Staphylococcal bacteriophage (Bacteriophagum Staphylococcus): instructions for use. Staphylococcal bacteriophage: instructions for use

• 50, or 100 ml of such a solution in a vial - one vial in a cardboard box.
• 20 ml of this solution in a bottle - four bottles in a cardboard box.
• 25 ml of this solution in an aerosol can - one package in a carton.
• 10 and 20 grams of ointment in a bottle, one bottle in a cardboard box.
• 10 candles per pack, one pack per carton.
• 10, 25 and 50 tablets per pack, one pack per carton.

pharmachologic effect

Antibacterial action.

Pharmacodynamics and pharmacokinetics

What is a bacteriophage?

This drug is relatively new on the drug market, and many patients have a natural question: "Bacteriophage - what is it?"

Bacteriophages are viral particles that kill only certain types of pathogenic bacteria. On their basis, appropriate preparations are created. The discovery of drugs belongs to the Canadian scientist Felix D'Herelle.

The structure of bacteriophages

A typical bacteriophage consists of a tail and a head. The tail is usually 3-4 times longer than the diameter of the head. The head contains double-stranded or single-stranded RNA or DNA with inactive transcriptase surrounded by a shell of protein or lipoprotein called capsid .

Reproduction of bacteriophages

As with conventional viruses, the reproduction cycle in lytic bacteriophages can be roughly divided into phage adsorption on the cell wall, DNA introduction, phage reproduction, and evacuation of daughter populations from the cell.

Attachment of a phage to a bacterial cell occurs due to its surface structures, which serve as specific receptors for viruses. In addition to receptors, phage attachment depends on temperature, the acidity of the medium, the presence of cations, and a number of other compounds. Up to 300 virus particles can be adsorbed on one cell.

After attachment, the cell wall is cleaved lysozyme. Simultaneously, calcium ions are released, activating ATPase - this causes the contraction of the sheath and the introduction of the tail shaft into the cage. The virus DNA is then injected into the cytoplasm. Having penetrated into the bacterium, the phage DNA takes control of the cell's genetic apparatus, carrying out the reproductive cycle of the phage.

First of all, there is a synthesis of enzymes necessary for the formation of copies of phage DNA ( DNA polymerases, thymidylate synthetase, kinases ). It takes 5-7 minutes from the moment of infection. RNA polymerase cells convert viral DNA into mitochondrial RNA, which is translated by ribosomes into "early" proteins. "Early" proteins are mainly viral RNA polymerase and proteins that limit bacterial gene expression. Viral RNA polymerase produces transcription of the so-called "late" proteins necessary for the assembly of new phage particles.

Reproduction of nucleic acids occurs due to the activity synthesized DNA polymerases virus. By the end of the cycle, the phage components are combined into a mature virion.

Evacuation of bacteriophage populations from the cell

Newly biosynthesized proteins in the cytoplasm form a pool of precursors. The other pool includes progeny DNA. Specialized regions in the DNA of the virus induce the association of these proteins around groups of nucleic acid molecules and the synthesis of new heads. The head interacts with the tail, forming a daughter phage. After the release of the offspring, the host cell is destroyed, releasing a new population.

An alternative to cell destruction can be an integrative form of interaction in which the phage DNA, instead of replication, is integrated into the bacterial chromosome or becomes plasmid . As a result, the virus genome replicates along with the host's DNA.

Types of Bacteriophages

The use of bacteriophages determines their clinical classification. Based on this thesis, the following types of bacteriophages can be distinguished:

• bacteriophages for therapy intestinal infections : dysenteric, polyvalent, salmonella ABCDE-groups, typhoid, coliproteic, intesti-bacteriophage (a mixture of phages against the most common pathogens of intestinal infections);
• bacteriophages for therapy purulent-septic lesions : Klebsiella pneumonia, Klebsiella polyvalent, Pseudomonas aeruginosa, antistaphylococcal bacteriophage, coli, proteus, streptococcal, combined pyobacteriophage (a mixture of phages that destroy most likely pathogens of purulent-septic infections).

The use of bacteriophage preparations in medicine is becoming more widespread due to the increasing cases of polyvalent resistance of pathogens to antibacterial agents.

Indications for use

How to take this medicine? The drug is used for the treatment and prevention of diseases caused by staphylococcus aureus:

• urogenital infections ( , salpingoophoritis, );
• infections in surgery (burns, suppuration of wounds, , boils, phlegmon, felons, paraproctitis, );
• diseases of the throat, ear, nose, respiratory organs (, sinuses, , pleurisy );
• digestive tract infections gastroenterocolitis ), , ;
• prevention of postoperative septic complications;
• prevention of hospital infections.

Contraindications

There are no contraindications to the use of this remedy.

Side effects

Undesirable reactions to the administration of the drug have not been established.

With the intradermal route of administration, short-term hyperemia and inflammation.

Instructions for Staphylococcal bacteriophage (Method and dosage)

The drug is injected into the site of infection. The frequency of injections and their size is determined by determining the clinical form of the disease, the nature of the infectious focus and standard recommendations. The average duration of treatment is 5-15 days. In cases of relapse, additional courses of treatment are possible. Instructions for the use of staphylococcal bacteriophage for children and adults are somewhat different. Recommendations for the use of the drug for children are given at the end of the section.

Liquid phage is allowed to be applied topically in the form of lotions, irrigation or plugging in a volume of up to 200 ml, taking into account the size of the affected area. Also for topical use is an ointment.

Therapy purulent-inflammatory limited lesions it is advisable to carry out both locally and orally for 1-4 weeks.

At purulent-inflammatory lesions of the throat, ear or nose the drug is used for rinsing, instillation, washing and administration of moistened turundas 2-10 ml up to three times a day.

At carbuncles and boils liquid bacteriophage is injected directly into the focus or around it, daily, 0.5-2 ml. In total, up to 5 injections are made for the course of treatment.

Treatment chronic osteomyelitis carried out by infusion of the drug into the wound immediately after surgical treatment.

At abscesses bacteriophage is injected into the cavity, emptied from the pus of the focus. When opening an abscess, a swab moistened with the drug is introduced into the wound.

Deep treatment pyoderma carried out by intradermal injections of the agent in one place by 0.1-0.5 ml or in several places in a total dose of up to 2 ml. Introductions are made every 24 hours, only 10 injections.

For an introduction to abdominal, pleural, articular cavities use capillary drainage, inject up to 100 ml of bacteriophage every other day. Only 3-4 such introductions.

At cystitis the drug is injected into the bladder using a catheter.

At purulent bursitis, pleurisy or arthritis the drug is injected into the cavity, previously emptied of pus, 20 ml every other day. The course of treatment is 3-4 injections.

Staphylococcal bacteriophage is also used orally in the form of tablets in the treatment of urogenital infections ( cystitis, pyelonephritis, pyelitis, salpingoophoritis, endometritis ), intestinal infections and other diseases caused by staphylococcus aureus.

How to use Staphylococcal Bacteriophage in intestinal staphylococcal lesions and intestinal dysbacteriosis : the drug is used orally on an empty stomach three times a day 2 hours before meals; rectally in the form of suppositories or enemas, the drug is prescribed once a day. Treatment is carried out for 7-10 days.

For newborns, in the first 2 doses, the drug is diluted with an equal amount of water. It can also be mixed with breast milk.

At sepsis or enterocolitis in newborns, the remedy is used by setting high enemas up to three times a day. A combination of rectal and oral administration is allowed.

At therapy of pyoderma, omphalitis, purulent wounds in newborns, the drug is used in the form of applications twice a day and in the form of tablets - 1 piece up to four times a day. The ointment is used locally with dressings of 5-20 grams up to two times a day.

In prevention enterocolitis and sepsis in newborns with the risk of developing a nosocomial infection or intrauterine infection, the drug is used in the form of enemas twice a day for a week.

In aerosol form, Staphylococcal bacteriophage is used to irrigate the affected mucous membranes and skin with purulent-inflammatory lesions, burns, septic wounds and sore throat .

Bacteriophage refers to biological products that contain beneficial viruses that affect pathogens. The peculiarity of these funds is that a certain medicine is able to fight only one type of virus. reviews of doctors about which they characterize it as an effective remedy for many diseases, refers specifically to such medicines. About him and will be discussed further.

It should be noted right away that without a doctor's prescription, such a medicine cannot be taken. Self-medication can be bad for health. The doctor prescribes such a medicine only after establishing an accurate diagnosis and determining the type of harmful viruses in the body.

general information

The use of drugs with bacteriophages

How well these drugs work on the body, reviews will tell. Staphylococcal bacteriophage copes well with purulent infections. It is used for the treatment of mucous membranes, skin and visceral organs.

In addition to staphylococcal infections, certain ones are able to cope with streptococci, salmonella, enterococcal bacteria and a number of other harmful microorganisms.

When is bacteriophage staphylococcal used?

Reviews of doctors say that this medicine will help with the following diseases:

• sinusitis;
• angina;
• otitis;
• laryngitis and pharyngitis;
• pneumonia, bronchitis and tracheitis;
• pleurisy;
• purulent wounds, abscess, felon, furuncle, complex burns with suppuration;
• inflammatory processes of the urinary system, including cystitis, nephritis and pyelonephritis;
• diseases of the digestive system, including gastritis, cholecystitis, gastroenterocolitis;
• intestinal dysbiosis.

Release form

Staphylococcal bacteriophage is available in bottles of 100 ml in a cardboard box or 20 ml in a pack. Each box contains detailed instructions for use.

The drug is also available in tablets, rectal suppositories and aerosol for comfortable use in various diseases.

Methods of using the drug and reviews

Staphylococcal bacteriophage, depending on the type of inflammatory focus, can be used as follows:

• The solution is injected into the wound with an abscess after surgery in the form of a puncture to remove purulent contents. The amount of the drug depends on the volume of the removed pus and can reach 200 ml. Also, the drug is effective in osteomyelitis, as evidenced by the reviews. Staphylococcal bacteriophage is poured into the wound after treatment, 20 ml each. The action of the medicine is enhanced if, in addition to this, irrigation and lotions are done.
• The drug is injected into limited cavities, such as pleural and articular, while leaving a special drip drainage, through which a solution is added after a while.

• Also, the medicine can be prescribed by a doctor for oral administration for diagnoses such as cystitis, urethritis, pyelonephritis. For patients with a drained bladder or pelvis, the drug is administered orally through a cystoma or nephrostomy up to 2 times a day (from 20 to 50 ml into the ureter and from 5 to 7 ml into the pelvis).
• The drug will help to cope with a number of gynecological diseases, and this is confirmed by numerous reviews. Staphylococcal bacteriophage is prescribed to patients with purulent-inflammatory foci. The solution is injected into the vagina or uterus, 5-10 ml every day. With a disease called colpitis, irrigation of 10 ml and tamponing 2 times a day for 2 hours will be effective.
• This drug will help to cope with. Very often, a staphylococcal bacteriophage is prescribed for angina. Reviews of doctors suggest that rinsing with this solution contributes to the rapid recovery of the patient. In addition, the medicine is instilled into the nose and used to wet the turundas in the ears.
• How are staphylococcal bacteriophage reviews positioned? With dysbacteriosis and infectious lesions, the drug shows good results. It is prescribed 2-10 ml up to three times a day an hour before a meal. In addition, rectal administration of the drug is also practiced to achieve the maximum effect of therapy.
• Staphylococcal bacteriophage will help with furunculosis. Patient reviews indicate that aerosol spraying and lotions in the form of applications accelerate the process of tissue repair and lead to a speedy recovery.

How is staphylococcal bacteriophage prescribed for adults? Reviews of doctors say that with an adequate approach to therapy using antibiotics and other drugs, there is a positive trend in such serious diseases as abscess, sepsis and other manifestations of advanced infection. However, an early appeal to a medical institution will allow timely diagnosis of the cause of a particular disease and provide assistance without waiting for complications and consequences.

Assignment to children

The drug is widely used in pediatrics. What do they say about such a medicine as bacteriophage staphylococcal reviews? For babies, a disease such as omphalitis is very dangerous. It is manifested by suppuration at the umbilical wound, redness of the skin around it and swelling, as well as an inflammatory process in the subcutaneous fat layer. The cause of this disease is a staphylococcal infection. Disease progression can lead to sepsis. Timely systematic treatment of the wound with a composition such as staphylococcal bacteriophage will help to quickly neutralize the action of harmful microorganisms, which will lead to recovery.

Another common disease of infants is vesiculopustulosis. It is characterized by skin lesions, which are accompanied by the formation of vesicles with cloudy contents. The condition of a small patient depends on the number of rashes. The cause of the disease is also which can be defeated by lotions with a remedy such as staphylococcal bacteriophage.

Feedback on the treatment of children of different ages

In older children, staphylococcal lesions of the skin are often manifested by furunculosis and folliculitis, in some cases hydradenitis and carbuncles can be observed. How does the staphylococcal bacteriophage advise to use the instruction? For children (reviews of doctors confirm this), in the treatment of skin manifestations of this type, it will be effective to take an aerosol, as well as the use of lotions and applications on the affected areas of the skin.

In diseases of the gastrointestinal tract and respiratory system caused by staphylococci, which are characterized by obvious signs of intoxication, oral and rectal administration of the drug can be prescribed.

What should be studied before taking Staphylococcal bacteriophage? Reviews. For children, timely antibiotic therapy is very important, which should be preceded by laboratory tests to identify the bacteria that caused the disease. This will help to quickly and without complications stabilize the condition of a small patient, which will lead to recovery.

The drug is a phagolysate filtrate that is active against staphylococcal bacteria of the most common phage types, incl. staphylococcus aureus.

pharmachologic effect

Staphylococcal bacteriophage - immunobiological preparation, phage.

Staphylococcal bacteriophage has the ability to specifically lyse staphylococcal bacteria isolated during purulent infections, incl. golden staphylococcus.

Indications for use Staphylococcal bacteriophage

Staphylococcal bacteriophage is used for the treatment and prevention of purulent infections of the skin, mucous membranes, visceral organs caused by staphylococcal bacteria, as well as for dysbacteriosis:

• diseases of the ear, throat, nose, respiratory tract and lungs (sinusitis, otitis, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy);
• surgical infections (purulent wounds, infected burns, abscess, phlegmon, furuncle, carbuncle, hydradenitis, felon, infiltrated and abscessed staphylococcal sycosis, paraproctitis, mastitis, bursitis, tendovaginitis, osteomyelitis);
• urogenital pathology (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis);
• enteral pathology (gastroenterocolitis, cholecystitis, intestinal dysbacteriosis);
• generalized septic diseases;
• purulent-inflammatory diseases of newborns (omphalitis, gastroenterocolitis, sepsis);
• other diseases of staphylococcal etiology;
• prevention of purulent processes in freshly infected wounds (operations of the abdominal and chest cavity, street and industrial injuries, etc.); for the prevention of nosocomial infections according to epidemic indications.

Contraindications to the use of Staphylococcal Bacteriophage

Individual intolerance.

Staphylococcal bacteriophage side effects

Reactions to the introduction of staphylococcal bacteriophage have not been established.
With intradermal administration, there may be rapidly passing reversible redness and inflammation.

drug interaction

The use of staphylococcal bacteriophage does not exclude the use of other drugs.

It is possible to produce combined treatment with staphylococcal bacteriophage in combination with antibiotics.

Dosage of Staphylococcal bacteriophage

An important condition for effective phage therapy is the preliminary determination of the phage sensitivity of the pathogen (determination of sensitivity to staphylococcal bacteriophage of strains isolated from the patient).
Staphylococcal bacteriophage is introduced into the focus of infection. The duration of the course of treatment is 5-15 days. Doses and method of administration depend on the nature of the focus of infection (locally in the form of irrigation, lotions and plugging; intradermally; in the cavity - abdominal, pleural, articular; into the bladder through a catheter; per os and per rectum). With a recurrent course of the disease, repeated courses of treatment are possible.

Locally in the form of irrigation, lotions and plugging with liquid phage in an amount of up to 200 ml, taking into account the size of the affected area, or smearing with ointment.
Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth for 7-20 days.
In purulent-inflammatory diseases of the ear, throat, nose, staphylococcal bacteriophage is administered at a dose of 2-10 ml 1-3 times a day; used for rinsing, washing, instillation, the introduction of moistened turundas (leaving them for 1 hour).
With boils and carbuncles, a liquid staphylococcal bacteriophage is injected directly into the focus or under the base of the infiltrate, as well as around it. Injections are made daily, every other day, depending on the reaction in successively increasing doses: for 1 injection - 0.5 ml, then 1 - 1.5 - 2 ml. In total, 3-5 injections are carried out during the treatment cycle.

With abscesses, staphylococcal bacteriophage is injected into the cavity of the focus after puncture removal of pus. The amount of the injected drug should be slightly less than the volume of the removed pus. When an abscess is opened, a tampon is introduced into the cavity, abundantly moistened with staphylococcal bacteriophage.

In chronic osteomyelitis, staphylococcal bacteriophage is poured into the wound immediately after its surgical treatment.
For the treatment of deep forms of pyodermatitis, staphylococcal bacteriophage is used intradermally in small doses of 0.1-0.5 ml in one place or, if necessary, up to 2 ml in several places. A total of 10 injections every 24 hours.
Introduction to cavities - abdominal, pleural, articular and others up to 100 ml of bacteriophage. Capillary drainage is left, through which the bacteriophage is re-introduced every other day, only 3-4 times.

With cystitis, a staphylococcal bacteriophage is introduced into the bladder cavity using a catheter.
With purulent pleurisy, bursitis or arthritis, a staphylococcal bacteriophage is introduced into the cavity after removal of pus from it in an amount of up to 20 ml. and more, every other day, 3-4 times.
Inside in the form of tablets, staphylococcal bacteriophage is used to treat urogenital infectious pathology - cystitis, pyelitis, pyelonephritis, endometritis, salpingo-oophoritis, enteral infections and other diseases caused by staphylococcus bacteria.

In intestinal forms of the disease caused by staphylococcus and intestinal dysbacteriosis, liquid staphylococcal bacteriophage is used: inside 3 times a day on an empty stomach 1.5-2 hours before a meal; rectally - once a day (liquid in the form of enemas or suppositories). With intestinal dysbacteriosis, treatment is carried out for 7-10 days under bacteriological control. For children of the first days of life, in the first two doses, the staphylococcal bacteriophage is diluted with boiled water 2 times. In the absence of adverse reactions (regurgitation, rash on the skin), the undiluted drug is subsequently used. In this case, it can be mixed with breast milk.
With sepsis, enterocolitis of newborns, including premature babies, staphylococcal bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day. Perhaps a combination of rectal (in enemas) and oral (through the mouth) use of the drug.

In the treatment of omphalitis, pyoderma, infected wounds in newborns, the staphylococcal bacteriophage is used as applications twice daily (a gauze cloth is moistened with a staphylococcal bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).
Recommended dosage of Bacteriophage staphylococcus:

Age Dose per 1 dose Inside liquid In enema (ml.) Up to 6 months 5-10 ml 20 From 6 to 12 months 10-15 ml 20 From 1 year to 3 years 15-20 ml 40 from 3 to 8 years 20-50 ml 40-100 From 8 years and older 20-50 ml 40-100 Frequency of taking a liquid preparation - 2-3 times a day.

Staphylococcal bacteriophage is used for prophylaxis in the amount of 50 ml. for irrigation of postoperative wounds, etc.
In order to prevent sepsis and enterocolitis in newborns with intrauterine infection or the risk of nosocomial infection, staphylococcal bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

Precautionary measures

Bacteriophage staphylococcal liquid is not suitable for use with turbidity and the presence of flakes.

Staphylococcal bacteriophage: instructions for use

Compound

Description

pharmachologic effect

Pharmacokinetics

Indications for use

Contraindications

Dosage and administration

The drug is used for oral administration (through the mouth), rectal administration, applications, irrigation, injection into the cavity of wounds, vagina, uterus, nose, sinuses and drained cavities. Before use, the bacteriophage vial must be shaken and examined. The drug should be clear and free of sediment.

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally 2-3 times a day on an empty stomach 1 hour before meals from the first day of the disease for 7-20 days (according to clinical indications).

If before the use of bacteriophage, chemical antiseptics were used to treat wounds, the wound should be thoroughly washed with a sterile sodium chloride solution of 0.9%.

Depending on the nature of the focus of infection, the bacteriophage is used:

1. In the form of irrigation, lotions and plugging in a volume of up to 200 ml, depending on the size of the affected area. In an abscess after removal of purulent contents by puncture, the drug is administered in an amount less than the volume of the removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound in 10-20 ml.

2. When injected into cavities (pleural, articular and other limited cavities) up to 100 ml, after which capillary drainage is left, through which the bacteriophage is injected for several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is administered through a cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.

4. In purulent-inflammatory gynecological diseases, the drug is injected into the cavity of the vagina, uterus at a dose of 5-10 ml once a day, with colpitis - 10 ml by irrigation or tamponing 2 times a day. Tampons are laid for 2 hours.

5. In purulent-inflammatory diseases of the ear, throat, nose, the drug is administered at a dose of 2-10 ml 1-3 times a day. Bacteriophage is used for rinsing, washing, instillation, introduction of moistened turundas (leaving them for 1 hour).

6. For enteral infections, intestinal dysbacteriosis, the drug is taken orally 3 times a day 1 hour before meals. It is possible to combine a double oral administration with a single rectal administration of a single age dose of bacteriophage in the form of an enema after a bowel movement.

The use of bacteriophage in children (up to 6 months).

With sepsis, enterocolitis of newborns, including premature babies, bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day at a dose of 5-10 ml. In the absence of vomiting and regurgitation, it is possible to use the drug through the mouth. In this case, it is mixed with breast milk. Perhaps a combination of rectal (in the form of high enemas) and oral (through the mouth) use of the drug. The course of treatment is 5-15 days. With a recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, the bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, infected wounds, the drug is used in the form of applications twice daily (a gauze cloth is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of ​​the skin).

Side effect

Overdose

Interaction with other drugs

Application features

Precautionary measures

Release form

Storage conditions

Best before date

Terms of dispensing from pharmacies

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

The preparation of staphylococcal bacteriophage is a light yellow liquid, odorless and tasteless. A distinctive feature of all bacteriophages is the ability to selectively destroy a specific type of pathogens, biting into a bacterial cell and feeding on its life-supporting structures, thereby contributing to the rapid death of the cell. Staphylococcal phage thus acts on staphylococcal bacteria.

The bacteriophage cell includes a head containing single- or double-stranded RNA with a deactivated transcriptase in the amino acid shell, and a tail that is approximately 3 times longer than the head.

Attaching to a staphylococcus cell, the phage secretes lysozyme, which destroys the cell wall, while calcium is released and activates ATP. The phage injects its RNA into the cell and from that moment the control of the bacteriophage over the genetic apparatus of the cell begins. Thanks to the synthesis of multiple enzymes, it becomes possible to form many new copies of the phage that capture new bacterial cells.

Is it possible to give to children

The drug is approved for use in children from six months old. When using and selecting a dosage, the instructions in this manual must be strictly observed.

If a child has an adverse reaction to the syringe test, it is not recommended to give the drug. The bacteriophage does not provoke changes in the intestinal microflora, therefore, when using it, there is no need to resort to antibiotics.

Indications for use

• Infectious inflammatory diseases of the ENT organs.
• Infections of the genitourinary system.
• Intestinal infections and dysbacteriosis.
• Other purulent-inflammatory processes, the diagnosis of which revealed the presence of staphylococci.

Forms of release of the drug and conditions for dispensing from pharmacies

The drug is produced in the form of a solution for oral and external use in opaque glass vials with a capacity of 20, 50 or 100 ml. Vials with a capacity of 20 ml are packed in cardboard boxes of 4 vials, with a capacity of 50 and 100 ml - are produced in individual packaging. All packages have instructions for use inside.

The solution is also available as aerosol, in a 25 ml bottle with instructions for use.

Tablets are produced in blisters of 10, 25 and 50 pieces, packed in a cardboard box. One box contains one blister and instructions for use.

Candles are produced in packs of 10 pieces in a cardboard box.

Ointment Produced in tubes of 10 and 20 grams, in a cardboard box with instructions for use.

All forms of the drug are dispensed in pharmacies without a prescription.

Instructions for use

The course of treatment with bacteriophage is 6-9 days and involves a combination of rectal and oral administration of the drug.

For rectal use, children under 6 months of age are supposed to inject 10 ml of phage, from 6 months to a year - 20 ml, from one to three years - 30 ml, for older children - 50 ml.

Dosage for oral administration: up to 6 months - 5 ml, from 6 months to a year - 10 ml, from one to three years - 35 ml, from 3 to 8 years - 20 ml, older - 30 ml. Children up to a year in the first two doses are given half the indicated dosage of the drug, mixed with milk or water.

Aerosol with phage is used for irrigation of the oropharyngeal cavity in case of angina, pharyngitis, for irrigation of purulent and inflamed areas of the skin and mucous membranes.

For festering wounds, a combination of topical application (bandage with ointment, change twice a day) and tablets (up to 4 pieces per day) is required. Before taking be sure to check with your doctor!

Compound

1 ml of solution contains up to 1 ml of active substance - phagolysates of staphylococcal bacteria.

Excipients: preservative 8-hydroxyquinoline sulfate - about 0.1 ml.

Contraindications

In pediatric practice, there are practically no contraindications for the use of bacteriophage preparations. An exception is the occurrence of pathological reactions after a test enema during the use of bacteriophages for infants.

Side effects

When administered subcutaneously into the body, short-term swelling and redness of the surface may be observed.

Otherwise, undesirable effects when taking the drug are possible only if there is an increased individual sensitivity to the active substance. Before starting to use the product for a child, it is advisable to test for a pathological reaction by placing a microclyster with a bacteriophage solution. If adverse reactions occur, oral administration of the drug is not allowed.

Analogues

• Cubicin
• Trobicin
• Nitroxoline
• Dioxidine