Staphylococcus aureus in dogs treatment. Staphylococcal bacteriophage - a real alternative to antibiotics or a drug with dubious effectiveness

Formula, chemical name: Staphylococcal bacteriophage is a filtrate of staphylococcal phagolysate.
Pharmacological group: immunotropic drugs/vaccines, sera, phages and toxoids.
Pharmachologic effect: immunostimulating.

Pharmacological properties

Staphylococcal bacteriophage is able to lyse staphylococci.

Indications

Purulent-inflammatory diseases of the lungs, respiratory tract and ENT organs (sinusitis, tonsillitis, otitis media, pharyngitis, tracheitis, laryngitis, bronchitis, pleurisy, pneumonia) and gastrointestinal tract(gastroenterocolitis, intestinal dysbacteriosis, cholecystitis); purulent-inflammatory diseases infants and newborns (omphalitis, gastroenterocolitis, pyoderma, sepsis, conjunctivitis); surgical infections(mastitis, purulent wounds, abscess, burn, phlegmon, felon, carbuncle, bursitis, paraproctitis, hidradenitis, osteomyelitis); generalized septic diseases; urogenital infections (colpitis, urethritis, endometritis, cystitis, salpingoophoritis, pyelonephritis); prophylaxis in the form of treatment of freshly infected and postoperative wounds, prevention by epidemic indications nosocomial infections.

Method of application of bacteriophage staphylococcal and dose

Staphylococcal bacteriophage is taken orally. With intestinal dysbacteriosis, diseases internal organs, enterocolitis - inside 1 hour before meals 3 times a day; at one time: patients up to six months - 5 ml, patients 0.5 - 1 year old - 10 ml, patients 1 - 3 years old - 15 ml, patients 3 - 8 years old - 20 ml, patients over 8 years old - 30 ml.
Rectally in the form of enemas 1 time per day along with twice oral use; at one time: patients up to six months - 10 ml, patients 0.5 - 1 year old - 20 ml, patients 1 - 3 years old - 30 ml, patients 3 - 8 years old - 40 ml, patients over 8 years old - 50 ml.
Locally: in the treatment of purulent-inflammatory diseases with localized lesions, for 1-3 weeks. If antiseptics were used to treat the cavity of purulent foci before using the bacteriophage, then they must be thoroughly washed with a sterile 0.9% sodium chloride solution. Purulent wounds: in the form of applications, irrigation, introduction through drainage, dressings, at least 1 time per day. After opening the abscesses and removing their contents, the drug is administered in an amount less than the removed contents of the cavity. 20-200 ml is injected into the drained cavities once a day.
Introduction into cavities (including articular, pleural and other limited cavities): up to 100 ml of the drug, after which capillary drainage is left, through which the drug is re-injected for several days.
Osteomyelitis: the drug is injected into the wound through drainage, 10-20 ml of turunda. Purulent-inflammatory diseases in gynecology, the drug is injected into the uterine or vaginal cavity once a day at a dose of 5-10 ml.
Cystitis, urethritis, pyelonephritis: administered through a nephrostomy or cystostomy into the renal pelvis, 5-7 ml and into bladder 20 - 50 ml.
Purulent-inflammatory diseases in ENT practice for washing, rinsing, the introduction of moistened turundas (with further leaving them for 1 hour), instillation, the drug is administered 1-3 times a day at a dose of 2-10 ml.
Children under six months: neonatal enterocolitis (including premature babies), sepsis 2-3 times a day in the form of high enemas (through a catheter or vent tube). In the absence of regurgitation and vomiting, the drug, mixing with breast milk are used internally. It is possible to combine oral and rectal use of the drug. The duration of therapy is 5-15 days, with a recurrent course of the disease, repeated courses of therapy are possible. Prevention of enterocolitis and sepsis at the risk of nosocomial infection in newborns or intrauterine infection, the drug is administered in the form of enemas or suppositories 2 times a day for 5 to 7 days. Pyoderma, omphalitis, infected wounds - daily 2 times a day in the form of an application (moisten a gauze with bacteriophage and apply to the affected area of ​​the skin or umbilical wound).

The use of a staphylococcal bacteriophage does not exclude the use of other drugs (including antibiotics, anti-inflammatory drugs). One of important conditions successful phage therapy is the preliminary determination of phage sensitivity.

Contraindications for use

Hypersensitivity.

Application restrictions

Produced in the form of a solution, used for oral administration through the mouth, for rectal administration, local and external use in the form of applications, irrigation; is introduced into the nasal cavity, nasal sinuses, into the wound cavity, into drained cavities, into the cavity of the vagina, uterus (see the rules for use).

The composition of the drug includes: the active substance is a sterile filtrate of phagolysates of bacteria of the genus Staphylococcus and excipients are preservatives 8-hydroxyquinoline sulfate or hydroxyquinoline sulfate monohydrate. Available in bottles of 20 or 100 milliliters. One pack contains 4 or 8 vials of 20 ml or one vial of 100 ml. It is necessary to store and transport the bacteriophage at a temperature of 2 to 8 C o in a place protected from light rays.

The drug is suitable for use within two years from the date of issue, subject to the appropriate storage rules. But if, when buying a drug, the integrity of the vials or labeling is violated, the solution becomes cloudy or a precipitate is observed, the expiration date has expired, then such a drug is not suitable for use.

Staphylococcal bacteriophage - it is a clear liquid without sediment, yellow tint varying degrees intensity. Possesses biological properties cause specific lysis (dissolves the shell) of strains of Staphylococcus bacteria.

bacteriophage does not have side effects, but may cause sensitivity to any components of the solution or intolerance. In such cases, the bacteriophage is contraindicated.

Bacteriophage can be used in combination with other pharmaceuticals, including antibiotics. An overdose of the drug has not been identified.

Staphylococcal bacteriophage is used for the treatment and prevention various infections bacterial nature. It can be both purulent-inflammatory and enteral diseases, but the condition for use is the same - the presence of bacteria of the genus Staphylococcus, the strains of which are previously detected during bakposev.

Diseases that have indications for the use of staphylococcal bacteriophage:

• Diseases of the oral cavity, throat, nose, nasopharynx, ear, respiratory tract (sinusitis, tonsillitis, pharyngitis, tonsillitis, bronchitis, laryngitis, pneumonia, pleurisy, tracheitis);
• Infections after surgical interventions (festering wounds, burns, phlegmon, abscess, carbuncle, furuncle, panaritium, osteomyelitis, mastitis, paraproctitis, bursitis, hydroadenitis);
• Urogenital infections (cystitis, colpitis, vaginosis, urethritis, pyelonephritis, salpingo-oophoritis, endometritis);
• Enteroinfections (gastroenteritis, gastroenterocolitis, cholecystitis, intestinal dysbacteriosis);
• Septic diseases of a generalized nature;
• Pyoinflammatory diseases in newborns (pyoderma, omphalitis, sepsis, conjunctivitis, blepharitis, gastroenterocolitis, and others);
• Many other diseases caused by the bacterium staphylococcus aureus.
• When especially severe manifestations staph infection drug is used in complex therapy along with other antibacterial agents.
• For the prevention of infection of wounds, the drug is used in the case of treatment of freshly infected and postoperative wounds.
• To prevent nosocomial infections, the drug is used as part of epidemiological measures.

Doses and rules of admission:

During pregnancy and lactation bacteriophage is used in doses recommended by the doctor.

In children under 6 months: (at one time) orally (through the mouth) - 5 ml, rectally - 5-10 ml. In the event of sepsis, enterocolitis in children of this age (this also applies to premature babies), the bacteriophage is administered using high enemas - through a catheter or gas outlet tube per day 2-3 times at a dose of 5-10 ml. If there is no regurgitation or vomiting, you can administer the drug orally, mixing with breast milk. Possible combination of rectal and oral intake bacteriophage. Usually the course of treatment lasts from 5 to 15 days. In case of recurrence of the disease, there is an opportunity for repeated courses of treatment.

In the prevention of sepsis and enterocolitis with intrauterine infection or in case of a threat of nosocomial infection in newborns, the drug is used by enemas 2 times a day for 5-7 days.

For the treatment of omphalitis, pyoderma, infected wounds ok in children of this age, the drug is used daily in the form of applications twice a day. In this case, a sterile gauze napkin is moistened in a bacteriophage solution and applied to the umbilical wound or other affected areas of the skin.

For children aged 6 to 12 months:(at one time) orally - 10 ml, rectally - 10-20 ml

In children aged 1 to 3 years:(at one time) orally - 15 ml, rectally - 20-30 ml

For children 3 to 8 years of age:(at one time) orally - 15-20 ml, rectally - 30-40 ml

From 8 years old and adults:(at one time) orally - 20-30 ml, rectally - 40-50 ml

In the treatment of purulent inflammatory diseases with limited lesions are carried out simultaneously local treatment and taking the drug inside 2-3 times on an empty stomach one hour before meals, starting from the first day of illness and for 7-20 days (according to indications).

If the wound was treated with chemical antiseptics before using the bacteriophage solution, then the wound is thoroughly washed with a sterile 0.9% sodium chloride solution before using the bacteriophage.

Depending on the localization of foci of infection, staphylococcal bacteriophage is used:

By irrigation, rinsing, lotions, plugging in volumes up to 200 ml, depending on the size of the lesion. With an abscess, after removing the pus, a bacteriophage is injected into the wound by puncture in an amount smaller than the volume of the removed purulent contents. With osteomyelitis after surgical intervention bacteriophage solution with a volume of 10-20 ml is poured into the wound.

With the introduction of a bacteriophage into the pleural, articular and other limited cavities a volume of up to 100 ml is used, after which capillary drainage is left, through which a bacteriophage is introduced for the required number of days.

In case of cystitis, urethritis, pyelonephritis the drug is taken orally orally. When draining the cavity of the renal pelvis or bladder, the bacteriophage solution is administered through a nephrostomy or cystostomy up to two times a day, inclusive, in doses of 5 to 7 ml into the renal pelvis, from 20 to 50 ml into the bladder.

• 50, or 100 ml of such a solution in a vial - one vial in a cardboard box.
• 20 ml of this solution in a bottle - four bottles in a cardboard box.
• 25 ml of this solution in an aerosol can - one package in a carton.
• 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
• 10 candles per pack, one pack per carton.
• 10, 25 and 50 tablets per pack, one pack per carton.

pharmachologic effect

Antibacterial action.

Pharmacodynamics and pharmacokinetics

What is a bacteriophage?

This drug is relatively new on the drug market, and many patients have a natural question: "Bacteriophage - what is it?"

Bacteriophages are viral particles that only kill certain types pathogenic bacteria. On their basis, appropriate preparations are created. The discovery of drugs belongs to the Canadian scientist Felix D'Herelle.

The structure of bacteriophages

A typical bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with inactive transcriptase surrounded by a shell of protein or lipoprotein called capsid .

Reproduction of bacteriophages

As with conventional viruses, the reproduction cycle in lytic bacteriophages can be roughly divided into phage adsorption on the cell wall, DNA introduction, phage reproduction, and evacuation of daughter populations from the cell.

Attachment of a phage to a bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, the acidity of the medium, the presence of cations, and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is cleaved lysozyme. Simultaneously, calcium ions are released, activating ATPase - this causes the contraction of the sheath and the introduction of the tail shaft into the cage. The virus DNA is then injected into the cytoplasm. Having penetrated into the bacterium, the phage DNA takes control of the cell's genetic apparatus, carrying out the reproductive cycle of the phage.

First of all, there is a synthesis of enzymes necessary for the formation of copies of phage DNA ( DNA polymerases, thymidylate synthetase, kinases ). It takes 5-7 minutes from the moment of infection. RNA polymerase cells convert viral DNA into mitochondrial RNA, which is translated by ribosomes into "early" proteins. "Early" proteins are mainly viral RNA polymerase and proteins that limit bacterial gene expression. Viral RNA polymerase produces transcription of the so-called "late" proteins necessary for the assembly of new phage particles.

Reproduction of nucleic acids occurs due to the activity synthesized DNA polymerases virus. By the end of the cycle, the phage components are combined into a mature virion.

Evacuation of bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes progeny DNA. Specialized regions in the DNA of the virus induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail, forming a daughter phage. After the release of the offspring, the host cell is destroyed, releasing a new population.

An alternative to cell destruction can be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes plasmid . As a result, the virus genome replicates along with the host's DNA.

Types of Bacteriophages

The use of bacteriophages causes them clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

• bacteriophages for therapy intestinal infections : dysenteric, polyvalent, salmonella ABCDE-groups, typhoid, coliproteic, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
• bacteriophages for therapy purulent-septic lesions : Klebsiella pneumonia, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of purulent-septic infections).

The use of bacteriophage preparations in medicine is becoming more widespread due to the increasing cases of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to use this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus aureus:

• urogenital infections ( , salpingoophoritis, );
• infections in surgery (burns, suppuration of wounds, , boils, phlegmon, felons, paraproctitis, );
• diseases of the throat, ear, nose, respiratory organs (, sinuses, , pleurisy );
• infections digestive tract (gastroenterocolitis ), , ;
• prevention of postoperative septic complications;
• prevention of hospital infections.

Contraindications

Contraindications for use this tool missing.

Side effects

Undesirable reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation.

Instructions for Staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The multiplicity of injections and their size is set using the definition clinical form disease, the nature of the infectious focus and standard recommendations. Average duration treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for the use of staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be applied topically in the form of lotions, irrigation or plugging in a volume of up to 200 ml, taking into account the size of the affected area. Also for local application serves as an ointment.

Therapy purulent-inflammatory limited lesions expedient to be carried out both locally and by oral route within 1-4 weeks.

At purulent-inflammatory lesions of the throat, ear or nose the drug is used for rinsing, instillation, washing and administration of moistened turundas 2-10 ml up to three times a day.

At carbuncles and boils liquid bacteriophage is injected directly into the focus or around it, daily, 0.5-2 ml. In total, up to 5 injections are made for the course of treatment.

Treatment chronic osteomyelitis carried out by infusion of the drug into the wound immediately after surgical treatment.

At abscesses bacteriophage is injected into the cavity, emptied from the pus of the focus. When opening an abscess, a swab moistened with the drug is introduced into the wound.

Deep treatment pyoderma carry out the work intradermal injections funds in one place of 0.1-0.5 ml or in several places in a total dose of up to 2 ml. Introductions are made every 24 hours, only 10 injections.

For an introduction to abdominal, pleural, articular cavities use capillary drainage, inject up to 100 ml of bacteriophage every other day. Only 3-4 such introductions.

At cystitis the drug is injected into the bladder using a catheter.

At purulent bursitis, pleurisy or arthritis the drug is injected into the cavity, previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 injections.

Staphylococcal bacteriophage is also used orally in the form of tablets in the treatment of urogenital infections ( cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis ), intestinal infections and other diseases caused by staphylococcus aureus.

How to use Staphylococcal Bacteriophage in intestinal staphylococcal lesions and intestinal dysbacteriosis : the drug is used orally on an empty stomach three times a day 2 hours before meals; rectally in the form of suppositories or enemas, the drug is prescribed once a day. Treatment is carried out for 7-10 days.

For newborns, in the first 2 doses, the drug is diluted with an equal amount of water. It can also be mixed with breast milk.

At sepsis or enterocolitis in newborns, the remedy is used by setting high enemas up to three times a day. A combination of rectal and oral administration is allowed.

At therapy for pyoderma, omphalitis, festering wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with dressings of 5-20 grams up to two times a day.

In prevention enterocolitis and sepsis in newborns at risk of developing nosocomial infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal bacteriophage is used to irrigate the affected mucous membranes and skin with purulent-inflammatory lesions, burns, septic wounds and sore throat .

Modern medical practice gives great attention the use of vaccines, serum preparations, toxoids and various phages, this group includes the staphylococcal bacteriophage.

The main feature of such a drug as a specific bacteriophage is to lyse staphylococcus quickly and efficiently. This means that the bacteriophage staphylococcal bacteriophage is a staphylococcal "splitter" and has a specific action. A bacteriophage or bacteria eater is a type-specific virus that reproduces in the "body" of a microbe and has a detrimental effect on it. A bacteriophage instruction describes how an agent causes the cells of a particular pathogen to die without infecting other bacteria. This is its main advantage, but if you carefully study the annotation for the streptococcal bacteriophage, its other advantages will become obvious:

• activity against antibiotic-resistant strains;
• possibility effective treatment immunocompromised patients;
• good performance when used in people who are on constant therapy with hormones and drugs that suppress the activity of the immune system.

Staphylococcal bacteriophage helps patients with frequent bacterial infections due to the influence of Staphylococcus aureus. Excellent drug for the treatment of frequently ill children. A parent should not be afraid of the word “virus” at all. The described phages are active only against bacteria, and harmful ones.

Specific phages pathogenic for staphylococcus can be found in complex tool- bacteriophage intesti. This medication contains a whole group of phagolysates that are active against common bacteria that cause mainly intestinal infections: Shigella, entero- and staphylococci, Proteus, Salmonella and Pseudomonas aeruginosa. Despite the undeniable merits of a single agent and its combined variant, it was not included in the ZhVLP list.

General characteristics of the drug

In what form can this drug (PM) be found on pharmacy shelves? The bacteriophage staph instruction describes how liquid. This medication is good for the treatment of intestinal infections and some purulent pathologies. For the treatment of lesions skin developed:

• creams;
• ointments;
• aerosols.

You can find the drug in the form rectal suppositories. The variety of forms makes the drug convenient to use and adds to a number of its advantages.

Contraindications and side effects

One of the good news for patients who are tired of side effects associated with taking antibiotics is the absence of those in phagolysates. By at least for staphylococcal bacteriophage, the instruction does not describe a single contraindication or negative response of the body after the use of drugs.

by the most serious consequence after taking it, doctors recorded a rapidly passing hyperemia and a slight inflammatory process. This phenomenon was observed with the injection method of administering the drug.

Such a tool as a staphylococcal bacteriophage instructions for use recommends injecting directly into the focus of inflammation. In this case, the procedure is carried out by the method

• installations, that is, introductions through a catheter (for cystitis);
• capillary drainage (used for abdominal infusions: into the pleural or cavity, joint);
• washings, instillations, the introduction of turundas in ENT pathologies;
• injections directly into the focus of infection with carbuncles or furunculosis;
• s / c injections for pyodermatitis;
• injections into the wound after it has been treated by a bone surgeon for poliomyelitis;
• into the cavity left after pumping purulent exudate with an abscess.

With limited lesions of the staphylococcal bacteriophage, the instructions for use recommend taking it simultaneously orally or externally (locally).

And you need to do this from 1 to 4 weeks. Usually in injection form phage is prescribed for 5-10 injections. When rinsing drugs can be used 3 times a day. With the intracavitary administration of the drug, 3-4 procedures are allowed.

Bacteriophage staphylococcal instruction for children recommends prescribing from the neonatal period. Most often, this drug is prescribed for:

1. enterocolitis of coccal nature;
2. sepsis;
3. burns, wounds seeded with this pathogen;
4. omphalitis;

Staphylococcal bacteriophage in Staphylococcus aureus is most in demand with strains resistant to antibacterial agents. In the aerosol version, the staphylococcal bacteriophage instructions for use for children recommend using it for purulent-inflammatory lesions of the skin.

The cost of the drug

Considering all the advantages described on Bacteriophage staphylococcal instruction- the price of a tool that practically does not have side effects may be of interest to potential buyers.

Staphylococcal bacteriophage is easy to buy in almost any pharmacy network. Its cost is variable. The price of a bacteriophage depends on the volume of drugs and the form of its release. And also from the region where it will be purchased and the pharmacy chain. The most common form of medication is liquid. On a bacteriophage staphylococcal price in this design ranges from 220 rubles and almost up to 1000 rubles, and sometimes even higher. A little more than 200 rubles costs 20 ml of a solution, and a 100 ml bottle will “pull” already 1000 rubles.

Before you buy a staphylococcal bacteriophage, consult your doctor how much money you need and how much should be purchased at a time.

How easy it is to kill Staphylococcus aureus? (Doctor Komarovsky)

Staphylococcal bacteriophage - official instructions for use

Bacteriophages are substitutes for antibiotics, do not affect the immune system, do not affect the work of the intestine. They can be used from an early age.

Similar drugs

Only by action can you pick up analogues for the staphylococcal bacteriophage. The closest is the bacterial phage inesti, sextaphage. With inflammation of the bladder, you can prescribe:

• Dioxidine,
• Monural.

The latter drug can be recommended for meningitis of a staphylococcal nature, damage to the pleura,. For processing wound surface use Chlorhexidine. In each case, the doctor will select a substitute. For example, if a patient needs a streptococcal, staphylococcal bacteriophage, and a number of other phagolysates, a drug with any chemically active substance that can comprehensively suppress harmful bacteria should be preferred.

Summary of Reviews

In general, this drug has earned a positive attitude from both patients and doctors. According to the reviews of young mothers, the bacteriophage helped to cope with allergies, up to severe forms eczema caused by the reaction of the baby's body to the waste products of these conditionally pathogenic microorganisms which easily become pathogenic. Moreover, preliminary treatment with antihistamines was ineffective.

In the case of intestinal dysbacteriosis and dysbiosis in children, against the background of the flourishing of staphylococcus, this medication also works well. Adult patients are often happy with the effect that this medication has on furunculosis and frequent relapses carbuncles. It helps to cope well with the problem even with the weak effectiveness of such a proven remedy as autohemotherapy. Patients are called mainly for bad taste agents for oral administration.

Despite the absence of contraindications or unpleasant consequences the use of the drug is a medicine, it must be used as prescribed by the doctor and in the doses indicated by him. Our site is for informational purposes. Therefore, please do not use the information provided here as instructions for action.

Treatment with bacteriophages: when antibiotics no longer help

INSTRUCTIONS for the use of a medicinal product for medical use Staphylococcal bacteriophage

Bacteriophage staphylococcal liquid - instructions for use. Indications for use, composition, pharmacological properties, reviews.

Name of the medicinal product: Staphylococcal bacteriophage.

Dosage form: Solution for oral, topical and external use.

Average price for Staphylococcal bacteriophage in Russia (2014):

Average price: 880 rubles.
Maximum price: 1868 rubles.

Compound

Ingredients of Staphylococcal Bacteriophage: In 1 ml medicinal product contained active substance sterile filtrate of phagolysates of bacteria of the genus Staphylococcus up to 1 ml.

Excipients: Preservative-8-hydroxyquinoline sulfate - 0.0001 g/ml (calculated content); or 8-hydroxyquinoline sulfate monohydrate - 0.0001 g / ml (in terms of 8-hydroxyquinoline sulfate, the content is calculated).

Description: Staphylococcal Bacteriophage is a clear liquid yellow color varying intensity.

Pharmacotherapeutic group of the medicinal product: MIBP bacteriophage.

Biological properties: Staphylococcal bacteriophage causes specific lysis of Staphylococcus bacteria.

Indications

Indications for the use of the drug Bacteriophage staphylococcal:

• Treatment and prevention of purulent-inflammatory and enteral diseases caused by bacteria of the genus Staphylococcus in adults and children.
• diseases of the ear, throat, nose, respiratory tract and lungs (inflammation of the sinuses, middle ear, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
• surgical infections (suppuration of wounds, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis);
• urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis);
• enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbacteriosis;
• generalized septic diseases;
• purulent-inflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.);
• other diseases caused by staphylococci.

In severe manifestations of staphylococcal infection, the drug is prescribed as part of complex therapy.

FROM preventive purpose Staphylococcal Bacteriophage is used for the treatment of postoperative and freshly infected wounds, as well as for the prevention of nosocomial infections according to epidemic indications.

An important condition for effective phage therapy is the preliminary determination of the sensitivity of the pathogen to the bacteriophage and early application drug Bacteriophage staphylococcal;

Contraindications to the drug Bacteriophage staphylococcal:

Individual intolerance or sensitivity to any of the components of the drug.

The use of the drug Bacteriophage staphylococcal during pregnancy and during breastfeeding:

It is advisable to use the drug in the presence of infections caused by phage-sensitive strains of staphylococci (on the recommendation of a doctor).

Dosage and administration of Staphylococcal Bacteriophage:

The drug is used for oral administration (through the mouth), rectal administration, applications, irrigation, injection into the cavity of wounds, vagina, uterus, nose, sinuses and drained cavities. Before use, the bacteriophage vial must be shaken and examined. The Staphylococcal Bacteriophage preparation should be transparent and free of sediment.

Recommended dosages of Staphylococcal Bacteriophage:

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug Staphylococcal Bacteriophage orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If chemical antiseptics were used to treat wounds before using the bacteriophage, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the focus of infection, Staphylococcal bacteriophage is used:

1. In the form of irrigation, lotions and plugging in a volume of up to 200 ml, depending on the size of the affected area. In case of abscess after removal of purulent contents by means of a puncture, the Staphylococcal Bacteriophage preparation is administered in an amount less than the volume of the removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound in 10-20 ml.

2. When injected into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which Staphylococcal Bacteriophage is injected for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, Staphylococcal Bacteriophage is injected through a cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.

4. With purulent-inflammatory gynecological diseases the drug Staphylococcal Bacteriophage is injected into the cavity of the vagina, uterus at a dose of 5-10 ml once a day, with colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are laid for 2 hours.

5. In purulent-inflammatory diseases of the ear, throat, nose, the drug is administered at a dose of 2-10 ml 1-3 times a day. Staphylococcal bacteriophage is used for rinsing, washing, instillation, introduction of moistened turundas (leaving them for 1 hour).

6. For enteral infections, intestinal dysbacteriosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine two-time oral administration with a single rectal administration a single age dose of bacteriophage in the form of an enema after a bowel movement.

The use of bacteriophage Staphylococcal in children (up to 6 months)

With sepsis, enterocolitis of newborns, including premature babies

The bacteriophage is used in the form of high enemas (through a vent tube or catheter) 2-3 times a day at a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug through the mouth. In this case, it is mixed with breast milk. Perhaps a combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug. The course of treatment is 5-15 days. With a recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, Staphylococcal bacteriophage is used as enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, infected wounds, the Staphylococcal Bacteriophage preparation is used in the form of applications twice daily (a gauze napkin is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).

Side effect of the drug bacteriophage Staphylococcal

None.

Overdose

Not marked.

Interaction with other drugs.

The use of the drug Bacteriophage staphylococcal is possible in combination with other medicines including antibiotics.

Special instructions.

The staphylococcal bacteriophage is not suitable for use in vials with broken integrity or labeling, if the expiration date has expired, if it becomes cloudy.

Due to the content in the preparation Bacteriophage staphylococcal nutrient medium in which bacteria can develop from environment, causing turbidity of the drug, it is necessary to observe the following rules when opening the vial:

• wash your hands thoroughly;
• treat the cap with an alcohol-containing solution; remove the cap without opening the cork;
• don't plug inner surface on a table or other objects;
• do not leave the vial open
• Opened vials should only be stored in the refrigerator.

Opening the vial of Staphylococcal Bacteriophage and extracting the required volume of the drug can be carried out with a sterile syringe by puncturing the stopper. The drug Staphylococcal Bacteriophage from an opened vial, subject to the storage conditions, the above rules and the absence of turbidity, can be used during the entire shelf life.

Influence on the ability to drive vehicles, mechanisms

Not installed.

The form of release of the drug Bacteriophage staphylococcal

Solution for oral, topical and external use in vials of 20 ml or 100 ml. 4 or 8 bottles of 20 ml or 1 bottle of 100 ml in a cardboard box with instructions for use.

Storage and transportation conditions

Storage in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8°C in a dry place protected from light and out of the reach of children.

Transportation in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8°C, transportation at a temperature of 9 to 25°C is allowed for no more than 1 month.

Shelf life of the drug Bacteriophage staphylococcal.

Shelf life 2 years. Expired Bacteriophage staphylococcal drug should not be used.

Holiday conditions.

Bacteriophage staphylococcal is released without a prescription.