Application of Panangin for a week of each month. Functions of potassium in the human body. Use in children

In this article, you can read the instructions for use medicinal product Panangin. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of doctors of specialists on the use of Panangin in their practice. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Panangin's analogues, if available structural analogues. Use for the treatment of potassium and magnesium deficiency, heart failure and myocardial infarction in adults, children, as well as during pregnancy and lactation.

Panangin- a drug that affects metabolic processes. Source of potassium and magnesium ions.

Potassium and magnesium are intracellular cations that play a major role in the functioning of many enzymes, the interaction of macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects contractility myocardium. Low level potassium and/or magnesium ions internal environment capable of exerting a proarrhythmic effect, predisposing to the development arterial hypertension, atherosclerosis coronary arteries and the occurrence of metabolic changes in the myocardium.

One of the most important physiological functions potassium is to maintain the membrane potential of neurons, myocytes and other excitable structures of myocardial tissue. Imbalance between intra- and extracellular potassium content leads to a decrease in myocardial contractility, the occurrence of arrhythmia, tachycardia and increased toxicity of cardiac glycosides.

Magnesium is a cofactor in over 300 enzymatic reactions energy metabolism and protein synthesis and nucleic acids. Magnesium reduces the tension of contraction and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has an anti-ischemic effect on myocardial tissue. Decreased contractility of myocytes of smooth muscles of the walls of arterioles, incl. coronary leads to vasodilation and increased coronary blood flow.

The combination of potassium and magnesium ions in one preparation is justified by the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the content of both ions in the body. With simultaneous correction of the levels of these electrolytes, an additive effect is observed, in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting their positive inotropic effect.

Pharmacokinetics

When taken orally, the absorption of the drug is high. Excreted with urine.

Data on the pharmacokinetics of the drug in the form of a solution for intravenous administration are not provided.

Indications

• as part of complex therapy heart failure, myocardial infarction, disorders heart rate(mainly ventricular arrhythmias);
• to improve the tolerance of cardiac glycosides;
• replenishment of potassium and magnesium deficiency with a decrease in their content in diet(for tablets).

Release forms

Film-coated tablets.

Solution for intravenous administration(in ampoules for injection).

Instructions for use and dosage

For oral administration

Assign 1-2 tablets 3 times a day. Maximum daily dose- 3 tablets 3 times a day.

The drug should be used after meals, because. acidic environment the contents of the stomach reduces its effectiveness.

The doctor determines the duration of therapy and the need for repeated courses individually.

For intravenous administration

The drug is prescribed intravenously drip (in a dropper), in the form of a slow infusion. single dose- 1-2 ampoules, if necessary reintroduction after 4-6 hours

To prepare a solution for intravenous infusion, the contents of 1-2 amp. dissolved in 50-100 ml of 5% glucose solution.

Side effect

• paresthesia (due to hyperkalemia);
• hyporeflexia;
• convulsions (due to hypermagnesemia);
• AV block;
• paradoxical reaction (increase in the number of extrasystoles);
• decrease in blood pressure;
• redness of the skin of the face (due to hypermagnesemia);
• nausea, vomiting;
• diarrhea (including those caused by hyperkalemia);
• a feeling of discomfort or burning in the pancreas (in patients with anacid gastritis or cholecystitis);
• respiratory depression (due to hypermagnesemia);
• a feeling of heat (due to hypermagnesemia);
• with rapid intravenous administration, symptoms of hyperkalemia and / or hypermagnesemia may develop.

Contraindications

For oral and intravenous administration

• acute and chronic renal failure;
• oliguria, anuria;
• Addison's disease;
• AV blockade 2 and 3 degrees;
• cardiogenic shock (BP<90 мм рт.ст.);
• hyperkalemia;
• hypermagnesemia;
• hypersensitivity to the components of the drug.

For oral administration

• severe myasthenia gravis;
• AV blockade 1 degree;
• hemolysis;
• violation of amino acid metabolism;
• acute metabolic acidosis;
• body dehydration.

Use during pregnancy and lactation

There are no data on the negative effect of the drug in the form of a solution for intravenous administration during pregnancy and lactation (breastfeeding).

With caution, the drug should be used orally during pregnancy (especially in the 1st trimester) and during lactation (breastfeeding).

special instructions

The drug should be used with caution in patients with an increased risk of hyperkalemia. In this case, it is necessary to regularly monitor the level of potassium ions in the blood plasma.

Before taking the drug, the patient should consult a doctor.

With rapid intravenous administration of the drug, skin hyperemia may develop.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive a car and engage in activities that require increased concentration and speed of psychomotor reactions.

drug interaction

With simultaneous use with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs, the risk of developing hyperkalemia increases up to the appearance of arrhythmia and asystole. The use of potassium preparations in conjunction with GCS eliminates the hypokalemia caused by them. Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.

The drug enhances the negative dromo- and batmotropic effect of antiarrhythmic drugs.

Due to the presence of potassium ions in the preparation, when using Panangin with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, NSAIDs, hyperkalemia may develop (it is necessary to control the level of potassium in the blood plasma); with anticholinergics - a more pronounced decrease in intestinal motility; with cardiac glycosides - a decrease in their action.

Magnesium preparations reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system. When used with atracurium, dexamethonium, suxamethonium, it is possible to increase the neuromuscular blockade; with calcitriol - an increase in the level of magnesium in the blood plasma; with calcium preparations, a decrease in the action of magnesium ions is observed.

With the simultaneous use of Panangin with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases (the level of potassium in the plasma should be monitored).

Analogues of the drug Panangin

Structural analogues for the active substance:

• Asparkam;
• Asparkam-L;
• Asparkam-UBF;
• Asparkam-Farmak;
• Potassium and magnesium asparaginate Berlin-Chemie;
• Pamaton.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Read the official information about the drug Panangin, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and is not a substitute for medical advice.

Panangin is a source of magnesium and potassium ions. It is a drug that affects metabolic processes. Magnesium and potassium are intracellular cations that play a major role in the work of many enzymes, in the formation of bonds between intracellular structures and macromolecules, in the mechanisms of muscle contractility.

Composition and form of release

Release form of the drug:

• Tablets.
• Injection.

The composition of the drug in the form of tablets

The active ingredients of Panangin tablets are: potassium aspartate (K + = 36.2 mg) 158 mg, anhydrous magnesium aspartate (Mg ++ = 11.8 mg) 140 mg.

Excipients of Panangin: anhydrous colloidal silica, magnesium stearate, povidone, corn starch, titanium dioxide, potato starch, Eudragit E, macrogol 6000, talc.

Panangin - instructions for use in various dosage forms

Panangin: use in the form of tablets

Dosage for the use of Panangin for treatment

Instructions for use Panangin says that the dosage of the drug should be determined by the doctor in accordance with the patient's condition, his history and individual characteristics. In most cases, it is customary to prescribe 1-2 tablets three times a day for oral administration. In severe cases (for example, with intolerance to digitalis preparations, in violation of coronary circulation, etc.) - 3 tablets three times a day.

After a few weeks of treatment (if it is successful), the dosage of Panangin can be reduced to 1 tablet 2-3 times a day. The drug should be taken after eating, because the acidic environment of the stomach will adversely affect the effectiveness of the drug. The duration of the use of Panangin and the need to repeat therapy is determined by the attending physician.

The use of Panangin intravenously

Panangin's solution for intravenous administration has a greenish tint (in some cases it is completely colorless), without visible mechanical inclusions, transparent. The drug contains potassium and magnesium aspartate (452 ​​mg and 400 mg in one ampoule, respectively). Water (up to 10 ml) acts as an auxiliary substance.

The instructions for use Panangin notes that the drug can be administered intravenously. A slow infusion is used (20 drops per minute). If necessary, the drug is administered again after a few hours. To prepare a solution for intravenous administration, the contents of one or two ampoules are dissolved in 50-100 ml of a 5% dextrose solution. The drug can be used for complex therapy.

The use of Panangin for heart disease

The instructions for the use of Panangin say that in pharmacies the drug is dispensed by prescription, so its intake must be agreed with the attending physician. For any heart disease, the intake of this drug is fully regulated by specialists, depending on the current state of the patient, his medical history, stage of the disease and additional individual indicators. In the treatment of chronic heart disease, it is recommended to take the drug in the amount of 1-2 tablets three times a day. In exceptional cases and in the presence of appropriate indications, the daily dose can be increased to 6-9 tablets.

Panangin allows you to make the heart rate more stable. Magnesium contained in the preparation has a positive effect on the nutrition of the heart muscle, expanding the coronary vessels, ensures normal blood flow, improves blood flow, thereby reducing the risk of thrombosis. Panangin also lowers blood cholesterol, which is very important in chronic heart disease.

Indications for Panangin's use

Panangin's solution:

• Chronic heart diseases (post-infarction condition, heart failure, etc.);
• Heart rhythm disturbances. First of all, ventricular arrhythmias (as an additional remedy);
• Treatment with cardiac glycosides (as an additional remedy).

The instructions for use note that Panangin tablets are usually used only as an additional remedy for:

• chronic heart disease;
• Heart rhythm disorders;
• Treatment with cardiac glycosides;
• Replacement treatment for potassium / magnesium deficiency;
• With diseases of the gastrointestinal tract;
• After suffering seasonal colds;
• After significant physical exertion;
• With cramps (usually calf muscles).

Contraindications to the use of Panangin

The use of Panangin is not recommended for anuria, oliguria, impaired renal function, heart block of 1, 2, 3 degrees, increased concentrations of magnesium and potassium in the blood serum, with high sensitivity to the components of the drug, phenylketonuria, acute form of metabolic acidosis, severe myasthenia gravis, dehydration of the body , Addison's disease.

The drug should be used with caution in persons who have any problems with the kidneys. Taking into account the fact that Panangin has a lot of contraindications in the instructions for use, its intake should be fully agreed with the doctor.

Panangin: side effects

When taking tablets, the following side effects are possible:

• AV blockade, an increase in the number of extrasystoles (paradoxical reaction);
• Vomiting, nausea, diarrhea, discomfort and burning sensation in the pancreas (in the presence of cholecystitis or anacid gastritis);
• Hyperkalemia, hypermagnesemia, respiratory depression, hyporeflexia, decreased blood pressure, convulsions.

With intravenous use, in some cases, symptoms of hyperkalemia (paresthesia, fatigue, cardiac arrhythmia, arrhythmia, confusion) and hypermagnesemia (vomiting, decreased neuromuscular excitability, lethargy, vomiting, lowering blood pressure) may occur. Phlebitis, paradoxical reaction, AV-blockade sometimes develop.

How long can Panangin be used

Panangin is a source of potassium and magnesium, which are essential for the normal functioning of the heart and cardiovascular system. The instructions for the use of Panangin say that the systematic use of the drug can reduce the risk of developing a heart attack by several times, while reducing the risk of stroke by 40-50%.

If a person is interested in such results of treatment, then he is recommended to take Panangin permanently. In this case, you need to follow the maintenance dose, which is 1 tablet three times a day. At the same time, experts recommend using the drug in spring and autumn, for 2 months twice a year. This is due to the fact that in the spring months the human body experiences a deficiency of trace elements and vitamins, and in the fall it prepares for this deficiency.

The use of Panangin during pregnancy

According to the instructions for use, Panangin should be used with caution during pregnancy and breastfeeding (especially in the first trimester). If necessary, experts prescribe the use of this drug in the form of a solution intravenously during pregnancy and breastfeeding. There are no data on the negative effects of the drug in this case.

Panangin: application for children

Children and adolescents under the age of majority, the drug is prescribed in exceptional cases. Often, Panangin can be prescribed to newborns with acute failure of the pacemaker function and increased convulsive readiness. Allowed drip injection of 10 ml of the drug, which was diluted in 100 ml of 5% glucose solution. In the form of Panangin tablets, children can use 1/2-1 pills 2-3 times a day.

Therapeutic effects of Panangin

The extracellular and intracellular ratio of magnesium and potassium ions in the composition of Panangin affects the ability of the myocardium to contract. Endogenous aspartate acts as an ion conductor, has a high affinity for cells, due to the insignificant dissociation of its salts, ions penetrate into the cell as complex compounds. Magnesium and potassium aspartate improves myocardial metabolism. The lack of magnesium and / or potassium ions contributes to the development of arterial hypertension, the formation of metabolic compounds in the myocardium, and leads to atherosclerosis of the coronary arteries.

Potassium in the composition of Panangin supports the membrane potential of myocytes, neurons and other excitable structures of myocardial tissues. If the balance between extracellular and intracellular potassium content is disturbed, it can lead to a decrease in myocardial contractility, the development of tachycardia and arrhythmia, and an increase in the toxicity of cardiac glycosides. Magnesium in the composition of Panangin is one of the most important cofactors in more than 250 enzymatic reactions, including energy metabolism, the synthesis of nucleic acids and proteins. In addition, magnesium helps the cardiovascular system, improves heart rate and contractility, and leads to a decrease in myocardial demand for significant amounts of oxygen.

Compatibility of Panangin with alcohol

It is widely believed that Panangin allows you to cope well with withdrawal symptoms, but this is a complete misconception. At the same time, the drug is often used by narcologists for the combined treatment of alcohol dependence. The drug is prescribed to bring the patient out of binges with a severe and painful hangover, because at such moments the human body is under severe stress due to a lack of mineral components and dehydration.

In normal situations, it is strictly forbidden to use Panangin after drinking alcohol, because when the body is dehydrated, which usually happens after drinking alcohol, the blood in the vessels thickens, which leads to an increase in potassium levels. With an overdose of potassium in the human body, there is a serious danger to life, because this condition can lead to cardiac arrest. The use of Panangin in the treatment of alcohol dependence can only be authorized by an experienced and qualified specialist.

Panangin's analogs

Aspangin - an analogue of Panangin

A source of magnesium and calcium, allows you to restore electrolyte balance, contributes to the regulation of metabolic processes, gives an antiarrhythmic effect. Potassium is involved in the conduction of impulses along the nerve fibers and the implementation of muscle contractions. This analog allows you to maintain normal cardiac activity.

Analog - Asparkam

Source of magnesium and calcium. In the instructions for the use of Panangin, it is reported that the drug is necessary for the regulation of metabolic processes. The mechanism of action of Asparkam is due to the role of aspartate in the form of a carrier of potassium and magnesium ions into the space inside the cells. This analog allows you to get rid of the imbalance of electrolytes in the body, reduce the conductivity of the myocardium and its excitability.

Panangin's analogue - Pamaton

The drug is necessary to compensate for the deficiency of magnesium and potassium. The use of Panangin reduces the concentration of sodium, prevents its exchange in the smooth muscles of the vessels, reducing their resistance. The analogue of the drug has a stimulating effect on the synthesis of proteins, glycogen, ATP and other substances, supports the polarization of cell membranes.

Price for Panangin

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"Panangin" or "Asparkam": which is better, reviews, features and composition

Attacks of angina pectoris, the appearance of heart pain, arrhythmias can eventually lead to myocardial infarction. In order to avoid such a development of events, it is necessary to think about possible preventive measures that can, if not cure, then stop such a scenario.

The main cause of heart attacks is insufficient oxygen supply to the myocardium, caused by spasm of tissues and blood vessels. This leads to necrosis of the heart muscle. But with proper treatment, there is a chance to stop tissue necrosis.

As a rule, the complex therapy of cardiovascular diseases includes nitrates (for the relief of ischemic attacks), vasodilators, and vitamin preparations. Not the last place in this list is occupied by preparations of potassium and magnesium salts, "Asparkam" or "Panangin". What's better? And what's the difference?

Just what the doctor ordered

Feeling unwell, discomfort in the chest area, you should consult a doctor. These may not always be symptoms of more serious diseases, but it is worth making sure of this. Having made a cardiogram and not seeing any deviations, except, possibly, arrhythmia, the doctor can prescribe valerian tablets, as well as Panangin or Asparkam.

Cardiovascular drugs with more serious active substances are not always appropriate for such indications. And the patient’s logical question: “why should I do this?” Can lead the doctor into a stupor. After all, it is not customary to deny the need for prescribed therapy.

Please note: for the accuracy of treatment, it is necessary to donate blood for a detailed analysis. This is necessary to exclude a history of hyperkalemia and hypermagnesemia. With an excess of potassium and magnesium, treatment with salt preparations is not necessary.

The main indications for treatment with Asparkam and Panangin are the same, since both drugs contain 175 mg of potassium and magnesium aspartate. The exceptions are manufacturing companies: Panangin - Gedeon Richter (Hungary), and Asparkam is produced in many pharmaceutical factories of the former USSR.

Indications

Due to their composition, both drugs are the most popular in the pharmaceutical market. The main difference between Panangin and Asparkam is reviews and prices.

Medicines are prescribed:

• With a deficiency of potassium and magnesium salts.
• Atrial ventricular arrhythmias.
• A multipurpose method of treatment in people who have survived a heart attack.
• As an additional source of salts when taking digitalis preparations.
• A source of essential trace elements for poor or dietary nutrition.
• Source of potassium when taking diuretics.

Contraindications

If you are not satisfied with a consultation with a doctor, the full instructions for Asparkam and Panangin will help you understand when and who needs or is not allowed to take these drugs. If you carefully study the annotation, then there are still differences in contraindications. Their number is much greater in the domestic drug than in its foreign counterpart.

They have only five points in common:

1. Allergic reactions to the components of the drug.
2. Blood pressure below 90.
3. Insufficient nerve conduction in the muscles of the heart.
4. Addison's disease.
5. Kidney diseases associated with a malfunction in their work.

Although there are subparagraphs that are not in the instructions for the imported drug. "Asparkam" is contraindicated in:

• Insufficient urination.
• Complete absence of urination.

We drink, but be careful

The question of whether potassium and magnesium preparations can be used in patients with gastrointestinal ulcers has been repeatedly discussed. There is no definite answer, since Panangin is produced in a film shell, which gives it a significant advantage over other drugs. Although his instructions clearly indicate such points as careful use in patients with peptic ulcer and intestinal obstruction.

In addition, caution is also necessary when used in patients with acute dehydration due to vomiting or intestinal upset, burns of most of the body.

With caution, reception is also possible in people suffering from various autoimmune diseases associated with abnormalities in the functioning of the facial muscles (myasthenia gravis).

What to drink with?

Do not forget that taking even vitamins can affect the pharmacological properties of drugs. Therefore, you should be careful about what and with what to take.

Studies have been carried out and experts have voiced reviews about "Pananigin" or "Asparkam" - which is better not to take with them. A risk group with possible hyperkalemia in the future is people taking medicines for the treatment of hypertension with a potassium retention effect.

Diuretics of the new generation also tend to retain potassium in the tissues. In the case of their use together with potassium, an increase in the content of this element in the blood is inevitable. Non-steroidal anti-inflammatory drugs, heparin, antibiotics (Polymexin, Neomycin) are not an exception.

In addition, there is a possibility of poor absorption in the stomach of potassium and magnesium salts while taking tetracycline, iron preparations and sodium fluoride. Their use is possible only if one of the dosage forms is taken no earlier than three hours later.

The difference in the warnings for "Asparkam" and "Panangin" is incompatibility with drugs for anesthesia (the nervous system is inhibited) and muscle relaxants (muscle blockade increases). There is such a warning only for Asparkam.

Overdose

How scary the word "overdose" sounds! Involuntarily, terrible pictures come to mind about those who did not calculate the dose of a narcotic drug. But not everything is so sad. There should be no lethal outcomes with timely intervention.

1. The first and most common symptom: a violation of sensitivity in the nerve endings of the arms and legs, a slight tingling, "goosebumps" under the skin. They appear in the event that the limb was squeezed, clamped for a short time.
2. Second symptom: muscle weakness, slow heartbeat. Both symptoms are characteristic of an excess of potassium in the body, and if first aid is not provided in time, the patient may die from cardiac arrest.
3. The third symptom: drowsiness associated with a decrease in blood pressure.
4. The fourth symptom: vomiting, upset stomach and intestines, associated with an excess of magnesium in the body. In addition, there may be a feeling of a metallic taste in the mouth, thirst.
5. And the simplest, but no less important symptom is skin rashes, with reddening of the skin and increased itching.

How many tablets, who and when to take?

The standard dosage is to take one tablet three times a day, fifteen minutes after meals. The number of tablets per day can be increased to nine, if such treatment is prescribed by a doctor.

The duration of therapy also depends on the doctor.

Pregnant, lactating mothers, drivers and children

Special medical studies on the use of mineral salt preparations in pregnant and lactating women have not been conducted. But there are known cases of using "Asparkam" or "Panangin" by pregnant women. Reviews that it is better or worse tolerated have not been received. The main point is that there was no harm from taking breastfeeding women and expectant mothers.

But we must remember that "Asparkam" involves taking only when the benefit to the mother outweighs the risk to the fetus. And "Panangin" is not forbidden to use this category of consumers.

Since drugs do not affect the nervous system, general well-being and reaction rate, drivers are allowed to use them.

Due to the lack of clinical studies on the effect of potassium and magnesium aspartate on the body of children, the use of tablets in pediatric practice is strictly prohibited.

word of mouth

For many consumers, price and reviews play an important role in choosing a drug. Which is better, "Asparkam" or "Panangin", they decide after a heart-to-heart talk with a neighbor or after reading reviews.

Comparing their well-being while taking both drugs, patients noted one big minus of Asparkam: after taking the pill, the patient begins to fall asleep. Although, perhaps, this is one of the individual characteristics of this particular drug.

In general, both drugs are well tolerated, and the result is visible already at the end of the first week of administration. The main difference between these drugs is the price. "Asparkam" costs from thirty to seventy rubles, and "Panangin" - from one hundred and twenty to one hundred and seventy rubles.

What are the doctors talking about?

It is worth noting that experienced cardiologists insist on the correct prescription and use of drugs containing potassium and magnesium aspartate. After all, excessive passion can lead to an excess of potassium in the body, and with it unpleasant side effects.

When asked which is better "Asparkam" or "Panangin", the doctors' reviews are ambiguous. The first of the tips they give to their patients is to take blood for analysis and only then, if it shows a lack of potassium and magnesium salts, take action.

The second tip: the right dosage. Some Internet resources indicate that one tablet of "Panangin" or "Asparkam" is a sufficient dosage for the prevention of hypokalemia and hypomagnesemia. But if you calculate, then the same "Panangin" contains no more than 25 mg of pure potassium in one tablet, with a daily dosage of two grams.

Reading the reviews, which is better, Asparkam or Panangin, pay attention to how much both drugs were taken. Taking one tablet a day is akin to harmless ascorbic acid with sugar, unless, of course, you have diabetes.

Third advice: compatibility with other drugs prescribed for the treatment of arterial hypertension, arrhythmias, etc. ACE inhibitors, sartans, aldosterone antagonists contribute to potassium retention in the body. Together with long-term use of "Asparkam" and "Panangin" can lead to its overabundance in the body.

If you still have not decided what to use for treatment - Pananigin or Asparkam, instructions, reviews, prices and analogues of salt preparations are always at your service. Having carefully studied all the nuances, as well as the opinion of doctors, you can easily understand which of these drugs is more suitable.

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Panangin

Panangin is a combined preparation, a source of potassium and magnesium ions in an active, easily digestible form. Lack of potassium and magnesium in the body leads to heart failure and stroke. The main active ingredient of the drug is potassium and magnesium aspartate, which nourishes and strengthens the heart muscle, improves heart function, normalizes metabolic processes in the myocardium, which prevents the development of cardiovascular diseases, hypertension, atherosclerosis, arrhythmias, and also reduces blood viscosity, maintains the elasticity of blood vessels. vessels, preventing the formation of blood clots. Panangin is used for the treatment and prevention of cardiovascular diseases, it is available in the form of tablets and a solution for intravenous injection.

Panangin is used for the prevention and treatment of cardiovascular diseases, heart failure, cardiac arrhythmias, angina pectoris, arrhythmias, and during recovery from myocardial infarction.

Panangin in the form of tablets is taken orally, after meals. Usually prescribed 1-2 tablets 3 times a day, the duration of treatment is determined by the doctor. When preparing a solution for intravenous injection, dissolve the contents of 1-2 ampoules (10-20 ml) in 50-100 ml of 5% glucose. If necessary, the injection can be repeated after 4-6 hours. For prophylaxis, take one tablet 3 times a day, after meals, for 3-4 weeks, the prophylactic course can be repeated.

Panangin is produced in the form of round tablets of almost white color, film-coated, packaged in bottles of 50 pieces, one bottle in a cardboard bundle; and also in the form of a solution for intravenous infusion in ampoules of 1 ml, in a package of 5 ampoules.

Panangin is contraindicated in people with hypersensitivity to the components of the drug, with renal failure and hyperkalemia. Pregnant and lactating women use with great caution.

The composition of the drug Panangin includes the main active ingredients: potassium aspartate and magnesium aspartate, as well as excipients in tablets: povidone, silicon dioxide, magnesium stearate, talc, corn starch, potato starch; excipient in solution - water for injection.

Solution for injections, infusions, intravenous, intramuscular injectionsCardiovascular agents

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For heart health: Panangin for the prevention and treatment of diseases of the cardiovascular system

Minerals play a huge role in the human body. In case of their shortage, a person's condition can significantly worsen, and in the future, a disease, including hypertension, can form.

To avoid this, doctors very often prescribe Panangin, which restores the necessary amount of magnesium and potassium, and also supports heart health.

How to take Panangin? Instructions for use, at what pressure it is rational to use the drug and other nuances of its use in the article.

Panangin reduces pressure or not? The drug in its composition simultaneously contains potassium and magnesium ions. These two micronutrients are related, because in the case of a deficiency in the body of potassium, magnesium is usually also lacking. Therefore, most often, simultaneous correction of the level of these minerals, which are so necessary for the normal functioning of the body, is required.

Tablets Panangin

Potassium is needed to maintain the membrane potential of myocytes, neurons, and other cells of myocardial tissue. If there is a deficiency of this element, then there is a high probability of a violation of myocardial contractility, rhythm, sequence, frequency of contraction and excitation of the heart muscle.

Magnesium is involved in more than 300 enzymatic reactions. Muscle contraction, also cardiac, DNA and protein synthesis, nerve impulses - all these processes occur with the active participation of magnesium. This trace element has a positive effect on the heart muscle, reducing the likelihood of thrombosis, reducing the amount of accumulated cholesterol in the arteries. This action is provided due to the ability of magnesium to normalize the heart rhythm, nourish the heart muscle, and improve blood flow.

Panangin improves the functioning of the heart muscle, improves its work, strengthens, normalizes the metabolic processes occurring in the myocardium. In addition, the drug prevents the occurrence of atherosclerosis, arrhythmia, coronary heart disease, hypertension.

Indications for use

The therapeutic goals of Panangin are as follows:

• heart rhythm disturbances that arose due to intoxication with digitalis products;
• arrhythmia resulting from electrolyte disturbances;
• violations of the rhythm of the atria, ventricles of the heart;
• arterial hypertension;
• coronary insufficiency.

In addition, the concentration of potassium and magnesium should be replenished by athletes and people who have heavy physical exertion, lovers of saunas and baths, those who adhere to strict diets. Panangin for hypertension is also used for complex therapy in the case of taking diuretics, glucocorticoid hormones, sedatives, as well as for the treatment of diseases of the gastrointestinal tract.

Release form and composition

The release form of Panangin is of two types - injection and tablets.

There are two active ingredients in the preparation, namely:

• potassium aspartate, which in 1 ml of solution contains 45 mg, and in 1 tablet 158 ​​mg.
• magnesium aspartate, the volume of which in 1 ml of solution is 40 mg, and in 1 tablet 140 mg.

As for auxiliary agents, the following can be distinguished in the composition: povidone, magnesium stearate, potato, corn starch, talc, titanium dioxide, colloidal silicon dioxide, macrogol 6000, methacryric acid copolymer.

The tablets of the substance have a biconvex surface, their shape is round, the color is white. Packed tablets of 50 pieces in a plastic bottle. The solution for injection also contains water. It is colorless, transparent. It is in a 10 ml ampoule. Ampoules are placed in a cell package of 10 pieces.

Contraindications

Contraindications include some physiological and pathological conditions of the body, namely:

• Addison's disease;
• renal failure (chronic and acute);
• hypermagnesemia, hyperkalemia;
• severe myasthenia gravis;
• cardiogenic shock;
• atrioventricular blockade of 2-3 degrees;
• violation of amino acid metabolism;
• metabolic acidosis;
• hemolysis;
• hypersensitivity to components.

In addition, it is extremely careful to take the drug during pregnancy, regardless of the period, as well as during breastfeeding. It should not be used by people with adrenal insufficiency, persons under 18 years of age. Reception may be contraindicated in diseases of the liver and kidneys, atrioventricular blockade of the 1st degree. In continuation of the question of whether Panangin raises or lowers blood pressure, Panangin should not be taken at low pressure.

Although a heart drug is often prescribed for prevention, however, due to the presence of a large number of contraindications, you should consult a specialist before using it.

Side effects

Such a drug is well tolerated by the body. But the occurrence of side effects is not excluded.

In the case of an injection, side effects may be of the following nature:

• symptoms of hyperkalemia such as diarrhea, vomiting, paresthesia, nausea;
• symptoms of hypermagnesemia, namely: redness of the face, convulsions, thirst, decreased pressure, respiratory depression;
• paradoxical reaction;
• atrioventricular block;
• discomfort in the epigastric region.

If you quickly enter the solution for injection, then side effects of the following nature may also be observed:

• skin hyperemia;
• pressure drop;
• hyperkalemia and hypermagnesemia;
• phlebitis;
• paradoxical response.

Instructions for use

Since the answer to the question of whether Panangin reduces blood pressure, the answer is positive, as a rule, no more than 1-2 tablets per day are prescribed so as not to bring down blood pressure until you feel worse.

The maximum allowable daily dose is 9 pieces, which means that you can drink no more than three tablets at a time. The duration of treatment depends on the tests and is prescribed on the basis of them by the doctor.

The solution is used intravenously drip, using 1-2 ampoules at a time. To prepare it, you need to dissolve the contents of the ampoule in a 5% glucose solution with a volume of 50-100 ml. Re-introduction is allowed after 4-6 hours.

An acidic gastric environment can reduce the effectiveness of the drug, so it must be taken strictly after meals.

drug interaction

As already mentioned, the drug should be taken only after consulting a doctor.

At the same time, it is very important to inform him about other medicines that you use, since Panalgin can interact with them and harm the body.

When using iron salts and Tetracycline, sodium fluoride, this drug inhibits their absorption. In this regard, it is necessary to make an interval between doses of at least 3 hours.

Hyperkalemia may develop as a result of the simultaneous use of potassium-sparing diuretics or ACE inhibitors. Therefore, it is essential to monitor the concentration of potassium in the blood. Neuromuscular blockade can be triggered by the parallel use of Decamethonium, Suxamethonium, Atracuronium, Succinyl chloride. The concentration of magnesium is increased by taking Calcitriol.

Overdose

There were no cases of overdose with Panangin. If the recommended dose is exceeded, the manifestation of hyperkalemia and hypermagnesemia is likely. As treatment, symptomatic therapy is carried out.

To date, the shelves of pharmacies are filled with various medicines. And their range is growing rapidly. We can cure any disease that was fatal for our ancestors a couple of centuries ago with the help of pills, drops and ointments. But is everything as cloudless as it seems at first glance? Of course not. After all, almost every drug has a lot of side effects. When we treat one ailment, organs and even entire systems of our body's vital activity suffer. That is why we should treat even the most harmless medicine with extreme caution and take it only in case of emergency.

One of the clearest examples of such an effect on the human body is the medicine "Panangin". And before you find out how harmful this drug, which many people have in their home medicine cabinet, should be considered in more detail.

Clinical and pharmacological group

The drug "Panangin" is a representative of a group of drugs that restore magnesium and potassium deficiency in the body. It is most often used as a component of complex therapy for cardiac arrhythmias, myocardial infarction and heart failure. With a decrease in the content of magnesium and potassium in the diet, Panangin tablets are prescribed. Instructions for use of this medication clearly regulates the use of forms of the drug depending on the disease.

pharmachologic effect

As you know, magnesium and potassium are intracellular cations, which play a major role in the work of many enzymes, as well as the functioning of muscle contractility and strengthening bonds between intracellular structures and macromolecules. Extra- and intracellular ions of these elements contribute to the improvement of myocardial contractility. As for the endogenous aspartate contained in the preparation, it acts as an ion conductor and improves the metabolism of the heart muscle. Deficiency of potassium and magnesium in the body predisposes to the occurrence of atherosclerosis of the coronary vessels, arterial hypertension and disruption of metabolic processes in the myocardium.

Forms of release and packaging of medicines

To date, one of two forms of the drug "Panangin" can be purchased at the pharmacy: tablets or solution for intravenous administration. The first are sold in polypropylene bottles of 50 pieces. Biconvex round tablets are coated with a white film shell and have a slightly shiny, uneven surface.

The drug in the form of a clear solution without mechanical impurities is available in 10 ml glass ampoules.

The composition of the medicine

The drug "Panangin" contains two main active ingredients: potassium and magnesium asparaginates. Moreover, the first is used in the form of hemihydrate, the second - tetrahydrate. As excipients for tablets, povidone, corn and potato starch, talc, as well as colloidal silicon dioxide and magnesium stearate are used. As for the film shell of the tablets, it consists of talc, macrogol 600, titanium dioxide (E171) and a methacrylic acid copolymer.

The drug solution also contains two active ingredients and water. There are no other auxiliary components in this form of the drug.

Functions of potassium in the human body

One of the most important physiological processes in which the substance is involved is the maintenance of the membrane potential of myocytes, neurons and other excitable tissues of the heart muscle. The slightest imbalance of intra- and extracellular potassium content is the cause of arrhythmia, a decrease in myocardial contractility, tachycardia, etc.

However, it is worth remembering that, like other medications, the medicine "Panangin" has side effects. Therefore, before you start taking, you should always consult with a specialist.

Why is magnesium useful?

It is impossible to clearly answer the question of what is the main task of this substance in the functioning of the vital systems of the body. After all, potassium is one of the most important cofactors in more than 310 enzymatic reactions, such as the synthesis of nucleic acids and proteins, as well as energy metabolism.

Magnesium also has a positive effect on the cardiovascular system: it reduces the contractility of myocytes of smooth muscle tissue of arterioles. This effect leads to the normalization of coronary blood flow and vasodilation. As a result, heart rate improves and myocardial oxygen demand decreases. In other words, magnesium has an anti-ischemic effect on the tissues of the heart muscle.

Who is prescribed the drug?

For those who do not know what the Panangin tablets are from, it is worth saying that they are prescribed to compensate for the deficiency of magnesium and potassium, provided they are low in the diet.

Less often, the tablet form of the drug can be recommended for patients as part of the complex treatment of arrhythmia, heart failure and acute myocardial infarction. In most cases, people with such diseases are prescribed the drug "Panangin" in the form of a solution for intravenous administration.

Assign a solution or tablets "Panangin" (the instruction also contains this information) to people suffering from various heart diseases. This is due to the fact that potassium and magnesium ions improve the tolerability of cardiac glycosides.

Doses and method of administration of tablets

The doctor who prescribes the drug should tell the patient how to take Panangin. But, unfortunately, not all doctors perform their work efficiently and conscientiously. In this case, the patient should carefully read the information about the drug and only then take the medicine "Panangin". Instructions, reviews will help a lot in this.

Assign the drug for 1-2 tab. 3-4 times a day, but you should know that the maximum daily dose should not exceed 9 tablets. It is better to take the medicine a couple of minutes after eating, since the acidic environment of the stomach can significantly reduce its effectiveness. As for the duration of therapy and repeated courses of treatment, they should be determined only by the doctor, taking into account the individuality of each patient. Otherwise, if the patient takes Panangin without a doctor's prescription, side effects can be very serious.

Preparation and application of the solution

If the drug is prescribed to the patient by drip, the rate of administration should not exceed 20 drops per minute. In especially severe cases, repeated administration is possible after 5-6 hours. But such therapy is possible only under the supervision of doctors in a hospital setting.

To prepare a solution for intravenous infusion, the contents of 1-2 ampoules are dissolved in 50-100 ml of glucose. The ratio of the solvent and the dose of the drug is selected individually by the doctor.

Overdose and first aid

If the patient does not know how to take Panangin and does not bother to read the instructions, the consequences of such treatment in the form of hyperkalemia and hypermagnesemia will not take long. That is, within a short time after taking excessively high doses of the drug, the patient may experience symptoms such as myasthenia gravis, fatigue, confusion, paresthesia. With an overdose of potassium, the risk of cardiac arrhythmias increases several times, which can manifest itself in the form of arrhythmia, bradycardia, and even cardiac arrest.

If you exceed the permissible dose of the drug and do not know what side effects the Panangin drug has, the clinical picture of an overdose of potassium may be supplemented by symptoms of hypermagnesemia. In this case, the patient shows a decrease in muscle excitability and blood pressure, vomiting. If the magnesium content increased sharply, that is, a person exceeded a single dose of the drug by 2-3 times, there is a high probability of developing respiratory paralysis, inhibition of tendon reflexes and even coma.

Regardless of the reason for the overdose, how much the permissible dose was exceeded, the patient must immediately receive first aid. For this, a calcium chloride solution of 100 mg / min should be injected intravenously. In especially difficult cases of overdose, peritoneal dialysis and hemodialysis are indicated.

drug interaction

Even those who know what the Panangin tablets are from are interested in information about which medications it can be taken in combination with.

Simultaneous use of the drug with beta-blockers, potassium-sparing diuretics, heparin, ACE inhibitors, cyclosporine can cause the development of hyperkalemia. And, as you know, this can lead to the appearance of asystole and arrhythmia.

It is also worth noting that preparations containing calcium significantly reduce the effect of magnesium.

Has a remedy "Panangin" and contraindications to the simultaneous use with dexamethasone, atracurium and suxamethonium, as the risk of increased neuromuscular blockade increases.

As for enveloping and astringent agents, it is worth knowing that they slow down the absorption of the active ingredients of the drug in the gastrointestinal tract. Therefore, if there is a need for the compatibility of these drugs, the 3-hour interval should be strictly observed.

But at the same time, it is not only possible to use cardiac glycosides, but it is also recommended with the Panangin solution. The compatibility of these drugs is due to the fact that potassium and magnesium enhance the effect of drugs of the glycosidic structure and reduce their undesirable effect.

Contraindications

Like any other drug, Panangin is a medicine that has its own list of contraindications.

The tablet form of the drug is strictly forbidden to be taken by people suffering from chronic and acute renal failure, as this can aggravate the course of the disease and lead to serious consequences. Has a remedy "Panangin" contraindications for patients with hyperkalemia and hypermagnesemia, as well as severe myasthenia gravis.

The reason for refusing to use the drug can be a violation of amino acid metabolism, dehydration, acute metabolic acidosis, hemolysis and Addison's disease.

The solution "Panangin" contraindications are much wider. In addition to the above, include dehydration, lactation, pregnancy, age up to 18 years. Moreover, it is forbidden to use this form of the drug for people with insufficiency of the adrenal cortex.

Side effects of "Panangin"

It is almost impossible to predict the body's reaction to any of the components of the drug, so the instructions contain a list of all possible manifestations.

So, the digestive system can react to Panangin tablets with nausea, diarrhea, vomiting, discomfort in the pancreas.

On the part of the water and electrolyte balance, the development of hyperkalemia and hypermagnesemia is possible, which are accompanied by paresthesia, thirst, hyporeflexia, convulsions, decreased blood pressure and depression of the respiratory center.

If you quickly in / in the solution "Panangin", side effects, in addition to hyperkalemia and hypermagnesemia, may be supplemented by phlebitis, AV blockade and a paradoxical reaction.

Terms and conditions of storage

Since the drug "Panangin" is quite dangerous, it should be stored out of the reach of children at a temperature of 15 to 30 ° C. As for the expiration date, it is indicated on the packages of the medicine: for a solution - 3 years, and for tablets - 5 years.

The health of the body, work, "interaction" of organs depend on many factors. The most important is the balance of trace elements and minerals. Magnesium and potassium take an active part in the "debugging" of the activity of blood vessels, the heart. By promoting myocardial metabolism, improving the metabolic processes of the heart, they protect a person from heart attacks, arrhythmias, tachycardia and other diseases. The body receives these substances from the outside - with food or as a result of taking special preparations: asparkam or panangin. What is good about the latter, what are the indications for Panangin medicine?

Composition and form of release

It is a drug designed to compensate for the deficiency of magnesium, potassium in the body. Consists of two active substances:

• potassium aspartate - about 160 mg;
• magnesium aspartate - 140 mg.

Pharmaceutical companies produce:

• Tablets.
• Solution for intravenous administration.

Panangin for oral use is sold in a carton. 50 tablets, for protection from sunlight, are placed in one tight polypropylene (plastic) bottle. Glass ampoules containing the drug solution are sorted by 5 pcs. on a pallet. The package of liquid panangin includes 5 ampoules of 10 ml each..

Panangin - what does the medicine help with?

What is the mechanism of action of Panangin when the patient has indications for the use of the drug? Trace elements necessary for the normal functioning of the cardiovascular system perform the following functions:

1. Stimulate the work of the myocardium, increasing cardiac conduction of impulses.
2. Strengthen the walls of blood vessels, reducing muscle tone, increasing blood flow.
3. Normalize heart rhythm.
4. Participate in the metabolic processes of the heart, relieve swelling, spasms of internal organs.

For preventive purposes, cardiologists prescribe Panangin for patients:

• with the threat of ischemia;
• after a heart attack;
• people suffering from pain in the heart, swelling;
• with heart failure, arrhythmias;
• high blood pressure, hypertension.

Indications for the use of panangin are constant spasms, pain in the muscles of the legs. The lack of active substances leads to a "clamped" state of the muscular system and a constant contraction. Intense physical activity, mental work, stressful situations are prerequisites for a deficiency of potassium and magnesium. Taking the medicine in these cases increases efficiency, enhances stress resistance.

The entry of Mg and K into the composition of the drug is due to the simultaneous deficiency of these trace elements in the body. Potassium and magnesium ions in the complex create additive synergism, when each substance exhibits an effect separately, enhancing the action of the "companion". Indications for the use of the drug is to reduce the toxicity of cardiac glycosides, without affecting the positive effect.

Instructions for use of the drug

Tablet (capsule) form has a high absorption, excreted from the body with urine. In some cases, doctors determine the indications for the simultaneous use of cardiac glycosides and panangin. An increased load on the kidneys becomes a contraindication for diseases of the latter. The pharmacokinetics of intravenous injection is unknown.

Tablets

Panangin is taken after meals. Increased acidity of the stomach reduces the absorption of active substances, slowing down the effectiveness of the impact. The duration of treatment, the need for re-admission is determined by the doctor. Indications for use are as follows:

• General cases - 1 - 2 capsules 3 times throughout the day at regular intervals.
• In case of impaired coronary circulation, immunity to digitalis preparations, intolerance - 3 capsules three times a day after meals. Gradually, under the supervision of a doctor, the dosage is reduced.

Injection

Acute cases are an indication for the use of the liquid form of panangin. 10 ml solution for injection is diluted with 20-40 ml of isotonic sodium chloride or 5% glucose. The drug is administered by injection very slowly and gradually, so as not to cause signs of hyperkalemia, hypermagnesemia: nausea, gag reflexes, dizziness.

For patients with hypersensitivity to potassium, magnesium, doctors prescribe droppers. Two ampoules of the drug are diluted with 0.3 - 0.5 liters of saline (0.9% NaCl aqueous solution) or a five percent dextrose solution. Then they are administered to the patient drip. Time interval between injections: 4 - 6 hours. It is possible to use the drug as a component of complex therapy.

Contraindications to the use of the drug

The absence of indications for the appointment, the use of panangin are:

• Heart failure (acute).
• Chronic kidney disease, acute insufficiency.
• Intolerance to the components of the drug.
• Alcoholism.
• Confusion, fatigue, myasthenia gravis, parasthesia are signs of hyperkalemia.
• Dehydration.
• Stably low blood pressure, cases of cardiogenic shock.
• Low muscle excitability, difficulty breathing, dizziness, nausea are symptoms of hypermagnesemia.

Caution, only under the supervision of a doctor, Panangin is prescribed to patients with pathology of the conduction of the heart muscle. A burning sensation, discomfort in the epidural region is the reason to reduce the dosage of the medicine. Panangin is not recommended for use for women in the first trimester of pregnancy when breastfeeding.

Drug interactions and overdose

Overdose has not been clinically recorded. The theoretical consequences are the appearance and intensification of symptoms of oversaturation of the body with magnesium and potassium: nausea, constipation or diarrhea, muscle cramps, lethargy, dehydration. Such cases require:

1. Refusal to apply.
2. The introduction of saline (300 ml).
3. Particularly severe intoxication - hemodialysis.

In the complex treatment of several drugs, it is necessary to take into account the features of their interaction:

• Adrenoblockers, diuretics spironolactone and triamterene, cyclosparine, heparin, inhibitors and non-steroidal anti-inflammatory drugs - cause an excess of K, Mg in the body with inherent symptoms.
• Panangin reduces the effect of streptomycin, tetracycline, neomycin.
• Calcium-containing drugs dramatically reduce the effect of the use of magic.
• Anesthetics - together with Mg suppress the nervous excitability of the central nervous system.
• A positive effect of the use of panangin for indications is the compatibility of the solution and cardiac glycosides, the side effects of which are leveled.

Approximate cost of Panangin in tablets and ampoules

It is possible to buy panangin in ordinary and online pharmacies in Russia. The price of the drug varies by region of the country. So, if you want to buy a drug in Moscow, the cost will be from 120 to 155 rubles. for tablets and about 160 - 165 rubles for a solution for intravenous administration. The average price of panangin is about 130 - 140 rubles. in the form of capsules and 160 - 166 rubles for a pack of ampoules.

Panangin's analogues

What is the difference between panangin and asparkam, aspangin - domestic analogues? Panangin is an original drug, more purified. Asparkam is an analogue (copy) of this medicine. Coated tablets of the drug protect the gastrointestinal tract from negative effects, so people suffering from colitis, ulcers and gastritis should give preference to it.

The price indications of the drugs also differ: being a copy, asparkam and aspangin are two to three times cheaper than the original. Most people with indications for the use of drugs that compensate for the deficiency of K, Mg prefer panangin due to a noticeable effect on the heart muscle, leg muscles, and a decrease in the manifestations of varicose veins.

Instructions for use Panangin says that the drug is intended to restore the deficiency of potassium and magnesium, to improve the activity of the cardiovascular system in a particular pathology.

Description of the drug

The medicine Panangin is produced in two dosage forms. Tablets are round, biconvex, film-coated, white or grayish color, odorless. The preparation of this form of release is intended for oral administration. Tablets of 50 pieces are produced in jars or blisters placed in cardboard packaging.

Solution for injection is available in ampoules, has a white or slightly greenish tint, transparent, without visible chemical and mechanical additives. The solution is packed in 5 ampoules in a cardboard box, one ampoule - 10 ml.

International name (INN) Potassium aspartate + Magnesium aspartate.

Pharmacological group - a medicine that replenishes the deficiency of magnesium and potassium in the body.

Compound

The composition of Panangin includes potassium aspartate (tablet - 158 mg, ampoule - 45 mg), magnesium aspartate (tablet - 140 mg, ampoule - 40 mg) and auxiliary components.

The action of the drug

The drug Panangin is used in medical practice as a source of magnesium and potassium ions, serves as a catalyst for the metabolic processes of the body.

Potassium is necessary for a person for the normal functioning of myocardial fibers and the conduction system of the heart. With a deficiency of this component, the generation and conduction of impulses slows down, which negatively affects the activity of the heart muscle.

Magnesium takes part in the formation of more than three hundred enzymatic cellular systems. They play an important role in the formation of organic compounds, providing the body with energy.

Pharmacokinetics

After oral administration of the drug or using it as an injection, Panangin is rapidly absorbed and enters the bloodstream. To date, there is no exact information on the rate of absorption of potassium and magnesium by the body. The drug is excreted by the kidneys.

The drug is rapidly absorbed, providing a therapeutic effect.

Indications for use

In what area is the medicine used and what does Panangin help with? Use a remedy for the treatment of diseases of the heart and blood vessels due to a lack of potassium and magnesium ions.

Indications for Panangin's use:

• complex treatment of pathologies of the cardiovascular system;
• period of acute course of myocardial infarction;
• hypertensive heart disease;
• in the presence of pathological conduction pathways of the heart located in the ventricles;
• in the role of treatment of arrhythmias provoked by the intake of cardiac glycosides and some other medicines.

Medication dosage

Assign the described drug to patients after diagnosis. Consider how to take Panangin in various forms of release.

Tablets

Many patients are interested in how best to take Panangin - before or after meals? Experts recommend taking the tablets after meals with plenty of water.

injections

In the form of injections, the agent is administered through a dropper, very slowly (no more than 20 drops per minute), the procedure is performed exclusively by a medical professional. To prepare the solution, combine 20 ml of the product and 100 ml of glucose 5%. Repeated injection is administered if necessary after 5-6 hours.

Tablets and injections are used as an auxiliary or independent therapy for various heart diseases. Self-administration of the drug is extremely dangerous for health. The doctor must prescribe the remedy.

Panangin solution is used for setting droppers

Contraindications

Panangin and instructions for use for it states that there are contraindications for both tablets and injections.

Contraindications for oral administration:

• acute or chronic kidney failure;
• excess potassium or magnesium in the body;
• chronic adrenal insufficiency;
• atrioventricular blockades of 1-3 degrees;
• violation of metabolism in the body of amino acids;
• myasthenia gravis with severe course;
• conditions accompanied by dehydration of the body;
• acidosis.

With bradycardia, the drug is prescribed with extreme caution. When diagnosing a decrease in the frequency of heart beats, the use of the drug is prohibited.

Contraindications to the use of injections, in addition to those described above, are as follows:

• the patient's age is up to 18 years;
• pregnancy;
• period of breastfeeding;
• individual intolerance to the active and auxiliary components of the drug.

Side effects

If the dosage is violated, there are malfunctions in the functioning of the digestive system, epigastric pain, stool changes, stomach bleeding, nausea, dry mouth.

For the heart, Panangin can also cause side effects. Some patients are diagnosed with a decrease in blood pressure, heart rhythm disturbance, atrioventricular blockade.

From the side of the central nervous system, convulsions, paresthesias, impaired reflexes are noted. You can read more about the side effects and contraindications of the drug here.

Abdominal pain is one of the side effects of Panangin

Less often there is difficulty in breathing, fainting, changes in cardiogram parameters, cardiac arrest. With the development of a severe overdose, it is necessary to urgently deliver the patient to a hospital where resuscitation therapy is carried out with the introduction of dextrose or sodium chloride. In severe cases, hemodialysis is necessary.

Panangin during pregnancy

Is it possible to use the described drug during the period of bearing a baby and breastfeeding? There is no direct prohibition to prescribe the drug. The negative effect of potassium and magnesium on the child has not been confirmed. Despite this, the use of the drug during pregnancy should be done with caution, especially in the first 4 weeks.

Appointment in pediatrics

Panangin is prescribed to children only if there are serious indications for the use of the drug, mainly in the form of an injection. To set up a dropper, 10 ml of the product is diluted with 100 ml of glucose (5%).

When using tablets, the dosage of the drug is selected by the attending physician, depending on the weight and age of the patient.

Important! According to medical statistics, the use of the drug among newborns contributes to the closure of some congenital heart defects.

Panangin or Cardiomagnyl

Many patients are interested in what is better - Panangin or Cardiomagnyl, and is it possible to combine these two drugs? Taking Panangin and Cardiomagnyl together is not recommended, because both drugs have a similar composition. Medicines include magnesium, so taking them at the same time can cause an excess of it in the body. To select the appropriate remedy for a particular patient, you should contact a specialist, undergo an examination.

Drug compatibility

It is undesirable to simultaneously use the described drug with heparin drugs, angiotensin-converting enzyme inhibitors, NSAIDs, potassium-sparing diuretics, cyclosporine.

It is not recommended to simultaneously use Panangin with heparin, ACE inhibitors, non-steroidal anti-inflammatory drugs, potassium-sparing diuretics, cyclosporine and some other drugs, as this causes the risk of developing an excess of magnesium and potassium ions in the body.

It is important to consider the interaction of Panangin with other drugs

Magnesium in the composition of the product reduces the effect of Streptomycin, tetracycline drugs, Polymyxin B and Neomycin.

When Panangin is combined with anesthetics, their negative effect on the human nervous system is enhanced.

Alcohol compatibility

The compatibility of Panangin and alcohol is highly undesirable. Alcohol in itself has a negative effect on the body, and in combination with medicines can cause serious consequences. In this case, the following complications are noted:

• spasm of arteries and veins;
• impaired respiratory function;
• acute deficiency of potassium and magnesium electrolytes.

Some patients go into cardiac arrest. Given such consequences, in no case should Panangin and alcohol be combined.

Means analogues

In the reference book of drugs for radar, you can find the following analogues of Panangin:

• Plus vitamin B6 Panangin - a drug used as a dietary supplement with a lack of potassium, magnesium, vitamin B in the body;
• Aspirin Cardio - is used for the treatment and prevention of coronary heart disease, angina pectoris, in the period after heart surgery, after myocardial infarction;
• Riboxin is a complex remedy that is prescribed to patients for the treatment of coronary artery disease, heart defects, arrhythmias of various origins, atherosclerosis and other heart diseases. The composition of Riboxin includes inosine, which has a positive effect on the functioning of the heart muscle, promotes the establishment of metabolic processes, causes the necessary relaxation of the heart, and normalizes the frequency of contractions of the organ;
• Neocardil - has such indications as neurocirculatory dystonia, coronary heart disease, arterial hypertension, arrhythmias, angina pectoris and other diseases of the cardiovascular system.

It is strictly not recommended to take drugs that are similar in composition and action at the same time, it is allowed to do this only as directed by a doctor.

Terms of storage and sale

Panangin in the form of a solution is released from a pharmacy by prescription. Tablets are allowed as an over-the-counter remedy. Store the drug in a cool room at a temperature not exceeding 25 degrees.

Store the product according to the instructions for use

What the experts say

Stanislav Nikolaevich, cardiologist:

“Many patients believe that Panangin is ordinary vitamins that can be taken without fear for their health. Actually it is not. Incorrect medication can lead to severe metabolic disorders, disruption of the heart. I recommend using the remedy only on prescription in accordance with the instructions.

Anastasia Mikhailovna, cardiologist:

“Panangin is a good tool to restore the deficiency of potassium and magnesium ions in the body. The drug acts quickly, so that the therapeutic effect occurs after a short period of time. In addition, Panangin is used to reduce the side effects of certain other drugs and prevent various heart complications. I always recommend the drug to my patients.

Patient reviews

“I have taken this remedy several times in courses of 3 weeks. The doctor prescribed me Panangin in the form of tablets. I took the remedy in combination with other medicines, so I can’t say that the improvement in my well-being is only his merit. At least, I didn’t notice any negative effects, the condition returned to normal.”

Anastasia, Surgut

“I suffer from arrhythmia since my youth. After the examination, it turned out that this condition arose against the background of an imbalance in metabolic processes. After a course of treatment with Panangin, I feel much better, palpitations and shortness of breath occur less often. The drug is relatively inexpensive, the quality also suits me. ”

“Drank medicine after a heart attack. The doctor said that it is necessary to nourish the heart and restore metabolic processes. Six months after the course, I was again prescribed this drug for prevention. I was satisfied with the treatment."

Panangin

The description is current as of 06/06/2014

• Latin name: Pangin
• ATX code: A12CC30
• Active ingredient: Potassium and magnesium aspartate
• Manufacturer: Gedeon Richter (Hungary)

Composition of Panangin

The composition of the tablets

Active substances: magnesium aspartate (140 mg) and potassium aspartate (158 mg).

Additional substances: silicon dioxide, corn and potato starch, talc, povidone, magnesium stearate. The shell consists of talc, macrogol 6000, titanium dioxide, methacrylic acid copolymer.

Concentrate for solution (Panangin IV)

Contains magnesium aspartate (40 mg) and potassium aspartate (45.2 mg), as well as water for injection.

Release form

Available in tablet form, and as a concentrate solution.

pharmachologic effect

What is the cure for? It is a source of potassium and magnesium. The drug helps to restore electrolyte balance, regulates metabolic, metabolic reactions and processes, and has a pronounced antiarrhythmic effect. Potassium takes an active part in synaptic transmission, in the conduction of a nerve impulse along the fibers, in the implementation of muscle contractions, and supports the normal functioning of the heart. With impaired potassium metabolism, the excitability of muscle tissue and nerves changes. Active ion transport maintains a high potassium gradient across the plasma membrane. Small doses of potassium contribute to the expansion of the coronary arteries, and in large doses, the trace element narrows their lumen. Potassium has a moderate diuretic effect, a negative bathmotropic and chronotropic effect. Magnesium is a cofactor of three hundred enzyme reactions. Magnesium is an indispensable element in the course of processes and reactions that provide energy intake as well as expenditure. Magnesium is included in the pentose phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, RNA synthesis; is a natural BMCC, prevents the release of free fatty acids, catecholamines during stress, promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on the intercellular synthesis of phosphates.

Mn: potassium and magnesium aspartate.

Pharmacological group: potassium and magnesium drug.

Pharmacodynamics and pharmacokinetics

Active substances play an important role in the formation of bonds between macromolecules, as well as intracellular structures and the mechanism of muscle contraction, myocardial metabolism.

According to the annotation, the drug is well absorbed. Excreted through the kidneys.

Indications for Panangin's use

Panangin tablets - what are they from?

Indications for the use of Panangin are as follows. The drug is prescribed for hypomagnesemia, hypokalemia, when taking laxatives and diuretics, glucocorticosteroids, with diarrhea, persistent vomiting, taking saluretics, with myocardial infarction, heart failure, digitalis intoxication, ventricular extrasystole, atrial extrasystole, supraventricular tachycardia, paroxysmal tachycardia.

Example of a recipe in Latin: Rp.: Dragee "Panangin" N. 20

Contraindications for Panangin

The drug is not used for intolerance to fructose, sorbitol, impaired amino acid metabolism, chronic pathology of the renal system, hemolysis, exicosis, dehydration, arterial hypotension, myasthenia gravis, atrioventricular blockade, hypermagnesemia, hyperkalemia, metabolic acidosis, Addison's disease. Panangin during pregnancy is used with caution.

Side effects

Side effects are the following manifestations: ulceration of the mucous wall of the digestive tract, epigastric pain, diarrhea, bleeding from the digestive system, drop in blood pressure, bradycardia, a paradoxical reaction in the form of an increase in the number of extrasystoles, dry mouth, nausea, flatulence, hyporeflexia, skin itching , dyspnea, thrombosis, phlebitis, paresthesia, dizziness, increased sweating, asthenia, myasthenia gravis. With rapid intravenous infusion, hypermagnesemia, hyperkalemia are noted.

Application instruction of Panangin (Way and dosage)

Tablets Panangin, instructions for use

How to drink medicine? The drug is taken orally three times a day, 2 tablets. Supportive and prophylactic therapy: three times a day, 1 tablet, course for 3-4 weeks. In some situations, a repeat course of therapy is required.

Instructions for use intravenously

Panangin's solution is administered intravenously by drip, slowly. The drug is administered at a rate of drops per minute 1-2 times a day, 300 ml each. Dosing of the drug Panangin during pregnancy is carried out according to the standard scheme for the use of the drug.

Children can take medicine from birth.

How to take Panangin for prevention?

If you ask yourself the question of the benefits and harms of Panangin, you should realize that this is a drug that has its own side effects, so you should not use it for prevention. Firstly, in this way you accustom the body to a high content of magnesium and potassium, and secondly, you can provoke an excess of these substances, which in turn can cause a lot of negative reactions.

Overdose

Manifested by muscle hypotonia, hyperkalemia, slowing of atrioventricular conduction, cardiac arrest, arrhythmia, paresthesia of the extremities, changes in the electrocardiogram. An emergency intravenous infusion of a solution of dextrose, sodium chloride is required. If necessary, peritoneal dialysis, hemodialysis is justified.

Interaction

Panagin is able to enhance the negative bathmotropic, dromotropic effects of antiarrhythmic drugs. The drug eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, ISS. NSAIDs, ACE inhibitors, heparin, potassium-sparing diuretics, cyclosporine, beta-blockers increase the risk of hyperkalemia. When using general anesthetics, the inhibitory effect of Panangin on the nervous system is enhanced. Succinyl chloride, decamethonium, atracuronium, suxamethonium increase neuromuscular blockade. The use of enveloping and astringent medicines reduces the absorption of potassium and magnesium in the digestive tract. In combination with insulin, dextrose as part of a polarizing mixture, the heart rhythm normalizes in case of an overdose of cardiac glycosides, with ectopic arrhythmias, myocardial infarction. Panangin improves the tolerability of cardiac glycosides and is pharmaceutically compatible with their solutions.

Terms of sale

Does not require a prescription.

Storage conditions

In a place inaccessible to children at a temperature of degrees Celsius.

Best before date

Panangin's analogs

Alcohol compatibility

The drug is poorly compatible with alcohol, if only because the drug is usually used for problems with the heart and vascular system, and alcohol in these cases should be excluded. However, that's not all. With the simultaneous use of these substances, vasospasm may occur.

Reviews about Panangin

Reviews about Panangin on the forums are mostly positive. Buyers mark the drug as really effective, the drug facilitates the work of the heart, removes convulsions, really helps. It is noted as good pills for the heart.

Reviews about Panangin during pregnancy are as follows: the drug is often prescribed by doctors and is quite effective, despite the fact that in the description of the drug it is recommended to use the remedy with caution during this period.

Panangin price

The price of Panangin in tablets is 130 rubles, the price in ampoules is 160 rubles.

How much do pills cost in St. Petersburg? You can buy them at a cost of 125 rubles.

The price of Panangin is in Ukraine 120 and 130 UAH per tablet and solution, respectively.

• Internet pharmacies in Russia Russia
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PaniApteka

BIOSPHERE

Education: Graduated from the Bashkir State Medical University with a degree in General Medicine. In 2011 she received a diploma and a certificate in Therapy. In 2012 she received 2 certificates and diplomas in "Functional Diagnostics" and "Cardiology". In 2013, she took courses on "Actual Issues of Otorhinolaryngology in Therapy". In 2014, she completed advanced training courses in the specialty "Clinical Echocardiography" and courses in the specialty "Medical Rehabilitation".

Work experience: From 2011 to 2014, she worked as a general practitioner and cardiologist at MBUZ Polyclinic No. 33 in Ufa. Since 2014, she has been working as a cardiologist and functional diagnostics doctor at Polyclinic No. 33 in Ufa.

a very good drug: diastolic pressure and heart rhythm returned to normal, legs did not bother me at night (although a neurologist diagnosed me with RLS). I just don’t know whether to continue drinking or take a break, I’ve been drinking for a month

Lera: I was convinced from my own experience: ingavirin works.

Diana: I agree with Nika. When stuffy, I also always use the aquamaster, excellent.

Yu.L.: Without prejudice, I assure you, Laennec helps me with menopausal syndrome .. makes it easier.

Vladimir: Thank you for a good article that inspires confidence in the self-correction of vision. Strabismus since birth.

All materials presented on the site are for reference and informational purposes only and cannot be considered a method of treatment prescribed by a doctor or sufficient advice.

🔻🔻Important points of taking Panangin for prophylactic purposes

In cardiovascular diseases, Panangin is an effective medicine. It is recommended to take it with the appointment of a doctor, observing individual dosages. In addition, the drug is approved for prophylactic use.

Taking Panangin for prevention

Panangin for prevention should be used with great caution. This drug is intended to rid the body of numerous cardiovascular pathologies, including manifestations of coronary insufficiency. And also the medicine is allowed to drink to people suffering from a lack of oxygen compounds in the muscles.

Panangin reduces the number of malfunctions in the body, associated with a violation of metabolic processes in the myocardium due to a deficiency of potassium ions. In addition, the drug helps to reduce the manifestation of negative reactions caused by taking diuretic drugs that remove chloride ions with sodium from the body.

The correct use of Panangin for prevention is based on the absence of the required level of magnesium and potassium ions in the body.

Often the described medicine is prescribed for prophylactic purposes to persons suffering from a deficiency of vitamin and mineral compounds. In this regard, these tablets are drunk 2 times a day, 2 pcs. The prophylactic course should last at least a calendar month.

The cardiologist may prescribe the remedy described for a course of two weeks to persons who

• have been on a diet for a long time;
• work a lot physically;
• have been ill with the flu;
• suffered a cold.

Such preventive treatment will help to compensate for the lack of potassium and magnesium ions in people with cardiovascular diseases.

The dosage of the drug is prescribed privately, depending on the patient's health status. This is especially important to observe when a person's arrhythmia progresses.

Drug properties

Magnesium is characterized by an anti-ischemic effect on the myocardium, due to which these ions should always be present in the human body in the right quantities and contribute to increased blood flow through the coronary tract. From this, the pressure returns to normal.

The lack of potassium ions causes the development of dangerous types of arrhythmia with the formation of a stroke and defective heart function. Based on this, it is clear that it is dangerous to increase the daily amount of potassium consumed.

With its deficiency, taking Panangin significantly reduces the risk of developing a pre-stroke state.

The described medication strengthens the heart muscle, as well as

• makes the vascular walls elastic;
• promotes the conduction of the heart impulse;
• normalizes metabolic processes;
• prevents the manifestation of atherosclerosis;
• restores healthy functioning of the myocardium;
• protects the body from hypertension;
• reduces the possibility of premature wear and aging of the "muscle pump";
• relieves arrhythmias.

The active compounds of Panangin tend to slow down the growth of atherosclerotic plaques in the body, on the basis of which the level of blood viscosity decreases. Against this background, the likelihood of the formation of vascular thrombi decreases.

Why is Panangin prescribed?

In order for the heart to work correctly, Panangin tablets are often needed. They are indispensable for diagnosis.

• supraventricular tachycardia;
• intoxication;
• paroxysmal tachycardia;
• prolonged vomiting;
• manifestations of diarrhea;
• heart failure;
• hypomagnesemia;
• heart attack;
• spasms covering the calf apparatus;
• hypokalemia.

Panangin helps to restore a normal pulse, and tachycardia from its action practically disappears. Bradycardia (decrease in cardiac activity) is also successfully dived using the described remedy.

Instructions for use

Any heart disease must be treated correctly, observing the prescribed dosages of the drug used. Taking Panangin helps to reduce the manifestations of a heart attack in the case of its daily use in an amount of 3 pcs.

Tablets are allowed to be taken at the same time intervals, which means: morning, lunch and evening. Reduced levels of potassium and magnesium can be replenished by using the drug after a meal.

In some cases, the drug is prescribed to patients intravenously. This treatment option is characterized by better absorption of the drug with a high benefit value. Injections are prescribed exclusively by doctors, bypassing self-medication attempts.

Doctors include the medicinal content of Panangin in numerous combined therapies. In this case, the drug is diluted in glucose and delivered to the body through droppers. The dosage and frequency of such procedures is determined by the doctor for each patient individually.

Contraindications for admission

In rare cases, Panangin leads to side effects. The reason for this is an excessively long course of taking the medication with a predominance of high doses.

Among the contraindications should be noted

• failures in metabolic processes in amino acids;
• renal insufficiency;
• hypermagnesemia;
• intolerance to the components of the drug;
• hyperkalemia.

It is not advisable to drink the described tablets for persons in whose body diseases of the gastrointestinal nature are progressing. The reason for this is the interaction of the active compounds of the drug with the gastric mucosa, which can lead to irritation and pain in the abdominal area.

Side effects

Although side effects are rare, they do occur. Pregnant women should be wary of them, in the treatment of which this medication can be used.

When a woman is carrying a baby and suffering from shortness of breath and numerous heart diseases, she should not take this medicine. Pregnancy involves the use of the described medication only at the stage of the second or third trimester.

When breastfeeding, taking Panangin is harmful. In such situations, it is recommended to resort to the use of drug analogues that are less harmful to health.

The average daily dose of the drug for pregnant women is also reduced from 3 times a day, 2 tablets, to 2 times a day, 1/4 part.

Side effects are expressed in the manifestation of failures in the following systems

• cardiovascular:
• respiratory;
• digestive;
• nervous (peripheral and central).

Typically, people have a fever, nausea with bouts of vomiting, hyporeflexia, redness of the skin and convulsions.

Often, against the background of these manifestations, diarrhea begins.

In the event of the described side effects, it is necessary to visit a doctor regarding further medication.

In case of overdose

With an overdose of Panangin, the patient may develop hypermagnesemia or hyperkalemia. At the same time, people complain of a feeling of rapid fatigue and confusion. There may be a drop in blood pressure, and in severe cases, a coma.

If the described symptoms are detected, the medication should be stopped, and the patient should undergo therapy, which consists in introducing calcium chloride into the body in the form of a solution.