Trigan d side effects. Forms of release and composition. Signs of intoxication with this drug

Introducing Pain Relief combined remedy recommended for use in spasms smooth muscle. The drug "Trigande" (tablets) is indicated for the treatment of abdominal pain, any type of colic, irritable bowel syndrome and dysmenorrhea.

In addition, it is used if necessary for short-term treatment of arthralgia, neuralgia, myalgia, after operations and diagnostic interventions, as well as in sciatica.

The medication consists of two active components, relaxing the walls of blood vessels and the gastrointestinal tract, as well as relieving inflammation and accelerating the analgesic effect. It:

• dicyclomine hydrochloride;
• paracetamol.

The drug "Trigande": instructions

Adolescents over twelve years of age and adults: 1 to 2 tablets 2-4 times a day. Reception 15 minutes before eating. It is allowed to take no more than 2 tablets at a time. Maximum daily dose- 4 pieces. At acute pain allowed intramuscular injection drug: 2 ml 4 times a day. Attention! Taking the drug should not last more than five days.

Contraindications:

• reflux esophagitis;
• obstructive diseases urinary system, hepatic tract, gastrointestinal tract;
• myasthenia gravis;
• acute bleeding;
• glaucoma;
• collapse;
• ulcerative colitis;
• diseases of the blood system;
• prostatic hypertrophy;
• violations of renal and / or hepatic functions;
• hypersensitivity to paracetamol and dicyclomine hydrochloride;
• deficiency of glucose-6-phosphate dehydrogenase;
• heart disease;
• children under 12 years of age;
• feeding and pregnancy.

Overdose

Bradycardia, loss of accommodation, drowsiness, arrhythmia, photophobia. Treatment: gastric lavage, enterosorbents, methionine inside and acetylcysteine ​​intravenously. In case of an overdose, resuscitation is carried out only in a hospital: urgently call an ambulance.

Release form

• The drug "Trigande" (tablets) - white or cream color, with a smooth surface, round shape, on one side a furrow in the middle. One blister contains twenty tablets.
• Solution for injection "Trigande" - 2 ml ampoules of 20 mg of dicyclamine. The solution does not contain paracetamol. Issued in cardboard box in the amount of five ampoules.

The drug is prescribed with caution in the hot season - due to a decrease in sweating as a result of taking Trigande (tablets), it is possible to get heat stroke, hyperthermia. Also be careful if you suffer from bronchospasm or low blood pressure. Reception strictly according to the recommendation of the doctor.

The drug "Trigande" (tablets): warning!

It is not recommended to drive a vehicle while taking the drug. Use with alcohol causes intoxication, similar to narcotic, in which hallucinations, euphoria, memory loss (short-term), coma, inadequate reactions, delirium tremens are observed. Parents, be careful what your child takes! At the first of the above symptoms, call emergency care. Before the rescue team arrives, try to induce a gag reflex and flush the stomach.

This pain reliever has combined action. Due to this, Trigan D is indicated for use in cases where the effect needs to be obtained quickly, and other medicines are powerless. medicine can be compared to narcotic substance, but if taken correctly, any side effects can be avoided.

Doctors show Trigan D for use by many patients. The speed of action of the drug is ensured by its composition. The drug is based on two main substances: dicycloverine and paracetamol. Dicycloverine is responsible for pain relief. The most effective substance copes with spasms in smooth muscles. it is added to the medication in order to accelerate and enhance the analgesic effect.

After taking Trigan, his active substances quickly absorbed and absorbed by the body. Their maximum concentration is observed after about half an hour. By this time, the patient's condition should already be normal. Most of drugs are excreted in the urine, the remains - with feces.

In what cases is Trigan indicated for use?

The medicine copes well with pain of various origins. But most effectively it eliminates discomfort occurring in the organs gastrointestinal tract.

The main indications for the use of Trigan are the following problems:

• renal, hepatic or;
• dysmenorrhea - absolutely female disease manifested during menstruation;
• irritable bowel syndrome, in which spastic contractions of the smooth muscles of the intestine are observed.

In addition, Trigan D is used for temporary anesthesia for neuralgia, myalgia, sciatica, arthralgia. The drug is also able to cope with common headaches and migraines. It is sometimes prescribed for severe toothaches and during recovery from serious diagnostic measures or surgical intervention.

Even a cold can be treated with Trigan. Paracetamol, which is part of the composition, effectively reduces the temperature in infectious and inflammatory diseases. But fit this medicine not to everyone.

The use of the drug Trigan D

Trigan should be taken orally. The dosage in each case is determined individually. But basically, doctors prescribe to drink a tablet two or three times a day. In the most difficult situations the dose is increased, and two tablets can be taken at a time. In this case, the daily dose should not exceed four pills.

If you start taking Trigan without consulting a specialist, do not forget that you can drink it regularly for no longer than five days. Those people who, for health reasons, are supposed to use the medicine for a longer period, need to control peripheral blood and regularly monitor functional state liver. In case of an overdose, the development of liver failure is possible.

Trigan D - contraindications for use

Sometimes Trigan not only does not help, but also aggravates general state. This can be avoided by knowing well the contraindications to the use of the drug. And it is prohibited when:

Like most other painkillers and analgesics, Trigan D should not be given to children under twelve years of age.

Trigan-d overdose

Complex analgesic

The active element of the drug is dicycloverine. The complementary component is paracetamol.

In tandem with the first, it significantly increases the analgesic effect and accelerates the onset of the therapeutic effect.

Basic information

It has two forms of production: tablets (20 pieces in a blister), and ampoules (2 ml in an ampoule without paracetamol). Among the inactive components are present such as calcium hydrogen phosphate, magnesium stearate, starch glycolate, as well as talc, gelatin and sugar.

Pharmacodynamics

Pain reliever, antipyretic and small degree, the anti-inflammatory effect is achieved due to the paracetamol included in the composition. The mechanism of action is associated with moderate inhibition of enzymes. The result of this is the inhibition of the process of biological synthesis of prostaglandins, which are modulators of pain sensitivity, thermoregulation, and the level of inflammation.

The active substance dicycloverine has an indirect non-selective mild m-anticholinergic, as well as a direct antispasmodic myotropic effect on the smooth muscles of the organs.

Pharmacokinetics

Active substances are well absorbed in the gastrointestinal tract. The highest concentration in the bloodstream occurs after 1-1.5 hours. The volume of distribution corresponds to 3.65 l/kg.

Paracetamol undergoes a process of metabolism in the liver. In this case, several metabolites are formed. One of them -N-acetyl-b enzoquinoneimine is able, under certain circumstances, to exert negative impact on the kidneys, as well as the liver (in particular, with a lack of glutathione in the liver or an overdose of the drug).

Close to 80% of the substance is eliminated in the urine, a small amount - in the feces.

Indications

The main purpose of taking the drug is symptomatic therapy pain in the epigastrium of various etiologies. Among them:

Due to the presence of paracetamol, it is advisable to take the medicine for colds, as an antipyretic drug.

Contraindications

There are a number of conditions in which Negative influence drugs on the body, and this is fraught dangerous consequences. Therefore, if they are present, the drug has contraindications for use. Among them:

• pathology of the urinary system, gastrointestinal tract;
• unstable state of the cardiovascular system, accompanied by acute bleeding;
• reflux esophagitis;
• glaucoma;
• severe ulcerative colitis;
• myasthenia gravis;
• explicit functional disorders kidneys and liver;
• SS insufficiency of a decompensated nature;
• prostate hypertrophy;
• individual intolerance to the components;
• pathology of the circulatory system;
• collapse;
• lack of glucose-6-pocphate dehydrogenaze;
• children under 12;
• period of pregnancy and lactation (if necessary, taking this medicine breast-feeding stop temporarily).

Caution should be given to Trigan-de in hot weather. This is due to its ability to inhibit sweating, which is fraught with the development of hyperthermia and heat stroke.

Negative impact

Side effects of the drug are associated with an antimuscarinic effect. Side effects can occur from the gastrointestinal tract, CCC, NS, visual function etc. Among them:

• difficulty in swallowing and speaking;
• vomit;
• excessive thirst and dry mouth;
• decrease in the dynamics and tone of the gastrointestinal tract;
• constipation;
• tachycardia, bradycardia;
• arrhythmia;
• dizziness;
• impaired coordination of movements;
• drowsiness;
• photophobia;
• increase intraocular pressure;
• mydriasis with loss of accommodation;
• dryness and hyperemia of the skin;
• urinary incontinence;
• inhibition of the process of hematopoiesis;
• allergic manifestations.

Circumstances of intoxication

When taking the drug, an overdose is possible not only by negligence, but also intentionally. Experiencing debilitating pain, it is likely to exceed the recommended rate or frequency of receptions.

Moreover, teenagers who are driven by a sense of curiosity mistakenly think that the drug has a narcotic effect. They combine it with alcohol or drinks with gas. This is very dangerous.

The consequences of such experiments are manifested by liver failure, a coma. In the absence of the necessary timely assistance death cannot be ruled out. This is due to the fact that paracetamol, which is part of the drug, will not allow the liver to take the drug at a dose that provides "pleasure".

Dosing regimen

The beginning of the therapeutic effect is noted after half an hour, and its peak is observed after 2 hours.

The course of therapy should not exceed 5 days.

Daily rate - no more than 4 tablets

Many do not know what will happen if you drink the drug in combination with barbiturates, antiviral agent Zidovudine, the antibiotic Rifampicin, and alcohol. Consequences are tantamount to accepting higher doses. In other words, you can get poisoned.

Symptoms

The dynamics and type of symptoms in case of an overdose will differ, depending on the cause of its occurrence. If once in increased rate take trigan-d, an overdose will be expressed:

• hyperthermia;
• chills, fever;
• convulsions and tremors all over the body;
• epigastric pain;
• decreased vision;
• nausea and vomiting;
• dizziness;
• thirst and excessive dryness of the mucous membranes of the mouth;
• blockade of muscles, followed by weakness, paresis is not excluded.

The symptoms that appear as a result of the joint use of the drug and alcoholic or carbonated drinks will resemble the condition of a person suffering from schizophrenia:

When taking the drug with alcohol - rapid heart rate

• mental overexcitation;
• mydriasis;
• rapid pulse (190 beats / min), while there is a risk of cardiac arrest;
• rapid breathing, like after a long run;
• visual and auditory hallucinations;
• memory impairment;
• inappropriate behaviour.

Help

If there are symptoms of poisoning, it is urgent to call a team of doctors. Prior to their arrival, first aid must be provided urgently.

Pre-hospital measures

During rescue operations, the victim's pulse and consciousness should be monitored. If the patient is unconscious, he should be placed on his side so that his head hangs down, but is not thrown back. This will not allow you to choke on vomit. Moreover, it is necessary to ensure that the tongue does not burn. The algorithm of actions in this case is as follows:

• rinse the gastrointestinal tract, for which drink at least 3 liters of clean water;
• provoke vomiting reflex;
• give sorbents.

If necessary, make artificial respiration and heart massage.

In a clinic setting

In the hospital, after the obligatory repeated washing of the gastrointestinal tract, the patient will be given an antidote - methionine (after 8 hours after toxemia), and N-acetylcysteine ​​(after 12 hours).

Trigan-D - industrial pharmacological drug. He is a tool that slowly "kills" mostly young people. It contains a substance that causes euphoria, and further leads to addiction.

Trigan-D - antispasmodic, combination drug, which has an analgesic effect on the body. This is due to its anticholinergic activity. It contains several components that regulate uncontrolled contractions of smooth muscles. It has antimuscarinic ability, i.e., it relaxes the walls of blood vessels and digestive system. Particularly well established in the treatment of irritable bowel syndrome.

When interacting with cholinergic receptors of the central nervous system, manifests itself as arousal. Trigan-D belongs to the group of anticholinergics, or rather m-anticholinergics. Buy medicinal product you can at the pharmacy.

Compound

Trigan-D is available in tablet form and consists of several components, these are paracetamol and dicycloverine.

Paracetamol

Non-narcotic analgesic, antipyretic (reducing body temperature). It has analgesic and antipyretic effect.

Paracetamol blocks enzymes that catalyze the biosynthesis of prostanoids or cyclooxygenase of the central nervous system. In this case, the effect occurs on the center of pain and thermoregulation. Due to this, the vessels dilate and peripheral blood flow improves. AT pure form paracetamol is not an anti-inflammatory drug.

Dicycloverine

Antispasmodic or muscle relaxant - a drug that reduces spasm, muscle tone. At the same time, it decreases physical activity. AT large doses leads to immobility.

Used in medical practice in order to reduce the hyperactivity of the gastrointestinal tract in irritable bowel syndrome, when there is a constant spasm.

In patients with glaucoma, it leads to an increase in intraocular pressure. May increase heart rate. With the wrong dose, it leads to suppression of the glands internal secretion, which is manifested by dryness of the mucosa oral cavity, respiratory tract. Expands the bronchi. Dicycloverine is harmless if not abused.

The combination of these two constituent parts Trigana-D provides the body with persistent relaxation of spasmodic muscles and relieves pain.

medical application

The spectrum of action of Trigan-D is quite large. It helps to cope with many pains.

Important! All of the above points are only help for the short-term relief of symptoms, but not a cure.

The drug disrupts the functioning of the endocrine glands, so it is very carefully prescribed for elevated temperature environment. Trigan-D reduces sweating, so overheating and heat stroke may occur. The drug is prescribed very carefully for asthmatics, because they are prone to bronchospasm.

Trigan-D as a drug

As mentioned above, this medicine is antipyretic and analgesic. But every drug has side effects, especially manifested when it is abused. Namely:

• dryness in the mouth;
• dizziness;
• violation of visual perception;
• tachycardia (rapid heartbeat);
• anemia;
• excitation;
• loss of appetite;
• vomit.

At the same time, the leading role in the occurrence of side effects is assigned to dicycloverine. It is that very “interesting” narcotic component of Trigan-D, which in normal dosages does not have a detrimental effect on the body.

Effect

Young people and teenagers, and this is usually the category that cannot afford something more expensive, have learned to use Trigan-D in order to relax or have fun.

dangerous dose this drug- approximately 10 tablets (it all depends on personal tolerance). This amount causes hallucinations and short-term memory loss.

But young people have learned to adapt to contraindications, inventing new ways of self-satisfaction:

• light - a couple of tablets with a low-alcohol drink;
• regular - 5 pieces of Trigan-D, washed down with beer;
• severe/fatal when taking 10 or more tablets of the drug, mixing it with alcoholic drinks, but not every organism can withstand such a load.
• in order to “preserve” their health, Trigan-D is purified from paracetamol (which is very destructive to the liver) and then the resulting solution is used.

The duration of the effect of such relaxation is usually 5-6 hours. It all depends on the amount of Trigan-D used as a drug.

Effects

The use of this drug in doses that do not correspond to the instructions, sooner or later will lead to serious consequences. Any violations of the prescriptions are manifested by intoxication or poisoning of the body, and poison, as you know, tends to accumulate in the body.

Symptoms of abuse of this remedy:

• decrease or loss of vision;
• atrophy and destruction of muscles;
• violation of coordination of movement;
• destruction of the liver;
• kidney stop;
• hypoglycemic coma (a sharp decrease in blood sugar levels).

Overdose and emergency care

Manifestations of symptoms of an overdose of Trigan-D in a person who accidentally or through negligence drank several tablets, and in dependent person differ.

In the latter case, these are greatly dilated pupils that do not respond to bright light, strong mental and psychomotor agitation(need to do something or run somewhere), conversation without stopping, as a rule, about nothing, incoherent speech. Severe tachycardia, breathing of a fast running person. Insane behavior in general, reminiscent of schizophrenia.

All of the above in more serious cases leads to fear, anxiety, inappropriate actions, for example, the desire to “get out” from the 9th floor (as a result of hallucinations), convulsions and seizures coma gradually develops. In very severe cases Overdose causes paralysis of the respiratory tract and death occurs.

Trigan-D contains paracetamol, and it is in large quantities is a strong blood poison. Its use leads to liver damage, and as a result develops liver failure. From severe intoxication, the kidneys stop, they simply cannot cope with the load due to vascular damage.

It is important to start by calling an ambulance. In such cases, sometimes there is no time to waste. It all depends on the condition of the patient. If a person is in an adequate condition and can perform some coordinated actions, then it is worth trying to induce a gag reflex, rinse the stomach, give an enema and give sorbents, preferably by drip.

In the case when the patient is not controlled or unconscious, before the arrival of the ambulance medical care you need to monitor his heartbeat and pressure. The position on the bed is strictly on its side and preferably face down to the floor so that it does not choke on vomit. In the event of a cessation of inhalation / exhalation, it is urgent to start doing indirect massage heart and artificial respiration.

Treatment and the introduction of antidotes (drugs that neutralize Trigan-D) are carried out only in a hospital and with the advice of a psychiatrist.

drug dependence

Two at a glance useful drug- paracetamol and dicycloverine - complement each other in Trigan-D. And this is a trap for many teenagers and young people called “addiction”. By action, the drug is similar to narcotic drugs and very quickly causes psychological and physical affection. According to doctors and pharmacists, the effect of Trigan-D is akin to that of hard drugs.

AT modern world parents, as a rule, are busy with financial matters, and children and teenagers are left alone with the street. There, "friends" will always be able to listen and understand them, who will then offer Trigan-D. It is highly addictive, so more time should be devoted to drug prevention.

And dicyclomine. Both components, acting on the body together, lead to relaxation of spasmodic smooth muscles and, thus, relieve pain attacks. Use Trigan-D for colic different localization: in the liver, kidneys, intestines. Also, this drug is prescribed for irritable bowel syndrome and pain associated with menstrual disorders.

They produce Trigan-D in two pharmacological forms: in the form of tablets and as a solution for injection. The instruction of the drug explains what dosages are recommended for adult patients and children of different age groups. Treatment with Trigan-D is not indicated for following states: myasthenia gravis; heavy ulcerative colitis; reflux of stomach contents into the esophagus, that is, reflux esophagitis; glaucoma; some vascular pathologies; individual hypersensitivity to the components of the drug. Infants in the first six months of life, pregnant women and breastfeeding mothers - this drug is not prescribed.

Side effects and overdose of Trigan-D

This tool is capable of causing quite tangible side effects such as: drying of the oral mucosa, skin; dilated pupils, accompanied by visual impairment and photophobia; crashes heart rate; a drop in the tone of the intestines and ureters, accompanied by or involuntary urination and so on. In addition, sometimes there are: vomiting, dizziness, increased intraocular pressure, allergies. Similar symptoms also occur when the recommended dosage of Trigan-D is exceeded. A person in this condition needs a gastric lavage. Activated charcoal is taken to adsorb excess drugs. This does not replace the need to seek medical attention.

Reviews about Trigan-D

If reviews about Trigan-D are left by patients who are prescribed drug treatment by a doctor, then they are, for the most part, positive. For example, one can read that it is included in the treatment regimens for irritable bowel syndrome, in which it sometimes occupies one position with No-shpa. That is, patients take one or the other remedy, depending on the strength of the spasm or individual sensitivity to the action of the drug.

However, it is difficult to find such reviews about Trigan-D - they are simply lost among the thousands of reports about the use of this drug as a drug. People who use this remedy in huge doses, often with alcohol, simply kill own liver and other body systems. It happens once in a while or every day - in any case, they irreparably destroy their own health. Unfortunately, teenagers and young people are mostly affected by this addiction.

Trigan-D - well helps to relieve pain and spasm. If you have indications for taking this drug, your doctor will probably prescribe it. However, you should not use it on your own, and even more so - in search of dubious relaxation or confusion of thoughts.

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