The drug Dolobene indications for use. How to use the gel from bruises and bruises. Import and Russian analogues

PRICE DOLOBENE

Pharmachologic effect:
Combined drug Dolobene for external use, the action of which is due to the properties of its constituent components. Dimethyl sulfoxide has anti-inflammatory, anti-exudative (aimed at preventing release from small vessels tissue / for example, skin / protein-rich liquid discharge) and local analgesic effect due to inactivation (suppression of activity) of hydroxyl radicals and improvement of metabolic (metabolic) processes in the focus of inflammation, reducing the speed of excitatory impulses in peripheral neurons ( nerve cells), as well as the presence of hygroscopic properties (the ability to absorb moisture). Facilitates the resorption (absorption) of other ingredients of the drug. Heparin is an anticoagulant (an agent that inhibits blood clotting) direct action- has an anti-inflammatory effect, promotes regeneration (recovery) connective tissue due to the inhibition of the activity of hyaluronidase (enzyme); prevents thrombosis (formation of a blood clot); activates the fibrinolytic properties of the blood (blood clot dissolution); improves local blood flow. Dexpanthenol - a derivative of vitamin B3 - in the skin turns into pantothenic acid, which is part of coenzyme A (enzyme), which plays important role in the processes of acetylation and oxidation. Improves metabolic processes promotes the regeneration of damaged tissues.

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Compound

PRICE DOLOBENE:
Dolobene gel 20g - 31.20 UAH
Dolobene gel 100g - 63.88 UAH

main parameters

This is a clear gel medicinal substance with a characteristic odour. The components of Dolobene gel are aimed at reducing pain, swelling, inflammation, the medication is used only for external use. Belongs to a group combined drugs, it has a decongestant effect, has an anti-inflammatory effect. The drug is sold without a prescription in pharmacies, along with instructions for use.

Dolobene gel - instructions for use

It is possible to achieve a positive effect from the drug only if it is used correctly. Dolobene can only be used as an external medication, the instruction includes following rules:

1. It is necessary to apply only on the affected area of ​​the skin with a thin layer, 3 cm of the gel strip is enough for the knee joint.
2. After application, it is rubbed into the skin with light movements, it is impossible to create excess pressure on the joint.
3. It is necessary to repeat the procedure 2-4 times a day.
4. If integrity damage is present skin(crack, abrasion), then you need to apply the gel only around them, you can use the drug only on intact areas.
5. When applying, if a bandage is used, it is necessary to bandage with a material that does not allow air to pass through. The bandage must be wrapped 3 minutes after applying the gel.
6. The drug should be applied to a cleansed from contaminants, other medicines clean skin.
7. Do not allow the gel to get on open wounds, mucous membranes.
8. The duration of therapy depends on the nature and severity of the disease.

Compound

The action of Dolobene is based on a combination medicinal components. Expressed healing effect It is based on three components, which are the main active ingredients:

• dexpanthenol;
• sodium heparin;
• dimethyl sulfoxide.

Heparin improves microcirculation by preventing blood clotting. The same effect of the substance helps to increase the speed of blood flow in the damaged area of ​​​​the skin. By blocking the substance hyaluronidase, accelerated recovery connective tissue. Dexpanthenol has a catalytic effect on synthetic. The function of damaged cells, the normalization of metabolic processes.

Dexpanthenol is one of the derivatives of vitamin VZ, which has pronounced properties of an active intracellular metabolite, takes part in the reaction of acetylation, oxidation. Dimethyl sulfoxide has one of the most important properties as part of the Dolobene gel - it penetrates into the tissues of the skin, where it has an anti-inflammatory effect:

• eliminates pathogenic microorganisms;
• increases permeability vascular wall;
• relieves local pain;
• reduces the severity of edema.

Release form

Dolobene is available only in the form of a gel for external use. There is no medicine in the form of a solution, tablets or any other. Dolobene gel is sometimes mistakenly called a cream or ointment.

Pharmacodynamics and pharmacokinetics

In blood plasma, the concentration of dimethyl sulfoxide substances is normally 40 ng / ml. After applying Dolobene, after 6 hours, this figure is 120 ng / ml and is maintained for about 12 hours after the application of the medication. When using the gel for 5 days, 1 g three times a day, the following average content can be achieved:

• on the skin - 3 mg / g;
• in synovial fluid - 0.8 μg / ml;
• in the synovial membrane muscle tissues- 7-10 mcg / ml.

With external use, heparin practically does not penetrate into the systemic circulation, dexpanthenol turns into pantothenic acid, dexpanthenol has good absorption. During the first day, no more than 25% of dimethyl sulfoxide is excreted from the body, in a week - up to 48% as a metabolite, part is excreted unchanged through the kidneys. Through pulmonary system 4-6% of the total dimethyl sulfoxide is excreted in 12 hours.

Indications for use

Dolobene can be prescribed to treat a large number of conditions and diseases. The heparin component makes it a good remedy with vascular diseases, bruises and injuries. You can find the following indications in the instructions for the drug:

1. Hematomas. Helps to eliminate accumulations of blood in the cavities of the joints, subcutaneous tissues.
2. Injuries. Any production, sports. Household, which lead to bruises and other closed damage musculoskeletal system.
3. Tears, sprains, tendons, muscles, joint diseases.
4. Inflammation of the torsion of the synovial membrane (bursitis) of the articular bags.
5. Inflammation of the fasciae (tendon sheets).
6. Phlebitis. Inflammation of the walls of the veins, thrombophlebitis - an inflammatory process caused by blockage of the lumen of the vein by a thrombus.
7. Acute neuralgia peripheral nerves
8. Enthesopathy. Pathological conditions in the area of ​​attachment of muscles, ligaments to bones.
9. Varicose veins veins in the legs.
10. Treatment of trophic damage to the skin of the legs in chronic venous insufficiency.

Contraindications

Any medicine has a certain list of conditions and conditions under which the medicine cannot be used. Dolobene has some contraindications in which the use of the gel is prohibited. The list of such prohibitions includes:

1. hepatic, kidney failure. The excretion of the components and their metabolism pass through these organs. If they are not able to fully perform their function, then the use should be excluded.
2. Bronchial asthma. If there is a history of this disease, then the risk is increased allergic reaction on the main active ingredients of the drug.
3. Age under 5 years old.
4. If you are allergic to any of the ingredients.
5. Vegetative-vascular dystonia - reduced resistance vascular systems to negative impact external factors.
6. Dolobene gel and Sulindak, which is a non-steroidal anti-inflammatory drug, cannot be used simultaneously.

Method of application and dosage

Apply medication to damaged tissue 2-4 times a day or around it if there are cuts, abrasions, cracks. It is necessary to smear the gel with a thin layer, distribute it over the skin with light rubbing movements. If it is necessary to apply a bandage, it is necessary to use a material that does not allow air to pass through. It should be applied only after most of the gel has been absorbed, the alcohol (isopropanol) has evaporated from the composition, as a rule, this takes 3-4 minutes.

Dolobene can be rubbed or administered using phonophoresis (iontophoresis). Ultrasound Therapy accelerates the penetration of heparin into the skin structure. It is important to avoid contact with mucous membranes or open wounds, any damage to the skin after irradiation, dermatitis, dermatosis, etc. skin diseases, postoperative scars should not be exposed to the drug. Before applying, it is necessary to clean the skin of dirt, other medicines.

special instructions

These include the need to use the gel only on a clean surface of the skin. It is very important to avoid getting into the nose, eyes of the drug, in such a situation it is urgent to rinse the mucous membranes large quantity cold water. During the application of the gel, it is important to avoid direct sunlight on the treated areas of the skin, this can provoke the development of side effects.

Dolobene during pregnancy

It is not recommended to use the gel during childbearing, because the safety of the dimethyl sulfoxide component during this period has not been confirmed by studies and clinical trials. There are experimental data that the component has negative effect, which affects the embryonic development of the fetus, penetrates into breast milk Therefore, during lactation, the medication is also not recommended.

drug interaction

There may be side effects with the simultaneous use of several ointments with the same medicinal effect. This is especially true for the group of non-steroidal anti-inflammatory drugs. Dolobene gel tends to enhance the conductivity of other creams that are applied to the skin. For this reason, it is recommended to separate its use from the use of other products on the same area of ​​\u200b\u200bthe skin.

Side effects and overdose

According to people, the frequency of negative reactions is extremely low. Gel contains optimal amount each component, ratio active substances reduces the likelihood of side effects to a minimum. Possible negative manifestations:

1. Allergic symptoms. This is the most common type of side effect. It is noted with external use the appearance of a rash, redness of the skin, the appearance of a burning sensation, itching. Less often, there may be a change in taste sensations, an increase in body temperature.
2. Cases have been described when a complex, severe allergic reaction developed, for example, generalized urticaria, Quincke's edema.

Terms of sale and storage

You can buy Dolobene without a prescription at any pharmacy. It is recommended that you consult with your doctor before starting use so that he can evaluate the appropriateness of using the medication. After opening the tube, it must be tightly, hermetically closed with a lid. Store according to the instructions in a dark, cool place, shelf life - 3 years. Efficiency after this period will be significantly lower.

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Efficiency

Easy to find in pharmacies

Side effects

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Bruises and injuries, accompanied by hematomas and sprains, cause severe pain. liquidate quickly, through a complex effect on the center of pain is capable of Dolobene gel. This drug has a wide range of effects, allowing you to stop sharp pain damaged soft tissues. How to use it correctly and for what purposes, as well as possible adverse reactions and contraindications, we will consider further.

Pharmacological action and pharmacokinetics

Dolobene gel is complex drug , which can have the following effect on soft tissues:

• analgesic;
• regenerating;
• decongestant;
• anti-inflammatory;
• antithrombotic.

This is achieved due to the influence on the tissues of the constituent components, which, both independently and in combination, have an instant therapeutic effect. Three active ingredients, which play a key role, are capable of:

1. Heparin- creates conditions for the inhibition of the synthesis of hyaluronidase, due to which there is a pronounced regeneration of muscle fibers. It is also able to influence the viscosity of the blood, making it more liquid, reducing the likelihood of blood clots. It is well absorbed through the skin, penetrating to the site of inflammation.
2. - inhibits hydroxyl radicals involved in the formation of inflammation, swelling and pain. It also affects the conductivity of neuron endings, reducing their sensitivity. Due to this, analgesic, anti-edematous and anti-inflammatory effects are observed. Dimethyl sulfoxide, interacting with other components, is able to enhance and activate their activity, increasing the effect of the gel.
3. - is transformed in tissue cells into pantothenic acid, whose task is to restore muscle fiber, by accelerating regeneration processes at the cellular level. It is this component that allows you to reduce the duration of natural regeneration to 2-3 days.

Dolobene gel penetrates well through the skin to the focus of inflammation acting locally. First results are noticeable in 5-10 minutes when there is a marked reduction in pain, swelling and inflammation. Complete excretion of the metabolites of the drug is noted after 5-7 days from the moment the gel is applied to the skin. Absorbed in the liver and kidneys, but the concentration is negligible, which allows the use of the drug for a full and long-term treatment injuries of various etiologies.

Composition and form of release

Dolobene is produced in the form of a transparent gel, with a specific alcohol smell, in a metal tube, with a volume of 50 and 100 g.

Ask your question to a neurologist for free

Irina Martynova. Graduated from the Voronezh State medical University them. N.N. Burdenko. Clinical intern and neurologist of BUZ VO "Moscow polyclinic".

100 g of gel contains next quantity active components:

• dexpanthenol - 2.5 g;
• sodium heparin - 50,000 IU;
• dimethyl sulfoxide - 15.2 g.

Excipients:

• isopropanol;
• polyacrylic acid;
• flavors natural, in the form essential oils: pine, rosemary, citronella;
• distilled water;
• trometamol.

Application

Dolobene gel is used to eliminate the following manifestations:

• inflammatory processes of soft tissues;
• swelling;
• hematomas;
• stretching of the tendons;
• bruises;
• closed injuries with violation of the integrity of soft tissues;
• diseases accompanied by inflammation of certain parts of the body: tendovaginitis, tendonitis, bursitis, periarthritis,.

The drug can be used externally in three ways:

1. Apply evenly to the skin- apply to pre-cleansed dry skin, with soft massaging movements until completely absorbed. To do this, squeeze out the gel in the volume of a large cherry and rub it well into the sore spot.
2. Application under the bandage- necessary when a tight bandage is applied or elastic bandage(mainly with injuries of the limbs). Apply to the skin and wait for the complete evaporation of the alcohol part of the gel, only then apply a bandage.
3. Under cathode iontophoresis– a gel with good conductivity can be used in iontophoresis by placing it under the cathode (negative conductor). Electrical impulses supplied through the apparatus allow to accelerate the absorption and activation of the active components of the gel.

The duration of the course of treatment with the drug is prescribed on an individual basis, and depends on the severity and characteristics of the inflammatory process of soft tissues. In most cases, treatment does not exceed 2-3 weeks. If necessary long-term treatment and use in complex therapy to eliminate chronic diseases, a break is made every 2-3 weeks, after which the process continues.

Contraindications

In 99% of cases, Dolobene gel is well tolerated by patients, but it is categorically not recommended for the following categories of people:

• in the presence of chronic diseases of the liver and kidneys, in the acute stage;
• bronchial asthma;
• pregnancy and breastfeeding;
• children's age up to 12 years;
• individual intolerance to the components;
• Availability open wounds at the site of application, and chronic diseases skin covers.

The presence of contraindications indicates the need to consult a doctor before applying the drug to the skin. Instructions for use are not able to indicate the seriousness and danger of using the gel, in the presence of certain health problems.

With caution, you need to use the gel in the treatment of hematomas and bruises, which are located directly above the scars and old scars. Colloidal scars and skin seals (after suturing or medical staples in violation of the integrity of the skin) can become a vulnerable place for the development adverse reactions.

During the period of applying the gel to the skin, direct contact with the sun's rays should be limited, which can provoke an extensive burn.

Overdose

Data on the occurrence of an overdose of the drug are not provided by the manufacturer. Most likely, this is due to a small concentration of active ingredients that are quickly absorbed and are not capable of causing signs of intoxication.

Side effects

The most rare side reactions of Dolobene gel are:

• nausea and headache;
• lack of smell and presence in oral cavity and nasopharynx smell of garlic;
• difficulty breathing and chest cough.

Adverse reactions develop for three reasons:

1. Non-compliance with recommended dosages.
2. Use in the presence of serious diseases.
3. Applying a gel that has long expired.

The most common manifestations of adverse reactions are the following symptoms:

• redness of the skin in a limited area of ​​application of the gel;
• itching and burning;
• short-term loss of taste.

Sometimes there are cases of the development of an allergic reaction, which is characterized by the following symptoms:

• the development of urticaria not only at the site of application of the gel, but throughout the body;
• dryness and swelling of the mucous membranes;
• angioedema;
• anaphylactic shock.

The last two manifestations are deadly to humans. and require immediate elimination. They arise as a result of severe intoxication, which is caused by the release into the blood a large number cells that are seen as "enemy cells" in the preparation. To eliminate an allergic reaction, you need:

1. summon ambulance- if a person has difficulty breathing, he loses consciousness and has no signs of life. During the time that the ambulance rides, you need to do artificial respiration and indirect massage heart, and also inject 1 ampoule of adrenaline.
2. give to a man antihistamine, better to do intramuscular injection, which will allow you to get the effect much faster than the tablet will dissolve. Such drugs are suitable: Suprastin, Diphenhydramine, Diazolin.
3. Try to remove the remnants of the gel from the skin, although this is extremely difficult to do, since its alcohol base makes the drug easily carried to the site of inflammation.
4. Provide plentiful drink and bed rest.
5. Cancel the application of the gel, as well as report the fact of the development of an allergic reaction to the attending physician.

In the presence of an extensive drug allergy in remission, taking Dolobene gel is recommended in stationary conditions where, if necessary, the patient can be provided qualified assistance by taking the appropriate resuscitation steps. Before starting treatment, a test application of a small amount of gel is made, observing the development of the clinical picture.

Interaction with other drugs

The simultaneous use of the gel and other creams and ointments with a similar effect is not recommended. especially for non-steroidal anti-inflammatory drugs. Dolobene gel is able to enhance the conductivity of other applied creams, so its use should be separated from the application of other drugs on the same area of ​​the skin.

Advantages

The main advantage of the drug is its complex effect, which allows you to carry out in three directions at the same time: pain relief and removal of puffiness, elimination of inflammation, regeneration of damaged fibers and skin cells. The effect of the treatment is noted from the first application of the gel. The alcohol base freezes pain by rapidly evaporating moisture from the skin, helping to enhance the analgesic effect.

Price

Average price for Dolobene gel:

• tuba 100 g - 750 rubles;
• tuba 50 g - 330 rubles.

Terms of dispensing from pharmacies

It is available in pharmacies without a prescription, but you need to consult a doctor before using it.

Storage conditions and shelf life

After opening, the tube should be hermetically sealed with a lid. Store in a cool place for no more than 3 years from the date of manufacture. After the specified period, the effectiveness of the drug can be significantly reduced.

Analogues

Drugs with similar complex impact on soft tissue:

• Dexpanthenol - 65 rubles;

• Dioflan gel - 250 rubles;

• Venohepanol - 280 rubles;

• - 35 rubles;

• Heparin ointment - 75 rubles.

Thus, Dolobene gel has a unique complex effect on soft tissues, allowing you to quickly and painlessly eliminate bruises, sprains, hematomas and pain caused by inflammatory processes soft tissues.

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Efficiency

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Easy to find in pharmacies

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Sergey

Efficiency

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Easy to find in pharmacies

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Faina

Efficiency

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Easy to find in pharmacies

Side effects

Sergey

For removal pain attack use Dolobene gel for external use. This drug is included in the category of direct anticoagulants. The tool has a powerful analgesic, anti-edematous and anti-inflammatory effect. In addition, the use of Dolobene allows you to speed up the regeneration process and block the formation of blood clots.

The medication in question is released in the form of a gel contained in a tube for local application. The product is a homogeneous yellowish color with a strong odor.

The impact of the drug

Dolobene has a powerful anti-inflammatory effect, the drug is able to block the development of blood clots. The tool contains the following components:

• . This component normalizes microcirculation and relieves inflammation. In addition, the substance starts the process of connective tissue regeneration;
• Dexpanthenol. This substance contributes to the rapid renewal of damaged tissues, softens and relieves inflammation, and also starts the processes of epithelization. In addition, dexpanthenol is one of the constituent components of the coenzyme, which is why it takes part in all metabolic processes;
• Dimethylsulfoxide. This component is able to eliminate inflammation. It relieves swelling and has a local anesthetic effect.

Treatment with this medication eliminates swelling and improves metabolic reactions. All these properties can effectively relieve an attack of pain and alleviate general state person.

In what cases is it used

Dolobene gel is prescribed for the following negative phenomena:

1. removal of hematoma and severe inflammation;
2. severe bruises in athletes;
3. swelling on the skin;
4. inflammatory process in the area of ​​the articular bag;
5. joint injuries, sprains;
6. damage to the shoulder area;
7. fight against attacks of neuralgia.

In addition, the gel is indicated for use by persons who have received closed-type injuries.

Rules for using the medicine

First of all, Dolobene can be used exclusively on intact areas of the skin. Apply the tool as follows:

• the injured area is cleaned of contaminants;
• the remaining moisture is carefully removed with a napkin;
• apply the gel on dry and clean skin and gently rub the product in with gentle movements.

Use this remedy maybe three times a day. In this case, the frequency of application depends on how pronounced Clinical signs. After using the product, you need to wait a couple of minutes until it is completely absorbed into the skin. If necessary, it is allowed to apply a gauze bandage over the ointment. In this case, you will also need to apply a small amount of drug on the tissue itself. Before bandaging the injury site, it is advisable to wait a couple of minutes for the gel to be absorbed by the skin.

Dolobene is often prescribed for use during iontophoresis. In this case, the drug is applied under the cathode. In addition, the tool is successfully used in ultrasound therapy. This medication supplements positive effect ultrasonic waves.

As for the duration of treatment with the remedy in question, only a doctor can help the patient in this matter. The frequency of application and the course is prescribed individually, taking into account all the characteristics of the patient's body.

Contraindications

The topical medication in question can only be used with a prescription from your doctor. Dolobene has a number of contraindications. In addition, before using the product, you must read the instructions for use.

With regard to contraindications, this drug is not recommended for use in the following conditions:

1. violations of the liver and kidneys;
2. children under 5 years of age;
3. with poor blood clotting;
4. if wounds are observed in the injury zone;
5. expectant and nursing mothers;
6. with asthma;
7. if the patient has intolerance to one of the constituent components.

The use of such drugs requires consultation with a specialist. In addition, when prescribing the drug, the patient must strictly observe all medical appointments. Only in this case the patient will receive a stable positive result.

Possible side effects

If the recommendations of the doctor who prescribed the medicine are followed, negative reactions develop in isolated cases. However, they are, so it is worth describing what phenomena may occur in a patient during treatment with Dolobene gel:

• on the part of the skin, burning, itching, discomfort and rashes in the form of urticaria;
• in isolated cases, the formation of Quincke's edema is possible;
• the appearance of a pungent odor from the oral cavity.

Similar more negative reaction appear more often due to individual intolerance to one of the constituent components of the drug in question. In addition, with long-term and uncontrolled use Dolobene may also experience the above side effects.

Overdose

For achievement positive result, Dolobene is recommended for short courses. In the event that the drug is used for a long period, overdose symptoms may develop:

1. malfunctions of the liver;
2. pain in the digestive tract;
3. nausea;
4. severe headaches;
5. fatigue and weakness, becoming chronic;
6. the patient's breathing becomes very frequent and intermittent;
7. chills.

If a patient exhibits any of the above symptoms, immediate medical attention should be sought. medical assistance. This also applies to those situations when the gel accidentally got into the stomach of the patient. In this condition, it is additionally required to wash the intestines and conduct symptomatic therapy.

Use during pregnancy

Dolobene gel is the strongest topical preparation. Therefore, it is contraindicated for use by expectant and nursing mothers. This is related to the fact that clinical research regarding tolerability has not been conducted.

drug interaction

The medication in question belongs to the group of anticoagulants. The simultaneous use of Dolobene and anticoagulants with indirect effects can cause bleeding. In addition, it is not recommended to use at the same time nonsteroidal drugs as there is a risk of neuropathy.

Simultaneous use of other topical creams may enhance the positive therapeutic effect. In this case, before combining medicines, it is worth getting the advice of a specialist.

special instructions

The use of the medication in question should be agreed with the doctor. Before applying the gel, the skin area is thoroughly cleaned. When using this medication, remember the following:

• if a reaction in the form of a rash appears on the skin, therapy should be stopped immediately;
• the use of the gel enhances the photosensitivity of the skin. In view of what, during therapy, direct contact with the sun should be avoided;
• one of the main components of Dolobene is highly absorbent. Therefore, it is not recommended to combine the gel with other medicines similar in their effect;
• when applying the gel, you need to make sure that its particles do not get on the mucous area or on open wounds. If this happens, immediately wash the skin area with plenty of water. In the case when the mucous membrane of the eye is affected, you need to visit an ophthalmologist.

Dolobene should not be applied to scars, areas of skin damaged by burns, as well as on surfaces where ulcerative formations have formed.

Medicines with a similar effect

Dolobene gel cannot be called budget drug. Therefore, patients are trying to purchase an analogue with such a mechanism of action, but at an affordable cost. A good substitute for the medication in question can be Hepatrombin C. This medication contains the same components as Dolobene. However, the cost of Hepatrombin C is slightly less.

As for other analogues, they have a similar effect, but differ in composition. Among the closest analogues to the drug in question, the following can be distinguished:

1. Heparin ointment;
2. Lavenum;
3. Angioks;
4. Viatromb;
5. Clexane;
6. Lyoton 1000.

It is important to remember that before you buy an analogue, you should consult with a specialist. The point is that everyone medicinal product There are contraindications and side effects. In addition, the patient may develop an individual intolerance to the active ingredient if the gel is incorrectly selected.

Advantages

Dolobene gel has a number of advantages due to its mechanism of action. Means produces complex effect, relieves pain, eliminates swelling and blocks inflammation. Thanks to alcohol based, when applied, the pain freezes, as moisture evaporates quickly and the analgesic effect is enhanced. In addition, the drug promotes the renewal of damaged tissues and cells.