic Lincomycin, but is much stronger in effectiveness.

Clindamycin tablets are dispensed in a pharmacy by prescription.

Produced by various manufacturers in Russia (Akrikhin, Vertex) and Serbia (Hemofarm).

In most cases, Clindamycin is prescribed 1 capsule 4 times a day for children over 15 years of age and adults. In case of severe complicated situations, the dose of the drug may be increased.

Scope of Clindamycin tablets

Clindamycin tablets are prescribed for inflammatory processes caused by pathogenic bacteria. These are diseases of the respiratory tract, urogenital system, ENT organs, as well as various diseases skin, including infected wounds, boils, felons, etc.

Clindamycin is also used to treat moderate to severe cases. The drug kills pathogenic bacteria, provoking the appearance of acne, and prevents their further reproduction.

For treatment acne it is enough to take 1 capsule of Clindamycin 2 times a day.

Contraindications and side effects of taking Clintomycin tablets

We should not forget that, despite the relative safety, the drug Clindamycin has contraindications and can cause side effects.

It is contraindicated to take Clintomycin capsules during pregnancy, lactation. They should also not be given to children, especially under the age of 2 years. In addition, the reason against prescribing tablets may be insufficient work of the kidneys, liver, disruption digestive system.

When taking Clindamycin tablets, nausea, vomiting, sometimes abdominal pain, disturbances in neuromuscular conduction, and some other side effects may occur.

Clindamycin, like other antibiotics, should never be taken with alcohol. The use of alcoholic beverages during treatment is fraught with significant decline, or complete neutralization of the action of the drug. In addition, when taking alcohol in the body, the recovery process is inhibited, and the risk of side effects increases significantly.

Price and analogues of Clindamycin tablets

The price of Clindamycil tablets in pharmacies of the Russian Federation is approximately 160-190 rubles per pack of 150MG capsules in the amount of 16 pieces.

Quantityanalogues of clindamycinnot too big. These include drugs: Clindafer, Klimitsin, Pulksipron, Dalacin C, Clindahexal.

Indirect analogues of Clindamycin include: Lincocin, Lincomycin and Ecolink.

Clindamycin: what drugs besides tablets are produced on its basis

Clindamycin, in addition to capsules for oral intake It is also available in other forms: injection solution, intravaginal cream, gel for the treatment of acne, suppositories for the treatment of urinary tract infections.

In severe forms of the disease, clindamycin is prescribed in the form of intramuscular or intravenous injections. As a rule, when acne the need for injections arises only when severe developments acne rash. A severe form is considered a disease in which there are more than 40 acne units on the patient's body.

Clindamycin solution for injection is available in ampoules of 2, 4 or 6 ml. The price of the package is in the range of 570-750 rubles.

In recipes traditional medicine the contents of clindamycin ampoules are used to create mashes for outdoor processing acne.

Cream Clindamycin

The main active ingredient in Clindamycin cream is clindamycin phosphate. It is used to treat bacterial vaginosis. Its main task is to suppress the formation of proteins in infected cells. In addition, the drug effectively eliminates itching and burning.

Instructions for clindamycin creamindicates that this drug is for intravenous use only vaginal application.

The instructions also state that, if necessary, Clindamycin cream can be used in the 2nd and 3rd trimesters of pregnancy. Since, according to experts, bad influence substances during this period on the fetus is unlikely.

Research on the use of the cream for over early dates pregnancy was not carried out. Therefore, it is considered appropriate to prescribe it in the 1st trimester of pregnancy only in cases where the benefit of therapy is significantly more important than the risk of inflicting potential risk fetus.

Available in aluminum tubes weighing 20 or 40 grams. The price of 1 tube is approximately 300 rubles.

It is worth noting that the cream has analogues: Vagitsin cream (price is about 300 rubles), Clindacin cream (costs about 400 rubles) and Dalacin cream (costs about 700 rubles).

Clindamycin - gel for the treatment of acne and acne

Clindamycin gelcontains, in addition to the main active component of clindamycin phosphate, several additional substances: allantoin, pripolen glycol, sodium hydroxide, water, etc.

Issuedin tubes of 15 grams. It has a homogeneous consistency and a specific smell. The drug is used to treat various kinds rashes. The gel is applied externally, directly on acne, several times a day. The recommended course of treatment is 14-30 days.

clindamycin for acneis very effective tool, as it fights directly with the cause of the occurrence inflammatory processes, the causative agent of which, most often, is a staphylococcal infection.

The price of one tube of Clindamycin gel is approximately 850-1000 rubles.

The antibiotic Clindamycin is also included in acne medications such as:

1. Gel Dalacin. Has a viscous texture white color or transparent, with a characteristic pungent odor. Recommended for use in the treatment of acne, purulent acne, staphyloderma, folliculitis. Produced in tubes of 30 grams. It costs in pharmacies of the Russian Federation in the range of 600-800 rubles.
2. Gel Klindovit. Recommended for the treatment of acne. Approved for release in pharmacies as an over-the-counter remedy. If necessary, treatment with the drug for a long period (up to 6 months) is allowed. Produced in tubes of 30 grams. The price of one tube is 300-400 rubles
3. Gel Klenzit-S. Contains two active ingredients: clindamycin and adapalene. Produced in India. Is combination drug for outdoor use. One 30 gram tube of gel costs about 800 rubles. More detailed description this drug you can.
4. Zerkalin solution. It is an effective means of combating acne with a lasting effect. In addition to Clindamycin, it contains a 96% ethanol solution, propylene glycol and water. Lotion Zerkalin after application penetrates deep into the comedones, and acts on pathogenic strains directly inside the focus of inflammation. In addition to the treatment of acne and comedones, is a good remedy acne prevention. It is recommended to start using the product when the first signs appear. skin diseases accompanied by rashes. The first results of acne treatment become noticeable at 4-6 weeks of use. In some cases, to achieve a lasting effect, the Zerkalin solution has to be used for a long time, up to 4-6 months, applying the product directly to acne 2 times a day. Produced in bottles of 30 ml. The price in Russian pharmacies is in the range of 300-400 rubles.

Clindamycin - suppositories

Clindamycin suppositories are prescribed to suppress infections in urinary tract. They are also listed as prophylactic in preparation for gynecological operations.

Solid fat is used as an additional component in the production of candles. Available in packs of 3 candles. The approximate price of one package of candles is 600 rubles.

The antibiotic Clindamycin is included in the preparations produced in various dosage forms: from tablets to gels and creams. But, if the gel is intended only to solve the problem of a rash, then drugs for oral administration and injection solutions solve a much wider range of problems.

You can learn more about the antibiotic Clindamycin from the video.

International name

Group affiliation

Dosage form

pharmachologic effect

An antibiotic of the lincosamide group. Has a wide spectrum of action, bacteriostatic, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. In relation to a number of gram-positive cocci, a bactericidal effect is possible. Active against Staphylococcus spp. (including Staphylococcus epidermidis producing penicillinase), Streptococcus spp. (excluding Enterococcus spp), Streptococcus pneumoniae, Corynebacterium diphtheriae, spore-forming and non-spore-forming anaerobes and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Mycoplasma spp., Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp., Actinomyces spp.

Most strains of Clostridium perfringens are sensitive to clindamycin, however, since other types of Clostridium (Clostridium sporogenes, Clostridium tertium) are resistant to clindamycin, an antibiogram is recommended for infections caused by Clostridium spp.

Clinically ineffective against Mycoplasma pneumoniae, Haemophilus influenzae, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

Cross-resistance exists between clindamycin and lincomycin. It is effective in the treatment of asymptomatic diphtheria carriage (a weekly course of therapy, orally).

Indications

Contraindications

Side effects

From the side nervous system: rarely - a violation of neuromuscular conduction.

From the digestive system: abdominal pain, nausea, diarrhea, vomiting, esophagitis, pseudomembranous enterocolitis, hepatotoxicity, hyperbilirubinemia, jaundice, dysbacteriosis.

On the part of the hematopoietic organs: leukopenia, neutropenia, agranulocytosis, thrombocytopenia.

From the side of the CCC: with a rapid on / in the introduction - a decrease in blood pressure, up to collapse.

Allergic reactions: rarely - maculopapular rash, urticaria, itching; in some cases - exfoliative and vesiculobullous dermatitis, eosinophilia, anaphylactoid reactions.

Local reactions: soreness (at the site of intramuscular injection), thrombophlebitis (at the site of intravenous injection).

Others: the development of superinfection.

Application and dosage

Inside, adults: 150 mg every 6 hours, with severe course infections single dose may be increased to 300-450 mg. Children: 8-25 mg / kg / day (depending on the severity of the infection), divided into 3-4 doses.

In the treatment of colpitis caused by Chlamydia trachomatis, 450 mg is prescribed 4 times a day for 10-14 days.

V / m or / in: adults - 300 mg 2 times a day. For moderate infections - 150-300 mg 2-4 times a day, for severe infections - 1.2-2.7 g / day for 2-4 injections. In life-threatening infections, the IV dose may be increased to 4.8 g/day.

Children are prescribed 10-40 mg / kg / day, divided into 3-4 doses.

For intravenous administration, dilute to obtain a concentration of not more than 6 mg / ml; the diluted solution is injected intravenously over 10-60 minutes.

Dilution scheme and duration of infusion: dose, solvent volume and duration of infusion (respectively): 300 mg - 50 ml - 10 minutes; 600 mg - 100 ml - 20 minutes, 900 mg - 150 ml - 30 minutes; 1200 mg - 200 ml - 45 min. It is not recommended to administer more than 1.2 g during 1 hour of infusion.

The solution is used within 24 hours from the moment of preparation. In the treatment of colitis caused by Clostridium difficile, it is immediately advisable to combine the appointment with vancomycin for 10 days, 500 mg - 2 g per day, divided into 3 or 4 equal doses.

Patients with severe renal / hepatic insufficiency require dose adjustment.

special instructions

Pseudomembranous colitis can appear both while taking clindamycin, and 2-3 weeks after stopping treatment (3-15% of cases); manifested by diarrhea, leukocytosis, fever, abdominal pain (sometimes accompanied by discharge with stool blood and mucus). If these phenomena occur in mild cases, it is sufficient to cancel treatment and use ion-exchange resins (colestyramine, colestipol), in severe cases compensation for the loss of fluid, electrolytes and protein is indicated, the appointment of vancomycin at a dose of 125-500 mg 4 times / day, or bacitracin at a dose of 25 thousand units 4 times / day for 7-10 days, or metronidazole 500 mg 3 times / day . Do not use drugs that inhibit intestinal motility.

The safety of the drug in newborns has not been established. The solution contains benzyl alcohol, which can lead to the development of choking syndrome in premature babies. According to "vital" indications, newborns are prescribed at a dose of 15-20 mg / kg / day in 3-4 doses, in some cases a lower dose may be effective.

With long-term therapy of children, periodic monitoring of the blood count and functional state liver.

When prescribing the drug in high doses, it is necessary to control the concentration of clindamycin in plasma.

Should not be prescribed for the treatment of meningitis.

Rapid intravenous administration may lead to the development acute insufficiency LV and decrease in blood pressure.

Interaction

Incompatible with solutions containing vitamin B complex, aminoglycosides, ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.

Shows antagonism with erythromycin and chloramphenicol.

Enhances the action of competitive muscle relaxants.

With simultaneous use with opioid (narcotic) analgesics, it is possible to increase the respiratory depression caused by them (up to apnea).

Simultaneous administration with antidiarrheal drugs that reduce gastrointestinal motility increases the risk of developing pseudomembranous colitis.

Aminoglycosides broaden the spectrum antimicrobial action; enhances (mutually) the effect of rifampicin.

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Genital diseases occur due to the development of various microorganisms in the vaginal cavity. There are many against them. medicines, each of which acts on a certain number of bacteria. The medicine Clindamycin also belongs to these.

How does it work? Who is shown? What are the restrictions before using it? - we will consider in more detail in this article.

pharmachologic effect

Antibacterial action

The drug Clindamycin has an antibacterial effect, which means that in essence it is an antibiotic.

The main direction in which the drug is used is the treatment of bacterial gardnerellosis.

The mechanism of action of the drug is to disrupt the secretion of proteins inside bacterial cells.

This contributes to the loss of their active ability and early death.

The highest activity of the drug is manifested against:

1. Mobiluncus;
2. Gardnerella vaginalis;
3. Bacteroids;
4. Peptostreptococcus;
5. Mycoplasmas hominis.

The drug is absolutely inactive against candida albicans, therefore it is not used for thrush. It also has no effect on Trichomonas vaginalis.

With the intravaginal use of the drug, its absorption into the whole body system occurs no more than in the amount of 4%.

Related videos:

Composition and form of release

The drug Clindamycin is created in the form of suppositories for intravaginal administration and cream.

Photos of drug release forms:

Vaginal cream Suppositories vaginal

The cream formulation also contains 100 mg of clindamycin phosphate. It is packaged in tubes of 40 g.

As auxiliary components are used:

1. 1/2 propylene glycol;
2. sodium benzoate;
3. Castor oil;
4. polyethylene oxide;
5. Emulsifier.

Also, the drug is produced under the name Clindamycin B Prolong in a cream of 6 or 20 g. In addition to 2 g of clindamycin, there is also 2 g of butoconazole nitrate.

Indications for use

Clindamycin is used to treat bacterial vaginosis.

healthy difference intimate zone from the zone of imbalance

Contraindications

A contraindication to the use of the drug Clindamycin is intolerance to the components of the drug and the 1st trimester of pregnancy.

Photo of the components of the drug:

Semi-synthetic glycerides
propylene glycol sodium benzoate
polyethylene oxide Emulsifier

Side effects

The use of the medicine may cause side effects.

Vaginal suppositories and cream can provoke allergy symptoms and local irritation. Sometimes cervicitis and vaginitis develop.

Thrush may occur after Clindamycin, as women say on the forums.

drug interaction

Clindamycin should not be used with aminoglycosides. The therapeutic effect of the latter is enhanced.

The medicine is completely incompatible with:

1. magnesium sulfate;
2. calcium gluconate;
3. barbiturates;
4. Derivatives of diphenylhydatoin.

Photo gallery medicines :

calcium gluconate

Efficiency active ingredient the drug Clindamycin enhances the effect of n-anticholinergics.

Alcohol compatibility

Vaginal suppositories and Clindamycin cream are antibiotics, therefore it is highly undesirable to combine with alcohol.

Dosage and overdose

An overdose of the drug is unlikely.

Instructions for use

The drug Clindamycin is used in gynecology. How to do it right for different forms release?

Shelf life and storage of the drug

The medicine is stored at room conditions for 3 year term.

special instructions

The drug in the form of a cream can be used by a man.

Medicine in candles during menstruation should not be used.

Clindamycin can be used during pregnancy, except during the first 3 months

Can it be applied to children? There is no information on the subject.

Price

The cost of the drug in candles is about 660 rubles, but the cream is 2 times cheaper. It costs about 360 rubles.

Useful video:

Terms of dispensing from pharmacies

Clindamycin cream is released according to the prescription sheet. You don't need it to buy candles.

Analogs substitutes

Analogues-synonyms of drugs include:

• Clindamycin available in capsules, solution and suppositories. Producer: "Hemofarm" (Serbia). There is an analogue Russian production firm "VERTEX".
• Dalacin create in capsules, suppositories, solution and cream. Manufacturer: "Pharmacy and Upjohn Company" (USA), "Pfizer" (France).
• Clindex produced in the form of candles.

Polygynax, Dalacin and Clindamin

Dalatsin and Clindamsin are one and the same, so there is no point in comparing.

Polygynax acts a little wider, as it is used for thrush.

Vaginal forms of all drugs should not be used during menstruation.

pharmachologic effect

An antibiotic of the lincosamide group for vaginal use. The mechanism of action of the drug is associated with a violation of intracellular protein synthesis in a microbial cell at the level of the 50S subunit of ribosomes.

Clindamycin has a wide spectrum of action, has a bacteriostatic effect, in more high concentrations against some microorganisms - bactericidal. Active against microorganisms that cause bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Bacteroides spp., Mycoplasma hominis, Peptostreptococcus spp. Trichomonas vaginalis and Candida albicans are not sensitive to clindamycin.

Pharmacokinetics

After a single intravaginal administration of 100 mg of clindamycin, an average of 4% of the administered dose is systemically absorbed. C max clindamycin in plasma is 20 ng / ml.

Indications

- bacterial vaginosis caused by microorganisms sensitive to the drug.

Dosing regimen

It is administered intravaginally using an applicator.

Side effect

Possible development allergic reactions, the appearance of irritation at the injection site, cervicitis, vaginitis, vulvovaginal candidiasis.

Contraindications for use

— hypersensitivity to clindamycin or lincomycin.

Use during pregnancy and lactation

Clinical studies on the use of clindamycin in women in the first trimester of pregnancy have not been conducted, so the use of the drug is possible only if the expected benefit to the mother outweighs the risk to the fetus. Application in II and III trimesters pregnancy is possible, since no adverse effects on the fetus have been found.

It is not known whether clindamycin is excreted in mother's milk when administered intravaginally, so the benefits of using the drug during the period should be compared. breastfeeding And possible risk for a baby.

Use in children

Overdose

With intravaginal use of the drug, an overdose has not been established.

drug interaction

An antagonistic interaction has been noted between clindamycin and erythromycin. Cross-resistance exists between clindamycin and lincomycin.

Terms of dispensing from pharmacies

On prescription.

Terms and conditions of storage

List B. In a dry, dark place, at a temperature not exceeding 20 ° C. Keep out of the reach of children. Shelf life - 3 years.

special instructions

At long-term use the drug is possible overgrowth microorganisms insensitive to it, especially fungi of the genus Candida.

Given the possibility of minimal systemic absorption of the drug (approximately 4%), the occurrence of diarrhea during the use of the drug cannot be ruled out. In this case, the drug should be discontinued.

The efficacy and safety of intravaginal clindamycin in children has not been established.