Trypsin: instructions for use and what it is for, price, reviews, analogues. For which diseases is it effective? Contraindications and precautions

Latin name: trypsin
ATX code: D03BA01
Active substance:
Manufacturer: OOO Samson-med, Russia
Vacation from the pharmacy: On prescription
Storage conditions: up to 10 degrees
Best before date: 3 years.

The use of trypsin is indicated for various pathological conditions of infectious origin.

Indications for use

These include:

• lung abscess
• Iridocyclitis or iritis in the acute stage
• bronchiectasis
• Complications after surgical intervention in the eyes - hemorrhage or excessive swelling
• Purulent wounds and post-burn conditions
• Obstruction of tear ducts
• Pleurisy, emphysema
• sinusitis
• Postoperative atelectasis
• Chronic course of otitis media with exacerbation of purulent nature
• sinusitis with pus
• Thrombophlebitis in the acute stage
• Chronic or acute osteomyelitis
• Inflammatory process in the presence of periodontal disease
• Obstruction of the lacrimal ducts.

Composition and forms of release

Trypsin crystalline in the amount of 10 mg is in a glass vial, without additional auxiliary components.

One vial contains 10 mg of a white lyophilized powder for the preparation of an injection solution. One package contains 10 ampoules.

Medicinal properties

The drug has proteolytic pharmacological properties. Pharmacological group- proteolytics. The drug belongs to the group of enzymatic agents, as it is mechanically extracted from the pancreas of a large cattle. The drug has anti-exudative and anti-inflammatory pharmacological properties, well splits fibrinous formations, dead tissue areas, secretions from mucus and exudates. trypsin does not have dangerous effects in relation to healthy parts of the body, since in normal tissues to this substance, specific and non-specific resistance to this enzyme is produced. The drug does not affect the homeostasis system in any way. No data on pharmacokinetics.

Dosage and administration

average cost drug in Russia is - 800 rubles per pack.

Instructions for use indicate that the drug is suitable for local, inhalation, interpleural, intramuscular use. Often, trypsin is also used in electrophoresis methods. If you need to use the medicine topically, then prepare the powder for the compress. Diluted dry powder with a compress is applied to dry or dying areas of the tissue surface. To carry out this procedure, it is necessary to dilute 5 ampoules with trypsin in 5 ml of injection solution or physiological saline. Then, after treatment, a compress is applied on top, on which it is desirable to pre-pour an antiseptic like furacilin. Then a bandage of gauze is applied on top. It is recommended to change the bandage in a day, repeat the procedure until the process of complete cleansing of the wounds occurs. For complete cleansing, it is enough to apply from 1 to 3 compresses.

For aerosol use, inhalation is necessary. This requires using a bronchoscope or inhaler to inject 1-2 ampoules of the drug diluted in 2-3 ml of saline. After the administration of the drug and the end of the procedure, it is necessary to rinse the nose and mouth warm water. If you need to cook eye drops, then a 0.25% solution is used, which is prepared immediately before instillation. This procedure carried out 3-4 times a day for 1-3 days. The drug should be injected into the pleural cavity once a day. To begin with, use 10-20 mg of the drug, which is diluted in 20-50 ml of saline. After two days, the injected substance is eliminated. For intramuscular use, it is required to administer 5-10 mg 1-2 times a day. Children are allowed to use no more than half of the ampoule at a time. The duration of treatment is about a week, it is permissible to dilute the drug with procaine or sodium chloride. For electrophoresis, 1 ampoule is diluted with 10-20 ml of injection water.

During pregnancy and breastfeeding

Pregnant and lactating mothers this drug can only be prescribed under strict indications.

Contraindications and precautions

Contraindications for use:

• intolerance or hypersensitivity to the components of the drug
• Inflammation of the pancreas
• Emphysema
• Insufficiency of respiratory function
• Heart failure
• Hepatic dystrophy
• Diathesis hemorrhagic
• Decompensation form of pulmonary tuberculosis
• Cirrhosis of the liver
• kidney disease
• Hepatitis of infectious origin.

Cross-drug interactions

Interactions with other drugs: it is only when used in inhaled form, when bronchodilators or antibacterial drugs can be added.

Side effects

These include:

• Accelerated pathological heartbeat
• allergic reactions
• Redness and soreness at the injection site
• hyperthermia
• sat down, hoarse voice, which occurs when the mucous membrane of the throat is irritated after inhalation.

Overdose

There is no data on overdose.

Trypsin analogues

Samson-Med, Russia

average cost drug - 700 rubles per pack.

Ribonuclease - proteolytic enzyme preparation which is suitable for local use. Like its main analogue, ribonuclease is synthesized by extracting preliminary sampling material from the pancreas of cattle. The essence of the action of the drug is to liquefy various thick slimy formations: sputum, mucus, pus. The drug has a powerful anti-inflammatory pharmacological effect. Indications for use: pleurisy, osteomyelitis, thrombophlebitis, meningitis viral origin, tick-borne encephalitis, ear infection, trophic ulcer, gingivitis, lung abscess. Usually the drug is well tolerated and rarely causes side effects.

Pros:

• Ease of use
• Suitable for many people to use.

Minuses:

• Efficacy not proven
• There may be side effects.

ZAO Vifitech, Russia

average cost- 200 rubles per package.

Aloe extract liquid can be attributed to natural biogenic stimulants plant origin based injection solution. The medicine increases defensive forces organism, promotes speedy recovery after a previous infectious disease, improves immunity, has a positive effect on the condition of the visual organs. Also, aloe extract can be used to correct various pathological conditions in the gynecological field.

Pros:

• Good tolerance
• Natural origin.

Minuses:

• Efficacy not proven
• With prolonged use, it flushes out potassium from the body.

Russian name

Latin name for the substance Trypsin

Pharmacological group of substance Trypsin

Nosological classification (ICD-10)

CAS code

Characteristics of the substance Trypsin

Endogenous proteolytic enzyme of the hydrolase class, catalyzes cleavage, incl. proteins, peptones, low molecular weight peptides by bonds, in the formation of which the carboxyl groups of L-arginine and L-lysine take part. Trypsin is a protein with a relative molecular weight 21000 is produced and secreted by the mammalian pancreas as inactive trypsinogen, which is then converted to trypsin by the enzyme enteropeptidase in the duodenum.

Trypsin is obtained from the pancreas of cattle, followed by lyophilization. AT medical practice apply crystalline trypsin (allowed for both local and parenteral use) and amorphous trypsin (only for topical use).

Crystalline trypsin is a white or white with a slightly yellowish tint powder, odorless, or a porous mass (after lyophilization). Easily soluble in water isotonic solution sodium chloride; solutions are easily destroyed in a neutral and alkaline environment.

Special dosage forms crystalline trypsin for the treatment of purulent wounds - trypsin is immobilized on special polymer bases (cloth): on dialdehyde cellulose or on activated knitted polyamide fabric; fabric cuts are produced in sizes from 10 × 7.5 cm to 30 × 20 cm.

Pharmacology

With local application, it has anti-inflammatory, anti-burn, regenerating and necrolytic effects. It splits necrotic tissues and fibrinous formations, dilutes viscous secrets, exudates, blood clots. The enzyme is active at pH 5.0-8.0 with an optimum action at pH 7.0. In relation to healthy tissues, it is inactive and safe due to the presence of trypsin inhibitors in them - specific and nonspecific.

Immobilized crystalline trypsin contributes to the rejection of necrotic tissues, liquefies pus and facilitates its evacuation, improves the process of wound regeneration. Unlike non-immobilized crystalline trypsin, it does not cause changes in the hemostasis system.

At inflammatory diseases respiratory tract trypsin thins and facilitates the removal of viscous secrets and exudates with sputum. In these cases, it is used for inhalation and / m. With exudative pleurisy and pleural empyema, it can be administered intrapleurally. With tuberculous empyema, care should be taken because the resorption of exudate in some cases may contribute to the development of a bronchopleural fistula.

The anti-inflammatory effect causes the use of crystalline trypsin intramuscularly in thrombophlebitis (trypsin does not replace anticoagulants), inflammatory-dystrophic forms of periodontal disease, etc.

For eye diseases, it is used intramuscularly and topically (in the form of eye drops and baths).

For the treatment of burns, bedsores, purulent wounds, trypsin is used topically.

In dentistry, it is used for ulcerative-necrotic diseases of the oral mucosa, periodontal diseases, periodontitis, odontogenic sinusitis, etc.

Application of the substance Trypsin

Respiratory tract diseases (including tracheitis, bronchitis, bronchiectasis, pneumonia, postoperative lung atelectasis, pleural empyema, exudative pleurisy), thrombophlebitis, periodontal disease (inflammatory-dystrophic forms), osteomyelitis, sinusitis, otitis media, iritis, iridocyclitis, hemorrhage in the anterior chamber of the eye, swelling of the periorbital region after operations and injuries, burns, bedsores; festering wounds(locally).

Contraindications

For injection- cardiac decompensation, pulmonary emphysema with respiratory failure, decompensated forms of pulmonary tuberculosis, liver dystrophy, liver cirrhosis, infectious hepatitis, pancreatitis, hemorrhagic diathesis. Do not inject into bleeding cavities, intravenously, apply to ulcerated surfaces of malignant tumors.

One vial contains 10 mg trypsin crystalline.

Release form

Trypsin is available in the form of a lyophilizate (powder) for the preparation of a local and injection solution. One package contains 10 vials.

pharmachologic effect

Proteolytic.

Pharmacodynamics and pharmacokinetics

Trypsin is a proteolytic enzyme drug extracted from pancreas cattle. Crystalline Trypsin exhibits a pronounced anti-inflammatory and anti-edematous effect, has the properties of splitting fibrinous formations , dead tissue areas, viscous exudates and secrets . Trypsin is safe and inactive against healthy tissues due to the presence of inhibitors given enzyme (both specific and non-specific). Also, the drug does not affect the system hemostasis .

Indications for use

• lung abscesses ;
• bronchiectasis;
• purulent burns and wounds;
• pleural empyema ;
• postoperative atelectasis ;
• exudative pleurisy ;
• purulent chronic otitis media ;
• sinusitis ;
• purulent sinusitis ;
• sharp thrombophlebitis ;
• odontogenic osteomyelitis chronic and acute course;
• periodontal disease in inflammatory-dystrophic form;
• obstruction of the lacrimal ducts;
• complications of the organs of vision due to operations or injuries (swelling of the periorbital region, hemorrhages in the eye chamber);
• irites and iridocyclitis in acute form.

Contraindications

Side effects

Crystalline Trypsin, instructions for use

As local drug prepare a solution or powder for compresses. On the necrotic or dry wound surfaces are applied with compresses with a freshly prepared solution. For this 50 mg trypsin diluted in 5 ml of saline or water for injection (for therapy wounds with purulent lesions use the same amount phosphate buffer solution ). After treatment of the wound, a three-layer fabric cloth (compress) made of dialdehyde cellulose, pre-impregnated with trypsin and soaked in solution Furacilina or distilled water. The compress is fixed with a gauze bandage and left, as a rule, for no more than 24 hours. For complete cleansing wound surfaces from purulent discharge and necrotic tissues one to three compresses (24-72 hours) are usually required. If necessary, repeated procedures are possible.

Used as an aerosol trypsin inhalation. Through bronchoscope or inhaler 5-10 mg of the drug dissolved in 2-3 ml of 0.9% NaCl solution are injected. At the end of the procedure inhalation need to rinse oral cavity and nasal passages warm water.

For use as eye drops, a 0.2-0.25% solution is used, prepared immediately before instillation, which is carried out 3-4 times a day for 1-3 days.

Intrapleural administration is carried out 1 time in 24 hours. Assign 10-20 mg of the drug diluted in 20-50 ml of 0.9% NaCl solution. After the end of the procedure, it is recommended frequent shift body position. As a rule, on the 2nd day after administration, the already dissolved exudate .

Intramuscular injections for adults appoint in a dose from 5 to 10 mg with introduction 1-2 times a day. Recommended disposable daily dose for children is 2.5 mg. Directly before use, a solution is prepared, for which 5 mg of the drug is diluted in 1-2 ml of a 0.9% NaCl solution or a 0.5-2% solution Procaine . Usually the course of therapy takes 6-15 injections.

For the use of the drug in the process of carrying out electrophoresis , it is recommended to use 10 mg of drugs diluted in 15-20 ml of purified water for one procedure.

Overdose

Cases of overdose with Crystalline Trypsin have not been described.

Interaction

The interaction of the drug is possible only when carrying out inhalations , where it is possible to add to the prepared solution antibiotics and bronchodilators (on the recommendation of a doctor).

Terms of sale

Trypsin crystalline dispensed from pharmacies upon presentation of a prescription.

Storage conditions

Trypsin is stored in a dry, dark place at a temperature not exceeding 10°C.

Best before date

36 months.

special instructions

The drug should not be injected into bleeding cavities and foci of inflammation.

Avoid application to ulcerated areas malignant formations , due to the possible spread tumor process .

Do not under any circumstances administer intravenously.

Analogues

Coincidence in the ATX code of the 4th level:

collalizin , Lysoamidase , Protolysin , Profezim , Ribonuclease , Terrilithin , Chymopsin , Chymotrypsin .

The most famous analogue of Trypsin, as well as its "competitor", is Chymotrypsin . In order to understand the difference or similarity of these two drugs, it is necessary to understand how they get trypsin what is it and how does it differ from chymotrypsin . Without going into subtle nuances, it is worth noting that trypsin and chymotrypsin are proteolytic enzymes , both stand out from pancreas livestock and both hydrolyze protein . In medical practice, they are used for the same indications, in which they show an almost equal result. Unlike trypsin , chymotrypsin in some cases deeper hydrolyzes protein , slower inactivated and is revealed to be more persistent, therefore, in some situations it can be more effective than its main “competitor”.

children

It is used in children according to indications and recommended doses.

During pregnancy and lactation

Application during periods breastfeeding and pregnancy possible only taking into account all possible risks.

Instructions for use Trypsin

"Trypsin" - a drug a wide range actions. The specific composition of the product is designed to provide anti-edematous and anti-inflammatory effects on the body. Medicine belongs to the group of proteolytic drugs used in a medical institution.

Composition and form of release

The enzyme preparation of proteolytic action contains crystalline trypsin, a substance found in the pancreas of cattle.

The product is produced in the form of a lyophilizate - a powder for diluting the solution. One vial contains a powder containing 10 mg active component. The package contains 10 bottles of lyophilisate.

pharmachologic effect

Trypsin crystalline due to complex impact promotes breakdown:

• fibrous formations;
• dead cells;
• viscous secretions and exudates.

The drug is safe for healthy tissues.

Indications

Use "Trypsin" instructions for use recommends for many indications. The active ingredient is effective for the treatment of diseases:

• lung abscesses;
• burn and purulent wounds;
• exudative pleurisy and pleural empyema;
• purulent sinusitis and chronic otitis media;
• bronchiectatism;
• osteomyelitis and thrombophlebitis (acute and chronic form);

• postoperative atelectasis;
• inflammatory and dystrophic form of periodontal disease;
• blockage of the tear ducts;
• complication after injury or eye surgery;
• iridocyclitis or iritis (exacerbation).

Contraindications

The solution is not prescribed for use when diagnosing deviations in a patient:

• drug sensitivity;
• pulmonary insufficiency, accompanied by the formation of eczema;
• lack of blood supply to the heart;
• renal dystrophy;
• diathesis hemorrhoidal;
• pancreatitis;
• pulmonary tuberculosis (decompensation);
• hepatic cirrhosis;
• infectious hepatitis.

Treatment with Trypsin, if there are contraindications, leads to a complication of the patient's condition.

Side effect

AT rare cases when using "Trypsin" occurs side effect as:

• hyperemia of the skin;
• soreness at the injection site;
• tachycardia;
• allergic reaction;
• raising the overall temperature;
• irritation of the oral mucosa.
• increase in body temperature;

The side effect of the drug is temporary. Cancel medical procedures with the use of "Trypsin" due to side effect possible at the discretion of the physician. Overdose active ingredient was not observed.

Instruction

The use of the solution "Trypsin" is carried out in several ways. The nature of the procedure depends on the indications.

Procedure options:

• compresses for external lesions of soft tissues;
• inhalation;
• eye drops;
• intrapleural introduction;
• intramuscular injections;
• addition to electrophoresis.

Any form of procedure must be carried out in a hospital setting.

Application Features:

• For local use, the lyophilizate is used in the form of a powder or solution for making a compress. To prepare a solution, mix medicinal powder(50 mg) with water for injection (5 ml). The gauze lining is moistened with the agent and applied to the affected area and fixed with a bandage. Max Time impact - days.
• For inhalation, the solution is poured into a special apparatus. To prepare the medicine, 10 mg of "Trypsin" is mixed with 3 ml of sodium chloride 9%.
• Eye drops are made from a 0.25% solution of the drug. Use 4 times a day.

• Introduction intrapleural is carried out no more than once a day. It is recommended to administer 10/20 mg of a solution diluted in 9% sodium chloride.
• Injections are administered intravenously twice a day, 10 mg of the solution. The lyophilizate is diluted in sodium chloride 0.9%. The average course is 10 procedures.
• To conduct an electrophoresis session, a solution of trypsin powder (10 mg) in water (10 ml) is used.

The treatment regimen is determined individually. The manual describes only general recommendations.

special instructions

The drug "Trypsin" is used in accordance with the recommendations:

• do not apply at the site of bleeding wounds;
• topically, the agent is not applied to areas of cancerous tumors;
• do not enter intravenously;
• for the treatment of children is used according to an individual scheme;
• use during pregnancy/lactation increased risks for the life of a woman or a fetus.

Drug interaction of the drug is possible only with inhalation use.

Analogues

Only a doctor can replace Trypsin with an analogue.

The following are considered analogues of funds:

• "Terrilytin";
• "Protolysin";
• "Chymotrypsin";
• "Lysoamidase";
• "Ribonuclease".

The direct analogue of the original is "Chymotrypsin". According to many experts, the substitute for "Trypsin" - "Chymotrypsin" has a greater effect in the course of therapy.

Cost and terms of purchase

In different pharmacies for Trypsin, the price may vary. The average cost is 500 rubles.