Disease of early aging in children. Early aging - causes, features and methods of prevention

What is progeria, what are its signs and effects? How is the disease diagnosed and what treatment is available today?

Hutchinson-Gilford Progeria Syndrome (HGS) is a rare, fatal genetic disorder characterized by sudden, accelerated aging in children, affecting one in 8 million children worldwide. The name of the syndrome comes from the Greek word and means "premature aging". Although there are various forms Progeria, the classic type of Hutchinson-Gilford Syndrome Progeria takes its name from the physicians who first described the disease, in 1886 Dr. Jonathan Hutchinson and in 1897 Dr. Hastings Guilford.

It is now known that SHGP is caused by a mutation in the LMNA (Lamin) gene. The LMNA gene produces the protein lamin, which holds the cell nucleus. Researchers believe that the defective lamin protein makes cell nuclei unstable. And it is this instability that starts the process premature aging.

Children with this syndrome appear healthy at birth, the first physical signs diseases can occur at the age of one and a half to two years. This cessation of growth, weight and hair loss, protruding veins, wrinkled skin - all this is accompanied by complications more characteristic of older people - joint stiffness, generalized atherosclerosis, osteoporosis, cardiovascular diseases, stroke. In children with this disease, remarkably similar appearance despite different ethnicity. Most often, children with progeria die of (heart disease) at an average age of thirteen (range from about 8 to 21 years).

There is also an "adult" progeria (Werner's syndrome), which begins in adolescence(15-20 years). The life expectancy of patients is reduced to 40-50 years. Most common causes deaths are myocardial infarction, stroke and malignant tumors. Exact reason scientists cannot establish the development of the disease.

Who is at risk?

Although progeria is genetic disease, in the classical sense of the Hutchinson-Gilford syndrome, but not hereditary, i.e. neither parent is either a carrier or affected. Each case is thought to be a sporadic (random) mutation that occurs either in the egg or sperm prior to conception.

The disease affects all races and both sexes equally. If a couple of parents have one child with SHGP, the chance that a second child will be born with the same condition is 1 in 4 to 8 million. There are other progeric syndromes that can be passed down from generation to generation, but not classic SHPS.

How is progeria diagnosed?

Now that this gene mutation has been identified, the Progeria Research Foundation has developed diagnostic testing programs. It is now possible to confirm specific genetic changes or mutations in a gene that lead to SHGP. After initial clinical assessment(appearance of the child and medical documentation), a blood sample is taken from the child for testing. The definitive scientific method for diagnosing children is currently being developed. This will result in more accurate and more early diagnosis , which will help ensure that children with this mutation are properly cared for.

What treatments are available for children with progeria?

The usual, at first glance, form psychological state- phobic anxiety, causes cell damage and leads to premature aging.

To date, only a few ways are available to optimize the quality of life of children with Progeria. Treatment includes ongoing care, cardiac care, special food and physical therapy.

Over the past few years, encouraging research data have been published that describe the potential drug treatment for children with progeria. Scientists believe that farnesyl transferase inhibitors (FTIs), originally developed to treat cancer, may reverse the structural abnormalities that cause progeria in children.

26 children took part in trials of the drug - this is a third of all known cases progeria. Children who took the drug showed a 50% increase in annual weight gain. The density also improved in children. bone tissue before normal level, and a 35% reduction in arterial stiffness, which is associated with high risk heart attack. The researchers emphasize that thanks to the new development, damage to blood vessels is not only reduced, but also partially restored over a period.

Mankind has not yet learned to deal with all ailments. Progeria, or premature aging syndrome, should also be attributed to the number of incurable diseases.

What is premature aging syndrome

For the first time, progeria was talked about relatively recently. This is not surprising, because the disease is extremely rare - 1 time in 4-8 million people. The disease occurs at the genetic level. The aging process is accelerated by approximately 8-10 times. There are no more than 350 examples of the development of progeria in the world.

The disease affects males more than females (1.2:1).

The disease is characterized strong delay in growth (manifested with early age), changes in the structure of the skin, the absence of hair and secondary sexual characteristics, as well as cachexia (exhaustion of the body). The internal organs are often not fully developed, and the person looks much older than his real age.

Progeria is a genetic disease that is manifested by underdevelopment and premature aging of the body.

The mental state of an individual suffering from progeria corresponds to biological age.

Progeria is not curable and is the cause of atherosclerosis ( chronic disease arteries), which eventually leads to heart attacks and strokes. The outcome of the pathology is fatal outcome.

Forms of the disease

Progeria is characterized by premature withering of the body or its underdevelopment. The disease involves:

• children's form (Hutchinson-Gilford syndrome);
• adult form (Werner's syndrome).

Progeria in children is congenital, but most often the first signs of the disease appear in the second or third year of life.

Progeria in adults is different. The disease can suddenly overtake an individual aged 14-18 years. The prognosis in this case is also unfavorable and leads to death.

Video: progeria, or young old people

Reasons for the development of progeria

The exact causes of progeria in this moment not detected. There is an assumption that the etiology of the development of the disease is directly related to the violation of metabolic processes in connective tissue. Fibroblasts begin to grow by cell division and the appearance of excess collagen with low association of glycosaminoglycans. Slow formation of fibroblasts is an indicator of the pathology of intercellular matter.

Causes of Progeria in Children

The reason for the development of progeria syndrome in children is changes in the LMNA gene. It is he who is responsible for encoding lamin A. We are talking about a human protein from which one of the layers of the cell nucleus is created.

Often, progeria is expressed sporadically (randomly). Sometimes the disease is observed in siblings (descendants from the same parents), especially in related marriages by blood. This fact indicates a potential autosomal recessive form of inheritance (manifested exclusively in homozygotes who received one recessive gene from each parent).

When studying the skin of carriers of the disease, cells were recorded in which the ability to repair damage in DNA was impaired, as well as to reproduce genetically homogeneous fibroblasts and change the depleted dermis. As a result subcutaneous tissue tends to disappear without a trace.

It was also recorded that the studied Hutchinson-Gilford syndrome is related to pathologies in carrier cells. The latter are simply unable to fully get rid of DNA compounds that cause chemical agents. When cells with the described syndrome were found, experts found that they were not characterized by full division.

There are also suggestions that childhood progeria belongs to an autosomal dominant mutation that occurs de novo, or without signs of inheritance. She was assigned to indirect evidence development of the disease, the basis of which included measurements of telomeres (end sections of chromosomes) in the owners of the syndrome, their close relatives and donors. In this case, an autosomal recessive form of inheritance is also seen. There is a theory that the process provokes a violation of DNA repair (the ability of cells to correct chemical damage, as well as gaps in molecules).

Causes of Progeria in Adults

Progeria in an adult organism is characterized by autosomal recessive inheritance with a mutational gene for ATP-dependent helicase or WRN. There is a hypothesis that in the unifying chain there are failures between DNA repair and metabolic processes in connective tissue.

Since this form of the disease is extremely rare, it remains only to guess what type of inheritance it has. It is similar to Cockayne syndrome (a rare neurodegenerative disorder that is marked by a lack of growth, disorders in the development of the central nervous system, premature aging and other symptoms) and manifests itself separate signs early aging.

Symptoms of early aging

The symptoms of progeria manifest themselves in a complex way. The disease can be recognized at an early stage, since its signs are pronounced.

Symptoms of early aging disease in children

At the birth of children who have a deadly progeria gene, indistinguishable from healthy babies. However, by the age of 1 year, certain symptoms of the disease manifest themselves. These include:

• lack of weight, growth retardation;
• lack of hair on the body, including on the face;
• lack of subcutaneous fat reserves;
• insufficient tone in the skin, as a result of which it sags and becomes overgrown with wrinkles;
• bluish skin tone;
• increased pigmentation;
• strongly manifested veins in the head;
• disproportionate development of the bones of the skull, a small lower jaw, bulging eyes, protruding ear shells, a hooked nose. For a child with progeria, a "bird" grimace is characteristic. It is the described list of peculiar characteristics that makes children outwardly similar to older people;
• late eruption of teeth, which a short time lose their healthy appearance;
• shrill as well as high voice;
• pear-shaped chest, small collarbones, tight knee joints, as well as the elbow, which, due to insufficient mobility, force the patient to take the position of the "rider";
• protruding or protruding yellow nails;
• sclerotic formations or seals on the skin of the buttocks, thighs and lower abdomen.

When little patient, suffering from progeria, turns 5 years old, inexorable processes of atherosclerosis formation begin to occur in his body, in which the aorta, mesenteric, and also coronary arteries. Against the background of the described failures, heart murmurs and hypertrophy (a significant increase in the mass and volume of the organ) appear in the left ventricle. The combined impact of these serious violations in the body is a key reason for the low life expectancy of carriers of the syndrome. The underlying factor that provokes the rapid death of children with progeria is myocardial infarction or ischemic stroke.

Symptoms of early aging in adults

A carrier of progeria begins to quickly lose kilograms, stun in growth, turn gray and soon go bald. The patient's skin becomes thin, loses its healthy shade. Under the surface of the epidermis are clearly visible blood vessels and subcutaneous fat. The muscles in this disease atrophy almost in full, as a result of which the legs and arms look unnecessarily emaciated.

In patients who have passed age indicator at 30, both eyes are destroyed by cataracts (clouding of the lens), the voice becomes noticeably weaker, the skin over the bone tissue loses its softness, and then becomes covered ulcerative lesions. Carriers of the progeria syndrome usually resemble each other in appearance. They are distinguished:

• small growth;
• moon-shaped type of face;
• "bird" nose;
• thin lips;
• strongly prominent chin;
• a strong, knocked-down body and dry, thin limbs, which are disfigured by generously manifesting pigmentation.

The disease is distinguished by arrogance and interferes with the work of all body systems:

• the activity of sweat and sebaceous glands is disrupted;
• distorted normal function of cardio-vascular system;
• calcification occurs.
• osteoporosis appears (decrease in bone density) and erosive osteoarthritis (irreversible processes in the joints).

Unlike the child form, the adult form also has a detrimental effect on mental abilities.

Approximately 10% of patients by the age of 40 come into contact with such serious ailments like a sarcoma malignancy in tissues), breast cancer, as well as astrocytoma (brain tumor) and melanoma (skin cancer). Oncology progresses based on high sugar in the blood and malfunctioning functions parathyroid glands. Key reasons mortality in adults with progeria are most often cancers or cardiovascular disorders.

Diagnostics

The external signs of the manifestation of the disease are so obvious and vivid that the syndrome is diagnosed based on the clinical picture.

The disease can be detected even before the birth of the child. This became possible thanks to the found progeria gene. However, since the disease is not transmitted through generations (this is a sporadic or single mutation), the likelihood that two children with this rare disease will be born within the same family is extremely small. After the progeria gene was discovered, the detection of the syndrome became much faster and more accurate.

At present, changes at the gene level are identifiable. Special programs, or electronic diagnostic tests, have been created. At the moment, it is quite realistic to prove and substantiate individual mutational formations in the gene, which subsequently lead to progeria.

Science is developing rapidly, and scientists are already working on the final scientific method for diagnosing progeria in children. The described development will contribute to even earlier, as well as accurate diagnosis. Today, in medical institutions, children with such a diagnosis are examined only externally, and then they take tests and a blood sample for testing.

If symptoms of progeria are detected, it is urgent to seek advice from an endocrinologist and undergo a comprehensive examination.

Progeria treatment

Up to this day effective method there is no cure for progeria. Therapy is characterized by a symptomatic line, with the prevention of consequences and complications following the progress of atherosclerosis, diabetes mellitus and ulcer formations. For anabolic effect (acceleration of the process of cell renewal) is prescribed growth hormone, which is designed to increase the mass, as well as the length of the body in patients. The therapeutic course is carried out by several specialists at once, such as an endocrinologist, cardiologist, internist, oncologist, as well as others, based on the symptoms prevailing at a particular moment.

In 2006, scientists from America recorded clear progress in the fight against progeria as an incurable disease. The researchers introduced into the culture of mutating fibroblasts a farnesyl transferase inhibitor (a substance that suppresses or delays the course of physiological or physico-chemical processes), which had previously been tested on cancer patients. As a result of the procedure, the mutation cells acquired their usual shape. The carriers of the disease tolerated the created drug well, so there is hope that in the near future it will be possible to use the remedy in practice. Thus, it will be possible to exclude progeria at an early age. The effectiveness of Lonafarnib (a farnesyl transferase inhibitor) lies in the increase in the number subcutaneous fat in total mass body, as well as bone mineralization. As a result, it turns out to reduce the number of injuries to a minimum.

There is an opinion that they can help in curing the disease similar means just like fighting cancer. But these are only assumptions and hypotheses, not confirmed by facts.

Therapy of patients today is reduced to:

• providing ongoing continuous care;
• special diet;
• cardiac care;
• physical support.

In progeria, treatment is exclusively supportive and focuses on correcting changes that occur in the tissues or organs of the patient. The methods used are not always effective. However, doctors do their best. Patients are under continuous supervision by medical professionals.

Only by monitoring the function of the cardiovascular system is it possible to timely diagnose the development of complications and prevent their progress. All treatment methods are focused around a single goal - to stop the disease and not give it a chance to worsen, as well as to alleviate the general condition of the carrier of the syndrome, as far as the potential of modern medicine allows.

Treatment may include:

• the use of aspirin in the minimum dosage, which can reduce the risk of developing a heart attack or stroke;
• the use of other medicines that are prescribed to the patient privately based on the present symptoms and his well-being. For example, drugs from the statin group reduce the amount of cholesterol in the blood, and anticoagulants resist the formation of blood clots. Often a hormone is used that can increase growth and weight;
• the use of physical therapy or procedures designed to develop joints that are difficult to flex, thereby allowing the patient to maintain activity;
• elimination of milk teeth. A peculiar feature of the disease contributes to the premature appearance of molars in children, while milk teeth must be removed on time.

Based on the fact that progeria is genetic or random, then preventive measures as such, there are none.

Treatment prognosis

The prognosis for carriers of the progeria syndrome is poor. Averaged indicators say that patients most often live only up to 13 years, subsequently dying from hemorrhages or heart attacks, malignant neoplasms or atherosclerotic complications.

Progeria is incurable. Therapy is in development. There is no definitive proof of a cure yet. However, medicine is developing rapidly, so it is likely that patients with progeria will have a chance for a normal and long life.

All people age. According to scientists, if it were not for the destructive effects of the external environment and our addiction to pleasures that are harmful to the body, we would live up to 130, or even up to 150 years. And 16 years ago, on August 29, 2001, scientists even announced that they had found a gene for longevity. So, perhaps, in the near future we will be able to live the entire life span allotted to us by nature. But while we grow old and die in the vast majority before 80-90 years. And some diseases reduce this already not so long period at times. And the most "deadly" among them, in the truest sense of the word, is progeria. MedAboutMe found out what it's like to grow old in a decade and a half to two decades.

Aging is natural process characteristic of every living organism on earth. All available theories on the topic "Why do people age?" can be divided into two large groups. Supporters of one of them argue that aging was conceived by nature for the further evolution of species and society. Others are sure that there are no global ideas here - just damage at the gene and cellular level accumulates over time, which leads to wear and tear of the body.

One way or another, but really in the course of a person's life in his cells and tissues, the results of internal failures and errors accumulate, as well as the consequences external influences. Key factors in aging include:

• Impact active forms oxygen (ROS), which, of course, our body needs, but not always and not everywhere.
• DNA mutations somatic cells(i.e. body cells). The genome is not a structure frozen in time and space. It is a living and subject to change design.
• Accumulation of damaged proteins that are side effect actions of ROS or failures in metabolic processes.
• Shortening of telomeres - the terminal sections of chromosomes. True, in recent times scientists began to doubt that aging is related to telomeres, but so far this theory is still popular.

Progeria, which will be discussed in this article, it is not aging - in the sense in which science understands it when it talks about life expectancy, wear and tear of the body, etc. This disease looks like aging, although in fact it is a serious genetic disease associated with a violation production of certain proteins.

Progeria - diseases of children and adults

The Englishman Jonathan Hutchinson in 1886 first described a 6-year-old child in whom he observed skin atrophy. Name unusual illness(from the Greek word "progeros" - aged ahead of time) was given to her in 1897 by Dr. Gilford, who studied and described the nuances of the disease. In 1904, Dr. Werner published a description of adult progeria - using the example of four brothers and sisters who suffered from cataracts and scleroderma at once.

It is believed that F. Scott Fitzgerald wrote his story "The Curious Case of Benjamin Button" in 1922 under the influence of information about patients with progeria. In 2008, Brad Pitt played the protagonist of the book in the film Misterious story Benjamin Button.

There are two types of progeria:

• A disease affecting children is Hutchinson-Gilford syndrome.

This is a rare pathology. It occurs in 1 child out of several million. It is believed that in the world today there are no more than a hundred people suffering from childhood progeria. True, scientists suggest that we can talk about about 150 more undiagnosed cases.

• A disease that affects adults is Werner's syndrome.

It is too rare disease, but not as much as children's progeria. People with Werner's syndrome are born in 1 case out of 100 thousand. In Japan - a little more often: 1 case per 20-40 thousand newborns. In total, a little less than 1.5 thousand such patients are known in the world.

Childhood progeria is only indirectly related to true aging. This is a disease from the group of laminopathies - diseases that develop against the background of a problem with the production of lamin A protein. If it is not enough, or the body produces the “wrong” lamin A, then one of a whole list of diseases develops, which includes Hutchinson-Gilford syndrome.

The cause of childhood progeria is a mutation in the LMNA gene, which is located on the 1st chromosome. This gene encodes the compound prelamin A, which produces the protein lamin A, which forms thin plate Lamina that covers the inner membrane of the nucleus. It is necessary for anchoring all kinds of molecules and internal structures kernels. If lamin A is not enough, inner frame cell nuclei cannot be built, it cannot maintain stability, which leads to accelerated destruction of cells and the whole organism. In addition, lamin A plays a key role in cell division. It regulates the breakdown and restoration of the cell nucleus. It is not difficult to imagine what can happen if this protein is not enough or it is not what it should be. Mutation of the LMNA gene leads to the formation of the "wrong" protein - progerin. It is he who causes the accelerated "aging" of children.

According to the latest data, the mutation occurs on early stages development of the embryo and is almost never transmitted from parent to child.

A few years ago, scientists discovered that healthy cells also produce progerin, but in much smaller amounts than in Hutchinson-Gilford syndrome. Moreover, it turned out that with age, progerin in normal cells becomes more. And this is the only thing that really links childhood progeria and the aging process.

Adult progeria is the result of another mutation, in the WRN gene. This gene encodes a protein necessary for maintaining chromosomes in stable condition, as well as involved in the processes of cell division. In the presence of a mutation in the WRN gene, the structure of chromosomes is constantly changing. The frequency of spontaneous mutations increases 10 times, while the ability of cells to divide falls 3-5 times compared with healthy cells. Telomere length also decreases. And these processes are already really close to the aging that we have in mind when looking at older people on a bench.

It can develop at the genetic level. This is a progeria disease. Also, factors that are not related to genes can affect the occurrence of the condition.

Progeria

Premature aging syndrome is extremely rare. This fatal character develops only in children. Premature aging syndrome is detected in approximately one child in four to eight million newborns. The likelihood of developing the disease is the same in both girls and boys.

Newborn babies who are diagnosed with premature aging syndrome look quite healthy. However, when they reach the age of ten to twenty-four months, they show symptoms of progeria.

Among the main signs of the disease, it should be noted:

A sharp slowdown in growth;

Baldness;

Weight loss;

Stiffness in the joints;

Generalized atherosclerosis.

Despite the fact that premature aging syndrome can be detected in children belonging to different ethnic groups, the patients are surprisingly similar. As a rule, patients rarely live more than twenty years. Average duration the life of such patients is about thirteen years.

Children with progeria are genetically susceptible to premature progressive heart disease. In almost all cases, death occurs precisely because of these diseases. Among the complications of cardiovascular origin, stroke, hypertension, angina pectoris are detected.

Premature aging of non-genetic origin

With natural aging, corresponding to old age, almost everyone manages to put up with it. However, when premature aging sets in, the condition becomes a serious problem. Women react very painfully to the development of this condition.

Under the influence of certain factors, first appears premature then internal systems and organs. As a result, often the actual age of many people is much less than the biological age.

early aging skin appears in different ways. As a rule, the cover becomes wrinkled, dry, swelling of the lower and corners of the mouth appears.

The main reasons for the development of the condition, first of all, include lifestyle, diseases, climate, nutrition, as well as the condition environment.

Among the types of skin aging, photoaging is also distinguished. The condition develops as a result of insufficient moisture and an excess of sun exposure. At the same time, it should be noted that it is impossible to replenish the concentration of moisture in the skin simply by consuming a large amount of liquid. For it, it is necessary to use special means, in the properties of which - the ability to retain water molecules.

One of the destructive factors is smoking. As you know, it contributes to vasoconstriction, depriving the body of oxygen. As a result, they do not reach the upper skin layer. nutrients, it begins to break down, succumbing to the effects of free radicals.

The penetration of toxins can paralyze important features organism, which, in turn, will provoke a lack necessary products in skin.

Great importance experts give vitamins. It should be remembered that the correct balanced diet containing healthy foods.

Psycho-emotional factors also influence the condition of the skin. In the conditions of modern, often stressful, life, the body is depleted very quickly. In this case, it is necessary to pay attention to the daily routine, control working time and rest periods.

Thus, it is possible to prevent early aging not only of the skin, but of the whole organism.

Progeria is rare and incurable disease, with a mechanism not exactly known, formed due to genetic damage. As a result of changes in genes, children are born, progressively and quickly begin to turn into old people. With this disease, the life expectancy of all cells of the body and the whole organism as a whole is sharply reduced. Progeria is dangerous not only in children, but also in adults, the disease can progress from the newborn or from adulthood.
A variant of progeria in infants is called Gilford Hutchinson's syndrome, in adulthood it is billed as Werner's syndrome. In fact, this is premature aging of the body.

The reasons

Progeria is an incurable, serious pathology in which premature aging of the child's body occurs, sometimes starting from the prenatal period. This is a genetic breakdown in one of the sections of the genes that are responsible in the body for the aging process of cells and their death. AT normal conditions the aging program starts slowly and in late dates, after maturation of the organism. With progeria, this process is accelerated hundreds of times. Children of both sexes are subject to it, in a short time they turn into old people, although in fact they have absolutely childhood. Occasionally, progreria occurs in adolescents and adults, but this is even rarer.

The formation of progeria at an early age is called Gilford-Hutchinson syndrome, usually boys are somewhat more often affected, on average, the age of children is up to 10-13 years. AT rare cases at special care with progeria, children live up to 18-20 years. The disease cannot be stopped, it progresses and inexorably leads to death.

The mechanism by which the disease develops has not been fully elucidated. big share probability found that the mutation is supplied by a special gene - lamin. This gene and the protein it produces are responsible for the process of proper cell division. If there is a failure in the region of this gene, the cells lose their resistance harmful influences environment and the body starts the aging program. Although this is a genetic disease, it is not inherited, but familial cases can occur - the birth of several children with progeria in a couple.

Symptoms

The manifestations of the disease are quite obvious. Children from a very early age begin to lag behind their peers in terms of physical development. In addition, their body wears out too quickly, becoming what a person usually reaches after 70-90 years. The structure of the skin is disturbed, there are no signs of puberty, and the internal organs are sharply underdeveloped. Children outwardly look like old men, have childish intelligence and are emotionally suffering from similar disease. Them mental condition is not disturbed in any way, they develop in terms of the psyche according to age.

The body has the proportions of a child, while the areas of cartilage where the bone grows grow rapidly, making the skeleton similar to that of an adult. The child's body suffers from such adult pathologies as diabetes, atherosclerosis, ischemic disease hearts. Dies usually from senile pathologies.

The main manifestations of progreria:

• At birth, the child practically does not differ from healthy children.
• In the first year of life, height and weight gains lag behind sharply, children have very low height and weight.
• They have a pronounced lack of body fat, and skin tone is sharply reduced, it is wrinkled and dry.
• Hair on the head, eyebrows and eyelashes, all over the body does not grow or falls out quickly.
• The skin has a strong pigmentation like that of the elderly and a bluish tint.
• The skull and bones of the face are disproportionate, the eyes are bulging, lower jaw very small, protruding ears, hooked nose.
• The teeth erupt late and fall out quickly, the voice is high pitched, shrill and hoarse.
• The chest is shaped like a pear, the collarbones and limbs are small, the joints move tightly.

By the age of five, the walls of blood vessels are sharply affected by atherosclerosis in children, sclero-like formations form on the skin, especially on the buttocks, thighs and abdomen. suffer large vessels chest and abdomen, the structure and work of the heart changes.

Diagnosis of progeria in children

The basis of diagnosis is typical clinical manifestations. If necessary, medical genetic counseling and the identification of an abnormal gene are carried out. It also shows the examination and identification of complications of pathology.

Complications

The main complications of progeria are the wear and tear of all internal organs, changes in the heart, the formation of strokes and heart attacks, diabetes and atherosclerosis. Patients die from these diseases after the age of 10 years. The prognosis for pathology is unfavorable, cases of cure are unknown.

Treatment

What can you do

There is no cure for this pathology; you should not spend money on empty promises to cure the baby. So far, there is no way to correct gene defects. shown complete care and maximum social adaptation, good nutrition and baby care. No means traditional medicine from progeria is also not available.

What does a doctor do

Medical treatment is also carried out only for the purpose of maintaining general condition health and prevention of complications. Prophylactic anticoagulants and cholesterol-lowering drugs are shown. Growth hormone can be used to help in the accumulation of weight and growth of children, and physiotherapy is also indicated to improve the functioning of the joints and internal organs.

In children with progeria, milk teeth are removed, as permanent teeth erupt early.

Prevention

Prevention methods have not been developed, since the pathology is genetic, and it is extremely difficult to influence it. It is worth planning a pregnancy against the background full health, but it is impossible to fully predict the likelihood of having children with progeria.

You will also find out what can be dangerous untimely treatment progeria disease in children, and why it is so important to avoid the consequences. All about how to prevent progeria in children and prevent complications.

And caring parents will find on the pages of the service full information about the symptoms of progeria in children. How do the signs of the disease in children at 1.2 and 3 years old differ from the manifestations of the disease in children at 4, 5, 6 and 7 years old? What is the best way to treat progeria in children?

Take care of the health of your loved ones and be in good shape!