Solpadeine tablets - official instructions for use. Solpadeine active, soluble tablets

Instructions for medical use medicinal product

Solpadein Active

Tradename

Solpadein Active

International non-proprietary name

Dosage form

Soluble tablets

Compound

One tablet contains

activessubstancesa: paracetamol (powdered) 500 mg, caffeine anhydrous 65 mg

Excipients: sorbitol, sodium saccharin, sodium bicarbonate (especially thin bicarbonate), povidone K25, sodium lauryl sulfate, dimethicone, anhydrous citric acid, anhydrous sodium carbonate, purified water.

Description

Tablets white color, round shape, with a flat surface and bevelled edges, with a notch on one side.

Pharmacological group

Other analgesics-antipyretics. Anilides. Paracetamol in combination with other drugs (excluding psycholeptics)

ATX code N02BE51

Pharmacological properties

Pharmacokinetics

Paracetamol- quickly and almost completely absorbed (96%) from gastrointestinal tract. Paracetamol crosses the placental barrier and is excreted with breast milk in small quantities. Studies have established that paracetamol does not have a genotoxic and teratogenic effect. The maximum concentration in the blood is about 6 μg / ml, the time to reach the maximum concentration is 10-60 minutes. Plasma protein binding at therapeutic concentrations is minimal. Paracetamol is metabolized in the liver, most of it enters into conjugation reactions with glucuronic acid and sulfates to form inactive metabolites and is excreted in the urine in the form of sulfate and glucuronic conjugates. The elimination half-life (including in the elderly) averages 2.3 hours.

Caffeine- rapidly absorbed oral intake, the maximum plasma concentration is reached within one hour, the half-life is about 4.9 hours. 65-80% of ingested caffeine is excreted in the urine as 1-methyluric acid and 1-methylxanthine.

Pharmacodynamics

Paracetamol- analgesic-antipyretic. Provides pain relief and antipyretic effect by suppressing the synthesis of prostaglandins in the hypothalamus. In this regard, the use of paracetamol is especially advisable in patients for whom suppression of prostaglandin synthesis in peripheral tissues is undesirable, for example, in the presence of a history of gastrointestinal bleeding or in elderly patients.

Caffeine belongs to the group of alkaloids (methylxanthines). It has a psychostimulating and analeptic effect. In combination with analgesics, in particular paracetamol, it enhances its analgesic effect.

The drug has no effect on water-salt exchange, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Indications for use

painful mild syndrome and moderate: headache, migraine, toothache, pain after tooth extraction or other dental interventions, osteoarthritis pain, muscle and joint pain, sore throat, painful menstruation.

Fever Syndrome: fever and pain at colds and flu, as well as after vaccination.

Dosage and administration

Solpadeine Active tablets soluble before ingestion should be dissolved in at least half a glass of water.

Adults (including the elderly) and children over 12 years of age: Take 1-2 tablets by mouth every 4-6 hours as needed. Do not take more often than after 4 hours. Maximum single dose- 2 tablets. Do not take more than 8 tablets in 24 hours.

Do not exceed the indicated dose.

Side effects

Very rarely (<1/10,000)

Thrombocytopenia

Anaphylactic reactions

Hypersensitivity skin reactions including skin rash, angioedema, Stevens-Johnson syndrome

Bronchospasm in patients with hypersensitivity to acetylsalicylic acid and other NSAIDs

Liver dysfunction

Frequency unknown

Nervousness

Dizziness

Simultaneous use of the drug with caffeinated products (for example, coffee, tea, caffeinated drinks) can lead to sleep disturbance, anxiety, irritability, headache, gastrointestinal disorders and heart palpitations.

You should stop taking the drug and immediately consult a doctor if the above reactions occur, as well as the appearance of peeling, mouth ulcers, difficulty breathing, bruising, bleeding, or any other undesirable reaction to the drug.

Contraindications

Hypersensitivity to paracetamol or any other

drug ingredient

Severe liver or kidney dysfunction

Arterial hypertension

Glaucoma

Sleep disturbance

Children's age up to 12 years

Pregnancy

Drug Interactions

Paracetamol, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Irregular use of the drug does not have this effect.

special instructions

Before taking the drug, you should consult with your doctor:

Patients taking warfarin or other drugs to reduce blood clotting;

Patients with chronic liver or kidney disease;

If the headache becomes constant.

Patients on a low-salt or no-salt diet should be aware that each tablet contains 427 mg of sodium.

Patients with hereditary fructose intolerance should not take the drug due to the fact that each tablet contains 50 mg of sorbitol.

The use of paracetamol in conditions that reduce glutathione levels (eg, sepsis) increases the risk of metabolic acidosis.

When a combination of the following symptoms occurs:

Deep, rapid, labored breathing

Feeling unwell (nausea, vomiting)

Loss of appetite

you should consult a doctor.

Pregnancy and lactation

The drug is not recommended for use during pregnancy due to the possible risk of spontaneous abortion when using caffeine. Avoid taking the drug during breastfeeding, as caffeine is excreted in breast milk and may cause arousal in the child.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

There are no restrictions on driving a car and working with mechanisms.

Overdose

Paracetamol

Symptoms: nausea, vomiting, stomach pain, sweating, pallor of the skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of "liver" enzymes). In severe cases, liver failure, encephalopathy and coma develop.

Treatment: stop taking the drug and consult a doctor immediately. Recommended gastric lavage and intake of enterosorbents (activated carbon, polyphepan). Perhaps the use of N-acetylcysteine ​​or methionine.

Caffeine

Symptoms: pain in the epigastric region, nausea, increased urination, tachycardia or arrhythmia, symptoms of CNS stimulation (insomnia, excitement, anxiety, irritability, nervous tremors, tremors and convulsions).

Treatment: Symptomatic therapy. There is no specific antidote. The use of β-adrenergic antagonists may reduce the cardiotoxic effect.

sodium bicarbonate

Symptoms: high doses of sodium bicarbonate can cause gastrointestinal symptoms such as belching and nausea, as well as hypernatremia.

Treatment: It is necessary to control the level of electrolytes in the blood and carry out symptomatic therapy.

In case of accidental overdose, medical attention should be sought immediately, even if you feel well.

Release form and packaging

2 tablets per laminated strip (kraft bleached paper/polyethylene/aluminum foil/polyethylene or glass-coated paper/polyethylene/aluminum foil/surlin). 6 strips of 2 tablets together with instructions in the state and Russian languages ​​in a cardboard box.

Storage conditions

Store at a temperature not exceeding +25ºC.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date stated on the packaging.

Terms of dispensing from pharmacies

Without recipe

Manufacturer

Famar S.A., Greece

AT holder of the registration certificate

GlaxoSmithKline Consumer Helsker, UK

Address of the organization that accepts claims from consumers on the quality of products (goods) on the territory of the Republic of Kazakhstan:

Solpadin is an effective antipyretic and analgesic, the drug is an antipyretic of a combined composition, the ingredients of which are, and.

In this article, we will look at why doctors prescribe, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Solpadein can be read in the comments.

It produces two types of tablets: white capsule-shaped tablets labeled “Solpadeine”, soluble white tablets with a score. The first form is available in blisters of 5, 6, 8 and 12 pieces, the second - in strips of 2 pieces.

  • The composition of Solpadeine includes a complex of several active substances: 30 mg of caffeine, 500 mg of paracetamol, 8 mg of codeine phosphate hemihydrate, as well as various excipients.

Clinico-pharmacological group: combined analgesic-antipyretic.

Indications for use

Taking Solpadeine tablets is indicated to reduce the severity of the manifestations of the inflammatory reaction, as well as the intensity of pain in certain pathological conditions of the body, which include:

  • Cold;
  • Headache;
  • Periodic;
  • (inflammation of the throat);
  • Fever (a sharp increase in body temperature);
  • (pain spreading along the nerve);
  • Rheumatic diseases.
  • Also, the drug is used to symptomatically reduce the manifestations of colds, severity, as well as body temperature.

    pharmachologic effect

    The medicinal properties of this combined preparation are due to the action of the active substances that make up Solpadein.

    • Caffeine demonstrates a general tonic effect (reduces drowsiness, relieves fatigue, increases efficiency, speeds up the pulse, increases blood pressure in arterial hypotension), stimulates the analgesic effect of Solpadein.
    • The analgesic Paracetamol has an analgesic and antipyretic effect, stops COX1 and COX2 mainly in the central nervous system, affecting the centers of thermoregulation and pain.
    • Codeine has an analgesic effect and also improves pain tolerance.

    Instructions for use

    According to the instructions for use, Solpadeine is taken orally after meals. Tablets and capsules are swallowed whole with water; soluble tablets are pre-dissolved in 1/2 cup of water.

    • Adults and children over 16 years of age are prescribed 1-2 tablets. 3-4 times / day at intervals of at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.
    • Children aged 12 to 16 years are prescribed 1 tab. 3-4 times / day at intervals of at least 4 hours. The maximum single dose is 1 tab., The maximum daily dose is 4 tab.

    The drug should not be taken for more than 5 days when prescribed as an anesthetic and for more than 3 days as an antipyretic. Changing the dose and the interval between doses is set by the doctor.

    Contraindications

    Among the contraindications to the use of this medication, conditions such as:

    • deficiency of glucose-6-phosphate dehydrogenase;
    • diseases of the circulatory system;
    • violation of the functioning of the liver and kidneys;
    • pregnancy and lactation;
    • elderly age;
    • children's age up to 12 years;
    • hypersensitivity to the ingredients present in the composition of this medication.

    Solpadeine should be taken with caution in alcoholism, elderly patients, as well as in patients with benign hyperbilirubinemia (including Gilbert and Dubin-Johnson syndromes), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, glaucoma, increased excitability, a tendency to convulsive seizures.

    Side effects

    In most cases, if Solpadeine is used in accordance with the recommended regimen, therapy is well tolerated.

    Paracetamol, which is part of Solpadeine, can cause side effects such as hemolytic,. With prolonged use of high doses, the threat of developing disorders of the kidneys and liver is exacerbated.

    Codeine provokes such side effects:

    • digestive system: nausea, vomiting, gastralgia;
    • cardiovascular system: a feeling of increased heartbeat,;
    • central nervous system: drowsiness, dizziness, sleep disturbances.

    Caffeine can cause these side effects.

    Solpadeine is a well-known drug with combined formulations, which includes paracetamol, caffeine, and sometimes codeine. It effectively copes with pain and fever, has a general tonic effect on the body. Recommended for use with various kinds of pain, colds, etc.

    Indications for use

    Solpadein tablets are used in the treatment of:

    • Headaches
    • Migraine
    • neuralgia
    • Colds
    • Pharyngitis
    • Fever
    • rheumatic pathologies.

    You can take medicine for toothache, it also helps with a decrease in body temperature.

    The composition of the drug

    Active Ingredients: Paracetamol, Caffeine

    Minor: starch, povidone, potassium sorbate, talc, stearic acid, triacetin, etc.

    Medicinal properties

    The effectiveness of the drug is ensured by its main components. Paracetamol has antipyretic and antispasmodic activity due to selective inhibition of prostaglandin synthesis in the central nervous system. Caffeine increases the analgesic effect of paracetamol. The drug is rapidly absorbed and enters the tissues and cells. Metabolized in the liver, excreted mainly by the kidneys within 24 hours.

    Release forms

    The price is from 97 to 200 rubles.

    Film-coated tablets, 8 or 12 pieces in a blister, in a carton box 1 blister.

    Effervescent tablets, white in a laminated strip, 2 pcs, 6 strips per pack.

    Mode of application

    It is prescribed 1-2 tablets, 3-4 times a day. After the dose taken, at least 4 hours should pass. The duration of the course is no more than 5 days, further treatment is continued only as directed by the doctor.

    During pregnancy and breastfeeding

    Solpadein Fast instructions for pregnant women to take the medicine prohibits. During lactation, you can drink pills, but only after consulting a doctor and under his control.

    Contraindications

    Solpadin is not allowed in case of diagnosing such pathologies:

    • Serious ailments of the kidneys and liver
    • Bronchial asthma
    • High intracranial pressure
    • Oppressed breathing
    • Head injury
    • Signs of glaucoma
    • Epilepsy.

    Contraindications to the use of the drug is also intolerance to any components of the drug, after the operating period on the biliary tract. It is forbidden to drink Solpadein effervescent tablets during pregnancy. The medication is not prescribed in tablet form for babies under 7 years old, but in the form of capsules for children under 12 years old.

    Precautionary measures

    The use of the drug Solpadein should be carried out only as directed by a specialist, self-administration is not allowed.

    Caution should be combined with MAO inhibitors.

    Also, special care must be taken by patients with viral hepatitis and benign tumors.

    Do not take the drug together with alcoholic beverages.

    During therapy with Solpadeine, the use of strong coffee and tea in large doses may affect irritability and increased tension.

    The drug often causes drowsiness, therefore, when taking it, it is better to refuse to drive vehicles and work where increased concentration is required.

    Cross-drug interactions

    Do not combine with medicines, which include paracetamol.

    Warfarin and some other coumarins increase the risk of bleeding.

    Phenytoin, Rifampicin, tricyclic antidepressants in parallel with Solpadein can cause severe intoxication.

    The absorption of ergotamine increases the caffeine contained in the specified drug.

    Domperidone and metoclopramide reduce the absorption of paracetamol.

    Joint use significantly reduces the effectiveness of uricosuric agents.

    Side effects

    Among the possible negative symptoms of Solpaden soluble tablets, the following manifestations are distinguished:

    • Allergies (rashes, swelling, hives)
    • Nausea, stool problems, manifested by constipation
    • excitability of the nervous system
    • Drowsiness or lack of sleep.

    With prolonged use, there is a risk of developing a hepatotoxic effect.

    Overdose

    If the norms of Solpadein are exceeded, negative manifestations are diagnosed for each component of the drug:

    • Paracetamol: nausea, vomiting, abnormal liver function, pallor of the skin, anorexia, abdominal pain.
    • Caffeine: increased nervousness, irritability, sleep disturbance, urinary problems, flushing, rapid heart rate, gastrointestinal dysfunction.
    • Codeine: respiratory failure, arterial hypotension, signs of miosis.

    In this situation, symptomatic therapy prescribed by a doctor is indicated.

    Terms and conditions of storage

    According to the instructions for use, Solpadein fast is supposed to be stored at a temperature of 23-25 ​​degrees Celsius, keeping away from children.

    The period of suitability is not more than 5 years.

    Analogues

    Nurofen

    Reckitt Benckiser, UK

    Price from 95 to 420 rubles

    Nurofen is one of the non-steroidal anti-inflammatory drugs based on ibuprofen. It lowers the temperature well, quickly eliminates pain. Reception is allowed for headaches, toothaches and muscle pains, it can also be taken for colds, flu, etc. It is available in the form of capsules, effervescent tablets, syrup, ointment and cream are absent.

    Pros:

    • Fast action
    • Convenient forms of release.

    Minuses:

    • Many contraindications
    • There are side effects.

    Prohodol

    ICN Leksredstva, Russia

    Price from 67 to 85 rubles

    Prochodol is an analgesic medication that helps to quickly and effectively cope with pain. It is prescribed for febrile syndrome, for pain in the joints, muscles, head. It has a wide variety of dosage forms: capsules, powder, injection, suppositories, suspension.

    Pros:

    • Effective remedy
    • Many forms of release.

    Minuses:

    • Cannot be taken for a long period
    • There are many contraindications.

    Pain syndrome (headache, rheumatic pain, toothache, migraine, menalgia, neuralgia, lumbago, traumatic pain, sprain pain), sinusitis, fever, colds and influenza (symptomatic treatment).

    Release form of the drug Solpadein

    tablets; blister 12 box (box) 1.
    tablets; blister 6 box (box) 2.
    tablets; blister 8 box (box) 1.
    tablets; blister 5 box (box) 2.
    tablets; blister 5 box (box) 1.
    tablets; blister 5 plastic cover 1.
    tablets; blister 10 plastic cover 1.
    tablets; blister 6 plastic cover 1.

    Pharmacodynamics of the drug Solpadein

    Paracetamol exhibits antipyretic and analgesic effects, selectively inhibiting the synthesis of PG in the central nervous system. Codeine, by stimulating the opiate receptors of the brain, changes the nature of pain perception, suppresses coughing. Caffeine enhances the analgesic properties of paracetamol and codeine due to its stimulating effect on the central nervous system, can eliminate depression associated with pain and, in addition, by increasing the permeability of histohematogenous barriers, increases the concentration of other components of Solpadeine in the brain.

    Pharmacokinetics of Solpadeine

    Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract; plasma concentration reaches a peak value in 15–60 minutes. T1 / 2 in plasma - 1-4 hours. Relatively evenly distributed in the body, 20-30% binds to plasma proteins. It is excreted in the urine as metabolites (when taking a therapeutic dose, 100% is excreted in the urine in 24 hours). Codeine phosphate is well absorbed in the gastrointestinal tract and biotransformed in the liver to metabolites (morphine, norcodeine, etc.). It is excreted from the body with urine, mainly in the form of compounds with glucuronic acid. T1 / 2 in plasma - 3-4 hours. Caffeine is rapidly absorbed, Cmax is reached after 20-60 minutes, T1 / 2 - about 4 hours. For 48 hours, about 45% is excreted in the urine in the form of 1-methylcarbamide acid and 1-methylxanthine .

    Solpadeine use during pregnancy

    Contraindicated in pregnancy. During breastfeeding, it is permissible, but after consulting a doctor.

    Contraindications to the use of the drug Solpadein

    Hypersensitivity, acute attacks of bronchial asthma, respiratory failure, head injuries, increased intracranial pressure, conditions after operations on the biliary tract.

    Side effects of the drug Solpadein

    Nausea, vomiting, dizziness, insomnia, nervous agitation, constipation, allergic reactions (skin rashes).

    Dosage and administration of Solpadeine

    Inside (up to 4 times a day with a minimum interval between doses of 4 hours) for adults, 2 tablets. (caps.) up to 4 times a day (maximum daily dose - 8 tablets. (caps.)), children from 7 to 12 years old - 1/2-1 table. (the maximum daily dose is 4 tablets). Soluble tablets are pre-dissolved in a glass of water.

    Overdose with Solpadeine

    Complications of overdose are most likely in patients with non-cirrhotic liver disease. Symptoms - pallor, nausea, vomiting, anorexia, abdominal pain, signs of circulatory and respiratory depression, tremor, nervousness, irritability.

    Treatment - with an overdose of paracetamol - taking meglonin orally or in / in the introduction of N-acetylcysteine; with an overdose of caffeine - gastric lavage, in severe cases - artificial ventilation of the lungs, the use of oxygen and naloxone.

    Precautions while using Solpadeine

    Do not use together with other paracetamol-containing products, give capsules, tablets to children under 12 years old, and soluble tablets up to 7 years old. It is not recommended to violate the dosing regimen - no more than 4 doses in 24 hours. Take with caution in acute kidney disease and liver disease in combination with MAO inhibitors, against the background of alcohol. Excessive consumption of coffee and tea can cause tension and irritability.

    Storage conditions of the drug Solpadein

    At a temperature not higher than 25 °C.

    Solpadeine expiration date

    Belonging of the drug Solpadeine to the ATX-classification:

    N Nervous system

    N02 Analgesics

    N02B Analgesics and antipyretics

    Recently, advertising has often begun to promote more and more new medicines to the masses. These include "Solpadein". What this drug is from, what are the indications and contraindications for its use, we will tell in the article.

    About the drug

    The tool appeared in our pharmacies relatively recently. It is produced in three forms: tablets, capsules and effervescent soluble tablets. Produced by the well-known pharmaceutical company in Spain "SmithKline Beecham".

    This drug belongs to painkillers (analgesics). The difference between the remedy is as follows: "Solpadein" effervescent acts very quickly, which distinguishes it favorably from other means of a similar orientation.

    I am pleased with the wide spectrum of action of the drug. In his "jurisdiction" - the fight against headache, dental, postoperative and post-traumatic. He has relatively few side effects and contraindications. The biggest downside is the price of the product.

    Compound

    The effectiveness of the drug is due to its composition. However, Solpadein, whose application is quite simple and convenient, does not contain any rare or unusual components. Before us is a complex drug, consisting of several components. The main active ingredient is paracetamol, familiar to us from childhood, an analgesic and antipyretic. It has a slight anti-inflammatory effect.

    The second component of the drug "Solpadein" (from which it is, we will describe in more detail below) is caffeine. This substance is known for its stimulating effect on the nervous system. Positive effects include the effect on the production of adrenaline and dopamine (substances that can reduce pain), a favorable, mobilizing effect on the muscles.

    "Solpadein" also contains a small amount of codeine phosphate - an analgesic narcotic substance with a strong analgesic effect.

    All components together act on the central nervous system, eliminate spasm, minimize pain and discomfort after injuries and operations.

    Tablets "Solpadein". Instruction

    The drug should be taken only as directed or after consulting a doctor.

    The maximum daily dose for an adult is eight capsules. Use for more than three days must be discussed with a specialist.

    The drug, depending on the form of release, is taken in capsules or dissolved in warm water, juice. With intense pain, it is recommended to drink one to two capsules every four hours.

    "Solpadein" from what helps?

    Let's move on to the main question. From what, in what cases is it recommended to use Solpadein to get rid of pain?

    • Headache of various etiologies (including migraine).
    • Neuralgia, lumbago and sciatica.
    • Back pain of any origin.
    • Toothache (during inflammatory processes, during treatment, after tooth extraction and other manipulations in the oral cavity).
    • Severe pain in the joints and muscles (with arthritis and arthrosis, trauma, inflammation and in the postoperative period).
    • Periodic pain in women.

    The tool is effective and fast. But do not forget that its purpose of use is not treatment, but getting rid of pain. If they are so intense that a person needs a pain reliever, a doctor's consultation is necessary. "Solpadein" (effervescent tablets, capsules or regular tablets - choose the form together with a specialist) will save you from discomfort, but not from the disease itself.

    Indication for use

    Most of the cases where the drug will help, we have listed above. Sometimes the remedy is mistakenly used for fever and temperature. This is not entirely advisable, since in this case the usual Paracetamol, which, most likely, is in every first aid kit, would do just fine. "Solpadein" from what helps it was considered.

    Contraindications. Who should not "Solpadein"

    The tool, like any other, has a number of contraindications. Among them are the following:

    • Solpadein is not shown to you if there is a history of an allergic reaction to opium analgesics.
    • If you have previously had a head injury and / or increased intracranial pressure.
    • With severe disorders of the kidneys and liver.
    • Thrombosis and thrombophlebitis.
    • Bronchial asthma or a tendency to bronchospasm.
    • Diseases of the cardiovascular system, including heart failure and coronary heart disease.
    • Diabetes mellitus and hyperthyroidism.
    • Sleep disturbances, depression or nervous tension.
    • Epilepsy or a tendency to this disease.

    The drug is also contraindicated in pregnancy and lactation and in elderly patients.

    It is unsafe to use "Solpadein" (effervescent tablets, the use of which, like capsules, can be harmful to health, should not be taken without a doctor's recommendation) with a single use of alcohol or alcoholism. Any amount of alcohol you drink is equally dangerous.

    Special instructions. What to pay attention to

    As we remember from the instructions above, Solpadein contains high doses of caffeine. This means that the drug will be contraindicated for ardent "coffee lovers" who cannot imagine their life without several cups of strong coffee a day. As you understand, the amount of caffeine in the body of a person who consumes a lot of this invigorating drink is already quite high. Taking "Solpadein" in this case can cause a serious overdose of caffeine, the mildest consequences of which will be insomnia, a feeling of unreasonable anxiety and a depressive state.

    One more note: do not forget that a significant amount of caffeine is found not only in coffee, but also in tea, including green varieties of this drink.

    It is unacceptable when taking "Solpadein" the use of any, even weak alcohol. It is also worth remembering that the drug contains a high dose of paracetamol, so combining these drugs is not recommended.

    Side effects

    As with the use of any medicine, the use of the drug may cause side effects.

    From the side of the cardiovascular system, these are tachycardia and arrhythmia; the gastrointestinal tract may respond to the reception of "Solpadein" with nausea and the urge to vomit, discomfort in the epigastric region, with prolonged use - constipation.

    There is a possibility of allergic reactions from the skin, such as itching, rash, urticaria, etc. In very rare cases, it is fixed. It should also be borne in mind that with prolonged use of the drug, its toxic effect on the liver increases. The consequences may be an increase in liver enzymes, severe vomiting and sensations of pain and heaviness in the right side. Treatment in these cases involves stopping the medication and eliminating the symptoms.

    With the use of barbiturates (sedatives, the most famous of which are Valocordin, Nitrazepam) and Rifampicin, the effect on the liver increases significantly. It is worth being very careful when combining these drugs with the one we are considering.

    Solpadein and cough

    Another feature of the drug is that it can save you from a severe cough. Codeine has a strong effect on cough centers and is able to stop and stop severe bouts of residual cough after bronchitis or SARS. However, it is worth remembering that the drug is by no means a panacea in the treatment of cough! It only removes unpleasant symptoms in case of urgent need (for example, during a scheduled lecture or meeting). Treatment should be prescribed to you by a doctor, based on the anamnesis and the tests obtained.

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