"Indapamide": analogues. "Indapamide": reviews of doctors
What is the drug "Indapamide"? Analogues of this remedy, its instructions, side effects and indications for use will be presented below. In addition, from this article you will learn about whether this medication has contraindications, what to do in case of an overdose, how it should be taken, whether it can be combined with other drugs, and what experts think about it.
The composition of the medicinal product and its form of release
In what form is this drug marketed? In a pharmacy, it can only be found in the form of biconvex tablets, coated with a white film shell.
What active ingredient does the drug "Indapamide" include? Analogues of this remedy (most of them) and the drug itself contain such an active ingredient as indapamide. As for excipients, the tablets include the following elements: lactose monohydrate, crospovidone, povidone K-30, magnesium stearate, talc and
Pharmacological action of the drug
What properties does the drug "Indapamide" have, the price of which is presented at the very end of the article? This medicine belongs to the antihypertensive drug. In other words, it is a diuretic and a vasodilator.
In terms of its pharmacological properties, the drug is very close to thiazide diuretics and is taken in violation of the reabsorption of sodium salts, which are located in the cortical segment of the loop of Henle. It is able to increase the excretion of chlorine, magnesium, sodium and potassium ions along with urine.
Why is the drug "Indapamide" prescribed? Analogues of this agent and the mentioned medication itself have the ability to block “slowed down” calcium channels in a selective manner, increase the elasticity of the walls of blood vessels and lower the total vascular resistance (peripheral).
Taking this drug reduces the hypertrophy of the heart, or rather its left ventricle. It does not affect the volume of lipids in the blood, as well as carbohydrate metabolism, including in people with a disease such as diabetes. 
The mentioned drug reduces the sensitivity of the vascular wall to angiotensin II and norepinephrine, reduces the production of stable and free oxygen radicals, and stimulates the synthesis of prostaglandin E2.
After the use of the drug, the hypotensive effect develops by the end of the 1st week of therapy. At the same time, it persists for 25 hours (after taking one tablet)
Pharmacokinetics of the drug
Where is the drug "Indapamide" absorbed? Instructions, reviews of experts say that after taking the drug inside, it is almost completely and instantly absorbed from the gastrointestinal tract. According to pharmacists, its bioavailability is 93%. Simultaneous intake of food slightly slows down the rate of absorption, although it does not affect the volume of the absorbed active element.
The maximum concentration of the active ingredient in the blood plasma is reached approximately 2 hours after taking one tablet. The half-life of the drug is 14-25 hours. Communication with blood proteins - about 79%.
This drug passes well through the histohematogenous barrier (including placental). It also passes into breast milk.
Metabolism of the drug is carried out in the liver. It is excreted by the kidneys (as metabolites) in the amount of 60-80% and 20% - through the intestines.
Indications for the use of the drug
In what cases is the drug "Indapamide" prescribed to patients? Indications for the use of this remedy include only one pathological condition of the patient. This In addition, the medication can be prescribed for sodium and water retention in the body. As a rule, this condition is very often observed in chronic heart failure. 
Contraindications to the use of the drug
Now you know what the drug "Indapamide" is intended for (indications for the use of this drug were presented a little higher). However, it should be noted that this medication has contraindications. These include the following factors:
- lactose intolerance by the patient;
- period of pregnancy;
- galactosemia;
- hypokalemia;
- galactose or glucose malabsorption syndrome;
- lactation period;
- the simultaneous use of medications that can prolong the QT interval;
- severe renal failure (or stage of anuria);
- the age of a person under 18 years of age (the safety and efficacy of the drug in the treatment of children have not been established);
- severe hepatic, including with encephalopathy, insufficiency;
- hypersensitivity to the drug and other sulfonamide derivatives.
Cautious use of medication
Many people are interested in: do I need a prescription to purchase Indapamide? In fact, before using any drug, it is recommended to consult a doctor - only a specialist, after examination and based on the results of the tests, will be able to build a competent treatment regimen. As for our case, we note that the remedy in question is prescribed with extreme caution to people with diabetes mellitus, gout, as well as to those patients who are allergic to sulfonamide derivatives.
Among other things, the medicine should be taken with caution in violations of the liver, kidneys and water-electrolyte imbalance.
During therapy, the doctor must constantly monitor the level of electrolytes in the patient's blood (potassium, sodium, calcium). 
The drug "Indapamide": instructions for use, expert reviews
According to the attached instructions, this medication must be taken orally, regardless of food intake. The tablet should be washed down with a sufficient amount of clean water.
How to take "Indapamide"? According to experts, this medication is better absorbed from the gastrointestinal tract only early in the morning. Therefore, it is recommended to take it exclusively at this time of the day.
The dosage of the drug should be 2.5 mg (i.e. 1 tablet) per day. If after 4-8 weeks of therapy the desired effect has not been achieved, then the volume of the medication should not be increased (although doctors often do just that). This fact is due to the fact that with a large dosage, the risk of side effects increases. Instead, drug therapy should include another antihypertensive agent that is not a diuretic.
How to take "Indapamide" in this case? With the simultaneous appointment of two drugs, the dose of the drug we are considering remains the same, that is, 2.5 mg per day (early in the morning).
Cases of overdose: symptoms, treatment
What happens if you take a large amount of the drug "Indapamide"? Reviews of doctors say that in such cases the patient experiences nausea, weakness and vomiting. In addition, the patient's water-electrolyte balance and the functioning of the digestive tract are disturbed. In some cases, the patient has a strong decrease in blood pressure and oppressed breathing. In patients with cirrhosis of the liver,
How to treat? In case of an overdose, the patient should wash the stomach, correct the water and electrolyte balance, and apply symptomatic therapy. 
Side effects after taking the medication
Can negative reactions occur after taking the drug "Indapamide"? This drug has side effects. Let's list them right now.
- Digestive system: gastralgia, nausea, vomiting, anorexia, constipation, dry mouth, pancreatitis, diarrhea,
- Respiratory system: sinusitis, cough, rhinitis and pharyngitis.
- Nervous system: insomnia, asthenia, muscle spasms, nervousness, general weakness, anxiety, headaches, fatigue, vertigo, dizziness, depression, drowsiness, irritability, malaise and tension.
- Urinary system: nocturia, frequent infections and polyuria.
- Heart and blood vessels: arrhythmia, orthostatic hypotension, palpitations and ECG changes (i.e. hypokalemia).
- Allergies: urticaria, rash, hemorrhagic vasculitis and itching.
- Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, bone marrow aplasia and agranulocytosis.
- Laboratory indicators: glucosuria, hyperuricemia, increased plasma urea nitrogen, hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia and hypochloremia.
- Others: exacerbation of systemic lupus erythematosus.
Interaction with other medicines
The drug "Indapamide", whose action is aimed at lowering pressure, is not recommended to be taken together with cardiac glycosides, as the likelihood of digitalis intoxication increases. If you use this remedy with calcium preparations and metformin, then the patient may develop hypercalcemia and worsen lactic acidosis. 
Simultaneous administration of the drug with corticosteroids, NSAIDs, sympathomimetics and tetracosactide lowers the hypotensive effect of the former. As for the Baclofen remedy, on the contrary, it intensifies with it.
The combination of the drug with potassium-sparing diuretics is effective in a small number of patients. However, the possibility of developing hyper- or hypokalemia is not excluded, especially in patients with renal insufficiency and diabetes mellitus.
ACE inhibitors can increase the risk of arterial hypotension and acute renal failure.
Kidney function may be impaired with the simultaneous use of iodine-containing drugs in high doses.
Antipsychotics and imipramine antidepressants enhance the hypotensive effect and increase the risk of orthostatic hypotension.
Special instructions for the use of the drug "Indapamide"
In what cases should the patient's blood picture be monitored after the appointment of the drug "Indapamide"? The doctors' comments say that this medication can change the amount of creatinine and potassium ions in those patients who take laxatives, cardiac glycosides, and also in people over 60 years of age.
When using this tool, specialists are advised to systematically monitor the concentration of sodium, potassium and magnesium ions in the blood plasma, as patients may develop electrolyte disturbances. It is also necessary to monitor the pH, the concentration of uric acid, glucose and residual nitrogen. 
Patients with cirrhosis of the liver (with severe edema or ascites), as well as with heart failure and coronary heart disease, should be subjected to special control.
The high-risk group includes patients with an increased QT interval on the ECG (may be congenital or develop against the background of any pathology).
The first measurement of the concentration of potassium ions in the patient's blood is recommended in the first week of treatment.
Patients taking this medication should compensate for water loss by drinking plenty of fluids per day. Moreover, at the very beginning of therapy, they need to control the functioning of the kidneys.
It is impossible not to say that the drug "Indapamide", analogues of which will be presented below, can give a positive result during doping control.
Patients with hyponatremia and arterial hypertension should stop taking diuretics 3 days before starting the use of angiotensin-converting enzyme inhibitors. Treatment can be resumed a little later.
When prescribing the drug "Indapamide", specialists should take into account that sulfonamide derivatives can easily cause an exacerbation of a disease such as systemic lupus erythematosus.
To date, the safety and efficacy of the drug in the treatment of young children and adolescents has not been established. 
In some cases, individual reactions are possible, which are associated with changes in blood pressure. As a rule, this happens at the very beginning of therapy, as well as when using another. As a result, the ability to drive a machine and work with other mechanisms may decrease, which require increased attention.
