Reduksin is there in pharmacies. Difference of Reduksin from Reduksin light. Use in elderly patients

Reduxin (Sibutramine + Microcrystalline Cellulose) is a drug for getting rid of excess body fat, realizing its therapeutic potential due to the combined action of its constituent components. Sibutramine Goes True medicine only after metabolic transformations in the biological environment of the body. Active metabolites of the drug - primary and secondary amines - inhibit the reuptake of neurotransmitters serotonin and norepinephrine. Increasing the concentration of the latter in synapses nerve endings activates serotonin 5-hydroxytryptamine receptors and adrenoreceptors, which, in turn, contributes to the development of a feeling of satiety, a decrease in the psychological need for food, and an increase in heat production. By stimulating beta-3-adrenergic receptors, sibutramine acts on adipose tissue (the so-called "brown fat"). A decrease in the proportion of adipose tissue in the body composition is accompanied by an increase in the level of lipoproteins high density(so-called " good cholesterol"") in the blood with a simultaneous decrease in the concentration of triglycerides, low density lipoproteins (" bad cholesterol»), total cholesterol and uric acid.

Being a pronounced enterosorbent, microcrystalline cellulose has good absorption capacity and detoxification properties. Absorbs and provides elimination from the body of various pathogens, exogenous and endogenous toxins, allergens, as well as potentially toxic metabolites.

After oral intake Reduxin is quickly and in a significant (about 80%) volume absorbed in the digestive tract.

It undergoes the effect of the first passage through the liver (it is at this stage that the active metabolites of the drug are formed). The half-life of sibutramine is about 1 hour, its active metabolites are 14-16 hours. The drug is excreted mainly by the kidneys. Multiplicity of reception of Reduksin - 1 time per day. The dose in each case is determined by the doctor, observing individual reaction the patient's body initial phase therapeutic course. As such a trial dose, 10 mg is used, with noted adverse reactions the dose for the drug is halved, with confirmed individual intolerance - canceled. Optimal time reception - in the morning, after waking up, but if necessary, Reduxin can be taken with food at a later time. If in the first month drug therapy body weight decreased by less than 5%, then the dose is increased by 1.5 times (up to 15 mg). The duration of the therapeutic course in the absence positive results must not exceed 90 days. If, according to its results, a decrease in body weight by more than 5% was not achieved, the treatment is considered unsuccessful. The same conclusion follows in the event that the patient, after the initial weight loss, begins to gain weight again (3 or more kg). Total duration taking Reduxin should not exceed two years, since this drug is relatively young, and to date, not enough information has been received about its effectiveness and safety. When taking Reduxin, you must adhere to balanced diet and spend enough time exercising.

Pharmacology

Combined drug for the treatment of obesity, the action of which is due to its constituent components. Sibutramine is a prodrug and exerts its effect in vivo through metabolites (primary and secondary amines) that inhibit the reuptake of monoamines (mainly serotonin and norepinephrine). An increase in the content of neurotransmitters in the synapses increases the activity of central serotonin 5-HT receptors and adrenoreceptors, which contributes to an increase in satiety and a decrease in the need for food, as well as an increase in thermal production. Indirectly activating β 3 -adrenergic receptors, sibutramine affects brown adipose tissue. Weight loss is accompanied by an increase in serum concentration blood HDL and a decrease in the amount of triglycerides, total cholesterol, LDL, uric acid.

Sibutramine and its metabolites do not affect the release of monoamines, do not inhibit MAO; have no affinity for a large number neurotransmitter receptors, including serotonin (5-HT 1, 5-HT 1A, 5-HT 1B, 5-HT 2A, 5-HT 2C), adrenoreceptors (β 1, β 2, β 3, α 1, α 2), dopamine (D 1 , D 2), muscarinic, histamine (H 1), benzodiazepine and NMDA receptors.

Microcrystalline cellulose is an enterosorbent, has sorption properties and a nonspecific detoxification effect. It binds and removes from the body various microorganisms, their metabolic products, toxins of exogenous and endogenous nature, allergens, xenobiotics, as well as an excess of some metabolic products and metabolites responsible for the development of endogenous toxicosis.

Pharmacokinetics

Absorption, distribution, metabolism

After taking the drug inside, sibutramine is rapidly absorbed from the gastrointestinal tract, not less than 77%. It undergoes a "first pass" effect through the liver and is biotransformed with the participation of cytochrome P450 isoenzyme 3A4 to form two active metabolites (mono- and didesmethylsibutramine). After taking a single dose of 15 mg C max monodesmethylsibutramine is 4 ng / ml (3.2-4.8 ng / ml), didesmethylsibutramine - 6.4 ng / ml (5.6-7.2 ng / ml). C max sibutramine is achieved after 1.2 hours, active metabolites - after 3-4 hours. Taking it simultaneously with food reduces C max of metabolites by 30% and increases the time it takes to reach it by 3 hours without changing AUC. Rapidly distributed into tissues. The binding of sibutramine to plasma proteins is 97%, and mono- and didesmethylsibutramine is 94%. C ss of active metabolites in the blood is achieved within 4 days after the start of treatment and is approximately 2 times higher than the plasma level after taking a single dose.

breeding

T 1/2 sibutramine - 1.1 h, monodesmethylsibutramine - 14 h, didesmethylsibutramine - 16 h. Active metabolites undergo hydroxylation and conjugation to form inactive metabolites, which are excreted mainly by the kidneys.

Release form

Capsules №2 blue color; the contents of the capsules are white or white with a slightly yellowish tint powder.

Excipients: calcium stearate.

The composition of the capsule shell: titanium dioxide dye, azorubine dye, patent blue dye, gelatin.

10 pieces. - blister packs (aluminum/PVC) (3) - cardboard packs.
10 pieces. - cellular contour packings (aluminum/PVC) (6) - packs of cardboard.

Dosage

Reduksin ® is prescribed orally 1 time / day. The dose is set individually, depending on tolerability and clinical efficacy. The recommended starting dose is 10 mg, with poor tolerance can be taken at a dose of 5 mg. Capsules should be taken in the morning without chewing and drinking enough liquids. The drug can be taken on an empty stomach or combined with food intake.

If a weight loss of 5% or more is not achieved within 4 weeks from the start of treatment, then the dose is increased to 15 mg / day. The duration of therapy with Reduxin should not exceed 3 months in patients who do not respond well enough to therapy (i.e., who fail to reduce weight by 5% of the initial body weight within 3 months of treatment). Treatment should not be continued if, with further therapy (after achieved weight loss), the patient again gains 3 kg or more in body weight.

The total duration of therapy should not exceed 2 years, since there are no data on efficacy and safety for a longer period of taking sibutramine.

Therapy with Reduxin should be carried out by a doctor with practical experience in the treatment of obesity. The drug should be combined with diet and exercise.

Overdose

There are extremely limited data on overdose of sibutramine. In case of overdose, the patient should consult a doctor.

Symptoms: may increase the severity of side effects. Specific features overdoses are unknown.

Treatment: reception activated carbon, gastric lavage, symptomatic therapy, with an increase in blood pressure and tachycardia - the appointment of beta-blockers. any special treatment and there are no specific antidotes. Needs to be done general activities: ensure free breathing, monitor the condition of cardio-vascular system, as well as, if necessary, to carry out maintenance symptomatic therapy. The effectiveness of forced diuresis or hemodialysis has not been established.

Interaction

Inhibitors of microsomal oxidation, incl. inhibitors of cytochrome P450 isoenzyme 3A4 (including ketoconazole, erythromycin, cyclosporine) increase plasma concentrations of sibutramine metabolites with an increase in heart rate and a clinically insignificant increase in the QT interval. Rifampicin, macrolide antibiotics, phenytoin, carbamazepine, phenobarbital and dexamethasone can accelerate the metabolism of sibutramine. The simultaneous use of several drugs that increase the content of serotonin in the blood can lead to the development of a serious interaction. The so-called serotonin syndrome can develop in rare cases with the simultaneous use of Reduxin with selective inhibitors serotonin reuptake drugs (drugs used to treat depression), some migraine drugs (sumatriptan, dihydroergotamine), strong analgesics (pentazocine, pethidine, fentanyl) or antitussives (dextromethorphan). Sibutramine does not affect the effect of oral contraceptives.

With the simultaneous administration of sibutramine and ethanol, there was no increase in the negative effect of ethanol. However, the use of alcohol is absolutely not combined with the dietary measures recommended when taking sibutramine.

Side effects

Side effects, depending on the impact on organs and organ systems, are presented in the following order (often -> 10%, sometimes - 1-10%, rarely -< 1%).

From the CNS and peripheral nervous system: often - dry mouth, insomnia; sometimes - headache, dizziness, anxiety, paresthesia, and changes in taste; in isolated cases - back pain, depression, drowsiness, emotional lability, anxiety, irritability, nervousness, convulsions.

One patient with schizoaffective disorder thought to have existed prior to treatment developed acute psychosis after treatment.

Since the cardiovascular system: sometimes - tachycardia, palpitations, increased blood pressure, vasodilation. There is a moderate rise in blood pressure at rest by 1-3 mm Hg. and a moderate increase in heart rate of 3-7 beats per minute. In some cases, more pronounced increases in blood pressure and heart rate are not excluded. Clinically significant changes blood pressure and pulse levels are recorded mainly at the beginning of treatment (in the first 4-8 weeks).

From the side digestive system: often - loss of appetite, constipation; sometimes - nausea, exacerbation of hemorrhoids. With a tendency to constipation in the early days, it is necessary to control the evacuation function of the intestine. If constipation occurs, stop taking and take a laxative. In isolated cases, abdominal pain, a paradoxical increase in appetite, a transient increase in liver enzymes.

Dermatological reactions: sometimes - sweating; in isolated cases - pruritus, Shenlein-Genoch purpura (hemorrhages in the skin).

On the part of the body as a whole: in isolated cases, the following clinically significant adverse events are described: dysmenorrhea, edema, flu-like syndrome, thirst, rhinitis, acute interstitial nephritis, bleeding, thrombocytopenia.

Withdrawal reactions such as headache or increased appetite are rarely observed. There is no evidence that after treatment there is withdrawal syndrome, withdrawal syndrome, or mood disturbances.

Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency weaken over time. Side effects are generally mild and reversible.

Indications

For weight loss with following states:

• alimentary obesity with a body mass index (BMI) of 30 kg/m2 or more;
• alimentary obesity with a BMI of 27 kg / m 2 or more in combination with other risk factors due to overweight body (diabetes mellitus type 2 / non-insulin dependent / or dyslipoproteinemia).

Contraindications

• Availability organic causes obesity (eg, hypothyroidism);
• serious violations eating behavior (anorexia nervosa or bulimia nervosa);
• mental illness;
• Gilles de la Tourette syndrome (generalized tics);
• simultaneous reception MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or their use within 2 weeks before the appointment of the drug Reduxin ® ; the use of other drugs acting on the central nervous system (for example, antidepressants, antipsychotics); drugs prescribed for sleep disorders containing tryptophan, as well as other drugs central action to reduce body weight;
• ischemic heart disease, decompensated chronic heart failure, birth defects heart disease, peripheral arterial occlusive disease, tachycardia, arrhythmias, cerebrovascular disease (stroke, transient disorders cerebral circulation);
• uncontrolled arterial hypertension(BP above 145/90 mm Hg);
• thyrotoxicosis;
• severe violations liver function;
• severe renal dysfunction;
• benign hyperplasia prostate;
• pheochromocytoma;
• angle-closure glaucoma;
• established medicinal, narcotic or alcohol addiction;
• pregnancy;
• lactation (breastfeeding);
• children and adolescents up to 18 years of age;
• old age over 65;
• established hypersensitivity to sibutramine or to other components of the drug.

With caution, the drug should be prescribed under the following conditions: arrhythmias in history, chronic insufficiency circulation, disease coronary arteries(including history), cholelithiasis, arterial hypertension (controlled and history), neurological disorders, including mental retardation and convulsions (including history), abnormal liver function and / or kidney light and medium degree severity, motor and verbal tics in history.

Application features

Use during pregnancy and lactation

The drug should not be used during pregnancy due to the lack of a sufficiently convincing number of studies on the safety of the effects of sibutramine on the fetus.

Women childbearing age while taking Reduxin, contraceptives should be used.

Reduxin ® should not be used during breastfeeding.

Application for violations of liver function

Application for violations of kidney function

Use in children

Contraindicated in children and adolescence up to 18 years old.

special instructions

Reduxin ® should be used only in cases where all non-drug measures to reduce body weight are ineffective - if the weight loss within 3 months was less than 5 kg.

Treatment with Reduxin should be carried out within the framework of complex therapy for weight loss under the supervision of a physician with practical experience in the treatment of obesity.

Complex therapy for obesity includes both changes in diet and lifestyle, and an increase in physical activity. An important component therapy is to create the prerequisites for a persistent change in dietary habits and lifestyle, which are necessary to maintain the achieved weight loss even after drug therapy is discontinued. Patients need to change their lifestyle and habits as part of therapy with Reduxin ® in such a way that, after completion of treatment, the achieved weight loss is maintained. Patients should clearly understand that failure to comply with these requirements will lead to a repeated increase in body weight and repeated visits to the attending physician.

In patients taking Reduxin ® , it is necessary to measure blood pressure and heart rate. In the first 2 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. In patients with arterial hypertension (in whom, against the background of antihypertensive therapy blood pressure above 145/90 mm Hg), this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg during repeated measurement. treatment with Reduxin ® should be suspended.

Particular attention should be paid to the simultaneous administration of drugs that increase the QT interval. These drugs include blockers of histamine H 1 receptors (astemizole, terfenadine); antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol); Gastrointestinal motility stimulants (cisapride, pimozide, sertindole and tricyclic antidepressants). Caution should be observed when using the drug against the background of conditions that are risk factors for an increase in the QT interval (hypokalemia, hypomagnesemia).

The interval between taking MAO inhibitors and Reduxin should be at least 2 weeks.

The relationship between taking Reduksin and the development of primary pulmonary hypertension not established, however, given the well-known risk of drugs in this group, with regular medical monitoring, it is necessary Special attention address symptoms such as progressive dyspnea (breathing disorder), pain in chest and swelling in the legs.

Influence on the ability to drive vehicles and control mechanisms

Taking the drug Reduxin ® may limit the patient's ability to drive vehicles and control mechanisms.

Among legal pharmaceutical preparations, analogues of Reduxin are preparations of sibutramine hydrochloride monohydrate. The main difference between generics and the original is the absence or presence of MCC among the fiber components and the type of substance used to make the gel capsules directly. The dosage of sibutramine in such preparations is 10 or 25 mg.

Conditional analogues include various options for dietary supplements offered by the Chinese market. Officially, they do not recognize the presence of sibutramine in them, proving that all their effectiveness is the action of the herbs and plants that make up the composition. At the same time, many cases of the opposite are known, when sibutramine and the complete absence of a plant component were detected in Chinese preparations.

Analogues of Reduxin sold in pharmacies

Lindax is a Czech drug manufactured by Zentiva. Previously available in pharmacies, it has now been discontinued due to the fact that many European countries have abandoned the use of sibutramine in the treatment of obesity. The drug was produced in capsules at a dosage of 10 and 15 mg. Today it is rarely found for sale, mainly distributed through forums and illegal sale.

Meridia is the original sibutramine anti-obesity drug. In the early 2000s, it was offered as a panacea, since it was able not only to discourage appetite by acting on the central nervous system and hunger center, but also to cause thermogenesis, which allowed burning up to 100 additional kcal / day. Sold in dosages of 10 and 15 mg.

Reduxin-Met - the drug is ironically called the "bikinist's dream", but in fact it is used to treat diabetes in obese people. In healthy people, these pills can discourage appetite and cause a violation of insulin metabolism. Due to the presence of metformin in the composition of the drug, the state of health in diabetes mellitus is corrected, however, with an unsuccessful combination of taking pills, training and a low-carbohydrate diet, real hypoglycemia can occur. Serious athletes do not take the drug, usually it is purchased by lovers of the first year of training, who have not yet realized how to build a diet so that it does not cause hunger.

Slimia is a drug from the Indian company Torrent Pharmaceuticals. Officially, it has never been sold in Russia, it is distributed illegally through forums and social networks. It does not have a fundamental difference from Reduksin. Its sale is prohibited solely due to legal disagreements - the instructions for the drug do not have a translation into Russian.

Redews is another Indian drug that has become widespread due to active campaigning in foreign forums. It is sold illegally, but due to the low price, no one is in a hurry to make sales legal.

Analogues sold without a prescription

In Russia, the drug is not considered something serious, but refers to harmless helpers in losing weight. Sales can be seen on specialized sites and forums where private individuals are involved in its distribution.

Officially, the drug is among the potent and should be sold only by prescription.

Analogues of Reduksin among dietary supplements

In reality, such drugs do not exist. Periodically, anorexigenic properties are tried to be attributed to the herbal supplement 5-HTP, as well as to various forms of fiber, hoodie cactus extracts, and other substances. In fact, they show individual effectiveness, which does not work for many people, and in some even causes side effects.

This fact does not prevent manufacturers from manipulating the minds of consumers. This is how dietary supplements appear, which copy the name of the sibutramine drug and contain the prefix "Light".

Be that as it may, the decision to take sibutramine should be made by a dietitian. And not just a doctor whom you found for the sake of issuing a prescription, but one who worked on compiling an individual diet and explained in detail to you how to eat and what, so as not to feel hungry, not to take packs of pills and get rid of excess weight.

preparation of the article - Serezhkina Tatiana, nutritionist

? "has always been considered relevant, and the ideal means to achieve this goal has not yet been invented, then interest in the drug arose long before its release, from the moment when the first information about it appeared.

Release form

Compound

Indications

Contraindications

Prescribing with Caution

Side effects

The danger of sibutramine: in some patients with mental lability, regardless of the presence of cardiovascular diseases, a long ( for more than two years) taking the drug can lead to suicidal tendencies.

Dosage

The total duration of treatment should not exceed two years.

Features of the drug

• The action of the drug leads to a decrease in salivation, and this harms the teeth, which eventually form caries.
• The drug can provoke the appearance of candidiasis, and some periodontal diseases.
• Against the background of taking a means for losing weight, you need to reduce alcohol consumption to a minimum.
• When working, which requires increased concentration of attention, for example, when driving a vehicle, it is undesirable to take the drug.
• You can take Reduxin only after consulting a doctor. As a rule, doctors prescribe it in cases where other measures to reduce body weight do not justify themselves. You can not take the drug and at the same time do not adjust the eating behavior - this will only worsen the situation. Together with nutritionists, you need to choose a diet, develop a set of suitable physical activities, and change eating habits. This drug makes sense to take only as part of complex therapy.

Reduxin Light

Release form and content

What will help you lose weight?

Most nutritionists respond positively to the use of the Reduxin Light supplement. Thanks to linoleic acid, which is in a conjugated state, the body physiologically correctly distributes energy and nutrients. Favorable energy conditions are created, and the work of the whole organism is normalized due to the correct release of body fat.

Application

Even at the initial stage of the course, results will already appear in the form of a decrease in body fat and a simultaneous increase in muscle mass. The formation of a sports silhouette occurs precisely due to the combustion of fat in the muscles.

Pharmacokinetics

The use of the drug prevents the secondary deposition of subcutaneous fat, and helps to avoid a rebound effect. This is due to the linoleic acid it contains. Natural linoleic acid is found in meat and milk, in vegetable oils. Industrial extraction of this substance is carried out from safflower oil. Conjugated linoleic acid, entering the body, activates fermentation, due to which fat is processed, and also blocks the process of new accumulation of subcutaneous fat. There is an improvement in metabolism, which, in fact, is nothing more than the ability of the body to burn the calories received, extracting from this the energy necessary to maintain life. Acceleration of calorie burning leads to the fact that spare fat deposits cease to be unnecessary organic ballast and are gradually drawn into the metabolic process.

The additional energy received is used by the body to strengthen muscle tissue and to synthesize proteins.

Indications

• Weight loss in obesity and related diseases cardiovascular, endocrine, digestive).

Contraindications

• Children under 18 years old.
• Pregnant women.
• Lactating women.

Dosage

The optimal dose of linoleic acid to obtain maximum efficiency from Reduxin Light is 2.5 g per day - this corresponds to 4-6 capsules of the drug per day.

Side effects

Price

Analogues

Reduxin is a drug for the treatment of obesity. Due to its high price, many have to look for analogues in pharmacies in order to reduce costs.

Reduksin - description and indications

The drug Reduxin belongs to the group of drugs for weight loss with a central mechanism of action. It is produced in the form of tablets, produced in Russia by the Ozone company. The composition includes 15 mg of sibutramine, 153.5 mg of microcrystalline cellulose. The cost of 30 capsules is 1700 rubles.

In composition and group, the drug Reduxin Met differs from Reduxin.

In Reduxin Met, which belongs to the biguanide hypoglycemic drugs, in addition to sibutramine, cellulose is added. This is a unique medicine, the packaging of which contains tablets and capsules with different components (metformin is separated into a separate form). A box of such a drug 30 + 60 tablets costs 2800 rubles.

Under the Reduxin brand, another product from the dietary supplement group is also produced - Reduxin Light Reinforced formula, designed for losing weight. The difference between the means is cardinal, because Reduxin Light has the following composition:

The pharmacological action of Reduxin is due to the presence of sibutramine. This substance increases the content of special elements in the body, due to which the activity of serotonin, adrenergic receptors increases. This causes a decrease in appetite, the appearance of a feeling of satiety. Also, the substance affects adipose tissue, provokes a decrease in cholesterol, triglycerides, uric acid.

Metformin in Reduxin Met reduces the effects of hyperglycemia, while not stimulating insulin production. The substance also helps to normalize fat metabolism, reduce blood cholesterol. Indications for taking drugs are the same:

The drug Reduxin Light has the same indications, and also serves as an additional source of linoleic acid.

Contraindications, negative effects

Before starting treatment, it is better to clarify in advance the contraindications and side effects of Reduxin. You can not take the drug for allergies, intolerance to the components. There will be no effect from the reception, and harm is also possible with serious causes of obesity:

Among the list of contraindications is anorexia, bulimia - with such disorders, the medicine can only do harm, causing even greater appetite disorders. Other treatment restrictions include:

The tool can be harmful in case of heart pathologies - coronary artery disease, insufficiency of function, arrhythmias. You can not drink it with a stroke.

Side effects usually develop at the very beginning of therapy, in the first month, and then disappear or weaken. Most often these include dry mouth, headaches and dizziness. Many people have a change in taste, paresthesias are observed. The heart often reacts with tachycardia, increased pressure, and increased heart rate. Nausea, constipation, itching of the skin, changes in blood composition may also appear.

Instructions for use

Reduxin is enough to drink once / day, but the dose is set individually. To clarify tolerance, you should first drink the minimum dosage with a gradual increase. Treatment with Reduxin is carried out in the morning, without chewing, drink a tablet with a full glass of water.

In parallel, you can eat or take the drug on an empty stomach - the effectiveness will not change.

The initial dose is 10 mg, if side effects immediately occur, the dose is reduced to 5 mg.

With Reduxin therapy for a month, body weight regression should be at least 5%. Otherwise, add a dose of up to 15 mg or more. The course lasts 3 months, after which you can take a break. You can continue taking only with a stable positive response to therapy. The maximum duration of taking Reduxin is 2 years.

Reduxin Met is taken in this way:

After 2-3 weeks, you can increase the dosage of metformin to 2 tablets, the maximum dose is 2550 mg / day. The total duration of therapy is 1 year, no more. Reduxin Light drink 2 capsules / day to control weight, 6 capsules - for serious weight loss. Treatment is carried out with meals, the course is 2 months.

Drug analogues

There are a number of analogues of the drug without a prescription, and only some of them are cheaper. Sibutramine-based products are quite expensive due to the complexity of production. There are also a number of drugs with a similar effect, differing in composition. Here is a list of popular tools:

It is possible to replace Reduxin with a drug with a different active substance only after the approval of the new course by the attending physician.

goldline plus

Goldline is not a cheaper drug, but it is prescribed no less often, since Reduxin is often not available in pharmacies. It is a complete structural analogue of Reduxin, contains sibutramine (15 mg), cellulose (153.5 mg). Producer - Izvarino LLC.

Combined remedy, Goldline helps to achieve faster satiety and reduce the need for food.

Cellulose enhances the effect of the treatment. It serves as a sorbent, binding toxins, decay products, and is considered a good detoxifying component. It is cellulose that helps to remove metabolites that are responsible for the development of endogenous toxicosis.

Slimia

This is another remedy based on sibutramine (10-15 mg) and cellulose (95.5 mg). As can be seen, there is a reduced amount of sorbent in comparison with Reduxin. The drug is available in the form of gelatin capsules. Its price is 1400 rubles. Like analogues, Slimia is widely recommended for the treatment of obesity, not provoked by organic causes. As an element of complex therapy, Slimia is indicated for such conditions:

It is forbidden to be treated with Slimia for anorexia, bulimia, mental disorders ah, systemic tics, taking drugs that act on the central nervous system, with serious pathologies of the heart. Additionally, in contraindications, the manufacturer indicates prostate adenoma, glaucoma, adrenal tumors. Dose per day - 5-15 mg. In case of an overdose, respiratory and cardiac disorders may occur.

Xenical

This medicine is also used as a remedy for obesity, but has a different active substance and works in a different way. It contains orlistat, an inhibitor of lipases in the gastrointestinal tract. The price of the medicine is 850 rubles / 21 capsules. Xenical works for a long time, being localized in the stomach, small intestine. It prevents specific enzymes from breaking down fats into fatty acids, monoglycerides. Unsplit fats cannot be absorbed, as a result, food loses calories, body weight decreases.

Weight loss is observed after 2 weeks from the start of treatment. Side effects usually occur at the beginning of therapy and relate to the gastrointestinal tract - diarrhea develops, oily discharge from the rectum, gases, frequent urge to defecate. There may be pain in the abdomen. Later, such phenomena pass. Indications of the drug:

Xenical is contraindicated in cholestasis, malabsorption syndrome. It should also not be taken by pregnant or lactating women.