Why is it prescribed and how to take Octolipen? Influence on the ability to drive vehicles and mechanisms. Terms and conditions of storage

"Octolipen" is a drug with an antioxidant effect that regulates lipid and carbohydrate metabolism.

The drug is produced in three forms release: tablets, capsules and ampoules with a concentrate.

The main active ingredient of "Octolipen" is thioctic acid. Consider the composition of each dosage form.

Capsules

Capsules contain 300 mg of the active ingredient.

As auxiliary components used:

Gelatin.
Silicon dioxide colloidal.
Quinoline yellow.
Dye "sunset".
Starch.
calcium hydrophosphate.
Magnesium stearate.

The dosage form is a yellow hard capsule. "Octolipen" in this form is available in a blister pack of 10 pieces per blister. secondary packaging may contain 30 and 60 capsules.

Tablets

One tablet contains 600 mg of the active ingredient.

Giproloza.
Hyprolose is low-substituted.
Silicon dioxide is colloidal.
Croscarmellose sodium.
Macrogol 6000.
Talc.
titanium dioxide.
Iron oxide yellow.
Aluminum lacquer based on quinoline yellow.

The dosage form is a pale yellow biconvex tablet. On one side of the tablet is applied risk. The drug is available in a blister pack of 30, 60 and 100 tablets.

Concentrate for droppers

The composition of one ampoule includes 30 mg of the active active substance (the calculation is per 1 ml).

As additional components used:

Denatria edetat.
Ethylenediamine.
Water for injections.

The concentrate for the preparation of a solution for infusion has a greenish-yellow color and is available in 10 ml dark glass ampoules. Secondary packaging contains 10 and 20 ampoules.

Pharmacological properties of the drug "Octolipen", pharmacokinetics

Thioctic acid is formed during the oxidative decarboxylation of keto acids and is an endogenous antioxidant in its structure. Its main functions include the binding of free radicals, the restoration of the intracellular level of glutathione. In addition, it improves neuronal trophism and conductivity. nerve cells. Thioctic acid, being a coenzyme, is involved in the oxidative decarboxylation of pyruvic acid.

As a result of the influence of the drug, there is an increase in the level of glycogen in the liver and a decrease in blood glucose, as well as overcoming insulin resistance. Character biochemical action thioctic acid is similar to that of B vitamins. The substance normalizes lipid and carbohydrate metabolism, activates cholesterol metabolism; showing lipotropic effect, improves liver activity; demonstrates a detoxifying effect in case of intoxication, including poisoning with salts of heavy metals.

When taken orally, "Octolipen" is rapidly absorbed into gastrointestinal tract. Simultaneous reception the drug with food slows down its absorption, so it must be taken separately. The bioavailability of the drug is 30-60%. The maximum plasma concentration is reached 25-40 minutes after a single dose.
Thioctic acid is metabolized in the liver. It is excreted mainly by the kidneys in the amount of 80-90% of the initial dose.

The main indications for taking "Octolipen"

The main indications of the drug "Octolipen" include:

Polyneuropathy of various origins (diabetic, alcoholic).
Liver dystrophy (including fatty degeneration).
Hepatitis in a chronic form.
Alcohol poisoning.
Elevated cholesterol.
Cirrhosis of the liver with metastases.
Hepatitis A at any stage.
Poisoning by poisonous species of mushrooms.

The method of taking the drug "Octolipen", dosing regimen

Thioctic acid in oral forms of release (tablets, capsules) should be taken orally on an empty stomach, before meals. Neither tablets nor capsules should be chewed, divided or opened. "Octolipen" is taken orally as a whole and washed down large quantity water.
The recommended dose for an adult is 600 mg per day. This amount is equivalent to one tablet or two capsules.
Oral forms of release are not recommended for more than 3 months, but if necessary, the course of treatment can be extended.
As for the concentrate for infusion, it must be diluted before use. isotonic saline sodium chloride (from 50 to 250 ml). The prepared solution is injected intravenously once a day. The average daily dose should not exceed 600 mg. The course of treatment is from 2 to 4 weeks.
It should be noted that "Octolipen" in ampoules is very sensitive to light, so it is necessary to protect the drug from direct sunlight. For these purposes, it is better to use foil or dark bags. Ready solution stored no more than 6 hours from the moment of preparation.

Contraindications of the drug "Octolipen"

The drug "Octolipen" is often prescribed by doctors and has a relatively small list of contraindications. These include:

Children under 18 years of age (due to lack of clinical data).
Individual intolerance to the components of the drug.
Pregnancy.
breastfeeding period.

Side effects of the drug "Octolipen"

Despite the popularity of the drug among doctors, it is necessary to take into account side effects which are not very rare. These include:

Dyspeptic disorders (diarrhea, nausea, vomiting, abdominal pain). Characteristic for oral forms of release.
Decreased blood glucose levels, hypoglycemia.
Increased sweating.
Dizziness.
Frequent headaches.
Violation of vision.
Allergic reactions: urticaria, itching, skin rash, anaphylactic shock.
Point hemorrhages in the mucous membranes.
Hemorrhagic rash, convulsions. Typical for intravenous administration.
Thrombophlebitis.
thrombocytopenia.
Violation of taste sensations.
Labored breathing
Raise intracranial pressure.

Cases of drug overdose have been recorded. In this case, vomiting, nausea, headache, lowering sugar levels. If you suspect severe overdose the drug requires emergency hospitalization and standard measures, including gastric lavage, intake of enterosorbents.

special instructions

Patients with diabetes during treatment with Octolipen should monitor their blood glucose levels. In some cases, to prevent the development of hypoglycemia, it may be necessary to reduce the dose of insulin or oral antidiabetic agent.
During the period of therapy, it is required to stop taking alcoholic beverages to avoid weakening the therapeutic effect of thioctic acid.
When using oral forms of "Octolipen" it is recommended to refrain from the use of dairy products because of the calcium which is their part.
Between doses, an interval of at least 2 hours should be observed.

drug interaction

Simultaneous administration of thioctic acid and cisplatin reduces the effectiveness of the latter.
Insulin in complex therapy enhances the action of thioctic acid. Dose adjustment is necessary in insulin dependent patients.
Solution for infusion "Octolipen" is incompatible with solutions of levulose, glucose, Ringer's solution.
Simultaneous intake of thioctic acid with ethanol weakens the effect of the former.
"Octolipen" interacts with preparations containing salts of calcium, magnesium and iron, forming complex compounds.

Analogues of the drug "Octolipen"

Octolipen has several structural analogues, which completely coincide in composition and pharmacological group. These include:

Berlition.
"Thiogamma".

It is worth remembering that "Octolipen" and its analogues are prescription drugs and should be prescribed only by the attending physician, to avoid complications and side effects.

(α -lipoic acid).

Auxiliary components in capsules and tablets: calcium hydrogen phosphate dihydrate , magnesium stearate , silicon dioxide colloidal , medical gelatin , quinoline yellow E 104 , titanium dioxide E 171 , dye sunset yellow E 110 .

Auxiliary components in the concentrate for solution for infusion: ethylenediamine , water for injection, disodium edetate.

Release form

Octolipen is produced in capsules and tablets coated with film casings. Another form of release is a concentrate for preparing a solution for infusion.

pharmachologic effect

Neuroprotective, hypoglycemic, hypocholesterolemic, hepatoprotective and hypolipidemic agent.

Pharmacodynamics and pharmacokinetics

Main active substance drug is endogenous .

Thioctic acid reduces the level of glucose concentration in the blood, helps to overcome, and also increases the glycogen content in the liver. It is close in nature of action to vitamins of group B. It takes part in lipid and carbohydrate metabolism, improves liver function, activates metabolism.

In addition, thioctic acid acts as hepatoprotective , hypocholesterolemic , hypolipidemic and hypoglycemic means. It improves trophism neurons , reduces the manifestation of alcohol and diabetic polyneuropathy , activates axonal conduction .

The concentrate for the preparation of a solution for internal administration reaches a maximum concentration of 25-38 μg / ml. The volume of distribution is approximately 450 ml/kg.

Capsules and tablets, when taken orally, are absorbed for a short time. If consumed with meals, absorption is reduced. Bioavailability is 30-60%. The maximum concentration in the blood is reached in 25-60 minutes.

Regardless of the dosage form, the drug is processed in the liver through conjugation and oxidation of the side chain. It is excreted through the kidneys by about 80-90%. The half-life is 20-50 minutes.

Indications for use Octolipen

Indications for use of Octolipen in the form of capsules of 300 and 600 mg:

diabetic polyneuropathy ;
alcoholic polyneuropathy .

Indications for the use of Octolipen in the form of a solution for infusions of 12 and 25 mg:

fatty dystrophy liver;
chronic hepatitis ;
hyperlipidemia ;
toadstool poisoning.

Contraindications

Contraindications to the use of the drug are as follows:

hypersensitivity to the components of the drug;
period lactation ;
childhood.

Side effects

When using this drug, the following side effects may occur:

appearance (even anaphylactic shock is possible);
from the side digestive tract possible nausea , vomit ;
symptoms hypoglycemia .

Octolipen - instructions for use

For those who have been prescribed Octolipen capsules or tablets, the instructions for use provide for taking in the morning on an empty stomach half an hour before meals daily dose. The simultaneous use of food reduces the effectiveness of the drug. Chewing and crushing tablets and capsules is also not recommended.

The daily dose, which provides instructions for the use of Octolipen - 600 mg (1 tablet or 2 capsules). However, the duration of the course and the final dosage is determined by the doctor.

To increase the effectiveness of the drug, in some cases, the first 2-4 weeks are prescribed the use of a concentrate for the preparation of infusions, after which capsules or tablets are used in standard doses.

To prepare the solution, 1-2 ampoules are used, which are diluted in 50-250 ml of 0.9% sodium chloride solution. After preparation, it is administered intravenously. The standard dose is 300-600 mg per day.

The drug is sensitive to light, so the ampoules should be taken out only immediately before use. At this time, it is also desirable to protect the vial from sunlight. The prepared solution should be stored in a place well protected from light and no longer than 6 hours after preparation.

Overdose

Due to an overdose of the drug, it may occur, vomit and nausea . Treatment is symptomatic.

Interaction

The drug stimulates hypoglycemic effect insulin and antidiabetic drugs that are taken orally. That is why when combining these drugs, you need to constantly monitor the content of glucose in the blood plasma and adjust the dosage of antidiabetic drugs if necessary.

Octolipen is a drug that improves the condition nervous tissue. Its main active ingredient is a-lipoic acid (thioctic). Normally, this compound is produced in the human body itself, maintaining its health (similar to B vitamins).

Treatment with Octolipen is primarily aimed at normalizing the nutrition and functions of the nervous tissue in polyneuropathies (impaired functioning peripheral nerves expressed in violation of sensitivity).

In this article, we will consider why doctors prescribe Octolipen, including instructions for use, analogues and prices for this drug in pharmacies. REAL REVIEWS people who have already used Octolipen can be read in the comments.

Composition and form of release

Clinical and pharmacological group: a drug with an antioxidant effect that regulates carbohydrate and lipid metabolism.

In free sale you can find the drug "Octolipen". Capsules are the most preferred form. Each of them contains 300 mg of lipoic acid. It is enclosed in a convenient gelatin shell that does not need to be damaged, just drink the capsule with water.

The second option is “Octolipen” tablets. Active substance the same - lipoic acid in the amount of 600 mg. That is, if necessary, increase the dosage, it can be best option. Auxiliary substances are calcium, silicon and starch. They are essential for shaping.

What helps Octolipen?

The drug Octolipen is part of the complex therapy for:

poisoning, including mushrooms, salts heavy metals and etc.;
chronic and acute inflammatory disorders liver functions (cirrhosis, hepatitis);
degenerative and dystrophic changes nervous system of various etymologies, including diabetic and alcoholic polyneuropathy, neuralgia;
critically elevated level cholesterol, triglycerides in the blood, as well as other disorders of lipid and lipoprotein metabolism.

Pharmacological properties

Octolipen has a pronounced protective effect against toxic products formed in the body as a result of oxidation reactions. It does not allow superoxidation and other damaging substances to adversely affect the state of cell membranes.

Thioctic acid is a coenzyme that is involved in the reaction of cleavage of the carboxyl group from keto acids. Lowers blood sugar by storing it as glycogen. Reduces insulin tolerance. Improves metabolism. Renders positive therapeutic effect in the treatment of diffuse peripheral damage to nerve fibers.

These properties make it possible to use Octolipen as a means for normalizing liver function, splitting lipids, reducing blood glucose levels, and preventing vascular atherosclerosis. Thanks to thioctic acid, trophic interactions of neurons and nerve conduction in axonal disorders are normalized. Octolipen smooths out the manifestations of polyneuropathy in diabetics and people with alcohol dependence.

Instructions for use

For those who have been prescribed Octolipen 600 capsules or tablets, the instructions for use provide for taking the daily dose in the morning on an empty stomach half an hour before meals. The simultaneous use of food reduces the effectiveness of the drug. Chewing and crushing tablets and capsules is also not recommended.

The recommended dose is 1 tab. (600 mg) 1 time / day.

It is possible to carry out step therapy: oral administration of the drug begins after a 2-4-week course parenteral administration thioctic acid. The maximum course of taking tablets is 3 months. In some cases, Octolipen therapy involves more long-term use. Duration of admission is determined by the attending physician.

Contraindications

Octolipen is not prescribed to patients with personal intolerance to the active or additional components of tablets and capsules. Octolipen is not used in pediatric practice.

Octolipen should be taken with caution in patients with diabetes mellitus (due to increased action of antidiabetic agents and an increased risk of hypoglycemia).

Side effects

Since the main component of the drug is “natural” for the body, it rarely causes undesirable effects. In very rare cases it can be:

Taste disorders;
Digestive disorders, nausea, heartburn, abdominal pain;
hypoglycemia;
Hives.

Pregnancy and lactation

Octolipen is not recommended for pregnant and lactating women, as this moment there is no exact information about how its use affects the development of the fetus and whether it affects mother's milk.

Analogues

The following drugs have the same effect as Octolipen:

Lipoic acid;
Alpha lipone;
Neurolipon;
Dialipon;
Thiogamma;
Thiogamma Turbo (parenteral solution);
Thioctacid;
Tioktodar;
Thio-Lipon-Novopharm;
Berlition 600;
Espa Lipon.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of OCTOLIPENE tablets in pharmacies (Moscow) is 620 rubles.

Terms of sale

Released in pharmacies strictly by prescription.

Maria
I have been suffering from type 2 diabetes for 13 years. Two years ago, a complication arose - polyneuropathy lower extremities. experienced severe pain, numbness of the legs. Sensitivity was almost completely lost. Even in warm weather, my feet were cold. The doctor prescribed a course of treatment with Octolipen. At the beginning of treatment, sugar dropped, but the endocrinologist changed the dose of insulin, and everything returned to normal. The medicine helped me."
Nonna
I was in neurology with a diagnosis of neuropathy facial nerve. In addition to the main treatment, I received octolipen drips (according to m / s). A cloudy yellow solution was poured into a bottle with a solution of magnesium sulfate from a syringe and dripped rapidly. A minute later I felt heaviness under the sternum and frontal part of the head. After this dropper, I felt heaviness and weakness. The doctor came in quickly and left - smile, close your eyes. By the time I opened my eyes, she was no longer in the room. She was discharged from the hospital and then ended up in pulmonology with atypical pneumonia, sarcoidosis is questionable. The cause cannot be determined, now on hormones. And there is no improvement.
Hope
I drink octolipen 600 mg for 20 days and it seems to me that I have gained weight, but it does not reduce my sugar
Anna
The drug was prescribed to me by a neurologist, I completely did not have the sensitivity of the lower extremities, I took it for almost a year intermittently and in combination with another drug, the result is positive, my legs feel, my cholesterol has decreased, I lost weight, I looked younger, in addition to the drugs, I also changed my diet, do exercises and swim in open water all year round, hoping for a miracle that I took a pill and everything will go away is stupid to hope, the drug is very good, but if it didn’t help you? after the first intake, the feces will be greasy; if not, then the drug may not be of high quality

An antioxidant drug that regulates carbohydrate and lipid metabolism

Active substance

Thioctic (α-lipoic) acid (thioctic acid)

Release form, composition and packaging

Tablets, coated film sheath from light yellow to yellow color, oval, biconvex, with a risk on one side; at a break from light yellow to yellow.

Excipients: low-substituted hyprolose (low-substituted hydroxypropyl cellulose) - 108.88 mg, hyprolose (hydroxypropyl cellulose) - 28.04 mg, croscarmellose (croscarmellose sodium) - 24.03 mg, colloidal silicon dioxide - 20.025 mg, magnesium stearate - 20.025 mg.

Shell composition: Opadry yellow (OPADRY 03F220017 Yellow) - 28 mg (hypromellose (hydroxypropyl methylcellulose) - 15.8 mg, macrogol 6000 (polyethylene glycol 6000) - 4.701 mg, titanium dioxide - 5.27 mg, talc - 2.019 mg, quinoline yellow aluminum varnish (E104) - 0.162 mg , iron dye yellow oxide (E172) - 0.048 mg).

10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (6) - packs of cardboard.
10 pieces. - cellular contour packings (10) - packs of cardboard.

pharmachologic effect

Enhances the action of insulin and oral hypoglycemic agents medicines(Adjustment of their dose is necessary, as well as regular monitoring of blood glucose to avoid hypoglycemia).

Simultaneous administration of the drug Octolipen and preparations of iron, magnesium and calcium is not recommended (due to the formation of a complex with metals). The interval between doses should be at least 2 hours.

Ethanol and its metabolites weaken the therapeutic activity of thioctic acid.

special instructions

During treatment (especially initial stage) requires regular monitoring of blood glucose in patients with diabetes mellitus. In some cases, it may be necessary to reduce the dose of insulin or oral hypoglycemic drug in order to avoid the development of hypoglycemia.

Patients taking Octolipen should refrain from drinking alcohol.

Simultaneous ingestion of food may interfere with the absorption of the drug.

When taking the drug Octolipen, the use of dairy products is not recommended (due to the calcium content in them). The interval between doses should be at least 2 hours.

Influence on the ability to drive vehicles and control mechanisms

Influence on the ability to manage vehicles and mechanisms have not been specifically studied. Necessary
exercise caution when driving and engaging in potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Pregnancy and lactation

The use of the drug during pregnancy is contraindicated due to the lack of sufficient clinical experience the use of thioctic acid in pregnant women. Reproductive toxicity studies did not reveal any risks in relation to fertility, effects on fetal development and any embryotoxic properties of the drug.

The use of the drug Octolipen during lactation is contraindicated due to the lack of data on the penetration of thioctic acid into breast milk.

Application in childhood

The use of the drug in children and adolescents under the age of 18 years is contraindicated (efficacy and safety have not been established).

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 2 years.

Octolipen is a neuroprotective, hepatoprotective, hypoglycemic, hypolipidemic and hypocholesterolemic drug. Medicine pharmacological group vitamin-like substances.

Treatment with Octolipen, first of all, is aimed at normalizing the nutrition and functions of the nervous tissue in case of polyneuropathies (impaired functioning of peripheral nerves, expressed in violation of sensitivity).

The active substance of the drug - thioctic (α-lipoic) acid - is an antioxidant that blocks free radicals, prevents liver disease and the formation of fatty plaques on the walls of blood vessels. With age, the human body produces less and less of it.

A vitamin-like substance - thioctic acid - increases the body's susceptibility to insulin and hypoglycemic tablets, lowers blood sugar levels, and also contributes to the normalization of fat and carbohydrate metabolism.

Octolipen photo

It is characterized by active hepatoprotective action. In case of intoxication, it stimulates the removal of a toxic substance from the body. Improves nutrition and functioning of the cells of the peripheral nervous system.

Release forms

1. Lipoic acid 300 mg capsules.
2. Coated tablets 600 mg lipoic acid.
3. Concentrate for solution for infusion (injections in ampoules for injection). 1 ml contains 30 mg of thioctic (α-lipoic) acid.

Indications for use Octolipen

The drug Octolipen instructions for use recommends using for the treatment of polyneuropathy of diabetic and alcoholic origin.

It is also used for the following pathologies:

Hepatitis;
Cirrhosis of the liver;
Neuralgia of various localization;
Intoxication of the body with salts of heavy metals.

Numerous reviews of Octolipen show that it is used not only for polyneuropathies, but also for the most different states, when nervous system support required.

Instructions for use Octolipen, dosage

The dosage varies greatly: 50-400 mg / day. Sometimes the doctor prescribes up to 1000 mg, but this is rather an exception.

It is possible to carry out stepwise therapy: oral administration of the drug begins after a 2-4-week course of parenteral (infusion) administration of thioctic acid. The maximum course of taking tablets is 3 months.

To prepare a solution, 300-600 mg of the drug is dissolved in sodium chloride, the drug is administered intravenously. Therapeutic measures carried out once a day for two to four weeks. In the future, oral (oral) therapy is indicated.

Octolipen in the form of capsules is administered orally at 600 mg (2 caps.) 1 time / day. Capsules are taken in the morning, on an empty stomach, 30 minutes before the first meal, without chewing, drinking enough water. The duration of the course is determined only by the doctor.

Application features

Patients with a diagnosis diabetes it is necessary to monitor the dynamics of blood glucose levels, especially in the early stages of treatment with Octolipen.

There are no data on the effect of thioctic (α-lipoic) acid on the ability to drive precise mechanisms and vehicles.

If intravenous administration / infusion is carried out quickly, then there is a danger of an increase in intracranial pressure, problems with respiratory system, seizures. Due to the influence of Octolipen on platelet activity, bleeding may be initiated, petechial hemorrhages into the skin and mucous membranes.

The simultaneous use of food reduces the effectiveness of the drug.

The drug is sensitive to light, so the ampoules should be removed only immediately before use, that is, before infusion.

Patients taking the drug Octolipen should refrain from drinking any alcohol-containing liquids, because. ethanol and its metabolites reduce the therapeutic efficacy of thioctic acid.

When taking the drug Octolipen, the use of dairy products is not recommended (due to the calcium content in them). The interval between doses should be at least 2 hours.

Simultaneous administration of the drug Octolipen and preparations of iron, magnesium and calcium is not recommended (due to the formation of a complex with metals, the interval between administration should be at least 2 hours).

Side effects and contraindications Octolipen

Taking Octolipen in all forms of release can cause side effects. The most common of these are: allergies (dermatitis, anaphylactic shock), decreased glucose in the bloodstream, possible development of symptoms of hypoglycemia (due to improved glucose uptake), impaired work digestive system(dyspepsia), including nausea, vomiting, heartburn. The patient may experience headaches and migraines.

With the / in the introduction, the following may occur negative manifestations: pinpoint hemorrhages in the mucous membranes, skin, thrombocytopathy, hemorrhagic rash (purpura), thrombophlebitis.

Overdose

Symptoms: headache, nausea, vomiting. AT severe cases: psychomotor agitation or clouding of consciousness, generalized convulsions, hypoglycemia, acute skeletal muscle necrosis, multiple organ failure.

Treatment: symptomatic (including induction of vomiting, gastric lavage, taking activated carbon). There is no specific antidote.

Contraindications for all forms of release of the drug are the same:

pregnancy;
lactation period (breastfeeding);
children's and adolescence up to 18 years (efficacy and safety of use have not been established);
hypersensitivity to the components of the drug.

Oktolipen analogs, list

Thiolept;
Thiogamma;
Espa-lipon;
Alpha lipoic acid;
Lipamide;
Lipothioxone;
Neurolipon.

Important - instructions for use Octolipen, price and reviews to analogues have nothing to do and cannot be used as a guide or instruction. Any replacement of the drug Octolipen with an analogue should be under the supervision of the attending physician. Although this drug and its analogues are often used by women for weight loss, experienced doctor should warn you against such experiments, unless we are talking about a violation of carbohydrate and protein metabolism, as well as weight correction in diabetics.