Nice reception. Contraindications for the use of the drug. Side effects of Nise

One of available funds is Nise for toothache. We will briefly describe the instructions for use, tell you if it really helps, clarify the price and provide feedback from those people who often use just such a medicine in daily practice.

Painful sensations from a diseased tooth, probably, at least once in a lifetime, worried every inhabitant of the planet. And while there is no way to quickly get an appointment with a doctor, you need to reduce the intensity unpleasant symptoms and alleviate your condition. Today, the pharmacy sells many drugs that can help in such a situation.

Composition and form of release

This medicine is found in several varieties - tablets (simple and soluble) and in suspension. The first option is more suitable for adult patients and has several dosages - 50 mg or 100 mg each. For children who weigh less than 40 kg, it is acceptable to take Nise only in the form of a suspension. In this case, the amount of the drug should be accurately calculated from the calculation of the volume of the active substance per 1 kg of weight.

The main active ingredient is nimesulide. It is he who influences pain, dulling them. The rest of the elements are optional:

1. Aspartame.
2. Silicon dioxide.
3. calcium phosphate.
4. Cellulose microcrystalline.
5. Fruit flavored fragrance.
6. Talc.

In pharmacies, you can also find Nise gel for external use, designed to eliminate various painful symptoms with diseases of the suglobs, ligaments, muscles and bones, their inflammation and the appearance of edema.

Principle of operation and indications

What helps Nise? Its effect on the body is considered complex:

• brings down the temperature;
• acts as an analgesic;
• relieves manifestations of inflammation;
• reduces sensitivity to pain;
• eliminates swelling of soft tissues;
• acts as an antioxidant.

The active substance quickly enters the bloodstream and begins to act within 15-20 minutes after taking the pill. The maximum concentration is reached after 1-1.5 hours and the analgesic effect lasts up to 4-5 hours in a row. Excreted from the body by the kidneys.

• with pains of a dental nature, even of high intensity;
• after tooth extraction;
• with migraines;
• if they bother discomfort during the menstrual cycle;
• to eliminate pain in muscles and ligaments, for example, from sprains or ruptures;
• with arthralgia;
• lumbago;
• ankylosing spondylitis;
• at sharp pains in the back or lower back, for example, in cases of sciatica, osteochondrosis, etc.;
• to reduce inflammatory phenomena in joints or tendons;
• with rheumatism;
• after injury or surgery;
• to lower body temperature as a result of infectious or viral diseases.

This drug acts quickly and eliminates pain symptoms in short term even at medium or high intensity. Tablets Nise with toothache, not only stop nerve endings, but also eliminate inflammatory processes in the surrounding tissues, relieve swelling of the gums. But you need to understand that this action is only temporary and does not eliminate the very causes and signs of the disease. Therefore, the pain will return again if you do not visit the dentist.

Contraindications and side effects

In addition to information about what the drug affects, how long it takes and in what dosage to use it, you must definitely familiarize yourself with its contraindications. It is strictly forbidden to use Nise for persons with such health problems:

• violations of the digestive organs;
• with intestinal infections;
• stomach ulcers;
• internal bleeding;
• kidney or liver disease;
• diagnosis of hepatitis of any form;
• frequent dermatoses;
• seizures bronchial asthma;
• during pregnancy or while breastfeeding;
• with eye diseases;
• heart disorders, circulatory system and capillaries;
• frequent drops blood pressure;
• with polyps;
• allergic reaction to medical preparations, especially on aspirin;
• low blood clotting;
• until the child reaches the age of two.

It is strictly forbidden to combine Nise with alcohol and many medicines. In some cases, for example, in case of overdose or too long-term use such side effects:

• vomiting or nausea;
• migraines and dizziness;
• skin rashes, like an allergic reaction;
• increased drowsiness, weakness;
• heartburn;
• liquid "stool";
• the appearance of signs of toxic hepatitis;
• sudden changes in blood counts - anemia, low level leukocytes, thrombocytopenia, etc.;
• at severe allergies anaphylactic shock.

How to take Nise for toothache?

Before using this tool, you should carefully read the instructions for use. It necessarily describes in what dosages we can take the medicine, as well as how many days you can drink it without danger to health.

Tablets

Adult patients and children over 12 years of age can use the tablet form of the drug. The daily intake should not exceed four times, preferably at the same interval. Be sure to take your medicine large quantity water. Pay attention to concentration active substance in one tablet (50 or 100), so as not to exceed the permissible doses.

If Nise has a dispersible form, that is, it dissolves in water, a teaspoon of liquid is enough for this. Due to this, the drug is absorbed faster and stronger by the body, and its effect occurs after more short span time. In any case, it is advisable to take the tablet after a meal.

Suspension

Children under 12 can be given this remedy only in suspension. Required amount is calculated strictly according to the weight of the child. So, 5 mg active component multiplied by each kg of mass. The resulting figure must be divided into two or four doses and converted into ml of suspension. Most often, the instructions have approximate parameters for each age group with the already calculated amount of the drug.

Take the remedy for both adults and children, you can not longer than 10 days. Keep in mind that Nise is not able to cure the underlying problem of the disease and only temporarily eliminates pain. Therefore, you should visit your doctor for a consultation as soon as possible.

Overdose symptoms

All of the above side effects in one form or another indicate either intolerance to the drug and its components, or an excess allowable doses. For any unpleasant sensations you should consult a doctor and stop taking the medicine.

The main symptoms of an overdose are increased blood pressure, convulsions, rapid or labored breathing. With such manifestations, it is desirable to quickly remove the drug from the body. To do this, you need to wash your stomach. accessible way and take any sorbents on hand.

What drugs can not be combined with?

Nise is often prescribed for complex treatment with anti-inflammatory drugs, antibiotics and antihistamines. But not every drug can be combined with it. It is unacceptable to use Nise in one period with:

• hypoglycemic drugs;
• anticoagulants;
• Phenytoin;
• diuretics;
• Digoxin;
• means for pressure reduction;
• cyclosporins;
• anti-inflammatory nonsteroidal drugs.

Analogues

As you know, in modern pharmacies, a great variety of similar painkillers are sold. Which one to choose and which is better? Let's offer a few more effective drugs from toothache, which have a similar effect to Nise:

• Nimesil - is sold both in the form of a soluble powder and in tablets. Helps relieve tissue inflammation and relieves pain.
• - An excellent pain reliever based on ibuprofen. Quickly and permanently relieves pain of any localization. For children, it is available in the form of syrup.
• Ketonal - strong remedy designed to reduce any pain.
• Aponil - has a low cost compared to other analogues.
• - pills that have been known for many years, but carry some health risks when taken for a long time. Today, doctors are less and less prescribing them for treatment.

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Miracle drug.

Nimesan saved me from pain in my legs. I drank for two weeks, and for half a year they have not tormented me. Miracle drug. Nimesan saved me from pain in my legs. I drank for two weeks, and for half a year they have not tormented me. Miracle drug.


You have to give credit to this drug.

I have Nimesan on Emergency, for example, when cervical osteochondrosis does not even allow you to raise your hand or simply turn your head to look around. We must pay tribute to this drug - it works instantly. I have Nimesan for an emergency, for example, when cervical osteochondrosis does not even allow me to raise my hand or simply turn my head to look around. We must pay tribute to this drug - it works instantly.


Nimesan is an excellent drug.

Nimesan is an excellent drug. My wrist hurt after playing tennis. It's so strong that it's unbearable. took a pill. Started working within a minute. And the wrist turned out to be dislocated, then he went to treat it. Nimesan is an excellent drug. My wrist hurt after playing tennis. It's so strong that it's unbearable. took a pill. Started working within a minute. And the wrist turned out to be dislocated, then he went to treat it.


Nimesan proved to be very effective.

I have been suffering from osteochondrosis for several years now. It starts with a pain in the neck, and develops into a headache, which is already nauseating. Tried Nise - did not help. Friends suggested trying Nimesan. I suffered so much that I would have agreed to an axe. But surprisingly, Nimesan turned out to be very effective. An hour later, all I had left was slight discomfort... I have been suffering from osteochondrosis for several years now. It starts with a pain in the neck, and develops into a headache, which is already nauseating. Tried Nise - did not help. Friends suggested trying Nimesan. I suffered so much that I would have agreed to an axe. But surprisingly, Nimesan turned out to be very effective. An hour later, I was left with only a slight discomfort in my neck. I no longer have wild pains and sleepless nights.


Thank you doctor for good recipe.

At work, it was necessary to move a lot, including stairs. So the pain in the knee just killed. I went to the doctor, he advised Nimesan. Excellent drug. Now I can run all day and not worry about pain. Thank you doctor for a good prescription. At work, it was necessary to move a lot, including stairs. So the pain in the knee just killed. I went to the doctor, he advised Nimesan. Excellent drug. Now I can run all day and not worry about pain. Thank you doctor for a good prescription.


The tool is good

At work, I usually sit at random. And here I sat. Pinched the lower back. I thought it would be released soon. And no, it hurt so much that I could barely walk. On the way I went to the pharmacy, bought Nimesan, I have long been familiar with it, it helps a lot. By the time I got home, the pain was gone. The tool is good, but you need to do something with your sedentary ... At work, I usually sit at random. And here I sat. Pinched the lower back. I thought it would be released soon. And no, it hurt so much that I could barely walk. On the way I went to the pharmacy, bought Nimesan, I have long been familiar with it, it helps a lot. By the time I got home, the pain was gone. The tool is good, but you need to do something with yours in a sedentary manner life.


Excellent drug.

A couple of years ago, my sister and I were walking down the street and her back hurt. All in tears, she went to the pharmacy and asked for at least something to help with the pain. They gave me Nimesan. But I did not expect such an effect. After a couple of minutes, she felt better. And after half an hour, she almost forgot about ... A couple of years ago, my sister and I were walking down the street and her back hurt. All in tears, she went to the pharmacy and asked for at least something to help with the pain. They gave me Nimesan. But I did not expect such an effect. After a couple of minutes, she felt better. And after half an hour, she almost forgot about the pain. Of course, the back cannot be started and you need to go to the doctor and be examined. But just like that, it was the right choice.


What do you say, what experience do you have?

I am only 32 years old and suffer from constant pain in the neck. Doctors all say each his own as usual. I got hooked on painkillers, tried, of course, almost everything that is in pharmacies. So I share my expert experience: Nimesan is on my this moment"numero uno". Always effective, great help, and the price... I am only 32 years old and suffer from constant pain in my neck. Doctors all say each his own as usual. I got hooked on painkillers, tried, of course, almost everything that is in pharmacies. So I share my expert experience: “Nimesan” I currently have “numero uno”. It always works effectively, helps a lot, and the price is several times lower than that of analogues. What do you say, what experience do you have?


It turned out - helps.

Got into a car accident. It's okay, it just flew into the driver's door. He himself is intact, only a blow flew to the leg. In general, the leg then delivered some inconvenience. Until my sister pushed Nimesan into me almost by force. At first I didn’t want to - I thought triangular stuff, some kind of dietary supplements. It turned out - helps. Took it until it's gone... Got into a car accident. It's okay, it just flew into the driver's door. He himself is intact, only a blow flew to the leg. In general, the leg then delivered some inconvenience. Until my sister pushed Nimesan into me almost by force. At first I didn’t want to - I thought triangular stuff, some kind of dietary supplements. It turned out - helps. I took it until my leg passed and I felt good.


Works great and not expensive.

More recently, if something hurts, I endured it until it passes. My brother always drank Nimesan for pain. And recently I read an article that pain cannot be tolerated. Now I’m treating a little something with Nimesan. Works great and not expensive. Did someone take it? More recently, if something hurts, I endured it until it passes. My brother always drank Nimesan for pain. And recently I read an article that pain cannot be tolerated. Now I’m treating a little something with Nimesan. Works great and not expensive. Did someone take it?


I liked.

I advise everyone to take Nimesan. Earned an elbow injury playing badminton in the yard. It seems that the elbow was treated, but for some reason inflammation began. My elbow hurt incredibly. The doctor prescribed Nimesan. I drank it and there was no pain at all. Plus I drank antibiotics, so the elbow soon passed. I advise everyone to take Nimesan. Earned an elbow injury playing badminton in the yard. It seems that the elbow was treated, but for some reason inflammation began. My elbow hurt incredibly. The doctor prescribed Nimesan. I drank it and there was no pain at all. Plus I drank antibiotics, so the elbow soon passed.


Helped!

Constantly people who grumble and look down on people with frequent and severe headaches. But it's not a pretense. For example, I had such pains from which I fainted at all. I can't even move because of it. But one good friend advised Nimesan. He's certainly not magical. Constantly people who grumble and look down on people with frequent and severe headaches. But it's not a pretense. For example, I had such pains from which I fainted at all. I can't even move because of it. But one good friend advised Nimesan. He certainly doesn't Magic wand and the pain didn’t completely go away, but at least it relieves it enough that I can live with it. I'm planning to go for an MRI, it's scary.


For us it perfect option.

After the operation, my father had severe pain for a long time. Rather, the first couple of days there were pains, until my mother found the right medicine - "nimesan", which helped a lot. He no longer had any pain. The main thing is to take it on time. For about a couple of weeks he had to take medicine, I was afraid there would be side effects with the stomach .... After the operation, my father was in severe pain for a long time. Rather, the first couple of days there were pains, until my mother found the right medicine - "nimesan", which helped a lot. He no longer had any pain. The main thing is to take it on time. For about a couple of weeks he had to take medicine, he was afraid there would be side effects with the stomach. My mother herself at one time had this with another drug. But here everything went off without a hitch. For us, this is ideal.


What do you think?

I don't understand how drug prices are set! The price of almost identical drugs can differ by an order of magnitude. One is under a thousand, the other is a hundred and something rubles. At one time he took painkillers, anti-inflammatory drugs, and so there was such a scatter. "Nimesan" - affordable, "Nimesil" - very expensive. BUT active substance one. AND... I don't understand how drug prices are set! The price of almost identical drugs can differ by an order of magnitude. One is under a thousand, the other is a hundred and something rubles. At one time he took painkillers, anti-inflammatory drugs, and so there was such a scatter. "Nimesan" - affordable, "Nimesil" - very expensive. There is only one active ingredient. And there is no difference in effect. What do you think?


As a result, we are satisfied with the choice - it helped out more than once.

My family and I love tourism, we go hiking with friends. It is clear that you need to collect a first aid kit with you, and carefully select medicines in it: to be effective, inexpensive, without any side effects. The most difficult thing was to choose the right painkiller and anti-inflammatory. Through trial and error, they found "NIMESAN": there the active substance is nimesulide, as ... My family and I love tourism, we go hiking with friends. It is clear that you need to collect a first aid kit with you, and carefully select medicines in it: to be effective, inexpensive, without any side effects. The most difficult thing was to choose the right painkiller and anti-inflammatory. Through trial and error, they found NIMESAN: there the active substance nimesulide, as in Nise, only Nimesan costs less. As a result, we are satisfied with the choice - it helped out more than once.

Tablets

Indications for the use of the drug Nise

inflammatory and degenerative diseases musculoskeletal system(articular syndrome with rheumatism and exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthrosis, osteochondrosis with radicular syndrome, sciatica, inflammatory lesions of the ligaments, tendons, bursitis; sciatica, lumbago);

Muscular pain of rheumatic and non-rheumatic origin;

Post-traumatic inflammation of soft tissues and the musculoskeletal system (damages and ruptures of ligaments, bruises).

Form of release of the drug Nise

tablets 100 mg; blister 10 cardboard pack 2;
tablets 100 mg; blister 10 cardboard pack 10;
tablets 100 mg; blister 10 cardboard pack 1;

Pharmacodynamics of the drug Nise

absorption when taken orally is high. Eating reduces the rate of absorption without affecting its degree. The time to reach Cmax of the active substance in blood plasma is 1.5–2.5 hours. Plasma protein binding is 95% (for dispersible tablets - 99%), with erythrocytes - 2%, with lipoproteins - 1%, with acidic alpha1- glycoproteins - 1%. The dose of the drug does not affect the degree of binding. Cmax nimesulide in plasma reaches 3.5-6.5 mg / l. Vd - 0.19–0.35 l / kg. It penetrates into the tissues of the female genital organs, where, after a single dose, its concentration is about 40% of the plasma concentration. It penetrates well into the acidic environment of the focus of inflammation (40%), synovial fluid(43%). Easily penetrates through histohematic barriers. Metabolized in the liver by tissue monooxygenases. The main metabolite, 4-hydroxynimesulide (25%, has a similar pharmacological activity, but due to a decrease in the size of the molecules, it can quickly diffuse through the COX-2 hydrophobic channel to the active site of binding the methyl group. 4-hydroxynimesulide is a water-soluble compound that does not require glutathione and conjugation reactions of the II phase of metabolism (sulfation, glucuronidation, etc.).

T1 / 2 nimesulide is 1.56-4.95 hours, 4-hydroxynimesulide - 2.89-4.78 hours. 4-hydroxynimesulide is excreted by the kidneys (65%) and bile (35%). In patients with renal insufficiency (Cl creatinine 1.8-4.8 l / h or 30-80 ml / min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide does not change significantly.

Pharmacokinetics of the drug Nise

NSAIDs from the sulfonanilide class. It is a selective competitive inhibitor of COX-2, inhibits the synthesis of PG in the focus of inflammation. The inhibitory effect on COX-1 is less pronounced (rarely causes side effects associated with inhibition of PG synthesis in healthy tissues). It has anti-inflammatory, analgesic and antipyretic effects.

Nimesulide is able to inhibit the synthesis of IL-6 and urokinase, preventing the destruction cartilage tissue. Inhibits the synthesis of metalloproteinases (elastase, collagenase), preventing the destruction of proteoglycans and collagen in cartilage tissue.

It has antioxidant properties, inhibits the formation of toxic oxygen decay products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them by phosphorylation, which also enhances the anti-inflammatory effect of the drug.

Use of Nise during pregnancy

Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.

Use of Nise for impaired renal function

Patients with chronic renal failure require a reduction daily dose up to 100 mg.

Contraindications to the use of the drug Nise

hypersensitivity to nimesulide or auxiliary components of the drug;
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance acetylsalicylic acid and other NSAIDs (including history);
erosive and ulcerative lesions GI tract and duodenum(in the acute phase), active gastrointestinal bleeding;
cerebrovascular or other bleeding;
inflammatory diseases intestines (Crohn's disease, non-specific ulcerative colitis) in the acute phase;
hemophilia and other bleeding disorders;
decompensated heart failure;
liver failure or any active disease liver;
anamnestic data on the development of hepatotoxic reactions when using nimesulide preparations;
concomitant use potentially hepatotoxic substances;
alcoholism;
addiction;
pronounced kidney failure(Cl creatinine<30 мл/мин), прогрессирующие заболевания почек;
confirmed hyperkalemia;
the period after coronary artery bypass grafting;
pregnancy;
lactation period;
children's age up to 12 years (see "Special Instructions").

Carefully:
ischemic heart disease;
cerebrovascular diseases; congestive heart failure;
dyslipidemia/hyperlipidemia;
diabetes;
peripheral arterial disease;
smoking;
Cl creatinine -<60 мл/мин;
anamnestic data on the development of ulcerative lesions of the gastrointestinal tract;
presence of Helicobacter pylori infection;
elderly age;
prolonged use of NSAIDs;
severe somatic diseases;
frequent use of alcohol;
concomitant therapy with anticoagulants (eg warfarin), antiplatelet agents (acetylsalicylic acid, clopidogrel), oral corticosteroids (eg prednisolone), SSRIs (citalopram, fluoxetine, paroxetine, sertraline).

Side effects of Nise

The frequency is classified into rubrics, depending on the occurrence of the case: very often (> 10), often (<10–<100), нечасто (<100–<1000), редко (<1000–<10000), очень редко (<10000).

Allergic reactions: rarely - hypersensitivity reactions, very rarely - anaphylactoid reactions.

From the side of the central nervous system: infrequently - dizziness; rarely - a feeling of fear, nervousness, nightmares; very rarely - headache, drowsiness, encephalopathy (Reye's syndrome).

From the skin: infrequently - itching, rash, increased sweating, rarely - erythema, dermatitis; very rarely - urticaria, angioedema, swelling of the face, erythema multiforme exudative, incl. Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the urinary system: infrequently - edema; rarely - dysuria, hematuria, urinary retention, hyperkalemia; very rarely - renal failure, oliguria, interstitial nephritis.

From the gastrointestinal tract: often - diarrhea, nausea, vomiting; infrequently - constipation, flatulence, gastritis; very rarely - abdominal pain, stomatitis, tarry stools, gastrointestinal bleeding, ulcers and / or perforation of the stomach or duodenum.

From the side of the liver and biliary tract: often - an increase in the level of hepatic transaminases; very rarely - hepatitis, fulminant hepatitis, jaundice, cholestasis.

On the part of the hematopoietic organs: rarely - anemia, eosinophilia; very rarely - thrombocytopenia, pancytopenia, purpura, prolongation of bleeding time.

From the respiratory system: infrequently - shortness of breath; very rarely - bronchial asthma, bronchospasm.

From the senses: rarely - blurred vision.

From the side of the CCC: infrequently - arterial hypertension; rarely - tachycardia, hemorrhages, hot flashes.

Others: rarely - general weakness; very rarely - hypothermia.

Method of application and dose of the drug Nise

Inside, with a sufficient amount of water, preferably after (tablets) and before (dispersible tablets) meals. In the presence of diseases of the gastrointestinal tract, it is advisable to take the tablets at the end or after a meal.

The lowest effective dose should be used for the shortest possible course.

Adults and children over 12 years old - 1 tab. 2 times a day. The maximum daily dose for adults is 200 mg.

Overdose with Nise

Symptoms: apathy, drowsiness, nausea, vomiting. They are usually reversible with supportive care. Perhaps the development of gastrointestinal bleeding, arterial hypertension, acute renal failure, respiratory depression.

Treatment: symptomatic, supportive patient care; if an overdose has occurred within the last 4 hours - induction of vomiting, the appointment of activated charcoal (60-100 g per adult), osmotic laxatives. Forced diuresis, hemodialysis are ineffective due to the high level of protein binding. There is no specific antidote.

Interactions of the drug Nise with other drugs

The effect of drugs that reduce blood clotting is enhanced by their simultaneous use with nimesulide.

Nimesulide may reduce the effect of furosemide; increase the development of side effects while taking methotrexate.

The level of lithium in plasma increases with the simultaneous administration of lithium preparations and nimesulide.

Use with corticosteroids, SSRIs increases the risk of gastrointestinal bleeding.

Due to the high degree of binding of nimesulide to plasma proteins, patients who are simultaneously treated with hydantoin and sulfonamides should be under the supervision of a physician, undergoing examination at short intervals.

Nimesulide may enhance the effect of cyclosporine on the kidneys.

Special instructions when taking the drug Nise

Since Nise® is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced depending on the level of urination. Given reports of visual impairment in patients taking other NSAIDs, treatment should be stopped immediately if any visual impairment occurs and the patient should be examined by an optometrist.

The drug can cause fluid retention in the tissues, so patients with high blood pressure and impaired cardiac activity Nyz should be used with extreme caution.

Patients should undergo regular medical supervision if they take medications along with nimesulide, which are characterized by an effect on the gastrointestinal tract.

If there are signs of liver damage (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased levels of hepatic transaminases), you should stop taking the drug and consult your doctor. Do not use the drug simultaneously with other NSAIDs.

The drug can change the properties of platelets, but does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

Nise should be used with caution in patients who have a history of bleeding, in patients with upper gastrointestinal disease, or in patients receiving drugs that reduce blood clotting or inhibit platelet aggregation.

The use of the drug may adversely affect female fertility, and it is not recommended for women planning a pregnancy.

After 2 weeks of use, it is necessary to control the biochemical parameters of liver function.

Nise® tablets are contraindicated for children under 12 years of age, but if it is necessary to use nimesulide in children over 7 years old, Nise® 50 mg dispersible tablets and suspension can be used, in strict accordance with the instructions for medical use attached to them.

Due to the fact that the use of the drug may cause such side effects as dizziness, drowsiness and blurred vision, care should be taken when prescribing it to patients involved in potentially hazardous activities that require increased concentration and quick mental and motor reactions.

Storage conditions of the drug Nise

List B.: In a dry, dark place, at temperatures up to 25 ° C.

Shelf life of the drug Nise

Belonging of the drug Nise to the ATX classification:

M Musculoskeletal system

M02 Topical preparations for pain syndrome in diseases of the musculoskeletal system

M02A Topical preparations for pain in diseases of the musculoskeletal system

When any disease occurs, patients or their relatives are actively looking for exactly those drugs that can quickly and effectively cure the disease, stop the main symptoms or alleviate the patient's condition. In the event of inflammatory diseases, Nise is the right remedy.

"Nise" is a non-steroidal anti-inflammatory drug, the main action of which is aimed at inhibiting cyclooxygenase 2 and directly blocks the production of prostaglandins in the inflammatory focus.

This action is due to the fact that prostaglandins are enzymes that provoke an inflammatory process, they also have the ability to increase the sensitivity of nociceptive receptors, after which the pain becomes stronger and longer. And the enzymes of the cyclooxygenase group are activators of prostaglandins.

Release form

This drug has four active forms, while each has one active ingredient -. But they differ in the composition of excipients. Forms of the drug "Nise":

• Tablets - are issued in quantity No. 10 on one plate. Compound:
  • The main active ingredient nimesulide - a substance with anti-inflammatory action, blocks the activity and synthesis of urokinase, elastase, interleukin metalloprotease, collagenase, which helps to reduce the activity of destruction of cartilage tissue lesions in arthritis;
  • Auxiliary - calcium phosphate, silicon dioxide, magnesium stearate, corn starch, talc, microcrystalline cellulose, sodium glycolate, aspartame. These substances in the heap contribute to the manifestation of a slight adsorbing effect, improve the solubility and absorption of this drug in the acidic environment of the stomach;

• Dispersible tablets - dissolve in water before use, which improves the absorption of the drug in the gastrointestinal tract. The main composition of this option does not differ from conventional tablets;
• Suspension - this version of the drug, in addition to the main active ingredient, contains sorbitol, methylparaben, xanthan gum, sucrose, polysorbate 80, propylparaben. Most often it is prescribed for children because of the ease of use and sweet taste, the main feature of this variant of nise is a pronounced detoxification activity, in addition to the main anti-inflammatory and analgesic;
• Gel - the main substance remains nimesulide, and additional substances are represented by the following substances: propylene glycol, potassium phosphate, PEG-400, carbomer-940, N-methyl-2-pyrrolidone, timserosal, isopropanol, water, butylated hydroxyanisole. These components are aimed at improving the penetrating abilities of the drug, as well as better infiltration of the affected area.

Pharmacodynamics

Due to the activity of nimesulide (the main active substance), the drug has antipyretic, antiplatelet, analgesic, anti-inflammatory effects, inhibiting cyclooxygenase enzymes and other biologically active substances activated by it.

Due to the complete blockade of prostaglandins in addition to the site of inflammation, these drugs do not cause allergic reactions, blocking the release of mediators.

Another feature of Nise is expressed in the inhibition of phospholipid oxidation, which helps to strengthen the cell walls at the site of the inflammatory focus, also does not affect the cells of the immune system, and the antiplatelet effect does not affect hemostasis.

Pharmacokinetics

Thanks to auxiliary substances, one and a half hours after administration, the maximum content of the active substance in the blood is reached. If dispersible tablets are taken, the maximum concentration occurs even faster. The half-life of the drug does not exceed 3.5 hours. The active substance actively binds to blood plasma proteins, its formed elements, and is transported throughout the body.

This drug practically does not penetrate the blood-brain barrier. But its penetrating ability into other tissues is significantly pronounced. "Nise" has a penetrating ability through the hematosynovial barrier, which makes it possible to effectively relieve inflammation in the joint cavity, stop inflammation and pain in the tendons and peritendon synovial capsules.

The main substance is able to penetrate and accumulate in the mucous and submucosal tissues of the external female genital organs, in men the accumulation occurs near the bladder and at a short distance from it, along the urethra. This feature contributes to the effective treatment of serous inflammatory diseases of the genital organs and prostatitis.

Indications

Taking the drug is necessary in the presence of severe pain, inflammation, fever. "Nise" is taken for the combined treatment of the following diseases:

• Diseases of the joints and ligamentous apparatus - arthrosis, osteoarthritis, bursitis, bursovaginitis, tendinitis, rheumatism, myalgia, tendovaginitis. It can be used to relieve pain in case of bruises of the limbs, bone structures, spine;
• Infectious processes - it is necessary to take non-steroidal anti-inflammatory drugs to combat fever, inflammatory response and relief of the main manifestations of an acute infectious disease;
• Tuberculosis - taking nise is recommended to combat constant subfebrile condition, also with the development of exacerbations or activation of the process, it is taken against the background of antibiotic therapy;
• Inflammatory diseases of the genitourinary system - due to increased concentration in these areas, it becomes possible to quickly stop the pain syndrome and inflammatory reaction.

With the help of the gel "Nise" there is a local anesthetic effect in case of injury, sprain or tears of the bone-ligamentous apparatus, muscles. Blocking the action of prostaglandins, with local exposure, there is a decrease in the size of edema of the affected tissues, hyperemia is completely removed.

Local application of the gel allows you to stop all inflammatory manifestations in the affected areas.

Instructions for use

For adults, the allowed maximum daily dose is 450 mg, this dose is prescribed only by a doctor. This dose is resorted to in rare and difficult cases, with the ineffectiveness of other anti-inflammatory drugs. On average, for the relief of pain, inflammation, swelling, the doctor must prescribe "Nise" in 100 mg.

Children need to calculate the dosage of the drug in relation to kilograms of body weight. The optimal dose is 3-4 mg per kilogram of body weight. The drug is prohibited for children under the age of two years. Up to 12 years, the drug is prescribed in the form of a suspension or dispersing tablets, dissolving the necessary part of them in a teaspoon with water. After twelve years, the tablet form of the drug is allowed. Children weighing more than 40 kilograms can take "Nise" at adult dosages.

When applied topically, the gel must be applied to clean, washed skin. It is forbidden to apply the drug to areas of skin with damage.

When using the gel, it is necessary to ensure that it does not get into the eyes, on the wound or mucous membranes.

The maximum use of the drug of any form does not exceed 10 days. If before this period the disturbing symptoms do not subside, it is necessary to consult a doctor for additional help and a possible replacement of the drug.

Side effect

If you experience any suspicious reactions, discomfort behind the sternum or in the abdomen, deterioration of the general condition, the appearance of blood in my skin or yellowness of the skin, you should consult a doctor urgently. Perhaps this drug is not tolerated by the body properly, it needs to be replaced.

Taking "Nise" may appear manifestations of general intoxication, patients complain of:

• General weakness;
• Dizziness;
• Change in the nature of breathing;
• Drowsiness;
• Nausea, can reach up to vomiting, while antiemetic drugs do not stop the current situation;
• Chair change.

Since this drug is a cyclooxygenase inhibitor, there are frequent undesirable manifestations from the gastrointestinal tract. There is aching dull pain in the abdomen, most often in the epigastric region and the right hypochondrium. Perhaps yellowing of the sclera, biochemical analysis is characterized by high activity of transaminases.

Patients may notice a single vomiting, without initial manifestations of nausea, while the vomit is dark brown or light red, which indicates the opened ulcer bleeding and its duration. The appearance of dark mushy feces may indicate intestinal bleeding.

When applied topically, the side effects of the gel are:

1. Itching - during examination, scratching can be determined;
2. Redness is local;
3. puffiness;
4. Perhaps the manifestation of side effects, as in the use of tablet forms of the drug, when applied to large areas of the body. This phenomenon indicates a good absorption of the drug by the skin, and an increase in its concentration in the blood.

Since drowsiness and dizziness occur after administration, Nise must be taken with caution by drivers, the military and those people whose profession is associated with speed of response and attentiveness.

Contraindications

There are a number of contraindications to the use of this drug:

• Liver diseases characterized by the development of acute liver failure or leading to it;
• Ulcerative formations in the gastrointestinal tract;
• Type 2 diabetes;
• Hypertension;

You need to consult a doctor if you have acute heart failure, pregnancy or lactation.

Contraindications for external use are infectious skin diseases with damage to the outer epidermis, wounds of various etiologies.

There is a lot of controversy about the use of the drug in renal failure, since in the normal state of this organ, the use of nise does not affect the results of laboratory parameters, nor does it change the nature and amount of urine.

But since it is excreted only by the kidneys, it means that it increases the filtration load, which can lead to a deterioration in the patient's condition, with pre-developed renal failure.

Interaction

This drug has a significant competitive effect with drugs that stimulate cardiac contractility, lower blood pressure and other non-steroidal anti-inflammatory drugs.

This effect occurs due to the maximum binding of nimesulide to plasma proteins and most formed elements, which is a significant obstacle to other drugs. This phenomenon leads to an increase in the toxic effect of drugs or a decrease in their effectiveness.

It is forbidden to take nise with alcohol, drugs or other psychotropic substances. This combination increases the load and toxic effect on the liver and kidneys, which can lead to the development of acute organ failure, the development of toxic shock, coma. Such conditions often end in death.

Overdose

Neglecting the rules of taking the drug, taking large dosages, with the ineffectiveness of previous methods, one cannot do without the development of an overdose state. At first, dizziness, apathy, loss of consciousness or increased drowsiness may occur. At this stage, it is necessary to wash the stomach, drink plenty of fluids and induce vomiting.

Terrible conditions in case of overdose is the development of renal, hepatic, cardiovascular insufficiency. These conditions require urgent hospitalization and detoxification infusion therapy.

Most of humanity is often faced with such a problem as toothache, which can manifest itself due to thermal or mechanical action on some tooth tissues. More often, pain appears due to damage to hard areas of the teeth against the background of an inflammatory process in the soft nearby part surrounding the tooth, periosteum and the jaw itself, often with neuralgic pathology of the trigeminal nerve.

Quite often, soreness of the teeth manifests itself when a person has a malocclusion or during an exacerbation of certain diseases of the internal organs. Basically, severe toothache occurs when the tooth is damaged by caries, inflammation of the periodontium and pulp, or with periodontitis.

Causes of toothache

Will Nise save with toothaches

Judging by the reviews of the masses of people, it should be assumed that nise helps a lot with toothache. Nise tablets, when taken for toothache, are quite actively absorbed and quickly penetrate into the blood, therefore, the pain syndrome is relieved in a fairly short time. The drug can cope even with acute attacks of toothache, which occurs as a result of deep caries or pulpitis, while the duration of anesthesia lasts about 4 hours. But the most active nise from toothache helps with mild or moderate painful manifestations.

The tool has an anti-inflammatory effect, which can be directly at the time of taking nise during an attack of toothache. It is for these reasons that we can say that with an inflammatory process in the pulp, one should not expect a complete recovery and elimination of this disease. Nise can only temporarily block the pain and development of inflammation processes, but cannot affect the progression of the disease.

Advantages of the drug

During the period of toothache, it is important to ease it as soon as possible or completely eliminate it. Nise acts approximately 20-30 minutes after taking - a lot depends on the individual characteristics of the person, as well as the reasons that became the impetus for the onset of discomfort

There are several significant benefits of the drug:

How to use Nise tablets correctly

The method of administration is somewhat different for suspension and for tablets.

Tablets

Nise tablets are more often indicated for adults or adolescents who have a body weight of at least 40 kg. It is allowed to use 1 tablet 2-3 times a day. In the case of an early resumption of pain symptoms, the interval between doses can be reduced, but you should not drink more than 4 tablets per day, even with active acute pain.

Tablets are produced in the usual form and dispersible. The annotation for use states that dispersible tablets require prior dissolution in 1 tsp. ordinary water, and then use the resulting solution. It is recommended to use after meals. But ordinary tablets are simply washed down with the necessary amount of water and also after eating.

Suspension

The finished suspension is prescribed for children after 2 years and before reaching 12. The dosage is calculated based on the child's body weight (about 5 mg per 1 kg of weight), the resulting solution is divided into 2 doses. In general, the suspension is taken before meals, but in case of discomfort in the child, the reception is allowed to be postponed at the end of the meal.

The duration of taking the drug should not be more than 10 days. And during this period, you can already find time to visit a specialist.

Possible contraindications

This drug requires caution if you:

• Ulcerative diseases of the gastrointestinal tract;
• Bronchial asthma and the presence of polyps in the nasal cavity;
• Individual intolerance to the components that make up the drug (especially aspirin);
• Heart failure and diabetes.

It is important to remember that this remedy cannot be prescribed to babies under 2 years of age, as well as during pregnancy and lactation.

A complication can manifest itself in the form of an intestinal disorder, pain in the stomach, diarrhea, or an allergic reaction. Rarely, but protein may appear in the urine in a sufficiently large amount.

Important! The longer the course of admission drug Nise the more likely the appearance of 1 or more adverse symptoms. Therefore, you should not abuse the frequent intake of funds to prevent additional diseases. In case of acute manifestations of toothache, you should immediately go to the dentist to eliminate the cause of the pain.

www.nashizuby.ru

About the drug "Nise"

The active ingredient of the drug is nimesulide. As well as its analogue in terms of the active substance - "Nimesil", "Nise" is often used to relieve severe toothache. The drug is produced by the Indian company Dr. Reddy's in two forms: in the form of a suspension and tablets. The suspension is intended for children and is most often prescribed as an antipyretic, and tablets are allowed from the age of 12.

How does Nise work?

"Nise" belongs to the category of NSAIDs - non-steroidal anti-inflammatory drugs. Its peculiarity lies in the fact that it selectively blocks COX-II. What it is? COX stands for cyclooxygenase. It is an enzyme that is involved in the formation of prostaglandins. In turn, prostaglandins are substances that, in the event of pain in the body, increase its manifestation. COX has 2 forms:

• COX-I - an enzyme that protects the gastric mucosa;
• COX-II is an enzyme that causes inflammation.

The action of "Nise" is aimed at blocking COX-II, due to which the inflammation is removed. And due to the fact that the amount of COX-I remains unchanged, side effects from the stomach are minimized when taking the medication.

Does Nise help with toothache?

Reviews confirm that "Nise" is effective for toothache. Tablets are quickly absorbed and enter the bloodstream, so relief comes quickly enough. "Nise" is able to relieve even acute pain caused by deep caries and pulpitis, while the duration of the drug's action reaches 4 hours. But tablets are more effective in coping with mild to moderate pain.

When traveling and traveling, the toothbrush must be stored properly. Learn how to choose a toothbrush case.

Information about the types of prostheses can become relevant for everyone. You can read more about fixed dentures here.

The drug has an anti-inflammatory effect, but it is only at the time of use of the drug. Therefore, taking "Nise", say, with inflammation of the pulp, one should not expect that this will lead to recovery and eliminate the disease. The drug only blocks the pain syndrome and the inflammatory process, but does not affect the progression of the disease.

How to take "Nise" if your teeth hurt?

When taking Nise for toothache, first of all, you need to carefully study the instructions. Each tablet contains 100 mg of the active substance. According to the package insert, adults and children over 12 years of age can take 2 tablets daily. If the pain is very severe, you can increase the dose, but drinking more than 4 tablets per day is prohibited.

Tablets are recommended to be taken after meals with clean water. If you drink pills on an empty stomach, this can provoke irritation of the mucous membrane and then, in addition to toothache, you will also get stomach pain. Taking "Nise" for toothache should not last more than 10 days. During this time, you need to visit the dentist.

Possible adverse reactions

The drug may cause side effects. Unlike other painkillers, Nise has a lot of them. And, despite the fact that Nise helps with toothache, dentists rarely recommend this particular drug.

Side effects include:

• heartburn;
• diarrhea and abdominal pain;
• nausea and vomiting;
• headache;
• anemia;
• skin rash;
• fluid retention in the body.

The longer the drug is taken, the greater the likelihood of adverse reactions. If you decide to use "Nise" for toothache, in no case exceed the maximum allowable daily dose of the drug.

Important: if you notice any side effects when using the drug, you should stop taking Nise. In case of an overdose, it is necessary to wash the stomach and drink activated charcoal at the rate of 1 tablet of coal per 10 kg of body weight, that is, with a body weight of 60 kg, you need to drink 6 tablets.

Contraindications to taking "Nise"

It is forbidden to take pills if you have any contraindications from the list:

• ulcers of the stomach and intestines;
• gastrointestinal bleeding;
• "aspirin triad": nasal polyps, aspirin intolerance and asthma attacks;
• liver problems;
• kidney failure;
• the period of bearing a child;
• hypersensitivity to the active substance.

If there is a need to take "Nise" during lactation, you need to interrupt breastfeeding during the period of taking the medication. With caution, it is worth drinking pills for people suffering from high blood pressure, with an insulin-dependent type of diabetes mellitus and heart problems.

stopparodontoz.ru

"Grandfather's methods": harsh but reliable

Ancestors always knew what to put on a aching tooth! There are the simplest "grandfather", still post-war, "recipes": alcohol or propolis tincture(or a piece of the “bee venom” itself) onto a piece of cotton wool, firmly press it against the “hollow”, repeating the process as the “healing substance” evaporates. We must prepare for the fact that at first the pain will increase a little, to tears from the eyes, but then it will definitely subside: the nerve itself dies from such a “cool” treatment. In fact, this process is analogous to pulling out a tooth, only delayed in time: with alcohol or propolis burned out by the nerve, the tooth will soon simply fall out on its own. So if you are ready to shine with dentures, this treatment may be suitable.

Many do not believe in the experience of their own ancestors, preferring the developments of ancient oriental traditions, and believe that toothache can be relieved acupuncture. Do not expect a sharp result: massage the cavity between the thumb and forefinger "He-gu" it really reduces unbearable pain a little, but science still doesn’t know why: because it really calms the inflammatory process, or simply because it distracts the sufferer, who now needs to look for the “He-gu point” and engage in self-healing.

It is up to you to decide what is best for pain: the methods of harsh ancestors or special preparations developed by medical firms.

Medications for infections in the mouth, gums, or tooth

Over the past fifty years, hundreds of drugs have been added to such classic painkillers as Analgin or Ketanov. We will dwell on the merits of the best of them in more detail.

Novocaine

With toothache Novocain remains the leader among painkillers and anti-inflammatory drugs, because it not only destroys pain without destroying the tooth, but also has valuable pathogenic qualities: in the treatment of a symptom (pain, in this case), able to heal from the disease itself (inflammation).

In addition, scientists have found that this tool improves blood and good for the nervous system. Novocaine for pain in the gum or tooth can be used at home in two ways. Most quickly relieves discomfort pressed to the focus of pain, a tampon abundantly moistened with medicine. But you can remove the symptoms of inflammation and rinsing by pouring the ampoule into a cup of water (but this is a longer method).

Novocain always helps by blocking the nerve fibers of the inflamed zone themselves, the effect is reminiscent of “freezing” in sports injuries. Be careful: Novocaine is contraindicated in hypotension, incompatible with certain drugs. For example, with all based on sulfanilamide (Etazol or Sulfazin).

People often ask: is it possible to drink Novocain directly in ampoules? Usually the answer is yes. Let's add: if you are sure that you have a healthy heart, otherwise an arrhythmia may occur. But, actually, it doesn't make sense: it's a local anesthetic, not a general one. It must be applied exclusively pointwise. If the stomach hurts, then drinking Novocaine in ampoules from this misfortune is also dangerous without a medical examination: this is fraught with perforation of the ulcer, bleeding.

nise

The Indian remedy for toothache Nise is widely known. Created, like children's Nimesil, on the basis of a strong anti-inflammatory substance nimesulide. nise relieves the most acute toothache in no longer than three hours. The fashion for this remedy is now such that many consider the medicine a panacea. Dispersible (soluble) tablets are especially pleasant for patients.

But this is not entirely true: the same Novocain, with luck, can not only alleviate suffering, but also, if the inflammation has not gone far, “cure” the tooth, but Nise does not cure toothache, only “muffles” it. However, it creates such an analgesic effect that many people forget about the disease itself, which, although it does not “appear” in the form of pain signals, actually continues to progress.

If you are "addicted" to this drug, do not forget that with prolonged use it causes:

• dizziness and nausea,
• heartburn and rash.

Lidocaine

Lidocaine is a drug specially developed for dentistry, it can be bought in the form of a spray, ampoules with a two percent or ten percent solution, gel. The drug relieves pain quickly, but not for long. So, the effect of using gels and aerosols ends after 15-20 minutes, but if you bought ampoules and built a tampon on a diseased hollow, the anesthetic effect of lidocaine on a diseased tooth will be longer - more than an hour.

People who choose this drug, but do not know which is more effective - Lidocaine or Novocain - will have to make their own choice, taking into account the following factors:

• Lidocaine is more pleasant to use because of the various forms of release, it acts on the affected area faster than Novocain;
• Novocain (especially if you keep a swab with a solution in a disturbing place) gives a longer effect. In addition, he fights with the inflammation itself;
• Lidocaine has a number of contraindications, in no case should it be used in the same dosage as Novocain, it can cause headaches and even photophobia with general physical weakness.

When asked what is more effective, Lidocaine or Novocaine, it is most correct to answer this way: with a one-time and short-term use, Lidocaine is better, it even competes with Nise, but if you have not yet decided on the date of the visit to dentistry, Novocaine is more suitable for home anesthesia.

Novigan

The instructions for this analgesic do not indicate that Novigan can be used for toothache. But, if the pain is unbearable, the pharmacy is far away, and only this remedy is at hand, then a pill is taken orally an hour before meals (or directly on the tooth, which is unpleasant, but let it dissolve).

Novigan is especially good for toothache if the pain “shoots” into the “brain” (gives off in the temples, the back of the head), because this medicine is also an excellent strong antispasmodic. The drug, however, has a number of contraindications (categorically should not be taken by children, pregnant women), it irritates the stomach, so it is best to drink it with milk. If you have not consulted a doctor, Novigan can cause ulcers and intestinal bleeding, you should not take it for more than four days.

Nurofen

Nurofen - a remedy for toothache, this is one of the newest medications (based on ibuprofen). Available in a wide variety of forms (gels, tablets, suspensions and syrups with vitamin supplements) in a very modern and beautiful packaging. Nurofen for toothache is popular among sufferers, acts directly on the factors contributing to the inflammatory process("agents"). Therefore, Nurofen not only quickly helps with toothache, but also slows down the process of the disease itself. Use it, but under the condition of careful use, since it also has serious drawbacks.

Nurofen contraindications:

• asthma;
• diseases (bleeding, pain) of the gastrointestinal tract;
• impaired vision or hearing;
• liver or kidney disease.

Calgel for adults and children

The developed Kalgel toothpaste simultaneously anesthetizes and has a strong antimicrobial effect. Sold in tubes and cardboard packs. The paste can be applied to the inflamed area of ​​​​the gums directly with your finger (clean), but it is better with a medical spatula or a cotton swab. The effect comes quickly. There is only one contraindication: renal failure. You can apply the paste on the painful focus up to six times a day.

Unfortunately, Calgel gel paste is a rather expensive medicine. If you are looking for an inexpensive analogue of Calgel, it is better to buy Kamistad gel. When using it, there are almost no side effects. The best cheap analogues of Calgel for children are pastes based on the same lidocaine, vitamins and chamomile extract:

Dentinox - ointment is especially useful when teeth are cut in children. For very young children, it is better for mothers to choose those that do not contain Lidocaine:

• Dr. Baby - contains calendula, echinacea, marshmallow root extract, it helps a lot when the first teeth are cut;
• Mundizal - helps not only with diseases of the oral cavity, but also with infections in the spouts.

For acute pain in adults, it is better to go to the first-aid post and you will be given an anesthetic injection. : an injection or the same Lidocaine for local anesthesia or drugs such as analogs of Ketarol and Solpadein. But it is better not to bring your body to such acute attacks, it is preferable and easier to use any of the drugs listed above.

rodinkam.com

Nise - composition of the tablet

The active ingredient of the described medication is nimesulide in the amount of 100 mg per pill. This substance is a non-steroidal chemical compound from the group of sulfonanilides. It inhibits the production of enzymes that are involved in the synthesis of mediators of pain, swelling and inflammation. There are also auxiliary components added to Nise - the composition includes:

• calcium hydrophosphate;
• corn starch;
• microcrystalline cellulose type 114;
• sodium carboxymethyl starch;
• magnesium stearate;
• colloidal silicon dioxide;
• purified talc.

Nise tablets - what helps?

The considered pharmacological agent is prescribed only for symptomatic therapy; it does not affect the causes of the disease and its course. Tablets Nise - indications for use:

• toothache and headache;
• algomenorrhea;
• sciatica;
• pain in the postoperative period;
• arthralgia;
• bursitis;
• post-traumatic pain;
• inflammation of soft tissues, tendons and ligaments;
• myalgia of rheumatic and other origin;
• febrile syndrome;
• neuralgia.

Medical studies have shown that nimesulide not only eliminates pain, swelling and inflammation, but also prevents damage to cartilage tissue, stops the destruction of collagen. Thanks to this action, there are a number of musculoskeletal pathologies in which Nise is also effective, the indications for the use of which are as follows:

• articular syndrome during gouty exacerbations;
• rheumatoid and psoriatic arthritis;
• osteochondrosis;
• ankylosing spondylitis;
• radicular syndrome;
• osteoarthritis;
• tendovaginitis;
• ankylosing spondylitis;
• vertebral pain against the background of scoliosis and other diseases;
• osteoarthritis;
• tendinitis;
• radiculitis;
• pain in osteoporosis.

How to take Nise tablets?

The presented drug acts quickly and effectively, but it is important to follow the recommendations for its use. It is advisable to consult a doctor before drinking Nise - using the medicine in the wrong dosage can cause negative side effects. Additionally, it is necessary to clarify the duration of the therapeutic course.

The described medication is prescribed mainly to adults. Adolescents from 12 years of age with a body weight of 40 kg or more can take Nise tablets at a standard dosage of 100 mg. If the weight is less, the amount of nimesulide is calculated at 3-5 mg per 1 kg. Babies under 3 years of age, the drug in question is not prescribed. If the child has reached the specified age, it is allowed to use dispersible Nise - tablets for children that dissolve in water. They are available in a dosage of 50 mg of the active ingredient in each pill.

How to take Nise for toothache?

An anti-inflammatory agent based on nimesulide is used to relieve discomfort before and after dental procedures. In these situations, according to the classical scheme, Nise is prescribed - tablets for toothache are taken 2 times a day, 1 piece (100 mg). The maximum daily dosage is 200 mg. Experts advise drinking pills before meals, but if you experience discomfort in the stomach or intestines, it is better to use Nise tablets after a meal. The duration of the course is calculated individually, but should not exceed 15 days.

How to take Nise with osteochondrosis?

Back pain, inflammatory processes and edema also effectively stop nimesulide. With a recurrence of osteochondrosis, a standard method is prescribed, how to take Nise - 100 mg 2 times a day. Similarly, tablets are used for the symptomatic treatment of other musculoskeletal pathologies with pain. The duration of treatment is determined depending on the severity of clinical signs, mainly it is 7-12 days.

The presented pharmacological agent helps from the problem under consideration, but not always. Painkillers Nise are recommended only if the attack occurs against the background of:

• elevated body temperature;
• inflammatory processes, for example, meningitis;
• voltage;
• overwork;
• stress
• lack of sleep;
• changes in weather conditions;
• toothache;
• blows and bruises;
• surgical interventions;
• medical procedures;
• noise;
• jumps in blood pressure;
• osteochondrosis;
• infringement of the nerve roots and other factors.

Nise tablets are ineffective if the cause of pain is migraine. In this case, no anti-inflammatory nonsteroidal medicines will help. For migraine attacks, it is better to take drugs that have a direct effect on the dilated blood vessels in the brain and block the sensitivity of the trigeminal receptors. These drugs include triptans.

How long does the Nise tablet last?

The duration of the analgesic and anti-inflammatory effect depends on the nature of the discomfort, their intensity and cause. Nise 100 mg tablets block discomfort for 0.5 days. The degree of pain relief gradually decreases, because nimesulide begins to be excreted from the body after 2-5 hours. The maximum analgesic effect is observed 20-25 minutes after taking the pill.

How many times a day can Nise be taken?

The recommended frequency of use of the medication in question is limited to two times. In extremely rare situations, the doctor may allow you to drink Nise tablets more often - the use of an anti-inflammatory drug is allowed at a maximum daily dosage of 400 mg. Exceptional cases, when nimesulide is prescribed 4 times a day, occur in surgical practice. After some operations, the severity of the pain syndrome is too intense, and in order to avoid a state of shock, the analgesic will be used in an increased dose.

How long can Nise tablets be taken?

The duration of symptomatic therapy should correspond to the specific situation. Only a specialist decides how many days Nise can be taken. The maximum recommended duration of treatment is 15 days. More often, nimesulide is used until the swelling and signs of inflammation disappear - 7-10 days or less. For headaches, menstrual, toothaches, the medication is used for 2-3 days or once.

Can Nise be taken with alcohol?

There are no direct indications regarding the simultaneous use of nimesulide and the use of alcoholic beverages. Nise tablets help with headaches and fever against a hangover syndrome, quickly and effectively alleviating the condition. Doctors just do not recommend using the described drug in parallel with strong drinks and on the eve of parties. Nise and alcohol are poorly compatible, because ethanol is able to retain fluid in the body. Together with it, nimesulide accumulates in the digestive system, which can provoke dangerous consequences.

Nise tablets - side effects

The presented pharmacological agent is rarely accompanied by negative concomitant phenomena. Most tablets are well tolerated, less than 5% of patients cannot take Nise - side effects include:

• dizziness;
• nervousness;
• feeling of unreasonable fear;
• nightmares;
• drowsiness;
• swelling of the face;
• encephalopathy in the form of Reis syndrome;
• headache;
• Lyell's syndrome;
• immune hypersensitivity reactions;
• skin rash (urticaria, eczema, dermatitis);
• anaphylactic shock;
• increased sweating;
• multiform exudative erythema;
• angioedema;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis;
• dysuria;
• hyperkalemia;
• urinary retention;
• hematuria;
• kidney failure;
• interstitial nephritis;
• severe swelling of the extremities;
• oliguria;
• nausea;
• constipation;
• gastritis;
• flatulence;
• diarrhea;
• vomit;
• stomatitis;
• pain in the epigastric region;
• tarry soft stools;
• exacerbation of peptic ulcer, perforation of the stomach or duodenum 12;
• internal bleeding;
• hepatitis, including fulminant form;
• cholestasis;
• drug jaundice;
• increase in transaminases;
• eosinophilia;
• anemia;
• pancytopenia;
• an increase in the duration of bleeding;
• thrombocytopenia;
• purpura;
• exacerbation of asthma attacks;
• dyspnea;
• bronchospasm;
• arterial hypertension;
• hot flashes;
• tachycardia;
• blurred vision or deterioration in its clarity;
• hemorrhage;
• general weakness, decreased performance;
• a sharp decrease in body temperature.

People with certain medical conditions are at higher risk for these problems. In such situations, it is necessary to use Nise with extreme caution, side effects are more often observed in the following pathologies:

• dysfunction of the kidneys and bladder;
• eye diseases;
• high blood pressure;
• cardiovascular diseases;
• severe liver damage.

Nimesulide is able to enter into chemical reactions with other non-steroidal anti-inflammatory drugs, so the simultaneous use of Nise and similar analgesics can lead to unwanted side effects. It is not recommended to take medication during pregnancy planning. It has been established that the drug has a negative effect on female fertility.

Nise tablets - contraindications

• a combination of recurrent nasal polyposis, paranasal sinuses or bronchial asthma and intolerance to acetylsalicylic acid or other non-steroidal analgesics;
• hypersensitivity to nimesulide or auxiliary ingredients of the drug;
• cerebrovascular, active gastric, intestinal or other bleeding;
• Crohn's disease in the stage of relapse;
• nonspecific ulcerative colitis during an exacerbation;
• decompensated heart failure;
• erosive or ulcerative lesions of the mucous membrane of the duodenum, stomach;
• hemophilia and other pathologies that change blood clotting;
• any active liver disease, including failure;
• alcoholism;
• hyperkalemia;
• severe renal failure with creatinine clearance less than 30 ml / min;
• the period after coronary artery bypass grafting;
• hepatotoxic reactions when prescribing drugs with nimesulide in the composition;
• concurrent use of potentially hepatotoxic chemicals.

Nise analgesic tablets are not prescribed for physiological conditions not associated with diseases:

• pregnancy;
• breast-feeding;
• age up to 3 years.

Nise analogue in tablets

If the presented medication is not suitable, you can choose an identical remedy. Nise pain pills are easy to replace with the following drugs:

• Nimesin;
• Remesulide;
• Nimid;
• Ameolin;
• Toro-Sanovel;
• Nimesulide;
• Alit;
• Pansulide;
• Negan;
• Aponil;
• Nanogan;
• Oksigan;
• Nimegesic;
• Affida;
• Nimuspaz;
• Mesulide;
• Nimulid;
• Sigan.

Generics (similar effect, different active substance):

• Osteal;
• Artromax;
• Piascledin;
• Synmeton;
• ibuprofen;
• MiG-400;
• Citramon;
• Ketanov;
• Indomethacin;
• Diclofenac;
• Sulindak;
• Naproxen;
• Celecoxib.

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Composition and form of release

The drug is produced in the form of dispersible tablets, the active ingredient of which is nimesulide.

There are also auxiliary substances, which include microcrystalline cellulose, corn starch, calcium phosphate, sodium carboxymethyl starch, talc, aspartame, magnesium stearate, colloidal silicon dioxide, pineapple flavor.

pharmachologic effect

The agent is an NSAID, a selective inhibitor of the COX-2 enzyme, which is involved in the synthesis of mediators of inflammation, swelling and pain - prostaglandins. The tool exhibits analgesic, anti-inflammatory and antipyretic effect.

The drug to some extent also affects COX-1, without interfering with the formation of prostaglandin E2, which helps to reduce the number of side effects of the drug, inhibits platelet aggregation, release of histamine, reduces the degree of bronchospasm provoked by exposure to acetaldehyde and histamine.

When applied topically, Nise weakens until the pain at the site of application disappears completely.

Action

Means Nise in the form of dispersible tablets, it must be consumed at the end of a meal or after. Before use, the tablet is dissolved in a teaspoon of water.

Tablets can only be given to children who are already three years old. The recommended dose is 3-5 milligrams per kilogram of body weight up to three times a day. The maximum dose is five milligrams per kilogram of body per day in two to three doses. With a body weight of more than forty kilograms, one hundred milligrams are prescribed twice a day.

The duration of the drug should not exceed one and a half weeks.

Overdose

In case of accidental overdose, an increase in blood pressure, convulsions, impaired renal function, liver failure, irritation of the gastrointestinal tract, respiratory depression is possible.

In this case, gastric lavage, activated charcoal, symptomatic treatment are indicated. A specific antidote has not been developed, and hemodialysis and forced diuresis are ineffective.

Side effects

When using the drug, diarrhea, heartburn, pain in the stomach, nausea and vomiting, erosive and ulcerative lesions of the gastrointestinal tract, toxic hepatitis, increased activity of hepatic transaminases, dizziness, headache, leukopenia, thrombocytopenia, agranulocytosis, anemia, skin rash, bronchospasm, anaphylactic shock, prolonged bleeding time, fluid retention, hematuria.

Indications

Among the many diseases in which pain is felt, the remedy is also prescribed for toothache.

Contraindications

The agent is not prescribed for the aspirin triad, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase and bleeding from the gastrointestinal tract, severe renal failure, impaired liver function, pregnancy and lactation, individual intolerance to knimesulide and other components of the drug.

With caution, Nise is prescribed for heart failure, arterial hypertension, insulin-dependent diabetes mellitus (type 2), and visual impairment.