How long can you drink panangin. The drug Panangin: what is useful and harmful heart vitamin

To date, the shelves of pharmacies are filled with various medicines. And their range is growing rapidly. We can cure any disease that was fatal for our ancestors a couple of centuries ago with the help of pills, drops and ointments. But is everything as cloudless as it seems at first glance? Of course not. After all, almost every drug has a lot of side effects. When we treat one ailment, organs and even entire systems of our body's vital activity suffer. That is why we should treat even the most harmless medicine with extreme caution and take it only in case of emergency.

One of the clearest examples of such an effect on the human body is the medicine "Panangin". And before you find out how harmful this drug, which many people have in their home medicine cabinet, should be considered in more detail.

Clinical and pharmacological group

The drug "Panangin" is a representative of a group of drugs that restore magnesium and potassium deficiency in the body. It is most often used as a component of complex therapy for cardiac arrhythmias, myocardial infarction and heart failure. With a decrease in the content of magnesium and potassium in the diet, Panangin tablets are prescribed. Instructions for use of this medication clearly regulates the use of forms of the drug depending on the disease.

pharmachologic effect

As you know, magnesium and potassium are intracellular cations, which play a major role in the work of many enzymes, as well as the functioning of muscle contractility and strengthening bonds between intracellular structures and macromolecules. Extra- and intracellular ions of these elements contribute to the improvement of myocardial contractility. As for the endogenous aspartate contained in the preparation, it acts as an ion conductor and improves the metabolism of the heart muscle. Deficiency of potassium and magnesium in the body predisposes to the occurrence of atherosclerosis of the coronary vessels, arterial hypertension and disruption of metabolic processes in the myocardium.

Forms of release and packaging of medicines

To date, one of two forms of the drug "Panangin" can be purchased at the pharmacy: tablets or solution for intravenous administration. The first are sold in polypropylene bottles of 50 pieces. Biconvex round tablets are coated with a white film shell and have a slightly shiny, uneven surface.

The drug in the form of a clear solution without mechanical impurities is available in 10 ml glass ampoules.

The composition of the drug

The drug "Panangin" contains two main active ingredients: potassium and magnesium asparaginates. Moreover, the first is used in the form of hemihydrate, the second - tetrahydrate. As excipients for tablets, povidone, corn and potato starch, talc, as well as colloidal silicon dioxide and magnesium stearate are used. As for the film shell of the tablets, it consists of talc, macrogol 600, titanium dioxide (E171) and a methacrylic acid copolymer.

The drug solution also contains two active ingredients and water. There are no other auxiliary components in this form of the drug.

Functions of potassium in the human body

One of the most important physiological processes in which the substance is involved is the maintenance of the membrane potential of myocytes, neurons and other excitable tissues of the heart muscle. The slightest imbalance of intra- and extracellular potassium content is the cause of arrhythmia, a decrease in myocardial contractility, tachycardia, etc.

However, it is worth remembering that, like other medications, the medicine "Panangin" has side effects. Therefore, before you start taking, you should always consult with a specialist.

Why is magnesium useful?

It is impossible to clearly answer the question of what is the main task of this substance in the functioning of the vital systems of the body. After all, potassium is one of the most important cofactors in more than 310 enzymatic reactions, such as the synthesis of nucleic acids and proteins, as well as energy metabolism.

Magnesium also has a positive effect on the cardiovascular system: it reduces the contractility of myocytes of smooth muscle tissue of arterioles. This effect leads to the normalization of coronary blood flow and vasodilation. As a result, heart rate improves and myocardial oxygen demand decreases. In other words, magnesium has an anti-ischemic effect on the tissues of the heart muscle.

Who is prescribed the drug?

For those who do not know what the Panangin tablets are from, it is worth saying that they are prescribed to compensate for the deficiency of magnesium and potassium, provided they are low in the diet.

Less often, the tablet form of the drug can be recommended for patients as part of the complex treatment of arrhythmia, heart failure and acute myocardial infarction. In most cases, people with such diseases are prescribed the drug "Panangin" in the form of a solution for intravenous administration.

Assign a solution or tablets "Panangin" (the instruction also contains this information) to people suffering from various heart diseases. This is due to the fact that potassium and magnesium ions improve the tolerability of cardiac glycosides.

Doses and method of administration of tablets

The doctor who prescribes the drug should tell the patient how to take Panangin. But, unfortunately, not all doctors perform their work efficiently and conscientiously. In this case, the patient should carefully read the information about the drug and only then take the medicine "Panangin". Instructions, reviews will help a lot in this.

Assign the drug for 1-2 tab. 3-4 times a day, but you should know that the maximum daily dose should not exceed 9 tablets. It is better to take the medicine a couple of minutes after eating, since the acidic environment of the stomach can significantly reduce its effectiveness. As for the duration of therapy and repeated courses of treatment, they should be determined only by the doctor, taking into account the individuality of each patient. Otherwise, if the patient takes Panangin without a doctor's prescription, side effects can be very serious.

Preparation and application of the solution

If the drug is prescribed to the patient by drip, the rate of administration should not exceed 20 drops per minute. In especially severe cases, repeated administration is possible after 5-6 hours. But such therapy is possible only under the supervision of doctors in a hospital setting.

To prepare a solution for intravenous infusion, the contents of 1-2 ampoules are dissolved in 50-100 ml of glucose. The ratio of the solvent and the dose of the drug is selected individually by the doctor.

Overdose and first aid

If the patient does not know how to take Panangin and does not bother to read the instructions, the consequences of such treatment in the form of hyperkalemia and hypermagnesemia will not take long. That is, within a short time after taking excessively high doses of the drug, the patient may experience symptoms such as myasthenia gravis, fatigue, confusion, paresthesia. With an overdose of potassium, the risk of cardiac arrhythmias increases several times, which can manifest itself in the form of arrhythmia, bradycardia, and even cardiac arrest.

If you exceed the permissible dose of the drug and do not know what side effects the Panangin drug has, the clinical picture of an overdose of potassium may be supplemented by symptoms of hypermagnesemia. In this case, the patient shows a decrease in muscle excitability and blood pressure, vomiting. If the magnesium content increased sharply, that is, a person exceeded a single dose of the drug by 2-3 times, there is a high probability of developing respiratory paralysis, inhibition of tendon reflexes and even coma.

Regardless of the reason for the overdose, how much the permissible dose was exceeded, the patient must immediately receive first aid. For this, a calcium chloride solution of 100 mg / min should be injected intravenously. In especially difficult cases of overdose, peritoneal dialysis and hemodialysis are indicated.

drug interaction

Even those who know what the Panangin tablets are from are interested in information about which medications it can be taken in combination with.

Simultaneous use of the drug with beta-blockers, potassium-sparing diuretics, heparin, ACE inhibitors, cyclosporine can cause the development of hyperkalemia. And, as you know, this can lead to the appearance of asystole and arrhythmia.

It is also worth noting that preparations containing calcium significantly reduce the effect of magnesium.

Has a remedy "Panangin" and contraindications to the simultaneous use with dexamethasone, atracurium and suxamethonium, as the risk of increased neuromuscular blockade increases.

As for enveloping and astringent agents, it is worth knowing that they slow down the absorption of the active ingredients of the drug in the gastrointestinal tract. Therefore, if there is a need for the compatibility of these drugs, the 3-hour interval should be strictly observed.

But at the same time, it is not only possible to use cardiac glycosides, but it is also recommended with the Panangin solution. The compatibility of these drugs is due to the fact that potassium and magnesium enhance the effect of drugs of the glycosidic structure and reduce their undesirable effect.

Contraindications

Like any other drug, Panangin is a medicine that has its own list of contraindications.

The tablet form of the drug is strictly forbidden to be taken by people suffering from chronic and acute renal failure, as this can aggravate the course of the disease and lead to serious consequences. Has a remedy "Panangin" contraindications for patients with hyperkalemia and hypermagnesemia, as well as severe myasthenia gravis.

The reason for refusing to use the drug can be a violation of amino acid metabolism, dehydration, acute metabolic acidosis, hemolysis and Addison's disease.

The solution "Panangin" contraindications are much wider. In addition to the above, include dehydration, lactation, pregnancy, age up to 18 years. Moreover, it is forbidden to use this form of the drug for people with insufficiency of the adrenal cortex.

Side effects of "Panangin"

It is almost impossible to predict the body's reaction to any of the components of the drug, so the instructions contain a list of all possible manifestations.

So, the digestive system can react to Panangin tablets with nausea, diarrhea, vomiting, discomfort in the pancreas.

On the part of the water and electrolyte balance, the development of hyperkalemia and hypermagnesemia is possible, which are accompanied by paresthesia, thirst, hyporeflexia, convulsions, decreased blood pressure and depression of the respiratory center.

If you quickly in / in the solution "Panangin", side effects, in addition to hyperkalemia and hypermagnesemia, may be supplemented by phlebitis, AV blockade and a paradoxical reaction.

Terms and conditions of storage

Since the drug "Panangin" is quite dangerous, it should be stored out of the reach of children at a temperature of 15 to 30 ° C. As for the expiration date, it is indicated on the packages of the medicine: for a solution - 3 years, and for tablets - 5 years.

Minerals play a huge role in the human body. In case of their shortage, a person's condition can significantly worsen, and in the future, a disease, including hypertension, can form.

To avoid this, doctors very often prescribe Panangin, which restores the necessary amount of magnesium and potassium, and also supports heart health.

How to take Panangin? Instructions for use, at what pressure it is rational to use the drug and other nuances of its use in the article.

Panangin reduces pressure or not? The drug in its composition simultaneously contains potassium and magnesium ions. These two micronutrients are related, because in the case of a deficiency in the body of potassium, magnesium is usually also lacking. Therefore, most often, simultaneous correction of the level of these minerals, which are so necessary for the normal functioning of the body, is required.

Tablets Panangin

Potassium is needed to maintain the membrane potential of myocytes, neurons, and other cells of myocardial tissue. If there is a deficiency of this element, then there is a high probability of a violation of myocardial contractility, rhythm, sequence, frequency of contraction and excitation of the heart muscle.

Magnesium is involved in more than 300 enzymatic reactions. Muscle contraction, also cardiac, DNA and protein synthesis, nerve impulses - all these processes occur with the active participation of magnesium. This trace element has a positive effect on the heart muscle, reducing the likelihood of thrombosis, reducing the amount of accumulated cholesterol in the arteries. This action is provided due to the ability of magnesium to normalize the heart rhythm, nourish the heart muscle, and improve blood flow.

Panangin improves the functioning of the heart muscle, improves its work, strengthens, normalizes the metabolic processes occurring in the myocardium. In addition, the drug prevents the occurrence of atherosclerosis, arrhythmia, coronary heart disease, hypertension.

Indications for use

The therapeutic goals of Panangin are as follows:

• heart rhythm disturbances that arose due to intoxication with digitalis products;
• arrhythmia resulting from electrolyte disturbances;
• violations of the rhythm of the atria, ventricles of the heart;
• arterial hypertension;
• coronary insufficiency.

In addition, the concentration of potassium and magnesium should be replenished by athletes and people who have heavy physical exertion, lovers of saunas and baths, those who adhere to strict diets. Panangin for hypertension is also used for complex therapy in the case of taking diuretics, glucocorticoid hormones, sedatives, as well as for the treatment of diseases of the gastrointestinal tract.

Release form and composition

The release form of Panangin is of two types - injection and tablets.

There are two active ingredients in the preparation, namely:

• potassium aspartate, which in 1 ml of solution contains 45 mg, and in 1 tablet 158 ​​mg.
• magnesium aspartate, the volume of which in 1 ml of solution is 40 mg, and in 1 tablet 140 mg.

As for auxiliary agents, the following can be distinguished in the composition: povidone, magnesium stearate, potato, corn starch, talc, titanium dioxide, colloidal silicon dioxide, macrogol 6000, methacryric acid copolymer.

The tablets of the substance have a biconvex surface, their shape is round, the color is white. Packed tablets of 50 pieces in a plastic bottle. The solution for injection also contains water. It is colorless, transparent. It is in a 10 ml ampoule. Ampoules are placed in a cell package of 10 pieces.

Contraindications

Contraindications include some physiological and pathological conditions of the body, namely:

• Addison's disease;
• renal failure (chronic and acute);
• hypermagnesemia, hyperkalemia;
• severe myasthenia gravis;
• cardiogenic shock;
• atrioventricular blockade of 2-3 degrees;
• violation of amino acid metabolism;
• metabolic acidosis;
• hemolysis;
• hypersensitivity to components.

In addition, it is extremely careful to take the drug during pregnancy, regardless of the period, as well as during breastfeeding. It should not be used by people with adrenal insufficiency, persons under 18 years of age. Reception may be contraindicated in diseases of the liver and kidneys, atrioventricular blockade of the 1st degree. In continuation of the question of whether Panangin raises or lowers blood pressure, Panangin should not be taken at low pressure.

Although a heart drug is often prescribed for prevention, however, due to the presence of a large number of contraindications, you should consult a specialist before using it.

Side effects

Such a drug is well tolerated by the body. But the occurrence of side effects is not excluded.

In the case of an injection, side effects may be of the following nature:

• symptoms of hyperkalemia such as diarrhea, vomiting, paresthesia, nausea;
• symptoms of hypermagnesemia, namely: redness of the face, convulsions, thirst, decreased pressure, respiratory depression;
• paradoxical reaction;
• atrioventricular block;
• discomfort in the epigastric region.

If you quickly enter the solution for injection, then side effects of the following nature may also be observed:

• skin hyperemia;
• pressure drop;
• hyperkalemia and hypermagnesemia;
• phlebitis;
• paradoxical response.

Instructions for use

Since the answer to the question of whether Panangin reduces blood pressure, the answer is positive, as a rule, no more than 1-2 tablets per day are prescribed so as not to bring down blood pressure until you feel worse.

The maximum allowable daily dose is 9 pieces, which means that you can drink no more than three tablets at a time. The duration of treatment depends on the tests and is prescribed on the basis of them by the doctor.

The solution is used intravenously drip, using 1-2 ampoules at a time. To prepare it, you need to dissolve the contents of the ampoule in a 5% glucose solution with a volume of 50-100 ml. Re-introduction is allowed after 4-6 hours.

An acidic gastric environment can reduce the effectiveness of the drug, so it must be taken strictly after meals.

drug interaction

As already mentioned, the drug should be taken only after consulting a doctor.

At the same time, it is very important to inform him about other medicines that you use, since Panalgin can interact with them and harm the body.

When using iron salts and Tetracycline, sodium fluoride, this drug inhibits their absorption. In this regard, it is necessary to make an interval between doses of at least 3 hours.

Hyperkalemia may develop as a result of the simultaneous use of potassium-sparing diuretics or. Therefore, it is essential to monitor the concentration of potassium in the blood. Neuromuscular blockade can be triggered by the parallel use of Decamethonium, Suxamethonium, Atracuronium, Succinyl chloride. The concentration of magnesium is increased by taking Calcitriol.

Overdose

There were no cases of overdose with Panangin. If the recommended dose is exceeded, the manifestation of hyperkalemia and hypermagnesemia is likely. As treatment, symptomatic therapy is carried out.

Panangin is a drug that is often prescribed to people with a lack of potassium or magnesium.

Most often, the indications are not related to the age group, so it can be taken at any age, taking into account the indications of the doctor and the composition of the medication.

The drug enters the bloodstream and reacts with substances that are involved in metabolism. It also observes the therapeutic effect of the drug, depending on the composition and form of release.

Release form

The medicine is sold only if there are indications for its use, as well as a prescription from a cardiologist. There are reviews of patients who bought the medicine of their own free will. It can be taken independently if the treatment is provided at home.

There are tablets and ampoules of the drug. You need to store it in a dark place out of the reach of children. It is desirable that the temperature in the room does not exceed 25 degrees. The packaging of the drug is white with a blue name.

All dragees are not in a blister, but in a vial. The lid has child protection. Panangin costs from 600 to 800 rubles, depending on the seller and pharmacy.

The composition includes: 0.157 g of potassium and 0.13 g of magnesium. In the preparation for intravenous use there is an instruction; composition - 0.01 ml accounts for 0.45 potassium, 0.4 g magnesium.

The composition of aspartate corresponds to the number of elements, like 11 mg of magnesium and 36 mg of potassium in a dragee. The ampoule, based on a pure product, has a composition of 104.3 mg of potassium and 34.7 mg of magnesium. Substances are prescribed when calculating ions.

Since this product belongs to a pharmacological group that affects tissue turnover, it affects the exchange process between the tissues of the heart muscle and the underlying connective tissues.

Features of prescribing a medication

There are indications when the drug is prescribed in cases where there are problems with the rhythm of the heartbeat.

There are patient reviews indicating that the drug did not help, so you should consult a doctor before taking it.

Also, if a failure in the rhythm of the heart is detected due to intoxication of the body, digitalis poisoning, or the fact of atrial fibrillation of the heart is established, Panangin is prescribed. Additionally, the doctor's testimony gives the right to use it as a prophylactic agent that helps to eliminate disturbances in the area of ​​abnormal atrial rhythm and paroxysm in this area.

Panangin: instructions for use states that the drug can be prescribed in the treatment of coronary insufficiency, if there are indications of violations in the area of ​​\u200b\u200bthe required amount of oxygen and its delivery to the heart muscle.

With it, you can reduce the disturbances caused by myocardial metabolism in case of a decrease in the level of potassium in the blood. It also helps to avoid negative reactions after the use of diuretics, which remove sodium and chlorine from the body.

Features of treatment

Symptoms of tachycardia are not a disease, but only a sign indicating a predisposition to heart disease and vascular heart disease. Heart palpitations are amenable to preventive and outpatient treatment, as a consequence.

Depending on the type of tachycardia and its type, various combined methods of treatment using Panangin may be prescribed.

The tactics of appointment and treatment are prescribed by the cardiologist after collecting all the necessary patient tests.

Exists. It can be attributed to the ventricular form. In this case, apply immediate treatment with this drug. If it is established that there is a paroxysmal tachycardia, the treatment is carried out in a hospital and the drug is prescribed in ampoules. Less often, the drug is used as the main method of treatment when a sinus type of disease is detected. Numerous patient reviews show that there is an improvement in the condition when taking the medication in the form of tablets.

The effectiveness of the drug depends on the type of treatment. Those who are used to self-medication will not be able to properly feel the benefits of the medication.

During pregnancy

If a pregnant woman has heart problems and shortness of breath, Panangin is not prescribed. In extreme cases, it is applicable in minimal doses in the 2nd and 3rd trimester. During lactation - prohibited.

If there is an urgent need to use the remedy in the first trimester, the cardiologist is obliged to collect blood for tests and identify predisposition and allergic reactions to the elements contained in Panangin.

With a positive result, it is necessary to find analogues that can be prescribed to a pregnant woman with the least harm.

Some reviews of pregnant women say that the remedy really helps to get rid of arrhythmias during the first week.

As a rule, the average daily dose for an ordinary person is 2 tablets three times a day. For pregnant women, this practice is limited to ¼ tablets twice a day, and ¼ tablets 1-2 times a day in the first trimester. Take orally only after meals, as the acidic environment of the stomach reduces the effectiveness of the available substances.

children

Children are prescribed analogues that contain up to 70% of the elements, as in Panangin.

In extreme necessity, when paroxysmal tachycardia is detected, children are given ½ tablet 1 time per day. In this case, it is necessary to monitor the dynamics of improvement only in the hospital.

If there are no changes, the medication is increased in dose, and you need to take twice as much. If the dose of the permissible value has been exceeded, calcium chloride is administered intravenously until the overdose symptoms disappear - conduction disturbance.

Contraindications

It is forbidden to take the medicine if you have one of the following signs of illness:

1. Hypersensitivity to one of the substances in the product.
2. Kidney disease and deficiency.
3. Increased potassium content in the body.
4. Increased content of magnesium in the body.
5. Addison's disease.
6. AV block of the first and third degree.
7. Impaired amino acid metabolism.
8. Hemolysis.
9. Acidosis of the last stage.
10. Dehydration, weakness.

You also need to take into account the individual characteristics of organisms and monitor the rejection of Panangin substances.

Combination of medication with others

Panangin can give the following reactions when interacting with substances of other products, namely:

• Cyclosporine, adrenoblockers, heparin, ACE inhibitors - if taken together, causes complications and the possibility of developing asystole.
• Glucocorticosteroids - the combination of substances leads to the disappearance of hypokalemia, which is increased by taking a steroid.
• Glycosides - the potassium contained in Panangin will not give side effects and treatment in principle.
• Antiarrhythmic drugs - the combination with Panangin leads to the assimilation of negative dromotropic absorption into the blood of the last free substances that are responsible for the direct work of the heart muscle.
• Neomycin, Tetracycline - the combination helps to minimize the effect when taking antibiotics.
• Anesthetic - together with Panangin, it can worsen the effect of both drugs on the human nervous system.

Since Panangin contains such substances, the combination with which elements of other medicines can lead to undesirable consequences, it should be noted that there are analogues of Panangin.

Varieties

Below is a table of analogue medicines similar in properties and structure to those medicines that can be used instead of Panangin.

Maxim, 9 years old, mother brought her son to the doctor with complaints of shortness of breath and shortness of breath. Previously examined by a cardiologist - the diagnosis was "tachycardia". The child is taken for an ultrasound of the heart and ventricles, a Doppler image is examined. Identified symptoms of abnormal work of the heart. Sweaty palms during examination and excitement.

The cardiologist did not determine the presence of noise. When examining the fundus, the retina and fluid are normal. Noise is heard while listening.

A cardiologist prescribes treatment in a stationary mode. Of the substitutes, Panangin is prescribed in the amount of 2 tablets after meals 3 times a day. After three days, a second study is done - the heart rhythm returns to a normalized and correct rhythm. Arrhythmia occurs only during experiences.

A week later, with a re-examination and identification of positive dynamics, the boy can be sent home with the preservation of treatment until the end of the third week. The full course lasts 1 month with the same dosage.

Feedback from doctors and patients

Svetlana, Tuapse, 2014. My review is for those who do not self-medicate, but are examined by doctors and only then treated!
My child has cerebral palsy (infantile cerebral palsy) and epilepsy. There is a concomitant disease "myocardial dystrophy", which doctors diagnosed at birth along with other sores. We regularly received treatment at the children's clinical hospital in Krasnodar.

In the next exacerbation, the cardiologist prescribed "Panangin", because the child was constantly on hormones, there was shortness of breath. Hormones are known to flush out potassium and magnesium and put a strain on the heart.

Since the child is disabled, and we have the right to benefits when buying medicines, we were given asparks, after taking the child, rashes began, allergies began. Then I, after all, bought Panangin at the pharmacy. I will tell you that the difference in price is tangible for Panangin - 150 rubles, and for Asparkam only 20 rubles.

But "Panangin" came up, immediately shortness of breath became less, there was no blueness around the nose and lips, the child began to sit up in bed on his own, which was not there before (shortness of breath immediately appeared), perked up.
Our course lasted one month. When it is necessary to continue treatment, it is individually decided by the doctor. Doses are also selected by the doctor. Do not be ill!

Elena, Yekaterinburg, 2012. The autumn-winter period turned out to be difficult for me. Worried a lot. As a result, unpleasant sensations began to arise in the heart: as if it were missing beats, it became creepy and scary. All this was accompanied by cramps in the legs.

I went to the doctors, they did a cardiogram and blood for electrolytes. Some indicators were at the lower limit of the norm. The doctor prescribed Panangin.
My grandmother drank it, so I got the impression of near old age.

But everything worked out, with "Panangin" I realized that if the drug is chosen correctly, then there will be enough strength for a lot more! Soon it will be a month since I take it. The main heart works correctly, the mood has improved.

I was pleased with the low price - 135 rubles, the European manufacturer Gedeon Richter is also reliable, there is protection for the medicine from fakes.
If there is a doctor's appointment, I recommend taking a course, it helped me from arrhythmia.

Julia, Chita. year 2014. I use Panangin for the second or third time. It all started with the fact that it began to reduce the calves of the legs, rummaged through the Internet and found that this happens when there is little magnesium and potassium in the blood. It got to the point that the calves were cramping, almost every night. "Panangin" turned out to be just a miracle! Even the first dose saved me from cramps. The twisting pains no longer woke me up at night, and I didn’t have to stand on the cold floor waiting for them to end.
All my ordeals have stopped.

I usually take 2-3 tablets a day. I took it until the convulsions stopped, which means that the body accumulated trace elements.
The heart does not hurt, so I can’t say anything about how he helps him. But it works wonderfully on the muscles. I think it's just a find. The only drawback is the smell from the jar of medicine - some kind of fish.

Anastasia Voronezh 2010. The main components of "Panangin" are potassium and magnesium, I think that's why it is not dangerous for pregnant women. Personally, it helps me with cramps. If you consume a lot of cereals, dried fruits and nuts, then you can reduce the intake to one tablet per day, there is unlikely to be an overdose. My doctor prescribed one three times, and the daily requirement of magnesium for pregnant women is 0.45 grams, in one tablet of "Panangin" - 0.14 grams (it should also be clarified in the annotation). I'm afraid to take 4 tablets, an overdose can lower blood pressure, cause drowsiness and weakness.

Maria Olegovna Shenker, cardiologist, therapist."Panangin" improves metabolic processes in the heart muscle, therefore it is recommended for exercise and active sports.

Nevmerzhitsky G.I., cardiologist. For 28 years of work as a doctor in a cardiological clinic, I was convinced that timely examination and correctly prescribed treatment play a paramount role for health.

According to studies in people who died from a heart attack, the content of magnesium and potassium in the heart muscle is almost halved. Their deficiency is the cause of arrhythmias, which can be fatal.

My medical career began in the mountains of Kazakhstan. In conditions of lack of oxygen (hypoxia), a thickening (hypertrophy) of the myocardium is formed, which eventually leads to heart failure.

In such situations, when the heart muscle experiences oxygen "starvation", it is important to take drugs that restore the disturbed balance of essential trace elements. It is Panangin that is the ideal solution in such situations. The conclusion is based on my experience.

We have been using Panangin for the treatment of patients with myocardial infarction for more than a year.
In patients with rhythm disorders, adequate doses and regular intake give good results after a few days.

We often heard that the deficiency of magnesium and potassium can be compensated by food. Special literature says the following: it is enough to increase the dosage of potassium by 391 mg per day, as the risk of stroke is reduced by 40%.

These two necessary elements normalize the rhythm of the heart, improve its contractility. In my experience and the opinion of colleagues, the course of treatment with Panangin reduces blood viscosity and reduces the risk of thrombosis, and slows down the growth of atherosclerotic plaque. Therefore, even the most complete nutrition will not replace the drug. For the prevention and treatment of cardiovascular pathology - "Panangin" is a unique drug that can effectively regulate metabolic processes in the muscles.

Yulia Karpova, Dnepropetrovsk city, cardiologist. From my practice as a cardiologist, I see the expediency of using Panangin for athletes under stress, for the elderly in the summer heat and for patients living in mountainous areas.

According to the analysis of mortality, the number of deaths increases by 2.5 times during the summer heat. In the blood, the amount of sodium increases, and magnesium decreases - this is how the body adapts to the heat. For heart patients, such a restructuring is fraught with thrombosis and an increase in signs of heart failure. A decrease in potassium levels causes a heartbeat, an arrhythmia occurs.

Our practical experience made it possible to make sure that taking "Panangin" during an increase in the rhythm caused by heat and stress significantly leads to a slowdown in heart rate.
This is confirmed by our small study. We took 60 patients with hypertension, half of them (30 people) for the purpose of prevention received "Panangin" tablet three times a day throughout the summer. As a result, according to the blood test, the level of microelements in this group of patients increased.

What did it give them? They were less likely to experience pressure surges, their mood improved. They were more active than the group that did not receive the drug. Our observation demonstrated that Panangin, taking into account its contraindications, can be successfully used in patients with cardiovascular diseases, especially during unfavorable periods.

Maylyan Anzhela Igorevna, cardiologist, Donetsk. We have been using Panangin in our practice for more than a dozen years. It is a mandatory drug for violation of electrolyte metabolism, which is easy to detect by blood tests.

It helps with tachycardia and rhythm disturbances of unknown origin in young people against the background of low pressure. If people come to our department whose work is associated with hard physical work or workers in hot shops with complaints of heartbeat or rhythm disturbance, then first of all I prescribe the injectable Panangin, then a course of tablets for another 2 weeks.

Dehydration caused by persistent vomiting, alcohol poisoning, and taking diuretics also leads to electrolyte disturbances and disruption of the heart rhythm. Rescues "Panangin".

Maslikhova Lyubov Vasilievna, general practitioner, Mariupol. Often, work on the site does not allow you to check the balance of electrolytes in the blood, especially in elderly or bedridden patients. The empirical appointment of "Panangin" helps to identify a rhythm disorder associated with a lack of vital trace elements. I use therapeutic doses, then the drug will not cause harm to people with a normal level of trace elements.

I do not prescribe "Panangin" to patients with chronic renal failure or with an allergy to the drug. Also, if it is not possible to achieve normalization of the rhythm or removal of convulsions after a week or two, I do not recommend exceeding the daily dosage of the drug. An excess of trace elements, as their lack, leads to rhythm disturbance.

A drug that replenishes the deficiency of potassium and magnesium in the body

Active ingredients

Magnesium aspartate (potassium aspartate & magnesium aspartate)
- potassium aspartate (potassium aspartate & magnesium aspartate)

Release form, composition and packaging

◊ Film-coated tablets white or almost white, round, biconvex, with a slightly shiny and uneven surface, almost odorless.

Excipients: colloidal silicon dioxide, K30, magnesium stearate, talc, corn starch, potato starch.

Shell composition: macrogol 6000, titanium dioxide (E171), butyl methacrylate, dimethylaminoethyl methacrylate and methacrylate copolymer, talc.

25 pcs. - blisters (2) - packs of cardboard.
50 pcs. - polypropylene bottles (1) with control of the first opening - packs of cardboard.

pharmachologic effect

The most important intracellular cations potassium and magnesium play a key role in the functioning of many enzymes, in the formation of bonds between macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects myocardial contractility. Endogenous aspartate acts as an ion conductor: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Potassium and magnesium aspartate improves myocardial metabolism. The lack of potassium and / or magnesium ions predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium. The intake of potassium and magnesium aspartate allows you to compensate for the lack of these electrolytes in food.

Pharmacokinetics

Magnesium

The total supply of magnesium in a human body weighing 70 kg averages 24 g (1000 mmol); more than 60% of magnesium is found in bone tissue and about 40% in skeletal muscles and other tissues. About 1% of the total magnesium reserve in the body is in the extracellular fluid, mainly in the blood serum. In healthy adults, the content of magnesium in the blood serum is in the range of 0.7-1.10 mmol / l.

Magnesium is absorbed from the gastrointestinal tract by active transport. The kidneys are the main regulator of magnesium balance in the body. 3-5% of ionized magnesium is excreted by the kidneys.

An increase in urine volume (for example, during loop diuretic therapy) leads to an increase in the excretion of ionized magnesium. If absorption of magnesium in the small intestine is reduced, subsequent hypomagnesemia leads to decreased magnesium excretion (<0.5 ммоль/сут).

Potassium

The total supply of potassium in a human body weighing 70 kg averages 140 g (3570 mmol). The total potassium reserve is somewhat less in women than in men, and decreases slightly with age. 2% of the total potassium in the body is outside the cells, and the remaining 98% is inside the cells.

Potassium is absorbed in the gastrointestinal tract. The optimal intake of potassium with food is 3-4 g (75-100 mmol) / day. The main route of potassium excretion is renal (about 90% of potassium is excreted by the kidneys daily). The remaining 10% is excreted through the gastrointestinal tract. Thus, the kidneys are responsible for long-term potassium homeostasis, as well as for the potassium content in the blood. In the short term, the potassium content in the blood is also regulated by the current of potassium between the intracellular and extracellular spaces.

Indications

To eliminate the deficiency of potassium and magnesium as part of combination therapy for:

- various manifestations of coronary heart disease (including acute myocardial infarction);

- chronic heart failure;

- heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).

Contraindications

- hypersensitivity to any of the components of the drug;

- acute and chronic renal failure;

- hyperkalemia;

- hypermagnesemia;

- Addison's disease;

- AV blockade of I-III degree;

- shock, including cardiogenic (BP less than 90 mm Hg);

- violation of amino acid metabolism;

- severe myasthenia gravis;

- hemolysis;

- acute metabolic acidosis;

- dehydration;

- age up to 18 years (efficacy and safety have not been established).

Carefully: pregnancy (especially in the first trimester) and the period of breastfeeding.

Dosage

Before use, the patient should consult a doctor.

Inside, without chewing and drinking plenty of water. The drug should be used after meals, because. the acidic environment of the stomach reduces its effectiveness.

The usual daily dose is 1-2 tablets. 3 times / day. The maximum daily dose - 2 tab. 3 times / day.

The duration of the drug and the need for repeated courses is determined by the doctor.

Data on the safety and efficacy of the drug in children and teenagers missing.

Side effects

From the digestive system: possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastrium (in patients with anacid gastritis or cholecystitis).

From the side of the cardiovascular system: possible AV blockade, paradoxical reaction (increase in the number of extrasystoles).

From the side of water and electrolyte balance: possible hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (flushing of the face, thirst, lowering blood pressure, hyporeflexia, respiratory depression, convulsions).

If any of the listed adverse reactions become serious or adverse reactions occur that are not listed in the instructions, the patient should consult a doctor.

Overdose

The risk of symptoms of hyperkalemia and hypermagnesemia increases.

Symptoms of hyperkalemia: fatigue, myasthenia gravis, paresthesia, confusion, rhythm disturbance (bradycardia, AV blockade, arrhythmias, cardiac arrest).

Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure. With a sharp increase in the content of magnesium ions in the blood - inhibition of deep tendon reflexes, respiratory paralysis, coma.

Treatment: symptomatic therapy - in / in the introduction at a dose of 100 mg / min, if necessary - hemodialysis.

drug interaction

Pharmacodynamic interaction

Combined use with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs increases the risk of developing hyperkalemia up to the development of arrhythmia and asystole.

The simultaneous use of potassium preparations with GCS eliminates the hypokalemia caused by the latter.

Potassium reduces the undesirable effects of cardiac glycosides.

The drug Panangin enhances the negative dromo- and batmotropic effect of antiarrhythmic drugs.

Magnesium reduces the effect of neomycin, tetracycline and streptomycin.

Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; with simultaneous use with atracuronium, decamethonium, succinyl chloride and suxamethonium, an increase in neuromuscular blockade is possible; calcitriol increases the content of magnesium in the blood plasma, calcium preparations reduce the effect of magnesium preparations.

Pharmacokinetic interaction

Drugs that have an astringent and enveloping effect reduce the absorption of asparaginate in the gastrointestinal tract, so it is necessary to observe a three-hour interval between ingestion of Panangin with the above drugs.

special instructions

Particular attention is required for patients with diseases accompanied by hyperkalemia: regular monitoring of the content of potassium in the blood plasma is necessary.

Each film-coated tablet of Panangin contains 36.2 mg of potassium. This should be considered in patients with impaired renal function or in patients receiving potassium preparations or potassium supplements.

Influence on the ability to drive vehicles and control mechanisms

No research has been done. It is not expected to affect the ability to drive vehicles and engage in activities that require an increased concentration of attention and speed of psychomotor reactions.

Terms of dispensing from pharmacies

The drug is released without a prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years (when packed in vials), 3 years (when packed in blisters). Do not use after the expiry date stated on the packaging.

Is it possible in this case to take Panangin alone? Is it possible to take panangin. We do not have data on the interaction of Panangin with Ginkgo Biloba and peony tincture, however, based on the properties of these drugs, there should not be an interaction between them and Panangin.

As we already know, Panangin is a source of trace elements absolutely necessary for the stable functioning of the heart - Potassium and Magnesium. It is clear that the reaction to taking Panangin, i.e. for the correction of the content of Potassium and Magnesium, will also be individual.

In cases of Panangin's use by patients with a high risk of developing hyperkalemia, it is necessary to regularly monitor electrolyte homeostasis. This information resource was created for doctors, pharmacists and consultants. Question: How long can Panangin be taken?

Tell me, how many panangin tablets per day can I take constantly without risking hyperkalemia and hypermagnesemia? Now I go to the gym and follow a diet. The last two nights there were cramps in the leg. Can Panangin be taken?

How long should I take Panangin?

Answer Panangin can help in this situation, however, in addition to potassium and magnesium, which are part of Panangin, other substances may be required for recovery. Question: I am 74 years old. Chronic heart and kidney failure II stage. Can I take Panangin. Answer Valsartan is able to retain potassium in the body, so combined use with Panangin may be undesirable.

According to the doctor's prescription in each case, it can be either increased or decreased. I am 22 years old, the second day the difference between the upper and lower pressure does not exceed 20, for example today 110 to 95, will Panangin help me?

Question Please tell me if it is possible to take Panangin and Novopassit and with what time interval? I have been taking panangin for a year, every morning, 2 tablets. Does it make sense for me to continue the further use of Panangin?

How to drink panangin

My mother is 70 years old, periodically complains of minor pain, heaviness in the heart, increased pressure, how to take panangin in this case? Q: How many hours does Panangin begin to act? The response effect of panangin develops gradually and manifests itself when taken in courses. Answer Transferred by MI is a direct indication for taking Panangin.

You can choose your own, the most suitable Panangin regimen for you. Given these features, you can fairly accurately assess your needs for Panangin and decide whether it is better to take it constantly or in courses. The doctor prescribed Panangin to her. Answer During intensive training, there is a significant loss of potassium and magnesium, therefore, doctors and trainers in these cases, practitioners always recommend taking Panangin.

One of the few combined preparations containing Potassium and Magnesium in an active, easily accessible form for assimilation is Panangin from Gedeon Richter. Drink panangin with a laboratory-confirmed deficiency of potassium and / or magnesium, as well as to prevent their deficiency, which can be triggered by taking diuretics. As part of a complex treatment, take panangin for the treatment of cardiovascular diseases.

In spring, the body experiences a deficiency of vitamins and microelements, and in the fall it prepares for the onset of this deficiency. The lack of Potassium and Magnesium in the body and in the heart muscle does not always manifest itself in the early stages.

Answer Panangin can be combined with Novopassit, both in tablets and in the form of syrup. Answer The usual daily dose of Panangin is indicated in the instructions for use of the drug.