Benzydamine - a complex effect on inflammation and pain. Benzydamine hydrochloride, what is it? Side effects, drug interactions

Benzydamine is an active substance that is present in some medications, it has an anti-inflammatory effect, in addition it has an antiseptic and analgesic effect. I will consider its characteristics in more detail.

What is the action of benzydamine?

Anti-inflammatory compound Benzydamine has a stabilizing effect on cell membranes, inhibits the synthesis of prostaglandins, and also inhibits the so-called cyclooxygenase. The antiseptic activity of this substance is expressed in relation to a number of pathogenic bacteria, this also applies to Gardnerella vaginalis.

In addition, the active ingredient benzidamine has an analgesic effect. The substance easily penetrates through the mucous membranes, thereby entering directly into the inflamed tissues. This compound is excreted as metabolites in urine and stool.

What are the indications for benzydamine?

I will list the indications for the use of drugs containing benzydamine, here are some of them:

Inflammatory processes of the throat and oral cavity: pharyngitis, stomatitis, aphthous ulcers, gingivitis, tonsillitis, the so-called posttonsillectomy conditions;
Apply the remedy after radiation therapy and chemotherapy, when inflammation of the oral mucosa occurs, in addition to surgical interventions;
In violation of the work of the veins of the lower extremities, including during pregnancy;
Drugs are prescribed together with combined treatment in the presence of phlebitis and thrombophlebitis of the lower extremities;
An effective remedy after vein sclerosis, as well as after phlebectomy, in the presence of post-phlebitis syndrome;
With the so-called nonspecific vaginitis;
With fungal infections;
With trichomonas lesions;
Prescribe drugs for inflammation of the pharynx of the uterus.

In addition, the drug is used in old age, when vaginal atrophy is diagnosed in the patient's history, while the treatment is carried out in conjunction with the necessary estrogen therapy.

What are the contraindications for benzydamine?

Among the contraindications, hypersensitivity to benzydamine can be noted, in addition, the drug is not used in solution under the age of twelve, and tablet forms cannot be used in the presence of phenylketonuria.

What are the uses and dosages of Benzydamine?

There are different dosage forms of drugs, which include the substance benzidamine. A solution is used to rinse the throat and mouth, it is recommended to carry out this procedure using 15 milliliters of medication every two hours, while it is forbidden to swallow it.

Tablets should be kept in the mouth until they are completely dissolved under the action of saliva, in which case it is recommended to use the drug at 3 mg up to four times a day.

The next dosage form is an aerosol, in this form the drug is prescribed to that group of patients who, due to the circumstances, are not able to rinse their mouth. At the same time, they are used every two hours for 4-8 doses for adults, and aged 6 to 12 years - 4 doses.

Vaginal washing is recommended to be carried out twice during the day, while the powder from the bag is dissolved in 500 milliliters of warm water, 140 ml is enough for a single douching. A similar procedure is carried out in the supine position, the solution should remain in the vagina for several minutes.

Another dosage form is represented by a gel, it is used by applying it to the affected area of ​​the skin up to three times a day, after which the drug is gently rubbed until it is completely absorbed.

Any use of dosage forms of preparations containing the active substance benzidamine should be carried out after a doctor's prescription. It is worth saying that the gel cannot be applied to the mucous membranes, if the treatment will be carried out for more than one week, then you will need to consult a doctor.

With caution, drugs are used during pregnancy and lactation. Do not allow the dosage form in the form of an aerosol to get into the eyes, if this happens, then it is recommended to immediately rinse them with water, if necessary, you need to consult an ophthalmologist.

What are the side effects of benzidamine?

When using the drug, the occurrence of side effects is not excluded, among which numbness of the treated tissues can be noted, an unpleasant burning sensation develops in the oral cavity after the use of lozenges, in addition, dry mouth is noted, drowsiness joins, and allergic reactions may also appear in the form of a rash on skin.

Overdose of benzidamine

In case of oral overdose of the drug, you should immediately induce vomiting and rinse the stomach. If necessary, a specialist should be consulted.

Preparations containing benzydamine (analogues)

Tantum Verde is a drug containing benzydamine in its composition, the drug is produced in the form of an aerosol, which is intended for local use, in addition to solution and spray, as well as in the form of tablets.

The next drug is Tantum rose, it is produced in powder and in solution, it has an anti-inflammatory, antiseptic, local anesthetic effect. Effective medicine for trichomonas and fungal infections of the vagina.

Conclusion

We talked about the substance benzidamine. Instructions for use of funds in which it is must be studied by you before use! Before using these medicines, you must first consult a doctor.

Benzydamine hydrochloride - this name is known only to a narrow circle of specialists. For patients, he is familiar as Tantum Verde. Already on the second day of its use, pain, burning, discomfort in the throat decreases.

Operating principle

To remove the inflammatory reaction, prescribe drugs from the group of non-steroidal anti-inflammatory drugs.

Unlike other drugs with a similar effect (analgesics, anesthetics, antipyretics), they have several advantages:

• They act simultaneously on pain, swelling, inflammation.
• They have a wide range of applications.
• Effective for any pathology.
• They have a minimum list of contraindications.
• Do not inhibit the work of the central and peripheral nervous system.
• Do not accumulate in the body.
• Easy to use, as they are produced in any dosage forms.

Benzydamine hydrochloride belongs to the group of indazoles and, in addition to anti-inflammatory and analgesic properties, acts as an antiseptic with specific antimicrobial properties.

The main component of benzydamine hydrochloride has several distinctive qualities:

• Has a high absorption rate.
• Quickly penetrates into epithelial structures.
• Accumulating in the required concentration, it effectively acts in the focus of inflammation.
• Local use provides a low concentration of the substance in the blood, and this, in turn, makes it possible to avoid systemic effects on the body.
• Due to the ability to quickly penetrate through cell membranes, it disrupts the metabolism of pathogenic microorganisms of 110 species, inhibits their reproduction.
• It has fungicidal properties (acts on 20 strains of fungi).
• It inhibits pain receptors locally, and at the same time affects the central parts of the brain responsible for pain sensitivity.
• Shows properties in 30 seconds and keeps local anesthesia for about 2 hours.

And, most importantly: it gives a therapeutic effect on the first day of treatment.

In the modern pharmaceutical market, there are now about 40 original patented non-steroidal anti-inflammatory drugs. But only one of them with benznidamine hydrochloride. This is Tantum Verde, a product of the Italian pharmaceutical concern ANGELINI FRANCESCO A.C.R.A.F. S.p.A.

Application

All dosage forms of the drug are used topically, after meals for otolaryngological and dental pathologies:

1. Lozenges (one unit contains 3 mg of the active ingredient).
2. Solution for local irrigation and rinsing (in 1 ml - 1.5 mg) in a 120 ml bottle.
3. Spray (in 1 dose of 2.5 mg) in a 30 ml vial.

Dosage forms are prescribed for sore throat, pharyngitis, laryngitis, tonsillitis and candidiasis. In dentistry, they are used for periodontal disease, sialadenitis.

For the treatment of infectious diseases and inflammatory processes of the throat, larynx and oral cavity of various etiologies, it is recommended to use a tablet form of the drug for resorption every 6 hours.

With severe pain syndrome, rinsing or irrigation is indicated every one and a half to two hours.

A dosed spray is prescribed in one dose (one injection) from 4 to 6 times a day.

For the treatment of children, the calculation of the daily dosage of the spray (according to the instructions) is carried out according to the formula, taking into account body weight.

Tantum Verde does not include substances from the antibiotic group and dangerous auxiliary components, therefore it is actively used in the spray in pediatrics to treat babies from 3 years old.

Form advantages:

• Aerosol overdose, ingestion of the drug by a child are excluded.
• Absorption takes place gradually.
• Convenient to use at home.

Benzydamine hydrochloride is also part of the Tantum gel, which is indicated in the complex treatment of venous insufficiency. This is prescribed to patients with swelling and a chronic feeling of heaviness in the lower extremities, with nocturnal muscle cramps, pain syndrome, phlebitis and thrombophlebitis. Gel Tantum is allowed to use during pregnancy.

It is applied externally, locally to the area of ​​projection of pain or swelling, rubbing until completely absorbed four times a day.

The concern based on benzydamine hydrochloride produces the preparation Tantum Rose in the form of a powder for preparing a solution (1 sachet per 0.5 liter of water). It is used in gynecological practice in the complex treatment of bacterial vaginosis, nonspecific and specific vulvovaginitis, cervicovaginitis.

For preventive purposes, it is prescribed before and after surgical interventions, as well as for hygiene procedures in the postpartum period.

Advantages

All dosage forms with benzydamine hydrochloride meet the basic requirements for local preparations that treat acute and chronic pathologies of the oropharynx.

Advantages:

• They have a wide spectrum of antimicrobial activity.
• Do not give a systemic toxic reaction.
• Does not irritate mucous membranes.
• Hypoallergenic.
• They can be used as monopreparations and as part of combination therapy.

If the rest of the group of non-steroidal anti-inflammatory drugs are based on weak acids, then benzydamine is a weak base. Due to this, the substance penetrates well into the inflammatory focus, accumulates in the required, therapeutic concentration.

Due to the antimicrobial and antimycotic ability of the preparations, the plaque disappears, the sanitation of the mucous surfaces of the oropharynx takes place in the shortest possible time.

But, despite the fact that the drug is effective and safe for all age groups, only a specialist can make a rational choice in his favor and choose an adequate treatment regimen.

NSAIDs for topical use in ENT practice and dentistry

Active substance

Release form, composition and packaging

◊ Spray for local use dosed in the form of a clear yellow-green solution, with a peppermint aroma.

Excipients: methyl parahydroxybenzoate - 0.17 mg, ethanol 96% - 17 mg, glycerol () - 8.5 mg, peppermint flavor 27198/14 - 0.17 mg, sodium saccharinate - 0.0408 mg, polysorbate 60 - 0.0085 mg, - 0.0034 mg, quinoline dye yellow 70 (E104) - 0.0034 mg, indigotin dye 85% (E132) - 0.00017 mg, purified water - up to 170 μl.

30 ml (176 doses) - plastic containers (1) with dispenser and folding tip - packs of cardboard.

pharmachologic effect

Benzydamine hydrochloride is an NSAID, an indazole derivative, without a carboxyl group. The absence of a carboxyl group gives the following features: benzydamine is a weak base (whereas most NSAIDs are weak acids), has a high lipophilicity, penetrates well into the inflammation site along the pH gradient (where the pH is lower) and accumulates in therapeutic concentrations.

It has an anti-inflammatory and local anesthetic effect, has an antiseptic (against a wide range of microorganisms), as well as an antifungal effect.

The anti-inflammatory effect of the drug is due to a decrease in capillary permeability, stabilization of cell membranes due to inhibition of synthesis and inactivation of prostaglandins, histamine, bradykinin, cytokines, complement factors and other nonspecific endogenous damaging factors.

Benzydamine inhibits the production of pro-inflammatory cytokines, especially tumor necrosis factor-alpha (TNFα), to a lesser extent interleukin-1β (IL-1β). The main feature of benzydamine is that, being a weak inhibitor of prostaglandin synthesis, it demonstrates a powerful inhibition of pro-inflammatory cytokines. For this reason, benzydamine can be classified as a cytokine-suppressing anti-inflammatory drug.

The local anesthetic effect of benzydamine is associated with the structural features of its molecule, similar to local anesthetics.

The analgesic effect is due to an indirect decrease in the concentration of biogenic amines with algogenic properties and an increase in the threshold of pain sensitivity of the receptor apparatus; benzydamine also blocks the interaction of bradykinin with tissue receptors, restores microcirculation and reduces pain sensitivity in the focus of inflammation.

Benzydamine has an antibacterial effect due to the rapid penetration of microorganisms through the membranes, followed by damage to cellular structures, disruption of metabolic processes and the function of cell lysosomes.

It has an antifungal effect against 20 strains of Candida albicans and Candida non-albicans, causing structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction.

Pharmacokinetics

When applied topically, it is well absorbed through the mucous membranes and quickly penetrates into inflamed tissues. It is found in the blood in an amount insufficient to obtain systemic effects. It is excreted mainly by the kidneys and through the intestines in the form of metabolites or conjugation products.

Indications

Symptomatic therapy of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

• pharyngitis, laryngitis, tonsillitis;
• gingivitis, glossitis, periodontal disease, stomatitis (including after radiation and chemotherapy);
• calculous inflammation of the salivary glands;
• after treatment or extraction of teeth;
• after surgical interventions and injuries (tonsillectomy, jaw fractures);
• candidiasis of the oral mucosa (as part of combination therapy).

In infectious and inflammatory diseases requiring systemic treatment, the drug is used as part of combination therapy.

Contraindications

Dosage

Applied locally. One dose of spray corresponds to 1 click. One dose corresponds to one breath and is equivalent to 0.17 ml of solution.

Adults and children over 12 years old appoint 4-8 doses 2-6 times / day; children aged 3-6 years- 1 dose per 4 kg of body weight (maximum - 4 doses) 2-6 times / day; children aged 6-12 years- 4 doses 2-6 times / day.

The course of treatment for inflammatory diseases of the oral cavity and pharynx- from 4 to 15 days; at odonto-stomatological pathology- from 6 to 25 days; after surgical interventions and injuries (tonsillectomy, jaw fractures)- from 4 to 7 days.

When using the drug for a long time, a doctor's consultation is necessary.

Instructions for use

1. Holding the vial vertically, lift the cap tip at a 90° angle to the vial.

2. Insert the nozzle into the oral cavity and press the cap several times, according to the recommended dose. The period between two presses must be at least 5 seconds.

3. Return the nozzle to its original position.

Attention: before the first use, press the atomizer several times, directing it into the air.

Side effects

Local reactions: dry mouth, numbness, burning in the mouth.

Allergic reactions: hypersensitivity reactions, including pruritus, urticaria, photosensitivity, angioedema, anaphylactic reactions.

Others: laryngospasm.

If any of the side effects listed in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

To date, no cases of overdose of Oralcept have been reported. However, it is known that benzydamine, when accidentally ingested at a high dose (hundreds of times higher than therapeutic), especially in children, can cause agitation, convulsions, tremors, increased sweating, ataxia and vomiting.

Treatment: acute overdose requires immediate gastric lavage, restoration of water and electrolyte balance, symptomatic therapy, adequate rehydration. If the patient has taken more than the recommended dose, rinse the mouth with plenty of water. If adverse reactions occur, contact your doctor.

drug interaction

Drug interactions have not been studied.

Pharmaceutical incompatibility of Oralcept with other drugs has not been established.

special instructions

When using Oralcept, hypersensitivity reactions may develop. In this case, it is recommended to stop treatment and consult a doctor to prescribe appropriate therapy.

In the presence of an ulcerative lesion of the oropharyngeal mucosa, the patient should consult a doctor if symptoms persist for more than 3 days.

The drug Oralcept should be used with caution in patients with bronchial asthma, because. possible development of bronchospasm.

Avoid getting the spray in your eyes. If spray gets into eyes, rinse them with plenty of water.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive a car and perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions, or other activities that require increased attention.

Pregnancy and lactation

There are insufficient animal data on effects during pregnancy and lactation, adequate and well-controlled studies in pregnant women have not been conducted, and it is not known whether benzydamine passes into breast milk, therefore, the potential risk to humans cannot be determined. .

During pregnancy and during breastfeeding, Oralcept is used only after consultation with your doctor, if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Application in childhood

The use of the drug in children under the age of 3 years is contraindicated.

Terms of dispensing from pharmacies

The drug is released without a prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 4 years.

Benzydamine hydrochloride is an anti-inflammatory nonsteroidal drug that has analgesic and antipyretic properties. The active substance is present in the medicinal product in the form of benzydamine hydrochloride.

pharmachologic effect

Benzydamine is used as a local agent, as it has: decongestant, antiseptic and analgesic effect. The effect of anesthesia as a result of the use of the drug is preserved within 1.5 - 2 hours. This is due to the fact that the active substance affects not only the local nerve endings, but also affects the pain centers in the cerebral cortex.

The drug actively inhibits the reproduction of bacteria, fungi of the Candida species, which cause a large number of diseases.

The agent has the ability to quickly penetrate into the mucous membranes, is well excreted from the blood by the excretory system and through the digestive tract within 13 hours.

The result of use is noticeable during the first day of use.

Benzydamine reduces the activity of small blood vessels, normalizes the activity of organs at the cellular level. This drug has an adverse effect on the activity of microorganisms, slowing down their reproduction on the mucous membranes.

The drug reduces the sensitivity of pain receptors at the site of the inflammatory process. The special activity of this agent is manifested in relation to bacteria of the genus Gardnerella vaginalis.

Benzydamine is rapidly absorbed by the mucous membrane and actively affects the foci of inflammation.

Benzidanimine hydrochloride is prescribed for moderate pain of various etiologies for oral administration.

This drug is widely used in dentistry for the treatment of gingivitis, stomatitis, periodontitis, inflammatory diseases of the tongue. It is effective for lesions of the mucous membranes in the oral cavity, inflammation of the salivary glands, inflammatory processes after tooth extraction, fractures of the facial bones and jaw bones. It is used as an adjunct in the treatment of caries.

Benzydamine is widely used for mucosal lesions after chemotherapy. It is during this period that patients need careful analgesic treatment.

In otolaryngology, the drug is used to treat tonsillitis, pharyngitis, laryngitis. It is effective after the removal of the tonsils.

In gynecology, the drug is used to treat fungal infections, with vaginitis of various origins, trichomoniasis, inflammation of the uterus, vaginal atrophy in old age.

Benzydamine is used for the treatment of inflammation of the veins, venous stasis, thrombophlebitis, post-phlebotic syndrome, with violations of the outflow of venous blood during pregnancy. The drug can be used as a decongestant medicine.

Preparations based on benzydamine can be used both externally in case of venous insufficiency, and as part of the complex therapy of venous diseases. In patients suffering from vascular sclerosis, it is used as a wound healing and analgesic.

Locally, the drug is used in dentistry to suppress inflammation of the oral cavity, stomatitis, tonsillitis, pharyngitis, and inflammation of the salivary glands.

Contraindications and side effects

Medicines with benzydamine not recommended to use:

Benzydamine-based drugs are well tolerated by patients of any age. However when used incorrectly may be observed:

• Numbness and burning of the oral cavity;
• Redness and small rash on the skin;
• A state of weakness, drowsiness and lethargy.

Release forms

Medicinal preparations containing benzydamine hydrochloride, due to the wide range of applications, are available in various forms that are convenient for use.

• The solution is available in 120 ml vials and is used externally.
• The lozenges are greenish in color, mint flavored and square in shape.
• Spray with dispenser.
• Gel.

How the drug is used depends on the indications for use and the form of release of the drug. Dosage and regimen must be determined by the attending physician.

Tablets are used for oral administration 4 times a day. They should be completely absorbed.

The solution is used to rinse the mouth and throat. It is necessary to use one tablespoon of the solution for rinsing every 2-3 hours.

The spray is used to treat the oral cavity. The use of the spray is only permissible for adult patients and children after 6 years of age, 6 injections per use for adults and one dose for children. After using the spray, the medicine should not be swallowed.

Also, the spray is used for elderly patients and after surgery, if the patient cannot rinse his mouth on his own.

For the treatment of gynecological diseases drugs are used for vaginal douching. One packet of powder should be diluted in 0.5 liters of boiled water beforehand. For one application, 150 ml of such a solution is sufficient. The same composition is used for a one-time procedure, which should be carried out lying on its side. The liquid should remain in the vagina for some time.

Outwardly, a gel is used, which is applied to the affected area 2 to 3 times a day. Rub in with extreme caution until the product is completely absorbed. When using the gel should not get on the mucous membrane and eyes. Procedures are carried out according to the doctor's prescription within 7 days.

Use of the drug in childhood

The drug should be used with extreme caution children after 6 years. Before use, consultation with a specialist is necessary. The duration of treatment should not exceed one week.

When processing the oral cavity, the following recommendations should be observed:

• For children of school age, the spray is used after 3 hours, 4 injections per application 4 times a day.
• Children from 4 years old can use the drug at the rate of a dose per 4 kilograms of weight in three hours. The spray should not be sprayed down the throat, but behind the cheek.

Overdose

Cases of drug overdose are excluded.

Analogues of Benzydamine

The modern pharmacological industry presents a number of drugs based on benzydamine. The drug analogues are Oralcept, Tenflex, Novosept forte and Sage in the form of a solution and cough drops.

Dentists widely use such analogues as Dental paste Solcoseryl, Dentokind, Proposol spray, Kalgel, Salvin, Maraslavin and Yoks solutions, Stomatofit, Holisal, Dentaplus tooth drops.

The well-known drug Tantum Verde is also an analogue, which includes benzydamine. The drug is produced in the form of a spray and tablets. It is used topically to suppress an infection in the throat.

Tantum rose - an analogue produced in the form of a solution or powder, which has an antiseptic and analgesic effect. The drug is used in gynecological practice for the treatment of fungal infections.

Analogues, which include benzydamine hydrochloride, are a number of organotropic and gastrointestinal agents.

Included in medications

A.01.A.D.02 Benzydamine

G.02.C.C.03 Benzydamine

I.A50-A64.A59 Trichomoniasis

IX.I80-I89.I80 Phlebitis and thrombophlebitis

X.J00-J06.J02.9 Acute pharyngitis, unspecified

X.J00-J06.J03.9 Acute tonsillitis, unspecified

XI.K00-K14.K05 Gingivitis and periodontal disease

XI.K00-K14.K12 Stomatitis and related lesions

XIV.N70-N77.N76 Other inflammatory diseases of the vagina and vulva

XXI.Z100.Z100* CLASS XXII Surgical practice